NSUN6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of DNA endoreduplication (GO:0032875)8.89404216
2intra-S DNA damage checkpoint (GO:0031573)8.27445281
3telomere maintenance via telomerase (GO:0007004)7.24642883
4synapsis (GO:0007129)6.30728604
5RNA-dependent DNA replication (GO:0006278)6.27455200
6axon ensheathment in central nervous system (GO:0032291)6.12183557
7central nervous system myelination (GO:0022010)6.12183557
8presynaptic membrane organization (GO:0097090)6.07815130
9base-excision repair, AP site formation (GO:0006285)5.74595747
10presynaptic membrane assembly (GO:0097105)5.60164014
11mitotic G2 DNA damage checkpoint (GO:0007095)5.50705586
12negative regulation of DNA-dependent DNA replication (GO:2000104)5.39504035
13purine deoxyribonucleotide catabolic process (GO:0009155)5.32549055
14positive regulation of protein autophosphorylation (GO:0031954)5.30329700
15regulation of telomere maintenance via telomerase (GO:0032210)4.79466878
16non-recombinational repair (GO:0000726)4.78501456
17double-strand break repair via nonhomologous end joining (GO:0006303)4.78501456
18regulation of somitogenesis (GO:0014807)4.52848492
19mitotic G2/M transition checkpoint (GO:0044818)4.44115513
20DNA double-strand break processing (GO:0000729)4.37713704
21positive regulation of monocyte chemotaxis (GO:0090026)4.01676882
22meiotic cell cycle (GO:0051321)3.97626255
23cellular response to cadmium ion (GO:0071276)3.93884165
24mannosylation (GO:0097502)3.93110125
25deoxyribonucleotide catabolic process (GO:0009264)3.85813347
26mitochondrial respiratory chain complex I assembly (GO:0032981)3.80420046
27NADH dehydrogenase complex assembly (GO:0010257)3.80420046
28mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.80420046
29behavioral response to nicotine (GO:0035095)3.73727861
30response to folic acid (GO:0051593)3.68380413
31developmental pigmentation (GO:0048066)3.59825116
32left/right axis specification (GO:0070986)3.57065596
33replication fork processing (GO:0031297)3.56740753
34regulation of hexokinase activity (GO:1903299)3.55913221
35regulation of glucokinase activity (GO:0033131)3.55913221
36water-soluble vitamin biosynthetic process (GO:0042364)3.55525117
37antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.51202916
38autophagic vacuole fusion (GO:0000046)3.47543298
39deoxyribose phosphate catabolic process (GO:0046386)3.39865127
40sister chromatid cohesion (GO:0007062)3.39635960
41neuron cell-cell adhesion (GO:0007158)3.38678371
42mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.34180764
43superoxide anion generation (GO:0042554)3.30926575
44regulation of cilium movement (GO:0003352)3.30819973
45detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.28523013
46respiratory burst (GO:0045730)3.24526815
47DNA deamination (GO:0045006)3.15761363
48L-amino acid import (GO:0043092)3.15163265
49protein prenylation (GO:0018342)3.13647654
50prenylation (GO:0097354)3.13647654
51epithelial cilium movement (GO:0003351)3.13220045
52purine deoxyribonucleotide metabolic process (GO:0009151)3.12996515
53proteasome assembly (GO:0043248)3.11881623
54resolution of meiotic recombination intermediates (GO:0000712)3.09976424
55nonmotile primary cilium assembly (GO:0035058)3.09441583
56L-fucose metabolic process (GO:0042354)3.08984528
57L-fucose catabolic process (GO:0042355)3.08984528
58fucose catabolic process (GO:0019317)3.08984528
59DNA ligation (GO:0006266)3.08737665
60nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.08638724
61platelet formation (GO:0030220)3.07848493
62GPI anchor biosynthetic process (GO:0006506)3.07196992
63respiratory chain complex IV assembly (GO:0008535)3.05572786
64activated T cell proliferation (GO:0050798)3.05108137
65neural tube formation (GO:0001841)3.04971444
66GPI anchor metabolic process (GO:0006505)3.04528673
67negative regulation of acute inflammatory response (GO:0002674)3.04458859
68intraciliary transport (GO:0042073)3.03064776
69cellular ketone body metabolic process (GO:0046950)3.00837257
70defense response to protozoan (GO:0042832)3.00552423
71protein complex biogenesis (GO:0070271)3.00342790
72exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.00071704
73protein polyglutamylation (GO:0018095)2.97727099
74recombinational repair (GO:0000725)2.96732159
75NIK/NF-kappaB signaling (GO:0038061)2.96223970
76indolalkylamine metabolic process (GO:0006586)2.95857256
77double-strand break repair via homologous recombination (GO:0000724)2.95453584
78regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.94756520
79regulation of mitotic spindle checkpoint (GO:1903504)2.94756520
80somatic hypermutation of immunoglobulin genes (GO:0016446)2.94498921
81somatic diversification of immune receptors via somatic mutation (GO:0002566)2.94498921
82regulation of meiosis I (GO:0060631)2.93038944
83pyrimidine nucleobase catabolic process (GO:0006208)2.91435027
84cytochrome complex assembly (GO:0017004)2.89892916
85maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.88905663
86piRNA metabolic process (GO:0034587)2.88555947
87protein K6-linked ubiquitination (GO:0085020)2.87682047
88axoneme assembly (GO:0035082)2.86664372
89regulation of monocyte chemotaxis (GO:0090025)2.85647278
90S-adenosylmethionine metabolic process (GO:0046500)2.85277975
91reciprocal DNA recombination (GO:0035825)2.84915583
92reciprocal meiotic recombination (GO:0007131)2.84915583
93tryptophan catabolic process (GO:0006569)2.82900952
94indole-containing compound catabolic process (GO:0042436)2.82900952
95indolalkylamine catabolic process (GO:0046218)2.82900952
96pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.80645496
97response to pheromone (GO:0019236)2.79842402
98axonemal dynein complex assembly (GO:0070286)2.77594610
99centriole assembly (GO:0098534)2.76124152
100ATP synthesis coupled proton transport (GO:0015986)2.76065554
101energy coupled proton transport, down electrochemical gradient (GO:0015985)2.76065554
102response to muramyl dipeptide (GO:0032495)2.74496734
103establishment of protein localization to mitochondrial membrane (GO:0090151)2.73610646
104nucleobase catabolic process (GO:0046113)2.72949490
105positive regulation of oligodendrocyte differentiation (GO:0048714)2.72752601
106negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.71753421
107long-chain fatty acid biosynthetic process (GO:0042759)2.70994815
108protein localization to cilium (GO:0061512)2.70611021
109regulation of protein autophosphorylation (GO:0031952)2.70370568
110dendritic cell chemotaxis (GO:0002407)2.70013979
111DNA methylation involved in gamete generation (GO:0043046)2.69496683
112dopamine transport (GO:0015872)2.68459384
1132-deoxyribonucleotide metabolic process (GO:0009394)2.68455388
114histone H2B ubiquitination (GO:0033523)2.67891757
115membrane assembly (GO:0071709)2.66226847
116necroptotic process (GO:0070266)2.65942480
117negative regulation of DNA recombination (GO:0045910)2.65662469
118regulation of nuclear cell cycle DNA replication (GO:0033262)2.64731841
119positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.64643890
120mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.64643890
121fatty acid elongation (GO:0030497)2.64504081
122hydrogen peroxide biosynthetic process (GO:0050665)2.63565881
123cilium organization (GO:0044782)2.62682252
124spermatid nucleus differentiation (GO:0007289)2.62415004
125negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.62249411
126histamine secretion (GO:0001821)2.62241122
127protein-cofactor linkage (GO:0018065)2.61950928
128dendritic cell migration (GO:0036336)2.60726893
129detection of light stimulus involved in visual perception (GO:0050908)2.60229803
130detection of light stimulus involved in sensory perception (GO:0050962)2.60229803
131regulation of clathrin-mediated endocytosis (GO:2000369)2.60056283
132oxidative demethylation (GO:0070989)2.58867898
133ketone body metabolic process (GO:1902224)2.58589774
134positive regulation of cellular amide metabolic process (GO:0034250)2.58242464
135cilium assembly (GO:0042384)2.58039877
136protein K11-linked deubiquitination (GO:0035871)2.57560868
137intracellular pH reduction (GO:0051452)2.57445510
138negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.57210580
139negative regulation of translation, ncRNA-mediated (GO:0040033)2.57210580
140regulation of translation, ncRNA-mediated (GO:0045974)2.57210580
141postreplication repair (GO:0006301)2.57093278
142exogenous drug catabolic process (GO:0042738)2.56897452
143RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.56070878
144viral protein processing (GO:0019082)2.55720365
145peptidyl-histidine modification (GO:0018202)2.54260905
146cilium morphogenesis (GO:0060271)2.53980829
147chromatin remodeling at centromere (GO:0031055)2.53841169
148eye photoreceptor cell differentiation (GO:0001754)2.53367426
149photoreceptor cell differentiation (GO:0046530)2.53367426
150positive regulation of respiratory burst (GO:0060267)2.53153983
151organelle disassembly (GO:1903008)2.51480775
152drug catabolic process (GO:0042737)2.51169704
153ubiquinone metabolic process (GO:0006743)2.50774338
154platelet dense granule organization (GO:0060155)2.50612272
155tryptophan metabolic process (GO:0006568)2.48528437
156ribosomal large subunit biogenesis (GO:0042273)2.47578138
157regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.46961521
158cilium movement (GO:0003341)2.46655156
159response to protozoan (GO:0001562)2.46559544
160mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.46132851
161epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.45847025
162respiratory electron transport chain (GO:0022904)2.45589630
163RNA destabilization (GO:0050779)2.45409687
164hindbrain development (GO:0030902)2.44829497
165electron transport chain (GO:0022900)2.44262097
166photoreceptor cell maintenance (GO:0045494)2.43669607
167ear development (GO:0043583)2.42964670
168sphingomyelin metabolic process (GO:0006684)2.41826448
169positive regulation of glial cell differentiation (GO:0045687)2.41147511
170centriole replication (GO:0007099)2.40542206
171mitochondrial respiratory chain complex assembly (GO:0033108)2.39224037
172negative regulation of telomere maintenance (GO:0032205)2.38353165
173CENP-A containing nucleosome assembly (GO:0034080)2.38106343
174retinal cone cell development (GO:0046549)2.35090096
175kynurenine metabolic process (GO:0070189)2.32605793
176histone H2A acetylation (GO:0043968)2.32289370
177regulation of telomere maintenance (GO:0032204)2.31944097
178DNA demethylation (GO:0080111)2.28952492

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.54941598
2IGF1R_20145208_ChIP-Seq_DFB_Human3.41189099
3* ZFP57_27257070_Chip-Seq_ESCs_Mouse3.34599568
4ZNF274_21170338_ChIP-Seq_K562_Hela3.29344208
5TAF15_26573619_Chip-Seq_HEK293_Human3.25286610
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.18059603
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.98138785
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.95905498
9GBX2_23144817_ChIP-Seq_PC3_Human2.94967468
10FUS_26573619_Chip-Seq_HEK293_Human2.56851980
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.56294809
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.38091910
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.32745447
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.26924537
15IRF8_21731497_ChIP-ChIP_J774_Mouse2.23382641
16PCGF2_27294783_Chip-Seq_ESCs_Mouse2.22829227
17* GABP_17652178_ChIP-ChIP_JURKAT_Human2.22582274
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.21961140
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.13139749
20POU5F1_16153702_ChIP-ChIP_HESCs_Human2.06061011
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98278748
22CBX2_27304074_Chip-Seq_ESCs_Mouse1.95998819
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.94752673
24TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.87009026
25P300_19829295_ChIP-Seq_ESCs_Human1.86784953
26IRF1_19129219_ChIP-ChIP_H3396_Human1.85565071
27BMI1_23680149_ChIP-Seq_NPCS_Mouse1.78732980
28UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.71486720
29IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.70677542
30* VDR_23849224_ChIP-Seq_CD4+_Human1.68960306
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.67621749
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.67476655
33SMAD_19615063_ChIP-ChIP_OVARY_Human1.60522230
34EWS_26573619_Chip-Seq_HEK293_Human1.60208919
35MYC_18940864_ChIP-ChIP_HL60_Human1.58800979
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.55896623
37MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.55832028
38SUZ12_27294783_Chip-Seq_NPCs_Mouse1.54803042
39* NANOG_18555785_Chip-Seq_ESCs_Mouse1.54524333
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53884449
41* CBP_20019798_ChIP-Seq_JUKART_Human1.52242650
42* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.52242650
43VDR_22108803_ChIP-Seq_LS180_Human1.52030044
44RNF2_27304074_Chip-Seq_NSC_Mouse1.51196730
45SUZ12_18555785_Chip-Seq_ESCs_Mouse1.49620154
46* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.48204880
47TAL1_26923725_Chip-Seq_HPCs_Mouse1.47879419
48ER_23166858_ChIP-Seq_MCF-7_Human1.47631493
49NFE2_27457419_Chip-Seq_LIVER_Mouse1.46958375
50SMAD4_21799915_ChIP-Seq_A2780_Human1.43926998
51TP53_22573176_ChIP-Seq_HFKS_Human1.43564550
52* STAT3_18555785_Chip-Seq_ESCs_Mouse1.43542371
53BCAT_22108803_ChIP-Seq_LS180_Human1.43412770
54* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.41874866
55BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.41139082
56* P300_18555785_Chip-Seq_ESCs_Mouse1.40766467
57* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.40209958
58Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.39760554
59* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.39322355
60EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.38657476
61* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38135967
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.37844192
63EZH2_27294783_Chip-Seq_NPCs_Mouse1.36130988
64* E2F1_18555785_Chip-Seq_ESCs_Mouse1.36036782
65RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.36023460
66NOTCH1_21737748_ChIP-Seq_TLL_Human1.35791654
67KDM2B_26808549_Chip-Seq_REH_Human1.34752059
68* CMYC_18555785_Chip-Seq_ESCs_Mouse1.32277207
69PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32221401
70STAT3_23295773_ChIP-Seq_U87_Human1.31174928
71* P53_22387025_ChIP-Seq_ESCs_Mouse1.31132656
72* SOX2_18555785_Chip-Seq_ESCs_Mouse1.31048831
73AR_25329375_ChIP-Seq_VCAP_Human1.29702097
74ELK1_19687146_ChIP-ChIP_HELA_Human1.28524046
75SOX2_19829295_ChIP-Seq_ESCs_Human1.28379512
76NANOG_19829295_ChIP-Seq_ESCs_Human1.28379512
77PADI4_21655091_ChIP-ChIP_MCF-7_Human1.28237481
78FOXP3_21729870_ChIP-Seq_TREG_Human1.27800644
79ETS1_20019798_ChIP-Seq_JURKAT_Human1.27433160
80PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.27054153
81PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26972691
82SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26423658
83EZH2_22144423_ChIP-Seq_EOC_Human1.26368893
84RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.26201376
85TCF4_23295773_ChIP-Seq_U87_Human1.25960194
86* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.25196551
87SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25039181
88EED_16625203_ChIP-ChIP_MESCs_Mouse1.24365197
89IRF8_22096565_ChIP-ChIP_GC-B_Human1.24236834
90OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24213493
91KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23310022
92KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.23141864
93JARID2_20064375_ChIP-Seq_MESCs_Mouse1.22194424
94AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21934854
95HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.21128300
96* OCT4_18555785_Chip-Seq_ESCs_Mouse1.21109636
97IRF8_27001747_Chip-Seq_BMDM_Mouse1.19871172
98PIAS1_25552417_ChIP-Seq_VCAP_Human1.19596093
99EZH2_27304074_Chip-Seq_ESCs_Mouse1.19542964
100NMYC_18555785_Chip-Seq_ESCs_Mouse1.19486968
101PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.19282270
102TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19099881
103POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19099881
104EST1_17652178_ChIP-ChIP_JURKAT_Human1.18620393
105SOX2_16153702_ChIP-ChIP_HESCs_Human1.18424883
106E2F4_17652178_ChIP-ChIP_JURKAT_Human1.18059425
107MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18003057
108* PU1_27457419_Chip-Seq_LIVER_Mouse1.17852724
109STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.17732280
110TCF4_22108803_ChIP-Seq_LS180_Human1.16751448
111KLF4_18555785_Chip-Seq_ESCs_Mouse1.16149926
112SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.16112861
113EGR1_23403033_ChIP-Seq_LIVER_Mouse1.15548040
114SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.14833501
115EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.14348190
116RUNX2_22187159_ChIP-Seq_PCA_Human1.13910420
117* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.13405600
118* FOXA1_25329375_ChIP-Seq_VCAP_Human1.13405600
119* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.12935520
120SMAD1_18555785_Chip-Seq_ESCs_Mouse1.12897102
121* CTCF_18555785_Chip-Seq_ESCs_Mouse1.10499255
122SRF_21415370_ChIP-Seq_HL-1_Mouse1.10453208
123CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10184123
124PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10014919
125FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.09059353
126GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08610909
127TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08557500
128SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.07880263
129NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07779710
130CRX_20693478_ChIP-Seq_RETINA_Mouse1.07278921
131NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.07072808
132* ZFX_18555785_Chip-Seq_ESCs_Mouse1.06054872
133ELF1_17652178_ChIP-ChIP_JURKAT_Human1.04904588
134RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.04332607
135HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.03743903
136* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02507392
137FLI1_21867929_ChIP-Seq_TH2_Mouse1.01639228
138* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.01412176
139SMAD4_21741376_ChIP-Seq_EPCs_Human1.00876543
140CREB1_15753290_ChIP-ChIP_HEK293T_Human0.99139618
141NCOR_22424771_ChIP-Seq_293T_Human0.98724971
142FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.95997497
143TP63_19390658_ChIP-ChIP_HaCaT_Human0.95653842

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.53398502
2MP0002396_abnormal_hematopoietic_system4.44113369
3MP0000015_abnormal_ear_pigmentation3.99866018
4MP0008058_abnormal_DNA_repair3.55828753
5MP0009379_abnormal_foot_pigmentation3.40276132
6MP0003195_calcinosis3.33689762
7MP0008877_abnormal_DNA_methylation3.30864178
8MP0005174_abnormal_tail_pigmentation3.02765640
9MP0003718_maternal_effect2.96361293
10MP0001188_hyperpigmentation2.91033118
11MP0004510_myositis2.90763936
12MP0006292_abnormal_olfactory_placode2.82205649
13MP0003136_yellow_coat_color2.79507069
14MP0004381_abnormal_hair_follicle2.55431599
15MP0001879_abnormal_lymphatic_vessel2.48110522
16MP0008057_abnormal_DNA_replication2.30618508
17MP0005423_abnormal_somatic_nervous2.16287232
18MP0005409_darkened_coat_color2.14937884
19MP0003787_abnormal_imprinting2.14100496
20MP0006072_abnormal_retinal_apoptosis2.07838884
21MP0002095_abnormal_skin_pigmentation1.91046288
22MP0002837_dystrophic_cardiac_calcinosis1.85430556
23MP0005171_absent_coat_pigmentation1.80004174
24MP0003121_genomic_imprinting1.73065861
25MP0005253_abnormal_eye_physiology1.66181968
26MP0002234_abnormal_pharynx_morphology1.60707434
27MP0000631_abnormal_neuroendocrine_gland1.58317832
28MP0005645_abnormal_hypothalamus_physiol1.56936874
29MP0009046_muscle_twitch1.56374962
30MP0004742_abnormal_vestibular_system1.55537879
31MP0003122_maternal_imprinting1.48821440
32MP0005646_abnormal_pituitary_gland1.48199609
33MP0006276_abnormal_autonomic_nervous1.48161762
34MP0002148_abnormal_hypersensitivity_rea1.46854037
35MP0008569_lethality_at_weaning1.46467981
36MP0000566_synostosis1.45326140
37MP0009697_abnormal_copulation1.45195188
38MP0005387_immune_system_phenotype1.42434798
39MP0001790_abnormal_immune_system1.42434798
40MP0001835_abnormal_antigen_presentation1.42331456
41MP0002736_abnormal_nociception_after1.40737646
42MP0004142_abnormal_muscle_tone1.40265048
43MP0008875_abnormal_xenobiotic_pharmacok1.40181590
44MP0002638_abnormal_pupillary_reflex1.40074794
45MP0001529_abnormal_vocalization1.34839554
46MP0001485_abnormal_pinna_reflex1.34525221
47MP0005464_abnormal_platelet_physiology1.34249409
48MP0005671_abnormal_response_to1.34166430
49MP0008872_abnormal_physiological_respon1.32894811
50MP0000427_abnormal_hair_cycle1.31885155
51MP0004133_heterotaxia1.31335883
52MP0004885_abnormal_endolymph1.28304234
53MP0000569_abnormal_digit_pigmentation1.27656693
54MP0005085_abnormal_gallbladder_physiolo1.27259057
55MP0005058_abnormal_lysosome_morphology1.26907359
56MP0002419_abnormal_innate_immunity1.26414996
57MP0002160_abnormal_reproductive_system1.25011633
58MP0005389_reproductive_system_phenotype1.25006347
59MP0003436_decreased_susceptibility_to1.24926932
60MP0000778_abnormal_nervous_system1.24451144
61MP0001929_abnormal_gametogenesis1.24124766
62MP0009780_abnormal_chondrocyte_physiolo1.22019071
63MP0005000_abnormal_immune_tolerance1.21249048
64MP0003890_abnormal_embryonic-extraembry1.21130088
65MP0001764_abnormal_homeostasis1.20958910
66MP0010094_abnormal_chromosome_stability1.17522148
67MP0002452_abnormal_antigen_presenting1.16912653
68MP0001873_stomach_inflammation1.16749797
69MP0005084_abnormal_gallbladder_morpholo1.16636639
70MP0002723_abnormal_immune_serum1.16589186
71MP0001486_abnormal_startle_reflex1.16526284
72MP0001905_abnormal_dopamine_level1.15446059
73MP0001984_abnormal_olfaction1.14591749
74MP0005187_abnormal_penis_morphology1.14472045
75MP0008995_early_reproductive_senescence1.14062404
76MP0002102_abnormal_ear_morphology1.14035518
77MP0005025_abnormal_response_to1.12758610
78MP0001800_abnormal_humoral_immune1.12496185
79MP0002210_abnormal_sex_determination1.12128613
80MP0003698_abnormal_male_reproductive1.12093751
81MP0000920_abnormal_myelination1.07844163
82MP0006035_abnormal_mitochondrial_morpho1.07779952
83MP0002653_abnormal_ependyma_morphology1.06503279
84MP0002277_abnormal_respiratory_mucosa1.06468095
85MP0002557_abnormal_social/conspecific_i1.04254331
86MP0000653_abnormal_sex_gland1.03807874
87MP0005075_abnormal_melanosome_morpholog1.03797972
88MP0002163_abnormal_gland_morphology1.03528829
89MP0003011_delayed_dark_adaptation1.02820065
90MP0005379_endocrine/exocrine_gland_phen1.02517820
91MP0005386_behavior/neurological_phenoty1.02206575
92MP0004924_abnormal_behavior1.02206575
93MP0009785_altered_susceptibility_to1.01906873
94MP0000685_abnormal_immune_system1.01573229
95MP0002420_abnormal_adaptive_immunity0.99694013
96MP0001819_abnormal_immune_cell0.99664759
97MP0000383_abnormal_hair_follicle0.99487870
98MP0001919_abnormal_reproductive_system0.99058160
99MP0003252_abnormal_bile_duct0.98240774
100MP0002177_abnormal_outer_ear0.97890710
101MP0005395_other_phenotype0.97833293
102MP0001145_abnormal_male_reproductive0.96495155
103MP0003724_increased_susceptibility_to0.95465268
104MP0002139_abnormal_hepatobiliary_system0.94326058
105MP0002572_abnormal_emotion/affect_behav0.93806531
106MP0004147_increased_porphyrin_level0.93412320
107MP0001501_abnormal_sleep_pattern0.93246385
108MP0003303_peritoneal_inflammation0.92092555
109MP0002064_seizures0.91809165
110MP0001663_abnormal_digestive_system0.91397810
111MP0000372_irregular_coat_pigmentation0.91156223
112MP0003567_abnormal_fetal_cardiomyocyte0.90865654
113MP0002272_abnormal_nervous_system0.90229211
114MP0001851_eye_inflammation0.89765442
115MP0002067_abnormal_sensory_capabilities0.89371441
116MP0000026_abnormal_inner_ear0.88186774
117MP0004215_abnormal_myocardial_fiber0.88048797
118MP0005551_abnormal_eye_electrophysiolog0.87982758
119MP0009745_abnormal_behavioral_response0.87422750
120MP0003172_abnormal_lysosome_physiology0.87176729
121MP0010155_abnormal_intestine_physiology0.85911420
122MP0006036_abnormal_mitochondrial_physio0.84694529
123MP0004134_abnormal_chest_morphology0.84660793
124MP0003937_abnormal_limbs/digits/tail_de0.83788557
125MP0003119_abnormal_digestive_system0.83367655
126MP0001986_abnormal_taste_sensitivity0.83329513
127MP0004043_abnormal_pH_regulation0.83172403
128MP0002938_white_spotting0.82823082
129MP0003786_premature_aging0.82643805
130MP0001346_abnormal_lacrimal_gland0.82002226
131MP0003283_abnormal_digestive_organ0.81867149
132MP0003646_muscle_fatigue0.81560139
133MP0002751_abnormal_autonomic_nervous0.81262102
134MP0005451_abnormal_body_composition0.80399270
135MP0001963_abnormal_hearing_physiology0.80365536
136MP0008789_abnormal_olfactory_epithelium0.80194857
137MP0002735_abnormal_chemical_nociception0.78677599
138MP0005408_hypopigmentation0.78592338
139MP0002876_abnormal_thyroid_physiology0.78174568
140MP0002138_abnormal_hepatobiliary_system0.77761920
141MP0005394_taste/olfaction_phenotype0.76089295
142MP0005499_abnormal_olfactory_system0.76089295
143MP0002405_respiratory_system_inflammati0.74161255
144MP0005410_abnormal_fertilization0.72094103
145MP0003690_abnormal_glial_cell0.70271713
146MP0003950_abnormal_plasma_membrane0.69970555
147MP0001968_abnormal_touch/_nociception0.68523858
148MP0003941_abnormal_skin_development0.68414606
149MP0003634_abnormal_glial_cell0.66297534
150MP0005381_digestive/alimentary_phenotyp0.66136957
151MP0000465_gastrointestinal_hemorrhage0.65923652
152MP0000049_abnormal_middle_ear0.63296431
153MP0000647_abnormal_sebaceous_gland0.63068540
154MP0003448_altered_tumor_morphology0.62909231

Predicted human phenotypes

RankGene SetZ-score
1Frequent falls (HP:0002359)5.39609821
2Aplasia cutis congenita (HP:0001057)4.72269945
3Recurrent abscess formation (HP:0002722)4.29766829
4Recurrent bacterial skin infections (HP:0005406)4.16056241
5Gaze-evoked nystagmus (HP:0000640)4.04942157
6Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)4.04635294
7Abnormal hair whorl (HP:0010721)3.82402010
8Eczematoid dermatitis (HP:0000976)3.79303845
9Molar tooth sign on MRI (HP:0002419)3.43930466
10Abnormality of midbrain morphology (HP:0002418)3.43930466
11Parakeratosis (HP:0001036)3.38817359
12Nephronophthisis (HP:0000090)3.30623097
13Abnormality of saccadic eye movements (HP:0000570)3.20247445
14Chronic obstructive pulmonary disease (HP:0006510)3.19470494
15Obstructive lung disease (HP:0006536)3.19470494
16Dysdiadochokinesis (HP:0002075)3.17542902
17Renal cortical cysts (HP:0000803)3.12986989
18Increased neuronal autofluorescent lipopigment (HP:0002074)3.06914910
19Abnormality of the renal cortex (HP:0011035)3.05260406
20Abnormal ciliary motility (HP:0012262)3.04121630
21Recurrent gram-negative bacterial infections (HP:0005420)3.02623260
22Acute necrotizing encephalopathy (HP:0006965)2.97744666
23Xerostomia (HP:0000217)2.94242623
24Abnormal respiratory motile cilium physiology (HP:0012261)2.88859497
25Retinal dysplasia (HP:0007973)2.85289693
26Abnormality of the renal medulla (HP:0100957)2.85046038
27Abnormal respiratory epithelium morphology (HP:0012253)2.78205598
28Abnormal respiratory motile cilium morphology (HP:0005938)2.78205598
29Increased hepatocellular lipid droplets (HP:0006565)2.75207035
30True hermaphroditism (HP:0010459)2.74283307
31Chronic hepatic failure (HP:0100626)2.74122565
32Sensory axonal neuropathy (HP:0003390)2.71357280
33Abnormality of macrophages (HP:0004311)2.70544755
34Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.69401341
35Mitochondrial inheritance (HP:0001427)2.66512756
36Impaired smooth pursuit (HP:0007772)2.60911268
37Vacuolated lymphocytes (HP:0001922)2.59167582
38Anomalous pulmonary venous return (HP:0010772)2.56301477
39Abnormality of the labia minora (HP:0012880)2.44819459
40Aplasia/Hypoplasia of the uvula (HP:0010293)2.44787517
41Recurrent skin infections (HP:0001581)2.42660332
42Methylmalonic acidemia (HP:0002912)2.41843104
43Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.40967128
44Intestinal atresia (HP:0011100)2.39843536
45Renal Fanconi syndrome (HP:0001994)2.39340089
46Stomatitis (HP:0010280)2.38996494
47Hyperglycinemia (HP:0002154)2.38491331
48Dynein arm defect of respiratory motile cilia (HP:0012255)2.37008085
49Absent/shortened dynein arms (HP:0200106)2.37008085
50Colon cancer (HP:0003003)2.34803847
51Hyperventilation (HP:0002883)2.33747726
52Mediastinal lymphadenopathy (HP:0100721)2.33438139
53Progressive macrocephaly (HP:0004481)2.30889865
54Increased cerebral lipofuscin (HP:0011813)2.29864045
55Progressive inability to walk (HP:0002505)2.27947360
56Hepatic necrosis (HP:0002605)2.26675677
57Lipid accumulation in hepatocytes (HP:0006561)2.26376337
58Oculomotor apraxia (HP:0000657)2.26075309
59Congenital stationary night blindness (HP:0007642)2.25707513
60Abnormality of the ileum (HP:0001549)2.24571641
61Aplasia/Hypoplasia of the tibia (HP:0005772)2.23682926
62Abnormality of the pulmonary veins (HP:0011718)2.23419101
63Abnormal mitochondria in muscle tissue (HP:0008316)2.21152900
64Meckel diverticulum (HP:0002245)2.20311162
65Rhinitis (HP:0012384)2.20200301
66Decreased central vision (HP:0007663)2.17807783
67Attenuation of retinal blood vessels (HP:0007843)2.17357964
68Bile duct proliferation (HP:0001408)2.15310645
69Abnormal biliary tract physiology (HP:0012439)2.15310645
703-Methylglutaconic aciduria (HP:0003535)2.13297554
71Optic disc pallor (HP:0000543)2.12606763
72Acute encephalopathy (HP:0006846)2.12411646
73Short tibia (HP:0005736)2.12238677
74Abnormality of chromosome stability (HP:0003220)2.12127801
75Abnormality of ocular smooth pursuit (HP:0000617)2.12116289
76Exertional dyspnea (HP:0002875)2.11494061
77Small epiphyses (HP:0010585)2.10750957
78Inability to walk (HP:0002540)2.08449181
79Abnormality of incisor morphology (HP:0011063)2.08355908
80Hepatocellular necrosis (HP:0001404)2.07104710
81Medial flaring of the eyebrow (HP:0010747)2.06599666
82Volvulus (HP:0002580)2.06438606
83Mixed hearing impairment (HP:0000410)2.06431644
84Hypothermia (HP:0002045)2.06015105
85Genital tract atresia (HP:0001827)2.05641905
86Cystic liver disease (HP:0006706)2.04406881
87Occipital encephalocele (HP:0002085)2.03436735
88Abolished electroretinogram (ERG) (HP:0000550)2.02796882
89Abnormality of alanine metabolism (HP:0010916)2.02520789
90Hyperalaninemia (HP:0003348)2.02520789
91Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.02520789
92Type II lissencephaly (HP:0007260)2.02217407
93Stomach cancer (HP:0012126)1.99137222
94Increased CSF lactate (HP:0002490)1.97179511
95Abnormality of renal resorption (HP:0011038)1.96515090
96Congenital ichthyosiform erythroderma (HP:0007431)1.96276920
97Hypokinesia (HP:0002375)1.95338033
98Postaxial foot polydactyly (HP:0001830)1.95166066
99Thyroiditis (HP:0100646)1.94779815
100Leukodystrophy (HP:0002415)1.94619045
101Elevated erythrocyte sedimentation rate (HP:0003565)1.94142111
102Methylmalonic aciduria (HP:0012120)1.93934681
103Oligodactyly (hands) (HP:0001180)1.93242871
104Tubulointerstitial nephritis (HP:0001970)1.93121917
105Vaginal atresia (HP:0000148)1.91706846
106Gingivitis (HP:0000230)1.89662003
107Pendular nystagmus (HP:0012043)1.89106769
108Abnormality of urine glucose concentration (HP:0011016)1.88847274
109Glycosuria (HP:0003076)1.88847274
110Postaxial hand polydactyly (HP:0001162)1.88765498
111Abnormality of the pons (HP:0007361)1.86135015
112Infantile muscular hypotonia (HP:0008947)1.86025181
113Pancreatic fibrosis (HP:0100732)1.86010867
114Preaxial hand polydactyly (HP:0001177)1.85925457
115Aplasia/Hypoplasia of the tongue (HP:0010295)1.85682398
116Joint hemorrhage (HP:0005261)1.84743004
117Hypoplasia of the pons (HP:0012110)1.83454776
118Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.83139630
119Febrile seizures (HP:0002373)1.82892639
120Anencephaly (HP:0002323)1.82151240
121Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.81839738
122Optic nerve hypoplasia (HP:0000609)1.81173690
123Large for gestational age (HP:0001520)1.80437175
124Overfolded helix (HP:0000396)1.80296555
125Congenital hepatic fibrosis (HP:0002612)1.79626681
126Broad-based gait (HP:0002136)1.78575208
127Cerebral edema (HP:0002181)1.78456888
128Generalized aminoaciduria (HP:0002909)1.78217137
129Meningocele (HP:0002435)1.77970452
130Lip pit (HP:0100267)1.77967067
131Neonatal respiratory distress (HP:0002643)1.77149214
132Abnormal drinking behavior (HP:0030082)1.76447799
133Polydipsia (HP:0001959)1.76447799
134Congenital, generalized hypertrichosis (HP:0004540)1.75697202
135Hyperglycinuria (HP:0003108)1.74817876
136Gastrointestinal atresia (HP:0002589)1.74740056
137Epiphyseal dysplasia (HP:0002656)1.74033747
138Sclerocornea (HP:0000647)1.73927460
139Gait imbalance (HP:0002141)1.73255878
140Hypoglycemic coma (HP:0001325)1.72845802
141Abnormality of the preputium (HP:0100587)1.72482657
142Sloping forehead (HP:0000340)1.70904247
143Pancreatic cysts (HP:0001737)1.70686220
144Poor coordination (HP:0002370)1.70385321
145Congenital primary aphakia (HP:0007707)1.70246525
146Increased serum lactate (HP:0002151)1.70244387
147Hepatosplenomegaly (HP:0001433)1.69376569
148Lissencephaly (HP:0001339)1.68961715
149Abnormality of secondary sexual hair (HP:0009888)1.68411581
150Abnormality of the axillary hair (HP:0100134)1.68411581
151Cerebellar dysplasia (HP:0007033)1.67886964
152Type I transferrin isoform profile (HP:0003642)1.67861004
153Nephrogenic diabetes insipidus (HP:0009806)1.67420081
154Abnormality of serine family amino acid metabolism (HP:0010894)1.67262434
155Abnormality of glycine metabolism (HP:0010895)1.67262434
156Pulmonary artery stenosis (HP:0004415)1.66735562
157Patchy hypopigmentation of hair (HP:0011365)1.66178764
158IgG deficiency (HP:0004315)1.66142112
159Conical tooth (HP:0000698)1.65737017
160Ketosis (HP:0001946)1.65515735
161Abnormality of serum amino acid levels (HP:0003112)1.65225247
162Furrowed tongue (HP:0000221)1.64743788
163Spondylolisthesis (HP:0003302)1.64447788
164Chromsome breakage (HP:0040012)1.64320561
165Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.63736347
166Chromosomal breakage induced by crosslinking agents (HP:0003221)1.63660964
167Abnormal rod and cone electroretinograms (HP:0008323)1.63075050
168Recurrent pneumonia (HP:0006532)1.63054203
169Abnormally folded helix (HP:0008544)1.60307078
170Male pseudohermaphroditism (HP:0000037)1.59524650

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.19157532
2MST44.16488880
3BUB14.00241679
4MAP4K23.46361337
5BMPR1B3.39196862
6CASK3.38762012
7WNK32.92003350
8MAP3K142.67747831
9NUAK12.54374423
10PBK2.50784713
11CDK192.23437030
12PNCK2.22738948
13PINK12.02713051
14BLK1.95486375
15ADRBK21.91665878
16STK391.89654468
17INSRR1.84763991
18TNIK1.83135378
19ACVR1B1.77292930
20MAP3K41.70142375
21PLK41.69567159
22CDC71.66120256
23EIF2AK31.64285963
24IRAK31.61230636
25IKBKE1.60172529
26OXSR11.59045630
27IKBKB1.52022281
28ERBB31.51704607
29RIPK41.49767272
30MKNK21.49051359
31MAP3K121.45729841
32TXK1.44309197
33TRIM281.43873802
34TAOK31.40926198
35KIT1.38205876
36UHMK11.35352748
37CSNK1G31.34977475
38MKNK11.33514563
39TYK21.33188252
40TIE11.32545912
41CSNK1A1L1.31178633
42BCR1.29044296
43PKN11.26774395
44BMPR21.25045363
45FES1.14729973
46MAP3K131.11159360
47PLK31.10724336
48EIF2AK21.10189952
49BRSK21.09763337
50FGFR21.07674682
51WEE11.05044577
52DYRK21.02635709
53PIM21.02199672
54YES11.00500076
55TEC1.00400416
56GRK70.99086734
57CSNK1D0.99010532
58PAK30.98804605
59CCNB10.97837160
60NTRK30.97281523
61STK38L0.96913671
62IRAK40.96499179
63MAPK150.95049746
64TRPM70.94307875
65PLK20.91816210
66EPHA40.90021631
67NTRK20.89954325
68SRPK10.87452749
69CSNK1G10.85513221
70MARK10.85297753
71ABL20.84719392
72LATS10.84119072
73STK30.80401467
74VRK10.79703875
75SYK0.78402647
76NEK20.77876183
77NME10.77112705
78TSSK60.76610482
79DYRK30.76286242
80VRK20.76266130
81CSNK1G20.75818890
82CDK80.75745056
83TAF10.73718416
84CAMK2B0.73588879
85LCK0.73154140
86TGFBR10.71455198
87NTRK10.71130674
88LYN0.71012424
89GRK10.69911220
90PLK10.69335302
91PRKCE0.67150555
92ZAK0.67031582
93ATR0.65305585
94NME20.64413268
95TLK10.64156492
96MAPK130.63800935
97NEK10.61860552
98ATM0.61465350
99BCKDK0.60305739
100MAPK40.58519441
101CSNK2A20.57242861
102IRAK10.54630009
103BRD40.53263311
104PRPF4B0.52484653
105PRKCQ0.52356531
106CDK30.52349546
107PASK0.52347407
108CAMK2D0.51750939
109WNK40.50959288
110PRKG10.50328689
111TTK0.48899432
112MAP4K10.48802511
113CAMK2A0.48660370
114CAMKK10.47137346
115ARAF0.46507686
116NLK0.45759429
117CSNK1A10.44492443
118EIF2AK10.43633400
119MAP3K70.43631228
120RPS6KC10.42737267
121RPS6KL10.42737267
122PRKCG0.42197205
123STK160.42061405
124CSNK2A10.41864201
125PHKG10.41451031
126PHKG20.41451031
127PRKCD0.40884222
128TBK10.40768856
129RPS6KA50.40684785
130CHEK20.39693100
131PRKACA0.39540867
132RPS6KA60.39110062
133CDK70.39091735
134MAP2K70.38852092
135ADRBK10.38622479
136FLT30.37892578
137PRKACB0.37825807
138CSK0.37663578
139ABL10.36693736
140ITK0.36038297
141TNK20.35681934
142MAPKAPK50.35463261
143OBSCN0.35311162
144BTK0.35296321
145NEK60.34907580
146MUSK0.33410159
147CSNK1E0.33202010
148CAMK2G0.32127912
149RPS6KA40.31433123
150STK40.31016874
151PRKCA0.30984306
152PRKDC0.30257512

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034507.02075114
2Homologous recombination_Homo sapiens_hsa034404.18490428
3Ribosome_Homo sapiens_hsa030102.87131386
4Oxidative phosphorylation_Homo sapiens_hsa001902.69982016
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.48912265
6Butanoate metabolism_Homo sapiens_hsa006502.43347143
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.34631935
8Sulfur metabolism_Homo sapiens_hsa009202.32277410
9Propanoate metabolism_Homo sapiens_hsa006402.00753047
10Protein export_Homo sapiens_hsa030601.87795633
11RNA polymerase_Homo sapiens_hsa030201.87164282
12Parkinsons disease_Homo sapiens_hsa050121.83268059
13Mismatch repair_Homo sapiens_hsa034301.79188985
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.76953454
15Autoimmune thyroid disease_Homo sapiens_hsa053201.75171702
16Alzheimers disease_Homo sapiens_hsa050101.72206426
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.72018606
18Allograft rejection_Homo sapiens_hsa053301.70582754
19Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.69304658
20Steroid biosynthesis_Homo sapiens_hsa001001.68039123
21Proteasome_Homo sapiens_hsa030501.67890571
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.64985560
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.64720102
24Caffeine metabolism_Homo sapiens_hsa002321.63294773
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.60850895
26Selenocompound metabolism_Homo sapiens_hsa004501.58039124
27Primary bile acid biosynthesis_Homo sapiens_hsa001201.44712413
28Huntingtons disease_Homo sapiens_hsa050161.44145991
29One carbon pool by folate_Homo sapiens_hsa006701.42678691
30Tryptophan metabolism_Homo sapiens_hsa003801.42560604
31Chemical carcinogenesis_Homo sapiens_hsa052041.42403410
32Rheumatoid arthritis_Homo sapiens_hsa053231.40958733
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.37723640
34Peroxisome_Homo sapiens_hsa041461.36678861
35Dorso-ventral axis formation_Homo sapiens_hsa043201.35060900
36Retinol metabolism_Homo sapiens_hsa008301.35056076
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.34462334
38Nucleotide excision repair_Homo sapiens_hsa034201.34136047
39Nicotine addiction_Homo sapiens_hsa050331.31241823
40Intestinal immune network for IgA production_Homo sapiens_hsa046721.29758791
41Fatty acid elongation_Homo sapiens_hsa000621.28730537
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.27235420
43Graft-versus-host disease_Homo sapiens_hsa053321.25172657
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.23657905
45Sphingolipid metabolism_Homo sapiens_hsa006001.23414249
46Osteoclast differentiation_Homo sapiens_hsa043801.20158829
47Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.18249965
48Leishmaniasis_Homo sapiens_hsa051401.16426088
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.16387507
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13139380
51NF-kappa B signaling pathway_Homo sapiens_hsa040641.10752579
52B cell receptor signaling pathway_Homo sapiens_hsa046621.10538684
53Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.10456213
54Nitrogen metabolism_Homo sapiens_hsa009101.10158510
55Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.09280610
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.09248758
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.07803121
58T cell receptor signaling pathway_Homo sapiens_hsa046601.06819687
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.06494002
60Basal transcription factors_Homo sapiens_hsa030221.06344029
61Olfactory transduction_Homo sapiens_hsa047401.06188561
62Spliceosome_Homo sapiens_hsa030401.04759191
63Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.04097613
64Phagosome_Homo sapiens_hsa041451.02986047
65RNA transport_Homo sapiens_hsa030131.01598620
66Hematopoietic cell lineage_Homo sapiens_hsa046400.98532409
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.97827194
68Ether lipid metabolism_Homo sapiens_hsa005650.97449083
69DNA replication_Homo sapiens_hsa030300.96911949
70Regulation of autophagy_Homo sapiens_hsa041400.95078553
71NOD-like receptor signaling pathway_Homo sapiens_hsa046210.93044727
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.92869168
73Collecting duct acid secretion_Homo sapiens_hsa049660.92007652
74Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.91760643
75Base excision repair_Homo sapiens_hsa034100.90930020
76Cysteine and methionine metabolism_Homo sapiens_hsa002700.87307621
77Primary immunodeficiency_Homo sapiens_hsa053400.86749608
78Measles_Homo sapiens_hsa051620.86553280
79ABC transporters_Homo sapiens_hsa020100.85355082
80Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.84479909
81Fanconi anemia pathway_Homo sapiens_hsa034600.83830479
82Glutamatergic synapse_Homo sapiens_hsa047240.78058632
83Cardiac muscle contraction_Homo sapiens_hsa042600.75651863
84beta-Alanine metabolism_Homo sapiens_hsa004100.75113702
85Phototransduction_Homo sapiens_hsa047440.73999811
86Fatty acid degradation_Homo sapiens_hsa000710.73999788
87RNA degradation_Homo sapiens_hsa030180.73983331
88Type I diabetes mellitus_Homo sapiens_hsa049400.72638286
89Renin-angiotensin system_Homo sapiens_hsa046140.72296694
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70218250
91Metabolic pathways_Homo sapiens_hsa011000.69799159
92Malaria_Homo sapiens_hsa051440.68187152
93Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.67118755
94Epstein-Barr virus infection_Homo sapiens_hsa051690.66640338
95Chemokine signaling pathway_Homo sapiens_hsa040620.65790032
96Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.65772549
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.63614435
98TNF signaling pathway_Homo sapiens_hsa046680.63588351
99Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.63324009
100Pyrimidine metabolism_Homo sapiens_hsa002400.63319127
101Apoptosis_Homo sapiens_hsa042100.60908016
102Axon guidance_Homo sapiens_hsa043600.60881881
103Serotonergic synapse_Homo sapiens_hsa047260.59145778
104Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58359207
105Circadian rhythm_Homo sapiens_hsa047100.58049399
106Histidine metabolism_Homo sapiens_hsa003400.55472997
107Folate biosynthesis_Homo sapiens_hsa007900.54967655
108Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54262889
109Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54161567
110Asthma_Homo sapiens_hsa053100.53604910
111Fatty acid metabolism_Homo sapiens_hsa012120.53482105
112African trypanosomiasis_Homo sapiens_hsa051430.53031109
113Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52767754
114Purine metabolism_Homo sapiens_hsa002300.52637914
115Renal cell carcinoma_Homo sapiens_hsa052110.52053849
116Morphine addiction_Homo sapiens_hsa050320.49693872
117Long-term depression_Homo sapiens_hsa047300.49458411
118Glutathione metabolism_Homo sapiens_hsa004800.48958255
119Insulin secretion_Homo sapiens_hsa049110.48909584
120Pyruvate metabolism_Homo sapiens_hsa006200.48866623
121Toll-like receptor signaling pathway_Homo sapiens_hsa046200.48733303
122Colorectal cancer_Homo sapiens_hsa052100.48213756
123Oocyte meiosis_Homo sapiens_hsa041140.46896213
124Staphylococcus aureus infection_Homo sapiens_hsa051500.46750657
125Tuberculosis_Homo sapiens_hsa051520.45953037
126Renin secretion_Homo sapiens_hsa049240.44547138
127Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43762809
128RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.43090411
129Arachidonic acid metabolism_Homo sapiens_hsa005900.42389861
130Circadian entrainment_Homo sapiens_hsa047130.42348795
131Vitamin digestion and absorption_Homo sapiens_hsa049770.41530905
132Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.41524892
133mRNA surveillance pathway_Homo sapiens_hsa030150.41018734
134Linoleic acid metabolism_Homo sapiens_hsa005910.40929417
135Fat digestion and absorption_Homo sapiens_hsa049750.40630295
136Tyrosine metabolism_Homo sapiens_hsa003500.40129628
137Vitamin B6 metabolism_Homo sapiens_hsa007500.39701007
138Vibrio cholerae infection_Homo sapiens_hsa051100.37834317
139Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37506844
140Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36254141
141GABAergic synapse_Homo sapiens_hsa047270.35959678
142Taste transduction_Homo sapiens_hsa047420.35930254
143Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.35305982
144Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32847154
145Inositol phosphate metabolism_Homo sapiens_hsa005620.31700229
146Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.31407962
147Systemic lupus erythematosus_Homo sapiens_hsa053220.31205938
148Ras signaling pathway_Homo sapiens_hsa040140.30457662
149Steroid hormone biosynthesis_Homo sapiens_hsa001400.30172981
150Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.29214388
151SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28303843
152Leukocyte transendothelial migration_Homo sapiens_hsa046700.26272299
153Jak-STAT signaling pathway_Homo sapiens_hsa046300.25883520
154Alcoholism_Homo sapiens_hsa050340.25054118

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