NSUN4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)8.63408175
2chromosome condensation (GO:0030261)8.23343380
3DNA packaging (GO:0006323)8.16289441
4single strand break repair (GO:0000012)7.84124462
5microtubule depolymerization (GO:0007019)7.76044202
6piRNA metabolic process (GO:0034587)7.62701736
7sperm capacitation (GO:0048240)7.56370001
8protein polyglutamylation (GO:0018095)7.37034673
9spermatid nucleus differentiation (GO:0007289)7.03480528
10protein targeting to Golgi (GO:0000042)6.70933899
11cellular ketone body metabolic process (GO:0046950)6.63430856
12establishment of protein localization to Golgi (GO:0072600)6.63290440
13microtubule polymerization or depolymerization (GO:0031109)6.35203458
14phosphatidylethanolamine biosynthetic process (GO:0006646)6.24582328
15retrograde transport, vesicle recycling within Golgi (GO:0000301)6.22853085
16ketone body metabolic process (GO:1902224)5.96286540
17phosphatidylethanolamine metabolic process (GO:0046337)5.93298090
18male meiosis (GO:0007140)5.72353547
19multicellular organism reproduction (GO:0032504)5.71921778
20calcium ion-dependent exocytosis (GO:0017156)5.68269771
21microtubule severing (GO:0051013)5.41749897
22fusion of sperm to egg plasma membrane (GO:0007342)5.18157087
23regulation of centriole replication (GO:0046599)5.01011158
24sexual reproduction (GO:0019953)4.99892653
25protein localization to Golgi apparatus (GO:0034067)4.99243613
26regulation of RIG-I signaling pathway (GO:0039535)4.96921431
27regulation of meiosis I (GO:0060631)4.87985621
28DNA methylation involved in gamete generation (GO:0043046)4.77389501
29binding of sperm to zona pellucida (GO:0007339)4.75147586
30sperm-egg recognition (GO:0035036)4.68072811
31RNA destabilization (GO:0050779)4.65567034
32axonemal dynein complex assembly (GO:0070286)4.56541584
33sperm motility (GO:0030317)4.56376600
34negative regulation of inclusion body assembly (GO:0090084)4.53287027
35regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)4.44213024
36reproduction (GO:0000003)4.37036564
37germ cell development (GO:0007281)4.31694286
38epithelial cilium movement (GO:0003351)4.30988238
39regulation of cilium movement (GO:0003352)4.29629790
40seminiferous tubule development (GO:0072520)4.27545737
41multicellular organismal reproductive process (GO:0048609)4.23445865
42regulation of female gonad development (GO:2000194)4.22901532
43regulation of Rab GTPase activity (GO:0032313)4.21994042
44positive regulation of Rab GTPase activity (GO:0032851)4.21994042
45cell-cell recognition (GO:0009988)4.12509892
46plasma membrane fusion (GO:0045026)4.08577550
47single fertilization (GO:0007338)4.06845019
48motile cilium assembly (GO:0044458)4.06738611
49male meiosis I (GO:0007141)4.00940669
50cellular process involved in reproduction in multicellular organism (GO:0022412)3.96342046
51chromatin silencing (GO:0006342)3.96092025
52nucleus organization (GO:0006997)3.79673612
53glycerophospholipid catabolic process (GO:0046475)3.79030052
54meiotic chromosome segregation (GO:0045132)3.78970008
55regulation of histone H3-K27 methylation (GO:0061085)3.78493835
56cilium or flagellum-dependent cell motility (GO:0001539)3.78295744
57meiotic cell cycle (GO:0051321)3.77248193
58spermatid development (GO:0007286)3.71681670
59female gamete generation (GO:0007292)3.70600856
60oocyte maturation (GO:0001556)3.69464046
61base-excision repair, AP site formation (GO:0006285)3.69365099
62cilium movement (GO:0003341)3.68719631
63mitotic metaphase plate congression (GO:0007080)3.67172197
64microtubule nucleation (GO:0007020)3.66847714
65organic cation transport (GO:0015695)3.64976476
66regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.63463669
67regulation of meiosis (GO:0040020)3.56983864
68meiosis I (GO:0007127)3.56977543
69meiotic nuclear division (GO:0007126)3.55887822
70positive regulation of DNA-dependent DNA replication (GO:2000105)3.55060764
71regulation of transcription involved in cell fate commitment (GO:0060850)3.54978723
72fertilization (GO:0009566)3.53842866
73regulation of microtubule-based movement (GO:0060632)3.52618068
74regulation of relaxation of muscle (GO:1901077)3.51747230
75musculoskeletal movement (GO:0050881)3.49530402
76multicellular organismal movement (GO:0050879)3.49530402
77synaptonemal complex organization (GO:0070193)3.42899755
78monoubiquitinated protein deubiquitination (GO:0035520)3.42627995
79synaptonemal complex assembly (GO:0007130)3.42090791
80respiratory chain complex IV assembly (GO:0008535)3.36742776
81acrosome reaction (GO:0007340)3.36193024
82coenzyme catabolic process (GO:0009109)3.26555195
83carnitine shuttle (GO:0006853)3.21359882
84mitotic sister chromatid cohesion (GO:0007064)3.20854417
85ether metabolic process (GO:0018904)3.20665028
86gamete generation (GO:0007276)3.20473485
87chromatin remodeling at centromere (GO:0031055)3.16882063
88spermatogenesis (GO:0007283)3.16518552
89peptidyl-threonine dephosphorylation (GO:0035970)3.16298012
90male gamete generation (GO:0048232)3.16132911
91regulation of inclusion body assembly (GO:0090083)3.15152071
92negative regulation of Rho protein signal transduction (GO:0035024)3.14590038
93acrosome assembly (GO:0001675)3.11554892
94cell wall macromolecule metabolic process (GO:0044036)3.11039019
95cell wall macromolecule catabolic process (GO:0016998)3.11039019
96polyamine biosynthetic process (GO:0006596)3.09546547
97negative regulation of meiosis (GO:0045835)3.08054394
98chaperone-mediated protein transport (GO:0072321)3.07421705
99NAD biosynthetic process (GO:0009435)3.04827055
100CENP-A containing nucleosome assembly (GO:0034080)3.04531948
101histone exchange (GO:0043486)3.04163534
102histone mRNA catabolic process (GO:0071044)3.04113535
103cartilage morphogenesis (GO:0060536)3.03779792
104protein K6-linked ubiquitination (GO:0085020)3.03177432
105mitochondrial fission (GO:0000266)3.01780964
106DNA replication-independent nucleosome assembly (GO:0006336)3.01625347
107DNA replication-independent nucleosome organization (GO:0034724)3.01625347
108centriole replication (GO:0007099)3.00565359
109axoneme assembly (GO:0035082)2.99710562
110maturation of 5.8S rRNA (GO:0000460)2.99164689
111DNA conformation change (GO:0071103)2.98580346
112fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.98519771
113intra-Golgi vesicle-mediated transport (GO:0006891)2.96987038
114nucleosome disassembly (GO:0006337)2.96577190
115protein-DNA complex disassembly (GO:0032986)2.96577190
116DNA damage response, signal transduction resulting in transcription (GO:0042772)2.95716253
117sister chromatid cohesion (GO:0007062)2.93063802
118negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.92923799
119carnitine transmembrane transport (GO:1902603)2.92902207
120negative regulation of hormone biosynthetic process (GO:0032353)2.92147590
121negative regulation of hormone metabolic process (GO:0032351)2.92147590
122carnitine transport (GO:0015879)2.91746735
123amino-acid betaine transport (GO:0015838)2.91746735
124negative regulation of gene expression, epigenetic (GO:0045814)2.91156015
125metaphase plate congression (GO:0051310)2.91054463
126fatty acid transmembrane transport (GO:1902001)2.87445681
127nuclear pore complex assembly (GO:0051292)2.85629167
128positive regulation of megakaryocyte differentiation (GO:0045654)2.85535978
129DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.83493298
130ubiquinone biosynthetic process (GO:0006744)2.80883904
131quinone biosynthetic process (GO:1901663)2.80883904
132negative regulation of alcohol biosynthetic process (GO:1902931)2.80781455
133regulation of spindle organization (GO:0090224)2.79791065
134regulation of cell maturation (GO:1903429)2.79777312
135epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.79369977
136spinal cord motor neuron differentiation (GO:0021522)2.79172270
137female gonad development (GO:0008585)2.78442776
138multicellular organismal development (GO:0007275)2.78278691
139daunorubicin metabolic process (GO:0044597)2.78166876
140polyketide metabolic process (GO:0030638)2.78166876
141doxorubicin metabolic process (GO:0044598)2.78166876
142positive regulation of mitochondrial fission (GO:0090141)2.76971214
143detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.74241853
144peroxisome fission (GO:0016559)2.73959892
145membrane protein intracellular domain proteolysis (GO:0031293)2.73746781
146regulation of acrosome reaction (GO:0060046)2.72612057
147protein complex localization (GO:0031503)2.72168132
148regulation of spindle checkpoint (GO:0090231)2.71350855
149establishment of chromosome localization (GO:0051303)2.70490902
150glomerular visceral epithelial cell development (GO:0072015)2.70419207
151glycerol ether metabolic process (GO:0006662)2.68780505
152regulation of meiotic cell cycle (GO:0051445)2.68103221
153regulation of interleukin-13 production (GO:0032656)2.65502655
154phosphatidylglycerol biosynthetic process (GO:0006655)2.64161446
155centriole assembly (GO:0098534)2.63791760
156regulation of mitotic spindle organization (GO:0060236)2.63468064
157regulation of retinoic acid receptor signaling pathway (GO:0048385)2.61048571
158cytochrome complex assembly (GO:0017004)2.59925798
159cilium organization (GO:0044782)2.59425726
160gene silencing by RNA (GO:0031047)2.58297937
161Golgi to endosome transport (GO:0006895)2.57388493
162cilium assembly (GO:0042384)2.57201784
163centrosome duplication (GO:0051298)2.56200286
164cell recognition (GO:0008037)2.55238780
165regulation of centrosome duplication (GO:0010824)2.52618154
166tRNA methylation (GO:0030488)2.51378330
167antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.50016105

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.71746403
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.01361502
3KAP1_22055183_ChIP-Seq_ESCs_Mouse3.58199646
4FLI1_27457419_Chip-Seq_LIVER_Mouse3.28590398
5MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.19555352
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.17700909
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.08558659
8PCGF2_27294783_Chip-Seq_ESCs_Mouse2.94388731
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.80871060
10ZNF274_21170338_ChIP-Seq_K562_Hela2.75111950
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.66766114
12* EGR1_23403033_ChIP-Seq_LIVER_Mouse2.65863435
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.59413995
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.42135503
15IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.40328255
16CBP_20019798_ChIP-Seq_JUKART_Human2.40328255
17CTBP2_25329375_ChIP-Seq_LNCAP_Human2.39193079
18TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.31912399
19POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.31912399
20CTBP1_25329375_ChIP-Seq_LNCAP_Human2.30753140
21SMAD_19615063_ChIP-ChIP_OVARY_Human2.18236025
22ER_23166858_ChIP-Seq_MCF-7_Human2.14664850
23ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.09196305
24NFE2_27457419_Chip-Seq_LIVER_Mouse2.01226075
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.00137067
26SUZ12_27294783_Chip-Seq_NPCs_Mouse1.99832023
27ERA_21632823_ChIP-Seq_H3396_Human1.94610630
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.91496767
29RAC3_21632823_ChIP-Seq_H3396_Human1.85263412
30BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.84975847
31CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.81885969
32STAT1_17558387_ChIP-Seq_HELA_Human1.80006223
33VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.78789319
34E2F4_17652178_ChIP-ChIP_JURKAT_Human1.78271586
35* SRF_21415370_ChIP-Seq_HL-1_Mouse1.77079832
36UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.75405030
37TP63_19390658_ChIP-ChIP_HaCaT_Human1.73998817
38EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.73402295
39NANOG_20526341_ChIP-Seq_ESCs_Human1.73101467
40KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.72018664
41FOXM1_23109430_ChIP-Seq_U2OS_Human1.69958023
42RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.69216322
43ELF1_20517297_ChIP-Seq_JURKAT_Human1.66583229
44MYC_19829295_ChIP-Seq_ESCs_Human1.65524006
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.64609453
46RBPJ_22232070_ChIP-Seq_NCS_Mouse1.64197956
47EZH2_27294783_Chip-Seq_NPCs_Mouse1.63936089
48AR_21909140_ChIP-Seq_LNCAP_Human1.62344361
49EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.62064610
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.61965496
51PCGF2_27294783_Chip-Seq_NPCs_Mouse1.60293119
52P300_19829295_ChIP-Seq_ESCs_Human1.59218482
53ETV2_25802403_ChIP-Seq_MESCs_Mouse1.57085606
54* RBPJ_21746931_ChIP-Seq_IB4_Human1.55531279
55* TAF2_19829295_ChIP-Seq_ESCs_Human1.55135113
56WDR5_24793694_ChIP-Seq_LNCAP_Human1.54941426
57MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.54776217
58GATA3_21878914_ChIP-Seq_MCF-7_Human1.52023846
59EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.49178169
60SMAD4_21741376_ChIP-Seq_EPCs_Human1.46544396
61MYC_18940864_ChIP-ChIP_HL60_Human1.45924005
62GABP_17652178_ChIP-ChIP_JURKAT_Human1.45103116
63AR_25329375_ChIP-Seq_VCAP_Human1.44828734
64RUNX1_26923725_Chip-Seq_HPCs_Mouse1.44070000
65* ETV1_20927104_ChIP-Seq_GIST48_Human1.43106205
66* CBX2_22325352_ChIP-Seq_293T-Rex_Human1.42735947
67YY1_22570637_ChIP-Seq_MALME-3M_Human1.42397888
68* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.42328632
69OCT4_20526341_ChIP-Seq_ESCs_Human1.40691187
70TDRD3_21172665_ChIP-Seq_MCF-7_Human1.40591243
71GATA3_21867929_ChIP-Seq_TH1_Mouse1.38558428
72DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.38543615
73RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.37768515
74SOX2_19829295_ChIP-Seq_ESCs_Human1.36424697
75NANOG_19829295_ChIP-Seq_ESCs_Human1.36424697
76HOXB7_26014856_ChIP-Seq_BT474_Human1.36251618
77* NFYB_21822215_ChIP-Seq_K562_Human1.35237208
78IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.34208009
79MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.33658365
80SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32003707
81LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.30246626
82CRX_20693478_ChIP-Seq_RETINA_Mouse1.30113049
83PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.29846106
84KLF5_20875108_ChIP-Seq_MESCs_Mouse1.29730158
85RXR_22158963_ChIP-Seq_LIVER_Mouse1.29606940
86* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.29364620
87STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.29083425
88TAF15_26573619_Chip-Seq_HEK293_Human1.29021378
89STAT3_23295773_ChIP-Seq_U87_Human1.28772216
90EST1_17652178_ChIP-ChIP_JURKAT_Human1.28721800
91* GATA6_21074721_ChIP-Seq_CACO-2_Human1.28044577
92MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.27224365
93VDR_22108803_ChIP-Seq_LS180_Human1.26299403
94FOXA1_25329375_ChIP-Seq_VCAP_Human1.26040628
95FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26040628
96NANOG_18555785_Chip-Seq_ESCs_Mouse1.26037523
97CEBPB_22108803_ChIP-Seq_LS180_Human1.25951697
98STAT3_18555785_Chip-Seq_ESCs_Mouse1.24869321
99E2F1_20622854_ChIP-Seq_HELA_Human1.24570689
100PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.24564328
101P53_21459846_ChIP-Seq_SAOS-2_Human1.24181216
102PHF8_20622854_ChIP-Seq_HELA_Human1.23945162
103CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.23782302
104NCOR_22424771_ChIP-Seq_293T_Human1.23366587
105PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.21537955
106ARNT_22903824_ChIP-Seq_MCF-7_Human1.18965449
107* TBL1_22424771_ChIP-Seq_293T_Human1.18904450
108FOXA1_21572438_ChIP-Seq_LNCaP_Human1.18205092
109* GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.18182459
110CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.18145970
111SMAD3_21741376_ChIP-Seq_EPCs_Human1.17606673
112SMRT_27268052_Chip-Seq_Bcells_Human1.16114666
113P300_27268052_Chip-Seq_Bcells_Human1.15894178
114EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.15623899
115BCL6_27268052_Chip-Seq_Bcells_Human1.15481666
116CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15144925
117PPARA_22158963_ChIP-Seq_LIVER_Mouse1.14912487
118* PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.13755046
119TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13629377
120SMAD4_21799915_ChIP-Seq_A2780_Human1.13428715
121ERG_20517297_ChIP-Seq_VCAP_Human1.13362792
122CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.13342924
123GBX2_23144817_ChIP-Seq_PC3_Human1.12904510
124IRF8_21731497_ChIP-ChIP_J774_Mouse1.12573945
125TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12277653
126EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.12256091
127CTCF_20526341_ChIP-Seq_ESCs_Human1.12061850
128EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12026790
129SCL_19346495_ChIP-Seq_HPC-7_Human1.10897135
130P53_22387025_ChIP-Seq_ESCs_Mouse1.10825691
131LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10157081
132RUNX2_22187159_ChIP-Seq_PCA_Human1.09454694
133NANOG_18555785_ChIP-Seq_MESCs_Mouse1.09247475
134E2F1_17053090_ChIP-ChIP_MCF-7_Human1.09008554
135IRF8_22096565_ChIP-ChIP_GC-B_Human1.08975596
136OCT4_21477851_ChIP-Seq_ESCs_Mouse1.08468056
137* NFYA_21822215_ChIP-Seq_K562_Human1.08015107
138SMAD3_21741376_ChIP-Seq_ESCs_Human1.07226411
139HOXB4_20404135_ChIP-ChIP_EML_Mouse1.07160002
140NMYC_18555785_Chip-Seq_ESCs_Mouse1.06726262
141HTT_18923047_ChIP-ChIP_STHdh_Human1.06407326
142AUTS2_25519132_ChIP-Seq_293T-REX_Human1.05123499
143* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.04639819
144BCOR_27268052_Chip-Seq_Bcells_Human1.04603528
145CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.04164571
146RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03606286
147OCT4_18555785_Chip-Seq_ESCs_Mouse1.02812689
148* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02617803
149SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02491954
150E2F1_21310950_ChIP-Seq_MCF-7_Human1.02482088
151SALL1_21062744_ChIP-ChIP_HESCs_Human1.02051182
152TCF4_23295773_ChIP-Seq_U87_Human1.01505051
153NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.00541512
154EP300_21415370_ChIP-Seq_HL-1_Mouse1.00115494
155FUS_26573619_Chip-Seq_HEK293_Human0.99597279
156ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99388890
157AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99071387
158EZH2_22144423_ChIP-Seq_EOC_Human0.99059507
159KLF4_18555785_Chip-Seq_ESCs_Mouse0.99014848
160* SALL4_22934838_ChIP-ChIP_CD34+_Human0.98707878
161FOXH1_21741376_ChIP-Seq_EPCs_Human0.98431159
162SOX2_22085726_ChIP-Seq_NPCs_Mouse0.97436771
163ZFX_18555785_Chip-Seq_ESCs_Mouse0.97384532
164* TAL1_26923725_Chip-Seq_HPCs_Mouse0.96804361
165VDR_23849224_ChIP-Seq_CD4+_Human0.95673553
166CMYC_18555785_Chip-Seq_ESCs_Mouse0.95636472
167PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95635763
168RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.95396172
169GATA3_26560356_Chip-Seq_TH1_Human0.95218757
170ESET_19884257_ChIP-Seq_ESCs_Mouse0.95134327
171* HNFA_21074721_ChIP-Seq_CACO-2_Human0.94872969
172NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.94805167
173KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.94362583
174LXR_22158963_ChIP-Seq_LIVER_Mouse0.94230507
175SOX2_18555785_Chip-Seq_ESCs_Mouse0.93335940
176CTCF_18555785_Chip-Seq_ESCs_Mouse0.92874665
177SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.92801855
178* IRF1_19129219_ChIP-ChIP_H3396_Human0.92707140
179* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.92593094
180* PHF8_20622853_ChIP-Seq_HELA_Human0.92565147
181GATA3_21867929_ChIP-Seq_CD8_Mouse0.92068113
182LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92024935
183SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.91866043
184ESRRB_18555785_Chip-Seq_ESCs_Mouse0.91564975

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue6.16828225
2MP0003878_abnormal_ear_physiology4.01198920
3MP0005377_hearing/vestibular/ear_phenot4.01198920
4MP0005410_abnormal_fertilization3.88000561
5MP0003718_maternal_effect3.46294180
6MP0005451_abnormal_body_composition3.41869671
7MP0002102_abnormal_ear_morphology3.20157303
8MP0008877_abnormal_DNA_methylation3.07666916
9MP0002139_abnormal_hepatobiliary_system3.06760836
10MP0001348_abnormal_lacrimal_gland2.83585000
11MP0001929_abnormal_gametogenesis2.82896519
12MP0008875_abnormal_xenobiotic_pharmacok2.62347826
13MP0005360_urolithiasis2.56722324
14MP0010094_abnormal_chromosome_stability2.42425615
15MP0002132_abnormal_respiratory_system2.30633718
16MP0003693_abnormal_embryo_hatching2.18604104
17MP0005379_endocrine/exocrine_gland_phen2.10233275
18MP0002210_abnormal_sex_determination2.05059051
19MP0002653_abnormal_ependyma_morphology2.01080412
20MP0003698_abnormal_male_reproductive2.00716501
21MP0002837_dystrophic_cardiac_calcinosis1.99495750
22MP0005670_abnormal_white_adipose1.93064530
23MP0000653_abnormal_sex_gland1.85981153
24MP0001119_abnormal_female_reproductive1.85077055
25MP0005365_abnormal_bile_salt1.81401080
26MP0002249_abnormal_larynx_morphology1.78314777
27MP0008057_abnormal_DNA_replication1.73452497
28MP0003077_abnormal_cell_cycle1.67892838
29MP0010368_abnormal_lymphatic_system1.64662811
30MP0003111_abnormal_nucleus_morphology1.60534043
31MP0003699_abnormal_female_reproductive1.60043447
32MP0001485_abnormal_pinna_reflex1.56428674
33MP0006036_abnormal_mitochondrial_physio1.56391606
34MP0005395_other_phenotype1.54285784
35MP0001145_abnormal_male_reproductive1.54009384
36MP0005408_hypopigmentation1.52472294
37MP0002161_abnormal_fertility/fecundity1.47325865
38MP0005253_abnormal_eye_physiology1.47058613
39MP0005551_abnormal_eye_electrophysiolog1.46732742
40MP0004782_abnormal_surfactant_physiolog1.45397599
41MP0004036_abnormal_muscle_relaxation1.40254826
42MP0005645_abnormal_hypothalamus_physiol1.39525628
43MP0005646_abnormal_pituitary_gland1.36451796
44MP0004957_abnormal_blastocyst_morpholog1.34340957
45MP0004742_abnormal_vestibular_system1.32790981
46MP0005085_abnormal_gallbladder_physiolo1.32397074
47MP0005266_abnormal_metabolism1.29103674
48MP0009697_abnormal_copulation1.25687888
49MP0008995_early_reproductive_senescence1.24250698
50MP0002282_abnormal_trachea_morphology1.24154232
51MP0006292_abnormal_olfactory_placode1.22288772
52MP0002234_abnormal_pharynx_morphology1.21602543
53MP0003786_premature_aging1.21191549
54MP0002160_abnormal_reproductive_system1.20164676
55MP0008007_abnormal_cellular_replicative1.18717835
56MP0004510_myositis1.18027776
57MP0003011_delayed_dark_adaptation1.17194963
58MP0002163_abnormal_gland_morphology1.14600757
59MP0000372_irregular_coat_pigmentation1.13839607
60MP0001968_abnormal_touch/_nociception1.13327021
61MP0005423_abnormal_somatic_nervous1.13117362
62MP0005389_reproductive_system_phenotype1.12885623
63MP0001486_abnormal_startle_reflex1.07853405
64MP0005647_abnormal_sex_gland1.06203065
65MP0003806_abnormal_nucleotide_metabolis1.02361193
66MP0002332_abnormal_exercise_endurance1.01876589
67MP0001873_stomach_inflammation1.01752862
68MP0003763_abnormal_thymus_physiology1.00988447
69MP0002229_neurodegeneration1.00824331
70MP0005083_abnormal_biliary_tract1.00763568
71MP0001919_abnormal_reproductive_system1.00567490
72MP0009115_abnormal_fat_cell1.00228016
73MP0004084_abnormal_cardiac_muscle0.99828386
74MP0001851_eye_inflammation0.99147563
75MP0002876_abnormal_thyroid_physiology0.96948573
76MP0005084_abnormal_gallbladder_morpholo0.96065333
77MP0006035_abnormal_mitochondrial_morpho0.95496759
78MP0008961_abnormal_basal_metabolism0.93300246
79MP0001765_abnormal_ion_homeostasis0.91348661
80MP0002735_abnormal_chemical_nociception0.91159731
81MP0003656_abnormal_erythrocyte_physiolo0.90359244
82MP0008932_abnormal_embryonic_tissue0.89870523
83MP0008058_abnormal_DNA_repair0.88701120
84MP0002928_abnormal_bile_duct0.88431536
85MP0004215_abnormal_myocardial_fiber0.87466215
86MP0001963_abnormal_hearing_physiology0.87298444
87MP0001915_intracranial_hemorrhage0.85832503
88MP0000015_abnormal_ear_pigmentation0.83077855
89MP0003186_abnormal_redox_activity0.82885436
90MP0005636_abnormal_mineral_homeostasis0.82772117
91MP0003123_paternal_imprinting0.80778696
92MP0002822_catalepsy0.80545659
93MP0001853_heart_inflammation0.80185373
94MP0002127_abnormal_cardiovascular_syste0.79952042
95MP0005367_renal/urinary_system_phenotyp0.76169676
96MP0000516_abnormal_urinary_system0.76169676
97MP0003136_yellow_coat_color0.76113533
98MP0004233_abnormal_muscle_weight0.75833171
99MP0001984_abnormal_olfaction0.75675020
100MP0002557_abnormal_social/conspecific_i0.75592021
101MP0005332_abnormal_amino_acid0.75591451
102MP0005330_cardiomyopathy0.75314910
103MP0000749_muscle_degeneration0.74269638
104MP0002067_abnormal_sensory_capabilities0.73975599
105MP0002269_muscular_atrophy0.72674970
106MP0001501_abnormal_sleep_pattern0.71984521
107MP0001905_abnormal_dopamine_level0.71158709
108MP0005319_abnormal_enzyme/_coenzyme0.70842023
109MP0002106_abnormal_muscle_physiology0.70580935
110MP0001346_abnormal_lacrimal_gland0.69013988
111MP0009046_muscle_twitch0.68998570
112MP0002877_abnormal_melanocyte_morpholog0.68619488
113MP0000026_abnormal_inner_ear0.67826672
114MP0003195_calcinosis0.67766859
115MP0005671_abnormal_response_to0.67048747
116MP0001529_abnormal_vocalization0.67035547
117MP0006072_abnormal_retinal_apoptosis0.66894587
118MP0000678_abnormal_parathyroid_gland0.66822412
119MP0003828_pulmonary_edema0.66656829
120MP0003950_abnormal_plasma_membrane0.65077778
121MP0008872_abnormal_physiological_respon0.64382659
122MP0005310_abnormal_salivary_gland0.63805764
123MP0002971_abnormal_brown_adipose0.63335314
124MP0009785_altered_susceptibility_to0.62747818
125MP0002095_abnormal_skin_pigmentation0.62354587
126MP0001800_abnormal_humoral_immune0.62150825
127MP0003252_abnormal_bile_duct0.62077754
128MP0000689_abnormal_spleen_morphology0.61526961
129MP0003724_increased_susceptibility_to0.61320972
130MP0001835_abnormal_antigen_presentation0.60696374
131MP0003221_abnormal_cardiomyocyte_apopto0.60608898
132MP0004085_abnormal_heartbeat0.60554256
133MP0009763_increased_sensitivity_to0.60277375
134MP0001764_abnormal_homeostasis0.59954848
135MP0002138_abnormal_hepatobiliary_system0.59707402
136MP0003787_abnormal_imprinting0.59628003
137MP0003937_abnormal_limbs/digits/tail_de0.59307467
138MP0005376_homeostasis/metabolism_phenot0.59044110
139MP0002693_abnormal_pancreas_physiology0.59036497
140MP0005385_cardiovascular_system_phenoty0.58710413
141MP0001544_abnormal_cardiovascular_syste0.58710413
142MP0000609_abnormal_liver_physiology0.57385563
143MP0002272_abnormal_nervous_system0.57345655
144MP0004484_altered_response_of0.57170334
145MP0000427_abnormal_hair_cycle0.56875756
146MP0005391_vision/eye_phenotype0.56499173
147MP0000613_abnormal_salivary_gland0.56230106
148MP0001270_distended_abdomen0.56020238
149MP0000955_abnormal_spinal_cord0.55730739
150MP0006276_abnormal_autonomic_nervous0.55538643
151MP0001944_abnormal_pancreas_morphology0.54653561
152MP0009745_abnormal_behavioral_response0.53789898
153MP0000371_diluted_coat_color0.53737415
154MP0000681_abnormal_thyroid_gland0.50922534
155MP0000631_abnormal_neuroendocrine_gland0.49991363
156MP0005167_abnormal_blood-brain_barrier0.47369992

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)7.07146877
2Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.17906276
3Chronic hepatic failure (HP:0100626)5.42567256
4Attenuation of retinal blood vessels (HP:0007843)5.10050997
5Bony spicule pigmentary retinopathy (HP:0007737)4.75868123
6Male infertility (HP:0003251)4.70550683
7Absent/shortened dynein arms (HP:0200106)4.53585444
8Dynein arm defect of respiratory motile cilia (HP:0012255)4.53585444
9Abnormal respiratory motile cilium physiology (HP:0012261)4.32368992
10Abnormal rod and cone electroretinograms (HP:0008323)4.17314890
11Infertility (HP:0000789)4.04952582
12Abnormality of macular pigmentation (HP:0008002)3.77826238
13Chronic bronchitis (HP:0004469)3.70254863
14Rhinitis (HP:0012384)3.66252769
15Hyperkalemia (HP:0002153)3.58917145
16Type 2 muscle fiber atrophy (HP:0003554)3.56117992
17Cone-rod dystrophy (HP:0000548)3.47961570
18Aplastic anemia (HP:0001915)3.35330077
19Renal cortical cysts (HP:0000803)3.29977494
20Aplasia/Hypoplasia of the earlobes (HP:0009906)3.16003744
21Abnormal spermatogenesis (HP:0008669)3.13871823
22Abnormal ciliary motility (HP:0012262)3.09819283
23Abnormal respiratory epithelium morphology (HP:0012253)3.05939997
24Abnormal respiratory motile cilium morphology (HP:0005938)3.05939997
25Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.04960383
26Adrenal hypoplasia (HP:0000835)3.03527222
27Weak cry (HP:0001612)2.97369422
28Muscle fiber atrophy (HP:0100295)2.96972050
29Bronchiectasis (HP:0002110)2.91781451
30Abnormal drinking behavior (HP:0030082)2.91563604
31Polydipsia (HP:0001959)2.91563604
32Nasal polyposis (HP:0100582)2.86424894
33Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.83556875
34Chromosomal breakage induced by crosslinking agents (HP:0003221)2.82052091
35Hypoplasia of the thymus (HP:0000778)2.81606613
36Progressive cerebellar ataxia (HP:0002073)2.79901476
37Abnormality of the renal cortex (HP:0011035)2.77104535
38Tubulointerstitial abnormality (HP:0001969)2.75835530
39Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.72532558
40Decreased activity of mitochondrial respiratory chain (HP:0008972)2.72532558
41Generalized aminoaciduria (HP:0002909)2.72530369
42Birth length less than 3rd percentile (HP:0003561)2.71089028
43Abnormality of lateral ventricle (HP:0030047)2.70671902
44Amelogenesis imperfecta (HP:0000705)2.69246095
45Resting tremor (HP:0002322)2.67030117
46Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.66325375
47Potter facies (HP:0002009)2.66308485
48Facial shape deformation (HP:0011334)2.66308485
49Abnormality of dental color (HP:0011073)2.66217376
50Hypoplastic ischia (HP:0003175)2.65636760
51Abnormal urine output (HP:0012590)2.65509899
52Chromsome breakage (HP:0040012)2.64608865
53Lipid accumulation in hepatocytes (HP:0006561)2.62223133
54Polyuria (HP:0000103)2.58077881
55Increased hepatocellular lipid droplets (HP:0006565)2.50804357
56Bronchitis (HP:0012387)2.50647360
57Tubular atrophy (HP:0000092)2.45758966
58Nephronophthisis (HP:0000090)2.43496078
59Bell-shaped thorax (HP:0001591)2.43086505
60Abnormality of the nasal mucosa (HP:0000433)2.41713377
61Abnormality of fatty-acid metabolism (HP:0004359)2.40853255
62Neonatal hypoglycemia (HP:0001998)2.39619868
63Stage 5 chronic kidney disease (HP:0003774)2.36817078
64Asymmetric septal hypertrophy (HP:0001670)2.34966362
65Tubulointerstitial nephritis (HP:0001970)2.34312712
66Optic neuritis (HP:0100653)2.32389813
67Retrobulbar optic neuritis (HP:0100654)2.32389813
68Hepatic necrosis (HP:0002605)2.29219936
69Azoospermia (HP:0000027)2.28832508
70Type II lissencephaly (HP:0007260)2.28259055
71Abnormality of the renal medulla (HP:0100957)2.28126683
72Rhabdomyolysis (HP:0003201)2.27848544
73Nonprogressive disorder (HP:0003680)2.26517421
74Abnormality of renal excretion (HP:0011036)2.26123072
75Hepatocellular necrosis (HP:0001404)2.23481550
76Pendular nystagmus (HP:0012043)2.21676823
77Congenital stationary night blindness (HP:0007642)2.21188115
78Decreased central vision (HP:0007663)2.20669021
79Exertional dyspnea (HP:0002875)2.19939013
80Truncal obesity (HP:0001956)2.19715484
81Abnormality of the ischium (HP:0003174)2.19533474
82Pulmonary fibrosis (HP:0002206)2.18989707
83Enlarged epiphyses (HP:0010580)2.18167553
84Abnormality of the parathyroid morphology (HP:0011766)2.16704723
85Molar tooth sign on MRI (HP:0002419)2.13752780
86Abnormality of midbrain morphology (HP:0002418)2.13752780
87Clubbing of toes (HP:0100760)2.12483303
88Portal hypertension (HP:0001409)2.07166759
89Abnormality of potassium homeostasis (HP:0011042)2.06307443
90Shawl scrotum (HP:0000049)2.05822983
91Fatigable weakness (HP:0003473)2.05077921
92Abnormality of the neuromuscular junction (HP:0003398)2.05077921
93Abnormality of urine glucose concentration (HP:0011016)2.03221878
94Glycosuria (HP:0003076)2.03221878
95Increased muscle lipid content (HP:0009058)2.02481206
96Respiratory difficulties (HP:0002880)2.02228948
97Progressive sensorineural hearing impairment (HP:0000408)2.01766957
98Insulin-resistant diabetes mellitus (HP:0000831)2.01500110
99Abnormality of placental membranes (HP:0011409)2.00830719
100Amniotic constriction ring (HP:0009775)2.00830719
101Cerebellar dysplasia (HP:0007033)2.00148858
102Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.97669730
103Menstrual irregularities (HP:0000858)1.96577213
104Aplasia/Hypoplasia of the uvula (HP:0010293)1.96307059
105Optic nerve hypoplasia (HP:0000609)1.95877022
106Abnormality of the hepatic vasculature (HP:0006707)1.94693273
107True hermaphroditism (HP:0010459)1.93238873
108Lipoatrophy (HP:0100578)1.92565411
109Increased intramyocellular lipid droplets (HP:0012240)1.92086137
110Congenital malformation of the right heart (HP:0011723)1.90571104
111Double outlet right ventricle (HP:0001719)1.90571104
112Bundle branch block (HP:0011710)1.90395248
113Meckel diverticulum (HP:0002245)1.89441480
114Brushfield spots (HP:0001088)1.88152325
115Hypoalphalipoproteinemia (HP:0003233)1.87693579
116Photophobia (HP:0000613)1.86595713
117Orchitis (HP:0100796)1.86476129
118Pancreatic fibrosis (HP:0100732)1.85999308
119Hypergonadotropic hypogonadism (HP:0000815)1.85605381
120Sclerocornea (HP:0000647)1.85542629
121Acute myeloid leukemia (HP:0004808)1.85302341
122Papillary thyroid carcinoma (HP:0002895)1.84916558
123Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.84717482
124Renovascular hypertension (HP:0100817)1.84634378
125Abnormality of the preputium (HP:0100587)1.84558071
126Facial diplegia (HP:0001349)1.83887674
127Intrahepatic cholestasis (HP:0001406)1.83531906
128Abnormal albumin level (HP:0012116)1.83379411
129Hypoalbuminemia (HP:0003073)1.83379411
130Renal dysplasia (HP:0000110)1.83238088
131Ketosis (HP:0001946)1.82954005
132Patellar aplasia (HP:0006443)1.82783772
133Postural instability (HP:0002172)1.82368260
134Hyperammonemia (HP:0001987)1.82285391
135Spontaneous abortion (HP:0005268)1.82256692
136Atrioventricular block (HP:0001678)1.81640675
137Lactic acidosis (HP:0003128)1.80412767
138Deep venous thrombosis (HP:0002625)1.80288544
139Abnormality of the aortic arch (HP:0012303)1.80185919
140Renal Fanconi syndrome (HP:0001994)1.80174829
141Unilateral renal agenesis (HP:0000122)1.80150753
142Abnormality of the ileum (HP:0001549)1.79581620
143Spondylolisthesis (HP:0003302)1.78862849
144Ragged-red muscle fibers (HP:0003200)1.78679708
145Bile duct proliferation (HP:0001408)1.78125666
146Abnormal biliary tract physiology (HP:0012439)1.78125666
147Impulsivity (HP:0100710)1.78076076
148Secondary amenorrhea (HP:0000869)1.77136427
149Abnormality of aromatic amino acid family metabolism (HP:0004338)1.76379109
150Aplasia/Hypoplasia of the patella (HP:0006498)1.75660879
151Atrial fibrillation (HP:0005110)1.74819298
152Sloping forehead (HP:0000340)1.74604193
153Upper limb muscle weakness (HP:0003484)1.73773606
154Congenital sensorineural hearing impairment (HP:0008527)1.73727517
155Ventricular tachycardia (HP:0004756)1.73673526
156Alveolar cell carcinoma (HP:0006519)1.72863875
157Pancreatic cysts (HP:0001737)1.72792324
158Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.72259211
159Occipital encephalocele (HP:0002085)1.71945275
160Abnormality of renal resorption (HP:0011038)1.71848291
161Medial flaring of the eyebrow (HP:0010747)1.71487977
162Tetany (HP:0001281)1.71224471
163Recurrent bronchitis (HP:0002837)1.70909024
164Myelodysplasia (HP:0002863)1.70490754
165Retinal dysplasia (HP:0007973)1.68745496
166Hypophosphatemic rickets (HP:0004912)1.68543076
167Type II diabetes mellitus (HP:0005978)1.68444680
168Scotoma (HP:0000575)1.67823048
169Breech presentation (HP:0001623)1.67472011
170Dicarboxylic aciduria (HP:0003215)1.67387092
171Abnormality of dicarboxylic acid metabolism (HP:0010995)1.67387092
172Palpitations (HP:0001962)1.67326450
173Horizontal nystagmus (HP:0000666)1.67244074
174Small intestinal stenosis (HP:0012848)1.65961853

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BRD47.58770544
2MAP3K134.42051377
3MUSK3.88291905
4INSRR3.87504398
5MAP4K23.72870230
6PLK43.36482795
7PLK23.04460830
8STK38L2.72852935
9PNCK2.66945685
10DDR22.66127318
11CAMK1G2.54636936
12PDK32.53894804
13PDK42.53894804
14ERBB42.52132818
15MAP3K62.51550519
16NEK92.34703736
17BRAF2.15593685
18EEF2K2.06050623
19BMPR1B1.95310962
20MKNK21.87816111
21CDK91.85899156
22TTK1.85659723
23AKT31.76218785
24CDK81.74120764
25PRKD31.70593680
26PIK3CG1.66179404
27MAPKAPK31.60834845
28WNK41.58608145
29LATS21.58569288
30MAP3K141.52807554
31TAOK11.50344447
32TRIM281.43834954
33MAP3K121.43401024
34TIE11.41083163
35PDK21.40950626
36TAOK31.40520656
37PLK11.40121793
38CAMK1D1.36843725
39WNK11.35591287
40WNK31.33308865
41LATS11.29394304
42NME11.22555467
43NEK61.22133506
44MAP3K31.16730989
45CDK71.09540031
46BRSK21.09522204
47PDK11.08637312
48BCKDK1.01650850
49TXK1.00489915
50PDPK10.96155583
51ADRBK20.93205668
52FRK0.93009269
53NEK20.92851136
54PTK2B0.91183407
55STK390.90203958
56MAP2K70.89691851
57SRPK10.88662877
58TLK10.87293983
59PRKAA20.87093917
60TEC0.84546462
61MOS0.84461928
62MYLK0.84010158
63MKNK10.83695470
64STK240.82090515
65MAPKAPK50.81311219
66OBSCN0.80855135
67CHEK20.80627274
68RPS6KB20.80505123
69VRK10.80395622
70WEE10.79543506
71MST1R0.77881194
72MAP3K110.77419184
73MAPK130.75576289
74CHUK0.74212607
75NME20.73202125
76MAPK110.72542864
77SGK20.72031034
78TRPM70.72030803
79RPS6KA40.71055743
80JAK30.70407273
81RAF10.68818773
82ARAF0.66427453
83IRAK40.65776749
84TNIK0.64960055
85TESK10.64258573
86TYRO30.64057801
87CDC70.62896366
88EIF2AK30.62293529
89MELK0.61722162
90CDK30.61602445
91STK30.60866684
92TYK20.60089172
93KSR20.59139305
94GRK10.57838723
95NLK0.57629858
96DYRK20.57584783
97DYRK30.56287138
98MAP3K50.55276207
99CHEK10.55003352
100OXSR10.54195860
101SIK20.53267993
102PASK0.53029639
103CDK20.52518757
104DYRK1B0.52399422
105CAMK10.51261021
106AURKB0.51258251
107CDK10.51149670
108CDK120.51087670
109STK380.50160995
110STK100.49919598
111PRKG10.49697431
112SIK30.47605177
113FER0.46036976
114IKBKB0.44744172
115GSK3B0.44699711
116MAP3K20.44651687
117IKBKE0.44270785
118MST40.44047145
119PRKCG0.43318518
120EPHA30.41262643
121MAP3K80.39069811
122RPS6KA10.38638543
123MAP2K30.38438728
124MAPK10.38194656
125EIF2AK10.37470478
126STK160.35588803
127MARK20.35475148
128TAF10.34686808
129PRKAA10.34499943
130MAPK150.34362293
131ATR0.33034733
132PLK30.32853019
133ATM0.32547598
134PIM10.31678129
135MAP3K40.31501511
136CCNB10.29917831
137BUB10.29744412
138MAPK80.29660765
139PRKCE0.29628512
140BRSK10.29533824
141KIT0.29401259
142CAMK40.28951599
143MAPK140.27804866
144ACVR1B0.27289600
145RPS6KB10.26534691
146CAMKK20.26038568
147PRKCZ0.25785464
148PRKCQ0.25305821
149PINK10.24407766
150PRKCB0.24154409
151SGK10.23799478
152NUAK10.23718827
153AKT10.23690162
154ZAK0.23506620
155AURKA0.23013668
156BMPR20.22051989
157SGK30.21702561

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002325.51692636
2Basal transcription factors_Homo sapiens_hsa030223.00402753
3Olfactory transduction_Homo sapiens_hsa047402.72095119
4Propanoate metabolism_Homo sapiens_hsa006402.48711527
5RNA polymerase_Homo sapiens_hsa030202.45418119
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.38442048
7Linoleic acid metabolism_Homo sapiens_hsa005912.36750534
8Fatty acid degradation_Homo sapiens_hsa000712.30790384
9RNA degradation_Homo sapiens_hsa030182.28005611
10Vitamin B6 metabolism_Homo sapiens_hsa007502.02943000
11Cell cycle_Homo sapiens_hsa041101.97629824
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.92145273
13Base excision repair_Homo sapiens_hsa034101.90197368
14Homologous recombination_Homo sapiens_hsa034401.86205345
15Pyruvate metabolism_Homo sapiens_hsa006201.79149640
16Primary bile acid biosynthesis_Homo sapiens_hsa001201.74799786
17Pyrimidine metabolism_Homo sapiens_hsa002401.67900699
18Ovarian steroidogenesis_Homo sapiens_hsa049131.66627143
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.65774303
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.63433633
21One carbon pool by folate_Homo sapiens_hsa006701.63387620
22Phototransduction_Homo sapiens_hsa047441.59707461
23Peroxisome_Homo sapiens_hsa041461.59249349
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.58331688
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.58075736
26Type I diabetes mellitus_Homo sapiens_hsa049401.54930623
27Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.53345451
28Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.48470921
29Circadian rhythm_Homo sapiens_hsa047101.45547276
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.40639222
31Fanconi anemia pathway_Homo sapiens_hsa034601.38528582
32Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.37427735
33Taste transduction_Homo sapiens_hsa047421.35629382
34beta-Alanine metabolism_Homo sapiens_hsa004101.32933939
35Chemical carcinogenesis_Homo sapiens_hsa052041.31898629
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.31356287
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.29407448
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.23732779
39Fatty acid metabolism_Homo sapiens_hsa012121.20180205
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.19720112
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.15999909
42Pentose and glucuronate interconversions_Homo sapiens_hsa000401.14987138
43Allograft rejection_Homo sapiens_hsa053301.14150218
44Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.12966483
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.12449891
46Dorso-ventral axis formation_Homo sapiens_hsa043201.12064274
47Sulfur relay system_Homo sapiens_hsa041221.11939827
48Autoimmune thyroid disease_Homo sapiens_hsa053201.11774351
49Purine metabolism_Homo sapiens_hsa002301.11204965
50Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.11029098
51Huntingtons disease_Homo sapiens_hsa050161.09548943
52Ether lipid metabolism_Homo sapiens_hsa005651.07197240
53Arachidonic acid metabolism_Homo sapiens_hsa005901.06692963
54Nitrogen metabolism_Homo sapiens_hsa009101.05716356
55Mismatch repair_Homo sapiens_hsa034301.05419087
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.04428319
57PPAR signaling pathway_Homo sapiens_hsa033201.04017249
58Tryptophan metabolism_Homo sapiens_hsa003800.99282169
59Cyanoamino acid metabolism_Homo sapiens_hsa004600.98458434
60DNA replication_Homo sapiens_hsa030300.97795943
61ABC transporters_Homo sapiens_hsa020100.96382963
62Histidine metabolism_Homo sapiens_hsa003400.96317776
63Intestinal immune network for IgA production_Homo sapiens_hsa046720.96016292
64Graft-versus-host disease_Homo sapiens_hsa053320.95995418
65Folate biosynthesis_Homo sapiens_hsa007900.95935128
66Carbon metabolism_Homo sapiens_hsa012000.94800741
67RNA transport_Homo sapiens_hsa030130.94664742
68Non-homologous end-joining_Homo sapiens_hsa034500.93794283
69Selenocompound metabolism_Homo sapiens_hsa004500.92556637
70Other glycan degradation_Homo sapiens_hsa005110.90878061
71p53 signaling pathway_Homo sapiens_hsa041150.90845732
72Retinol metabolism_Homo sapiens_hsa008300.90224363
73Type II diabetes mellitus_Homo sapiens_hsa049300.87868442
74Herpes simplex infection_Homo sapiens_hsa051680.87627842
75Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.84453766
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.80631313
77Biosynthesis of amino acids_Homo sapiens_hsa012300.80434914
78Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.79588735
79Phenylalanine metabolism_Homo sapiens_hsa003600.79094305
80Antigen processing and presentation_Homo sapiens_hsa046120.76347715
81Nucleotide excision repair_Homo sapiens_hsa034200.72926039
82Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.72086682
83Arginine and proline metabolism_Homo sapiens_hsa003300.70469804
84Fatty acid elongation_Homo sapiens_hsa000620.70077045
85mRNA surveillance pathway_Homo sapiens_hsa030150.69929240
86Tyrosine metabolism_Homo sapiens_hsa003500.69869879
87Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.69211934
88Complement and coagulation cascades_Homo sapiens_hsa046100.69149410
89Cardiac muscle contraction_Homo sapiens_hsa042600.68854481
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.68589819
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65959731
922-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.65715961
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.65432023
94Glucagon signaling pathway_Homo sapiens_hsa049220.63173159
95Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.63042863
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.59710149
97Vitamin digestion and absorption_Homo sapiens_hsa049770.59139457
98Glutathione metabolism_Homo sapiens_hsa004800.59054331
99Protein export_Homo sapiens_hsa030600.58915041
100Starch and sucrose metabolism_Homo sapiens_hsa005000.58064332
101Metabolic pathways_Homo sapiens_hsa011000.57989527
102NF-kappa B signaling pathway_Homo sapiens_hsa040640.57513101
103Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56079259
104Fatty acid biosynthesis_Homo sapiens_hsa000610.55222056
105Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.53059203
106Pancreatic cancer_Homo sapiens_hsa052120.52974426
107Lysine degradation_Homo sapiens_hsa003100.52582154
108Epstein-Barr virus infection_Homo sapiens_hsa051690.51483793
109Parkinsons disease_Homo sapiens_hsa050120.51272047
110Spliceosome_Homo sapiens_hsa030400.49466146
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48362314
112Arginine biosynthesis_Homo sapiens_hsa002200.47949761
113Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47538254
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47523352
115Proteasome_Homo sapiens_hsa030500.47286114
116Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46774488
117Primary immunodeficiency_Homo sapiens_hsa053400.45689923
118Fat digestion and absorption_Homo sapiens_hsa049750.45674846
119Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.45507701
120Measles_Homo sapiens_hsa051620.45274462
121Pentose phosphate pathway_Homo sapiens_hsa000300.45147516
122Oxidative phosphorylation_Homo sapiens_hsa001900.45004375
123Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44926253
124Glycerolipid metabolism_Homo sapiens_hsa005610.44410935
125Inositol phosphate metabolism_Homo sapiens_hsa005620.42849862
126RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.40070313
127Nicotine addiction_Homo sapiens_hsa050330.39869559
128Morphine addiction_Homo sapiens_hsa050320.39187502
129Butanoate metabolism_Homo sapiens_hsa006500.38131001
130Prolactin signaling pathway_Homo sapiens_hsa049170.38120121
131Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38008071
132Asthma_Homo sapiens_hsa053100.37198470
133Galactose metabolism_Homo sapiens_hsa000520.36170009
134Oocyte meiosis_Homo sapiens_hsa041140.35552869
135Calcium signaling pathway_Homo sapiens_hsa040200.35484832
136Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31343946
137Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.31285998
138Influenza A_Homo sapiens_hsa051640.28950503
139Regulation of autophagy_Homo sapiens_hsa041400.27198377
140Steroid biosynthesis_Homo sapiens_hsa001000.27171399
141Serotonergic synapse_Homo sapiens_hsa047260.23561054

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