NRXN3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of proteins that function in the nervous system as receptors and cell adhesion molecules. Extensive alternative splicing and the use of alternative promoters results in multiple transcript variants and protein isoforms for this gene, but the full-length nature of many of these variants has not been determined. Transcripts that initiate from an upstream promoter encode alpha isoforms, which contain epidermal growth factor-like (EGF-like) sequences and laminin G domains. Transcripts initiating from the downstream promoter encode beta isoforms, which lack EGF-like sequences. Genetic variation at this locus has been associated with a range of behavioral phenotypes, including alcohol dependence and autism spectrum disorder. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)5.82081051
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.79716411
3* vocalization behavior (GO:0071625)5.43427623
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.32774227
5protein localization to synapse (GO:0035418)5.27222180
6* neuron cell-cell adhesion (GO:0007158)5.17709460
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.08722965
8ionotropic glutamate receptor signaling pathway (GO:0035235)4.88604842
9regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.78412030
10regulation of glutamate receptor signaling pathway (GO:1900449)4.76801247
11glutamate secretion (GO:0014047)4.68661813
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.68322042
13glutamate receptor signaling pathway (GO:0007215)4.61985336
14regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.56965469
15regulation of synaptic vesicle exocytosis (GO:2000300)4.54119410
16locomotory exploration behavior (GO:0035641)4.50723306
17neuronal action potential propagation (GO:0019227)4.49162565
18* neurotransmitter secretion (GO:0007269)4.41829812
19neuron-neuron synaptic transmission (GO:0007270)4.39746519
20gamma-aminobutyric acid signaling pathway (GO:0007214)4.32198263
21synaptic transmission, glutamatergic (GO:0035249)4.25399059
22gamma-aminobutyric acid transport (GO:0015812)4.22103845
23pyrimidine nucleobase catabolic process (GO:0006208)4.18669835
24negative regulation of synaptic transmission, GABAergic (GO:0032229)4.17331254
25exploration behavior (GO:0035640)4.10047516
26synaptic vesicle maturation (GO:0016188)4.07986700
27regulation of long-term neuronal synaptic plasticity (GO:0048169)4.07118163
28neuron recognition (GO:0008038)4.06943809
29neurotransmitter-gated ion channel clustering (GO:0072578)4.05794010
30regulation of synaptic vesicle transport (GO:1902803)4.04817235
31startle response (GO:0001964)4.02277604
32presynaptic membrane assembly (GO:0097105)4.01170379
33regulation of excitatory postsynaptic membrane potential (GO:0060079)3.88798331
34G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.83281656
35regulation of neuronal synaptic plasticity (GO:0048168)3.77618408
36* neurotransmitter transport (GO:0006836)3.77213129
37regulation of postsynaptic membrane potential (GO:0060078)3.77079501
38negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.76705544
39long-term memory (GO:0007616)3.76339610
40presynaptic membrane organization (GO:0097090)3.74186760
41response to histamine (GO:0034776)3.70708331
42membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.70581377
43positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.69166605
44regulation of synaptic transmission, glutamatergic (GO:0051966)3.69036773
45neuronal ion channel clustering (GO:0045161)3.66526810
46sodium ion export (GO:0071436)3.66036544
47positive regulation of membrane potential (GO:0045838)3.65439806
48transmission of nerve impulse (GO:0019226)3.65062675
49behavioral response to cocaine (GO:0048148)3.64157023
50long-term synaptic potentiation (GO:0060291)3.63226776
51mating behavior (GO:0007617)3.61461074
52synaptic vesicle endocytosis (GO:0048488)3.59246401
53postsynaptic membrane organization (GO:0001941)3.58814819
54regulation of synapse structural plasticity (GO:0051823)3.57239070
55regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.55423048
56synaptic vesicle docking involved in exocytosis (GO:0016081)3.53920884
57membrane hyperpolarization (GO:0060081)3.53446617
58nucleobase catabolic process (GO:0046113)3.52774771
59cellular potassium ion homeostasis (GO:0030007)3.48807327
60layer formation in cerebral cortex (GO:0021819)3.48628321
61cerebellar Purkinje cell differentiation (GO:0021702)3.47752490
62* regulation of neurotransmitter levels (GO:0001505)3.46847472
63striatum development (GO:0021756)3.45947991
64cerebellar granule cell differentiation (GO:0021707)3.44032959
65prepulse inhibition (GO:0060134)3.43634849
66positive regulation of dendritic spine development (GO:0060999)3.41733856
67regulation of vesicle fusion (GO:0031338)3.39198098
68axonal fasciculation (GO:0007413)3.38432092
69neuromuscular synaptic transmission (GO:0007274)3.35798846
70amino acid import (GO:0043090)3.35712575
71* synapse assembly (GO:0007416)3.34309650
72central nervous system myelination (GO:0022010)3.34145229
73axon ensheathment in central nervous system (GO:0032291)3.34145229
74establishment of mitochondrion localization (GO:0051654)3.33710295
75L-amino acid import (GO:0043092)3.33459586
76membrane depolarization (GO:0051899)3.32033218
77glycosphingolipid biosynthetic process (GO:0006688)3.31691478
78positive regulation of dendritic spine morphogenesis (GO:0061003)3.31371497
79synaptic transmission, dopaminergic (GO:0001963)3.30856140
80regulation of neurotransmitter secretion (GO:0046928)3.24893958
81regulation of synaptic plasticity (GO:0048167)3.23833064
82dendritic spine morphogenesis (GO:0060997)3.23442850
83cell migration in hindbrain (GO:0021535)3.21308636
84response to cocaine (GO:0042220)3.20464757
85regulation of voltage-gated calcium channel activity (GO:1901385)3.17890154
86detection of calcium ion (GO:0005513)3.17703802
87regulation of glutamate secretion (GO:0014048)3.16007351
88regulation of dendritic spine development (GO:0060998)3.15873755
89membrane depolarization during action potential (GO:0086010)3.15720243
90synaptic vesicle transport (GO:0048489)3.14142882
91establishment of synaptic vesicle localization (GO:0097480)3.14142882
92synaptic transmission (GO:0007268)3.13752823
93dendrite morphogenesis (GO:0048813)3.12997550
94* learning (GO:0007612)3.12712034
95* positive regulation of synapse assembly (GO:0051965)3.11984675
96serotonin metabolic process (GO:0042428)3.10504596
97regulation of synaptic transmission, GABAergic (GO:0032228)3.09800493
98behavioral fear response (GO:0001662)3.09684926
99behavioral defense response (GO:0002209)3.09684926
100C4-dicarboxylate transport (GO:0015740)3.09019385
101mechanosensory behavior (GO:0007638)3.07993245
102regulation of neurotransmitter transport (GO:0051588)3.06956428
103negative regulation of neurotransmitter transport (GO:0051589)3.05957308
104* positive regulation of synapse maturation (GO:0090129)3.05554789
105innervation (GO:0060384)3.04473475
106regulation of dendritic spine morphogenesis (GO:0061001)3.03591320
107positive regulation of synaptic transmission, GABAergic (GO:0032230)3.01011483
108potassium ion import (GO:0010107)3.00536523
109regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.00215920
110auditory behavior (GO:0031223)2.98753338
111proline transport (GO:0015824)2.98419276
112* synapse organization (GO:0050808)2.94444059
113fear response (GO:0042596)2.94189737
114positive regulation of neurotransmitter transport (GO:0051590)2.93817823
115positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.93482538
116positive regulation of synaptic transmission (GO:0050806)2.92970982
117acidic amino acid transport (GO:0015800)2.90623787
118cellular sodium ion homeostasis (GO:0006883)2.89251784
119cell differentiation in hindbrain (GO:0021533)2.88592842
120regulation of synaptic transmission (GO:0050804)2.88420072
121response to auditory stimulus (GO:0010996)2.86863059
122dopamine transport (GO:0015872)2.85587735
123primary amino compound metabolic process (GO:1901160)2.84936208
124adult walking behavior (GO:0007628)2.84420432
125positive regulation of potassium ion transmembrane transport (GO:1901381)2.84376356
126cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.83528425
127potassium ion homeostasis (GO:0055075)2.83181525
128positive regulation of neurotransmitter secretion (GO:0001956)2.82632105

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.19938877
2GBX2_23144817_ChIP-Seq_PC3_Human4.23342600
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.11491505
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.02122871
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.99892250
6TAF15_26573619_Chip-Seq_HEK293_Human2.70905248
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.57178478
8* REST_21632747_ChIP-Seq_MESCs_Mouse2.54731955
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.51517951
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.50306371
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.50306371
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.48247545
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.46399259
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.44339089
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.39484097
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.34609566
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.30697594
18CTBP2_25329375_ChIP-Seq_LNCAP_Human2.30147537
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.29560464
20* CTBP1_25329375_ChIP-Seq_LNCAP_Human2.14349262
21ZFP57_27257070_Chip-Seq_ESCs_Mouse2.12748706
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.11830364
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.09998508
24EZH2_27294783_Chip-Seq_ESCs_Mouse2.08691540
25DROSHA_22980978_ChIP-Seq_HELA_Human2.08400795
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.05261634
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.04257119
28* REST_18959480_ChIP-ChIP_MESCs_Mouse2.01310123
29RARB_27405468_Chip-Seq_BRAIN_Mouse2.00904515
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.95154625
31AR_21572438_ChIP-Seq_LNCaP_Human1.92660692
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.90959748
33IKZF1_21737484_ChIP-ChIP_HCT116_Human1.87496820
34IGF1R_20145208_ChIP-Seq_DFB_Human1.85680254
35* SMAD4_21799915_ChIP-Seq_A2780_Human1.83889724
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83424677
37P300_19829295_ChIP-Seq_ESCs_Human1.79971523
38* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.79728432
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.78375841
40BMI1_23680149_ChIP-Seq_NPCS_Mouse1.74803754
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.68895603
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65596484
43FUS_26573619_Chip-Seq_HEK293_Human1.59403505
44ZNF274_21170338_ChIP-Seq_K562_Hela1.54545108
45* PIAS1_25552417_ChIP-Seq_VCAP_Human1.53225447
46PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.52325824
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.49899927
48* SMAD3_21741376_ChIP-Seq_EPCs_Human1.49398986
49* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43589961
50VDR_22108803_ChIP-Seq_LS180_Human1.42422814
51RNF2_27304074_Chip-Seq_NSC_Mouse1.42068014
52RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.41699391
53AR_25329375_ChIP-Seq_VCAP_Human1.41351685
54* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40660479
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40171508
56* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36375566
57* SOX2_21211035_ChIP-Seq_LN229_Gbm1.35550067
58RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.34774271
59* STAT3_23295773_ChIP-Seq_U87_Human1.29137196
60TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.27293310
61NR3C1_23031785_ChIP-Seq_PC12_Mouse1.25549636
62* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25543703
63ERG_21242973_ChIP-ChIP_JURKAT_Human1.21905481
64* ER_23166858_ChIP-Seq_MCF-7_Human1.21192088
65* TCF4_23295773_ChIP-Seq_U87_Human1.18943818
66RING1B_27294783_Chip-Seq_ESCs_Mouse1.16463986
67* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15962710
68AR_19668381_ChIP-Seq_PC3_Human1.15344643
69MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.13823364
70CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13771430
71P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12742504
72ARNT_22903824_ChIP-Seq_MCF-7_Human1.12480386
73* RUNX2_22187159_ChIP-Seq_PCA_Human1.12466245
74NANOG_18555785_Chip-Seq_ESCs_Mouse1.10846554
75TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09465242
76CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08851458
77MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07636906
78EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07301973
79AHR_22903824_ChIP-Seq_MCF-7_Human1.07231690
80PRDM14_20953172_ChIP-Seq_ESCs_Human1.05823747
81* BCAT_22108803_ChIP-Seq_LS180_Human1.05437887
82JUN_21703547_ChIP-Seq_K562_Human1.05322796
83TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04789137
84POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04789137
85CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.04616170
86MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03604680
87* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02804918
88* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01020469
89* CBP_20019798_ChIP-Seq_JUKART_Human1.01020469
90* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99715397
91ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99593791
92TP53_18474530_ChIP-ChIP_U2OS_Human0.99486795
93* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98882469
94TP53_16413492_ChIP-PET_HCT116_Human0.97860332
95FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.97832108
96RING1B_27294783_Chip-Seq_NPCs_Mouse0.97212792
97* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96293741
98PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95634048
99* KDM2B_26808549_Chip-Seq_REH_Human0.94894511
100BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.94312835
101MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93542552
102EWS_26573619_Chip-Seq_HEK293_Human0.93375436
103* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93119187
104* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.92861024
105SMAD3_21741376_ChIP-Seq_ESCs_Human0.91474656
106* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91166514
107* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91082413
108CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.90936249
109EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90451410
110HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.88909672
111KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.88882199
112STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.87870137
113GATA1_26923725_Chip-Seq_HPCs_Mouse0.87707164
114* FLI1_21867929_ChIP-Seq_TH2_Mouse0.86422934

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.08433333
2MP0003880_abnormal_central_pattern5.05371159
3MP0003635_abnormal_synaptic_transmissio3.98133395
4MP0009046_muscle_twitch3.57446865
5MP0009745_abnormal_behavioral_response3.45031328
6MP0002822_catalepsy3.36061552
7MP0002064_seizures3.26693188
8MP0002063_abnormal_learning/memory/cond3.16187807
9MP0004270_analgesia2.93857394
10MP0002572_abnormal_emotion/affect_behav2.90643628
11MP0001968_abnormal_touch/_nociception2.87137818
12MP0002272_abnormal_nervous_system2.69162441
13MP0005423_abnormal_somatic_nervous2.68660295
14MP0001486_abnormal_startle_reflex2.60449471
15MP0002735_abnormal_chemical_nociception2.57678392
16MP0001501_abnormal_sleep_pattern2.52795708
17MP0002734_abnormal_mechanical_nocicepti2.44368930
18MP0002736_abnormal_nociception_after2.40256782
19MP0006276_abnormal_autonomic_nervous2.27805876
20MP0002067_abnormal_sensory_capabilities2.17326947
21MP0001529_abnormal_vocalization2.15062859
22MP0001440_abnormal_grooming_behavior2.12765093
23MP0001188_hyperpigmentation2.11408538
24MP0002184_abnormal_innervation2.04470111
25MP0001984_abnormal_olfaction1.97728228
26MP0002733_abnormal_thermal_nociception1.93576479
27MP0002557_abnormal_social/conspecific_i1.90002270
28MP0001970_abnormal_pain_threshold1.84961123
29MP0004924_abnormal_behavior1.84847636
30MP0005386_behavior/neurological_phenoty1.84847636
31MP0000778_abnormal_nervous_system1.78138169
32MP0001905_abnormal_dopamine_level1.74428764
33MP0008569_lethality_at_weaning1.71410920
34MP0005551_abnormal_eye_electrophysiolog1.69672890
35MP0005646_abnormal_pituitary_gland1.68577915
36MP0004142_abnormal_muscle_tone1.54821185
37MP0002102_abnormal_ear_morphology1.53637061
38MP0001502_abnormal_circadian_rhythm1.49303592
39MP0002909_abnormal_adrenal_gland1.48166750
40MP0004811_abnormal_neuron_physiology1.47970304
41MP0001986_abnormal_taste_sensitivity1.46431933
42MP0003879_abnormal_hair_cell1.45220372
43MP0002837_dystrophic_cardiac_calcinosis1.44224508
44MP0003122_maternal_imprinting1.42404170
45MP0002066_abnormal_motor_capabilities/c1.40943080
46MP0002882_abnormal_neuron_morphology1.40890139
47MP0010386_abnormal_urinary_bladder1.40474821
48MP0003329_amyloid_beta_deposits1.39579466
49MP0000955_abnormal_spinal_cord1.38455912
50MP0003787_abnormal_imprinting1.37804917
51MP0009780_abnormal_chondrocyte_physiolo1.29911830
52MP0004742_abnormal_vestibular_system1.26835576
53MP0008877_abnormal_DNA_methylation1.25827997
54MP0005645_abnormal_hypothalamus_physiol1.19357543
55MP0004858_abnormal_nervous_system1.17696167
56MP0004147_increased_porphyrin_level1.17430406
57MP0002638_abnormal_pupillary_reflex1.08931272
58MP0008872_abnormal_physiological_respon1.08093140
59MP0002152_abnormal_brain_morphology1.07757362
60MP0005499_abnormal_olfactory_system1.07637609
61MP0005394_taste/olfaction_phenotype1.07637609
62MP0002229_neurodegeneration1.03280658
63MP0002090_abnormal_vision0.98506307
64MP0006072_abnormal_retinal_apoptosis0.98453346
65MP0004145_abnormal_muscle_electrophysio0.96279837
66MP0003633_abnormal_nervous_system0.96254253
67MP0004215_abnormal_myocardial_fiber0.95988750
68MP0002069_abnormal_eating/drinking_beha0.95777130
69MP0002752_abnormal_somatic_nervous0.95691373
70MP0004885_abnormal_endolymph0.95244453
71MP0000631_abnormal_neuroendocrine_gland0.94408764
72MP0005409_darkened_coat_color0.93623863
73MP0003631_nervous_system_phenotype0.93619374
74MP0001963_abnormal_hearing_physiology0.91360310
75MP0004085_abnormal_heartbeat0.90479326
76MP0000751_myopathy0.88318828
77MP0003938_abnormal_ear_development0.86420448
78MP0006292_abnormal_olfactory_placode0.86251774
79MP0002876_abnormal_thyroid_physiology0.85790343
80MP0001177_atelectasis0.83716511
81MP0005535_abnormal_body_temperature0.82068503
82MP0004043_abnormal_pH_regulation0.80497209
83MP0003632_abnormal_nervous_system0.79999299
84MP0000013_abnormal_adipose_tissue0.79539828
85MP0000569_abnormal_digit_pigmentation0.79000182
86MP0000049_abnormal_middle_ear0.76495241
87MP0002653_abnormal_ependyma_morphology0.76408011
88MP0005253_abnormal_eye_physiology0.74862311
89MP0005187_abnormal_penis_morphology0.73815369
90MP0004133_heterotaxia0.72784030
91MP0008874_decreased_physiological_sensi0.72275582
92MP0001664_abnormal_digestion0.71252900
93MP0003690_abnormal_glial_cell0.70658743
94MP0003137_abnormal_impulse_conducting0.69891449
95MP0001299_abnormal_eye_distance/0.68376449
96MP0003119_abnormal_digestive_system0.67854852
97MP0002234_abnormal_pharynx_morphology0.66275215
98MP0003634_abnormal_glial_cell0.65555490
99MP0000026_abnormal_inner_ear0.64563138
100MP0002249_abnormal_larynx_morphology0.64041856
101MP0003878_abnormal_ear_physiology0.63190812
102MP0005377_hearing/vestibular/ear_phenot0.63190812
103MP0001270_distended_abdomen0.62370169
104MP0002332_abnormal_exercise_endurance0.61813038
105MP0004484_altered_response_of0.61762373
106MP0004233_abnormal_muscle_weight0.61443412
107MP0001943_abnormal_respiration0.61059052
108MP0005195_abnormal_posterior_eye0.59787436
109MP0002751_abnormal_autonomic_nervous0.58347520
110MP0003121_genomic_imprinting0.57531239
111MP0003861_abnormal_nervous_system0.57067424
112MP0008789_abnormal_olfactory_epithelium0.56901395
113* MP0002082_postnatal_lethality0.55616359
114* MP0010770_preweaning_lethality0.55616359
115MP0005171_absent_coat_pigmentation0.53726501
116* MP0010769_abnormal_survival0.53686485
117MP0001485_abnormal_pinna_reflex0.52297096
118* MP0010768_mortality/aging0.50889461
119MP0000920_abnormal_myelination0.50381917

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.20618096
2Focal seizures (HP:0007359)5.71739508
3Epileptic encephalopathy (HP:0200134)5.35564016
4Febrile seizures (HP:0002373)5.32986490
5Atonic seizures (HP:0010819)5.17467542
6Visual hallucinations (HP:0002367)5.00958954
7Myokymia (HP:0002411)4.93432506
8Hyperventilation (HP:0002883)4.80405134
9Progressive cerebellar ataxia (HP:0002073)4.67235617
10Absence seizures (HP:0002121)4.56430124
11Dialeptic seizures (HP:0011146)4.25921576
12Generalized tonic-clonic seizures (HP:0002069)3.87341106
13Limb dystonia (HP:0002451)3.85931989
14Broad-based gait (HP:0002136)3.75618009
15Gaze-evoked nystagmus (HP:0000640)3.42633920
16Progressive inability to walk (HP:0002505)3.33629044
17Truncal ataxia (HP:0002078)3.02958998
18Amblyopia (HP:0000646)3.00555812
19Impaired social interactions (HP:0000735)2.98300641
20Abnormal social behavior (HP:0012433)2.98300641
21Action tremor (HP:0002345)2.97362567
22Dysdiadochokinesis (HP:0002075)2.97058850
23Poor eye contact (HP:0000817)2.96381829
24Urinary urgency (HP:0000012)2.90819765
25Excessive salivation (HP:0003781)2.87504496
26Drooling (HP:0002307)2.87504496
27Absent speech (HP:0001344)2.87391401
28Pheochromocytoma (HP:0002666)2.81488147
29Abnormality of the corticospinal tract (HP:0002492)2.75122861
30Inability to walk (HP:0002540)2.72870364
31Epileptiform EEG discharges (HP:0011182)2.69498079
32Protruding tongue (HP:0010808)2.66015055
33Anxiety (HP:0000739)2.63905539
34Neuroendocrine neoplasm (HP:0100634)2.61003020
35Gait imbalance (HP:0002141)2.59084837
36Amyotrophic lateral sclerosis (HP:0007354)2.57548325
37EEG with generalized epileptiform discharges (HP:0011198)2.56830730
38Dysmetria (HP:0001310)2.56760155
39Depression (HP:0000716)2.56012310
40Cerebral hypomyelination (HP:0006808)2.54002197
41Hemiparesis (HP:0001269)2.52333509
42Congenital stationary night blindness (HP:0007642)2.47092801
43Intention tremor (HP:0002080)2.46911764
44Abnormal eating behavior (HP:0100738)2.45758555
45Spastic tetraplegia (HP:0002510)2.41450020
46Status epilepticus (HP:0002133)2.40498683
47Mutism (HP:0002300)2.40046694
48Scanning speech (HP:0002168)2.39991351
49Polyphagia (HP:0002591)2.39333743
50Abnormality of the lower motor neuron (HP:0002366)2.39199002
51Split foot (HP:0001839)2.38994974
52Abnormality of binocular vision (HP:0011514)2.35250451
53Diplopia (HP:0000651)2.35250451
54Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.34889814
55Degeneration of the lateral corticospinal tracts (HP:0002314)2.34889814
56Supranuclear gaze palsy (HP:0000605)2.33739909
57Genetic anticipation (HP:0003743)2.32632480
58Hypsarrhythmia (HP:0002521)2.31489833
59Congenital primary aphakia (HP:0007707)2.30421516
60Fetal akinesia sequence (HP:0001989)2.29564182
61Central scotoma (HP:0000603)2.29061575
62Morphological abnormality of the pyramidal tract (HP:0002062)2.28549058
63Abnormality of macular pigmentation (HP:0008002)2.28391942
64Impaired vibration sensation in the lower limbs (HP:0002166)2.28357334
65Impaired smooth pursuit (HP:0007772)2.25191656
66Cerebral inclusion bodies (HP:0100314)2.23947330
67Abnormal hair whorl (HP:0010721)2.22648765
68Genital tract atresia (HP:0001827)2.22414455
69Medial flaring of the eyebrow (HP:0010747)2.22114183
70Torticollis (HP:0000473)2.21861518
71Vaginal atresia (HP:0000148)2.20128251
72Bradykinesia (HP:0002067)2.19329506
73Generalized myoclonic seizures (HP:0002123)2.17730084
74Urinary bladder sphincter dysfunction (HP:0002839)2.17136287
75Nephrogenic diabetes insipidus (HP:0009806)2.16180507
76Lower limb muscle weakness (HP:0007340)2.14949197
77Abnormality of ocular smooth pursuit (HP:0000617)2.12841807
78Type II lissencephaly (HP:0007260)2.12619814
79Failure to thrive in infancy (HP:0001531)2.11972584
80Postural instability (HP:0002172)2.11285945
81Blue irides (HP:0000635)2.10814778
82Ankle clonus (HP:0011448)2.10665337
83Esotropia (HP:0000565)2.10548510
84Thickened helices (HP:0000391)2.09369608
85Akinesia (HP:0002304)2.08835904
86Sleep apnea (HP:0010535)2.06690240
87Acute necrotizing encephalopathy (HP:0006965)2.06307955
88Abnormality of the labia minora (HP:0012880)2.04851402
89Peripheral hypomyelination (HP:0007182)2.03346514
90Specific learning disability (HP:0001328)2.02315110
91Pachygyria (HP:0001302)2.01525875
92Retinal dysplasia (HP:0007973)2.01453903
93Stereotypic behavior (HP:0000733)2.00829671
94Clonus (HP:0002169)1.99756186
95Gastroesophageal reflux (HP:0002020)1.98521043
96Papilledema (HP:0001085)1.96817053
97Progressive macrocephaly (HP:0004481)1.96227396
98Gait ataxia (HP:0002066)1.94584135
99Hypoplasia of the corpus callosum (HP:0002079)1.94307341
100Neurofibrillary tangles (HP:0002185)1.94095976
101Abnormality of salivation (HP:0100755)1.92205203
102Dyskinesia (HP:0100660)1.90279524
103Spastic tetraparesis (HP:0001285)1.89958401
104Hemiplegia (HP:0002301)1.89880234
105Exotropia (HP:0000577)1.89005724
106Abnormal mitochondria in muscle tissue (HP:0008316)1.87621478
107Hyperthyroidism (HP:0000836)1.87179821
108Fair hair (HP:0002286)1.85688893
109Widely spaced teeth (HP:0000687)1.84829316
110Spastic gait (HP:0002064)1.84736312
111Horizontal nystagmus (HP:0000666)1.83489235
112CNS hypomyelination (HP:0003429)1.83237534
113Psychosis (HP:0000709)1.81207483
114Intellectual disability, severe (HP:0010864)1.80555645
115Incomplete penetrance (HP:0003829)1.80253200
116Agitation (HP:0000713)1.80217959
117Dysmetric saccades (HP:0000641)1.79889859
118Hypoventilation (HP:0002791)1.79550763
119Focal dystonia (HP:0004373)1.78926417
120Generalized hypopigmentation of hair (HP:0011358)1.77988065
121Optic disc pallor (HP:0000543)1.77152477
122Alacrima (HP:0000522)1.76630781
123Hypoplasia of the brainstem (HP:0002365)1.75693137
124Aplasia/Hypoplasia of the brainstem (HP:0007362)1.75693137
125Lissencephaly (HP:0001339)1.74973306
126Poor coordination (HP:0002370)1.73962667
127Dynein arm defect of respiratory motile cilia (HP:0012255)1.72682657
128Absent/shortened dynein arms (HP:0200106)1.72682657
129Delusions (HP:0000746)1.72465197
130Choreoathetosis (HP:0001266)1.69973430
131Muscular hypotonia of the trunk (HP:0008936)1.68807576
132Optic nerve hypoplasia (HP:0000609)1.67112666

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.19337602
2EPHA43.76836795
3CASK3.66757915
4MAP3K43.56198831
5MAP2K73.32329168
6MAP3K123.00351140
7MAP3K92.79896582
8MARK12.71976408
9PNCK2.68721756
10MINK12.30283200
11MAP2K42.25260689
12NTRK22.07528720
13RIPK41.98178804
14TNIK1.77423239
15PLK21.71440687
16DAPK21.70740552
17GRK51.64741595
18PAK61.61123388
19TRIM281.61075607
20FRK1.58979024
21AKT31.52432816
22MAPK131.52019345
23PRPF4B1.50525805
24NTRK11.48463327
25SIK21.46823055
26CDK51.38575902
27DAPK11.35323317
28MAP4K21.32791711
29KSR11.32253746
30FES1.30672103
31PRKCG1.24637189
32CAMK2A1.23941961
33DYRK21.17576707
34CAMKK21.13480962
35NME11.11918878
36CDK191.10820486
37SGK21.10237573
38SGK2231.09985393
39SGK4941.09985393
40CAMK2B1.03713926
41ARAF1.03259818
42BMPR21.03032581
43CAMKK11.01223876
44KSR21.00931414
45CSNK1A1L0.98285308
46DYRK1A0.97671184
47PTK2B0.95035037
48CSNK1G20.93543225
49UHMK10.92679551
50STK380.90456678
51CSNK1G10.89202281
52OXSR10.88469476
53BMPR1B0.85929700
54MAP3K130.83922897
55CDK180.80153206
56CAMK2D0.78556093
57CDK140.78020781
58CCNB10.76843485
59CDK150.76456833
60FGR0.76169559
61CAMK10.76009441
62ERBB40.75215173
63CAMK40.74972178
64MAP3K60.74485140
65SGK10.73909792
66PHKG10.73856626
67PHKG20.73856626
68PRKCE0.72643948
69SGK30.70212370
70LIMK10.68658982
71CAMK1G0.67201229
72STK110.66896493
73PINK10.65853939
74CDK11A0.65502566
75SIK30.64984941
76TNK20.63757330
77BRAF0.62787106
78MUSK0.62712895
79STK38L0.61187938
80MAPKAPK50.58928695
81GRK70.58268402
82CSNK1G30.57434901
83ADRBK20.57021123
84ROCK20.55915090
85PRKCH0.55675525
86CAMK2G0.55106088
87TYRO30.54097414
88PRKD30.54036409
89WNK30.53329493
90GRK10.53174520
91WNK10.52846514
92FGFR20.52680028
93EPHA30.52502264
94PAK30.52436320
95LATS20.49932831
96BCR0.49896784
97PKN10.49318544
98CSNK1D0.49003835
99RET0.48722347
100STK390.47708177
101FER0.47562777
102PRKACA0.46697840
103ADRBK10.45586185
104PRKCZ0.45440702
105CSNK1A10.44970030
106RPS6KA30.44352138
107MAPK100.44041807
108MARK20.43972229
109ACVR1B0.43926530
110ERBB30.42153892
111CDK30.41416979
112GRK60.39660762
113PRKCB0.39631974
114YES10.39252829
115PRKG10.37556916
116NEK60.37471270
117TSSK60.37421916
118INSRR0.36889166
119RAF10.36791267
120CSNK1E0.34961466
121PRKCA0.34418861
122MAPK120.31455536
123PRKACB0.30723864
124PRKAA10.27575454
125WNK40.26259016
126RPS6KB10.23529720

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.61627828
2Synaptic vesicle cycle_Homo sapiens_hsa047213.69617862
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.11658540
4GABAergic synapse_Homo sapiens_hsa047273.08994685
5Morphine addiction_Homo sapiens_hsa050322.72143019
6Circadian entrainment_Homo sapiens_hsa047132.59712305
7Glutamatergic synapse_Homo sapiens_hsa047242.58856268
8Amphetamine addiction_Homo sapiens_hsa050312.46929791
9Long-term potentiation_Homo sapiens_hsa047202.45641268
10Collecting duct acid secretion_Homo sapiens_hsa049662.36807593
11Olfactory transduction_Homo sapiens_hsa047402.33609247
12Dopaminergic synapse_Homo sapiens_hsa047282.25000811
13Serotonergic synapse_Homo sapiens_hsa047262.16794135
14Taste transduction_Homo sapiens_hsa047422.15025456
15Salivary secretion_Homo sapiens_hsa049702.07977210
16Long-term depression_Homo sapiens_hsa047301.88519802
17Insulin secretion_Homo sapiens_hsa049111.88022774
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.86978069
19Cholinergic synapse_Homo sapiens_hsa047251.85863254
20Cocaine addiction_Homo sapiens_hsa050301.79604254
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.75704235
22Calcium signaling pathway_Homo sapiens_hsa040201.67553427
23Renin secretion_Homo sapiens_hsa049241.65604113
24Oxidative phosphorylation_Homo sapiens_hsa001901.64544719
25Gastric acid secretion_Homo sapiens_hsa049711.56727397
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.54083634
27Oxytocin signaling pathway_Homo sapiens_hsa049211.53045176
28Cardiac muscle contraction_Homo sapiens_hsa042601.52569972
29Phototransduction_Homo sapiens_hsa047441.52063135
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.51202391
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.41698740
32Vibrio cholerae infection_Homo sapiens_hsa051101.39665950
33Alzheimers disease_Homo sapiens_hsa050101.26190020
34Parkinsons disease_Homo sapiens_hsa050121.22605911
35Gap junction_Homo sapiens_hsa045401.20097535
36GnRH signaling pathway_Homo sapiens_hsa049121.19813918
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.16862500
38cAMP signaling pathway_Homo sapiens_hsa040241.08320471
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08085445
40Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.05967625
41Axon guidance_Homo sapiens_hsa043601.05932381
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03768685
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.02763092
44Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.00916102
45Phosphatidylinositol signaling system_Homo sapiens_hsa040700.92220660
46Type II diabetes mellitus_Homo sapiens_hsa049300.89675285
47Estrogen signaling pathway_Homo sapiens_hsa049150.89323004
48cGMP-PKG signaling pathway_Homo sapiens_hsa040220.88815515
49Nitrogen metabolism_Homo sapiens_hsa009100.86495444
50ErbB signaling pathway_Homo sapiens_hsa040120.86357006
51Melanogenesis_Homo sapiens_hsa049160.84211297
52Vascular smooth muscle contraction_Homo sapiens_hsa042700.83062986
53Type I diabetes mellitus_Homo sapiens_hsa049400.81943373
54Huntingtons disease_Homo sapiens_hsa050160.78911873
55Pancreatic secretion_Homo sapiens_hsa049720.75883261
56Glioma_Homo sapiens_hsa052140.72592035
57Dilated cardiomyopathy_Homo sapiens_hsa054140.69308717
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68116624
59beta-Alanine metabolism_Homo sapiens_hsa004100.64723361
60Alcoholism_Homo sapiens_hsa050340.63975070
61MAPK signaling pathway_Homo sapiens_hsa040100.62964201
62Oocyte meiosis_Homo sapiens_hsa041140.61876007
63Thyroid hormone synthesis_Homo sapiens_hsa049180.60911223
64Rheumatoid arthritis_Homo sapiens_hsa053230.58178647
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58026409
66* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57568235
67Ether lipid metabolism_Homo sapiens_hsa005650.55433620
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.55310908
69Butanoate metabolism_Homo sapiens_hsa006500.54969887
70Circadian rhythm_Homo sapiens_hsa047100.54935637
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53834608
72Choline metabolism in cancer_Homo sapiens_hsa052310.53380301
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53328850
74Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51687551
75Dorso-ventral axis formation_Homo sapiens_hsa043200.49848305
76Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47186498
77African trypanosomiasis_Homo sapiens_hsa051430.47095880
78Ras signaling pathway_Homo sapiens_hsa040140.45428351
79Linoleic acid metabolism_Homo sapiens_hsa005910.44414261
80Inositol phosphate metabolism_Homo sapiens_hsa005620.44166957
81Glucagon signaling pathway_Homo sapiens_hsa049220.42899429
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42869888
83Vitamin B6 metabolism_Homo sapiens_hsa007500.42039999
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40264729
85Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.39233162
86Wnt signaling pathway_Homo sapiens_hsa043100.39132295
87Rap1 signaling pathway_Homo sapiens_hsa040150.38603047
88Hippo signaling pathway_Homo sapiens_hsa043900.37768138
89Fatty acid biosynthesis_Homo sapiens_hsa000610.37492881
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36894616
91Regulation of autophagy_Homo sapiens_hsa041400.35195008
92Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.33866424
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.32143214
94ABC transporters_Homo sapiens_hsa020100.31085554
95Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30607945
96Phagosome_Homo sapiens_hsa041450.29705342
97Histidine metabolism_Homo sapiens_hsa003400.29625621
98Ovarian steroidogenesis_Homo sapiens_hsa049130.27366378
99Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.27350498
100Arginine and proline metabolism_Homo sapiens_hsa003300.26689458
101Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26392854
102Hedgehog signaling pathway_Homo sapiens_hsa043400.26209840
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.25034493
104Renal cell carcinoma_Homo sapiens_hsa052110.25026973
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.24116021
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24102608
107VEGF signaling pathway_Homo sapiens_hsa043700.23271230
108Tight junction_Homo sapiens_hsa045300.21229072
109Bile secretion_Homo sapiens_hsa049760.20700010
110Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.20336596
111Arginine biosynthesis_Homo sapiens_hsa002200.19420934
112Mineral absorption_Homo sapiens_hsa049780.19054863
113Melanoma_Homo sapiens_hsa052180.19043075
114mTOR signaling pathway_Homo sapiens_hsa041500.18432169
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.17539116
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.16820980
117Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.16086515

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