NRP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.57849229
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.57849229
3positive regulation by organism of defense response of other organism involved in symbiotic interact6.57849229
4modulation by symbiont of host immune response (GO:0052553)6.57849229
5positive regulation by symbiont of host defense response (GO:0052509)6.57849229
6modulation by symbiont of host defense response (GO:0052031)6.57849229
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.78933963
8macrophage activation involved in immune response (GO:0002281)4.66012662
9retina vasculature morphogenesis in camera-type eye (GO:0061299)4.41623102
10regulation of interferon-beta biosynthetic process (GO:0045357)4.34320757
11response to host immune response (GO:0052572)4.33664373
12response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.33664373
13cell adhesion mediated by integrin (GO:0033627)4.31769360
14positive regulation of interferon-alpha production (GO:0032727)4.29005814
15regulation of interferon-alpha production (GO:0032647)4.06030153
16response to peptidoglycan (GO:0032494)4.04288047
17response to host (GO:0075136)3.95854386
18response to host defenses (GO:0052200)3.95854386
19response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.95854386
20neutrophil activation involved in immune response (GO:0002283)3.93311406
21I-kappaB phosphorylation (GO:0007252)3.80127238
22glial cell migration (GO:0008347)3.79235482
23virion attachment to host cell (GO:0019062)3.76585890
24adhesion of symbiont to host cell (GO:0044650)3.76585890
25positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.71239559
26wound healing, spreading of epidermal cells (GO:0035313)3.70246031
27microglial cell activation (GO:0001774)3.68852372
28positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.63587123
29regulation of vitamin D biosynthetic process (GO:0060556)3.59907905
30regulation of mononuclear cell migration (GO:0071675)3.55954079
31positive regulation of chemokine biosynthetic process (GO:0045080)3.54748155
32detection of molecule of bacterial origin (GO:0032490)3.53671222
33natural killer cell mediated immunity (GO:0002228)3.53311618
34natural killer cell mediated cytotoxicity (GO:0042267)3.53311618
35response to muramyl dipeptide (GO:0032495)3.51649297
36positive regulation of cellular amide metabolic process (GO:0034250)3.44066236
37chondrocyte proliferation (GO:0035988)3.42058118
38protein localization to endosome (GO:0036010)3.41770719
39cellular response to interferon-alpha (GO:0035457)3.40605668
40apoptotic cell clearance (GO:0043277)3.38633453
41positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.34532968
42positive regulation of heat generation (GO:0031652)3.34466118
43macrophage activation (GO:0042116)3.28896610
44regulation of cholesterol storage (GO:0010885)3.28438279
45low-density lipoprotein particle clearance (GO:0034383)3.27578660
46regulation of integrin activation (GO:0033623)3.26646655
47adhesion of symbiont to host (GO:0044406)3.24211556
48regulation of dendritic cell antigen processing and presentation (GO:0002604)3.17075456
49lipopolysaccharide-mediated signaling pathway (GO:0031663)3.16199071
50collagen catabolic process (GO:0030574)3.15565083
51positive regulation of macrophage cytokine production (GO:0060907)3.12408826
52response to interferon-alpha (GO:0035455)3.11160450
53collagen metabolic process (GO:0032963)3.07935252
54immunoglobulin mediated immune response (GO:0016064)3.04316996
55barbed-end actin filament capping (GO:0051016)3.02942762
56positive regulation of interferon-beta production (GO:0032728)3.00188458
57* substrate-dependent cell migration (GO:0006929)2.99826439
58keratan sulfate catabolic process (GO:0042340)2.99768274
59positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.95034187
60negative regulation of nitric oxide biosynthetic process (GO:0045019)2.92517868
61granulocyte activation (GO:0036230)2.92479696
62glycosphingolipid catabolic process (GO:0046479)2.89913830
63basement membrane organization (GO:0071711)2.86592732
64endothelium development (GO:0003158)2.85639731
65positive regulation of antigen processing and presentation (GO:0002579)2.84710354
66positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.83311065
67multicellular organismal macromolecule metabolic process (GO:0044259)2.83002789
68multicellular organismal catabolic process (GO:0044243)2.82729051
69regulation of fever generation (GO:0031620)2.81763756
70regulation of axon extension involved in axon guidance (GO:0048841)2.81499070
71lymphangiogenesis (GO:0001946)2.80883813
72NIK/NF-kappaB signaling (GO:0038061)2.80569951
73regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.79204550
74modulation by symbiont of host cellular process (GO:0044068)2.78318082
75monocyte chemotaxis (GO:0002548)2.77388565
76regulation of membrane protein ectodomain proteolysis (GO:0051043)2.77156267
77collagen fibril organization (GO:0030199)2.76391911
78respiratory burst (GO:0045730)2.76365391
79positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.75864714
80extracellular matrix disassembly (GO:0022617)2.75574754
81neutrophil activation (GO:0042119)2.74340197
82regulation of macrophage cytokine production (GO:0010935)2.72269713
83cellular response to type I interferon (GO:0071357)2.72125058
84type I interferon signaling pathway (GO:0060337)2.72125058
85response to type I interferon (GO:0034340)2.71670224
86neuron remodeling (GO:0016322)2.69006962
87myeloid cell activation involved in immune response (GO:0002275)2.68951866
88negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.67097338
89negative regulation of chondrocyte differentiation (GO:0032331)2.66969686
90endodermal cell differentiation (GO:0035987)2.66240186
91positive regulation of p38MAPK cascade (GO:1900745)2.65509845
92regulation of early endosome to late endosome transport (GO:2000641)2.65416809
93multicellular organismal metabolic process (GO:0044236)2.63754335
94positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.62822317
95branching involved in salivary gland morphogenesis (GO:0060445)2.61981162
96* axon extension (GO:0048675)2.61685048
97regulation of vitamin metabolic process (GO:0030656)2.61683209
98interferon-gamma-mediated signaling pathway (GO:0060333)2.61010474
99dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.60336099
100regulation of axon guidance (GO:1902667)2.57624026
101positive regulation of axon extension (GO:0045773)2.56868725
102hydrogen peroxide biosynthetic process (GO:0050665)2.55588499
103modification by symbiont of host morphology or physiology (GO:0044003)2.55338653
104negative regulation of axon extension involved in axon guidance (GO:0048843)2.54073573
105negative regulation of adherens junction organization (GO:1903392)2.53286744
106negative regulation of focal adhesion assembly (GO:0051895)2.53286744
107negative regulation of cell junction assembly (GO:1901889)2.53286744
108* semaphorin-plexin signaling pathway (GO:0071526)2.53216289
109positive regulation of gamma-delta T cell activation (GO:0046645)2.53073032
110wound healing, spreading of cells (GO:0044319)2.52342517
111negative regulation of interleukin-12 production (GO:0032695)2.52250207
112glycolipid catabolic process (GO:0019377)2.52242752
113negative regulation of platelet activation (GO:0010544)2.52164198
114regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.51958713
115negative regulation of lipid storage (GO:0010888)2.51956366
116craniofacial suture morphogenesis (GO:0097094)2.51818573
117planar cell polarity pathway involved in neural tube closure (GO:0090179)2.51059900
118regulation of interleukin-12 biosynthetic process (GO:0045075)2.50803626
119positive regulation vascular endothelial growth factor production (GO:0010575)2.50742801
120regulation of chemokine biosynthetic process (GO:0045073)2.50384099
121negative regulation of catenin import into nucleus (GO:0035414)2.49488932
122regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.48742111
123regulation of chemokine-mediated signaling pathway (GO:0070099)2.48422975
124positive regulation of chemokine production (GO:0032722)2.47810077
125substrate adhesion-dependent cell spreading (GO:0034446)2.47173717
126regulation of interleukin-8 biosynthetic process (GO:0045414)2.46761923
127cell migration involved in sprouting angiogenesis (GO:0002042)2.46130755
128regulation of podosome assembly (GO:0071801)2.44973511
129regulation of antigen processing and presentation (GO:0002577)2.44615081
130heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.43840204
131Notch signaling involved in heart development (GO:0061314)2.43339276
132plasma membrane repair (GO:0001778)2.43159408
133positive regulation of interleukin-6 production (GO:0032755)2.42743322
134chondrocyte development (GO:0002063)2.42419893
135endothelial cell morphogenesis (GO:0001886)2.41426204
136positive regulation of toll-like receptor signaling pathway (GO:0034123)2.41349697
137regulation of heat generation (GO:0031650)2.40798639
138extracellular fibril organization (GO:0043206)2.40312209
139hyaluronan catabolic process (GO:0030214)2.39328505
140blood vessel maturation (GO:0001955)2.38716136
141positive regulation of leukocyte degranulation (GO:0043302)2.37542121
142regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.37514584
143decidualization (GO:0046697)2.37309903
144regulation of nitric oxide biosynthetic process (GO:0045428)2.37171691
145cellular response to virus (GO:0098586)2.36749382
146* neuron projection extension involved in neuron projection guidance (GO:1902284)2.36675843
147* axon extension involved in axon guidance (GO:0048846)2.36675843
148positive regulation of interleukin-1 beta secretion (GO:0050718)2.36235335
149epithelial cell-cell adhesion (GO:0090136)2.36215288
150stress fiber assembly (GO:0043149)2.35473087
151regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.35112372
152negative regulation of interleukin-17 production (GO:0032700)2.34016715
153positive regulation of mast cell activation involved in immune response (GO:0033008)2.33234992
154positive regulation of mast cell degranulation (GO:0043306)2.33234992
155regulation of mast cell degranulation (GO:0043304)2.32934963
156positive regulation of interleukin-12 production (GO:0032735)2.32889591
157fibril organization (GO:0097435)2.32816846
158superoxide anion generation (GO:0042554)2.31212905
159glomerular visceral epithelial cell development (GO:0072015)2.30917116
160positive regulation of fat cell differentiation (GO:0045600)2.29351071
161oligosaccharide catabolic process (GO:0009313)2.28144277
162positive regulation of odontogenesis (GO:0042482)2.27563568
163endocytic recycling (GO:0032456)2.27503099
164positive regulation of nitric oxide biosynthetic process (GO:0045429)2.27484265
165platelet-derived growth factor receptor signaling pathway (GO:0048008)2.27258172
166branching involved in labyrinthine layer morphogenesis (GO:0060670)2.26871012
167cellular response to vitamin D (GO:0071305)2.26248059
168venous blood vessel morphogenesis (GO:0048845)2.25750413
169skin morphogenesis (GO:0043589)2.25269624
170* vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.23549122
171negative regulation of axon guidance (GO:1902668)2.22162231
172negative regulation of smooth muscle cell migration (GO:0014912)2.21977244
173positive regulation of endothelial cell apoptotic process (GO:2000353)2.21573136
174glomerular epithelial cell development (GO:0072310)2.20939812
175cell migration involved in heart development (GO:0060973)2.20744498
176Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.20193694
177regulation of cytokine secretion involved in immune response (GO:0002739)2.20126115

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse5.03518229
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.78532024
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.95827251
4* IRF8_27001747_Chip-Seq_BMDM_Mouse3.57839609
5* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.53670483
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.41537861
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.36664063
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.29958406
9* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.93079021
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.79543947
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.74105712
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.68687018
13RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.62582820
14TP63_17297297_ChIP-ChIP_HaCaT_Human2.50666616
15SMAD_19615063_ChIP-ChIP_OVARY_Human2.18830476
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.15062618
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.14050455
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.97980905
19MYB_21317192_ChIP-Seq_ERMYB_Mouse1.96803778
20VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.96412428
21VDR_24787735_ChIP-Seq_THP-1_Human1.93598656
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.93494533
23CDX2_19796622_ChIP-Seq_MESCs_Mouse1.90327037
24IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.89454768
25* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.86186110
26* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.86186110
27* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.85578320
28MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.83214051
29* EED_16625203_ChIP-ChIP_MESCs_Mouse1.83081750
30NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.80456826
31TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.77002760
32GATA2_21666600_ChIP-Seq_HMVEC_Human1.76788132
33STAT6_21828071_ChIP-Seq_BEAS2B_Human1.74741853
34* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.74204562
35* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.71420419
36* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.66785387
37* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.66505831
38* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.66377439
39PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.63875860
40ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.56723467
41CJUN_26792858_Chip-Seq_BT549_Human1.56378066
42* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.55715385
43* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.54850080
44* SPI1_23127762_ChIP-Seq_K562_Human1.51324157
45NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.50937903
46NRF2_20460467_ChIP-Seq_MEFs_Mouse1.50937903
47* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.49516117
48THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.47791838
49* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.46601843
50WT1_19549856_ChIP-ChIP_CCG9911_Human1.46585609
51PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.43711994
52* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.43175481
53TP53_20018659_ChIP-ChIP_R1E_Mouse1.40463824
54* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39652161
55* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.38513435
56NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.36482705
57NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.35802314
58BRD4_25478319_ChIP-Seq_HGPS_Human1.35679652
59CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.35484133
60* ELK3_25401928_ChIP-Seq_HUVEC_Human1.34214611
61* PU_27001747_Chip-Seq_BMDM_Mouse1.33170340
62* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.31393676
63* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.30845955
64* EZH2_27304074_Chip-Seq_ESCs_Mouse1.29949550
65* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.28502723
66* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.27544552
67ERG_21242973_ChIP-ChIP_JURKAT_Human1.25851965
68* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.24652119
69* RNF2_27304074_Chip-Seq_ESCs_Mouse1.24502296
70SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.23185972
71SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.23185972
72ZNF217_24962896_ChIP-Seq_MCF-7_Human1.20987035
73VDR_24763502_ChIP-Seq_THP-1_Human1.19553730
74STAT4_19710469_ChIP-ChIP_TH1__Mouse1.17965689
75FOXO3_23340844_ChIP-Seq_DLD1_Human1.17509482
76EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.16071942
77TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.15489451
78SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.14743440
79JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13590545
80CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.13573281
81SMAD3_21741376_ChIP-Seq_HESCs_Human1.13257833
82TP53_16413492_ChIP-PET_HCT116_Human1.12891495
83* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12667411
84* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.11413313
85JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10972960
86* RING1B_27294783_Chip-Seq_ESCs_Mouse1.10644173
87SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.09904442
88ESR1_21235772_ChIP-Seq_MCF-7_Human1.09422063
89* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09308904
90* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.07673189
91* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.07502827
92RXR_22108803_ChIP-Seq_LS180_Human1.06549021
93BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.06062651
94ESR2_21235772_ChIP-Seq_MCF-7_Human1.04167223
95* TP53_18474530_ChIP-ChIP_U2OS_Human1.02395433
96* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.02365488
97TBX20_22328084_ChIP-Seq_HEART_Mouse1.01889960
98TBX20_22080862_ChIP-Seq_HEART_Mouse1.01889960
99CLOCK_20551151_ChIP-Seq_293T_Human1.01597494
100* ISL1_27105846_Chip-Seq_CPCs_Mouse1.01131430
101* EZH2_27294783_Chip-Seq_ESCs_Mouse1.00822113
102KDM2B_26808549_Chip-Seq_DND41_Human1.00606834
103TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00162897
104* SOX2_20726797_ChIP-Seq_SW620_Human0.99745765
105ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.99323355
106WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.99012398
107HIF1A_21447827_ChIP-Seq_MCF-7_Human0.98229854
108* RING1B_27294783_Chip-Seq_NPCs_Mouse0.98158378
109AHR_22903824_ChIP-Seq_MCF-7_Human0.97638110
110RUNX_20019798_ChIP-Seq_JUKART_Human0.97477289
111CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96839056
112* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.96574546
113TCF7_22412390_ChIP-Seq_EML_Mouse0.96336193
114* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95081727
115KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.94517103
116* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94145734
117UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.93722189
118* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.93484318
119SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.93477554
120NR3C1_23031785_ChIP-Seq_PC12_Mouse0.93318995
121SALL4_18804426_ChIP-ChIP_XEN_Mouse0.91074463
122TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90783915
123KDM2B_26808549_Chip-Seq_K562_Human0.90009216
124MAF_26560356_Chip-Seq_TH1_Human0.87673879
125CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87412081
126UBF1/2_26484160_Chip-Seq_HMECs_Human0.86921373
127ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.86739742
128PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.86428675
129KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.85645851
130SOX9_24532713_ChIP-Seq_HFSC_Mouse0.84366932
131SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.82475301
132SPI1_23547873_ChIP-Seq_NB4_Human0.81751333
133STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.81428355
134CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.79468200
135VDR_21846776_ChIP-Seq_THP-1_Human0.79221220
136* EP300_21415370_ChIP-Seq_HL-1_Mouse0.78810878
137KDM2B_26808549_Chip-Seq_JURKAT_Human0.78340922
138* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.78230902
139FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.77112963
140RUNX1_22412390_ChIP-Seq_EML_Mouse0.75641348
141GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75321504
142* NFIB_24661679_ChIP-Seq_LUNG_Mouse0.75205606

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.39580221
2MP0008438_abnormal_cutaneous_collagen4.31852498
3MP0003303_peritoneal_inflammation3.80506081
4MP0005257_abnormal_intraocular_pressure3.04965353
5MP0003705_abnormal_hypodermis_morpholog2.98363681
6MP0005058_abnormal_lysosome_morphology2.86402481
7MP0004510_myositis2.86024377
8MP0003436_decreased_susceptibility_to2.59982319
9MP0001835_abnormal_antigen_presentation2.45097113
10MP0003172_abnormal_lysosome_physiology2.34981211
11MP0005275_abnormal_skin_tensile2.29073361
12MP0002419_abnormal_innate_immunity2.28213311
13MP0006082_CNS_inflammation2.26375319
14MP0009278_abnormal_bone_marrow2.25932972
15MP0004858_abnormal_nervous_system2.14044785
16MP0002998_abnormal_bone_remodeling2.12106517
17MP0010030_abnormal_orbit_morphology2.11638206
18MP0001958_emphysema2.06058927
19MP0001533_abnormal_skeleton_physiology2.05434106
20MP0009785_altered_susceptibility_to2.04033915
21MP0003091_abnormal_cell_migration1.98235342
22MP0003566_abnormal_cell_adhesion1.96546166
23MP0003448_altered_tumor_morphology1.94782524
24MP0005076_abnormal_cell_differentiation1.90505721
25MP0002877_abnormal_melanocyte_morpholog1.89471841
26MP0005000_abnormal_immune_tolerance1.84585866
27MP0002148_abnormal_hypersensitivity_rea1.82619843
28MP0003300_gastrointestinal_ulcer1.81749811
29MP0001849_ear_inflammation1.81203112
30MP0003279_aneurysm1.81151192
31MP0005595_abnormal_vascular_smooth1.80922064
32MP0005503_abnormal_tendon_morphology1.80432418
33MP0005167_abnormal_blood-brain_barrier1.77712745
34MP0003941_abnormal_skin_development1.75596694
35MP0003724_increased_susceptibility_to1.71345222
36MP0001790_abnormal_immune_system1.67703300
37MP0005387_immune_system_phenotype1.67703300
38* MP0001879_abnormal_lymphatic_vessel1.67384205
39MP0008004_abnormal_stomach_pH1.67134941
40MP0005025_abnormal_response_to1.64917072
41MP0002452_abnormal_antigen_presenting1.64602549
42MP0004947_skin_inflammation1.64101149
43MP0003329_amyloid_beta_deposits1.54670323
44MP0005248_abnormal_Harderian_gland1.53364038
45MP0000604_amyloidosis1.53192794
46MP0004272_abnormal_basement_membrane1.52218736
47MP0000343_altered_response_to1.51419120
48MP0000767_abnormal_smooth_muscle1.48253924
49MP0010307_abnormal_tumor_latency1.45190320
50MP0005390_skeleton_phenotype1.41294624
51MP0003950_abnormal_plasma_membrane1.40632772
52MP0000685_abnormal_immune_system1.38599676
53MP0000733_abnormal_muscle_development1.35279193
54MP0002723_abnormal_immune_serum1.30095155
55MP0003075_altered_response_to1.28760618
56MP0003634_abnormal_glial_cell1.28355948
57MP0001800_abnormal_humoral_immune1.25145292
58MP0003385_abnormal_body_wall1.24375586
59MP0003828_pulmonary_edema1.24125238
60MP0010352_gastrointestinal_tract_polyps1.23152301
61MP0002254_reproductive_system_inflammat1.22751204
62MP0005023_abnormal_wound_healing1.21485467
63MP0005464_abnormal_platelet_physiology1.19863595
64MP0005164_abnormal_response_to1.14919775
65MP0001819_abnormal_immune_cell1.14324931
66MP0009764_decreased_sensitivity_to1.11029472
67MP0002139_abnormal_hepatobiliary_system1.09253795
68MP0002420_abnormal_adaptive_immunity1.09220168
69MP0000534_abnormal_ureter_morphology1.09004537
70MP0005197_abnormal_uvea_morphology1.08913324
71MP0000371_diluted_coat_color1.07369579
72MP0004185_abnormal_adipocyte_glucose1.06092599
73MP0003045_fibrosis1.04320883
74MP0001542_abnormal_bone_strength1.04129590
75MP0005171_absent_coat_pigmentation1.04059649
76MP0005623_abnormal_meninges_morphology1.03551228
77MP0002896_abnormal_bone_mineralization1.02701772
78MP0001545_abnormal_hematopoietic_system1.02021614
79MP0005397_hematopoietic_system_phenotyp1.02021614
80MP0002405_respiratory_system_inflammati1.01684933
81MP0000858_altered_metastatic_potential1.01134038
82MP0002006_tumorigenesis1.00249240
83MP0009250_abnormal_appendicular_skeleto0.99850183
84MP0009840_abnormal_foam_cell0.99529222
85MP0003795_abnormal_bone_structure0.99469497
86MP0002332_abnormal_exercise_endurance0.97184306
87MP0005409_darkened_coat_color0.96723850
88MP0002933_joint_inflammation0.95923692
89MP0001614_abnormal_blood_vessel0.95370555
90MP0002295_abnormal_pulmonary_circulatio0.95114286
91MP0005165_increased_susceptibility_to0.94724684
92MP0005166_decreased_susceptibility_to0.94622426
93MP0001845_abnormal_inflammatory_respons0.93798212
94MP0003690_abnormal_glial_cell0.93781790
95MP0005193_abnormal_anterior_eye0.91305743
96MP0005174_abnormal_tail_pigmentation0.89826217
97MP0010368_abnormal_lymphatic_system0.89778919
98MP0000163_abnormal_cartilage_morphology0.89323272
99MP0000428_abnormal_craniofacial_morphol0.89107685
100MP0003136_yellow_coat_color0.89046103
101MP0005508_abnormal_skeleton_morphology0.87435190
102MP0000920_abnormal_myelination0.87260683
103MP0008469_abnormal_protein_level0.86361778
104MP0002166_altered_tumor_susceptibility0.83579419
105MP0000249_abnormal_blood_vessel0.83228673
106MP0000537_abnormal_urethra_morphology0.82851608
107MP0006054_spinal_hemorrhage0.82544443
108MP0003453_abnormal_keratinocyte_physiol0.82362150
109MP0001243_abnormal_dermal_layer0.81591968
110MP0009053_abnormal_anal_canal0.81071500
111MP0001915_intracranial_hemorrhage0.80458678
112MP0009384_cardiac_valve_regurgitation0.80205719
113MP0002115_abnormal_skeleton_extremities0.80014586
114MP0001851_eye_inflammation0.78335787
115MP0000015_abnormal_ear_pigmentation0.77713794
116MP0000432_abnormal_head_morphology0.77688249
117MP0002925_abnormal_cardiovascular_devel0.77336205
118MP0003191_abnormal_cellular_cholesterol0.77244150
119MP0002113_abnormal_skeleton_development0.76265641
120MP0005671_abnormal_response_to0.75485415
121MP0000049_abnormal_middle_ear0.74949952
122MP0002168_other_aberrant_phenotype0.74431723
123MP0003755_abnormal_palate_morphology0.73875453
124MP0001299_abnormal_eye_distance/0.73458241
125MP0010155_abnormal_intestine_physiology0.72673094
126MP0004130_abnormal_muscle_cell0.72448038
127MP0002092_abnormal_eye_morphology0.72278576
128MP0003935_abnormal_craniofacial_develop0.72107853
129MP0002277_abnormal_respiratory_mucosa0.69163498
130MP0002060_abnormal_skin_morphology0.67618972
131MP0005367_renal/urinary_system_phenotyp0.67337108
132MP0000516_abnormal_urinary_system0.67337108
133MP0003942_abnormal_urinary_system0.65596444
134MP0002116_abnormal_craniofacial_bone0.64954669
135MP0002932_abnormal_joint_morphology0.63383170
136MP0002697_abnormal_eye_size0.59904787
137* MP0000778_abnormal_nervous_system0.59594482

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)4.56740797
2Neurofibrillary tangles (HP:0002185)4.31524851
3Nuclear cataract (HP:0100018)4.26175912
4Eczematoid dermatitis (HP:0000976)4.18665219
5Recurrent bacterial skin infections (HP:0005406)4.17904319
6Premature rupture of membranes (HP:0001788)3.95959836
7Increased cerebral lipofuscin (HP:0011813)3.87720118
8Protrusio acetabuli (HP:0003179)3.81096950
9Recurrent gram-negative bacterial infections (HP:0005420)3.62042787
10Peritonitis (HP:0002586)3.51160882
11Arterial tortuosity (HP:0005116)3.41352978
12Abnormality of macrophages (HP:0004311)3.31757493
13Vascular tortuosity (HP:0004948)3.25765728
14Cerebral inclusion bodies (HP:0100314)3.13953380
15Hematochezia (HP:0002573)3.09600232
16Increased neuronal autofluorescent lipopigment (HP:0002074)3.05101553
17Mediastinal lymphadenopathy (HP:0100721)3.03608672
18Cerebral aneurysm (HP:0004944)3.02783296
19Disinhibition (HP:0000734)3.01756522
20Vertebral compression fractures (HP:0002953)2.98018654
21Gingivitis (HP:0000230)2.94111742
22Thick nail (HP:0001805)2.88948583
23Myocardial infarction (HP:0001658)2.83542240
24Osteolytic defects of the hand bones (HP:0009699)2.77207112
25Osteolytic defects of the phalanges of the hand (HP:0009771)2.77207112
26Shallow orbits (HP:0000586)2.72255153
27Aortic dissection (HP:0002647)2.69339802
28Prostate neoplasm (HP:0100787)2.68728070
29Autoimmune thrombocytopenia (HP:0001973)2.65991888
30Vacuolated lymphocytes (HP:0001922)2.64039237
31Spondylolisthesis (HP:0003302)2.62969480
32Ankle contracture (HP:0006466)2.62434675
33Axonal loss (HP:0003447)2.61963373
34Orchitis (HP:0100796)2.58020126
35Tetraparesis (HP:0002273)2.52705143
36Cervical subluxation (HP:0003308)2.48892617
37Periodontitis (HP:0000704)2.45340982
38Overgrowth (HP:0001548)2.45245847
39Follicular hyperkeratosis (HP:0007502)2.43424609
40Absent frontal sinuses (HP:0002688)2.43209098
41Spinal rigidity (HP:0003306)2.42744441
42Ulnar bowing (HP:0003031)2.42256212
43Dilatation of the ascending aorta (HP:0005111)2.41207057
44Diminished motivation (HP:0000745)2.39292637
45Abnormality of liposaccharide metabolism (HP:0010968)2.36565942
46Abnormality of glycosphingolipid metabolism (HP:0004343)2.36565942
47Abnormality of glycolipid metabolism (HP:0010969)2.36565942
48Mitral valve prolapse (HP:0001634)2.34546950
49Atrophic scars (HP:0001075)2.28325700
50Syringomyelia (HP:0003396)2.28071608
51Spinal cord lesions (HP:0100561)2.28071608
52Elevated erythrocyte sedimentation rate (HP:0003565)2.26350282
53Myositis (HP:0100614)2.25567761
54Broad metatarsal (HP:0001783)2.24606997
55Systemic lupus erythematosus (HP:0002725)2.24333648
56Recurrent skin infections (HP:0001581)2.22712928
57Premature loss of primary teeth (HP:0006323)2.22447550
58Genu recurvatum (HP:0002816)2.22222559
59Soft skin (HP:0000977)2.21086035
60Retrobulbar optic neuritis (HP:0100654)2.20107221
61Optic neuritis (HP:0100653)2.20107221
62Abnormality of dentin (HP:0010299)2.17536366
63Dysostosis multiplex (HP:0000943)2.16754683
64Mutism (HP:0002300)2.16603161
65Bladder diverticulum (HP:0000015)2.15816488
66Bone pain (HP:0002653)2.15037048
67Aortic aneurysm (HP:0004942)2.14730720
68Stomatitis (HP:0010280)2.14637530
69Basal ganglia calcification (HP:0002135)2.13897265
70Porencephaly (HP:0002132)2.13488720
71Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.10918436
72Abnormality of the vasculature of the conjunctiva (HP:0008054)2.06320075
73Frequent falls (HP:0002359)2.05553128
74Hypoplasia of the iris (HP:0007676)2.04743809
75Increased connective tissue (HP:0009025)2.04537805
76Wrist flexion contracture (HP:0001239)2.02753713
77Pathologic fracture (HP:0002756)2.00325305
78Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.99813271
79Interstitial pulmonary disease (HP:0006530)1.98969750
80Abnormality of glycosaminoglycan metabolism (HP:0004371)1.97525953
81Abnormality of mucopolysaccharide metabolism (HP:0011020)1.97525953
82Abnormality of polysaccharide metabolism (HP:0011012)1.97525953
83Zonular cataract (HP:0010920)1.97450910
84Wormian bones (HP:0002645)1.94832619
85Urinary glycosaminoglycan excretion (HP:0003541)1.94645807
86Mucopolysacchariduria (HP:0008155)1.94645807
87Radial bowing (HP:0002986)1.93842990
88Abnormality of the peritoneum (HP:0002585)1.92947504
89Chronic obstructive pulmonary disease (HP:0006510)1.92876033
90Obstructive lung disease (HP:0006536)1.92876033
91Blue sclerae (HP:0000592)1.92659448
92Fragile skin (HP:0001030)1.91287116
93Increased density of long bones (HP:0006392)1.90965524
94Short 4th metacarpal (HP:0010044)1.90337983
95Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.90337983
96Thin bony cortex (HP:0002753)1.88741615
97Esophageal varix (HP:0002040)1.86541813
98Alopecia of scalp (HP:0002293)1.86344855
99Arterial thrombosis (HP:0004420)1.86164293
100Biconcave vertebral bodies (HP:0004586)1.86145285
101Pulmonary artery stenosis (HP:0004415)1.86061008
102Abnormality of the frontal sinuses (HP:0002687)1.85226477
103Supranuclear gaze palsy (HP:0000605)1.83337163
104Cortical dysplasia (HP:0002539)1.82698892
105Turricephaly (HP:0000262)1.81812830
106Long toe (HP:0010511)1.81760863
107Ulnar claw (HP:0001178)1.81423016
108Joint stiffness (HP:0001387)1.81331511
109Femoral bowing (HP:0002980)1.81308744
110Ectopia lentis (HP:0001083)1.80845139
111Protuberant abdomen (HP:0001538)1.80412684
112Tibial bowing (HP:0002982)1.78773219
113Subacute progressive viral hepatitis (HP:0006572)1.76819321
114Cellulitis (HP:0100658)1.76483866
115Asymmetric septal hypertrophy (HP:0001670)1.76026654
116Loss of speech (HP:0002371)1.75737581
117Persistence of primary teeth (HP:0006335)1.75663678
118Natal tooth (HP:0000695)1.75496325
119Recurrent fungal infections (HP:0002841)1.75389457
120Short nail (HP:0001799)1.75236167
121Distal upper limb amyotrophy (HP:0007149)1.75161746
122Upper limb amyotrophy (HP:0009129)1.75161746
123Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.74757405
124Aneurysm (HP:0002617)1.74455657
125Hypoventilation (HP:0002791)1.74072563
126Glomerulonephritis (HP:0000099)1.73651258
127Inappropriate behavior (HP:0000719)1.72468846
128Hyperacusis (HP:0010780)1.72048915
129Hammertoe (HP:0001765)1.71897657
130Ovoid vertebral bodies (HP:0003300)1.71466154
131Vasculitis (HP:0002633)1.71024885
132Thoracolumbar scoliosis (HP:0002944)1.70919123
133Apathy (HP:0000741)1.70029505
134Nephritis (HP:0000123)1.67485959
135Hyperextensible skin (HP:0000974)1.67463336
136Hand muscle atrophy (HP:0009130)1.65955640
137Coxa vara (HP:0002812)1.65488256
138Neonatal short-limb short stature (HP:0008921)1.62430581
139Cupped ribs (HP:0000887)1.62396997
140Aortic regurgitation (HP:0001659)1.61794370
141Conjunctival telangiectasia (HP:0000524)1.61274487
142Osteopenia (HP:0000938)1.61120075
143Metaphyseal irregularity (HP:0003025)1.59786858
144White forelock (HP:0002211)1.59205319
145Segmental peripheral demyelination/remyelination (HP:0003481)1.58516891
146Skull defect (HP:0001362)1.57178246

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K143.45859512
2TTN3.16765921
3TBK12.93392220
4RIPK42.90749017
5DDR22.63367786
6TYK22.56599172
7RIPK12.40452950
8NTRK12.37307774
9KIT2.24939714
10JAK12.23141018
11GRK72.21991950
12TRIB32.04038198
13SIK12.00067456
14ERBB41.95695376
15TYRO31.94526044
16IKBKE1.92087003
17NME21.89956498
18ERN11.87067730
19BLK1.81150814
20SIK21.81085912
21JAK31.79650748
22IKBKB1.77665478
23IRAK31.75528110
24MAP3K131.69575728
25CAMK1D1.68437420
26PKN21.67985059
27BMX1.67280923
28IRAK41.67223507
29PDGFRA1.66131809
30LATS11.65490139
31TGFBR21.61239034
32PTK61.56032005
33PBK1.56030159
34CHUK1.51541409
35MARK11.49123155
36FGR1.48788494
37MET1.43802844
38CDC42BPA1.39697158
39CSF1R1.35230241
40NEK91.33915881
41MAP3K31.28810104
42CAMK1G1.27917733
43LIMK11.25930219
44EPHB21.25324680
45RPS6KA41.24297681
46CSK1.22895770
47TGFBR11.22439642
48CDK121.21574881
49MAP3K101.20082437
50HCK1.14239275
51STK31.10087583
52EPHA31.07488814
53DMPK1.06292301
54PDGFRB1.04538007
55TESK11.01715437
56CASK0.97506354
57MARK30.97174090
58FGFR30.96181833
59KDR0.93789462
60ERBB30.92197969
61CDK60.90963697
62LMTK20.89525489
63EGFR0.88890099
64EIF2AK20.86958396
65TAOK20.83877495
66PAK40.82045430
67JAK20.81326554
68TRPM70.81251848
69ROCK20.80776025
70EPHA20.80183444
71ABL20.80129154
72PIM20.79985430
73MAP3K110.75749846
74PLK20.75018233
75EPHB10.72917726
76MAP3K60.70935308
77PAK20.69342121
78ABL10.68978871
79MAP3K50.66138117
80MYLK0.65695655
81TIE10.65343726
82PTK20.65249007
83PTK2B0.63466036
84KSR10.63085563
85CLK10.61659847
86ADRBK20.61011072
87PRKD30.60925572
88ACVR1B0.60659732
89LCK0.60420091
90MTOR0.59237255
91FES0.58708803
92FYN0.58110137
93PKN10.56867923
94FLT30.56232432
95NTRK20.56211232
96LYN0.56092962
97LATS20.56040966
98FGFR40.55969527
99DAPK20.55823374
100INSR0.55067056
101MARK20.54549119
102MOS0.54238988
103SRC0.52599143
104MATK0.50295050
105SIK30.49845978
106STK100.49814978
107SCYL20.49812127
108GSK3A0.49540420
109PAK60.49462012
110DAPK30.49069887
111DYRK1B0.46986268
112LRRK20.46462864
113PRKD20.45827207
114MAPK70.44929034
115MST1R0.44677655
116ERBB20.44411600
117IGF1R0.43221971
118CDK150.40518968
119PIM10.40517736
120FER0.40406798
121RPS6KA20.39770272
122NUAK10.39742860
123RET0.39260506
124SYK0.39213310
125ALK0.39180843
126CDK140.38877106
127CDK180.38747109
128STK40.38744489
129TAOK30.37906444
130STK38L0.37716993
131ICK0.36396506
132TNIK0.35934376
133PRKCH0.35877363
134SGK10.35726996
135PRKCD0.34903891
136KSR20.34746382
137ROCK10.34727388
138ARAF0.32669354
139MAP3K90.31791367
140ZAP700.31662559
141CDK11A0.31179811
142TAOK10.31121392
143CSNK1A1L0.29567143
144EEF2K0.27589069
145CDK50.27096778

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.70106112
2Toll-like receptor signaling pathway_Homo sapiens_hsa046202.48780622
3Malaria_Homo sapiens_hsa051442.30077566
4Osteoclast differentiation_Homo sapiens_hsa043802.25791157
5Staphylococcus aureus infection_Homo sapiens_hsa051502.17503390
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.00878583
7Tuberculosis_Homo sapiens_hsa051521.99156502
8TNF signaling pathway_Homo sapiens_hsa046681.97475549
9Pertussis_Homo sapiens_hsa051331.84681983
10Lysosome_Homo sapiens_hsa041421.78677027
11Phagosome_Homo sapiens_hsa041451.77302013
12NOD-like receptor signaling pathway_Homo sapiens_hsa046211.77045400
13Toxoplasmosis_Homo sapiens_hsa051451.65753254
14Legionellosis_Homo sapiens_hsa051341.65646066
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.60472405
16Measles_Homo sapiens_hsa051621.56019201
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.54701529
18Influenza A_Homo sapiens_hsa051641.52159631
19AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.51870251
20Salmonella infection_Homo sapiens_hsa051321.50308207
21Rheumatoid arthritis_Homo sapiens_hsa053231.50229854
22Amoebiasis_Homo sapiens_hsa051461.49765126
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.46707602
24Bladder cancer_Homo sapiens_hsa052191.42711214
25Graft-versus-host disease_Homo sapiens_hsa053321.42315121
26ECM-receptor interaction_Homo sapiens_hsa045121.40271199
27Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.39096695
28Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.37540497
29Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.36287176
30B cell receptor signaling pathway_Homo sapiens_hsa046621.36045027
31Apoptosis_Homo sapiens_hsa042101.35378468
32Vibrio cholerae infection_Homo sapiens_hsa051101.31129219
33Viral myocarditis_Homo sapiens_hsa054161.30704865
34Chronic myeloid leukemia_Homo sapiens_hsa052201.27558234
35Focal adhesion_Homo sapiens_hsa045101.27247010
36Shigellosis_Homo sapiens_hsa051311.26523730
37Small cell lung cancer_Homo sapiens_hsa052221.23993936
38Proteoglycans in cancer_Homo sapiens_hsa052051.20947697
39African trypanosomiasis_Homo sapiens_hsa051431.19645885
40Type II diabetes mellitus_Homo sapiens_hsa049301.12447721
41Leukocyte transendothelial migration_Homo sapiens_hsa046701.11270404
42Chemokine signaling pathway_Homo sapiens_hsa040621.10646713
43Hepatitis C_Homo sapiens_hsa051601.10456705
44Hepatitis B_Homo sapiens_hsa051611.09834170
45MicroRNAs in cancer_Homo sapiens_hsa052061.04539657
46Allograft rejection_Homo sapiens_hsa053301.04424515
47Asthma_Homo sapiens_hsa053101.00901367
48Herpes simplex infection_Homo sapiens_hsa051680.99822769
49Neurotrophin signaling pathway_Homo sapiens_hsa047220.99446013
50Adherens junction_Homo sapiens_hsa045200.96356320
51Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.95391524
52Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.94396118
53Pancreatic cancer_Homo sapiens_hsa052120.93163997
54Sphingolipid metabolism_Homo sapiens_hsa006000.92993247
55Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.92976262
56Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.92183758
57Basal cell carcinoma_Homo sapiens_hsa052170.91434804
58Protein digestion and absorption_Homo sapiens_hsa049740.89915431
59Regulation of actin cytoskeleton_Homo sapiens_hsa048100.89613536
60Jak-STAT signaling pathway_Homo sapiens_hsa046300.89480452
61Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85742409
62Adipocytokine signaling pathway_Homo sapiens_hsa049200.85321696
63Collecting duct acid secretion_Homo sapiens_hsa049660.82477421
64Platelet activation_Homo sapiens_hsa046110.82156867
65Hematopoietic cell lineage_Homo sapiens_hsa046400.81547931
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81203699
67Glioma_Homo sapiens_hsa052140.80281730
68Prolactin signaling pathway_Homo sapiens_hsa049170.79661782
69Antigen processing and presentation_Homo sapiens_hsa046120.79303663
70TGF-beta signaling pathway_Homo sapiens_hsa043500.79127227
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78119802
72Dilated cardiomyopathy_Homo sapiens_hsa054140.77508024
73Hippo signaling pathway_Homo sapiens_hsa043900.76670787
74HIF-1 signaling pathway_Homo sapiens_hsa040660.75778168
75Dorso-ventral axis formation_Homo sapiens_hsa043200.74821493
76Acute myeloid leukemia_Homo sapiens_hsa052210.74484434
77Melanoma_Homo sapiens_hsa052180.73501022
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73378531
79Notch signaling pathway_Homo sapiens_hsa043300.73310343
80Renal cell carcinoma_Homo sapiens_hsa052110.72642412
81Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.71837474
82Other glycan degradation_Homo sapiens_hsa005110.71228609
83Insulin resistance_Homo sapiens_hsa049310.71128966
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69856341
85Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.69051189
86VEGF signaling pathway_Homo sapiens_hsa043700.68105494
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.67270353
88mTOR signaling pathway_Homo sapiens_hsa041500.66521031
89Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.66038694
90Intestinal immune network for IgA production_Homo sapiens_hsa046720.65684238
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64425206
92Ras signaling pathway_Homo sapiens_hsa040140.63923911
93Gap junction_Homo sapiens_hsa045400.63426739
94Prostate cancer_Homo sapiens_hsa052150.62445094
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60397113
96Hedgehog signaling pathway_Homo sapiens_hsa043400.59449697
97ErbB signaling pathway_Homo sapiens_hsa040120.58937901
98Rap1 signaling pathway_Homo sapiens_hsa040150.58733200
99Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.57728963
100PI3K-Akt signaling pathway_Homo sapiens_hsa041510.57620447
101Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57543738
102Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55996092
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55125782
104Endocytosis_Homo sapiens_hsa041440.55125512
105Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54580169
106Phospholipase D signaling pathway_Homo sapiens_hsa040720.53892290
107Viral carcinogenesis_Homo sapiens_hsa052030.53076806
108Tight junction_Homo sapiens_hsa045300.52713183
109Axon guidance_Homo sapiens_hsa043600.52353411
110Type I diabetes mellitus_Homo sapiens_hsa049400.52247829
111Melanogenesis_Homo sapiens_hsa049160.52083695
112HTLV-I infection_Homo sapiens_hsa051660.51973246
113T cell receptor signaling pathway_Homo sapiens_hsa046600.51635904
114Estrogen signaling pathway_Homo sapiens_hsa049150.51565250
115Synaptic vesicle cycle_Homo sapiens_hsa047210.51292140
116Caffeine metabolism_Homo sapiens_hsa002320.50633002
117Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49707633
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49657835
119GnRH signaling pathway_Homo sapiens_hsa049120.49546357
120Prion diseases_Homo sapiens_hsa050200.48921856
121Complement and coagulation cascades_Homo sapiens_hsa046100.48192572
122MAPK signaling pathway_Homo sapiens_hsa040100.47667904
123Colorectal cancer_Homo sapiens_hsa052100.47007238
124Galactose metabolism_Homo sapiens_hsa000520.46857793
125Pathways in cancer_Homo sapiens_hsa052000.46442419
126PPAR signaling pathway_Homo sapiens_hsa033200.45156465

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