NRN1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is extracellular and enhances both neurite growth and neuronal survival. The encoded protein is found both as a GPI anchored membrane-bound form and as a secreted form. This activity-related ligand functions as a homodimer or heterodimer. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein insertion into membrane (GO:0051205)8.77339473
2regulation of female gonad development (GO:2000194)6.52090447
3protein localization to cilium (GO:0061512)6.42232418
4negative regulation of cytosolic calcium ion concentration (GO:0051481)6.35628625
5protein polyglutamylation (GO:0018095)5.98476576
6chaperone-mediated protein transport (GO:0072321)5.12563309
7chromatin remodeling at centromere (GO:0031055)5.04718991
8adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.90478846
9response to pheromone (GO:0019236)4.86728689
10regulation of cilium movement (GO:0003352)4.85871526
11IMP biosynthetic process (GO:0006188)4.79167822
12CENP-A containing nucleosome assembly (GO:0034080)4.77138573
13detection of light stimulus involved in visual perception (GO:0050908)4.70711476
14detection of light stimulus involved in sensory perception (GO:0050962)4.70711476
15establishment of protein localization to mitochondrial membrane (GO:0090151)4.67234392
16behavioral response to cocaine (GO:0048148)4.63916955
17proteasome assembly (GO:0043248)4.57640364
18potassium ion export (GO:0071435)4.47607844
19rRNA modification (GO:0000154)4.46663118
20telomere maintenance via semi-conservative replication (GO:0032201)4.40023896
21L-alpha-amino acid transmembrane transport (GO:1902475)4.38394269
22activation of protein kinase A activity (GO:0034199)4.37210622
23IMP metabolic process (GO:0046040)4.25482134
24DNA replication-independent nucleosome assembly (GO:0006336)4.16233676
25DNA replication-independent nucleosome organization (GO:0034724)4.16233676
26establishment of integrated proviral latency (GO:0075713)4.10714105
27mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.09781385
28rRNA methylation (GO:0031167)4.08117493
29photoreceptor cell maintenance (GO:0045494)4.07203032
30potassium ion homeostasis (GO:0055075)4.06819374
31neuron cell-cell adhesion (GO:0007158)4.05603523
32detection of calcium ion (GO:0005513)4.05254979
33DNA strand elongation involved in DNA replication (GO:0006271)4.04382355
34synaptic vesicle exocytosis (GO:0016079)4.01539299
35G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.01141907
36spliceosomal snRNP assembly (GO:0000387)3.99569171
37purine nucleobase biosynthetic process (GO:0009113)3.99436151
38regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.94219809
39regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.94219809
40axonemal dynein complex assembly (GO:0070286)3.91916152
41DNA replication checkpoint (GO:0000076)3.91279361
42histone exchange (GO:0043486)3.86869776
43negative regulation of telomerase activity (GO:0051974)3.86576325
44DNA strand elongation (GO:0022616)3.80661099
45transcription elongation from RNA polymerase III promoter (GO:0006385)3.78999148
46termination of RNA polymerase III transcription (GO:0006386)3.78999148
47positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.77916376
48intraciliary transport (GO:0042073)3.77684052
49dopamine receptor signaling pathway (GO:0007212)3.76679655
50cilium morphogenesis (GO:0060271)3.75666282
51negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.72787439
52microtubule severing (GO:0051013)3.71876454
53cellular potassium ion homeostasis (GO:0030007)3.69575615
54negative regulation of mitotic sister chromatid separation (GO:2000816)3.68756894
55negative regulation of sister chromatid segregation (GO:0033046)3.68756894
56negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.68756894
57negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.68756894
58negative regulation of mitotic sister chromatid segregation (GO:0033048)3.68756894
59L-serine metabolic process (GO:0006563)3.68583900
60urinary tract smooth muscle contraction (GO:0014848)3.67387177
61telomere maintenance via recombination (GO:0000722)3.67327630
62exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.66191398
63maturation of SSU-rRNA (GO:0030490)3.65280386
64regulation of helicase activity (GO:0051095)3.65219829
65respiratory chain complex IV assembly (GO:0008535)3.64398830
66heterochromatin organization (GO:0070828)3.61759696
67nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.61263089
68cellular response to glucagon stimulus (GO:0071377)3.57621212
69positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.56998678
70energy coupled proton transport, down electrochemical gradient (GO:0015985)3.55439421
71ATP synthesis coupled proton transport (GO:0015986)3.55439421
72detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.54481702
73detection of temperature stimulus involved in sensory perception (GO:0050961)3.54481702
74ribosomal small subunit assembly (GO:0000028)3.54025544
75protein complex localization (GO:0031503)3.53787945
76regulation of voltage-gated calcium channel activity (GO:1901385)3.52685598
77negative regulation of chromosome segregation (GO:0051985)3.52071379
78response to caffeine (GO:0031000)3.50942264
79potassium ion transmembrane transport (GO:0071805)3.50000477
80cellular potassium ion transport (GO:0071804)3.50000477
81glutamate secretion (GO:0014047)3.49477594
82mitotic spindle checkpoint (GO:0071174)3.49066339
83spindle checkpoint (GO:0031577)3.49040585
84nodal signaling pathway (GO:0038092)3.47199660
85regulation of nuclear cell cycle DNA replication (GO:0033262)3.46676622
86mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.45964551
87histone mRNA metabolic process (GO:0008334)3.45844054
88nucleobase biosynthetic process (GO:0046112)3.45591846
89synaptic vesicle endocytosis (GO:0048488)3.45436659
90negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.44963890
91pseudouridine synthesis (GO:0001522)3.44537420
92regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.42751407
93mitochondrial DNA replication (GO:0006264)3.40795782
94termination of RNA polymerase II transcription (GO:0006369)3.39900485
95regulation of chromatin binding (GO:0035561)3.39459464
96negative regulation of DNA-dependent DNA replication (GO:2000104)3.37381135
97cytochrome complex assembly (GO:0017004)3.37283014
98DNA catabolic process, exonucleolytic (GO:0000738)3.34210352
99regulation of mitochondrial translation (GO:0070129)3.34200875
100telomere maintenance via telomere lengthening (GO:0010833)3.34075737
101negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.33497761
102negative regulation of ligase activity (GO:0051352)3.33497761
103cellular protein complex localization (GO:0034629)3.31372410
104viral transcription (GO:0019083)3.31222239
105mitotic recombination (GO:0006312)3.29567740
106neuronal action potential (GO:0019228)3.27061498
107translational termination (GO:0006415)3.25567444
108regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.25535533
109regulation of mitotic spindle checkpoint (GO:1903504)3.25535533
110regulation of neurotransmitter uptake (GO:0051580)3.25137045
111mitotic spindle assembly checkpoint (GO:0007094)3.24820621
112anterior/posterior axis specification, embryo (GO:0008595)3.24465717
113mating behavior (GO:0007617)3.24458091
114protein neddylation (GO:0045116)3.24125764
115establishment of viral latency (GO:0019043)3.22314074
116potassium ion transport (GO:0006813)3.22081345
117regulation of synaptic vesicle exocytosis (GO:2000300)3.22035731
118cAMP biosynthetic process (GO:0006171)3.21486933
119transcription-coupled nucleotide-excision repair (GO:0006283)3.21175537
120otic vesicle formation (GO:0030916)3.18578361
121DNA damage response, detection of DNA damage (GO:0042769)3.16712646
122spindle assembly checkpoint (GO:0071173)3.15989649
123single strand break repair (GO:0000012)3.15874101
124regulation of gene silencing by RNA (GO:0060966)3.15729315
125regulation of posttranscriptional gene silencing (GO:0060147)3.15729315
126regulation of gene silencing by miRNA (GO:0060964)3.15729315
127membrane depolarization during action potential (GO:0086010)3.15689760
128axoneme assembly (GO:0035082)3.14886995
129DNA double-strand break processing (GO:0000729)3.14475874
130regulation of cell communication by electrical coupling (GO:0010649)3.13768174
131peristalsis (GO:0030432)3.13730876
132DNA-templated transcription, termination (GO:0006353)3.13156304
133ribosome assembly (GO:0042255)3.13104242
134sensory perception of taste (GO:0050909)3.12324268
135striatum development (GO:0021756)3.11804626
136ribosomal large subunit biogenesis (GO:0042273)3.11423197
137mitotic metaphase plate congression (GO:0007080)3.11167567
138regulation of sodium ion transmembrane transporter activity (GO:2000649)3.10029738
139sodium ion export (GO:0071436)3.09670617
140respiratory electron transport chain (GO:0022904)3.08341188
141positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.08164781
142anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.08059256
143protein complex biogenesis (GO:0070271)3.07754292
144water-soluble vitamin biosynthetic process (GO:0042364)3.06477194
145regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.04927376
146protein targeting to mitochondrion (GO:0006626)3.02861042
147translation (GO:0006412)3.02141049
148innate immune response in mucosa (GO:0002227)3.00964399
149auditory receptor cell differentiation (GO:0042491)3.00958704
150cilium movement (GO:0003341)3.00851399
151regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.00392220
152negative regulation of mitosis (GO:0045839)2.99823350
153spliceosomal complex assembly (GO:0000245)2.99365722
154protein localization to kinetochore (GO:0034501)2.99300969
155translational initiation (GO:0006413)2.98591106
156electron transport chain (GO:0022900)2.98565074
157antibacterial humoral response (GO:0019731)2.98367606
158negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.97838291
159regulation of microtubule-based movement (GO:0060632)2.96413911
160negative regulation of cation channel activity (GO:2001258)2.96099440
161phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.95450076
162mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.95287078
163mitochondrial respiratory chain complex I assembly (GO:0032981)2.95287078
164NADH dehydrogenase complex assembly (GO:0010257)2.95287078
165regulation of synaptic vesicle transport (GO:1902803)2.93480576
166rhodopsin mediated signaling pathway (GO:0016056)2.93467994
167replication fork processing (GO:0031297)2.93455287
168membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.92959922
169negative regulation of complement activation (GO:0045916)2.90793768
170regulation of heart rate by cardiac conduction (GO:0086091)2.90318649
171epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.90118286
172atrial cardiac muscle cell action potential (GO:0086014)2.90098546
173regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.89977477
174melanosome transport (GO:0032402)2.85833829
175response to amphetamine (GO:0001975)2.84376409
176calcium-mediated signaling using intracellular calcium source (GO:0035584)2.83211230
177response to glucagon (GO:0033762)2.82591190
178nonmotile primary cilium assembly (GO:0035058)2.81984436
179synaptic transmission, dopaminergic (GO:0001963)2.81745460
180detection of temperature stimulus (GO:0016048)2.81616706
181regulation of neurotransmitter transport (GO:0051588)2.80730238
182retinal rod cell development (GO:0046548)2.79921185
183olfactory bulb development (GO:0021772)2.79845607
184cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.79248146
185regulation of neurotransmitter secretion (GO:0046928)2.78452115
186adipose tissue development (GO:0060612)2.77957031
187neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.77698475
188regulation of short-term neuronal synaptic plasticity (GO:0048172)2.77524761
189behavioral response to ethanol (GO:0048149)2.76898912
190regulation of membrane repolarization (GO:0060306)2.76800905
191establishment of melanosome localization (GO:0032401)2.76620936
192microtubule bundle formation (GO:0001578)2.74201700
193regulation of sodium ion transmembrane transport (GO:1902305)2.72721684
194membrane hyperpolarization (GO:0060081)2.70779223
195membrane repolarization (GO:0086009)2.69527568
196positive regulation of synapse maturation (GO:0090129)2.69022392
197pigment granule transport (GO:0051904)2.68577342
198gamma-aminobutyric acid signaling pathway (GO:0007214)2.68385574
199sensory perception of smell (GO:0007608)16.3142753
200sensory perception of chemical stimulus (GO:0007606)10.0106580

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.62162642
2EZH2_22144423_ChIP-Seq_EOC_Human5.57898452
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.81849443
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.37241502
5MYC_18555785_ChIP-Seq_MESCs_Mouse4.07088147
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.92273042
7GBX2_23144817_ChIP-Seq_PC3_Human3.84925846
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.72231415
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.66450784
10E2F4_17652178_ChIP-ChIP_JURKAT_Human3.19367911
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.19316371
12ETS1_20019798_ChIP-Seq_JURKAT_Human3.04538870
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.96878512
14TAF15_26573619_Chip-Seq_HEK293_Human2.94190448
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.92635712
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.87116039
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.84809440
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.82893362
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.74868554
20VDR_22108803_ChIP-Seq_LS180_Human2.71160074
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.66217999
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.65436829
23MYC_18358816_ChIP-ChIP_MESCs_Mouse2.61005044
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.46998885
25FOXP3_21729870_ChIP-Seq_TREG_Human2.41227090
26NELFA_20434984_ChIP-Seq_ESCs_Mouse2.36389992
27BMI1_23680149_ChIP-Seq_NPCS_Mouse2.30457308
28REST_21632747_ChIP-Seq_MESCs_Mouse2.22320305
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.20442232
30VDR_23849224_ChIP-Seq_CD4+_Human2.16188448
31XRN2_22483619_ChIP-Seq_HELA_Human2.12485531
32THAP11_20581084_ChIP-Seq_MESCs_Mouse2.11276432
33JARID2_20064375_ChIP-Seq_MESCs_Mouse2.11135978
34* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.10566935
35ZFP57_27257070_Chip-Seq_ESCs_Mouse2.09645202
36SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.09538390
37DCP1A_22483619_ChIP-Seq_HELA_Human2.08439126
38PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.05308932
39PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.04873195
40ELK1_19687146_ChIP-ChIP_HELA_Human2.02989627
41KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.01756623
42KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.01756623
43KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.01756623
44FOXM1_23109430_ChIP-Seq_U2OS_Human1.99872408
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.94160251
46NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.92856060
47TTF2_22483619_ChIP-Seq_HELA_Human1.92465448
48RNF2_27304074_Chip-Seq_NSC_Mouse1.91168933
49DROSHA_22980978_ChIP-Seq_HELA_Human1.89026250
50EED_16625203_ChIP-ChIP_MESCs_Mouse1.88837961
51GABP_19822575_ChIP-Seq_HepG2_Human1.88492769
52CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88283254
53SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.87030619
54EZH2_18974828_ChIP-Seq_MESCs_Mouse1.85472244
55RNF2_18974828_ChIP-Seq_MESCs_Mouse1.85472244
56MTF2_20144788_ChIP-Seq_MESCs_Mouse1.84092135
57SUZ12_27294783_Chip-Seq_ESCs_Mouse1.82641034
58YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.79526059
59GATA1_26923725_Chip-Seq_HPCs_Mouse1.77388831
60SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.75911137
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.72960591
62MYCN_18555785_ChIP-Seq_MESCs_Mouse1.72491398
63SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.71646177
64MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.71368087
65YY1_21170310_ChIP-Seq_MESCs_Mouse1.70605074
66NANOG_16153702_ChIP-ChIP_HESCs_Human1.70539960
67JARID2_20075857_ChIP-Seq_MESCs_Mouse1.70501874
68EZH2_27294783_Chip-Seq_ESCs_Mouse1.68511661
69SRF_21415370_ChIP-Seq_HL-1_Mouse1.67040031
70POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.66687417
71SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.66334809
72SMAD4_21799915_ChIP-Seq_A2780_Human1.64676564
73* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.63423562
74RNF2_27304074_Chip-Seq_ESCs_Mouse1.61964268
75ZNF263_19887448_ChIP-Seq_K562_Human1.61614648
76EZH2_27304074_Chip-Seq_ESCs_Mouse1.60873732
77NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.60532488
78RBPJ_22232070_ChIP-Seq_NCS_Mouse1.60348710
79BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.59268549
80CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57737863
81ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.56977916
82MYC_18940864_ChIP-ChIP_HL60_Human1.56829693
83TOP2B_26459242_ChIP-Seq_MCF-7_Human1.55519834
84NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.53028177
85IKZF1_21737484_ChIP-ChIP_HCT116_Human1.52712760
86P300_19829295_ChIP-Seq_ESCs_Human1.51741966
87HOXB4_20404135_ChIP-ChIP_EML_Mouse1.51384156
88REST_18959480_ChIP-ChIP_MESCs_Mouse1.49405382
89CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.49391905
90ESR1_20079471_ChIP-ChIP_T-47D_Human1.48327712
91MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.46331132
92GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.45260639
93SOX2_16153702_ChIP-ChIP_HESCs_Human1.43740108
94P53_22127205_ChIP-Seq_FIBROBLAST_Human1.41585419
95PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40488270
96DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.39731299
97SMAD4_21741376_ChIP-Seq_EPCs_Human1.37348393
98TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.36900440
99ER_23166858_ChIP-Seq_MCF-7_Human1.36801851
100RARB_27405468_Chip-Seq_BRAIN_Mouse1.35870157
101SOX2_18555785_ChIP-Seq_MESCs_Mouse1.35865906
102ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.35846957
103E2F1_21310950_ChIP-Seq_MCF-7_Human1.34515486
104NOTCH1_21737748_ChIP-Seq_TLL_Human1.32811685
105TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.31746997
106POU5F1_16153702_ChIP-ChIP_HESCs_Human1.31148943
107NANOG_18555785_ChIP-Seq_MESCs_Mouse1.30784693
108E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.30602655
109SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.30042825
110SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30017648
111TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29906954
112POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.29906954
113ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.29775552
114SMAD3_21741376_ChIP-Seq_EPCs_Human1.29060933
115AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28916616
116SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27971387
117TCF3_18692474_ChIP-Seq_MEFs_Mouse1.27731860
118SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.25859751
119CBX2_27304074_Chip-Seq_ESCs_Mouse1.25612502
120SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24941772
121KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.24936311
122CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.23594345
123PRDM14_20953172_ChIP-Seq_ESCs_Human1.23578335
124RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22990653
125PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22986800
126ZFX_18555785_ChIP-Seq_MESCs_Mouse1.22629068
127POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.20868387
128FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.20758531
129BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.20086034
130ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.19323154
131UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18203804
132LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18141515
133MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.18116761
134STAT3_23295773_ChIP-Seq_U87_Human1.16484179
135RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.15657954
136CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.14170052
137LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13961577
138SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.13542900
139OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13203484
140BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.12275653
141ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12213250
142OCT4_20526341_ChIP-Seq_ESCs_Human1.12077760
143IGF1R_20145208_ChIP-Seq_DFB_Human1.12007358
144NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11675783
145PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.10959526
146NANOG_20526341_ChIP-Seq_ESCs_Human1.10751514
147POU3F2_20337985_ChIP-ChIP_501MEL_Human1.10730090
148AHR_22903824_ChIP-Seq_MCF-7_Human1.10202626
149NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08316280
150ELF1_17652178_ChIP-ChIP_JURKAT_Human1.07921440
151PIAS1_25552417_ChIP-Seq_VCAP_Human1.07629983
152SMAD4_21741376_ChIP-Seq_HESCs_Human1.07291189
153PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.07177790
154ARNT_22903824_ChIP-Seq_MCF-7_Human1.06598332
155JUN_21703547_ChIP-Seq_K562_Human1.05988801
156AR_21909140_ChIP-Seq_LNCAP_Human1.05610810
157SMAD_19615063_ChIP-ChIP_OVARY_Human1.04682950
158NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.03508701
159CTBP2_25329375_ChIP-Seq_LNCAP_Human1.03468557
160TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02842278
161KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.02166571
162KDM5A_27292631_Chip-Seq_BREAST_Human1.01805681
163CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.00932157
164TAL1_26923725_Chip-Seq_HPCs_Mouse1.00919152
165NCOR_22424771_ChIP-Seq_293T_Human1.00529132
166* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.99183261
167POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.98831231
168CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.98682537
169NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.97055777
170RING1B_27294783_Chip-Seq_ESCs_Mouse0.96976109
171SOX2_21211035_ChIP-Seq_LN229_Gbm0.96377937
172ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.96356508
173ETV2_25802403_ChIP-Seq_MESCs_Mouse0.95720291
174ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.95485902
175KDM2B_26808549_Chip-Seq_K562_Human0.94182649
176CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.92988310
177FOXP1_21924763_ChIP-Seq_HESCs_Human0.92045417
178CIITA_25753668_ChIP-Seq_RAJI_Human0.91989346
179BCAT_22108803_ChIP-Seq_LS180_Human0.91749468
180CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.91708412
181FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.91113151
182MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90600424
183SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.89852667
184RUNX1_26923725_Chip-Seq_HPCs_Mouse0.89828118
185TP63_19390658_ChIP-ChIP_HaCaT_Human0.89370419
186NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.86737140
187CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.84532811
188STAT3_1855785_ChIP-Seq_MESCs_Mouse0.84104078
189OCT4_18692474_ChIP-Seq_MEFs_Mouse0.83185257
190SOX2_18692474_ChIP-Seq_MEFs_Mouse0.83017286
191KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.82864358
192HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.82727900
193TCF3_18692474_ChIP-Seq_MESCs_Mouse0.82561268
194ZNF274_21170338_ChIP-Seq_K562_Hela0.81612291
195TFEB_21752829_ChIP-Seq_HELA_Human0.80030918
196* CTCF_18555785_ChIP-Seq_MESCs_Mouse0.78270770
197POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.77909161

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat4.89578576
2MP0003890_abnormal_embryonic-extraembry4.05411125
3MP0003941_abnormal_skin_development3.87397612
4MP0008789_abnormal_olfactory_epithelium3.44441506
5MP0004957_abnormal_blastocyst_morpholog3.43384196
6MP0003136_yellow_coat_color3.29897610
7MP0008058_abnormal_DNA_repair3.15996033
8MP0005499_abnormal_olfactory_system3.09711999
9MP0005394_taste/olfaction_phenotype3.09711999
10MP0003567_abnormal_fetal_cardiomyocyte2.91271482
11MP0002734_abnormal_mechanical_nocicepti2.63720248
12MP0002184_abnormal_innervation2.55528086
13MP0003111_abnormal_nucleus_morphology2.54990133
14MP0005551_abnormal_eye_electrophysiolog2.50481546
15MP0003880_abnormal_central_pattern2.45827413
16MP0010094_abnormal_chromosome_stability2.36590475
17MP0002653_abnormal_ependyma_morphology2.23518818
18MP0004133_heterotaxia2.19873860
19MP0001968_abnormal_touch/_nociception2.18201184
20MP0002735_abnormal_chemical_nociception2.13875672
21MP0003077_abnormal_cell_cycle2.10597936
22MP0002272_abnormal_nervous_system2.05724569
23MP0002736_abnormal_nociception_after2.03271358
24MP0001984_abnormal_olfaction13.2265564
25MP0004270_analgesia1.94003057
26MP0001485_abnormal_pinna_reflex1.89939358
27MP0009672_abnormal_birth_weight1.89769531
28MP0001529_abnormal_vocalization1.89496441
29MP0008877_abnormal_DNA_methylation1.85649905
30MP0005645_abnormal_hypothalamus_physiol1.82847344
31MP0008932_abnormal_embryonic_tissue1.82278191
32MP0002822_catalepsy1.77457253
33MP0008007_abnormal_cellular_replicative1.76514820
34MP0003119_abnormal_digestive_system1.74505644
35MP0008995_early_reproductive_senescence1.73795156
36MP0001293_anophthalmia1.72624901
37MP0001970_abnormal_pain_threshold1.71024704
38MP0003635_abnormal_synaptic_transmissio1.70340274
39MP0003315_abnormal_perineum_morphology1.69432716
40MP0006276_abnormal_autonomic_nervous1.67501498
41MP0002752_abnormal_somatic_nervous1.65305298
42MP0001661_extended_life_span1.65099433
43MP0001188_hyperpigmentation1.64246557
44MP0002277_abnormal_respiratory_mucosa1.63730935
45MP0003786_premature_aging1.59226864
46MP0005646_abnormal_pituitary_gland1.58161136
47MP0003186_abnormal_redox_activity1.56748003
48MP0001486_abnormal_startle_reflex1.55925726
49MP0001730_embryonic_growth_arrest1.53351816
50MP0004264_abnormal_extraembryonic_tissu1.49321121
51MP0004145_abnormal_muscle_electrophysio1.44402718
52MP0005451_abnormal_body_composition1.43956282
53MP0005379_endocrine/exocrine_gland_phen1.38120874
54MP0004859_abnormal_synaptic_plasticity1.37184820
55MP0008057_abnormal_DNA_replication1.36954666
56MP0009697_abnormal_copulation1.36949967
57MP0003123_paternal_imprinting1.36308780
58MP0002882_abnormal_neuron_morphology1.35660841
59MP0000350_abnormal_cell_proliferation1.35494170
60MP0002064_seizures1.35100943
61MP0003806_abnormal_nucleotide_metabolis1.32776135
62MP0009379_abnormal_foot_pigmentation1.31804020
63MP0009046_muscle_twitch1.31103400
64MP0002063_abnormal_learning/memory/cond1.30319329
65MP0002067_abnormal_sensory_capabilities1.30262151
66MP0001672_abnormal_embryogenesis/_devel1.28784016
67MP0005380_embryogenesis_phenotype1.28784016
68MP0003221_abnormal_cardiomyocyte_apopto1.28217837
69MP0006036_abnormal_mitochondrial_physio1.27954256
70MP0001764_abnormal_homeostasis1.26474783
71MP0003787_abnormal_imprinting1.22003487
72MP0002557_abnormal_social/conspecific_i1.21752274
73MP0002572_abnormal_emotion/affect_behav1.20505600
74MP0002229_neurodegeneration1.18765447
75MP0005410_abnormal_fertilization1.17109031
76MP0001697_abnormal_embryo_size1.16776296
77MP0002733_abnormal_thermal_nociception1.16522977
78MP0009745_abnormal_behavioral_response1.15056221
79MP0002163_abnormal_gland_morphology1.13157022
80MP0003195_calcinosis1.12829412
81MP0006072_abnormal_retinal_apoptosis1.12788770
82MP0003718_maternal_effect1.11845674
83MP0005423_abnormal_somatic_nervous1.11453895
84MP0001905_abnormal_dopamine_level1.09021059
85MP0002132_abnormal_respiratory_system1.08988980
86MP0003984_embryonic_growth_retardation1.07715260
87MP0002088_abnormal_embryonic_growth/wei1.06555285
88MP0002160_abnormal_reproductive_system1.05511917
89MP0002085_abnormal_embryonic_tissue1.05283716
90MP0000372_irregular_coat_pigmentation1.04794653
91MP0005367_renal/urinary_system_phenotyp1.04703877
92MP0000516_abnormal_urinary_system1.04703877
93MP0005195_abnormal_posterior_eye1.04188512
94MP0002090_abnormal_vision1.02448814
95MP0001542_abnormal_bone_strength1.00550391
96MP0002080_prenatal_lethality1.00291501
97MP0010030_abnormal_orbit_morphology0.99604187
98MP0003121_genomic_imprinting0.99369333
99MP0002396_abnormal_hematopoietic_system0.97497794
100MP0010386_abnormal_urinary_bladder0.97464758
101MP0004811_abnormal_neuron_physiology0.97254756
102MP0000778_abnormal_nervous_system0.96354983
103MP0003646_muscle_fatigue0.95774321
104MP0009703_decreased_birth_body0.95576802
105MP0001502_abnormal_circadian_rhythm0.95463833
106MP0002084_abnormal_developmental_patter0.95357204
107MP0004142_abnormal_muscle_tone0.94114141
108MP0001346_abnormal_lacrimal_gland0.93571189
109MP0003937_abnormal_limbs/digits/tail_de0.89570545
110MP0004742_abnormal_vestibular_system0.89401382
111MP0000955_abnormal_spinal_cord0.86982523
112MP0002086_abnormal_extraembryonic_tissu0.86533998
113MP0000313_abnormal_cell_death0.84630871
114MP0003122_maternal_imprinting0.84352959
115MP0003879_abnormal_hair_cell0.83364558
116MP0000631_abnormal_neuroendocrine_gland0.83256821
117MP0000647_abnormal_sebaceous_gland0.83179100
118MP0002152_abnormal_brain_morphology0.82935065
119MP0001286_abnormal_eye_development0.82664543
120MP0003634_abnormal_glial_cell0.82564724
121MP0002909_abnormal_adrenal_gland0.81885724
122MP0005084_abnormal_gallbladder_morpholo0.81634864
123MP0004036_abnormal_muscle_relaxation0.81269888
124MP0004924_abnormal_behavior0.80577541
125MP0005386_behavior/neurological_phenoty0.80577541
126MP0008260_abnormal_autophagy0.79636617
127MP0003011_delayed_dark_adaptation0.79479423
128MP0002751_abnormal_autonomic_nervous0.73589208
129MP0003693_abnormal_embryo_hatching0.71993410
130MP0002210_abnormal_sex_determination0.71860719
131MP0001145_abnormal_male_reproductive0.71382203
132MP0002233_abnormal_nose_morphology0.70400695
133MP0004782_abnormal_surfactant_physiolog0.69807421
134MP0005253_abnormal_eye_physiology0.69717692
135MP0004197_abnormal_fetal_growth/weight/0.69675194
136MP0002332_abnormal_exercise_endurance0.69421434
137MP0002111_abnormal_tail_morphology0.69402082
138MP0002066_abnormal_motor_capabilities/c0.69292337
139MP0004215_abnormal_myocardial_fiber0.69003706
140MP0002638_abnormal_pupillary_reflex0.68968988
141MP0000049_abnormal_middle_ear0.67870244
142MP0002796_impaired_skin_barrier0.67856350
143MP0002928_abnormal_bile_duct0.67052550
144MP0000358_abnormal_cell_content/0.66280652
145MP0003938_abnormal_ear_development0.65370507
146MP0001963_abnormal_hearing_physiology0.65297551
147MP0004858_abnormal_nervous_system0.65186069
148MP0001929_abnormal_gametogenesis0.65064015
149MP0006292_abnormal_olfactory_placode0.65035225
150MP0002697_abnormal_eye_size0.64482046
151MP0005075_abnormal_melanosome_morpholog0.64057491
152MP0003329_amyloid_beta_deposits0.64017224
153MP0005248_abnormal_Harderian_gland0.62332003
154MP0008873_increased_physiological_sensi0.62093499
155MP0005187_abnormal_penis_morphology0.62013476
156MP0003878_abnormal_ear_physiology0.61604340
157MP0005377_hearing/vestibular/ear_phenot0.61604340
158MP0008874_decreased_physiological_sensi0.60348385
159MP0001324_abnormal_eye_pigmentation0.60137617
160MP0001986_abnormal_taste_sensitivity0.60000236
161MP0000653_abnormal_sex_gland0.59799802
162MP0004233_abnormal_muscle_weight0.59759690
163MP0000534_abnormal_ureter_morphology0.59007415
164MP0002938_white_spotting0.58537180
165MP0006035_abnormal_mitochondrial_morpho0.58484742
166MP0001501_abnormal_sleep_pattern0.56518310
167MP0004019_abnormal_vitamin_homeostasis0.55480609
168MP0000026_abnormal_inner_ear0.55126278
169MP0001270_distended_abdomen0.54632316
170MP0004085_abnormal_heartbeat0.54292701
171MP0003633_abnormal_nervous_system0.53337654
172MP0002837_dystrophic_cardiac_calcinosis0.51990035
173MP0003698_abnormal_male_reproductive0.50479657
174MP0010234_abnormal_vibrissa_follicle0.49867889

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.74607245
2Abnormality of macular pigmentation (HP:0008002)7.33337470
3Retinal dysplasia (HP:0007973)6.43939244
4Myokymia (HP:0002411)5.39550555
5Abnormal respiratory motile cilium physiology (HP:0012261)4.86273469
6Chronic bronchitis (HP:0004469)4.58611726
7Congenital stationary night blindness (HP:0007642)4.51426617
8Limb dystonia (HP:0002451)4.43905238
9Bifid tongue (HP:0010297)4.38671898
10Bony spicule pigmentary retinopathy (HP:0007737)4.36309105
11Rhinitis (HP:0012384)4.23187507
12Abnormality of midbrain morphology (HP:0002418)4.20633343
13Molar tooth sign on MRI (HP:0002419)4.20633343
14Atonic seizures (HP:0010819)4.17572813
15Gait imbalance (HP:0002141)4.12015871
16Congenital primary aphakia (HP:0007707)4.01610243
17Febrile seizures (HP:0002373)4.00623568
18Abnormality of the labia minora (HP:0012880)3.98092592
19Central scotoma (HP:0000603)3.93135623
20Medial flaring of the eyebrow (HP:0010747)3.83126986
21Increased hepatocellular lipid droplets (HP:0006565)3.82076864
22Absence seizures (HP:0002121)3.80720220
23Nephrogenic diabetes insipidus (HP:0009806)3.72748463
24Palpitations (HP:0001962)3.64432653
25Abolished electroretinogram (ERG) (HP:0000550)3.63672988
26Abnormal rod and cone electroretinograms (HP:0008323)3.45193184
27Lipid accumulation in hepatocytes (HP:0006561)3.43266876
28Torticollis (HP:0000473)3.37922736
29Birth length less than 3rd percentile (HP:0003561)3.34668611
30Meckel diverticulum (HP:0002245)3.32656157
31Abnormal ciliary motility (HP:0012262)3.26409315
32Severe visual impairment (HP:0001141)3.26094941
33Dialeptic seizures (HP:0011146)3.22024343
34Vaginal atresia (HP:0000148)3.18876585
35Abnormality of the ileum (HP:0001549)3.18748898
36Genital tract atresia (HP:0001827)3.15824345
37Reticulocytopenia (HP:0001896)3.13139941
38Sensory axonal neuropathy (HP:0003390)3.12004348
39Syncope (HP:0001279)3.09296460
40Poor coordination (HP:0002370)3.07857784
41Chromsome breakage (HP:0040012)3.04794972
42Chromosomal breakage induced by crosslinking agents (HP:0003221)3.03500227
43Epileptic encephalopathy (HP:0200134)2.99009281
44Abnormality of chromosome stability (HP:0003220)2.96026298
45Cholecystitis (HP:0001082)2.94879073
46Abnormal gallbladder physiology (HP:0012438)2.94879073
47Pancreatic fibrosis (HP:0100732)2.92172008
48True hermaphroditism (HP:0010459)2.90261598
49Absent radius (HP:0003974)2.88284436
50Craniofacial dystonia (HP:0012179)2.87357917
51Abnormal lung lobation (HP:0002101)2.87337457
52Dysphonia (HP:0001618)2.85526873
53Anosmia (HP:0000458)2.84294303
54Abnormal respiratory epithelium morphology (HP:0012253)2.82452636
55Abnormal respiratory motile cilium morphology (HP:0005938)2.82452636
56Hypothermia (HP:0002045)2.82267722
57Mitochondrial inheritance (HP:0001427)2.79751890
58Aqueductal stenosis (HP:0002410)2.79658619
59Renal Fanconi syndrome (HP:0001994)2.78444368
60Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.77124070
61Respiratory difficulties (HP:0002880)2.76740379
62Colon cancer (HP:0003003)2.75740306
63Abnormality of the preputium (HP:0100587)2.72668187
64Postaxial hand polydactyly (HP:0001162)2.71572538
65Absent septum pellucidum (HP:0001331)2.70813726
66Aplasia/Hypoplasia of the uvula (HP:0010293)2.67693743
67Multiple enchondromatosis (HP:0005701)2.67618069
68Aplasia involving forearm bones (HP:0009822)2.66735464
69Absent forearm bone (HP:0003953)2.66735464
70Focal seizures (HP:0007359)2.65411168
71Aplasia/Hypoplasia of the sacrum (HP:0008517)2.64991824
72Intestinal atresia (HP:0011100)2.64398700
73Focal dystonia (HP:0004373)2.60457168
74Gonadotropin excess (HP:0000837)2.59621666
75Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.59611865
76Horseshoe kidney (HP:0000085)2.59341318
77Microvesicular hepatic steatosis (HP:0001414)2.56977793
78Myotonia (HP:0002486)2.54148663
79Exertional dyspnea (HP:0002875)2.49211665
80Reduced antithrombin III activity (HP:0001976)2.48424028
81Maternal diabetes (HP:0009800)2.46591231
82Absent thumb (HP:0009777)2.44435517
83Aplastic anemia (HP:0001915)2.43512499
84Aplasia/Hypoplasia of the lens (HP:0008063)2.43336202
85Increased CSF lactate (HP:0002490)2.43313372
86Hyperalaninemia (HP:0003348)2.43173565
87Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.43173565
88Abnormality of alanine metabolism (HP:0010916)2.43173565
89Dynein arm defect of respiratory motile cilia (HP:0012255)2.38867659
90Absent/shortened dynein arms (HP:0200106)2.38867659
91Hyperinsulinemic hypoglycemia (HP:0000825)2.37178461
92Prolonged QT interval (HP:0001657)2.35647261
93Absent rod-and cone-mediated responses on ERG (HP:0007688)2.35495531
94Scotoma (HP:0000575)2.33281922
95Increased intramyocellular lipid droplets (HP:0012240)2.31516351
96Abnormality of the septum pellucidum (HP:0007375)2.31192724
97Cerebral edema (HP:0002181)2.30129681
98Abnormal number of erythroid precursors (HP:0012131)2.29862092
99Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.29455215
100Retinitis pigmentosa (HP:0000510)2.29420340
101Generalized tonic-clonic seizures (HP:0002069)2.29364613
102Optic nerve hypoplasia (HP:0000609)2.29143319
103Abnormality of the duodenum (HP:0002246)2.28529866
104Embryonal renal neoplasm (HP:0011794)2.26945240
105Abnormality of serum amino acid levels (HP:0003112)2.26867164
106Choanal stenosis (HP:0000452)2.23887770
107Pancreatic cysts (HP:0001737)2.22877888
108Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.22755056
109Decreased activity of mitochondrial respiratory chain (HP:0008972)2.22755056
110Cleft eyelid (HP:0000625)2.22688080
111Cerebral hypomyelination (HP:0006808)2.22525919
112Nephroblastoma (Wilms tumor) (HP:0002667)2.22026255
113Neuroendocrine neoplasm (HP:0100634)2.20806488
114Hyperglycinemia (HP:0002154)2.20679203
115Carpal bone hypoplasia (HP:0001498)2.20527570
116Triphalangeal thumb (HP:0001199)2.19860369
117Occipital encephalocele (HP:0002085)2.18890434
118Termporal pattern (HP:0011008)2.18697785
119Insidious onset (HP:0003587)2.18697785
120Constricted visual fields (HP:0001133)2.18442435
121Abnormality of the parathyroid morphology (HP:0011766)2.15078104
122Abnormality of cells of the erythroid lineage (HP:0012130)2.12381674
123Hypoplasia of the pons (HP:0012110)2.12181973
124Abnormality of glycine metabolism (HP:0010895)2.10779810
125Abnormality of serine family amino acid metabolism (HP:0010894)2.10779810
126Type I transferrin isoform profile (HP:0003642)2.09993516
127Visual hallucinations (HP:0002367)2.09496547
128Decreased central vision (HP:0007663)2.06786267
129Cellular immunodeficiency (HP:0005374)2.06566209
130Nephronophthisis (HP:0000090)2.05894577
131Esophageal atresia (HP:0002032)2.03865686
132Ventricular fibrillation (HP:0001663)2.03417315
133Increased muscle lipid content (HP:0009058)2.02934083
134Abnormality of methionine metabolism (HP:0010901)2.01721885
135Hyperglycinuria (HP:0003108)2.00961950
136Duodenal stenosis (HP:0100867)2.00902389
137Small intestinal stenosis (HP:0012848)2.00902389
138Progressive external ophthalmoplegia (HP:0000590)1.99098709
139Hepatocellular necrosis (HP:0001404)1.98721764
140Increased corneal curvature (HP:0100692)1.98203379
141Keratoconus (HP:0000563)1.98203379
142Acute necrotizing encephalopathy (HP:0006965)1.98097981
143Macrocytic anemia (HP:0001972)1.96624422
144Myelodysplasia (HP:0002863)1.96378734
145Left ventricular hypertrophy (HP:0001712)1.96338659
146Action tremor (HP:0002345)1.96266670
147Abnormality of renal resorption (HP:0011038)1.95270712
148Bronchiectasis (HP:0002110)1.94883011
149Focal motor seizures (HP:0011153)1.93945000
150Progressive macrocephaly (HP:0004481)1.93212021
151Breast aplasia (HP:0100783)1.92982490
152Exercise intolerance (HP:0003546)1.92903132
153Broad foot (HP:0001769)1.92230700
154Tracheoesophageal fistula (HP:0002575)1.91331374
155Sclerocornea (HP:0000647)1.90434525
156Supranuclear gaze palsy (HP:0000605)1.89868477
157Increased serum lactate (HP:0002151)1.89793274
158Abnormality of the pons (HP:0007361)1.89487535
159Congenital malformation of the right heart (HP:0011723)1.89422961
160Double outlet right ventricle (HP:0001719)1.89422961
161Specific learning disability (HP:0001328)1.88856557
162Lactic acidosis (HP:0003128)1.88126839
163Hypoglycemic seizures (HP:0002173)1.88067692
164Stenosis of the external auditory canal (HP:0000402)1.87673843
165Pallor (HP:0000980)1.87179653
166Renal hypoplasia (HP:0000089)1.87152507
167Hypoplastic pelvis (HP:0008839)1.86768553
168Hemivertebrae (HP:0002937)1.85470374
169Oral leukoplakia (HP:0002745)1.85301122
170Rectovaginal fistula (HP:0000143)1.84574120
171Rectal fistula (HP:0100590)1.84574120
172Postnatal microcephaly (HP:0005484)1.83129343
173Narrow forehead (HP:0000341)1.82773534
174Chronic hepatic failure (HP:0100626)1.82266659
175Aplasia/Hypoplasia of the tongue (HP:0010295)1.82051182
176Acute lymphatic leukemia (HP:0006721)1.82006828
177Abnormal protein N-linked glycosylation (HP:0012347)1.81696434
178Abnormal protein glycosylation (HP:0012346)1.81696434
179Abnormal glycosylation (HP:0012345)1.81696434
180Supernumerary spleens (HP:0009799)1.79949924
181Acute encephalopathy (HP:0006846)1.79680272
182Abnormality of the vocal cords (HP:0008777)1.79260385
183Oculomotor apraxia (HP:0000657)1.78648297
184Adrenal hypoplasia (HP:0000835)1.78646416
185Decreased testicular size (HP:0008734)1.77383295
186Cystic liver disease (HP:0006706)1.76856024
187Abnormal mitochondria in muscle tissue (HP:0008316)1.76054532
188Aganglionic megacolon (HP:0002251)1.74567744
189Sudden death (HP:0001699)1.74168707
190Abnormality of the fovea (HP:0000493)1.73776235
191Septo-optic dysplasia (HP:0100842)1.71991205
192Delusions (HP:0000746)1.71561762
193Abnormal hair whorl (HP:0010721)1.71161578
194Optic disc pallor (HP:0000543)1.71075985

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.45170335
2ARAF4.08522781
3ZAK3.42024411
4STK38L3.40716699
5CDC73.38726182
6PHKG13.01887557
7PHKG23.01887557
8CAMK2D2.81514603
9MST42.79597853
10VRK22.75668247
11PAK32.71017699
12TRIM282.63698335
13MKNK22.48917168
14TNIK2.47446860
15KSR22.41805018
16GRK52.39692748
17CAMK2B2.32258925
18BRSK22.31114338
19NME22.24156151
20PLK32.13868414
21SRPK12.13129037
22CAMK2G2.08264266
23BRAF2.07170646
24WNK31.99957583
25TAF11.90800461
26MAP3K91.88039268
27NME11.87584652
28PAK61.87283658
29TSSK61.83521231
30MARK31.83078687
31MKNK11.78438715
32BMPR21.76597785
33DYRK31.76392842
34MOS1.75092860
35PASK1.73729817
36MAPK151.71211951
37VRK11.65823263
38DAPK21.64874444
39STK241.63423875
40CASK1.60796988
41NLK1.60045094
42CSNK1G31.59809125
43MAP3K101.57030701
44MAP2K71.56333470
45PLK11.52896251
46CSNK1A1L1.52320099
47STK381.52006415
48STK391.49886626
49MAP3K41.47879743
50ACVR1B1.45972847
51STK161.39761219
52PRPF4B1.35665120
53TTK1.34071664
54BRSK11.32598938
55CAMK2A1.31737398
56CSNK1G21.30805466
57MAPKAPK31.30624013
58NUAK11.25777738
59CDK191.24153847
60ALK1.22941364
61PRKCG1.21470066
62MINK11.19904246
63SGK2231.18711553
64SGK4941.18711553
65ERBB31.18677296
66NEK11.16506518
67TNK21.16041120
68CSNK1G11.15944824
69EIF2AK31.12391147
70NEK21.12148250
71BMPR1B1.10306383
72DYRK1A1.09644154
73STK41.08831890
74MAP3K131.05538673
75PINK11.01409969
76MAP3K61.00636018
77PAK40.99712761
78RAF10.99074256
79LATS20.94158793
80DYRK20.91750745
81WEE10.90647500
82PLK20.90040563
83ICK0.89877332
84CHEK20.89580664
85ILK0.88536410
86PNCK0.86332986
87CDK30.84315146
88MARK10.84031747
89EPHA40.83732470
90CAMKK20.82593709
91OXSR10.81045171
92IRAK20.80470795
93MUSK0.79859230
94PRKG20.79808953
95FRK0.78886608
96RIPK10.75993484
97TGFBR10.73808712
98MAPK130.72695807
99FGR0.72544329
100CAMK1G0.71788191
101BCKDK0.71691904
102CDK90.70086877
103ATR0.69854691
104CDK140.69809202
105CDK50.69383838
106MARK20.68101822
107PRKD30.66173738
108MAPKAPK50.65917488
109CHEK10.65642750
110MAP4K10.64995106
111CLK10.64788682
112ERBB40.64540419
113CDK80.64329598
114NTRK10.63211166
115PRKAA10.62248074
116HIPK20.61115511
117NTRK30.60788859
118PLK40.59927697
119MAP3K20.58598147
120ROCK20.58423984
121IRAK10.57262694
122MATK0.55908495
123PRKAA20.55855927
124STK30.54918947
125RPS6KA20.53975873
126CDK40.53935378
127SIK30.51381026
128MAP2K40.49903867
129MELK0.49501755
130DAPK10.49490149
131PRKCE0.49386790
132PKN10.48799304
133PAK10.48494916
134AKT30.48331296
135CDK180.48256984
136CDK150.48160535
137PRKD20.48154097
138PBK0.47339031
139AURKA0.46680854
140CSNK2A10.46655643
141MAPK100.46294250
142FGFR10.45470486
143PRKACA0.44677252
144MAP3K80.44497111
145WNK40.43987535
146RPS6KA40.43835274
147AURKB0.41442309
148GRK10.40590963
149DMPK0.40491208
150CAMK1D0.40466252
151ATM0.39542288
152LATS10.36937845
153SGK20.36504210
154STK110.36088938
155CDK11A0.35915246
156CDK70.35850383
157PIM20.35687749
158CSNK2A20.34509270
159TAOK10.31790735
160CDK60.31151510
161FGFR20.30934121
162DAPK30.30825036
163PIM10.29868956
164PTK60.29816866
165PRKCQ0.29206066
166CDK20.28708351
167BMX0.27976963
168PRKCI0.26909988
169CDK10.26718043
170PDK20.26473319
171MAP2K30.25564272
172EIF2AK20.25294724
173STK100.24985491
174CSNK1E0.24061304
175UHMK10.22679397
176CSK0.20800848
177RPS6KA10.20718424
178RPS6KA50.20555877

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047409.78442189
2Proteasome_Homo sapiens_hsa030503.97970997
3DNA replication_Homo sapiens_hsa030303.89964289
4Mismatch repair_Homo sapiens_hsa034303.77857820
5Ribosome_Homo sapiens_hsa030103.77524236
6RNA polymerase_Homo sapiens_hsa030203.32621679
7Homologous recombination_Homo sapiens_hsa034403.11370023
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.99756434
9Spliceosome_Homo sapiens_hsa030402.73923750
10Base excision repair_Homo sapiens_hsa034102.73758893
11Non-homologous end-joining_Homo sapiens_hsa034502.73541016
12Phototransduction_Homo sapiens_hsa047442.62306726
13Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.58198070
14Synaptic vesicle cycle_Homo sapiens_hsa047212.53603528
15Morphine addiction_Homo sapiens_hsa050322.42343184
16GABAergic synapse_Homo sapiens_hsa047272.41420165
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.21834280
18Circadian entrainment_Homo sapiens_hsa047132.20134172
19RNA transport_Homo sapiens_hsa030132.04451371
20Glutamatergic synapse_Homo sapiens_hsa047241.97344632
21Nicotine addiction_Homo sapiens_hsa050331.97120196
22Insulin secretion_Homo sapiens_hsa049111.92523375
23Fanconi anemia pathway_Homo sapiens_hsa034601.91749526
24Protein export_Homo sapiens_hsa030601.89707332
25Nucleotide excision repair_Homo sapiens_hsa034201.86660626
26RNA degradation_Homo sapiens_hsa030181.84268521
27Taste transduction_Homo sapiens_hsa047421.83228983
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.81773841
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.81292126
30Pyrimidine metabolism_Homo sapiens_hsa002401.73630955
31Oxidative phosphorylation_Homo sapiens_hsa001901.71323051
32Basal transcription factors_Homo sapiens_hsa030221.71071689
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.68404541
34Cholinergic synapse_Homo sapiens_hsa047251.67862977
35Parkinsons disease_Homo sapiens_hsa050121.67226979
36Vibrio cholerae infection_Homo sapiens_hsa051101.66699846
37Salivary secretion_Homo sapiens_hsa049701.65821002
38Dopaminergic synapse_Homo sapiens_hsa047281.65109813
39Ovarian steroidogenesis_Homo sapiens_hsa049131.64361145
40Collecting duct acid secretion_Homo sapiens_hsa049661.58189133
41Cell cycle_Homo sapiens_hsa041101.49081078
42Aldosterone synthesis and secretion_Homo sapiens_hsa049251.39310212
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.38936518
44Cardiac muscle contraction_Homo sapiens_hsa042601.36477262
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.32500724
46Glutathione metabolism_Homo sapiens_hsa004801.30143224
47Sulfur relay system_Homo sapiens_hsa041221.27534552
48Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.27118683
49cAMP signaling pathway_Homo sapiens_hsa040241.26834807
50Alzheimers disease_Homo sapiens_hsa050101.26132648
51mRNA surveillance pathway_Homo sapiens_hsa030151.26129599
52Folate biosynthesis_Homo sapiens_hsa007901.24844893
53Serotonergic synapse_Homo sapiens_hsa047261.23813346
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.21938297
55Gastric acid secretion_Homo sapiens_hsa049711.21616321
56One carbon pool by folate_Homo sapiens_hsa006701.21604622
57Selenocompound metabolism_Homo sapiens_hsa004501.21210695
58Vitamin digestion and absorption_Homo sapiens_hsa049771.19932175
59Fatty acid elongation_Homo sapiens_hsa000621.19810657
60GnRH signaling pathway_Homo sapiens_hsa049121.18422813
612-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.11089186
62Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.09729989
63Oocyte meiosis_Homo sapiens_hsa041141.07544365
64Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.07291745
65Calcium signaling pathway_Homo sapiens_hsa040201.04910857
66cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03911504
67Huntingtons disease_Homo sapiens_hsa050161.03858104
68Oxytocin signaling pathway_Homo sapiens_hsa049211.01743461
69Circadian rhythm_Homo sapiens_hsa047100.97354371
70Renin secretion_Homo sapiens_hsa049240.97146047
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.96960914
72Sphingolipid metabolism_Homo sapiens_hsa006000.94837107
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.94045113
74Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.92261078
75Biosynthesis of amino acids_Homo sapiens_hsa012300.91900770
76Alcoholism_Homo sapiens_hsa050340.91495139
77Bile secretion_Homo sapiens_hsa049760.90478247
78Gap junction_Homo sapiens_hsa045400.89137654
79Nitrogen metabolism_Homo sapiens_hsa009100.88068185
80Estrogen signaling pathway_Homo sapiens_hsa049150.82625590
81Long-term potentiation_Homo sapiens_hsa047200.80776498
82Amphetamine addiction_Homo sapiens_hsa050310.80150595
83Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.79477031
84Thyroid hormone synthesis_Homo sapiens_hsa049180.77766432
85Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.77484332
86Fatty acid biosynthesis_Homo sapiens_hsa000610.75394233
87Carbon metabolism_Homo sapiens_hsa012000.74605863
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72320465
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69843913
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65884024
91Melanogenesis_Homo sapiens_hsa049160.65694172
92Purine metabolism_Homo sapiens_hsa002300.65650909
93Dilated cardiomyopathy_Homo sapiens_hsa054140.64212921
94Propanoate metabolism_Homo sapiens_hsa006400.61934016
95Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.60723108
96Pancreatic secretion_Homo sapiens_hsa049720.60168743
97Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.59453357
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58715013
99Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55978248
100p53 signaling pathway_Homo sapiens_hsa041150.53689175
101Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53059742
102Peroxisome_Homo sapiens_hsa041460.52708422
103Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51275261
104Pyruvate metabolism_Homo sapiens_hsa006200.50785760
105Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50407088
106Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49766404
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49489344
108Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48374277
109Ras signaling pathway_Homo sapiens_hsa040140.46311878
110Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46232372
111Epstein-Barr virus infection_Homo sapiens_hsa051690.45403710
112Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.45168614
113Regulation of autophagy_Homo sapiens_hsa041400.44952811
114Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44108104
115Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.42128364
116Cocaine addiction_Homo sapiens_hsa050300.41956888
117Ether lipid metabolism_Homo sapiens_hsa005650.40399194
118Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.39756454
119Basal cell carcinoma_Homo sapiens_hsa052170.39244436
120Histidine metabolism_Homo sapiens_hsa003400.37820529
121Glucagon signaling pathway_Homo sapiens_hsa049220.37808865
122Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.37430741
123Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.37245477
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.36670090
125Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35869117
126Wnt signaling pathway_Homo sapiens_hsa043100.35392761
127Mineral absorption_Homo sapiens_hsa049780.35184451
128Glycerophospholipid metabolism_Homo sapiens_hsa005640.34871712
129Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.33602442
130SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32853244
131Glioma_Homo sapiens_hsa052140.31907204
132Drug metabolism - other enzymes_Homo sapiens_hsa009830.31523332
133Arginine and proline metabolism_Homo sapiens_hsa003300.31446389
134Galactose metabolism_Homo sapiens_hsa000520.31339977
135Dorso-ventral axis formation_Homo sapiens_hsa043200.30487757
136Axon guidance_Homo sapiens_hsa043600.29839357
137Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.28759694
138Rap1 signaling pathway_Homo sapiens_hsa040150.28200436
139Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.27285706
140Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26970830
141Chemical carcinogenesis_Homo sapiens_hsa052040.26673130
142Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.26236264
143Steroid biosynthesis_Homo sapiens_hsa001000.24436199
144TGF-beta signaling pathway_Homo sapiens_hsa043500.24389547
145N-Glycan biosynthesis_Homo sapiens_hsa005100.21553169
146Rheumatoid arthritis_Homo sapiens_hsa053230.20314501
147Melanoma_Homo sapiens_hsa052180.20288807
148Long-term depression_Homo sapiens_hsa047300.19780601
149Fat digestion and absorption_Homo sapiens_hsa049750.19222321
150Insulin signaling pathway_Homo sapiens_hsa049100.18816622
151Fatty acid metabolism_Homo sapiens_hsa012120.17369568
152Hedgehog signaling pathway_Homo sapiens_hsa043400.16650628
153Fatty acid degradation_Homo sapiens_hsa000710.15956368
154Vitamin B6 metabolism_Homo sapiens_hsa007500.14358484
155Sphingolipid signaling pathway_Homo sapiens_hsa040710.13289945
156Carbohydrate digestion and absorption_Homo sapiens_hsa049730.13237911
157Arachidonic acid metabolism_Homo sapiens_hsa005900.13109629
158Metabolic pathways_Homo sapiens_hsa011000.12446898
159Renal cell carcinoma_Homo sapiens_hsa052110.12065947
160Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.11788122
161Chemokine signaling pathway_Homo sapiens_hsa040620.11103069
162Inositol phosphate metabolism_Homo sapiens_hsa005620.11047832
163beta-Alanine metabolism_Homo sapiens_hsa004100.10511813
164Linoleic acid metabolism_Homo sapiens_hsa005910.08758056
165Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.08462418
166Hippo signaling pathway_Homo sapiens_hsa043900.08299242
167Pancreatic cancer_Homo sapiens_hsa052120.07956943
168Arginine biosynthesis_Homo sapiens_hsa002200.02393973
169Pentose and glucuronate interconversions_Homo sapiens_hsa000400.01778918
170Butanoate metabolism_Homo sapiens_hsa00650-0.0010168

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »