NRN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the neuritin family, and is expressed in postmitotic-differentiating neurons of the developmental nervous system and neuronal structures associated with plasticity in the adult. The expression of this gene can be induced by neural activity and neurotrophins. The encoded protein contains a consensus cleavage signal found in glycosylphoshatidylinositol (GPI)-anchored proteins. The encoded protein promotes neurite outgrowth and arborization, suggesting its role in promoting neuritogenesis. Overexpression of the encoded protein may be associated with astrocytoma progression. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)7.21018703
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.46663285
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.06081839
4L-phenylalanine catabolic process (GO:0006559)6.06081839
5regulation of synaptic vesicle exocytosis (GO:2000300)5.80709055
6L-phenylalanine metabolic process (GO:0006558)5.74299836
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.74299836
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.50539457
9aromatic amino acid family catabolic process (GO:0009074)5.36093300
10membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.21290076
11regulation of synaptic vesicle transport (GO:1902803)5.13073641
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.09068003
13cellular potassium ion homeostasis (GO:0030007)4.88308772
14bile acid biosynthetic process (GO:0006699)4.87741914
15neurotransmitter secretion (GO:0007269)4.82822690
16positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.78141037
17postsynaptic membrane organization (GO:0001941)4.74488444
18locomotory exploration behavior (GO:0035641)4.73108259
19kynurenine metabolic process (GO:0070189)4.72604734
20tryptophan catabolic process (GO:0006569)4.71575468
21indole-containing compound catabolic process (GO:0042436)4.71575468
22indolalkylamine catabolic process (GO:0046218)4.71575468
23high-density lipoprotein particle remodeling (GO:0034375)4.71511227
24vocalization behavior (GO:0071625)4.67612607
25cerebellar granule cell differentiation (GO:0021707)4.56045200
26negative regulation of fibrinolysis (GO:0051918)4.54181166
27ionotropic glutamate receptor signaling pathway (GO:0035235)4.53324755
28protein localization to synapse (GO:0035418)4.50513423
29regulation of neuronal synaptic plasticity (GO:0048168)4.47045658
30regulation of fibrinolysis (GO:0051917)4.43614801
31sodium ion export (GO:0071436)4.42745535
32urea metabolic process (GO:0019627)4.38656252
33urea cycle (GO:0000050)4.38656252
34tryptophan metabolic process (GO:0006568)4.36062984
35positive regulation of synapse maturation (GO:0090129)4.34383086
36glyoxylate metabolic process (GO:0046487)4.33006070
37regulation of synapse structural plasticity (GO:0051823)4.30930380
38dendritic spine morphogenesis (GO:0060997)4.30187637
39alpha-linolenic acid metabolic process (GO:0036109)4.27467390
40regulation of protein activation cascade (GO:2000257)4.25646095
41regulation of glutamate receptor signaling pathway (GO:1900449)4.20008640
42neuronal action potential propagation (GO:0019227)4.17740706
43protein carboxylation (GO:0018214)4.16691542
44peptidyl-glutamic acid carboxylation (GO:0017187)4.16691542
45exploration behavior (GO:0035640)4.14485691
46synaptic transmission, glutamatergic (GO:0035249)4.14139193
47regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.13205682
48bile acid metabolic process (GO:0008206)4.09828324
49complement activation, alternative pathway (GO:0006957)4.09354418
50neuronal ion channel clustering (GO:0045161)4.04548139
51regulation of long-term neuronal synaptic plasticity (GO:0048169)4.04314600
52cell migration in hindbrain (GO:0021535)4.04024486
53nitrogen cycle metabolic process (GO:0071941)4.03786173
54cellular ketone body metabolic process (GO:0046950)4.02935013
55reverse cholesterol transport (GO:0043691)4.02780066
56positive regulation of dendritic spine development (GO:0060999)3.99529599
57regulation of complement activation (GO:0030449)3.96068770
58coenzyme catabolic process (GO:0009109)3.95190592
59dicarboxylic acid biosynthetic process (GO:0043650)3.95005498
60cysteine metabolic process (GO:0006534)3.94460820
61sulfur amino acid catabolic process (GO:0000098)3.93938189
62macromolecular complex remodeling (GO:0034367)3.93893413
63plasma lipoprotein particle remodeling (GO:0034369)3.93893413
64protein-lipid complex remodeling (GO:0034368)3.93893413
65regulation of cholesterol esterification (GO:0010872)3.93693124
66negative regulation of synaptic transmission, GABAergic (GO:0032229)3.90456875
67neuron cell-cell adhesion (GO:0007158)3.88033826
68glutamate receptor signaling pathway (GO:0007215)3.87676728
69neurotransmitter transport (GO:0006836)3.85874046
70aromatic amino acid family metabolic process (GO:0009072)3.84544415
71tyrosine metabolic process (GO:0006570)3.83300482
72auditory behavior (GO:0031223)3.81754049
73regulation of voltage-gated calcium channel activity (GO:1901385)3.79735283
74positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.77880791
75positive regulation of membrane potential (GO:0045838)3.77129615
76serine family amino acid catabolic process (GO:0009071)3.76331965
77neuron-neuron synaptic transmission (GO:0007270)3.75635981
78synaptic vesicle endocytosis (GO:0048488)3.74972265
79regulation of excitatory postsynaptic membrane potential (GO:0060079)3.74883624
80regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.74314039
81regulation of neurotransmitter secretion (GO:0046928)3.73160363
82negative regulation of cholesterol transport (GO:0032375)3.67455913
83negative regulation of sterol transport (GO:0032372)3.67455913
84cerebellar Purkinje cell differentiation (GO:0021702)3.67177067
85layer formation in cerebral cortex (GO:0021819)3.66513952
86positive regulation of dendritic spine morphogenesis (GO:0061003)3.65567594
87glutamate metabolic process (GO:0006536)3.62442324
88glutamate secretion (GO:0014047)3.61086990
89phospholipid efflux (GO:0033700)3.60696830
90regulation of synapse maturation (GO:0090128)3.60475693
91alpha-amino acid catabolic process (GO:1901606)3.59713320
92gamma-aminobutyric acid signaling pathway (GO:0007214)3.58165883
93triglyceride homeostasis (GO:0070328)3.57815959
94acylglycerol homeostasis (GO:0055090)3.57815959
95cholesterol efflux (GO:0033344)3.56283780
96positive regulation of neurotransmitter transport (GO:0051590)3.55400925
97regulation of vesicle fusion (GO:0031338)3.53381077
98cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.53361914
99regulation of triglyceride catabolic process (GO:0010896)3.52520645
100membrane depolarization during action potential (GO:0086010)3.52287958
101regulation of postsynaptic membrane potential (GO:0060078)3.52064723
102lysine metabolic process (GO:0006553)3.51248751
103lysine catabolic process (GO:0006554)3.51248751
104fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.51125753
105L-amino acid import (GO:0043092)3.50505042
106regulation of neurotransmitter levels (GO:0001505)3.50203267
107neuromuscular synaptic transmission (GO:0007274)3.48852726
108ketone body metabolic process (GO:1902224)3.47166456
109regulation of neurotransmitter transport (GO:0051588)3.44675165
110neuromuscular process controlling balance (GO:0050885)3.43669030
111negative regulation of protein activation cascade (GO:2000258)3.43421792
112bile acid and bile salt transport (GO:0015721)3.42963780
113presynaptic membrane organization (GO:0097090)3.41812093
114gamma-aminobutyric acid transport (GO:0015812)3.40826319
115homocysteine metabolic process (GO:0050667)3.38834602
116amino-acid betaine metabolic process (GO:0006577)3.38714488
117axonal fasciculation (GO:0007413)3.37404022
118regulation of dendritic spine morphogenesis (GO:0061001)3.36654220
119regulation of synaptic plasticity (GO:0048167)3.36188762
120neuron recognition (GO:0008038)3.35413477
121membrane depolarization (GO:0051899)3.33368131
122presynaptic membrane assembly (GO:0097105)3.33315486
123regulation of synaptic transmission, glutamatergic (GO:0051966)3.32629358
124drug catabolic process (GO:0042737)3.30965113
125transmission of nerve impulse (GO:0019226)3.30353666
126benzene-containing compound metabolic process (GO:0042537)3.30334552
127positive regulation of neurotransmitter secretion (GO:0001956)3.29333871
128low-density lipoprotein particle remodeling (GO:0034374)3.29139982
129long-term memory (GO:0007616)3.28876935
130cellular amino acid catabolic process (GO:0009063)3.28651630
131cellular modified amino acid catabolic process (GO:0042219)3.28514936
132potassium ion homeostasis (GO:0055075)3.28275581
133indolalkylamine metabolic process (GO:0006586)3.27522728
134cellular glucuronidation (GO:0052695)3.25791489
135dendritic spine organization (GO:0097061)3.24815184
136plasma lipoprotein particle clearance (GO:0034381)3.23658401
137imidazole-containing compound metabolic process (GO:0052803)3.22802927
138cell differentiation in hindbrain (GO:0021533)3.21855829
139cofactor catabolic process (GO:0051187)3.20849107
140amine catabolic process (GO:0009310)3.20570510
141cellular biogenic amine catabolic process (GO:0042402)3.20570510
142negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.20148725
143regulation of dendritic spine development (GO:0060998)3.19991959
144negative regulation of dendrite morphogenesis (GO:0050774)3.18399760
145regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.17305922
146potassium ion import (GO:0010107)3.16723198
147fibrinolysis (GO:0042730)3.13497934
148arginine metabolic process (GO:0006525)3.12444103
149amino acid import (GO:0043090)3.12413172
150response to auditory stimulus (GO:0010996)3.12318838
151cell communication by electrical coupling (GO:0010644)3.11680067
152neurotransmitter-gated ion channel clustering (GO:0072578)3.10683459
153synaptic vesicle docking involved in exocytosis (GO:0016081)3.10603047
154aldehyde catabolic process (GO:0046185)3.10415513
155axon ensheathment in central nervous system (GO:0032291)3.09432262
156central nervous system myelination (GO:0022010)3.09432262
157positive regulation of lipid catabolic process (GO:0050996)3.04900558
158G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.04495715
159regulation of bile acid biosynthetic process (GO:0070857)3.03038261
160adult walking behavior (GO:0007628)3.00810564
161regulation of synaptic transmission (GO:0050804)2.99979731
162cytolysis (GO:0019835)2.99731576
163pyrimidine nucleobase catabolic process (GO:0006208)2.99171709
164blood coagulation, intrinsic pathway (GO:0007597)2.98981117
165negative regulation of lipase activity (GO:0060192)2.98189454
166proline transport (GO:0015824)2.97607665
167mating behavior (GO:0007617)2.97296700
168synaptic transmission (GO:0007268)2.97179486
169indole-containing compound metabolic process (GO:0042430)2.97014098
170plasma lipoprotein particle assembly (GO:0034377)2.96521893
171complement activation, classical pathway (GO:0006958)2.95722076
172exogenous drug catabolic process (GO:0042738)2.95615395
173glucuronate metabolic process (GO:0019585)2.95596269
174uronic acid metabolic process (GO:0006063)2.95596269
175opsonization (GO:0008228)2.92908919
176mechanosensory behavior (GO:0007638)2.91218609
177synaptic vesicle transport (GO:0048489)2.90057095
178establishment of synaptic vesicle localization (GO:0097480)2.90057095
179neuromuscular process (GO:0050905)2.89866852
180cellular sodium ion homeostasis (GO:0006883)2.89412639
181ethanol oxidation (GO:0006069)2.88920846
182establishment of mitochondrion localization (GO:0051654)2.88792386
183complement activation (GO:0006956)2.88504251
184acetyl-CoA metabolic process (GO:0006084)2.87421196
185aspartate family amino acid catabolic process (GO:0009068)2.86897044
186protein activation cascade (GO:0072376)2.86395823
187phospholipid homeostasis (GO:0055091)2.85894006
188synaptic vesicle exocytosis (GO:0016079)2.84658536
189short-chain fatty acid metabolic process (GO:0046459)2.84654823
190plasma lipoprotein particle organization (GO:0071827)2.84169130
191dendrite morphogenesis (GO:0048813)2.81962030
192steroid catabolic process (GO:0006706)2.80723116
193regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.79970097
194negative regulation of complement activation (GO:0045916)2.79901955
195organic acid catabolic process (GO:0016054)2.79739204

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.84520735
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.72532924
3PPARA_22158963_ChIP-Seq_LIVER_Mouse3.77290509
4LXR_22158963_ChIP-Seq_LIVER_Mouse3.68696741
5EGR1_23403033_ChIP-Seq_LIVER_Mouse3.58367017
6* FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.31932519
7EZH2_22144423_ChIP-Seq_EOC_Human3.16899983
8GBX2_23144817_ChIP-Seq_PC3_Human3.12435083
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.61775433
10TAF15_26573619_Chip-Seq_HEK293_Human2.47891765
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.36755944
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.25668912
13EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.22575617
14NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.21607925
15* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.16314213
16* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.14811476
17* CBX2_27304074_Chip-Seq_ESCs_Mouse1.92956299
18JARID2_20064375_ChIP-Seq_MESCs_Mouse1.87710248
19* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.84208153
20REST_21632747_ChIP-Seq_MESCs_Mouse1.83376187
21* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.78751126
22* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.76081727
23* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.76081727
24* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.75038463
25RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.73985552
26* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.73005342
27* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.72990245
28CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.72613427
29* EED_16625203_ChIP-ChIP_MESCs_Mouse1.64211541
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.63092071
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.62890673
32* RING1B_27294783_Chip-Seq_ESCs_Mouse1.62719159
33RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.60721492
34* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.60454446
35* RNF2_27304074_Chip-Seq_NSC_Mouse1.59309802
36REST_18959480_ChIP-ChIP_MESCs_Mouse1.57545656
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.52683879
38ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.47837678
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.47199565
40ZFP281_18757296_ChIP-ChIP_E14_Mouse1.44350958
41* TP53_20018659_ChIP-ChIP_R1E_Mouse1.43007241
42RARB_27405468_Chip-Seq_BRAIN_Mouse1.40625268
43MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.39135353
44HTT_18923047_ChIP-ChIP_STHdh_Human1.38132168
45* EZH2_27304074_Chip-Seq_ESCs_Mouse1.37638187
46P300_19829295_ChIP-Seq_ESCs_Human1.37237706
47* SMAD4_21799915_ChIP-Seq_A2780_Human1.36414011
48* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.36164448
49* EZH2_27294783_Chip-Seq_ESCs_Mouse1.35962379
50* RING1B_27294783_Chip-Seq_NPCs_Mouse1.34862298
51ZFP57_27257070_Chip-Seq_ESCs_Mouse1.33102686
52PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.33042112
53* KDM2B_26808549_Chip-Seq_K562_Human1.31135821
54TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.25419785
55OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.24298914
56AR_21572438_ChIP-Seq_LNCaP_Human1.24249570
57DROSHA_22980978_ChIP-Seq_HELA_Human1.23545647
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.22520709
59* ERG_21242973_ChIP-ChIP_JURKAT_Human1.21583895
60NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21061837
61CTCF_27219007_Chip-Seq_Bcells_Human1.21003852
62SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19844729
63ZFP281_27345836_Chip-Seq_ESCs_Mouse1.18616986
64WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17695488
65WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.17401987
66PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15366064
67* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.13104754
68ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.13003828
69* RNF2_27304074_Chip-Seq_ESCs_Mouse1.12693931
70VDR_22108803_ChIP-Seq_LS180_Human1.11517481
71NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11161437
72NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11161437
73SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10988190
74GATA1_26923725_Chip-Seq_HPCs_Mouse1.09670945
75BCAT_22108803_ChIP-Seq_LS180_Human1.08905065
76EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.08225144
77FOXA2_19822575_ChIP-Seq_HepG2_Human1.07862584
78SOX2_21211035_ChIP-Seq_LN229_Gbm1.06175572
79AR_25329375_ChIP-Seq_VCAP_Human1.06054406
80AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03694516
81MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01977998
82TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00509735
83SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.99486033
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99064653
85CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.98930655
86SMAD3_21741376_ChIP-Seq_EPCs_Human0.97746341
87SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96898161
88TET1_21490601_ChIP-Seq_MESCs_Mouse0.95907154
89POU3F2_20337985_ChIP-ChIP_501MEL_Human0.93968424
90YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92710351
91PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.90442962
92OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90391851
93BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90294166
94STAT3_23295773_ChIP-Seq_U87_Human0.89343043
95TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87317425
96* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87162375
97TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.86876466
98ARNT_22903824_ChIP-Seq_MCF-7_Human0.86349597
99TP53_18474530_ChIP-ChIP_U2OS_Human0.86088607
100* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.85664951
101ZNF217_24962896_ChIP-Seq_MCF-7_Human0.84988682
102* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84721979
103* POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.84721979
104ESR1_15608294_ChIP-ChIP_MCF-7_Human0.83974939
105BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.83766642
106AHR_22903824_ChIP-Seq_MCF-7_Human0.83399708
107SMAD3_21741376_ChIP-Seq_ESCs_Human0.83071354
108KDM2B_26808549_Chip-Seq_REH_Human0.81566165
109* DNAJC2_21179169_ChIP-ChIP_NT2_Human0.81229268
110SMAD4_21741376_ChIP-Seq_EPCs_Human0.80617809
111CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.80533006
112EGR1_19032775_ChIP-ChIP_M12_Human0.80078301
113AR_19668381_ChIP-Seq_PC3_Human0.80077526
114GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80019508
115SMAD4_21741376_ChIP-Seq_HESCs_Human0.79778021
116CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79487008
117* BMI1_23680149_ChIP-Seq_NPCS_Mouse0.79445526
118TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.78595720
119* PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.78552542
120HNF4A_19822575_ChIP-Seq_HepG2_Human0.78157811
121* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77737639
122JUN_21703547_ChIP-Seq_K562_Human0.77292311
123ZNF274_21170338_ChIP-Seq_K562_Hela0.76573357
124* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.76471333
125SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.76467827
126P53_22127205_ChIP-Seq_FIBROBLAST_Human0.75154104
127CBP_20019798_ChIP-Seq_JUKART_Human0.75003014
128IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.75003014
129IKZF1_21737484_ChIP-ChIP_HCT116_Human0.74535312
130CDX2_19796622_ChIP-Seq_MESCs_Mouse0.74508482
131TCF4_23295773_ChIP-Seq_U87_Human0.74278706
132MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.74210077
133* SOX9_26525672_Chip-Seq_HEART_Mouse0.74042883
134OCT4_19829295_ChIP-Seq_ESCs_Human0.73670634
135* RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.73546380
136KLF5_20875108_ChIP-Seq_MESCs_Mouse0.72553303
137* PRDM14_20953172_ChIP-Seq_ESCs_Human0.72063134
138* RUNX2_22187159_ChIP-Seq_PCA_Human0.71953358
139RXR_22108803_ChIP-Seq_LS180_Human0.71870257
140ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.71270207
141GATA1_22025678_ChIP-Seq_K562_Human0.70821312
142CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.70522463
143DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.70119963

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.50439128
2MP0005360_urolithiasis5.79131741
3MP0005085_abnormal_gallbladder_physiolo5.05998570
4MP0005365_abnormal_bile_salt4.66822235
5MP0008875_abnormal_xenobiotic_pharmacok4.25495761
6MP0003880_abnormal_central_pattern3.57367693
7MP0004859_abnormal_synaptic_plasticity3.31742204
8MP0010329_abnormal_lipoprotein_level2.95118236
9MP0001968_abnormal_touch/_nociception2.82440288
10MP0003806_abnormal_nucleotide_metabolis2.68330918
11MP0002736_abnormal_nociception_after2.64763641
12MP0003252_abnormal_bile_duct2.57627884
13MP0005083_abnormal_biliary_tract2.54530309
14MP0002735_abnormal_chemical_nociception2.48972864
15MP0003195_calcinosis2.40467121
16MP0004270_analgesia2.30564267
17MP0003635_abnormal_synaptic_transmissio2.13387520
18MP0005332_abnormal_amino_acid2.05116316
19MP0009840_abnormal_foam_cell1.94716355
20MP0009745_abnormal_behavioral_response1.93604146
21MP0006276_abnormal_autonomic_nervous1.82661196
22MP0002063_abnormal_learning/memory/cond1.79549862
23MP0003329_amyloid_beta_deposits1.75934714
24MP0002064_seizures1.75786873
25MP0003868_abnormal_feces_composition1.70047543
26MP0001666_abnormal_nutrient_absorption1.67206156
27MP0002118_abnormal_lipid_homeostasis1.63010293
28MP0002734_abnormal_mechanical_nocicepti1.62573660
29MP0004885_abnormal_endolymph1.57227009
30MP0002572_abnormal_emotion/affect_behav1.53097723
31MP0002876_abnormal_thyroid_physiology1.50524711
32MP0000604_amyloidosis1.50291329
33MP0002733_abnormal_thermal_nociception1.49112832
34MP0003787_abnormal_imprinting1.48478732
35MP0002272_abnormal_nervous_system1.43993915
36MP0009780_abnormal_chondrocyte_physiolo1.41454695
37MP0001440_abnormal_grooming_behavior1.41423502
38MP0009046_muscle_twitch1.40983868
39MP0002837_dystrophic_cardiac_calcinosis1.38064187
40MP0003122_maternal_imprinting1.37556224
41MP0004742_abnormal_vestibular_system1.36374715
42MP0000609_abnormal_liver_physiology1.35381651
43MP0004019_abnormal_vitamin_homeostasis1.32718330
44MP0003191_abnormal_cellular_cholesterol1.31924265
45MP0009697_abnormal_copulation1.28577017
46MP0001501_abnormal_sleep_pattern1.28457214
47MP0002067_abnormal_sensory_capabilities1.25264490
48MP0005584_abnormal_enzyme/coenzyme_acti1.23239801
49MP0001970_abnormal_pain_threshold1.23024938
50MP0001188_hyperpigmentation1.19498731
51MP0002152_abnormal_brain_morphology1.17913558
52MP0001529_abnormal_vocalization1.16336097
53MP0005319_abnormal_enzyme/_coenzyme1.16213141
54MP0002822_catalepsy1.15903342
55MP0003879_abnormal_hair_cell1.15638371
56MP0003283_abnormal_digestive_organ1.14964612
57MP0001177_atelectasis1.13488680
58MP0005535_abnormal_body_temperature1.12724846
59MP0004858_abnormal_nervous_system1.12637089
60MP0000569_abnormal_digit_pigmentation1.12480095
61MP0001764_abnormal_homeostasis1.11934181
62MP0003123_paternal_imprinting1.11033596
63MP0002638_abnormal_pupillary_reflex1.10444369
64MP0008874_decreased_physiological_sensi1.08545860
65MP0001486_abnormal_startle_reflex1.04484340
66MP0000920_abnormal_myelination1.02877925
67MP0001963_abnormal_hearing_physiology1.02323723
68MP0002138_abnormal_hepatobiliary_system1.01615021
69MP0001984_abnormal_olfaction0.99892533
70MP0003656_abnormal_erythrocyte_physiolo0.99737236
71MP0005551_abnormal_eye_electrophysiolog0.99417604
72MP0003633_abnormal_nervous_system0.96268055
73MP0008872_abnormal_physiological_respon0.94081137
74MP0002184_abnormal_innervation0.90693787
75MP0003634_abnormal_glial_cell0.87739624
76MP0005423_abnormal_somatic_nervous0.87394683
77MP0002752_abnormal_somatic_nervous0.86413040
78MP0001348_abnormal_lacrimal_gland0.85337756
79MP0004130_abnormal_muscle_cell0.84006852
80MP0005386_behavior/neurological_phenoty0.83700201
81MP0004924_abnormal_behavior0.83700201
82MP0002909_abnormal_adrenal_gland0.81884141
83MP0005646_abnormal_pituitary_gland0.81728808
84MP0005623_abnormal_meninges_morphology0.81581642
85MP0001485_abnormal_pinna_reflex0.81348008
86MP0004811_abnormal_neuron_physiology0.80993003
87MP0001346_abnormal_lacrimal_gland0.79851417
88MP0001502_abnormal_circadian_rhythm0.79138719
89MP0003632_abnormal_nervous_system0.78464821
90MP0005647_abnormal_sex_gland0.78090484
91MP0005636_abnormal_mineral_homeostasis0.77519376
92MP0005394_taste/olfaction_phenotype0.77454899
93MP0005499_abnormal_olfactory_system0.77454899
94MP0003631_nervous_system_phenotype0.77337626
95MP0005409_darkened_coat_color0.74741936
96MP0003861_abnormal_nervous_system0.74413343
97MP0002557_abnormal_social/conspecific_i0.74331635
98MP0006035_abnormal_mitochondrial_morpho0.73790478
99MP0005670_abnormal_white_adipose0.73606033
100MP0004142_abnormal_muscle_tone0.73016190
101MP0000026_abnormal_inner_ear0.72131387
102MP0005503_abnormal_tendon_morphology0.72066685
103MP0002078_abnormal_glucose_homeostasis0.71880359
104MP0002066_abnormal_motor_capabilities/c0.70844903
105MP0000778_abnormal_nervous_system0.70000357
106MP0010386_abnormal_urinary_bladder0.69597314
107MP0003690_abnormal_glial_cell0.69369867
108MP0005084_abnormal_gallbladder_morpholo0.69010078
109MP0006036_abnormal_mitochondrial_physio0.68543726
110MP0002069_abnormal_eating/drinking_beha0.68388099
111MP0001905_abnormal_dopamine_level0.68330616
112MP0003121_genomic_imprinting0.67900032
113MP0000639_abnormal_adrenal_gland0.67375997
114MP0009379_abnormal_foot_pigmentation0.66983695
115MP0005448_abnormal_energy_balance0.66773420
116MP0005645_abnormal_hypothalamus_physiol0.66467389
117MP0000955_abnormal_spinal_cord0.66162059
118MP0000631_abnormal_neuroendocrine_gland0.62979140
119MP0000534_abnormal_ureter_morphology0.62968915
120MP0000566_synostosis0.62230457
121MP0002653_abnormal_ependyma_morphology0.62033935
122MP0003075_altered_response_to0.61865025
123MP0009642_abnormal_blood_homeostasis0.60926213
124MP0000751_myopathy0.58938624
125MP0001299_abnormal_eye_distance/0.57997919
126MP0010769_abnormal_survival0.57956212
127MP0001943_abnormal_respiration0.57571968
128MP0005376_homeostasis/metabolism_phenot0.56874124
129MP0005187_abnormal_penis_morphology0.56040224
130MP0004145_abnormal_muscle_electrophysio0.55713987
131MP0002082_postnatal_lethality0.55591767
132MP0010770_preweaning_lethality0.55591767
133MP0002229_neurodegeneration0.55425098
134MP0004147_increased_porphyrin_level0.55080589
135MP0010768_mortality/aging0.54834835
136MP0004085_abnormal_heartbeat0.54571449
137MP0002882_abnormal_neuron_morphology0.54297678
138MP0000598_abnormal_liver_morphology0.54045606
139MP0005167_abnormal_blood-brain_barrier0.53268223
140MP0003011_delayed_dark_adaptation0.53013941
141MP0009764_decreased_sensitivity_to0.52528216
142MP0004883_abnormal_blood_vessel0.52026242
143MP0003953_abnormal_hormone_level0.51479272
144MP0005334_abnormal_fat_pad0.51140184
145MP0009643_abnormal_urine_homeostasis0.50065788
146MP0008569_lethality_at_weaning0.49988082
147MP0002090_abnormal_vision0.49352239
148MP0005166_decreased_susceptibility_to0.48384439

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.24719227
2Abnormality of aromatic amino acid family metabolism (HP:0004338)5.97375012
3Intrahepatic cholestasis (HP:0001406)5.59569073
4Prolonged partial thromboplastin time (HP:0003645)5.33882080
5Hypobetalipoproteinemia (HP:0003563)5.26032312
6Abnormality of monocarboxylic acid metabolism (HP:0010996)5.07012281
7Xanthomatosis (HP:0000991)4.98195946
8Diplopia (HP:0000651)4.80770561
9Abnormality of binocular vision (HP:0011514)4.80770561
10Hyperlipoproteinemia (HP:0010980)4.57806170
11Focal motor seizures (HP:0011153)4.48368536
12Complement deficiency (HP:0004431)4.27259159
13Supranuclear gaze palsy (HP:0000605)4.12267910
14Hyperventilation (HP:0002883)3.89094319
15Hypolipoproteinemia (HP:0010981)3.80077218
16Myokymia (HP:0002411)3.78330434
17Abnormal eating behavior (HP:0100738)3.65626473
18Limb dystonia (HP:0002451)3.60069832
19Joint hemorrhage (HP:0005261)3.53614086
20Epidermoid cyst (HP:0200040)3.53146769
21Ankle clonus (HP:0011448)3.51960530
22Hyperglycinemia (HP:0002154)3.50876720
23Hyperammonemia (HP:0001987)3.47548022
24Conjugated hyperbilirubinemia (HP:0002908)3.47166081
25Ketosis (HP:0001946)3.42457388
26Abnormality of the common coagulation pathway (HP:0010990)3.36674998
27Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.36097004
28Abnormality of methionine metabolism (HP:0010901)3.33657230
29Postural instability (HP:0002172)3.32150932
30Neurofibrillary tangles (HP:0002185)3.31851479
31Genetic anticipation (HP:0003743)3.25675996
32Urinary bladder sphincter dysfunction (HP:0002839)3.25467227
33Hypoalphalipoproteinemia (HP:0003233)3.25434577
34Obstructive sleep apnea (HP:0002870)3.24126725
35Abnormality of glutamine family amino acid metabolism (HP:0010902)3.16646485
36Abnormality of aspartate family amino acid metabolism (HP:0010899)3.16283629
37Abnormality of sulfur amino acid metabolism (HP:0004339)3.15340325
38Abnormal gallbladder physiology (HP:0012438)3.12328390
39Cholecystitis (HP:0001082)3.12328390
40Spastic gait (HP:0002064)3.12036964
41Focal seizures (HP:0007359)3.09854392
42Spontaneous abortion (HP:0005268)3.07934724
43Fat malabsorption (HP:0002630)3.06730140
44Atonic seizures (HP:0010819)3.03725157
45Truncal ataxia (HP:0002078)2.97934381
46Papilledema (HP:0001085)2.93307075
47Epileptic encephalopathy (HP:0200134)2.91873144
48Abnormality of complement system (HP:0005339)2.90567576
49Status epilepticus (HP:0002133)2.86239377
50Annular pancreas (HP:0001734)2.82097938
51Dysmetria (HP:0001310)2.76053641
52Abnormality of glycine metabolism (HP:0010895)2.75809097
53Abnormality of serine family amino acid metabolism (HP:0010894)2.75809097
54Hypercholesterolemia (HP:0003124)2.69948943
55Abnormality of the lower motor neuron (HP:0002366)2.69912680
56Hemiparesis (HP:0001269)2.67206861
57Hyperglycinuria (HP:0003108)2.65933314
58Mutism (HP:0002300)2.64541012
59Absence seizures (HP:0002121)2.64142265
60Hyperbilirubinemia (HP:0002904)2.63767364
61Sleep apnea (HP:0010535)2.60947408
62Abnormality of the intrinsic pathway (HP:0010989)2.58933642
63Cerebral hypomyelination (HP:0006808)2.56613492
64Impaired smooth pursuit (HP:0007772)2.55144279
65Abnormality of pyrimidine metabolism (HP:0004353)2.54666662
66Neonatal onset (HP:0003623)2.52614357
67Skin nodule (HP:0200036)2.51855290
68Anxiety (HP:0000739)2.51081905
69Ketoacidosis (HP:0001993)2.50817268
70Dialeptic seizures (HP:0011146)2.50363570
71Hemiplegia (HP:0002301)2.50203406
72Abnormal gallbladder morphology (HP:0012437)2.49018121
73Cholelithiasis (HP:0001081)2.48985046
74Cerebral edema (HP:0002181)2.48680053
75Depression (HP:0000716)2.45992012
76Intention tremor (HP:0002080)2.43803249
77Abnormality of the corticospinal tract (HP:0002492)2.43636617
78Febrile seizures (HP:0002373)2.41980860
79Generalized tonic-clonic seizures (HP:0002069)2.40993669
80Polyphagia (HP:0002591)2.39880172
81Abnormality of serum amino acid levels (HP:0003112)2.39401269
82Delusions (HP:0000746)2.35984269
83Sensorimotor neuropathy (HP:0007141)2.35910710
84Delayed CNS myelination (HP:0002188)2.35286512
85Lower limb muscle weakness (HP:0007340)2.34424475
86Hypochromic microcytic anemia (HP:0004840)2.34361304
87Visual hallucinations (HP:0002367)2.33946381
88Bradykinesia (HP:0002067)2.32255558
89Metabolic acidosis (HP:0001942)2.31224562
90Mitral stenosis (HP:0001718)2.30689696
91Broad-based gait (HP:0002136)2.30653318
92Urinary urgency (HP:0000012)2.30193954
93Dysdiadochokinesis (HP:0002075)2.29029101
94Drooling (HP:0002307)2.28945790
95Gaze-evoked nystagmus (HP:0000640)2.28417883
96Insomnia (HP:0100785)2.27355366
97Termporal pattern (HP:0011008)2.22982022
98Insidious onset (HP:0003587)2.22982022
99Hypoglycemic coma (HP:0001325)2.22442632
100Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.21681878
101Myotonia (HP:0002486)2.21016118
102Akinesia (HP:0002304)2.19703124
103Lethargy (HP:0001254)2.19378626
104Fair hair (HP:0002286)2.16319990
105Peripheral hypomyelination (HP:0007182)2.15300893
106Steatorrhea (HP:0002570)2.15256608
107Acanthocytosis (HP:0001927)2.14759510
108Neuronal loss in central nervous system (HP:0002529)2.14576594
109Gout (HP:0001997)2.13445475
110Incomplete penetrance (HP:0003829)2.12723074
111Abnormality of nucleobase metabolism (HP:0010932)2.12084376
112Stereotypic behavior (HP:0000733)2.07857203
113Impaired vibration sensation in the lower limbs (HP:0002166)2.07019816
114Hypsarrhythmia (HP:0002521)2.06336754
115Abnormality of fatty-acid metabolism (HP:0004359)2.06096880
116Excessive salivation (HP:0003781)2.05860062
117Prolonged QT interval (HP:0001657)2.03468952
118Dysmetric saccades (HP:0000641)2.03265021
119Abnormality of the gallbladder (HP:0005264)2.01108646
120Irritability (HP:0000737)2.00845957
121Torticollis (HP:0000473)1.99771958
122Clonus (HP:0002169)1.98738580
123Craniofacial dystonia (HP:0012179)1.97869622
124Action tremor (HP:0002345)1.97858115
125Abnormality of ocular smooth pursuit (HP:0000617)1.97810925
126Epileptiform EEG discharges (HP:0011182)1.97409513
127Progressive cerebellar ataxia (HP:0002073)1.97276629
128Megalencephaly (HP:0001355)1.96872311
129Focal dystonia (HP:0004373)1.96580418
130Morphological abnormality of the pyramidal tract (HP:0002062)1.93358040
131Pheochromocytoma (HP:0002666)1.92650392
132Amblyopia (HP:0000646)1.90945133
133Abnormality of purine metabolism (HP:0004352)1.90793233
134Rigidity (HP:0002063)1.90599603
135Abnormality of saccadic eye movements (HP:0000570)1.90225575
136Amyloidosis (HP:0011034)1.90090417
137Hepatocellular carcinoma (HP:0001402)1.88993004
138Abnormal social behavior (HP:0012433)1.88471149
139Impaired social interactions (HP:0000735)1.88471149
140Degeneration of the lateral corticospinal tracts (HP:0002314)1.88297660
141Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.88297660
142Hypoventilation (HP:0002791)1.87281483
143Cerebral inclusion bodies (HP:0100314)1.87171191
144Retinal dysplasia (HP:0007973)1.86008115
145Aplasia involving bones of the upper limbs (HP:0009823)1.85865349
146Aplasia of the phalanges of the hand (HP:0009802)1.85865349
147Aplasia involving bones of the extremities (HP:0009825)1.85865349
148Apathy (HP:0000741)1.85164089
149Poor eye contact (HP:0000817)1.84723528
150Spastic tetraparesis (HP:0001285)1.84542291
151Turricephaly (HP:0000262)1.84255736
152Myocardial infarction (HP:0001658)1.83702129
153Vascular calcification (HP:0004934)1.83658181
154Abnormality of the Achilles tendon (HP:0005109)1.82085175
155Vomiting (HP:0002013)1.81818518
156Malnutrition (HP:0004395)1.80659901
157Impaired pain sensation (HP:0007328)1.79437846
158Abnormality of pain sensation (HP:0010832)1.79437846
159Cerebral hemorrhage (HP:0001342)1.79261577
160Rapidly progressive (HP:0003678)1.78582940
161Glomerulonephritis (HP:0000099)1.78057460
162Impaired vibratory sensation (HP:0002495)1.77984877
163Tetraplegia (HP:0002445)1.77736120
164EEG with generalized epileptiform discharges (HP:0011198)1.77332440
165Absent speech (HP:0001344)1.72282090
166Abnormal EKG (HP:0003115)1.71007788
167Mild short stature (HP:0003502)1.69681944
168Narrow nasal bridge (HP:0000446)1.67707526
169Fetal akinesia sequence (HP:0001989)1.62649094
170Lower limb amyotrophy (HP:0007210)1.62145759
171Diminished motivation (HP:0000745)1.61708048
172CNS hypomyelination (HP:0003429)1.61182795
173Hypoplasia of the iris (HP:0007676)1.59229598

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.54620925
2EPHA44.18584396
3DAPK23.86657210
4NTRK33.77425908
5MAP2K43.08721915
6MAP3K42.77561223
7MAP3K92.71824313
8UHMK12.66442996
9MAP3K122.56852571
10MAP2K72.53851160
11GRK52.36701956
12DAPK12.15310392
13MINK12.14893972
14KSR22.12312772
15PLK21.94680079
16BCKDK1.81411596
17PRKD31.81280149
18CDK191.74874084
19ARAF1.66701527
20RIPK41.66370149
21CCNB11.56107452
22PAK61.54077755
23RIPK11.46816122
24PTK2B1.45225643
25NTRK11.42736219
26TYRO31.39179744
27MAP3K21.33752128
28KSR11.33451366
29PRKCG1.32494138
30FGFR41.28853633
31PHKG11.25308359
32PHKG21.25308359
33SIK31.22106345
34DYRK1A1.19337578
35SIK11.18664017
36AKT31.16570195
37CAMKK11.16565221
38MARK21.10107603
39RET1.09415924
40MAP3K131.09116815
41PRPF4B1.07482811
42SGK2231.05436933
43SGK4941.05436933
44SGK21.04903901
45CAMK2A1.02921992
46LATS21.01639570
47CAMKK20.99874385
48CDK50.96588468
49MARK10.94637740
50DDR20.93963220
51PKN10.93097277
52FRK0.92261347
53INSRR0.90529946
54OXSR10.89595967
55MAPK120.88840888
56GRK60.83780155
57NTRK20.83481751
58MAP2K10.83420080
59CAMK1G0.83323874
60CAMK2B0.81410226
61MAP3K70.80263542
62FGFR20.79849976
63MAPK130.78686078
64SIK20.77458072
65FER0.77096250
66SGK30.73856735
67ICK0.73497473
68CAMK2G0.73382222
69TNIK0.71808287
70DAPK30.69906537
71PDPK10.69028866
72PRKCZ0.67642273
73MAP3K10.67423787
74DYRK20.67161479
75ERBB40.66868857
76BRAF0.65854425
77PINK10.65457267
78WNK10.63203551
79PDK10.62754459
80RAF10.62270993
81BMPR20.61782830
82MOS0.60641093
83ADRBK10.58907895
84CDK180.58622609
85MAPK100.57948366
86MAPK70.56932541
87BRSK10.56561267
88CDK140.56246107
89CAMK1D0.55643572
90RPS6KA30.55363850
91MAPK40.55278083
92CSNK1G20.53843777
93ALK0.52838730
94PAK30.52782912
95ROCK20.52060374
96EPHB20.52017490
97CDK150.51984682
98MST1R0.51212877
99NEK60.50855179
100FES0.50653183
101CAMK10.50233967
102NME10.49690452
103STK380.49437870
104FGR0.48497083
105CAMK40.47667648
106ABL20.46932208
107LIMK10.45492128
108DYRK1B0.44937998
109MAPKAPK50.44818488
110MAPK110.43687680
111PRKACG0.43408598
112SGK10.41779144
113ERN10.41651715
114PRKCE0.40989131
115LMTK20.40373658
116CDK11A0.40099096
117STK110.37198217
118JAK20.37069533
119PDK40.36700233
120PDK30.36700233
121PRKCA0.36130666
122PRKACA0.35771316
123PNCK0.35718041
124TESK10.35381573
125PRKCH0.35280217
126CAMK2D0.35035984
127PRKAA10.33663114
128MAP3K110.33494762
129PRKG10.32268426
130TRIB30.31812189
131MYLK0.31407246
132FYN0.30980171
133PRKCB0.29837062

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.23213689
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.83144649
3Nitrogen metabolism_Homo sapiens_hsa009103.39178636
4Arginine biosynthesis_Homo sapiens_hsa002203.03657047
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.77430701
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.55987145
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.37159560
8Complement and coagulation cascades_Homo sapiens_hsa046102.37068552
9Tryptophan metabolism_Homo sapiens_hsa003802.14481218
10Fatty acid degradation_Homo sapiens_hsa000711.88893899
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.87413051
12Butanoate metabolism_Homo sapiens_hsa006501.84198779
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.79986452
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.73442016
15Steroid hormone biosynthesis_Homo sapiens_hsa001401.72625031
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.72054310
17Peroxisome_Homo sapiens_hsa041461.67069005
18Bile secretion_Homo sapiens_hsa049761.66506177
19Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.63170396
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.57962583
21Chemical carcinogenesis_Homo sapiens_hsa052041.57391967
22Propanoate metabolism_Homo sapiens_hsa006401.54441139
23Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.54310541
24Nicotine addiction_Homo sapiens_hsa050331.53871945
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.52553588
26Pyruvate metabolism_Homo sapiens_hsa006201.51357472
27Synaptic vesicle cycle_Homo sapiens_hsa047211.51309736
28PPAR signaling pathway_Homo sapiens_hsa033201.48572785
29cAMP signaling pathway_Homo sapiens_hsa040241.44382672
30Fatty acid metabolism_Homo sapiens_hsa012121.44161556
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.43724852
32Phenylalanine metabolism_Homo sapiens_hsa003601.38393186
33Histidine metabolism_Homo sapiens_hsa003401.36263166
34Gap junction_Homo sapiens_hsa045401.34977259
35Cardiac muscle contraction_Homo sapiens_hsa042601.34049333
36Retinol metabolism_Homo sapiens_hsa008301.26493741
37Drug metabolism - other enzymes_Homo sapiens_hsa009831.25394061
38Melanogenesis_Homo sapiens_hsa049161.24252127
39Tyrosine metabolism_Homo sapiens_hsa003501.20904383
40Estrogen signaling pathway_Homo sapiens_hsa049151.20404748
41Caffeine metabolism_Homo sapiens_hsa002321.19313649
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.18788756
43Axon guidance_Homo sapiens_hsa043601.17343005
44Glioma_Homo sapiens_hsa052141.14951316
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.14709545
46Staphylococcus aureus infection_Homo sapiens_hsa051501.14304423
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.11815921
48beta-Alanine metabolism_Homo sapiens_hsa004101.08014212
49Sulfur metabolism_Homo sapiens_hsa009201.07774063
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.07183656
51Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.04931934
52cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04222792
53Phospholipase D signaling pathway_Homo sapiens_hsa040721.01514872
54Fatty acid elongation_Homo sapiens_hsa000621.00055567
55Starch and sucrose metabolism_Homo sapiens_hsa005000.98633423
56Biosynthesis of amino acids_Homo sapiens_hsa012300.95941075
57Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.93130922
58Phototransduction_Homo sapiens_hsa047440.92524073
59Carbon metabolism_Homo sapiens_hsa012000.91734786
60Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90718891
61Steroid biosynthesis_Homo sapiens_hsa001000.90295597
62ErbB signaling pathway_Homo sapiens_hsa040120.88049870
63Long-term potentiation_Homo sapiens_hsa047200.87984446
64Type II diabetes mellitus_Homo sapiens_hsa049300.85009436
65Cyanoamino acid metabolism_Homo sapiens_hsa004600.84761008
66Amphetamine addiction_Homo sapiens_hsa050310.84455802
67GABAergic synapse_Homo sapiens_hsa047270.84391613
68ABC transporters_Homo sapiens_hsa020100.83873030
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83734621
70Collecting duct acid secretion_Homo sapiens_hsa049660.83601373
71Glutamatergic synapse_Homo sapiens_hsa047240.82959450
72Oocyte meiosis_Homo sapiens_hsa041140.82872355
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.82777943
74Circadian entrainment_Homo sapiens_hsa047130.77911717
75Fat digestion and absorption_Homo sapiens_hsa049750.77763693
76Pancreatic secretion_Homo sapiens_hsa049720.74860375
77Ras signaling pathway_Homo sapiens_hsa040140.74452690
78Vibrio cholerae infection_Homo sapiens_hsa051100.74422736
79Thyroid hormone synthesis_Homo sapiens_hsa049180.72804320
80Selenocompound metabolism_Homo sapiens_hsa004500.70620233
81Dilated cardiomyopathy_Homo sapiens_hsa054140.70368875
82Olfactory transduction_Homo sapiens_hsa047400.70233001
83Rap1 signaling pathway_Homo sapiens_hsa040150.67404651
84Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.67381782
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.67208972
86MAPK signaling pathway_Homo sapiens_hsa040100.65774507
87Dorso-ventral axis formation_Homo sapiens_hsa043200.65247131
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64954478
89Insulin secretion_Homo sapiens_hsa049110.64814137
90Taste transduction_Homo sapiens_hsa047420.62684082
91Salivary secretion_Homo sapiens_hsa049700.62405125
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62171510
93Morphine addiction_Homo sapiens_hsa050320.61236451
94Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.61152212
95VEGF signaling pathway_Homo sapiens_hsa043700.61056077
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60949628
97Alcoholism_Homo sapiens_hsa050340.60652716
98Glycerolipid metabolism_Homo sapiens_hsa005610.60465627
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57468886
100Vitamin B6 metabolism_Homo sapiens_hsa007500.57027422
101Dopaminergic synapse_Homo sapiens_hsa047280.56972856
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56463027
103Arginine and proline metabolism_Homo sapiens_hsa003300.56175539
104Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54882601
105Prion diseases_Homo sapiens_hsa050200.52394120
106Inositol phosphate metabolism_Homo sapiens_hsa005620.51668440
107Circadian rhythm_Homo sapiens_hsa047100.49101565
108Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48260875
109Fatty acid biosynthesis_Homo sapiens_hsa000610.48147490
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46831909
111Wnt signaling pathway_Homo sapiens_hsa043100.46256208
112Renin secretion_Homo sapiens_hsa049240.44652254
113Vitamin digestion and absorption_Homo sapiens_hsa049770.44632829
114Choline metabolism in cancer_Homo sapiens_hsa052310.44450958
115Oxidative phosphorylation_Homo sapiens_hsa001900.44292736
116Glucagon signaling pathway_Homo sapiens_hsa049220.43491308
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42739820
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42420201
119AMPK signaling pathway_Homo sapiens_hsa041520.42018922
120Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41417598
121Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39351251
122Sulfur relay system_Homo sapiens_hsa041220.38629897
123Maturity onset diabetes of the young_Homo sapiens_hsa049500.37453384
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34726384
125Ovarian steroidogenesis_Homo sapiens_hsa049130.34724828
126Calcium signaling pathway_Homo sapiens_hsa040200.34700473
127Folate biosynthesis_Homo sapiens_hsa007900.34517878
128Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.34065450
129Gastric acid secretion_Homo sapiens_hsa049710.33340809
130Endocytosis_Homo sapiens_hsa041440.33299876
131Hippo signaling pathway_Homo sapiens_hsa043900.32722335
132Metabolic pathways_Homo sapiens_hsa011000.31172437
133Hedgehog signaling pathway_Homo sapiens_hsa043400.31013680
134Cholinergic synapse_Homo sapiens_hsa047250.30868374
135Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.30519019
136Alzheimers disease_Homo sapiens_hsa050100.30446252
137Parkinsons disease_Homo sapiens_hsa050120.29880474
138Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.29823496
139Insulin signaling pathway_Homo sapiens_hsa049100.29804281
140Oxytocin signaling pathway_Homo sapiens_hsa049210.29134272
141Long-term depression_Homo sapiens_hsa047300.28127345
142Serotonergic synapse_Homo sapiens_hsa047260.27720769
143Sphingolipid signaling pathway_Homo sapiens_hsa040710.27166960
144Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.27148872
145mTOR signaling pathway_Homo sapiens_hsa041500.26599520
146Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.24522723
147Cocaine addiction_Homo sapiens_hsa050300.22548859
148Renal cell carcinoma_Homo sapiens_hsa052110.22330788
149HIF-1 signaling pathway_Homo sapiens_hsa040660.22313905
150Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.21853520
151GnRH signaling pathway_Homo sapiens_hsa049120.21630678
152SNARE interactions in vesicular transport_Homo sapiens_hsa041300.21511674
153Endometrial cancer_Homo sapiens_hsa052130.20957603
154Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.17782600

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