NRL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a basic motif-leucine zipper transcription factor of the Maf subfamily. The encoded protein is conserved among vertebrates and is a critical intrinsic regulator of photoceptor development and function. Mutations in this gene have been associated with retinitis pigmentosa and retinal degenerative diseases. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1GMP metabolic process (GO:0046037)9.96858743
2detection of visible light (GO:0009584)9.76717796
3protein-chromophore linkage (GO:0018298)8.95231171
4* visual perception (GO:0007601)8.83193121
5* sensory perception of light stimulus (GO:0050953)8.72820326
6eye photoreceptor cell differentiation (GO:0001754)7.72242470
7photoreceptor cell differentiation (GO:0046530)7.72242470
8* retinal rod cell development (GO:0046548)7.52194067
9positive regulation of guanylate cyclase activity (GO:0031284)7.21345889
10cellular response to light stimulus (GO:0071482)7.08022170
11detection of external stimulus (GO:0009581)7.03465930
12retina development in camera-type eye (GO:0060041)7.02341923
13detection of abiotic stimulus (GO:0009582)6.88992034
14cellular response to electrical stimulus (GO:0071257)6.87115223
15regulation of guanylate cyclase activity (GO:0031282)6.50131391
16ribosomal small subunit assembly (GO:0000028)6.04488488
17maturation of SSU-rRNA (GO:0030490)5.77349884
18ribosomal small subunit biogenesis (GO:0042274)5.44543165
19regulation of clathrin-mediated endocytosis (GO:2000369)5.44250534
20regulation of inhibitory postsynaptic membrane potential (GO:0060080)5.21864834
21regulation of cGMP metabolic process (GO:0030823)5.08047303
22negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)5.07890895
23peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)4.90015649
24adaptation of signaling pathway (GO:0023058)4.80769700
25cell differentiation involved in metanephros development (GO:0072202)4.77048824
26positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.66087307
27cellular response to radiation (GO:0071478)4.51417757
28negative regulation of astrocyte differentiation (GO:0048712)4.49182752
29nonmotile primary cilium assembly (GO:0035058)4.44536277
30regulation of short-term neuronal synaptic plasticity (GO:0048172)4.38722205
31retina layer formation (GO:0010842)4.33683574
32estrogen biosynthetic process (GO:0006703)4.33494832
33positive regulation of cGMP biosynthetic process (GO:0030828)4.26781078
34* sensory perception (GO:0007600)4.15765627
35proline biosynthetic process (GO:0006561)4.12225890
36neuroblast proliferation (GO:0007405)4.11418764
37regulation of cGMP biosynthetic process (GO:0030826)3.99625819
38regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)3.95120029
39response to light stimulus (GO:0009416)3.89068858
40cell morphogenesis involved in neuron differentiation (GO:0048667)3.83034390
41positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.81270973
42positive regulation of gastrulation (GO:2000543)3.80150197
43synaptic vesicle maturation (GO:0016188)3.77532207
44Arp2/3 complex-mediated actin nucleation (GO:0034314)3.75620401
45positive regulation of cGMP metabolic process (GO:0030825)3.73844775
46detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.72773458
47negative regulation of receptor-mediated endocytosis (GO:0048261)3.72576749
48positive regulation of respiratory burst (GO:0060267)3.71865101
49viral transcription (GO:0019083)3.68449168
50protein polyglutamylation (GO:0018095)3.66627125
51prenylation (GO:0097354)3.61558835
52protein prenylation (GO:0018342)3.61558835
53positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)3.60235099
54spinal cord association neuron differentiation (GO:0021527)3.59274001
55* neuron development (GO:0048666)3.55142552
56translational termination (GO:0006415)3.50172329
57regulation of voltage-gated calcium channel activity (GO:1901385)3.46953260
58neuron fate determination (GO:0048664)3.46929583
59L-glutamate transport (GO:0015813)3.45063325
60protein localization to synapse (GO:0035418)3.44592472
61receptor guanylyl cyclase signaling pathway (GO:0007168)3.40184824
62positive regulation of ERBB signaling pathway (GO:1901186)3.39332510
63retinoic acid receptor signaling pathway (GO:0048384)3.37558181
64CDP-diacylglycerol biosynthetic process (GO:0016024)3.35906731
65retina homeostasis (GO:0001895)3.35193648
66actin nucleation (GO:0045010)3.34653707
67acidic amino acid transport (GO:0015800)3.32126768
68deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.27836170
69regulation of Golgi to plasma membrane protein transport (GO:0042996)3.26981982
70synaptic vesicle docking involved in exocytosis (GO:0016081)3.25995438
71retinoid metabolic process (GO:0001523)3.22776280
72lipoprotein transport (GO:0042953)3.22634507
73positive regulation of cell cycle checkpoint (GO:1901978)3.19994896
74axoneme assembly (GO:0035082)3.17788868
75CDP-diacylglycerol metabolic process (GO:0046341)3.07845612
76membrane hyperpolarization (GO:0060081)3.05989291
77translational elongation (GO:0006414)3.04305882
78positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.02796034
79diterpenoid metabolic process (GO:0016101)3.00029793
80phospholipid translocation (GO:0045332)2.98889854
81lipid translocation (GO:0034204)2.98889854
82vitamin A metabolic process (GO:0006776)2.98491845
83response to electrical stimulus (GO:0051602)2.98111695
84mature B cell differentiation involved in immune response (GO:0002313)2.93256203
85synapsis (GO:0007129)2.92877765
86response to UV-C (GO:0010225)2.89002285
87proline metabolic process (GO:0006560)2.88524584
88cellular potassium ion homeostasis (GO:0030007)2.86617446
89regulation of mitotic spindle checkpoint (GO:1903504)2.86402821
90regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.86402821
91negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.86284086
92sodium ion export (GO:0071436)2.82831151
93positive regulation of neurotransmitter transport (GO:0051590)2.82731213
94virion assembly (GO:0019068)2.79553578
95negative regulation of glial cell differentiation (GO:0045686)2.79267825
96response to pheromone (GO:0019236)2.76976967
97positive regulation of vesicle fusion (GO:0031340)2.76241145
98sensory perception of taste (GO:0050909)2.75995894
99potassium ion homeostasis (GO:0055075)2.75206871
100detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.74682409
101maternal behavior (GO:0042711)2.74373420
102terpenoid metabolic process (GO:0006721)2.74063166
103pyrimidine nucleobase catabolic process (GO:0006208)2.73673771
104regulation of astrocyte differentiation (GO:0048710)2.72542746
105negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.71685852
106mature B cell differentiation (GO:0002335)2.71316562
107post-embryonic morphogenesis (GO:0009886)2.71053587
108viral life cycle (GO:0019058)2.66177189
109nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.65617016
110positive regulation of protein homooligomerization (GO:0032464)2.65184344
111regulation of NFAT protein import into nucleus (GO:0051532)2.64828678
112negative regulation by host of viral transcription (GO:0043922)2.63625175
113UV protection (GO:0009650)2.62070918
114negative regulation of gliogenesis (GO:0014014)2.61939124
115response to radiation (GO:0009314)2.61456896
116protein insertion into membrane (GO:0051205)2.60472302
117piRNA metabolic process (GO:0034587)2.59884027
118cellular protein complex disassembly (GO:0043624)2.59417538
119regulation of synaptic vesicle exocytosis (GO:2000300)2.59291633
120negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.58677500
121glutamate secretion (GO:0014047)2.58619751
122positive regulation of sodium ion transmembrane transport (GO:1902307)2.58469346
123positive regulation of lymphocyte apoptotic process (GO:0070230)2.58192450
124single strand break repair (GO:0000012)2.56582320
125positive regulation of protein homodimerization activity (GO:0090073)2.55097767
126synaptic vesicle exocytosis (GO:0016079)2.54411680
127lactate metabolic process (GO:0006089)2.53658465
128protein targeting to ER (GO:0045047)2.51005020
129SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.50679879
130T cell apoptotic process (GO:0070231)2.50178291
131chemosensory behavior (GO:0007635)2.48778631
132tachykinin receptor signaling pathway (GO:0007217)2.47820676
133nephron tubule morphogenesis (GO:0072078)2.47021599
134nephron epithelium morphogenesis (GO:0072088)2.47021599
135establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.45844754
136mitochondrion transport along microtubule (GO:0047497)2.45844754
137positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.44517025
138positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.42657768
139retinol metabolic process (GO:0042572)2.42321878
140righting reflex (GO:0060013)2.41499279
141short-term memory (GO:0007614)2.38063784
142appendage development (GO:0048736)2.32232034
143limb development (GO:0060173)2.32232034
144regulation of synaptic vesicle transport (GO:1902803)2.31024565
145negative regulation of transcription regulatory region DNA binding (GO:2000678)2.30685767
146dopamine receptor signaling pathway (GO:0007212)2.29704547
147protein heterotetramerization (GO:0051290)2.28791892
148potassium ion import (GO:0010107)2.28308388
149behavioral response to ethanol (GO:0048149)2.27445105
150cellular response to abiotic stimulus (GO:0071214)2.26955848
151startle response (GO:0001964)2.26563503
152response to histamine (GO:0034776)2.23657634
153regulation of rhodopsin mediated signaling pathway (GO:0022400)16.5736424
154rhodopsin mediated signaling pathway (GO:0016056)16.2789020
155retinal cone cell development (GO:0046549)14.1429756
156photoreceptor cell maintenance (GO:0045494)12.5126749
157* photoreceptor cell development (GO:0042461)11.8742787
158* eye photoreceptor cell development (GO:0042462)10.9264423
159phototransduction (GO:0007602)10.6310394
160phototransduction, visible light (GO:0007603)10.2739085
161detection of light stimulus involved in visual perception (GO:0050908)10.2286270
162detection of light stimulus involved in sensory perception (GO:0050962)10.2286270
163detection of light stimulus (GO:0009583)10.0280686

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.48160180
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.23807170
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.92447429
4CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse3.92209395
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.48034338
6RBPJ_22232070_ChIP-Seq_NCS_Mouse3.45147946
7CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.70681436
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.65793671
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.61694866
10GBX2_23144817_ChIP-Seq_PC3_Human2.38493350
11STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.16543606
12DROSHA_22980978_ChIP-Seq_HELA_Human2.15229275
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.08197047
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.99654095
15NFE2_27457419_Chip-Seq_LIVER_Mouse1.92265524
16FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.91916729
17CBX2_22325352_ChIP-Seq_293T-Rex_Human1.91251193
18* SA1_27219007_Chip-Seq_Bcells_Human1.90962745
19BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.89343613
20SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.88178487
21* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.87012295
22RARB_27405468_Chip-Seq_BRAIN_Mouse1.84012223
23VDR_21846776_ChIP-Seq_THP-1_Human1.83777218
24MYC_22102868_ChIP-Seq_BL_Human1.82755730
25STAT6_21828071_ChIP-Seq_BEAS2B_Human1.81750861
26CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.81142085
27VDR_22108803_ChIP-Seq_LS180_Human1.80121867
28SUZ12_27294783_Chip-Seq_NPCs_Mouse1.80111031
29* KDM2B_26808549_Chip-Seq_K562_Human1.79326742
30REST_18959480_ChIP-ChIP_MESCs_Mouse1.79199964
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.76652967
32REST_21632747_ChIP-Seq_MESCs_Mouse1.76438224
33DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.76045112
34MTF2_20144788_ChIP-Seq_MESCs_Mouse1.75804661
35ETV1_20927104_ChIP-Seq_GIST48_Human1.75041006
36* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.74682283
37EZH2_18974828_ChIP-Seq_MESCs_Mouse1.74646703
38RNF2_18974828_ChIP-Seq_MESCs_Mouse1.74646703
39FLI1_27457419_Chip-Seq_LIVER_Mouse1.70862032
40* EZH2_27294783_Chip-Seq_ESCs_Mouse1.69714737
41SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.66847571
42SMAD3_21741376_ChIP-Seq_HESCs_Human1.66189632
43TCF4_18268006_ChIP-ChIP_LS174T_Human1.62350680
44SCL_19346495_ChIP-Seq_HPC-7_Human1.61812035
45EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59442927
46TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.56958882
47P53_22127205_ChIP-Seq_FIBROBLAST_Human1.56853046
48TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56786714
49RING1B_27294783_Chip-Seq_NPCs_Mouse1.56164140
50AR_19668381_ChIP-Seq_PC3_Human1.55259842
51AR_21572438_ChIP-Seq_LNCaP_Human1.55243410
52HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.55162466
53HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.55017813
54GATA1_22025678_ChIP-Seq_K562_Human1.54257423
55JARID2_20075857_ChIP-Seq_MESCs_Mouse1.53375684
56JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.51613698
57GATA6_21074721_ChIP-Seq_CACO-2_Human1.51344042
58IKZF1_21737484_ChIP-ChIP_HCT116_Human1.50222024
59MAF_26560356_Chip-Seq_TH2_Human1.50087789
60PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.49799245
61SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.49388641
62ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.49279408
63CTCF_27219007_Chip-Seq_Bcells_Human1.48190480
64SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.48096397
65ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.47708714
66ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.47434776
67TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.47137903
68GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.45074082
69RNF2_27304074_Chip-Seq_ESCs_Mouse1.44479519
70MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.43313845
71RBPJ_21746931_ChIP-Seq_IB4_Human1.42268593
72EP300_21415370_ChIP-Seq_HL-1_Mouse1.39497545
73ERG_21242973_ChIP-ChIP_JURKAT_Human1.36513127
74BCL6_27268052_Chip-Seq_Bcells_Human1.36452023
75SMAD4_21799915_ChIP-Seq_A2780_Human1.35996789
76PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35753553
77SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.35454851
78DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.35130574
79GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.34919416
80POU3F2_20337985_ChIP-ChIP_501MEL_Human1.34748100
81SA1_27219007_Chip-Seq_ERYTHROID_Human1.33527753
82SMC4_20622854_ChIP-Seq_HELA_Human1.33382117
83TBL1_22424771_ChIP-Seq_293T_Human1.33188650
84ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.33100040
85* KDM2B_26808549_Chip-Seq_JURKAT_Human1.32246811
86EZH2_27304074_Chip-Seq_ESCs_Mouse1.30468486
87* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.30013288
88SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.27077572
89UTX_26944678_Chip-Seq_JUKART_Human1.26529464
90ETS1_20019798_ChIP-Seq_JURKAT_Human1.25247644
91SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.23679937
92EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.22743502
93* MAF_26560356_Chip-Seq_TH1_Human1.21622841
94PHF8_20622853_ChIP-Seq_HELA_Human1.21466714
95IRF8_21731497_ChIP-ChIP_J774_Mouse1.20463423
96ISL1_27105846_Chip-Seq_CPCs_Mouse1.20078482
97PCGF2_27294783_Chip-Seq_ESCs_Mouse1.19658004
98PHF8_20622854_ChIP-Seq_HELA_Human1.19453216
99THAP11_20581084_ChIP-Seq_MESCs_Mouse1.18513312
100STAT3_23295773_ChIP-Seq_U87_Human1.17614268
101TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17341099
102SRF_21415370_ChIP-Seq_HL-1_Mouse1.17203315
103CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.17070786
104BCAT_22108803_ChIP-Seq_LS180_Human1.16063441
105E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.14656306
106WDR5_24793694_ChIP-Seq_LNCAP_Human1.14578003
107XRN2_22483619_ChIP-Seq_HELA_Human1.14456209
108NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.13730986
109SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13360247
110* CREB1_26743006_Chip-Seq_LNCaP_Human1.11491123
111BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.10888972
112EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.09847238
113HNFA_21074721_ChIP-Seq_CACO-2_Human1.09462581
114EZH2_22144423_ChIP-Seq_EOC_Human1.08264522
115YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08168454
116RUNX1_27457419_Chip-Seq_LIVER_Mouse1.07002387
117ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06001157
118FOXP3_21729870_ChIP-Seq_TREG_Human1.05537313
119LXR_22292898_ChIP-Seq_THP-1_Human1.05431832
120TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04934272
121RING1B_27294783_Chip-Seq_ESCs_Mouse1.04867133
122SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.04689655
123NFYB_21822215_ChIP-Seq_K562_Human1.03608901
124* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.03498575
125P53_22387025_ChIP-Seq_ESCs_Mouse1.03315035
126WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02472636
127RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.02418192
128NFYA_21822215_ChIP-Seq_K562_Human1.01932536
129GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01802648
130BCOR_27268052_Chip-Seq_Bcells_Human1.01253635
131MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.01174563
132CTCF_27219007_Chip-Seq_ERYTHROID_Human1.00795007
133NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.00577785
134* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.00403725
135SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.00383505
136EGR1_19032775_ChIP-ChIP_M12_Human1.00094645
137SMAD4_21741376_ChIP-Seq_ESCs_Human0.99334435
138* JARID2_20064375_ChIP-Seq_MESCs_Mouse0.96775227
139* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96309692
140IGF1R_20145208_ChIP-Seq_DFB_Human0.96302216
141AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96283816
142GATA1_19941827_ChIP-Seq_MEL_Mouse0.96257931
143* KDM2B_26808549_Chip-Seq_DND41_Human0.95752561
144* SMAD4_21741376_ChIP-Seq_HESCs_Human0.95747104
145EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.95662785
146KDM2B_26808549_Chip-Seq_SUP-B15_Human0.95395660
147SMAD3_21741376_ChIP-Seq_ESCs_Human0.94995055
148RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.94914755
149CTCF_21964334_ChIP-Seq_BJAB-B_Human0.94896170
150PRDM14_20953172_ChIP-Seq_ESCs_Human0.93414893
151P68_20966046_ChIP-Seq_HELA_Human0.93383084
152CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93020235
153MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.93006270
154ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.92500083
155NFIB_24661679_ChIP-Seq_LUNG_Mouse0.91887356
156CBP_21632823_ChIP-Seq_H3396_Human0.91682367
157OCT1_27270436_Chip-Seq_PROSTATE_Human0.91590017
158OCT4_19829295_ChIP-Seq_ESCs_Human0.91527709
159FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.90339245
160P300_19829295_ChIP-Seq_ESCs_Human0.90202833
161CBX2_27304074_Chip-Seq_ESCs_Mouse0.89794885
162TET1_21451524_ChIP-Seq_MESCs_Mouse0.89395112
163AHR_22903824_ChIP-Seq_MCF-7_Human0.89369868
164ELK4_26923725_Chip-Seq_MESODERM_Mouse0.88833742
165HOXB7_26014856_ChIP-Seq_BT474_Human0.88778732
166* DPY_21335234_ChIP-Seq_ESCs_Mouse0.88775856
167ZFP281_18757296_ChIP-ChIP_E14_Mouse0.88582078
168KDM5A_27292631_Chip-Seq_BREAST_Human0.88378262
169GATA1_26923725_Chip-Seq_HPCs_Mouse0.88247447
170NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.88140944
171SOX2_21211035_ChIP-Seq_LN229_Gbm0.87999142
172TCF4_23295773_ChIP-Seq_U87_Human0.87964954
173MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.87465115
174GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.87020117
175TCF7_22412390_ChIP-Seq_EML_Mouse0.87014328
176SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.85696533
177CTCF_21964334_Chip-Seq_Bcells_Human0.85398690
178TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.85269779
179EZH2_27294783_Chip-Seq_NPCs_Mouse0.85149044
180GABP_17652178_ChIP-ChIP_JURKAT_Human0.85086386
181EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.84411430

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0005551_abnormal_eye_electrophysiolog9.07853223
2MP0002822_catalepsy7.22578964
3MP0005253_abnormal_eye_physiology6.78639619
4MP0006072_abnormal_retinal_apoptosis6.74814584
5* MP0005195_abnormal_posterior_eye3.86804556
6MP0001324_abnormal_eye_pigmentation3.70476936
7MP0005391_vision/eye_phenotype3.39612288
8MP0003950_abnormal_plasma_membrane3.01492690
9MP0002090_abnormal_vision2.83174890
10MP0009379_abnormal_foot_pigmentation2.82962451
11MP0002229_neurodegeneration2.71968136
12MP0002638_abnormal_pupillary_reflex2.62132338
13MP0005423_abnormal_somatic_nervous2.28457363
14MP0002653_abnormal_ependyma_morphology2.26831620
15MP0003011_delayed_dark_adaptation11.1512836
16* MP0002752_abnormal_somatic_nervous1.92758406
17MP0001764_abnormal_homeostasis1.71618549
18MP0001502_abnormal_circadian_rhythm1.62294922
19MP0006292_abnormal_olfactory_placode1.55064349
20MP0008877_abnormal_DNA_methylation1.53376994
21MP0001529_abnormal_vocalization1.49654829
22* MP0002882_abnormal_neuron_morphology1.43429943
23MP0004885_abnormal_endolymph1.36518505
24MP0001986_abnormal_taste_sensitivity1.28570241
25MP0004019_abnormal_vitamin_homeostasis1.24840804
26MP0005499_abnormal_olfactory_system1.18637793
27MP0005394_taste/olfaction_phenotype1.18637793
28MP0004270_analgesia1.16513594
29MP0005647_abnormal_sex_gland1.04992982
30MP0001919_abnormal_reproductive_system1.04413713
31MP0008789_abnormal_olfactory_epithelium1.03342516
32MP0003878_abnormal_ear_physiology1.02609885
33MP0005377_hearing/vestibular/ear_phenot1.02609885
34MP0005671_abnormal_response_to1.01700165
35MP0005197_abnormal_uvea_morphology1.01325749
36MP0003879_abnormal_hair_cell0.95055118
37MP0001486_abnormal_startle_reflex0.92596671
38MP0003880_abnormal_central_pattern0.91815098
39MP0001984_abnormal_olfaction0.90373082
40MP0004233_abnormal_muscle_weight0.89772481
41MP0003646_muscle_fatigue0.88734645
42MP0003634_abnormal_glial_cell0.87870430
43MP0004859_abnormal_synaptic_plasticity0.87250879
44MP0000569_abnormal_digit_pigmentation0.85817515
45MP0004147_increased_porphyrin_level0.82842830
46MP0005174_abnormal_tail_pigmentation0.78484158
47MP0002272_abnormal_nervous_system0.78026046
48MP0005187_abnormal_penis_morphology0.77801148
49MP0002127_abnormal_cardiovascular_syste0.76553761
50MP0005248_abnormal_Harderian_gland0.73563927
51MP0003183_abnormal_peptide_metabolism0.72437085
52MP0003635_abnormal_synaptic_transmissio0.72275609
53MP0002139_abnormal_hepatobiliary_system0.71109080
54MP0001851_eye_inflammation0.70514986
55MP0001286_abnormal_eye_development0.70458524
56MP0006276_abnormal_autonomic_nervous0.68870788
57MP0002064_seizures0.68086521
58MP0001485_abnormal_pinna_reflex0.67095843
59MP0003303_peritoneal_inflammation0.66880455
60MP0003567_abnormal_fetal_cardiomyocyte0.64786524
61MP0002332_abnormal_exercise_endurance0.62678397
62MP0002734_abnormal_mechanical_nocicepti0.61980619
63MP0001661_extended_life_span0.61282515
64MP0002697_abnormal_eye_size0.61142191
65MP0009046_muscle_twitch0.60674371
66MP0001835_abnormal_antigen_presentation0.60114221
67MP0005387_immune_system_phenotype0.59224216
68MP0001790_abnormal_immune_system0.59224216
69MP0001800_abnormal_humoral_immune0.58947843
70MP0003890_abnormal_embryonic-extraembry0.58609883
71MP0000049_abnormal_middle_ear0.57089170
72MP0000465_gastrointestinal_hemorrhage0.55389020
73MP0010030_abnormal_orbit_morphology0.55187990
74MP0009333_abnormal_splenocyte_physiolog0.54644292
75MP0003172_abnormal_lysosome_physiology0.52068185
76MP0002063_abnormal_learning/memory/cond0.51374060
77MP0006035_abnormal_mitochondrial_morpho0.49891374
78MP0002723_abnormal_immune_serum0.48277249
79MP0001340_abnormal_eyelid_morphology0.47698766
80MP0002067_abnormal_sensory_capabilities0.46616446
81MP0003436_decreased_susceptibility_to0.46175399
82MP0005389_reproductive_system_phenotype0.44805534
83MP0002095_abnormal_skin_pigmentation0.44714269
84MP0004510_myositis0.44299075
85MP0001963_abnormal_hearing_physiology0.44235776
86MP0002405_respiratory_system_inflammati0.43976266
87MP0005000_abnormal_immune_tolerance0.43872125
88MP0009745_abnormal_behavioral_response0.43272555
89MP0002148_abnormal_hypersensitivity_rea0.43230141
90MP0008007_abnormal_cellular_replicative0.43167514
91MP0004924_abnormal_behavior0.43092144
92MP0005386_behavior/neurological_phenoty0.43092144
93MP0002234_abnormal_pharynx_morphology0.42024470
94MP0004742_abnormal_vestibular_system0.41950338
95MP0000778_abnormal_nervous_system0.41094312
96MP0003698_abnormal_male_reproductive0.40853761
97MP0009780_abnormal_chondrocyte_physiolo0.40609952
98MP0003119_abnormal_digestive_system0.40589819
99MP0002420_abnormal_adaptive_immunity0.40331598
100MP0002160_abnormal_reproductive_system0.40275349
101MP0004215_abnormal_myocardial_fiber0.39884070
102MP0001968_abnormal_touch/_nociception0.39778441
103MP0008260_abnormal_autophagy0.38548798
104MP0002184_abnormal_innervation0.38261498
105MP0002572_abnormal_emotion/affect_behav0.38205542
106MP0008873_increased_physiological_sensi0.38181327
107MP0005025_abnormal_response_to0.38167017
108MP0005193_abnormal_anterior_eye0.37963646
109MP0001293_anophthalmia0.36595115
110MP0001819_abnormal_immune_cell0.36454259
111MP0000685_abnormal_immune_system0.36072124
112MP0001905_abnormal_dopamine_level0.35994216
113MP0000631_abnormal_neuroendocrine_gland0.35947141
114MP0002152_abnormal_brain_morphology0.35786364
115MP0002277_abnormal_respiratory_mucosa0.35533988
116MP0001929_abnormal_gametogenesis0.34881201
117MP0000689_abnormal_spleen_morphology0.34529132
118MP0003633_abnormal_nervous_system0.34491132
119MP0004811_abnormal_neuron_physiology0.32553821
120MP0008569_lethality_at_weaning0.32382883
121MP0005376_homeostasis/metabolism_phenot0.31290775
122MP0001915_intracranial_hemorrhage0.31049593
123MP0010386_abnormal_urinary_bladder0.30717695
124MP0004085_abnormal_heartbeat0.30244370
125MP0002066_abnormal_motor_capabilities/c0.29514420
126MP0004782_abnormal_surfactant_physiolog0.28809272
127MP0004043_abnormal_pH_regulation0.27750923
128MP0002102_abnormal_ear_morphology0.27437811
129MP0003632_abnormal_nervous_system0.27170289
130MP0008961_abnormal_basal_metabolism0.26267870
131MP0003631_nervous_system_phenotype0.25387273
132MP0005620_abnormal_muscle_contractility0.24027396
133MP0000955_abnormal_spinal_cord0.23996299
134MP0002092_abnormal_eye_morphology0.23663918
135MP0003705_abnormal_hypodermis_morpholog0.23504979
136MP0001346_abnormal_lacrimal_gland0.23423175
137MP0005595_abnormal_vascular_smooth0.21511438
138MP0001177_atelectasis0.21388516
139MP0002909_abnormal_adrenal_gland0.21206841
140MP0004145_abnormal_muscle_electrophysio0.19953962
141MP0002557_abnormal_social/conspecific_i0.19831986
142MP0003861_abnormal_nervous_system0.19442941
143MP0004142_abnormal_muscle_tone0.19340838
144MP0005257_abnormal_intraocular_pressure0.18869260
145MP0008004_abnormal_stomach_pH0.18380932
146MP0000026_abnormal_inner_ear0.17484303
147MP0003045_fibrosis0.16534875
148MP0005076_abnormal_cell_differentiation0.16128957
149MP0001879_abnormal_lymphatic_vessel0.14213736
150MP0004036_abnormal_muscle_relaxation0.13468924
151MP0000751_myopathy0.13241242
152MP0003283_abnormal_digestive_organ0.13235308
153MP0003943_abnormal_hepatobiliary_system0.12799856

Predicted human phenotypes

RankGene SetZ-score
1Pigmentary retinal degeneration (HP:0001146)9.02898566
2Central scotoma (HP:0000603)8.95381245
3Pendular nystagmus (HP:0012043)8.88709722
4Scotoma (HP:0000575)7.90391753
5Dyschromatopsia (HP:0007641)7.84793034
6Abnormality of macular pigmentation (HP:0008002)7.65952873
7* Chorioretinal atrophy (HP:0000533)7.24955599
8* Abolished electroretinogram (ERG) (HP:0000550)6.84421331
9Decreased central vision (HP:0007663)6.62406495
10Attenuation of retinal blood vessels (HP:0007843)6.61540244
11Posterior subcapsular cataract (HP:0007787)6.41050412
12Macular degeneration (HP:0000608)5.67155610
13Severe visual impairment (HP:0001141)5.61509348
14Vitreoretinal degeneration (HP:0000655)5.57793519
15Increased corneal curvature (HP:0100692)5.49005975
16Keratoconus (HP:0000563)5.49005975
17* Type II diabetes mellitus (HP:0005978)5.35752281
18Cone-rod dystrophy (HP:0000548)5.28131401
19* Photophobia (HP:0000613)5.25094736
20Constricted visual fields (HP:0001133)4.96512910
21Intestinal atresia (HP:0011100)4.23589723
22Choroideremia (HP:0001139)4.08701236
23Retinitis pigmentosa (HP:0000510)4.00725539
24Subcapsular cataract (HP:0000523)3.87803651
25Decreased electroretinogram (ERG) amplitude (HP:0000654)3.65898137
26Progressive visual loss (HP:0000529)3.52484570
27Annular pancreas (HP:0001734)3.52440089
28Asplenia (HP:0001746)3.08306957
29Abnormality of the phalanges of the 2nd finger (HP:0009541)2.99234833
30Reticulocytopenia (HP:0001896)2.87069028
31Retinal atrophy (HP:0001105)2.83162864
32Esophageal atresia (HP:0002032)2.82948209
33Aplasia/Hypoplasia of the spleen (HP:0010451)2.81438646
34Depressed nasal tip (HP:0000437)2.78592010
35Aplasia/Hypoplasia of the sacrum (HP:0008517)2.76748655
36Supernumerary spleens (HP:0009799)2.73925550
3711 pairs of ribs (HP:0000878)2.60953719
38Abnormality of DNA repair (HP:0003254)2.44604103
39Congenital sensorineural hearing impairment (HP:0008527)2.41179295
40* Wide nasal bridge (HP:0000431)2.38590710
41Optic nerve hypoplasia (HP:0000609)2.36369321
42Absent septum pellucidum (HP:0001331)2.30225385
43Tubulointerstitial nephritis (HP:0001970)2.26057682
44Optic disc pallor (HP:0000543)2.20872807
45Difficulty running (HP:0009046)2.19924497
46Abnormality of the septum pellucidum (HP:0007375)2.18957101
47Colon cancer (HP:0003003)2.18285451
48Polar cataract (HP:0010696)2.17702014
49Abnormality of the vocal cords (HP:0008777)2.09133220
50Growth hormone deficiency (HP:0000824)2.06455774
51Chronic hepatic failure (HP:0100626)2.00064134
52Congenital stationary night blindness (HP:0007642)12.4845849
53Absent rod-and cone-mediated responses on ERG (HP:0007688)11.9685517
54Bony spicule pigmentary retinopathy (HP:0007737)10.9428692
55Abnormal rod and cone electroretinograms (HP:0008323)10.6415336
56Interstitial pulmonary disease (HP:0006530)1.95488689
57Gait imbalance (HP:0002141)1.89171921
58Congenital primary aphakia (HP:0007707)1.85905219
59Increased IgM level (HP:0003496)1.82837400
60Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.81734073
61Increased hepatocellular lipid droplets (HP:0006565)1.80772177
62IgM deficiency (HP:0002850)1.78118763
63Pallor (HP:0000980)1.76139433
64Thrombocytosis (HP:0001894)1.76112330
65Abnormality of dental color (HP:0011073)1.76004264
66Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.75929788
67Abnormal pupillary function (HP:0007686)1.69924064
68Partial duplication of thumb phalanx (HP:0009944)1.68604606
69Upper limb muscle weakness (HP:0003484)1.67414525
70Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.63591196
71Nephrogenic diabetes insipidus (HP:0009806)1.62889537
72Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.61820719
73Thyroiditis (HP:0100646)1.61572084
74Horizontal nystagmus (HP:0000666)1.60450495
75Abnormality of the 2nd finger (HP:0004100)1.59838310
76Diaphragmatic weakness (HP:0009113)1.59371032
77Increased intramyocellular lipid droplets (HP:0012240)1.55442564
78Lipid accumulation in hepatocytes (HP:0006561)1.54990019
79Severe Myopia (HP:0011003)1.53213627
80Abnormality of the phalanges of the 5th finger (HP:0004213)1.52252574
81Medial flaring of the eyebrow (HP:0010747)1.51868960
82Gastrointestinal atresia (HP:0002589)1.51501042
83True hermaphroditism (HP:0010459)1.51425779
84Acute lymphatic leukemia (HP:0006721)1.50843244
85Pancreatic fibrosis (HP:0100732)1.50161061
86* Optic atrophy (HP:0000648)1.49690795
87Double outlet right ventricle (HP:0001719)1.49451109
88Congenital malformation of the right heart (HP:0011723)1.49451109
89Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.44765175
903-Methylglutaconic aciduria (HP:0003535)1.44460148
91Poor coordination (HP:0002370)1.42070493
92Missing ribs (HP:0000921)1.41650128
93Limb hypertonia (HP:0002509)1.39114182
94Decreased activity of mitochondrial respiratory chain (HP:0008972)1.35976680
95Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.35976680
96Increased muscle lipid content (HP:0009058)1.33158085
97Short palpebral fissure (HP:0012745)1.32902593
98Concave nail (HP:0001598)1.32434450
99Visual hallucinations (HP:0002367)1.31145397
100IgA deficiency (HP:0002720)1.29942573
101Vaginal atresia (HP:0000148)1.29354882
102Cystic liver disease (HP:0006706)1.28839953
103Sclerocornea (HP:0000647)1.28702227
104Absent thumb (HP:0009777)1.27746793
105Abnormality of the metopic suture (HP:0005556)1.27412935
106Termporal pattern (HP:0011008)1.26875948
107Insidious onset (HP:0003587)1.26875948
108Genital tract atresia (HP:0001827)1.23799399
109Abnormality of iron homeostasis (HP:0011031)1.23230590
110Renal Fanconi syndrome (HP:0001994)1.22894778
111Partial duplication of the phalanx of hand (HP:0009999)1.22665813
112Aplasia/Hypoplasia of the tongue (HP:0010295)1.22518140
113Abnormal mitochondria in muscle tissue (HP:0008316)1.21591145
114Prominent metopic ridge (HP:0005487)1.21364081
115Abnormality of the fovea (HP:0000493)1.21350534
116Poor head control (HP:0002421)1.20672185
117Pancreatic cysts (HP:0001737)1.20248664
118Abnormal hair laboratory examination (HP:0003328)1.18650046
119Supernumerary ribs (HP:0005815)1.18617079
120Abdominal situs inversus (HP:0003363)1.16877931
121Abnormality of abdominal situs (HP:0011620)1.16877931
122Aplasia/Hypoplasia of the lens (HP:0008063)1.15383750
123Epileptic encephalopathy (HP:0200134)1.15158666
124Dysdiadochokinesis (HP:0002075)1.14731387
125Recurrent sinusitis (HP:0011108)1.11467243
126Retinal detachment (HP:0000541)1.11379309
127Aplasia/Hypoplasia of the fovea (HP:0008060)1.11186544
128Hypoplasia of the fovea (HP:0007750)1.11186544
129Febrile seizures (HP:0002373)1.01420610
130Aplasia/Hypoplasia of the macula (HP:0008059)0.98520622
131Chorioretinal coloboma (HP:0000567)0.97882951
132Hypermetropia (HP:0000540)0.97178439
133Abnormality of the lower motor neuron (HP:0002366)0.96802374
134Furrowed tongue (HP:0000221)0.95688940
135Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)0.95569133
136Aplasia/Hypoplasia affecting the retina (HP:0008061)0.93760053
137Astigmatism (HP:0000483)0.86457690
138Truncal ataxia (HP:0002078)0.85964262
139Anophthalmia (HP:0000528)0.84908094
140Progressive cerebellar ataxia (HP:0002073)0.84621879
141Macroorchidism (HP:0000053)0.82246904
142Anencephaly (HP:0002323)0.79809828
143Specific learning disability (HP:0001328)0.79321133
144Prolonged QT interval (HP:0001657)0.78771274
145Supranuclear gaze palsy (HP:0000605)0.77632758
146Left ventricular hypertrophy (HP:0001712)0.76824497
147Genetic anticipation (HP:0003743)0.75802147
148Depression (HP:0000716)0.72488406
149Insomnia (HP:0100785)0.72217721
150Broad foot (HP:0001769)0.70630259
151Asthma (HP:0002099)0.69448436
152Congenital hepatic fibrosis (HP:0002612)0.68118890
153Aqueductal stenosis (HP:0002410)0.68111037
154Decreased testicular size (HP:0008734)0.67740413
155Hypoventilation (HP:0002791)0.66774817
156Abnormality of the fingertips (HP:0001211)0.65486474
157Abnormality of midbrain morphology (HP:0002418)0.64679611
158Molar tooth sign on MRI (HP:0002419)0.64679611
159Septo-optic dysplasia (HP:0100842)0.63682590
160Lymphopenia (HP:0001888)0.63575287
161Postural instability (HP:0002172)0.62458462
162Zonular cataract (HP:0010920)0.61474420
163Abnormality of the parathyroid morphology (HP:0011766)0.59702076
164Intention tremor (HP:0002080)0.58703810
165Postaxial hand polydactyly (HP:0001162)0.58178427
166Corneal dystrophy (HP:0001131)0.57183065
167Generalized myoclonic seizures (HP:0002123)0.57034840
168Abnormality of cells of the lymphoid lineage (HP:0012140)0.56845411

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K103.44381768
2PINK13.29623639
3IRAK23.22012603
4TLK12.85601966
5PBK2.83040137
6BTK2.28316692
7MUSK2.27895455
8TRIB32.24019844
9DYRK32.10740084
10TAOK12.04700945
11GRK110.8639261
12SIK21.95184075
13CAMK1G1.91260378
14EPHB21.90351433
15TXK1.82272436
16TESK21.77548288
17SRPK11.76482013
18CASK1.68654449
19HIPK21.65608556
20PNCK1.64070366
21SGK2231.60277426
22SGK4941.60277426
23PAK61.59340278
24CDK121.58793820
25OBSCN1.58729832
26MATK1.55436872
27ERBB21.53642270
28VRK11.50865295
29ICK1.50187113
30IKBKB1.48998224
31CAMK1D1.47011466
32MARK31.44349438
33BRD41.37638397
34MAP3K61.36674204
35MAP3K41.36124970
36MARK11.35214577
37NEK11.32812522
38PRKCH1.30166477
39ADRBK11.29032471
40MARK21.21769223
41BRAF1.21561836
42SCYL21.20018562
43PRKD31.18500659
44PKN21.17708806
45IRAK31.13764110
46STK381.12282696
47CSNK1D1.11347695
48PIM11.10874281
49RPS6KC11.08121206
50RPS6KL11.08121206
51MAPK121.07878518
52PASK1.07027248
53CLK11.06460980
54MAPK71.05796835
55PIM21.02969538
56DYRK1B0.99727296
57BMPR1B0.98637470
58RPS6KA60.96263761
59MAP4K10.95601205
60SGK20.91961316
61WNK10.90496372
62CAMKK10.89796957
63SGK30.89363236
64GRK50.87609969
65DYRK1A0.87252734
66ILK0.86783240
67TAOK20.86762467
68INSRR0.81971390
69BCKDK0.81793122
70TBK10.81696755
71PRKCZ0.80987220
72RPS6KA50.80703443
73MAP4K20.79356532
74SIK10.78112316
75PRKCB0.77869286
76IRAK40.77325665
77RPS6KA40.75023465
78PLK20.73289289
79ZAK0.71838751
80LATS10.70734383
81CSF1R0.70661675
82PRKAA10.69830727
83IKBKE0.67216200
84LCK0.66653761
85MINK10.66214051
86CHUK0.65761616
87ALK0.65178797
88RPS6KA30.64203445
89CDK50.63579969
90SGK10.62473722
91CDK90.62000356
92STK160.61486872
93AURKA0.61126648
94ADRBK20.60275379
95PIK3CA0.59330381
96MAP3K110.59087571
97PRKD20.58689408
98MTOR0.58491868
99SIK30.57738642
100PRKACG0.57601656
101STK110.57528183
102CAMK2D0.57047670
103DAPK10.56429056
104TAOK30.55468701
105CSNK2A20.55309260
106NEK20.55050536
107PLK30.54954250
108NTRK30.54193549
109AKT30.54125926
110GSK3B0.54033219
111MAPK100.51652196
112MAPK140.51413010
113IRAK10.51229228
114ITK0.51028886
115MAPK90.50531965
116FES0.50126794
117MAP2K70.48847227
118MAP2K40.48734904
119NTRK20.48266527
120SYK0.48055566
121RET0.47736429
122PRKDC0.47583192
123MAP3K90.47488777
124DYRK20.47466642
125FRK0.46971409
126CDK30.46946737
127CHEK20.46716698
128BCR0.46689206
129LYN0.46507506
130CAMK40.45391008
131PRKAA20.45149888
132CDK10.43934418
133CAMK2A0.43588573
134CSNK1A1L0.43516849
135CAMK10.43088096
136PRKD10.42333600
137KDR0.42112214
138MKNK20.41626202
139CSNK1G20.41433298
140CDC42BPA0.40504329
141DAPK30.39697655
142RIPK10.39031396
143MAP3K70.38993226
144PAK30.38274400
145CSNK1E0.37794537
146PRKCD0.36889257
147KSR10.36683755
148FGFR20.36126349
149PHKG10.35504170
150PHKG20.35504170
151CSK0.35483286
152TEC0.34489970
153EIF2AK10.33487668
154PRKCG0.33219520
155PRPF4B0.32688413
156FYN0.32378950
157TESK10.32277646
158GSK3A0.32183645
159ERN10.31833905
160MAPK80.31784484
161AKT20.31775780
162BLK0.31772953
163CDK190.31580048
164PKN10.31160249
165PRKACA0.30219357
166WNK40.29739554
167CDK150.25929875
168ATM0.24755702

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.13575799
2Systemic lupus erythematosus_Homo sapiens_hsa053222.57638821
3RNA polymerase_Homo sapiens_hsa030202.43876649
4Phototransduction_Homo sapiens_hsa0474415.2480287
5Synaptic vesicle cycle_Homo sapiens_hsa047211.97198093
6Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.71669510
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.70989391
8Olfactory transduction_Homo sapiens_hsa047401.66907698
9Oxidative phosphorylation_Homo sapiens_hsa001901.58067724
10GABAergic synapse_Homo sapiens_hsa047271.48058222
11Taste transduction_Homo sapiens_hsa047421.45698747
12Nitrogen metabolism_Homo sapiens_hsa009101.44722067
13Primary immunodeficiency_Homo sapiens_hsa053401.37476084
14B cell receptor signaling pathway_Homo sapiens_hsa046621.35888141
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.25514001
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.24134795
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.22360672
18Homologous recombination_Homo sapiens_hsa034401.16340825
19Pyrimidine metabolism_Homo sapiens_hsa002401.15466504
20Nucleotide excision repair_Homo sapiens_hsa034201.15043835
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.14145874
22Cholinergic synapse_Homo sapiens_hsa047251.08027529
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.02606597
24Transcriptional misregulation in cancer_Homo sapiens_hsa052021.02301694
25Glutamatergic synapse_Homo sapiens_hsa047241.01500588
26Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.01435649
27Circadian entrainment_Homo sapiens_hsa047131.01228872
28Thyroid cancer_Homo sapiens_hsa052160.98533503
29Acute myeloid leukemia_Homo sapiens_hsa052210.97382748
30Parkinsons disease_Homo sapiens_hsa050120.97283351
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.96805280
32Morphine addiction_Homo sapiens_hsa050320.95032954
33Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.93377075
34Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.93025350
35Notch signaling pathway_Homo sapiens_hsa043300.91595141
36Dopaminergic synapse_Homo sapiens_hsa047280.91592176
37Base excision repair_Homo sapiens_hsa034100.90591329
38T cell receptor signaling pathway_Homo sapiens_hsa046600.88766563
39Viral carcinogenesis_Homo sapiens_hsa052030.88084052
40Circadian rhythm_Homo sapiens_hsa047100.86862095
41Retinol metabolism_Homo sapiens_hsa008300.84782122
42RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.84734998
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82757206
44Huntingtons disease_Homo sapiens_hsa050160.80655016
45Apoptosis_Homo sapiens_hsa042100.80526176
46Rheumatoid arthritis_Homo sapiens_hsa053230.78614900
47Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.76139941
48Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.75064213
49Mismatch repair_Homo sapiens_hsa034300.71936334
50RNA degradation_Homo sapiens_hsa030180.71238153
51Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.70727194
52Insulin secretion_Homo sapiens_hsa049110.70462310
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69633167
54Peroxisome_Homo sapiens_hsa041460.68834832
55Serotonergic synapse_Homo sapiens_hsa047260.68261839
56Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.68107054
57Osteoclast differentiation_Homo sapiens_hsa043800.68037108
58Nicotine addiction_Homo sapiens_hsa050330.67922919
59ABC transporters_Homo sapiens_hsa020100.67834784
60cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64094738
61p53 signaling pathway_Homo sapiens_hsa041150.61811400
62Epstein-Barr virus infection_Homo sapiens_hsa051690.61394803
63Butanoate metabolism_Homo sapiens_hsa006500.59406647
64Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.58211258
65Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.57643219
66Hepatitis B_Homo sapiens_hsa051610.56542687
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56200842
68Oxytocin signaling pathway_Homo sapiens_hsa049210.55495028
69mTOR signaling pathway_Homo sapiens_hsa041500.53647470
70Graft-versus-host disease_Homo sapiens_hsa053320.52760075
71Aldosterone synthesis and secretion_Homo sapiens_hsa049250.52570156
72Lysosome_Homo sapiens_hsa041420.51586312
73Measles_Homo sapiens_hsa051620.51491412
74Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50859489
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49855368
76Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49541216
77Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49060772
78Salivary secretion_Homo sapiens_hsa049700.46781733
79cAMP signaling pathway_Homo sapiens_hsa040240.45825186
80Prolactin signaling pathway_Homo sapiens_hsa049170.44359781
81Renin secretion_Homo sapiens_hsa049240.43754372
82Gastric acid secretion_Homo sapiens_hsa049710.43651322
83Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.43313484
84VEGF signaling pathway_Homo sapiens_hsa043700.43016492
85Inositol phosphate metabolism_Homo sapiens_hsa005620.42166814
86PPAR signaling pathway_Homo sapiens_hsa033200.41337196
87Dilated cardiomyopathy_Homo sapiens_hsa054140.41081323
88Long-term potentiation_Homo sapiens_hsa047200.40623655
89Cocaine addiction_Homo sapiens_hsa050300.40388381
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.39995240
91Basal transcription factors_Homo sapiens_hsa030220.39639975
92Cardiac muscle contraction_Homo sapiens_hsa042600.39308524
93Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.38611378
94Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37741151
95Non-homologous end-joining_Homo sapiens_hsa034500.37737084
96Lysine degradation_Homo sapiens_hsa003100.37063865
97Fanconi anemia pathway_Homo sapiens_hsa034600.36966742
98Type II diabetes mellitus_Homo sapiens_hsa049300.36235410
99TNF signaling pathway_Homo sapiens_hsa046680.36136168
100Colorectal cancer_Homo sapiens_hsa052100.35600945
101Amphetamine addiction_Homo sapiens_hsa050310.34751357
102Type I diabetes mellitus_Homo sapiens_hsa049400.33062526
103Jak-STAT signaling pathway_Homo sapiens_hsa046300.32688686
104Herpes simplex infection_Homo sapiens_hsa051680.32635164
105Alzheimers disease_Homo sapiens_hsa050100.31400670
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.31180119
107Glycerolipid metabolism_Homo sapiens_hsa005610.31089756
108Fructose and mannose metabolism_Homo sapiens_hsa000510.30462502
109Bile secretion_Homo sapiens_hsa049760.29830856
110Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29761761
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29541486
112Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.29448232
113Glucagon signaling pathway_Homo sapiens_hsa049220.28656849
114Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.28590977
115Arginine biosynthesis_Homo sapiens_hsa002200.28447785
116Neurotrophin signaling pathway_Homo sapiens_hsa047220.27913137
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.27838542
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.27689004
119Selenocompound metabolism_Homo sapiens_hsa004500.27169700
120Maturity onset diabetes of the young_Homo sapiens_hsa049500.26905636
121Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.26888439
122Alcoholism_Homo sapiens_hsa050340.26760824
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.26543211
124HIF-1 signaling pathway_Homo sapiens_hsa040660.25647001
125Salmonella infection_Homo sapiens_hsa051320.24523951
126DNA replication_Homo sapiens_hsa030300.24494730
127HTLV-I infection_Homo sapiens_hsa051660.24378980
128Purine metabolism_Homo sapiens_hsa002300.24061272
129Tuberculosis_Homo sapiens_hsa051520.23901477
130AMPK signaling pathway_Homo sapiens_hsa041520.23680754
131GnRH signaling pathway_Homo sapiens_hsa049120.22649068
132Autoimmune thyroid disease_Homo sapiens_hsa053200.22151728
133Glioma_Homo sapiens_hsa052140.22116641
134Thyroid hormone synthesis_Homo sapiens_hsa049180.21968791
135Allograft rejection_Homo sapiens_hsa053300.21791504
136Chemokine signaling pathway_Homo sapiens_hsa040620.21668662
137Tight junction_Homo sapiens_hsa045300.21577361
138Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.21043057
139mRNA surveillance pathway_Homo sapiens_hsa030150.20574393
140Caffeine metabolism_Homo sapiens_hsa002320.20445250
141Fatty acid elongation_Homo sapiens_hsa000620.20225883
142Renal cell carcinoma_Homo sapiens_hsa052110.20026460
143Drug metabolism - other enzymes_Homo sapiens_hsa009830.18980415
144Ras signaling pathway_Homo sapiens_hsa040140.18922880
145Vascular smooth muscle contraction_Homo sapiens_hsa042700.17838785
146Phospholipase D signaling pathway_Homo sapiens_hsa040720.17353815
147Choline metabolism in cancer_Homo sapiens_hsa052310.16838717
148Calcium signaling pathway_Homo sapiens_hsa040200.16728715
149Pancreatic secretion_Homo sapiens_hsa049720.16554203
150Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.16515373
151Fatty acid biosynthesis_Homo sapiens_hsa000610.16290414
152MAPK signaling pathway_Homo sapiens_hsa040100.15855723
153Insulin resistance_Homo sapiens_hsa049310.14585765
154Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.14003264
155SNARE interactions in vesicular transport_Homo sapiens_hsa041300.13753381
156Collecting duct acid secretion_Homo sapiens_hsa049660.13374774
157Biosynthesis of amino acids_Homo sapiens_hsa012300.12799623
158Endometrial cancer_Homo sapiens_hsa052130.12603279
159Hippo signaling pathway_Homo sapiens_hsa043900.12056816
160Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.11979320
161Adipocytokine signaling pathway_Homo sapiens_hsa049200.11909648
162Wnt signaling pathway_Homo sapiens_hsa043100.10961634
163ErbB signaling pathway_Homo sapiens_hsa040120.10782633
164Non-small cell lung cancer_Homo sapiens_hsa052230.10631996
165Axon guidance_Homo sapiens_hsa043600.10380102
166Vibrio cholerae infection_Homo sapiens_hsa051100.10179511
167Melanogenesis_Homo sapiens_hsa049160.09674088
168Mineral absorption_Homo sapiens_hsa049780.09610939
169Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.08822750
170Oocyte meiosis_Homo sapiens_hsa041140.08619423
171Endocytosis_Homo sapiens_hsa041440.08393443

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