NRK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The mouse ortholog of this gene encodes a protein kinase required for JNK activation. The encoded protein may be involved in the induction of actin polymerization in late embryogenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to follicle-stimulating hormone (GO:0032354)8.58279265
2glucocorticoid biosynthetic process (GO:0006704)8.39641023
3C21-steroid hormone biosynthetic process (GO:0006700)7.34337018
4glucocorticoid metabolic process (GO:0008211)7.31631107
5estrogen biosynthetic process (GO:0006703)7.21420177
6cellular response to gonadotropin stimulus (GO:0071371)6.96817912
7androgen biosynthetic process (GO:0006702)6.72191636
8negative regulation of complement activation (GO:0045916)6.51916177
9cellular response to antibiotic (GO:0071236)6.44725412
10chondrocyte development (GO:0002063)5.99884263
11cartilage development involved in endochondral bone morphogenesis (GO:0060351)5.45425211
12negative regulation of protein activation cascade (GO:2000258)5.31198506
13negative regulation of smooth muscle cell differentiation (GO:0051151)5.29815884
14response to gonadotropin (GO:0034698)5.25968422
15positive regulation of phosphoprotein phosphatase activity (GO:0032516)5.22279124
16muscle filament sliding (GO:0030049)5.14855850
17actin-myosin filament sliding (GO:0033275)5.14855850
18Leydig cell differentiation (GO:0033327)5.13053244
19response to insecticide (GO:0017085)5.10158141
20collagen fibril organization (GO:0030199)4.85359502
21neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)4.73945791
22short-term memory (GO:0007614)4.70473371
23cellular response to toxic substance (GO:0097237)4.62433719
24C21-steroid hormone metabolic process (GO:0008207)4.60552951
25regulation of transforming growth factor beta2 production (GO:0032909)4.60040452
26skeletal muscle contraction (GO:0003009)4.58592359
27actin-mediated cell contraction (GO:0070252)4.50817043
28positive regulation of glomerulus development (GO:0090193)4.49629083
29regulation of G0 to G1 transition (GO:0070316)4.48169358
30notochord development (GO:0030903)4.43134607
31regulation of glomerulus development (GO:0090192)4.41898152
32embryonic skeletal joint morphogenesis (GO:0060272)4.33827277
33keratan sulfate catabolic process (GO:0042340)4.29714501
34muscle cell fate commitment (GO:0042693)4.19300924
35cellular response to dexamethasone stimulus (GO:0071549)4.18867241
36basement membrane organization (GO:0071711)4.13468267
37endocrine hormone secretion (GO:0060986)4.07449590
38regulation of skeletal muscle contraction (GO:0014819)4.07088354
39positive regulation of male gonad development (GO:2000020)4.05853953
40negative regulation of humoral immune response (GO:0002921)4.01941950
41negative regulation of norepinephrine secretion (GO:0010700)4.01316884
42insulin-like growth factor receptor signaling pathway (GO:0048009)4.00808354
43metanephric epithelium development (GO:0072207)4.00371478
44cellular sodium ion homeostasis (GO:0006883)3.99994587
45hippo signaling (GO:0035329)3.97833599
46cartilage condensation (GO:0001502)3.89873448
47cell aggregation (GO:0098743)3.89873448
48negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.88905200
49response to dexamethasone (GO:0071548)3.84633489
50benzene-containing compound metabolic process (GO:0042537)3.82884254
51metanephric mesenchyme development (GO:0072075)3.80660788
52endothelial cell morphogenesis (GO:0001886)3.74342985
53positive regulation of metanephros development (GO:0072216)3.72947992
54blood vessel maturation (GO:0001955)3.71450421
55mating behavior (GO:0007617)3.71055394
56cellular response to epinephrine stimulus (GO:0071872)3.69546594
57hormone biosynthetic process (GO:0042446)3.69250624
58protein heterotrimerization (GO:0070208)3.67432878
59regulation of female gonad development (GO:2000194)3.66279121
60negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.59342735
61positive regulation of hormone biosynthetic process (GO:0046886)3.55736048
62regulation of male gonad development (GO:2000018)3.50056500
63paraxial mesoderm development (GO:0048339)3.49979600
64cellular response to cadmium ion (GO:0071276)3.48836380
65bone trabecula formation (GO:0060346)3.47403616
66response to methylmercury (GO:0051597)3.42247989
67kidney mesenchyme development (GO:0072074)3.39445706
68collagen metabolic process (GO:0032963)3.39382088
69dopamine biosynthetic process (GO:0042416)3.38740477
70negative regulation of heart rate (GO:0010459)3.38328126
71actin filament-based movement (GO:0030048)3.36851373
72collagen catabolic process (GO:0030574)3.35602556
73positive regulation of nitric-oxide synthase activity (GO:0051000)3.35538214
74gap junction assembly (GO:0016264)3.34865757
75extracellular regulation of signal transduction (GO:1900115)3.34547356
76extracellular negative regulation of signal transduction (GO:1900116)3.34547356
77negative regulation of potassium ion transmembrane transport (GO:1901380)3.34466641
78cell proliferation involved in metanephros development (GO:0072203)3.32217828
79regulation of smooth muscle cell differentiation (GO:0051150)3.32152590
80progesterone metabolic process (GO:0042448)3.31420330
81multicellular organismal movement (GO:0050879)3.30500777
82musculoskeletal movement (GO:0050881)3.30500777
83uterus development (GO:0060065)3.29118239
84gonadal mesoderm development (GO:0007506)3.28161470
85regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.26765814
86positive regulation of hormone metabolic process (GO:0032352)3.24141235
87chondrocyte proliferation (GO:0035988)3.22523915
88ovulation from ovarian follicle (GO:0001542)3.21706265
89sarcomere organization (GO:0045214)3.19992185
90extracellular matrix disassembly (GO:0022617)3.18508607
91gastrulation with mouth forming second (GO:0001702)3.16198978
92response to epinephrine (GO:0071871)3.15336955
93negative regulation of fatty acid transport (GO:2000192)3.14558533
94bundle of His cell to Purkinje myocyte communication (GO:0086069)3.13125186
95placenta development (GO:0001890)3.13045980
96multicellular organismal macromolecule metabolic process (GO:0044259)3.12679218
97exocrine pancreas development (GO:0031017)3.12078715
98mesenchyme morphogenesis (GO:0072132)3.11361008
99endocardial cushion morphogenesis (GO:0003203)3.08830476
100peptidyl-proline hydroxylation (GO:0019511)3.08709862
101positive regulation of chondrocyte differentiation (GO:0032332)3.08692587
102sarcoplasmic reticulum calcium ion transport (GO:0070296)3.07866811
103cell proliferation involved in kidney development (GO:0072111)3.07862210
104endodermal cell differentiation (GO:0035987)3.06420091
105multicellular organismal catabolic process (GO:0044243)3.06317161
106negative regulation of vascular permeability (GO:0043116)3.05069089
107regulation of gonadotropin secretion (GO:0032276)3.04725442
108metanephric nephron tubule development (GO:0072234)3.03982650
109metanephric tubule development (GO:0072170)3.03982650
110positive regulation of cartilage development (GO:0061036)3.03411755
111estrogen metabolic process (GO:0008210)3.03173488
112androgen metabolic process (GO:0008209)3.02347086
113cartilage development (GO:0051216)3.01454762
114negative regulation of systemic arterial blood pressure (GO:0003085)3.01216378
115response to lead ion (GO:0010288)3.00241853
116adrenal gland development (GO:0030325)2.99842708
117positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.98567261
118protein hydroxylation (GO:0018126)2.98038353
119sex differentiation (GO:0007548)2.98029358
120multicellular organismal metabolic process (GO:0044236)2.97922684
121plasma membrane repair (GO:0001778)2.97355085
122glomerular basement membrane development (GO:0032836)2.96979795
123negative regulation of chondrocyte differentiation (GO:0032331)2.96771409
124positive regulation of cardiac muscle hypertrophy (GO:0010613)2.96762196
125positive regulation of muscle hypertrophy (GO:0014742)2.96762196
126striated muscle contraction (GO:0006941)2.96227364
127positive regulation of mesonephros development (GO:0061213)2.95768984
128toxin metabolic process (GO:0009404)2.95338807
129G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.95184259
130ketone biosynthetic process (GO:0042181)2.93702896
131myofibril assembly (GO:0030239)2.93590441
132mesenchymal cell proliferation (GO:0010463)2.92514325
133head development (GO:0060322)2.89396099
134sex determination (GO:0007530)2.89069983
135regulation of cardioblast differentiation (GO:0051890)2.88374436
136neuron projection extension involved in neuron projection guidance (GO:1902284)2.87972708
137axon extension involved in axon guidance (GO:0048846)2.87972708
138endocardial cushion development (GO:0003197)2.87565134
139regulation of tight junction assembly (GO:2000810)2.87416496
140cartilage morphogenesis (GO:0060536)2.87384902
141body morphogenesis (GO:0010171)2.86334320
142regulation of steroid hormone biosynthetic process (GO:0090030)2.85204202
143positive regulation of vasculogenesis (GO:2001214)2.84785830
144regulation of chondrocyte differentiation (GO:0032330)2.84572810
145embryonic foregut morphogenesis (GO:0048617)2.84178935
146cerebellar granule cell differentiation (GO:0021707)2.81131185
147regulation of metanephros development (GO:0072215)2.80563969
148metanephric nephron epithelium development (GO:0072243)2.80533485
149regulation of potassium ion transmembrane transporter activity (GO:1901016)2.79562119
150negative regulation of anoikis (GO:2000811)2.79354782
151neural crest cell development (GO:0014032)2.79160320
152positive regulation of glycogen biosynthetic process (GO:0045725)2.78568690
153cellular response to growth hormone stimulus (GO:0071378)2.76470170
154branching involved in prostate gland morphogenesis (GO:0060442)2.76142859
155labyrinthine layer development (GO:0060711)2.73582993
156collecting duct development (GO:0072044)2.73517158
157limb bud formation (GO:0060174)2.72317185
158negative regulation of protein localization to cell surface (GO:2000009)2.72141418
159cellular response to interferon-alpha (GO:0035457)2.71378737
160heart morphogenesis (GO:0003007)2.71261612
161chondrocyte differentiation (GO:0002062)2.71093192
162cardiac myofibril assembly (GO:0055003)2.69600351
163positive regulation of renal sodium excretion (GO:0035815)2.69599657
164regulation of non-canonical Wnt signaling pathway (GO:2000050)2.68563834
165positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.68547547
166renal filtration (GO:0097205)2.66835853
167branching involved in salivary gland morphogenesis (GO:0060445)2.66646794
168sequestering of extracellular ligand from receptor (GO:0035581)2.66242655
169regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.65967740
170response to vitamin E (GO:0033197)2.65927121
171SMAD protein signal transduction (GO:0060395)2.65812857
172male genitalia development (GO:0030539)2.65658746
173regulation of cartilage development (GO:0061035)2.65418753
174mitotic G2 DNA damage checkpoint (GO:0007095)2.65309704
175positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.64589338
176epithelial cell differentiation involved in kidney development (GO:0035850)2.64531505
177glomerular filtration (GO:0003094)2.64240516
178negative chemotaxis (GO:0050919)2.64200693
179actomyosin structure organization (GO:0031032)2.64004909
180desmosome organization (GO:0002934)2.63933424
181regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.61262972
182mesodermal cell differentiation (GO:0048333)2.59898763
183response to BMP (GO:0071772)2.59015867
184cellular response to BMP stimulus (GO:0071773)2.59015867
185atrioventricular valve morphogenesis (GO:0003181)2.58722531
186positive regulation of extracellular matrix organization (GO:1903055)2.58677651
187negative regulation of catenin import into nucleus (GO:0035414)2.58566258
188substrate adhesion-dependent cell spreading (GO:0034446)2.58086655
189skeletal system development (GO:0001501)2.57853405
190cellular response to follicle-stimulating hormone stimulus (GO:0071372)10.2158342

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.91307561
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.85331027
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.74862576
4GBX2_23144817_ChIP-Seq_PC3_Human3.66360256
5CDX2_19796622_ChIP-Seq_MESCs_Mouse3.30920582
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.05700535
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.92825358
8SALL4_18804426_ChIP-ChIP_XEN_Mouse2.62701379
9RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.62356357
10AR_21572438_ChIP-Seq_LNCaP_Human2.46143532
11VDR_22108803_ChIP-Seq_LS180_Human2.42617987
12TP63_19390658_ChIP-ChIP_HaCaT_Human2.37466051
13ESR1_20079471_ChIP-ChIP_T-47D_Human2.32045039
14WT1_19549856_ChIP-ChIP_CCG9911_Human2.29346097
15TAF15_26573619_Chip-Seq_HEK293_Human2.29294272
16ESR1_21235772_ChIP-Seq_MCF-7_Human2.26537330
17EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.24018601
18HIF1A_21447827_ChIP-Seq_MCF-7_Human2.20344698
19EZH2_22144423_ChIP-Seq_EOC_Human2.19920502
20ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.19566434
21CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.19241452
22PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.08409838
23IGF1R_20145208_ChIP-Seq_DFB_Human2.07996961
24ZFP57_27257070_Chip-Seq_ESCs_Mouse2.04891051
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.03131233
26EP300_21415370_ChIP-Seq_HL-1_Mouse1.99670071
27ISL1_27105846_Chip-Seq_CPCs_Mouse1.98337522
28CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.97162143
29HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.96978173
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.95840305
31* SMAD4_21799915_ChIP-Seq_A2780_Human1.95183952
32POU3F2_20337985_ChIP-ChIP_501MEL_Human1.94656918
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.87822148
34FUS_26573619_Chip-Seq_HEK293_Human1.85335389
35TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.80982032
36EZH2_27304074_Chip-Seq_ESCs_Mouse1.80078584
37EED_16625203_ChIP-ChIP_MESCs_Mouse1.77769712
38WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.76550025
39PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.76187627
40CJUN_26792858_Chip-Seq_BT549_Human1.75586300
41* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.73158460
42CLOCK_20551151_ChIP-Seq_293T_Human1.72731448
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.72493309
44FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.71269817
45ZNF217_24962896_ChIP-Seq_MCF-7_Human1.70617255
46BRD4_25478319_ChIP-Seq_HGPS_Human1.69742344
47OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.68393284
48ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.65361287
49NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.63810860
50P300_19829295_ChIP-Seq_ESCs_Human1.63066208
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.60817566
52ESR2_21235772_ChIP-Seq_MCF-7_Human1.60646179
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.59046228
54TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58554053
55RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.56835518
56RARG_19884340_ChIP-ChIP_MEFs_Mouse1.56371542
57SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.55976792
58KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.55910053
59BCAT_22108803_ChIP-Seq_LS180_Human1.55367434
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55151005
61SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.53086193
62AR_21909140_ChIP-Seq_LNCAP_Human1.51863537
63CTBP2_25329375_ChIP-Seq_LNCAP_Human1.51644386
64* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.46558496
65* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.46558496
66TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.45583391
67TCF4_18268006_ChIP-ChIP_LS174T_Human1.45577336
68TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.45000881
69ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.43426049
70FLI1_27457419_Chip-Seq_LIVER_Mouse1.43279934
71TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42989777
72SMAD_19615063_ChIP-ChIP_OVARY_Human1.42876630
73FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.41948514
74SMAD4_21741376_ChIP-Seq_EPCs_Human1.40422598
75PCGF2_27294783_Chip-Seq_ESCs_Mouse1.39935993
76PCGF2_27294783_Chip-Seq_NPCs_Mouse1.39399049
77JARID2_20064375_ChIP-Seq_MESCs_Mouse1.38930768
78MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.38869990
79SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.38261569
80SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.38261569
81PPAR_26484153_Chip-Seq_NCI-H1993_Human1.36655704
82TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.35931971
83EGR1_19374776_ChIP-ChIP_THP-1_Human1.35800713
84CDX2_20551321_ChIP-Seq_CACO-2_Human1.35343884
85AR_25329375_ChIP-Seq_VCAP_Human1.34179599
86SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.34088893
87LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33788246
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33267559
89RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.32382730
90TCF4_23295773_ChIP-Seq_U87_Human1.31848427
91SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.31617739
92SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.29660399
93EZH2_27294783_Chip-Seq_NPCs_Mouse1.29125652
94CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.27623984
95SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27501784
96CBX2_27304074_Chip-Seq_ESCs_Mouse1.26543403
97SMAD3_21741376_ChIP-Seq_HESCs_Human1.25807929
98STAT3_23295773_ChIP-Seq_U87_Human1.25724351
99ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.24101057
100* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22727147
101NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.20732952
102NRF2_20460467_ChIP-Seq_MEFs_Mouse1.20732952
103EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.20727482
104* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.20365496
105PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.20076764
106NFIB_24661679_ChIP-Seq_LUNG_Mouse1.19424125
107EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17701438
108NANOG_18555785_Chip-Seq_ESCs_Mouse1.16267240
109DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.16181324
110SMAD4_21741376_ChIP-Seq_HESCs_Human1.15849627
111KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15384843
112TCF4_22108803_ChIP-Seq_LS180_Human1.15297136
113* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.14039551
114SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.13601388
115SOX2_20726797_ChIP-Seq_SW620_Human1.13143830
116YAP1_20516196_ChIP-Seq_MESCs_Mouse1.12530564
117RUNX2_22187159_ChIP-Seq_PCA_Human1.12349739
118* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.11601227
119TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10276961
120TP53_18474530_ChIP-ChIP_U2OS_Human1.09376554
121TBX3_20139965_ChIP-Seq_ESCs_Mouse1.08134135
122SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.08114739
123CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07665249
124SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07373977
125TBX3_20139965_ChIP-Seq_MESCs_Mouse1.06432146
126NFE2_27457419_Chip-Seq_LIVER_Mouse1.06289387
127E2F7_22180533_ChIP-Seq_HELA_Human1.05927860
128RNF2_27304074_Chip-Seq_NSC_Mouse1.05645203
129TP53_16413492_ChIP-PET_HCT116_Human1.05568502
130NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05196322
131AHR_22903824_ChIP-Seq_MCF-7_Human1.05010442
132STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.04813024
133RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04753549
134GATA2_21666600_ChIP-Seq_HMVEC_Human1.04309992
135TAL1_26923725_Chip-Seq_HPCs_Mouse1.03434709
136FOXM1_26456572_ChIP-Seq_MCF-7_Human1.03234213
137NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.03222018
138RNF2_27304074_Chip-Seq_ESCs_Mouse1.03038452
139KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.02334306
140CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.02188718
141KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.02155633
142PIAS1_25552417_ChIP-Seq_VCAP_Human1.02124854
143ARNT_22903824_ChIP-Seq_MCF-7_Human1.01532047
144AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99497744
145ZNF274_21170338_ChIP-Seq_K562_Hela0.99148770
146TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99024837
147* EWS_26573619_Chip-Seq_HEK293_Human0.98911745
148TBX20_22328084_ChIP-Seq_HEART_Mouse0.98517277
149TBX20_22080862_ChIP-Seq_HEART_Mouse0.98517277
150SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.98226675
151RING1B_27294783_Chip-Seq_NPCs_Mouse0.97983908
152ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.97704916
153POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97608869
154KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.97170309
155FOXO3_23340844_ChIP-Seq_DLD1_Human0.95489354
156TP53_20018659_ChIP-ChIP_R1E_Mouse0.94990611
157POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93870835
158TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93870835
159WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93044392
160UBF1/2_26484160_Chip-Seq_HMECs_Human0.92874330
161* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.92630156

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting6.30080133
2MP0003123_paternal_imprinting5.19778943
3MP0003121_genomic_imprinting4.48292921
4MP0004272_abnormal_basement_membrane4.36279478
5MP0005503_abnormal_tendon_morphology3.54439951
6MP0006054_spinal_hemorrhage3.40113985
7MP0008438_abnormal_cutaneous_collagen3.12343429
8MP0004264_abnormal_extraembryonic_tissu3.12111025
9MP0000639_abnormal_adrenal_gland3.03999708
10MP0000749_muscle_degeneration2.63733022
11MP0004134_abnormal_chest_morphology2.51188692
12MP0003385_abnormal_body_wall2.34634763
13MP0010386_abnormal_urinary_bladder2.33190825
14MP0001661_extended_life_span2.31513160
15MP0003950_abnormal_plasma_membrane2.25538615
16MP0004036_abnormal_muscle_relaxation2.22139115
17MP0008995_early_reproductive_senescence2.19942636
18MP0002282_abnormal_trachea_morphology2.13957364
19MP0003787_abnormal_imprinting2.07623863
20MP0003705_abnormal_hypodermis_morpholog2.05948760
21MP0002909_abnormal_adrenal_gland2.02388217
22MP0009250_abnormal_appendicular_skeleto2.02186548
23MP0005620_abnormal_muscle_contractility1.92652595
24MP0008877_abnormal_DNA_methylation1.90794498
25MP0009384_cardiac_valve_regurgitation1.90401886
26MP0006276_abnormal_autonomic_nervous1.89221708
27MP0004197_abnormal_fetal_growth/weight/1.87714647
28MP0005275_abnormal_skin_tensile1.87479882
29MP0003941_abnormal_skin_development1.86982776
30MP0005623_abnormal_meninges_morphology1.77838964
31MP0003566_abnormal_cell_adhesion1.72133999
32MP0000163_abnormal_cartilage_morphology1.68994423
33MP0004087_abnormal_muscle_fiber1.67829261
34MP0003567_abnormal_fetal_cardiomyocyte1.67274130
35MP0000537_abnormal_urethra_morphology1.65725229
36MP0002269_muscular_atrophy1.63808810
37MP0000750_abnormal_muscle_regeneration1.63300653
38MP0003942_abnormal_urinary_system1.62832866
39MP0005508_abnormal_skeleton_morphology1.58285704
40MP0002106_abnormal_muscle_physiology1.55399466
41MP0003279_aneurysm1.54102770
42MP0004215_abnormal_myocardial_fiber1.52924474
43MP0009053_abnormal_anal_canal1.52573183
44MP0002837_dystrophic_cardiac_calcinosis1.52265879
45MP0009046_muscle_twitch1.50541783
46MP0002115_abnormal_skeleton_extremities1.50529660
47MP0001984_abnormal_olfaction1.47770241
48MP0004270_analgesia1.45235115
49MP0005369_muscle_phenotype1.42202207
50MP0003937_abnormal_limbs/digits/tail_de1.39990930
51MP0002160_abnormal_reproductive_system1.39699475
52MP0003755_abnormal_palate_morphology1.38854778
53MP0002896_abnormal_bone_mineralization1.38329855
54MP0002938_white_spotting1.38317232
55MP0004084_abnormal_cardiac_muscle1.38166806
56MP0002086_abnormal_extraembryonic_tissu1.37879305
57MP0002113_abnormal_skeleton_development1.36192430
58MP0005187_abnormal_penis_morphology1.34839791
59MP0005076_abnormal_cell_differentiation1.32919303
60MP0003119_abnormal_digestive_system1.31830582
61MP0002109_abnormal_limb_morphology1.31826841
62MP0006035_abnormal_mitochondrial_morpho1.31389764
63MP0003935_abnormal_craniofacial_develop1.30618422
64MP0000762_abnormal_tongue_morphology1.29483321
65MP0000759_abnormal_skeletal_muscle1.28931828
66MP0010030_abnormal_orbit_morphology1.26558339
67MP0000747_muscle_weakness1.25505987
68MP0009697_abnormal_copulation1.23167234
69MP0001270_distended_abdomen1.22980896
70MP0009780_abnormal_chondrocyte_physiolo1.21796667
71MP0001299_abnormal_eye_distance/1.21725947
72MP0002933_joint_inflammation1.20506187
73MP0004742_abnormal_vestibular_system1.19736407
74MP0008775_abnormal_heart_ventricle1.17187269
75MP0001958_emphysema1.15985784
76MP0000767_abnormal_smooth_muscle1.15799295
77MP0003115_abnormal_respiratory_system1.15331757
78MP0000428_abnormal_craniofacial_morphol1.15270024
79MP0000049_abnormal_middle_ear1.14373005
80MP0000534_abnormal_ureter_morphology1.12491846
81MP0000566_synostosis1.12228513
82MP0002163_abnormal_gland_morphology1.11700475
83MP0002116_abnormal_craniofacial_bone1.10857309
84MP0000003_abnormal_adipose_tissue1.08844827
85MP0000432_abnormal_head_morphology1.07479312
86MP0002108_abnormal_muscle_morphology1.07221503
87MP0005595_abnormal_vascular_smooth1.05501466
88MP0000013_abnormal_adipose_tissue1.03963639
89MP0002089_abnormal_postnatal_growth/wei1.03890523
90MP0005248_abnormal_Harderian_gland1.02932303
91MP0003984_embryonic_growth_retardation1.02467366
92MP0002088_abnormal_embryonic_growth/wei1.01903425
93MP0002972_abnormal_cardiac_muscle1.01379339
94MP0004085_abnormal_heartbeat1.01003046
95MP0003091_abnormal_cell_migration1.00154829
96MP0002272_abnormal_nervous_system1.00056361
97MP0002925_abnormal_cardiovascular_devel0.99692981
98MP0000733_abnormal_muscle_development0.99156684
99MP0004484_altered_response_of0.99029761
100MP0000383_abnormal_hair_follicle0.97042883
101MP0001879_abnormal_lymphatic_vessel0.96754211
102MP0005330_cardiomyopathy0.96496017
103MP0005171_absent_coat_pigmentation0.95743354
104MP0003878_abnormal_ear_physiology0.94292358
105MP0005377_hearing/vestibular/ear_phenot0.94292358
106MP0002128_abnormal_blood_circulation0.94238751
107MP0006138_congestive_heart_failure0.94190622
108MP0003137_abnormal_impulse_conducting0.93772869
109MP0010368_abnormal_lymphatic_system0.92930002
110MP0008875_abnormal_xenobiotic_pharmacok0.92915132
111MP0005389_reproductive_system_phenotype0.92807172
112MP0002111_abnormal_tail_morphology0.91519585
113MP0002114_abnormal_axial_skeleton0.90803336
114MP0000516_abnormal_urinary_system0.89885703
115MP0005367_renal/urinary_system_phenotyp0.89885703
116MP0001672_abnormal_embryogenesis/_devel0.88777689
117MP0005380_embryogenesis_phenotype0.88777689
118MP0002249_abnormal_larynx_morphology0.88681327
119MP0002932_abnormal_joint_morphology0.88583905
120MP0001542_abnormal_bone_strength0.88207348
121MP0009703_decreased_birth_body0.85715627
122MP0003315_abnormal_perineum_morphology0.85711408
123MP0003828_pulmonary_edema0.84824532
124MP0000751_myopathy0.83103268
125MP0000538_abnormal_urinary_bladder0.82334335
126MP0002084_abnormal_developmental_patter0.82243799
127MP0003011_delayed_dark_adaptation0.81748258
128MP0005379_endocrine/exocrine_gland_phen0.81041505
129MP0002233_abnormal_nose_morphology0.80803311
130MP0002184_abnormal_innervation0.79945357
131MP0002127_abnormal_cardiovascular_syste0.79732959
132MP0001915_intracranial_hemorrhage0.78603726
133MP0000266_abnormal_heart_morphology0.76980033
134MP0005023_abnormal_wound_healing0.76401678
135MP0010678_abnormal_skin_adnexa0.75274027
136MP0008569_lethality_at_weaning0.75017697
137MP0001697_abnormal_embryo_size0.74883545
138MP0001614_abnormal_blood_vessel0.74343820
139MP0005390_skeleton_phenotype0.73189842
140MP0005385_cardiovascular_system_phenoty0.73114452
141MP0001544_abnormal_cardiovascular_syste0.73114452
142MP0004145_abnormal_muscle_electrophysio0.72835001
143MP0001765_abnormal_ion_homeostasis0.72375718
144MP0005164_abnormal_response_to0.72293732
145MP0000569_abnormal_digit_pigmentation0.71730535
146MP0001286_abnormal_eye_development0.71532230
147MP0010630_abnormal_cardiac_muscle0.69356351
148MP0001486_abnormal_startle_reflex0.69000978
149MP0001440_abnormal_grooming_behavior0.67789612
150MP0002060_abnormal_skin_morphology0.66350290
151MP0000647_abnormal_sebaceous_gland0.64989203
152MP0000462_abnormal_digestive_system0.63418486
153MP0003786_premature_aging0.61012275
154MP0002210_abnormal_sex_determination0.60503884
155MP0002067_abnormal_sensory_capabilities0.56494423
156MP0002697_abnormal_eye_size0.54410469
157MP0001119_abnormal_female_reproductive0.54314999
158MP0000230_abnormal_systemic_arterial0.54280954
159MP0003635_abnormal_synaptic_transmissio0.52875682

Predicted human phenotypes

RankGene SetZ-score
1Round ear (HP:0100830)7.26021007
2Epiphyseal dysplasia (HP:0002656)7.22107347
3Ulnar deviation of the wrist (HP:0003049)6.18839015
4Calcaneovalgus deformity (HP:0001848)5.71787021
5Irregular epiphyses (HP:0010582)5.25578675
6Vitreoretinal degeneration (HP:0000655)5.15831015
7Deformed tarsal bones (HP:0008119)5.15480244
8Hypoplastic ischia (HP:0003175)5.02403753
9Breech presentation (HP:0001623)4.96539350
10Abnormality of the ischium (HP:0003174)4.56405452
11Renal salt wasting (HP:0000127)4.55192705
12Absent phalangeal crease (HP:0006109)4.52136816
13Trismus (HP:0000211)4.47025625
14Aplasia/Hypoplasia of the pubic bone (HP:0009104)4.28771809
15Abnormal sex determination (HP:0012244)4.25343706
16Sex reversal (HP:0012245)4.25343706
17Cupped ribs (HP:0000887)4.23563183
18Gonadal dysgenesis (HP:0000133)4.18134663
19Fetal akinesia sequence (HP:0001989)4.01930398
20Testicular neoplasm (HP:0010788)3.96036385
21Popliteal pterygium (HP:0009756)3.88574490
22Abnormal finger flexion creases (HP:0006143)3.87974250
23Neoplasm of the heart (HP:0100544)3.87650146
24Small epiphyses (HP:0010585)3.86648232
25Nemaline bodies (HP:0003798)3.68648835
26Metatarsus adductus (HP:0001840)3.61566737
27Flat capital femoral epiphysis (HP:0003370)3.60520062
28Hepatoblastoma (HP:0002884)3.58769120
29Malignant hyperthermia (HP:0002047)3.54365731
30Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.54156413
31Abnormal tarsal ossification (HP:0008369)3.53163816
32Neonatal short-limb short stature (HP:0008921)3.52170146
33Metaphyseal dysplasia (HP:0100255)3.39819790
34Delayed epiphyseal ossification (HP:0002663)3.39013902
35Flat acetabular roof (HP:0003180)3.37803888
36Symphalangism affecting the phalanges of the hand (HP:0009773)3.29718844
37Aplasia of the musculature (HP:0100854)3.24567663
38Hypoplastic heart (HP:0001961)3.19547696
39Muscle fiber inclusion bodies (HP:0100299)3.14826122
40Cervical subluxation (HP:0003308)3.11226637
41Mild short stature (HP:0003502)3.10461420
42Protrusio acetabuli (HP:0003179)3.07464048
43Atonic seizures (HP:0010819)3.01695644
44Soft skin (HP:0000977)2.93649108
45Hyperaldosteronism (HP:0000859)2.90551583
46Mesomelia (HP:0003027)2.88521368
47Cutaneous syndactyly (HP:0012725)2.87372753
48Genu varum (HP:0002970)2.86856996
49Abnormality of carpal bone ossification (HP:0006257)2.86481656
50Diastasis recti (HP:0001540)2.85402441
51Osteoarthritis (HP:0002758)2.85233549
52Muscle fiber splitting (HP:0003555)2.84273454
53Premature rupture of membranes (HP:0001788)2.83012858
54Asymmetry of the thorax (HP:0001555)2.82738298
55Abnormal foot bone ossification (HP:0010675)2.80499564
56Metaphyseal cupping (HP:0003021)2.72795431
57Abnormality of the pubic bones (HP:0003172)2.72358567
58Exostoses (HP:0100777)2.70472600
59Abnormal auditory evoked potentials (HP:0006958)2.70236006
60Aortic dissection (HP:0002647)2.67820749
61Type 1 muscle fiber predominance (HP:0003803)2.63356940
62Limited hip movement (HP:0008800)2.61698561
63Broad thumb (HP:0011304)2.61577098
64Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.61217033
65Abnormality of femoral epiphyses (HP:0006499)2.61217033
66Febrile seizures (HP:0002373)2.60070447
67Hip contracture (HP:0003273)2.57880364
68Scanning speech (HP:0002168)2.57634124
69Abnormal hand bone ossification (HP:0010660)2.52431084
70Abnormal ossification of hand bones (HP:0005921)2.50183705
71Abnormal vertebral ossification (HP:0100569)2.49486360
72Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.48898990
73Short 4th metacarpal (HP:0010044)2.48898990
74Shallow orbits (HP:0000586)2.48802257
75Action tremor (HP:0002345)2.46355760
76Fragile skin (HP:0001030)2.46227085
77Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.45693375
78Degeneration of the lateral corticospinal tracts (HP:0002314)2.45693375
79Platyspondyly (HP:0000926)2.44575823
80Relative macrocephaly (HP:0004482)2.44209583
81Impaired vibration sensation in the lower limbs (HP:0002166)2.43701042
82Short 5th finger (HP:0009237)2.43550962
83Broad long bones (HP:0005622)2.41773425
84Flattened epiphyses (HP:0003071)2.41571327
85Broad phalanx (HP:0006009)2.40913791
86Male pseudohermaphroditism (HP:0000037)2.39798906
87Dysmetric saccades (HP:0000641)2.39240598
88Amniotic constriction ring (HP:0009775)2.38080841
89Abnormality of placental membranes (HP:0011409)2.38080841
90Hypoplasia of the uterus (HP:0000013)2.36364859
91Abnormality of the calf musculature (HP:0001430)2.34460574
92Morphological abnormality of the middle ear (HP:0008609)2.33484948
93Abnormality of the phalanges of the 2nd finger (HP:0009541)2.29548750
94Calf muscle hypertrophy (HP:0008981)2.27797521
95Ankle contracture (HP:0006466)2.27110268
96Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.25407424
97Absent epiphyses (HP:0010577)2.25407424
98Atrophic scars (HP:0001075)2.24793272
99Abnormal delivery (HP:0001787)2.23966893
100Abnormality of the epiphysis of the femoral head (HP:0010574)2.23164438
101Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.22247167
102Absent frontal sinuses (HP:0002688)2.20751949
103Mesangial abnormality (HP:0001966)2.19330667
104Broad phalanges of the hand (HP:0009768)2.19270867
105Thin ribs (HP:0000883)2.18164032
106Micromelia (HP:0002983)2.17799695
107Exercise-induced myalgia (HP:0003738)2.16985886
108Broad finger (HP:0001500)2.16954578
109Follicular hyperkeratosis (HP:0007502)2.16618056
110Abnormality of the proximal phalanges of the hand (HP:0009834)2.14438225
111Akinesia (HP:0002304)2.13779150
112Limited elbow extension (HP:0001377)2.13455586
113Hypoplastic left heart (HP:0004383)2.13450225
114Ulnar deviation of finger (HP:0009465)2.10065472
115Gowers sign (HP:0003391)2.07691397
116Wide anterior fontanel (HP:0000260)2.06747748
117Overgrowth (HP:0001548)2.06610847
118Aortic aneurysm (HP:0004942)2.05576658
119Cutaneous finger syndactyly (HP:0010554)2.05504811
120Osteomalacia (HP:0002749)2.05332994
121Sprengel anomaly (HP:0000912)2.04522801
122Coxa vara (HP:0002812)2.04002301
123Tarsal synostosis (HP:0008368)2.03198557
124Nephroblastoma (Wilms tumor) (HP:0002667)2.02860855
125Rhizomelia (HP:0008905)2.02703511
126Thoracolumbar scoliosis (HP:0002944)2.02642256
127Anomalous pulmonary venous return (HP:0010772)2.02464597
128Right ventricular cardiomyopathy (HP:0011663)2.02170728
129Abnormality of the femoral head (HP:0003368)2.01899296
130Embryonal renal neoplasm (HP:0011794)2.00690216
131Selective tooth agenesis (HP:0001592)2.00689196
132Spinal cord compression (HP:0002176)2.00552688
133Distal arthrogryposis (HP:0005684)10.0974793
134Abnormal pancreas size (HP:0012094)1.99820508
135Abnormality of the 4th metacarpal (HP:0010012)1.99152796
136Synostosis involving bones of the lower limbs (HP:0009138)1.98997293
137Synostosis involving bones of the feet (HP:0009140)1.98997293
138Abnormality of the 2nd finger (HP:0004100)1.98176676
139Bladder diverticulum (HP:0000015)1.95520594
140Vertebral clefting (HP:0008428)1.95397307
141Abnormality of incisor morphology (HP:0011063)1.95070343
142Knee flexion contracture (HP:0006380)1.93685334
143Abnormal lung lobation (HP:0002101)1.93249968
144Long clavicles (HP:0000890)1.92719987
145Lumbar hyperlordosis (HP:0002938)1.92674222
146Hypoplastic pelvis (HP:0008839)1.92410966
147Enlarged penis (HP:0000040)1.91692775
148Increased connective tissue (HP:0009025)1.91404899
149Mitral valve prolapse (HP:0001634)1.90581243
150Rimmed vacuoles (HP:0003805)1.90344295
151Muscle hypertrophy of the lower extremities (HP:0008968)1.89596968
152Chin dimple (HP:0010751)1.89440618
153Mildly elevated creatine phosphokinase (HP:0008180)1.89365842
154Wormian bones (HP:0002645)1.89017068
155Arthropathy (HP:0003040)1.88933911
156Fibular hypoplasia (HP:0003038)1.88491408
157Hypokalemic alkalosis (HP:0001949)1.88128684
158Spinal rigidity (HP:0003306)1.87657434
159Germ cell neoplasia (HP:0100728)1.87290320
160Joint laxity (HP:0001388)1.86218301
161Abnormality of the distal phalanx of the thumb (HP:0009617)1.86042978
162Abnormality of the vertebral endplates (HP:0005106)1.85186022
163Abnormality of the calcaneus (HP:0008364)1.84752329
164Broad palm (HP:0001169)1.83923144
165Abnormality of the acetabulum (HP:0003170)1.83819449
166Horizontal nystagmus (HP:0000666)1.83741211
167Neoplasm of the adrenal cortex (HP:0100641)1.83585012
168Aplasia/Hypoplasia involving the musculature (HP:0001460)1.83359754
169Renal duplication (HP:0000075)1.83114768
170Short femoral neck (HP:0100864)1.82943299
171Abnormality of the corticospinal tract (HP:0002492)1.81542477
172Short middle phalanx of finger (HP:0005819)1.81348612
173Bell-shaped thorax (HP:0001591)1.80416605
174Abnormality of the pulmonary veins (HP:0011718)1.80352727
175Pterygium (HP:0001059)1.79616071
176Bicornuate uterus (HP:0000813)1.77692922
177Hyporeflexia of lower limbs (HP:0002600)1.77599074
178Dysdiadochokinesis (HP:0002075)1.76773910
179Adrenal overactivity (HP:0002717)1.76308793
180Female pseudohermaphroditism (HP:0010458)1.74444205
181Sudden death (HP:0001699)1.73870944
182Clitoromegaly (HP:0000057)1.73431622
183Gaze-evoked nystagmus (HP:0000640)1.71062482
184Rocker bottom foot (HP:0001838)1.70874025
185Absence seizures (HP:0002121)1.69264898
186Bilateral microphthalmos (HP:0007633)1.64868343
187Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.64602574

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR25.35458789
2LATS14.33312995
3PIK3CG3.42542318
4MYLK3.17967914
5STK38L3.12337007
6PKN23.05668690
7MAP3K122.80598185
8GRK52.74865882
9MAP3K32.62398238
10TRIB32.52034566
11PDGFRA2.44092647
12PNCK2.33264286
13STK32.21130009
14STK242.17545667
15PTK62.13657399
16TTK2.11664946
17PLK42.09095208
18RPS6KB22.06891506
19SIK12.05057188
20CSNK1G11.88427204
21EPHB21.85171473
22CSNK1G21.76571873
23PRKG21.76450108
24LATS21.74147807
25FER1.72263094
26CDK121.71174062
27FGFR11.53776911
28MST41.52871242
29CSNK1G31.45223540
30PLK21.42563748
31MUSK1.41527255
32NUAK11.41143018
33PINK11.40123092
34NEK91.37636815
35ERBB31.36473582
36PTK21.36149677
37MAP3K91.35780436
38RIPK11.34526978
39MET1.33953066
40TGFBR11.33244391
41BRD41.32372264
42TIE11.32300589
43OBSCN1.27272164
44ROCK11.21495810
45OXSR11.15182539
46STK391.13728158
47AKT21.13258268
48LRRK21.09667383
49STK101.09586097
50PAK41.06574127
51ACVR1B1.03920444
52PRKG11.03243194
53MKNK11.01361835
54CCNB11.00466607
55BRSK20.99735790
56EPHA40.98298792
57MTOR0.98076300
58EIF2AK30.97735923
59CAMK1G0.97250230
60PDGFRB0.96020912
61WNK10.95567955
62LIMK10.94687305
63CDK190.94084558
64PTK2B0.92753238
65CASK0.91891523
66TGFBR20.88581772
67SGK20.88353309
68MKNK20.87152395
69NTRK30.86357395
70MAP3K100.84391251
71TYRO30.83259079
72SCYL20.82325125
73CDC42BPA0.81587056
74PIK3CA0.81304230
75AKT30.80903463
76ERBB40.80771269
77TRPM70.80037006
78CAMK2A0.79594614
79TNIK0.78420892
80CDK70.77349140
81DMPK0.77211965
82PAK20.75277571
83WEE10.74528438
84MOS0.73067430
85PLK30.72457378
86CDK90.72183696
87EEF2K0.71303365
88PAK30.70294391
89FGFR20.68896247
90ERBB20.68605938
91MARK30.66656698
92SGK4940.66016701
93SGK2230.66016701
94FRK0.65410626
95PASK0.65009703
96PRKD30.63889986
97RET0.62829741
98EPHA30.62768413
99WNK40.61958203
100PRKACA0.61243672
101MAPKAPK50.60691341
102CSNK1A1L0.60137409
103KDR0.60135648
104PRKCG0.60057442
105RPS6KA30.59386650
106FLT30.58559873
107ROCK20.58530589
108KSR10.57329593
109MAPK70.55683609
110MAPKAPK30.54944633
111BCR0.54766052
112SGK10.54483860
113MAP3K40.52747809
114AKT10.52166459
115NME10.52144578
116TTN0.52129522
117PHKG10.52080608
118PHKG20.52080608
119CSNK1D0.51846367
120WNK30.51683879
121ILK0.51386559
122TSSK60.50937422
123MAPK120.50750676
124EIF2AK20.49819535
125PRKCI0.49665160
126NEK60.48916760
127PRKDC0.48545870
128SIK30.48222851
129CAMK2G0.47942664
130PRKCA0.47913294
131DAPK30.47758506
132TAF10.47014440
133NLK0.46975404
134RPS6KA20.44525253
135MELK0.43723174
136MAP2K10.43374267
137FGFR30.43046732
138MAPK10.42362379
139ZAK0.41574388
140SRC0.40806012
141MAP3K70.40744283
142NTRK10.40685299
143BMPR1B0.39982792
144MAP3K80.39835695
145GSK3A0.39153096
146IGF1R0.39026901
147INSR0.38749270
148ATM0.38629284
149EPHB10.38029105
150PRKCE0.37367485
151MAPK140.34557660
152ADRBK10.34200202
153CHEK10.32248433
154CDC70.31918045
155MAPK80.31869207
156BMX0.31352966

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.61591765
2Protein digestion and absorption_Homo sapiens_hsa049743.53674196
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.14642272
4Nitrogen metabolism_Homo sapiens_hsa009102.79824713
5Focal adhesion_Homo sapiens_hsa045102.78343552
6Hippo signaling pathway_Homo sapiens_hsa043902.43312578
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.33981390
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.31472549
9Steroid hormone biosynthesis_Homo sapiens_hsa001402.26958066
10Adherens junction_Homo sapiens_hsa045202.20940230
11Steroid biosynthesis_Homo sapiens_hsa001002.10994502
12TGF-beta signaling pathway_Homo sapiens_hsa043502.08510743
13Basal cell carcinoma_Homo sapiens_hsa052172.04471034
14Proteoglycans in cancer_Homo sapiens_hsa052052.00320561
15Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.96046949
16Dilated cardiomyopathy_Homo sapiens_hsa054141.95895252
17Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.93485824
18Hedgehog signaling pathway_Homo sapiens_hsa043401.91809636
19Circadian entrainment_Homo sapiens_hsa047131.85246220
20Salivary secretion_Homo sapiens_hsa049701.79624587
21Small cell lung cancer_Homo sapiens_hsa052221.78782799
22Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.70388279
23Gastric acid secretion_Homo sapiens_hsa049711.67957295
24PI3K-Akt signaling pathway_Homo sapiens_hsa041511.67727500
25Renin secretion_Homo sapiens_hsa049241.61093231
26Cardiac muscle contraction_Homo sapiens_hsa042601.60226076
27Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.59145182
28GABAergic synapse_Homo sapiens_hsa047271.57300915
29Tight junction_Homo sapiens_hsa045301.57269632
30Morphine addiction_Homo sapiens_hsa050321.48948873
31MicroRNAs in cancer_Homo sapiens_hsa052061.44170044
32Taste transduction_Homo sapiens_hsa047421.43979222
33Amoebiasis_Homo sapiens_hsa051461.42315951
34Glutamatergic synapse_Homo sapiens_hsa047241.42005394
35Calcium signaling pathway_Homo sapiens_hsa040201.41021177
36Lysine degradation_Homo sapiens_hsa003101.40064975
37Long-term potentiation_Homo sapiens_hsa047201.39654113
38Ovarian steroidogenesis_Homo sapiens_hsa049131.37764479
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.36768689
40Thyroid cancer_Homo sapiens_hsa052161.36714062
41Nicotine addiction_Homo sapiens_hsa050331.30988691
42Cell cycle_Homo sapiens_hsa041101.29846022
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.29276299
44Prostate cancer_Homo sapiens_hsa052151.27899470
45Axon guidance_Homo sapiens_hsa043601.25635537
46Vitamin digestion and absorption_Homo sapiens_hsa049771.22984055
47Phosphatidylinositol signaling system_Homo sapiens_hsa040701.17817365
48Pathways in cancer_Homo sapiens_hsa052001.15222425
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.12906510
50Leukocyte transendothelial migration_Homo sapiens_hsa046701.11761462
51Regulation of actin cytoskeleton_Homo sapiens_hsa048101.11184018
52Rap1 signaling pathway_Homo sapiens_hsa040151.10535547
53Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.08544174
54AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.08449635
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.05925840
56Wnt signaling pathway_Homo sapiens_hsa043101.04815815
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03759366
58Bile secretion_Homo sapiens_hsa049761.03498220
59Dopaminergic synapse_Homo sapiens_hsa047281.01246467
60Thyroid hormone signaling pathway_Homo sapiens_hsa049191.00787490
61Platelet activation_Homo sapiens_hsa046111.00596730
62Pancreatic secretion_Homo sapiens_hsa049720.99717458
63Cholinergic synapse_Homo sapiens_hsa047250.99171635
64Melanogenesis_Homo sapiens_hsa049160.97477127
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.96416001
66cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95103992
67Serotonergic synapse_Homo sapiens_hsa047260.95023328
68Dorso-ventral axis formation_Homo sapiens_hsa043200.92788906
69Insulin secretion_Homo sapiens_hsa049110.92604026
70Renal cell carcinoma_Homo sapiens_hsa052110.91590517
71Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.90431110
72Thyroid hormone synthesis_Homo sapiens_hsa049180.88302655
73Oxytocin signaling pathway_Homo sapiens_hsa049210.87619330
74Viral myocarditis_Homo sapiens_hsa054160.86598876
75Endometrial cancer_Homo sapiens_hsa052130.85962624
76Propanoate metabolism_Homo sapiens_hsa006400.84484106
77Sulfur metabolism_Homo sapiens_hsa009200.82876569
78HTLV-I infection_Homo sapiens_hsa051660.82605990
79Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.81344571
80Pancreatic cancer_Homo sapiens_hsa052120.80948039
81Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80890859
82N-Glycan biosynthesis_Homo sapiens_hsa005100.80652468
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80014146
84Notch signaling pathway_Homo sapiens_hsa043300.79807420
85Circadian rhythm_Homo sapiens_hsa047100.78664522
86Pyruvate metabolism_Homo sapiens_hsa006200.78333165
87Colorectal cancer_Homo sapiens_hsa052100.78146673
88Central carbon metabolism in cancer_Homo sapiens_hsa052300.77942746
89Melanoma_Homo sapiens_hsa052180.77346053
90Pentose phosphate pathway_Homo sapiens_hsa000300.75460764
91Gap junction_Homo sapiens_hsa045400.75356143
92Renin-angiotensin system_Homo sapiens_hsa046140.73870675
93Mineral absorption_Homo sapiens_hsa049780.73535898
94HIF-1 signaling pathway_Homo sapiens_hsa040660.73120994
95Amphetamine addiction_Homo sapiens_hsa050310.72657902
96Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.71955731
97Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.71196343
98Olfactory transduction_Homo sapiens_hsa047400.70963155
99Ras signaling pathway_Homo sapiens_hsa040140.70713645
100GnRH signaling pathway_Homo sapiens_hsa049120.70476473
101Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.69571032
102Chronic myeloid leukemia_Homo sapiens_hsa052200.68837112
103Long-term depression_Homo sapiens_hsa047300.68784586
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67927474
105FoxO signaling pathway_Homo sapiens_hsa040680.67747613
106Complement and coagulation cascades_Homo sapiens_hsa046100.67541697
107Glioma_Homo sapiens_hsa052140.66621853
108Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64143118
109Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63776400
110Glucagon signaling pathway_Homo sapiens_hsa049220.63733582
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63171548
112Fatty acid elongation_Homo sapiens_hsa000620.62903866
113mTOR signaling pathway_Homo sapiens_hsa041500.60557226
114Protein export_Homo sapiens_hsa030600.60520480
115Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.59390215
116Estrogen signaling pathway_Homo sapiens_hsa049150.59376825
117Bladder cancer_Homo sapiens_hsa052190.59321555
118Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58515415
119Phototransduction_Homo sapiens_hsa047440.57344319
120Prion diseases_Homo sapiens_hsa050200.55731898
121Viral carcinogenesis_Homo sapiens_hsa052030.54884785
122Toxoplasmosis_Homo sapiens_hsa051450.54522341
123Insulin resistance_Homo sapiens_hsa049310.54167597
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.53531014
125mRNA surveillance pathway_Homo sapiens_hsa030150.52756120
126cAMP signaling pathway_Homo sapiens_hsa040240.52126335
127Neurotrophin signaling pathway_Homo sapiens_hsa047220.51178920
128Oocyte meiosis_Homo sapiens_hsa041140.50978537
129RNA transport_Homo sapiens_hsa030130.50472652
130Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50074304
131Alzheimers disease_Homo sapiens_hsa050100.49585208
132Sphingolipid metabolism_Homo sapiens_hsa006000.49232410
133Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47586975
134Vascular smooth muscle contraction_Homo sapiens_hsa042700.46211744
135Malaria_Homo sapiens_hsa051440.44743316
136Basal transcription factors_Homo sapiens_hsa030220.44087605
137Hepatitis B_Homo sapiens_hsa051610.43596301
138Selenocompound metabolism_Homo sapiens_hsa004500.43523951
139Choline metabolism in cancer_Homo sapiens_hsa052310.43046099
140Aldosterone synthesis and secretion_Homo sapiens_hsa049250.42613755
141VEGF signaling pathway_Homo sapiens_hsa043700.41679170
142RNA degradation_Homo sapiens_hsa030180.41268789
143Non-small cell lung cancer_Homo sapiens_hsa052230.39967214
144Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39827784
145beta-Alanine metabolism_Homo sapiens_hsa004100.39672285
146Chemical carcinogenesis_Homo sapiens_hsa052040.37390571
147Arginine and proline metabolism_Homo sapiens_hsa003300.37072036
148AMPK signaling pathway_Homo sapiens_hsa041520.36901046
149Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36368654
150Fatty acid degradation_Homo sapiens_hsa000710.35939645
151Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35244283
152ErbB signaling pathway_Homo sapiens_hsa040120.34984050
153MAPK signaling pathway_Homo sapiens_hsa040100.33436882
154Inositol phosphate metabolism_Homo sapiens_hsa005620.31952460
155Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.29075149
156Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.28995084

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