NRG2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ERBB family of receptors, this protein induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1, another member of the neuregulin family of ligands. The products of these genes mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. This gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. Alternative transcript variants encoding distinct isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)5.70768599
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.63602146
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.49187744
4ionotropic glutamate receptor signaling pathway (GO:0035235)5.37513430
5vocalization behavior (GO:0071625)4.78927491
6glutamate receptor signaling pathway (GO:0007215)4.77382589
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.70280190
8synaptic vesicle maturation (GO:0016188)4.67985736
9sodium ion export (GO:0071436)4.63199979
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.59488543
11cerebellar Purkinje cell differentiation (GO:0021702)4.57747759
12response to pheromone (GO:0019236)4.54414285
13synaptic transmission, glutamatergic (GO:0035249)4.50469778
14cerebellar granule cell differentiation (GO:0021707)4.47808096
15cellular potassium ion homeostasis (GO:0030007)4.39436436
16neurotransmitter secretion (GO:0007269)4.27870130
17G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.26798145
18synaptic vesicle exocytosis (GO:0016079)4.22063734
19regulation of glutamate receptor signaling pathway (GO:1900449)4.20486324
20membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.10740173
21positive regulation of synapse maturation (GO:0090129)4.10514156
22neuronal action potential propagation (GO:0019227)4.08002266
23synaptic vesicle docking involved in exocytosis (GO:0016081)4.04549095
24prepulse inhibition (GO:0060134)4.01150177
25regulation of synaptic vesicle exocytosis (GO:2000300)3.97119320
26glutamate secretion (GO:0014047)3.96756293
27regulation of synapse structural plasticity (GO:0051823)3.96369898
28neuron-neuron synaptic transmission (GO:0007270)3.94567630
29exploration behavior (GO:0035640)3.93247331
30mitochondrion distribution (GO:0048311)3.84316810
31regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.73605812
32gamma-aminobutyric acid transport (GO:0015812)3.73278322
33membrane depolarization during action potential (GO:0086010)3.72920733
34cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.71455206
35long-term memory (GO:0007616)3.66377747
36neurotransmitter-gated ion channel clustering (GO:0072578)3.64914365
37cell differentiation in hindbrain (GO:0021533)3.63696358
38neuron cell-cell adhesion (GO:0007158)3.63248138
39protein localization to synapse (GO:0035418)3.62098342
40establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.61760334
41mitochondrion transport along microtubule (GO:0047497)3.61760334
42establishment of mitochondrion localization (GO:0051654)3.59054333
43cell communication by electrical coupling (GO:0010644)3.56776783
44neuromuscular process controlling posture (GO:0050884)3.55688207
45regulation of synaptic vesicle transport (GO:1902803)3.53239118
46positive regulation of membrane potential (GO:0045838)3.53043794
47mitochondrion localization (GO:0051646)3.51613769
48cellular sodium ion homeostasis (GO:0006883)3.48990227
49neuronal ion channel clustering (GO:0045161)3.47507564
50neuromuscular process controlling balance (GO:0050885)3.42974349
51potassium ion import (GO:0010107)3.41888574
52regulation of excitatory postsynaptic membrane potential (GO:0060079)3.39581103
53auditory behavior (GO:0031223)3.38443770
54gamma-aminobutyric acid signaling pathway (GO:0007214)3.38262439
55regulation of synapse maturation (GO:0090128)3.37449292
56proline transport (GO:0015824)3.37437009
57regulation of voltage-gated calcium channel activity (GO:1901385)3.33843414
58regulation of long-term neuronal synaptic plasticity (GO:0048169)3.33713429
59regulation of synaptic transmission, glutamatergic (GO:0051966)3.30711797
60positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.30653251
61cell migration in hindbrain (GO:0021535)3.30432708
62regulation of neuronal synaptic plasticity (GO:0048168)3.29632687
63regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.22919295
64positive regulation of synaptic transmission, GABAergic (GO:0032230)3.22113828
65dendritic spine morphogenesis (GO:0060997)3.21574520
66regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.19475979
67negative regulation of cytosolic calcium ion concentration (GO:0051481)3.16361583
68striatum development (GO:0021756)3.16023395
69positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.15969204
70positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.14038161
71regulation of postsynaptic membrane potential (GO:0060078)3.13593491
72neurotransmitter transport (GO:0006836)3.13402387
73membrane depolarization (GO:0051899)3.08584944
74glycine transport (GO:0015816)3.07642693
75layer formation in cerebral cortex (GO:0021819)3.06602840
76mechanosensory behavior (GO:0007638)3.06378868
77regulation of neurotransmitter levels (GO:0001505)3.05738497
78G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.02119509
79cerebellar Purkinje cell layer development (GO:0021680)3.01196629
80postsynaptic membrane organization (GO:0001941)2.98791632
81regulation of ARF protein signal transduction (GO:0032012)2.96293531
82melanin metabolic process (GO:0006582)2.95758432
83adult walking behavior (GO:0007628)2.92437688
84urinary tract smooth muscle contraction (GO:0014848)2.89698749
85regulation of NFAT protein import into nucleus (GO:0051532)2.89563220
86transmission of nerve impulse (GO:0019226)2.89421973
87response to auditory stimulus (GO:0010996)2.89401588
88central nervous system projection neuron axonogenesis (GO:0021952)2.88394678
89detection of calcium ion (GO:0005513)2.87231140
90regulation of cellular respiration (GO:0043457)2.86683425
91negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.86558372
92regulation of female receptivity (GO:0045924)2.85413017
93chemosensory behavior (GO:0007635)2.84708594
94positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.84430100
95dendritic spine organization (GO:0097061)2.83882863
96tongue development (GO:0043586)2.83232830
97membrane hyperpolarization (GO:0060081)2.82263897
98activation of protein kinase A activity (GO:0034199)2.81826562
99axon extension (GO:0048675)2.80638064
100peripheral nervous system axon ensheathment (GO:0032292)2.78549242
101myelination in peripheral nervous system (GO:0022011)2.78549242
102positive regulation of dendritic spine morphogenesis (GO:0061003)2.78060898
103membrane repolarization (GO:0086009)2.76883659
104positive regulation of dendritic spine development (GO:0060999)2.76551297
105positive regulation of amine transport (GO:0051954)2.76510128
106regulation of synaptic plasticity (GO:0048167)2.76446034
107long-term synaptic potentiation (GO:0060291)2.75959957
108negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.75882531
109dopamine receptor signaling pathway (GO:0007212)2.75673706
110behavioral response to cocaine (GO:0048148)2.75237466
111melanin biosynthetic process (GO:0042438)2.72616896
112mating behavior (GO:0007617)2.72433839
113myofibril assembly (GO:0030239)2.71632169
114regulation of clathrin-mediated endocytosis (GO:2000369)2.70282679
115synaptic vesicle endocytosis (GO:0048488)2.69450053
116response to misfolded protein (GO:0051788)2.68937842
117regulation of dendritic spine morphogenesis (GO:0061001)2.68736156
118regulation of vesicle fusion (GO:0031338)2.68367583
119synapse assembly (GO:0007416)2.67030779
120positive regulation of neurotransmitter transport (GO:0051590)2.65918191
121axonal fasciculation (GO:0007413)2.65900544
122negative regulation of amino acid transport (GO:0051956)2.65201215
123cardiac myofibril assembly (GO:0055003)2.64922508
124positive regulation of dendrite development (GO:1900006)2.62893804
125neuromuscular process (GO:0050905)2.62508365
126positive regulation of potassium ion transmembrane transport (GO:1901381)2.62443907
127regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.62405033
128regulation of neurotransmitter secretion (GO:0046928)2.62008101
129potassium ion homeostasis (GO:0055075)2.61311485
130negative regulation of synaptic transmission, GABAergic (GO:0032229)2.60703266
131synaptic transmission (GO:0007268)2.59652391
132positive regulation of amino acid transport (GO:0051957)2.59607093
133hemidesmosome assembly (GO:0031581)2.59553190
134learning (GO:0007612)2.59159181
135adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.58254494
136short-term memory (GO:0007614)2.58046622
137behavioral defense response (GO:0002209)2.56450761
138facial nerve structural organization (GO:0021612)2.53334227
139cranial nerve structural organization (GO:0021604)2.51347420
140presynaptic membrane assembly (GO:0097105)2.47687257
141presynaptic membrane organization (GO:0097090)2.45371084
142positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.44617450
143regulation of autophagic vacuole assembly (GO:2000785)2.42239803
144response to parathyroid hormone (GO:0071107)2.36010294
145regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.35701749

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.89354068
2IKZF1_21737484_ChIP-ChIP_HCT116_Human3.46206003
3DROSHA_22980978_ChIP-Seq_HELA_Human3.07070499
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.00619212
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.00081089
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.94029171
7RARB_27405468_Chip-Seq_BRAIN_Mouse2.93737836
8* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.89351101
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.75187869
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.75187869
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.75161781
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.59167966
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.58056548
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.56229035
15GBX2_23144817_ChIP-Seq_PC3_Human2.56206749
16MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.48540754
17* REST_21632747_ChIP-Seq_MESCs_Mouse2.46733756
18ZNF263_19887448_ChIP-Seq_K562_Human2.42895558
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.42352306
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.36483348
21* RNF2_27304074_Chip-Seq_ESCs_Mouse2.30188201
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.28450517
23EZH2_27304074_Chip-Seq_ESCs_Mouse2.24387020
24EZH2_27294783_Chip-Seq_ESCs_Mouse2.24203078
25* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.17600211
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.17174887
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.12834256
28REST_18959480_ChIP-ChIP_MESCs_Mouse2.06493547
29EED_16625203_ChIP-ChIP_MESCs_Mouse2.04247619
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.96548709
31CTCF_27219007_Chip-Seq_Bcells_Human1.91418029
32CBX2_27304074_Chip-Seq_ESCs_Mouse1.86390260
33TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84667639
34SRY_22984422_ChIP-ChIP_TESTIS_Rat1.75181841
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.74284021
36KDM2B_26808549_Chip-Seq_K562_Human1.72286594
37ESR1_15608294_ChIP-ChIP_MCF-7_Human1.70476303
38DNAJC2_21179169_ChIP-ChIP_NT2_Human1.64337362
39STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.63578155
40KDM2B_26808549_Chip-Seq_SUP-B15_Human1.63122032
41GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.59985829
42SMC4_20622854_ChIP-Seq_HELA_Human1.59967307
43P68_20966046_ChIP-Seq_HELA_Human1.59364683
44TET1_21451524_ChIP-Seq_MESCs_Mouse1.57744579
45AR_21572438_ChIP-Seq_LNCaP_Human1.53316782
46UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.50129301
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.50034454
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48649589
49* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.48538181
50* RACK7_27058665_Chip-Seq_MCF-7_Human1.47987430
51WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.45130743
52ZFP281_18757296_ChIP-ChIP_E14_Mouse1.45118466
53* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.43325206
54CTBP2_25329375_ChIP-Seq_LNCAP_Human1.40234355
55RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.36938419
56* RING1B_27294783_Chip-Seq_ESCs_Mouse1.36198962
57KDM2B_26808549_Chip-Seq_DND41_Human1.36065627
58ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.35810830
59MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.35666793
60SA1_27219007_Chip-Seq_ERYTHROID_Human1.34114379
61SCL_19346495_ChIP-Seq_HPC-7_Human1.33012148
62SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.31525460
63ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.31388856
64FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.30436565
65* AR_19668381_ChIP-Seq_PC3_Human1.29682608
66CREB1_26743006_Chip-Seq_LNCaP_Human1.28170651
67KDM2B_26808549_Chip-Seq_JURKAT_Human1.27857347
68THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27237584
69RARG_19884340_ChIP-ChIP_MEFs_Mouse1.26400182
70SMAD4_21799915_ChIP-Seq_A2780_Human1.25119211
71TCF7_22412390_ChIP-Seq_EML_Mouse1.24275883
72* SOX2_21211035_ChIP-Seq_LN229_Gbm1.24027242
73PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23815418
74TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.23463807
75PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.22567456
76SPI1_23127762_ChIP-Seq_K562_Human1.22525675
77* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.22433958
78* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.22361330
79ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.21492649
80CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.21021729
81SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.20945975
82* RING1B_27294783_Chip-Seq_NPCs_Mouse1.19642136
83* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.18147366
84SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.17210322
85TP53_22127205_ChIP-Seq_IMR90_Human1.17203307
86ELK3_25401928_ChIP-Seq_HUVEC_Human1.17183085
87TP63_17297297_ChIP-ChIP_HaCaT_Human1.17130645
88SMAD3_21741376_ChIP-Seq_ESCs_Human1.16078812
89TP53_23651856_ChIP-Seq_MEFs_Mouse1.15994870
90PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.13322296
91TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.12692550
92SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12322143
93CTCF_27219007_Chip-Seq_ERYTHROID_Human1.12250921
94SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12212533
95SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.10877325
96VDR_21846776_ChIP-Seq_THP-1_Human1.10535126
97SMAD_19615063_ChIP-ChIP_OVARY_Human1.10488171
98PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.10035159
99P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08383162
100KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.06140195
101* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.05592056
102LXR_22292898_ChIP-Seq_THP-1_Human1.05550122
103RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04995724
104YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04670843
105AHR_22903824_ChIP-Seq_MCF-7_Human1.04562921
106CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.04232950
107OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.03379216
108SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.02166189
109CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.02013750
110RUNX_20019798_ChIP-Seq_JUKART_Human0.99487160
111ELF1_20517297_ChIP-Seq_JURKAT_Human0.98343478
112NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98334610
113CTBP1_25329375_ChIP-Seq_LNCAP_Human0.98020082
114DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95145935
115CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.95061074
116P53_22127205_ChIP-Seq_FIBROBLAST_Human0.94662217
117OCT4_19829295_ChIP-Seq_ESCs_Human0.94150634
118TP53_16413492_ChIP-PET_HCT116_Human0.93513053
119ESR2_21235772_ChIP-Seq_MCF-7_Human0.92536957
120CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.92415940
121MYC_22102868_ChIP-Seq_BL_Human0.91914169
122* STAT3_23295773_ChIP-Seq_U87_Human0.90302171
123ARNT_22903824_ChIP-Seq_MCF-7_Human0.89690015
124NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.89601983
125* TET1_21490601_ChIP-Seq_MESCs_Mouse0.89491749
126MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88852534
127TP53_20018659_ChIP-ChIP_R1E_Mouse0.88154235
128* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.87804699
129TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.87046241
130NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.86912621
131SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.86803544
132RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.86454607
133RXR_22108803_ChIP-Seq_LS180_Human0.86330891
134KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.85284684
135AR_25329375_ChIP-Seq_VCAP_Human0.84605859
136SMAD3_21741376_ChIP-Seq_EPCs_Human0.84555840
137EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.84312728
138IGF1R_20145208_ChIP-Seq_DFB_Human0.82703541
139ZNF274_21170338_ChIP-Seq_K562_Hela0.81844431
140KLF4_19829295_ChIP-Seq_ESCs_Human0.80689979
141TCF4_23295773_ChIP-Seq_U87_Human0.80453053
142VDR_24763502_ChIP-Seq_THP-1_Human0.79738259

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.23248682
2MP0003635_abnormal_synaptic_transmissio4.02284404
3MP0009046_muscle_twitch3.82060836
4MP0003880_abnormal_central_pattern3.30940251
5MP0001968_abnormal_touch/_nociception3.14173084
6MP0009745_abnormal_behavioral_response3.12923734
7MP0004858_abnormal_nervous_system3.09141442
8MP0000566_synostosis2.94685235
9MP0002063_abnormal_learning/memory/cond2.93947046
10MP0002064_seizures2.92146414
11MP0008569_lethality_at_weaning2.75163239
12MP0002735_abnormal_chemical_nociception2.74246132
13MP0002822_catalepsy2.68351683
14MP0002572_abnormal_emotion/affect_behav2.58681142
15MP0002272_abnormal_nervous_system2.54215697
16MP0005423_abnormal_somatic_nervous2.49838018
17MP0002736_abnormal_nociception_after2.46369374
18MP0001486_abnormal_startle_reflex2.40784550
19MP0004270_analgesia2.07445208
20MP0002067_abnormal_sensory_capabilities2.04616017
21MP0002733_abnormal_thermal_nociception2.01895867
22MP0002184_abnormal_innervation1.97817886
23MP0002734_abnormal_mechanical_nocicepti1.97813644
24MP0001501_abnormal_sleep_pattern1.93367605
25MP0001970_abnormal_pain_threshold1.82725264
26MP0001984_abnormal_olfaction1.75865261
27MP0005623_abnormal_meninges_morphology1.68600051
28MP0001440_abnormal_grooming_behavior1.65676140
29MP0000955_abnormal_spinal_cord1.64265234
30MP0002877_abnormal_melanocyte_morpholog1.63189145
31MP0004811_abnormal_neuron_physiology1.62396235
32MP0002557_abnormal_social/conspecific_i1.60969443
33MP0000537_abnormal_urethra_morphology1.60258439
34MP0004272_abnormal_basement_membrane1.57370728
35MP0001346_abnormal_lacrimal_gland1.54496072
36MP0000749_muscle_degeneration1.50759074
37MP0004145_abnormal_muscle_electrophysio1.50568504
38MP0003879_abnormal_hair_cell1.48975405
39MP0004084_abnormal_cardiac_muscle1.47067692
40MP0004885_abnormal_endolymph1.45356180
41MP0010030_abnormal_orbit_morphology1.44374518
42MP0002249_abnormal_larynx_morphology1.40388578
43MP0005409_darkened_coat_color1.39923914
44MP0001905_abnormal_dopamine_level1.39748039
45MP0003329_amyloid_beta_deposits1.35512696
46MP0004036_abnormal_muscle_relaxation1.33996487
47MP0001986_abnormal_taste_sensitivity1.32488383
48MP0002102_abnormal_ear_morphology1.30432281
49MP0005386_behavior/neurological_phenoty1.29779870
50MP0004924_abnormal_behavior1.29779870
51MP0000569_abnormal_digit_pigmentation1.28135793
52MP0002882_abnormal_neuron_morphology1.26976579
53MP0001188_hyperpigmentation1.26935402
54MP0000462_abnormal_digestive_system1.22745485
55MP0002066_abnormal_motor_capabilities/c1.18106187
56MP0000003_abnormal_adipose_tissue1.14123594
57MP0001502_abnormal_circadian_rhythm1.12630636
58MP0010234_abnormal_vibrissa_follicle1.10279025
59MP0004142_abnormal_muscle_tone1.08947278
60MP0003632_abnormal_nervous_system1.08789961
61MP0001299_abnormal_eye_distance/1.08505109
62MP0003385_abnormal_body_wall1.06824383
63MP0005171_absent_coat_pigmentation1.06586193
64MP0000579_abnormal_nail_morphology1.05523588
65MP0000049_abnormal_middle_ear1.04708554
66MP0005330_cardiomyopathy1.03861340
67MP0002152_abnormal_brain_morphology1.03334517
68MP0003137_abnormal_impulse_conducting1.03070282
69MP0006276_abnormal_autonomic_nervous1.02353669
70MP0002653_abnormal_ependyma_morphology1.01370103
71MP0003136_yellow_coat_color1.01213589
72MP0009780_abnormal_chondrocyte_physiolo1.01083162
73MP0000778_abnormal_nervous_system1.00897148
74MP0005670_abnormal_white_adipose1.00050667
75MP0002089_abnormal_postnatal_growth/wei0.94968240
76MP0003303_peritoneal_inflammation0.94088339
77MP0003315_abnormal_perineum_morphology0.94027920
78MP0004808_abnormal_hematopoietic_stem0.93452495
79MP0005451_abnormal_body_composition0.93229266
80MP0005620_abnormal_muscle_contractility0.91637993
81MP0001529_abnormal_vocalization0.91523074
82MP0002909_abnormal_adrenal_gland0.91411221
83MP0005499_abnormal_olfactory_system0.91063830
84MP0005394_taste/olfaction_phenotype0.91063830
85MP0000751_myopathy0.90782524
86MP0004087_abnormal_muscle_fiber0.89102694
87MP0000026_abnormal_inner_ear0.87055740
88MP0002269_muscular_atrophy0.86709673
89MP0002837_dystrophic_cardiac_calcinosis0.85718699
90MP0003631_nervous_system_phenotype0.84941109
91MP0008874_decreased_physiological_sensi0.84632087
92MP0004215_abnormal_myocardial_fiber0.82850527
93MP0000759_abnormal_skeletal_muscle0.82626224
94MP0003123_paternal_imprinting0.81574487
95MP0008872_abnormal_physiological_respon0.81189840
96MP0003183_abnormal_peptide_metabolism0.80988326
97MP0005645_abnormal_hypothalamus_physiol0.80779436
98MP0003633_abnormal_nervous_system0.77547701
99MP0003634_abnormal_glial_cell0.77149306
100MP0009250_abnormal_appendicular_skeleto0.76391897
101MP0001177_atelectasis0.75585129
102MP0003045_fibrosis0.75260178
103MP0008789_abnormal_olfactory_epithelium0.74961150
104MP0005375_adipose_tissue_phenotype0.73596043
105MP0000733_abnormal_muscle_development0.72732805
106MP0000534_abnormal_ureter_morphology0.72280936
107MP0001727_abnormal_embryo_implantation0.71922619
108MP0003567_abnormal_fetal_cardiomyocyte0.71914169
109MP0002233_abnormal_nose_morphology0.70908003
110MP0008961_abnormal_basal_metabolism0.70838529
111MP0003861_abnormal_nervous_system0.69885765
112MP0005646_abnormal_pituitary_gland0.69018005
113MP0005174_abnormal_tail_pigmentation0.67697277
114MP0005187_abnormal_penis_morphology0.67603365
115MP0005310_abnormal_salivary_gland0.66598347
116MP0004085_abnormal_heartbeat0.66514461
117MP0003172_abnormal_lysosome_physiology0.65541626
118MP0004510_myositis0.64749088
119MP0000747_muscle_weakness0.62212839
120MP0003075_altered_response_to0.61647238
121MP0002069_abnormal_eating/drinking_beha0.61084270
122MP0000631_abnormal_neuroendocrine_gland0.59707955
123MP0004742_abnormal_vestibular_system0.58960683
124MP0000920_abnormal_myelination0.58167112
125MP0010769_abnormal_survival0.57634704
126MP0001348_abnormal_lacrimal_gland0.57225777
127MP0001485_abnormal_pinna_reflex0.55798771
128MP0010768_mortality/aging0.55111936
129MP0001943_abnormal_respiration0.54394583
130MP0002752_abnormal_somatic_nervous0.54309518
131MP0000428_abnormal_craniofacial_morphol0.53912023
132MP0003866_abnormal_defecation0.53807877
133MP0006292_abnormal_olfactory_placode0.52323282
134MP0003938_abnormal_ear_development0.51246349
135MP0005551_abnormal_eye_electrophysiolog0.51227872
136MP0010770_preweaning_lethality0.50665708
137MP0002082_postnatal_lethality0.50665708
138MP0003787_abnormal_imprinting0.50606014
139MP0009672_abnormal_birth_weight0.50066548
140MP0002229_neurodegeneration0.49211517
141MP0002638_abnormal_pupillary_reflex0.48825085

Predicted human phenotypes

RankGene SetZ-score
1Hemiplegia (HP:0002301)4.86024293
2Myokymia (HP:0002411)4.57988893
3Progressive cerebellar ataxia (HP:0002073)4.50085490
4Focal motor seizures (HP:0011153)4.44107703
5Action tremor (HP:0002345)4.34349031
6Focal seizures (HP:0007359)3.85781969
7Visual hallucinations (HP:0002367)3.75785741
8Genetic anticipation (HP:0003743)3.74743993
9Dysmetric saccades (HP:0000641)3.67807638
10Gaze-evoked nystagmus (HP:0000640)3.57258396
11Epileptic encephalopathy (HP:0200134)3.33079885
12Annular pancreas (HP:0001734)3.25402326
13Febrile seizures (HP:0002373)3.21926249
14Amblyopia (HP:0000646)3.17482089
15Neoplasm of the heart (HP:0100544)3.11912532
16Impaired smooth pursuit (HP:0007772)3.09473744
17Neurofibrillary tangles (HP:0002185)3.03987467
18Gastrointestinal stroma tumor (HP:0100723)2.99181872
19Dysdiadochokinesis (HP:0002075)2.94464843
20Truncal ataxia (HP:0002078)2.79684822
21Shallow orbits (HP:0000586)2.78055386
22Depression (HP:0000716)2.77039353
23Abnormality of the parietal bone (HP:0002696)2.75354499
24Abnormality of ocular smooth pursuit (HP:0000617)2.72247701
25Cerebral inclusion bodies (HP:0100314)2.71452964
26Scanning speech (HP:0002168)2.71223828
27Congenital malformation of the right heart (HP:0011723)2.60570043
28Double outlet right ventricle (HP:0001719)2.60570043
29Broad distal phalanx of finger (HP:0009836)2.58540295
30Pointed chin (HP:0000307)2.57587648
31Abnormality of the lower motor neuron (HP:0002366)2.56397279
32Turricephaly (HP:0000262)2.55465823
33Broad-based gait (HP:0002136)2.54006382
34Short 4th metacarpal (HP:0010044)2.48878967
35Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.48878967
36Atonic seizures (HP:0010819)2.45703102
37Hemiparesis (HP:0001269)2.41065263
38Trigonocephaly (HP:0000243)2.40097393
39Midline defect of the nose (HP:0004122)2.37214360
40Alacrima (HP:0000522)2.33191078
41Hypoventilation (HP:0002791)2.31101313
42Acute lymphatic leukemia (HP:0006721)2.30927917
43Poor eye contact (HP:0000817)2.30734747
44Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.29711152
45Stereotypic behavior (HP:0000733)2.26904105
46Dysmetria (HP:0001310)2.26815432
47Papilledema (HP:0001085)2.26438255
48Diplopia (HP:0000651)2.25252249
49Abnormality of binocular vision (HP:0011514)2.25252249
50Cerebral hypomyelination (HP:0006808)2.22532164
51Supranuclear gaze palsy (HP:0000605)2.21915559
52Foot dorsiflexor weakness (HP:0009027)2.19661072
53Abnormality of the diencephalon (HP:0010662)2.18379704
54Abnormal eating behavior (HP:0100738)2.18051539
55Ventricular fibrillation (HP:0001663)2.18018876
56Overriding aorta (HP:0002623)2.17988246
57Aplasia involving bones of the extremities (HP:0009825)2.15404623
58Aplasia involving bones of the upper limbs (HP:0009823)2.15404623
59Aplasia of the phalanges of the hand (HP:0009802)2.15404623
60Aqueductal stenosis (HP:0002410)2.10231977
61Limb dystonia (HP:0002451)2.09860100
62Limb ataxia (HP:0002070)2.09620957
63Impaired social interactions (HP:0000735)2.09223356
64Abnormal social behavior (HP:0012433)2.09223356
65Short nail (HP:0001799)2.09172106
66Generalized tonic-clonic seizures (HP:0002069)2.08230474
67Short phalanx of the thumb (HP:0009660)2.06263280
68Absence seizures (HP:0002121)2.06081259
69Ankle clonus (HP:0011448)2.05818122
70Obstructive sleep apnea (HP:0002870)2.05617507
71Hyperacusis (HP:0010780)2.05026579
72Urinary urgency (HP:0000012)2.03985589
73Cerebral aneurysm (HP:0004944)2.03658824
74Scapular winging (HP:0003691)2.01129876
75Postural instability (HP:0002172)2.00217512
76Mutism (HP:0002300)1.99581447
77Abnormality of the foot musculature (HP:0001436)1.99565419
78Abnormal connection of the cardiac segments (HP:0011545)1.98983220
79Abnormal ventriculo-arterial connection (HP:0011563)1.98983220
80Transposition of the great arteries (HP:0001669)1.98983220
81Urinary bladder sphincter dysfunction (HP:0002839)1.98839215
82Hyporeflexia of lower limbs (HP:0002600)1.98153865
83Down-sloping shoulders (HP:0200021)1.97752138
84Exercise-induced myalgia (HP:0003738)1.95905744
85Lower limb asymmetry (HP:0100559)1.94175436
86Intention tremor (HP:0002080)1.92665716
87Neoplasm of the oral cavity (HP:0100649)1.92656932
88Chronic otitis media (HP:0000389)1.92479765
89Insomnia (HP:0100785)1.92007010
90Abnormality of the labia minora (HP:0012880)1.91581953
91Decreased lacrimation (HP:0000633)1.90938579
92Abnormality of the periventricular white matter (HP:0002518)1.90433460
93Glioma (HP:0009733)1.89288775
94Cerebellar dysplasia (HP:0007033)1.87567867
95Dialeptic seizures (HP:0011146)1.86604727
96Sudden death (HP:0001699)1.86108295
97CNS hypomyelination (HP:0003429)1.84714818
98Shawl scrotum (HP:0000049)1.83363377
99Flat cornea (HP:0007720)1.82541773
100Bradykinesia (HP:0002067)1.82254079
101Bronchomalacia (HP:0002780)1.82052915
102Ependymoma (HP:0002888)1.81655256
103Fetal akinesia sequence (HP:0001989)1.80744644
104Abnormality of saccadic eye movements (HP:0000570)1.80575570
105Resting tremor (HP:0002322)1.80286286
106Spinal canal stenosis (HP:0003416)1.80022154
107Broad metatarsal (HP:0001783)1.79198254
108Hyperparathyroidism (HP:0000843)1.77560628
109Oligodactyly (HP:0012165)1.75120808
110Flattened epiphyses (HP:0003071)1.74322179
111Milia (HP:0001056)1.74036807
112Colitis (HP:0002583)1.73713447
113Spastic gait (HP:0002064)1.73536193
114Adducted thumb (HP:0001181)1.73245935
115Bell-shaped thorax (HP:0001591)1.72880273
116Myotonia (HP:0002486)1.72660133
117Truncus arteriosus (HP:0001660)1.72223763
118Apathy (HP:0000741)1.71418745
119Peripheral hypomyelination (HP:0007182)1.71080998
120Abnormality of the ischium (HP:0003174)1.70948533
121Overlapping toe (HP:0001845)1.70676973
122Ulnar bowing (HP:0003031)1.68535367
123Anxiety (HP:0000739)1.67449961
124Megalencephaly (HP:0001355)1.67154086
125Tracheomalacia (HP:0002779)1.66837247
126Testicular neoplasm (HP:0010788)1.66731589
127Torticollis (HP:0000473)1.65750990
128Amyotrophic lateral sclerosis (HP:0007354)1.65139011
129Elfin facies (HP:0004428)1.64998118
130Obsessive-compulsive behavior (HP:0000722)1.64693751
131Horizontal nystagmus (HP:0000666)1.64682107
132Adrenal overactivity (HP:0002717)1.64211790
133Posterior embryotoxon (HP:0000627)1.63196869
134Hypoplasia of the iris (HP:0007676)1.62672290
135Neuroectodermal neoplasm (HP:0030061)1.62618783
136Neuroepithelial neoplasm (HP:0030063)1.62618783
137Nervous tissue neoplasm (HP:0030060)1.62618783
138Supernumerary nipples (HP:0002558)1.62589605
139Morphological abnormality of the inner ear (HP:0011390)1.62560920
140Hypercortisolism (HP:0001578)1.61908414
141Coronal craniosynostosis (HP:0004440)1.61811064
142Epileptiform EEG discharges (HP:0011182)1.61514729
143Supraventricular tachycardia (HP:0004755)1.60005647
144Spinal cord compression (HP:0002176)1.59590115
145Sleep apnea (HP:0010535)1.59247221
146Hypoplasia of the brainstem (HP:0002365)1.59157242
147Aplasia/Hypoplasia of the brainstem (HP:0007362)1.59157242
148EMG: myopathic abnormalities (HP:0003458)1.58524792
149Clumsiness (HP:0002312)1.58420673
150Hypoplastic nipples (HP:0002557)1.57675768
151Attention deficit hyperactivity disorder (HP:0007018)1.56969747
152Toxemia of pregnancy (HP:0100603)1.56742823
153Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.54193480
154Spastic tetraparesis (HP:0001285)1.54140498
155EEG with generalized epileptiform discharges (HP:0011198)1.53737470
156Supraventricular arrhythmia (HP:0005115)1.52502979
157Bundle branch block (HP:0011710)1.52419533

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.94593563
2NTRK33.69267993
3EPHA43.43940700
4CAMKK23.05982439
5CAMKK12.69349726
6ICK2.63416639
7FES2.62525000
8NTRK22.31562274
9TNIK2.13447078
10SIK22.08825570
11EEF2K2.04183107
12DAPK22.04169581
13MAP3K41.95119485
14MINK11.83923157
15PKN21.81485027
16MARK11.80978947
17RIPK41.76831419
18KSR21.72342538
19ARAF1.65617343
20MAP3K131.65176129
21TNK21.64103058
22MAP2K71.58484696
23PAK61.55518545
24ALK1.53243842
25MAPK131.52348430
26STK381.45177445
27MAPK121.44362043
28CDK191.42201535
29TAOK11.40377334
30PKN11.39251034
31IRAK31.37758983
32PNCK1.37212667
33SCYL21.36858824
34RIPK11.35351094
35NME21.28929011
36CAMK11.26285598
37LATS21.25445474
38CDK51.24794503
39RPS6KA21.24354810
40SGK31.19123192
41MAP2K41.18898187
42DDR21.18025908
43TAOK31.14896922
44TYRO31.11477918
45DAPK31.11041089
46MARK21.10936067
47PIM21.09167427
48MAPK151.08673359
49MOS1.08387931
50SGK21.04907082
51LMTK21.03648775
52CAMK41.03604094
53RAF11.03413514
54DAPK11.02420270
55PRPF4B0.99269537
56RET0.98524039
57CDK120.98313079
58SIK10.97014536
59NTRK10.95656302
60PHKG20.93002762
61PHKG10.93002762
62PDK10.92423683
63BTK0.92096125
64OBSCN0.89470678
65PRKD30.88884662
66PRKCG0.86304101
67KSR10.83714427
68STK110.82419469
69AKT20.80738741
70CAMK1G0.79878297
71PTK20.79169213
72MAP2K30.79150291
73TLK10.75525437
74TRIB30.74483056
75SMG10.73578394
76RPS6KA50.72794975
77MAP3K70.72601053
78IRAK20.72214585
79ILK0.71503695
80SGK4940.71098060
81SGK2230.71098060
82MATK0.69393146
83ROCK20.69315133
84MAP3K10.67812555
85GRK50.66623294
86EPHA20.66587818
87PRKCH0.66320202
88CDK80.66142902
89SGK10.65984231
90MTOR0.64826543
91BRAF0.64783451
92SYK0.63700508
93PDGFRA0.63279656
94UHMK10.62365648
95RPS6KL10.61136573
96RPS6KC10.61136573
97PTK60.59981193
98CDK30.59749031
99PDPK10.59379745
100CDK150.59016780
101PRKD20.58068241
102RPS6KA60.56884482
103CDK11A0.56029598
104EPHB20.55342038
105CDK180.54383390
106DYRK1A0.54142225
107FYN0.53421627
108BMX0.51977432
109AKT30.51846491
110PTK2B0.51768493
111HCK0.51159904
112TEC0.50866361
113AURKA0.50585881
114MAP4K10.50515655
115NEK20.50033869
116PRKAA10.48560569
117HIPK20.48158911
118WNK10.48126777
119FGFR20.47415050
120CDK40.46773723
121RPS6KA30.46581495
122MAP3K120.46389710
123CASK0.45101399
124DMPK0.44900551
125PAK10.44829318
126MAPK100.44659551
127CSNK1A1L0.44180361
128CAMK2G0.43633905
129CAMK2B0.43014030
130BRD40.42026213
131ROCK10.41437965
132TESK10.40858306
133TAOK20.39995764
134MAPK80.37915680
135CDK140.37732485
136CDC42BPA0.36159653
137PRKCB0.36157841
138PINK10.35371398
139MAP2K60.33534470
140JAK20.33278684
141CSNK1G20.32873782
142EPHB10.32809975
143PRKCI0.32575151
144MAPK90.32324458
145CAMK2A0.30548512
146PRKDC0.30451819

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.42693891
2Long-term potentiation_Homo sapiens_hsa047202.56963233
3Synaptic vesicle cycle_Homo sapiens_hsa047212.51806398
4Circadian entrainment_Homo sapiens_hsa047132.47859924
5Glutamatergic synapse_Homo sapiens_hsa047242.36835853
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.23783415
7Olfactory transduction_Homo sapiens_hsa047402.19990359
8Morphine addiction_Homo sapiens_hsa050322.12779349
9GABAergic synapse_Homo sapiens_hsa047272.11932007
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.06150642
11Amphetamine addiction_Homo sapiens_hsa050312.03623131
12Dopaminergic synapse_Homo sapiens_hsa047281.83887921
13Salivary secretion_Homo sapiens_hsa049701.82830456
14Sulfur relay system_Homo sapiens_hsa041221.82584873
15Cholinergic synapse_Homo sapiens_hsa047251.78779360
16Long-term depression_Homo sapiens_hsa047301.75192459
17Cocaine addiction_Homo sapiens_hsa050301.63307943
18Cardiac muscle contraction_Homo sapiens_hsa042601.63281335
19Taste transduction_Homo sapiens_hsa047421.63151437
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.62683832
21Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.49839357
22Prion diseases_Homo sapiens_hsa050201.49239435
23Gastric acid secretion_Homo sapiens_hsa049711.46776794
24Calcium signaling pathway_Homo sapiens_hsa040201.42426769
25Oxytocin signaling pathway_Homo sapiens_hsa049211.42369935
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.41025951
27Type II diabetes mellitus_Homo sapiens_hsa049301.39619421
28Insulin secretion_Homo sapiens_hsa049111.36259045
29Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.35414895
30cAMP signaling pathway_Homo sapiens_hsa040241.34870176
31Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.29255752
32Phosphatidylinositol signaling system_Homo sapiens_hsa040701.28277157
33Renin secretion_Homo sapiens_hsa049241.27270536
34Vitamin B6 metabolism_Homo sapiens_hsa007501.24414486
35GnRH signaling pathway_Homo sapiens_hsa049121.24310412
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.21240874
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.20623827
38Estrogen signaling pathway_Homo sapiens_hsa049151.19366699
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.19321914
40Hippo signaling pathway_Homo sapiens_hsa043901.11378151
41Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.10550602
42Neurotrophin signaling pathway_Homo sapiens_hsa047221.04582733
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.02792589
44Carbohydrate digestion and absorption_Homo sapiens_hsa049731.02626288
45Gap junction_Homo sapiens_hsa045401.01882672
46cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00238055
47Serotonergic synapse_Homo sapiens_hsa047260.99629050
48Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.99490801
49Systemic lupus erythematosus_Homo sapiens_hsa053220.98482747
50Glioma_Homo sapiens_hsa052140.98469152
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95473333
52Phospholipase D signaling pathway_Homo sapiens_hsa040720.94318265
53Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.92586193
54* ErbB signaling pathway_Homo sapiens_hsa040120.90730086
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.89856836
56Focal adhesion_Homo sapiens_hsa045100.88713682
57Lysine degradation_Homo sapiens_hsa003100.87332892
58MAPK signaling pathway_Homo sapiens_hsa040100.86967146
59Non-small cell lung cancer_Homo sapiens_hsa052230.86180817
60Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.85872629
61Melanogenesis_Homo sapiens_hsa049160.85315594
62Amoebiasis_Homo sapiens_hsa051460.83709110
63Oocyte meiosis_Homo sapiens_hsa041140.81940667
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80099707
65Bile secretion_Homo sapiens_hsa049760.79373767
66AMPK signaling pathway_Homo sapiens_hsa041520.76392739
67Hedgehog signaling pathway_Homo sapiens_hsa043400.76246123
68Thyroid hormone synthesis_Homo sapiens_hsa049180.75992667
69Melanoma_Homo sapiens_hsa052180.75489400
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75463310
71Axon guidance_Homo sapiens_hsa043600.75165645
72Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.73910565
73Central carbon metabolism in cancer_Homo sapiens_hsa052300.73640813
74Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.73639712
75Choline metabolism in cancer_Homo sapiens_hsa052310.70745118
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70449944
77VEGF signaling pathway_Homo sapiens_hsa043700.70447079
78Endometrial cancer_Homo sapiens_hsa052130.69471640
79Rap1 signaling pathway_Homo sapiens_hsa040150.69311853
80Circadian rhythm_Homo sapiens_hsa047100.68586067
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.68564589
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68306336
83Chemokine signaling pathway_Homo sapiens_hsa040620.68272660
84mTOR signaling pathway_Homo sapiens_hsa041500.67969613
85Inositol phosphate metabolism_Homo sapiens_hsa005620.67004675
86Colorectal cancer_Homo sapiens_hsa052100.66494864
87Phenylalanine metabolism_Homo sapiens_hsa003600.65542462
88Chronic myeloid leukemia_Homo sapiens_hsa052200.65439983
89Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.64841032
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63742415
91Acute myeloid leukemia_Homo sapiens_hsa052210.62959453
92Vibrio cholerae infection_Homo sapiens_hsa051100.62827747
93Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.62046124
94Notch signaling pathway_Homo sapiens_hsa043300.61960235
95Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61601643
96B cell receptor signaling pathway_Homo sapiens_hsa046620.61288596
97Wnt signaling pathway_Homo sapiens_hsa043100.60769960
98Glucagon signaling pathway_Homo sapiens_hsa049220.60481425
99Renal cell carcinoma_Homo sapiens_hsa052110.60319849
100Dilated cardiomyopathy_Homo sapiens_hsa054140.58290239
101Ovarian steroidogenesis_Homo sapiens_hsa049130.57518455
102Vascular smooth muscle contraction_Homo sapiens_hsa042700.57038090
103Toxoplasmosis_Homo sapiens_hsa051450.55500702
104Basal cell carcinoma_Homo sapiens_hsa052170.55066675
105Ras signaling pathway_Homo sapiens_hsa040140.54094378
106Pancreatic secretion_Homo sapiens_hsa049720.53522487
107Biosynthesis of amino acids_Homo sapiens_hsa012300.53098263
108Endocytosis_Homo sapiens_hsa041440.52424884
109Platelet activation_Homo sapiens_hsa046110.51719059
110Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.51396285
111Prolactin signaling pathway_Homo sapiens_hsa049170.51284465
112Insulin signaling pathway_Homo sapiens_hsa049100.50088586
113Alcoholism_Homo sapiens_hsa050340.49261673
114Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49107753
115Small cell lung cancer_Homo sapiens_hsa052220.48334926
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48215003
117Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.47697744
118Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47568427
119Arginine and proline metabolism_Homo sapiens_hsa003300.47139985
120Osteoclast differentiation_Homo sapiens_hsa043800.47015618
121Collecting duct acid secretion_Homo sapiens_hsa049660.46652913
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.46055247
123Pathways in cancer_Homo sapiens_hsa052000.44912493
124Tight junction_Homo sapiens_hsa045300.42027641
125Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40518868
126Folate biosynthesis_Homo sapiens_hsa007900.39220893
127Dorso-ventral axis formation_Homo sapiens_hsa043200.37903288

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