NRARP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromosome condensation (GO:0030261)6.94512666
2DNA packaging (GO:0006323)6.46945451
3molting cycle (GO:0042303)5.65827853
4hair cycle (GO:0042633)5.65827853
5desmosome organization (GO:0002934)5.56353035
6sperm capacitation (GO:0048240)5.44960081
7keratinization (GO:0031424)5.01704233
8acrosome reaction (GO:0007340)4.94209879
9cranial nerve morphogenesis (GO:0021602)4.80977226
10hemidesmosome assembly (GO:0031581)4.73546595
11lymph vessel development (GO:0001945)4.69539314
12outer ear morphogenesis (GO:0042473)4.68823330
13planar cell polarity pathway involved in neural tube closure (GO:0090179)4.47761905
14endocardial cushion morphogenesis (GO:0003203)4.47420417
15sperm motility (GO:0030317)4.45252552
16outflow tract septum morphogenesis (GO:0003148)4.40812040
17response to pheromone (GO:0019236)4.35777773
18atrioventricular valve morphogenesis (GO:0003181)4.18284578
19regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.14978087
20establishment of tissue polarity (GO:0007164)4.11430347
21establishment of planar polarity (GO:0001736)4.11430347
22heterochromatin organization (GO:0070828)4.06135772
23tooth mineralization (GO:0034505)4.05570560
24pattern specification involved in kidney development (GO:0061004)3.99907687
25pharyngeal system development (GO:0060037)3.99880237
26fusion of sperm to egg plasma membrane (GO:0007342)3.96485254
27protein-DNA complex disassembly (GO:0032986)3.93194471
28nucleosome disassembly (GO:0006337)3.93194471
29sexual reproduction (GO:0019953)3.90437085
30establishment of skin barrier (GO:0061436)3.88165629
31bundle of His cell to Purkinje myocyte communication (GO:0086069)3.82946088
32heart valve formation (GO:0003188)3.82852614
33Notch signaling involved in heart development (GO:0061314)3.76820072
34spermatid nucleus differentiation (GO:0007289)3.76329189
35epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.74199939
36microtubule depolymerization (GO:0007019)3.71328733
37regulation of water loss via skin (GO:0033561)3.68487018
38regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.59532073
39mesenchyme morphogenesis (GO:0072132)3.58229975
40spermatid development (GO:0007286)3.57162228
41regulation of apoptotic process involved in morphogenesis (GO:1902337)3.55800028
42cell surface receptor signaling pathway involved in heart development (GO:0061311)3.55061591
43mitotic G1 DNA damage checkpoint (GO:0031571)3.53375048
44embryonic skeletal joint morphogenesis (GO:0060272)3.49329765
45endothelium development (GO:0003158)3.48306871
46regulation of cardioblast proliferation (GO:0003264)3.48269167
47regulation of secondary heart field cardioblast proliferation (GO:0003266)3.48269167
48RNA localization (GO:0006403)3.47585918
49muscle cell fate commitment (GO:0042693)3.46173218
50chromatin silencing (GO:0006342)3.44998512
51regulation of mammary gland epithelial cell proliferation (GO:0033599)3.43119508
52endothelial cell differentiation (GO:0045446)3.41010120
53apoptotic process involved in morphogenesis (GO:0060561)3.37307597
54lateral sprouting from an epithelium (GO:0060601)3.36358544
55negative regulation of inclusion body assembly (GO:0090084)3.35874336
56heart trabecula morphogenesis (GO:0061384)3.35196331
57negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.33579266
58regulation of transcription involved in cell fate commitment (GO:0060850)3.31669901
59intracellular estrogen receptor signaling pathway (GO:0030520)3.30432868
60layer formation in cerebral cortex (GO:0021819)3.28555756
61regulation of mesenchymal cell apoptotic process (GO:2001053)3.27212229
62establishment of apical/basal cell polarity (GO:0035089)3.26453800
63heart valve morphogenesis (GO:0003179)3.26124821
64peptidyl-arginine omega-N-methylation (GO:0035247)3.24617227
65regulation of vasculogenesis (GO:2001212)3.23318719
66negative regulation of catenin import into nucleus (GO:0035414)3.22189197
67mammary gland epithelial cell differentiation (GO:0060644)3.19808307
68G1 DNA damage checkpoint (GO:0044783)3.18254877
69single strand break repair (GO:0000012)3.15634354
70microtubule severing (GO:0051013)3.14869852
71cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.09339053
72convergent extension (GO:0060026)3.09272320
73Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.09265600
74binding of sperm to zona pellucida (GO:0007339)3.06030267
75muscle organ morphogenesis (GO:0048644)3.05582639
76negative regulation of oligodendrocyte differentiation (GO:0048715)3.05294122
77embryonic heart tube development (GO:0035050)3.04938246
78plasma membrane fusion (GO:0045026)3.04687673
79trabecula morphogenesis (GO:0061383)3.04197448
80thyroid gland development (GO:0030878)3.04048492
81protein complex localization (GO:0031503)3.03268891
82non-canonical Wnt signaling pathway (GO:0035567)3.02702104
83branching involved in prostate gland morphogenesis (GO:0060442)3.02371716
84negative regulation of myotube differentiation (GO:0010832)3.02308830
85epidermis development (GO:0008544)3.01560269
86mitotic G1/S transition checkpoint (GO:0044819)3.00686555
87negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.00535884
88dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.98004538
89negative regulation of histone methylation (GO:0031061)2.97983308
90glomerulus development (GO:0032835)2.97758946
91cardiac muscle cell proliferation (GO:0060038)2.97259678
92keratinocyte differentiation (GO:0030216)2.96743065
93intermediate filament organization (GO:0045109)2.95942858
94rRNA methylation (GO:0031167)2.95666903
95regulation of establishment of planar polarity (GO:0090175)2.95331810
96polarized epithelial cell differentiation (GO:0030859)2.94761843
97ectoderm development (GO:0007398)2.94374849
98ventricular trabecula myocardium morphogenesis (GO:0003222)2.93895810
99surfactant homeostasis (GO:0043129)2.92786727
100vascular endothelial growth factor signaling pathway (GO:0038084)2.92690362
101glial cell proliferation (GO:0014009)2.89787990
102sperm-egg recognition (GO:0035036)2.89751912
103artery development (GO:0060840)2.89378533
104lymphangiogenesis (GO:0001946)2.88376442
105negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.87163069
106cochlea morphogenesis (GO:0090103)2.86304855
107DNA unwinding involved in DNA replication (GO:0006268)2.85505780
108DNA conformation change (GO:0071103)2.85331104
109cytoskeletal anchoring at plasma membrane (GO:0007016)2.85280216
110coronary vasculature morphogenesis (GO:0060977)2.84739486
111negative regulation of cell fate specification (GO:0009996)2.83692098
112neuronal stem cell maintenance (GO:0097150)2.82935560
113regulation of inclusion body assembly (GO:0090083)2.82580910
114paraxial mesoderm development (GO:0048339)2.82415876
115viral transcription (GO:0019083)2.82166907
116ephrin receptor signaling pathway (GO:0048013)2.82127075
117hippo signaling (GO:0035329)2.81231688
118cardiac ventricle morphogenesis (GO:0003208)2.79644328
119prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.78211094
120sodium ion export (GO:0071436)2.76722905
121mitotic chromosome condensation (GO:0007076)2.76590448
122multicellular organismal water homeostasis (GO:0050891)2.76097959
123regulation of chromatin binding (GO:0035561)2.75652872
124regulation of cardioblast differentiation (GO:0051890)2.75641979
125cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.74357030
126cell communication involved in cardiac conduction (GO:0086065)2.74171974
127heart trabecula formation (GO:0060347)2.74099187
128motile cilium assembly (GO:0044458)2.73452400
129negative regulation of sodium ion transport (GO:0010766)2.72817118
130positive regulation of catenin import into nucleus (GO:0035413)2.72693717
131vasculogenesis (GO:0001570)2.72025198
132negative regulation of striated muscle cell differentiation (GO:0051154)2.71920565
133regulation of catenin import into nucleus (GO:0035412)2.71913005
134microtubule polymerization or depolymerization (GO:0031109)2.71816672
135epithelial cell fate commitment (GO:0072148)2.71624661
136radial glial cell differentiation (GO:0060019)2.71608273
137cell-substrate junction assembly (GO:0007044)2.71235634
138regulation of NFAT protein import into nucleus (GO:0051532)2.69471469
139endothelial cell chemotaxis (GO:0035767)2.69231189
140notochord development (GO:0030903)2.67203860
141mesenchymal cell development (GO:0014031)2.66439278
142peptide cross-linking (GO:0018149)2.66209104
143embryonic foregut morphogenesis (GO:0048617)2.66201256
144striated muscle cell proliferation (GO:0014855)2.65033730
145somatic stem cell division (GO:0048103)2.63343469
146aorta morphogenesis (GO:0035909)2.63180118
147translational termination (GO:0006415)2.62158421
148peptidyl-arginine methylation (GO:0018216)2.62029945
149peptidyl-arginine N-methylation (GO:0035246)2.62029945
150histone arginine methylation (GO:0034969)2.61640260
151vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.61514336
152gap junction assembly (GO:0016264)2.61287404
153positive regulation of astrocyte differentiation (GO:0048711)2.59643184
154atrial cardiac muscle cell action potential (GO:0086014)2.59510488
155spermatogenesis (GO:0007283)2.58704374
156rRNA modification (GO:0000154)2.58423322
157male gamete generation (GO:0048232)2.57934855
158epidermal cell differentiation (GO:0009913)2.57313175
159establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.56963681
160ventricular septum morphogenesis (GO:0060412)2.56871299
161negative regulation of gene expression, epigenetic (GO:0045814)2.56727252
162negative regulation of glial cell proliferation (GO:0060253)2.56173394
163chemical homeostasis within a tissue (GO:0048875)2.54173417
164regulation of endothelial cell differentiation (GO:0045601)2.53898350
165regulation of heart morphogenesis (GO:2000826)2.53827400
166cardiac epithelial to mesenchymal transition (GO:0060317)2.52763967
167regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.52528489
168cardiac chamber morphogenesis (GO:0003206)2.51998715
169cell communication by electrical coupling (GO:0010644)2.51421661
170G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.51310210
171cell migration involved in sprouting angiogenesis (GO:0002042)2.50550304
172ventricular cardiac muscle cell action potential (GO:0086005)2.46222498
173blood vessel maturation (GO:0001955)2.45948575
174respiratory tube development (GO:0030323)2.44709100
175morphogenesis of an endothelium (GO:0003159)2.44378885
176endothelial tube morphogenesis (GO:0061154)2.44378885
177negative regulation of axon extension involved in axon guidance (GO:0048843)2.42516598
178muscle cell proliferation (GO:0033002)2.42205979
179renal system development (GO:0072001)2.41995316
180hair follicle development (GO:0001942)2.41317188
181morphogenesis of an epithelial sheet (GO:0002011)2.40104554
182* patterning of blood vessels (GO:0001569)2.38705823

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.40567083
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.22677253
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.97476906
4E2F7_22180533_ChIP-Seq_HELA_Human2.80124151
5STAT6_21828071_ChIP-Seq_BEAS2B_Human2.69888757
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.33440977
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.28958946
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.28958946
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.23748447
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.18961210
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.18272637
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.16185674
13EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.15515533
14TP63_19390658_ChIP-ChIP_HaCaT_Human2.15446728
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.14625263
16ZNF263_19887448_ChIP-Seq_K562_Human2.09778425
17MYC_22102868_ChIP-Seq_BL_Human2.09220801
18P68_20966046_ChIP-Seq_HELA_Human2.06438095
19TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.05328997
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.04832375
21ESR2_21235772_ChIP-Seq_MCF-7_Human1.98855376
22RNF2_27304074_Chip-Seq_ESCs_Mouse1.98391767
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.93942676
24CLOCK_20551151_ChIP-Seq_293T_Human1.93678891
25VDR_21846776_ChIP-Seq_THP-1_Human1.89238926
26* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.83991313
27* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.82668875
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.82539373
29* TP53_20018659_ChIP-ChIP_R1E_Mouse1.82123139
30* TET1_21451524_ChIP-Seq_MESCs_Mouse1.81152628
31SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.78567965
32SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.75135871
33PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.73413387
34WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.73356752
35ZFP281_18757296_ChIP-ChIP_E14_Mouse1.72004033
36* EZH2_27294783_Chip-Seq_ESCs_Mouse1.71892208
37SA1_27219007_Chip-Seq_ERYTHROID_Human1.71181712
38* KDM2B_26808549_Chip-Seq_K562_Human1.70556027
39CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.68849599
40HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.68514438
41RING1B_27294783_Chip-Seq_ESCs_Mouse1.67558842
42SOX9_24532713_ChIP-Seq_HFSC_Mouse1.65813756
43ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.65658517
44ELF1_20517297_ChIP-Seq_JURKAT_Human1.65059640
45* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.64894304
46* SMC4_20622854_ChIP-Seq_HELA_Human1.63733488
47MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.63260128
48AR_21572438_ChIP-Seq_LNCaP_Human1.60472786
49ZFP281_27345836_Chip-Seq_ESCs_Mouse1.55459519
50RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.54971601
51* KDM2B_26808549_Chip-Seq_JURKAT_Human1.53199464
52* XRN2_22483619_ChIP-Seq_HELA_Human1.53114957
53KDM2B_26808549_Chip-Seq_DND41_Human1.51119808
54KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.50312068
55MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.50234636
56ESR1_21235772_ChIP-Seq_MCF-7_Human1.49634282
57* RING1B_27294783_Chip-Seq_NPCs_Mouse1.46287821
58RARG_19884340_ChIP-ChIP_MEFs_Mouse1.45518893
59TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.45443377
60* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.44740973
61CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.43277805
62MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.42970548
63EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42587508
64ERG_21242973_ChIP-ChIP_JURKAT_Human1.41878026
65EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.41580388
66* ELK3_25401928_ChIP-Seq_HUVEC_Human1.41158497
67* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.39696763
68UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.39501668
69CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.39140212
70MYC_18555785_ChIP-Seq_MESCs_Mouse1.37771630
71RACK7_27058665_Chip-Seq_MCF-7_Human1.37165444
72ZNF217_24962896_ChIP-Seq_MCF-7_Human1.36741109
73WT1_19549856_ChIP-ChIP_CCG9911_Human1.36089877
74DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.35126557
75PHF8_20622854_ChIP-Seq_HELA_Human1.34907587
76* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.34602514
77KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.34451007
78HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.32766770
79KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.32740424
80KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.31863090
81CTCF_27219007_Chip-Seq_ERYTHROID_Human1.31091408
82BCL6_27268052_Chip-Seq_Bcells_Human1.30520201
83* FOXO3_23340844_ChIP-Seq_DLD1_Human1.30096890
84CBX2_27304074_Chip-Seq_ESCs_Mouse1.29743658
85RUNX1_27514584_Chip-Seq_MCF-7_Human1.29190182
86E2F1_20622854_ChIP-Seq_HELA_Human1.28181885
87FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.26279906
88ESR1_20079471_ChIP-ChIP_T-47D_Human1.24768343
89HIF1A_21447827_ChIP-Seq_MCF-7_Human1.24622054
90BCOR_27268052_Chip-Seq_Bcells_Human1.24495197
91TCF4_18268006_ChIP-ChIP_LS174T_Human1.24199432
92ISL1_27105846_Chip-Seq_CPCs_Mouse1.24140434
93ESR1_15608294_ChIP-ChIP_MCF-7_Human1.24003570
94SA1_27219007_Chip-Seq_Bcells_Human1.23051131
95KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21683611
96CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.20532859
97* LXR_22292898_ChIP-Seq_THP-1_Human1.20166883
98DROSHA_22980978_ChIP-Seq_HELA_Human1.19663337
99* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.18503763
100EZH2_22144423_ChIP-Seq_EOC_Human1.17987420
101DNAJC2_21179169_ChIP-ChIP_NT2_Human1.17773361
102RARA_24833708_ChIP-Seq_LIVER_Mouse1.17417325
103CTCF_20526341_ChIP-Seq_ESCs_Human1.15927298
104SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.15577893
105* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15483132
106SRY_22984422_ChIP-ChIP_TESTIS_Rat1.15418457
107KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15318990
108P300_27058665_Chip-Seq_ZR-75-30cells_Human1.15059761
109KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.14784597
110CTCF_27219007_Chip-Seq_Bcells_Human1.14613415
111FOXP1_21924763_ChIP-Seq_HESCs_Human1.14396463
112SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.14305430
113ATF3_27146783_Chip-Seq_COLON_Human1.13566684
114SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13529228
115ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.13326384
116SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.12254199
117RXR_22108803_ChIP-Seq_LS180_Human1.11798935
118CTCF_21964334_Chip-Seq_Bcells_Human1.11365150
119MYC_19079543_ChIP-ChIP_MESCs_Mouse1.11094654
120CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.10893749
121CDX2_20551321_ChIP-Seq_CACO-2_Human1.10513412
122YY1_22570637_ChIP-Seq_MALME-3M_Human1.09955620
123DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.07103850
124TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.07088171
125TBX20_22080862_ChIP-Seq_HEART_Mouse1.06475418
126TBX20_22328084_ChIP-Seq_HEART_Mouse1.06475418
127PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.05642241
128NCOR1_26117541_ChIP-Seq_K562_Human1.04980739
129TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.04819680
130JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.03594177
131KLF5_25053715_ChIP-Seq_YYC3_Human1.03442632
132GATA6_25053715_ChIP-Seq_YYC3_Human1.03370613
133PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.01852903
134DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.01416756
135STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.01364774
136SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.00885437
137SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.99875917
138SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.99875917
139* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.99158034
140GATA2_21666600_ChIP-Seq_HMVEC_Human0.96949087
141* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.96935847
142TCF7_22412390_ChIP-Seq_EML_Mouse0.96169800
143TCF3_18692474_ChIP-Seq_MEFs_Mouse0.96046681
144FOXM1_23109430_ChIP-Seq_U2OS_Human0.95342828
145ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94829355
146UBF1/2_26484160_Chip-Seq_HMECs_Human0.94169287
147EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.93790168
148EP300_21415370_ChIP-Seq_HL-1_Mouse0.93491564
149TP63_22573176_ChIP-Seq_HFKS_Human0.93005064
150AHR_22903824_ChIP-Seq_MCF-7_Human0.92966868
151CDX2_19796622_ChIP-Seq_MESCs_Mouse0.92636103
152TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.92310995
153CREB1_26743006_Chip-Seq_LNCaP_Human0.91263260

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier4.62318208
2MP0005410_abnormal_fertilization4.22423276
3MP0010234_abnormal_vibrissa_follicle4.20890243
4MP0000678_abnormal_parathyroid_gland3.91301017
5MP0003941_abnormal_skin_development3.40387766
6MP0000579_abnormal_nail_morphology3.22170644
7MP0005670_abnormal_white_adipose3.17766145
8MP0010368_abnormal_lymphatic_system3.04327194
9MP0003705_abnormal_hypodermis_morpholog2.95045194
10MP0005275_abnormal_skin_tensile2.86501110
11MP0010678_abnormal_skin_adnexa2.74947108
12MP0005501_abnormal_skin_physiology2.74564615
13MP0001879_abnormal_lymphatic_vessel2.73054589
14MP0000383_abnormal_hair_follicle2.72796188
15MP0004272_abnormal_basement_membrane2.64952256
16MP0005167_abnormal_blood-brain_barrier2.62556006
17MP0002098_abnormal_vibrissa_morphology2.52619297
18MP0000647_abnormal_sebaceous_gland2.45328232
19MP0003693_abnormal_embryo_hatching2.34976373
20MP0005623_abnormal_meninges_morphology2.12474105
21MP0002254_reproductive_system_inflammat2.07935809
22MP0000467_abnormal_esophagus_morphology2.03861091
23MP0009053_abnormal_anal_canal1.99739528
24MP0010030_abnormal_orbit_morphology1.99222826
25MP0000537_abnormal_urethra_morphology1.98210229
26MP0004381_abnormal_hair_follicle1.89853581
27MP0001216_abnormal_epidermal_layer1.85606321
28MP0010771_integument_phenotype1.77984773
29MP0004957_abnormal_blastocyst_morpholog1.75769308
30MP0000377_abnormal_hair_follicle1.74970041
31MP0000762_abnormal_tongue_morphology1.69887381
32MP0002060_abnormal_skin_morphology1.61700758
33MP0003698_abnormal_male_reproductive1.59440030
34MP0003453_abnormal_keratinocyte_physiol1.56643851
35MP0003385_abnormal_body_wall1.56124248
36MP0006054_spinal_hemorrhage1.55354238
37MP0000566_synostosis1.48812996
38MP0003077_abnormal_cell_cycle1.48476710
39MP0005666_abnormal_adipose_tissue1.48342470
40MP0004264_abnormal_extraembryonic_tissu1.47412088
41MP0004858_abnormal_nervous_system1.47090963
42MP0004782_abnormal_surfactant_physiolog1.45931616
43MP0002249_abnormal_larynx_morphology1.42659021
44MP0004084_abnormal_cardiac_muscle1.40845559
45MP0005187_abnormal_penis_morphology1.40463186
46MP0002877_abnormal_melanocyte_morpholog1.39742526
47MP0003111_abnormal_nucleus_morphology1.38672505
48MP0000681_abnormal_thyroid_gland1.36681817
49MP0002234_abnormal_pharynx_morphology1.34541781
50MP0001188_hyperpigmentation1.32162461
51MP0004885_abnormal_endolymph1.31946757
52MP0009379_abnormal_foot_pigmentation1.29822036
53MP0006138_congestive_heart_failure1.29781989
54MP0001929_abnormal_gametogenesis1.28381428
55MP0003283_abnormal_digestive_organ1.28334916
56MP0004215_abnormal_myocardial_fiber1.28095436
57MP0008932_abnormal_embryonic_tissue1.27563012
58MP0003566_abnormal_cell_adhesion1.26478251
59MP0003279_aneurysm1.26072016
60MP0001849_ear_inflammation1.25097022
61MP0005248_abnormal_Harderian_gland1.25035334
62MP0001730_embryonic_growth_arrest1.24730112
63MP0002653_abnormal_ependyma_morphology1.23829654
64MP0003136_yellow_coat_color1.23074073
65MP0002092_abnormal_eye_morphology1.22893254
66MP0002282_abnormal_trachea_morphology1.20473138
67MP0002085_abnormal_embryonic_tissue1.18326764
68MP0005375_adipose_tissue_phenotype1.17636148
69MP0005377_hearing/vestibular/ear_phenot1.15370133
70MP0003878_abnormal_ear_physiology1.15370133
71MP0009384_cardiac_valve_regurgitation1.15029277
72MP0000003_abnormal_adipose_tissue1.11552852
73MP0005409_darkened_coat_color1.08915920
74MP0001784_abnormal_fluid_regulation1.08127712
75MP0000350_abnormal_cell_proliferation1.07970824
76MP0001340_abnormal_eyelid_morphology1.07587089
77MP0000049_abnormal_middle_ear1.07302034
78MP0010352_gastrointestinal_tract_polyps1.06380660
79MP0004185_abnormal_adipocyte_glucose1.05871314
80MP0000751_myopathy1.04834206
81MP0000534_abnormal_ureter_morphology1.04728993
82MP0003861_abnormal_nervous_system1.02449632
83MP0005380_embryogenesis_phenotype1.00481501
84MP0001672_abnormal_embryogenesis/_devel1.00481501
85* MP0002161_abnormal_fertility/fecundity0.99207098
86MP0000427_abnormal_hair_cycle0.98174298
87MP0000477_abnormal_intestine_morphology0.97354560
88MP0001286_abnormal_eye_development0.96414212
89MP0002111_abnormal_tail_morphology0.96033435
90MP0001346_abnormal_lacrimal_gland0.95583294
91MP0002127_abnormal_cardiovascular_syste0.94954820
92MP0003755_abnormal_palate_morphology0.94513169
93MP0003119_abnormal_digestive_system0.93687293
94MP0000733_abnormal_muscle_development0.92198765
95MP0005076_abnormal_cell_differentiation0.92066596
96MP0000767_abnormal_smooth_muscle0.91656672
97MP0009250_abnormal_appendicular_skeleto0.91647914
98MP0009780_abnormal_chondrocyte_physiolo0.90440532
99MP0010307_abnormal_tumor_latency0.90403488
100* MP0002925_abnormal_cardiovascular_devel0.90094108
101MP0002163_abnormal_gland_morphology0.89992362
102MP0002009_preneoplasia0.89961450
103MP0001348_abnormal_lacrimal_gland0.89675283
104MP0003828_pulmonary_edema0.89506932
105MP0009931_abnormal_skin_appearance0.88836655
106MP0003315_abnormal_perineum_morphology0.88000653
107MP0010630_abnormal_cardiac_muscle0.87746842
108MP0003935_abnormal_craniofacial_develop0.87035610
109MP0004947_skin_inflammation0.86493189
110MP0000465_gastrointestinal_hemorrhage0.86142567
111MP0009672_abnormal_birth_weight0.85870408
112MP0001191_abnormal_skin_condition0.85713362
113MP0000428_abnormal_craniofacial_morphol0.85437808
114MP0000490_abnormal_crypts_of0.84616597
115MP0003942_abnormal_urinary_system0.84329242
116MP0003984_embryonic_growth_retardation0.82954346
117MP0003115_abnormal_respiratory_system0.82665584
118MP0002114_abnormal_axial_skeleton0.82326858
119MP0002972_abnormal_cardiac_muscle0.82185178
120MP0001958_emphysema0.81820993
121MP0002697_abnormal_eye_size0.80571197
122MP0003300_gastrointestinal_ulcer0.80462182
123MP0003123_paternal_imprinting0.80380964
124MP0002932_abnormal_joint_morphology0.79320726
125MP0002080_prenatal_lethality0.78683644
126MP0000026_abnormal_inner_ear0.78523603
127MP0002084_abnormal_developmental_patter0.78296554
128MP0002088_abnormal_embryonic_growth/wei0.75829843
129MP0005451_abnormal_body_composition0.75367777
130MP0009278_abnormal_bone_marrow0.74222743
131MP0003938_abnormal_ear_development0.74085171
132MP0000778_abnormal_nervous_system0.73563058
133MP0002233_abnormal_nose_morphology0.73416707
134MP0003937_abnormal_limbs/digits/tail_de0.73413313
135MP0000613_abnormal_salivary_gland0.72407761
136MP0001293_anophthalmia0.71618412
137MP0000516_abnormal_urinary_system0.71423170
138MP0005367_renal/urinary_system_phenotyp0.71423170
139MP0002086_abnormal_extraembryonic_tissu0.71245210
140MP0004085_abnormal_heartbeat0.70576933
141MP0000750_abnormal_muscle_regeneration0.70553676
142MP0001544_abnormal_cardiovascular_syste0.69478297
143MP0005385_cardiovascular_system_phenoty0.69478297
144MP0002128_abnormal_blood_circulation0.69339064
145MP0005379_endocrine/exocrine_gland_phen0.69259413
146MP0010094_abnormal_chromosome_stability0.69213256
147MP0000432_abnormal_head_morphology0.68812899
148MP0002116_abnormal_craniofacial_bone0.68564692
149MP0005330_cardiomyopathy0.67883385
150MP0000367_abnormal_coat/_hair0.67612172
151MP0005620_abnormal_muscle_contractility0.67157000

Predicted human phenotypes

RankGene SetZ-score
1Double outlet right ventricle (HP:0001719)4.86068072
2Congenital malformation of the right heart (HP:0011723)4.86068072
3Abnormality of nail color (HP:0100643)4.81590839
4Woolly hair (HP:0002224)4.80630324
5Onycholysis (HP:0001806)4.74847677
6Hypotrichosis (HP:0001006)4.59270230
7Abnormality of the aortic arch (HP:0012303)4.58008587
8Milia (HP:0001056)4.30404164
9Unilateral renal agenesis (HP:0000122)4.18259653
10Fragile nails (HP:0001808)4.06661157
11Septate vagina (HP:0001153)3.93216494
12Abnormality of the distal phalanx of the thumb (HP:0009617)3.83966884
13Right ventricular cardiomyopathy (HP:0011663)3.71374731
14Plantar hyperkeratosis (HP:0007556)3.63707648
15Abnormal ventriculo-arterial connection (HP:0011563)3.62344914
16Transposition of the great arteries (HP:0001669)3.62344914
17Abnormal connection of the cardiac segments (HP:0011545)3.62344914
18Aplasia/Hypoplasia of the sacrum (HP:0008517)3.52827179
19Abnormality of the phalanges of the hallux (HP:0010057)3.49717056
20Truncus arteriosus (HP:0001660)3.40374297
21Renal dysplasia (HP:0000110)3.36966017
22Hyperthyroidism (HP:0000836)3.34922733
23Abnormality of the parathyroid morphology (HP:0011766)3.33516527
24Megalencephaly (HP:0001355)3.29226597
25Short 4th metacarpal (HP:0010044)3.28446355
26Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.28446355
27Palmoplantar hyperkeratosis (HP:0000972)3.27142352
28Increased IgE level (HP:0003212)3.12515892
29Palmar hyperkeratosis (HP:0010765)3.07045915
30Hypoplastic left heart (HP:0004383)3.03698153
31Ventricular tachycardia (HP:0004756)2.95788293
32Nail dystrophy (HP:0008404)2.90922219
33Aplasia cutis congenita (HP:0001057)2.90070269
34Pili torti (HP:0003777)2.82291958
35Abnormality of chromosome segregation (HP:0002916)2.78178849
36Abnormality of the 4th metacarpal (HP:0010012)2.73087875
37Periauricular skin pits (HP:0100277)2.68803743
38Preauricular pit (HP:0004467)2.68803743
39Sudden death (HP:0001699)2.64319493
40Aplasia involving bones of the upper limbs (HP:0009823)2.62850494
41Aplasia of the phalanges of the hand (HP:0009802)2.62850494
42Aplasia involving bones of the extremities (HP:0009825)2.62850494
43Hyporeflexia of lower limbs (HP:0002600)2.57533650
44Bronchomalacia (HP:0002780)2.54414611
45Broad distal phalanx of finger (HP:0009836)2.54142972
46Skin pits (HP:0100276)2.52757428
47Bowel incontinence (HP:0002607)2.52401730
48Pseudobulbar signs (HP:0002200)2.50336622
49Conjunctival hamartoma (HP:0100780)2.43640903
50Partial duplication of thumb phalanx (HP:0009944)2.40022966
51Abnormal large intestine physiology (HP:0012700)2.39875896
52Mesangial abnormality (HP:0001966)2.39686115
53Hypoplastic heart (HP:0001961)2.38851323
54Down-sloping shoulders (HP:0200021)2.38178824
55Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.36062121
56Blepharitis (HP:0000498)2.34427187
57Round ear (HP:0100830)2.32171804
58Thick nail (HP:0001805)2.31282951
59Hypoparathyroidism (HP:0000829)2.30745917
60Partial duplication of the phalanx of hand (HP:0009999)2.27935547
61Flattened epiphyses (HP:0003071)2.27796420
62Alopecia of scalp (HP:0002293)2.27471848
63Ridged nail (HP:0001807)2.27031213
64Aortic aneurysm (HP:0004942)2.25995513
65Adactyly (HP:0009776)2.25573859
66Atrophic scars (HP:0001075)2.25212378
67Ulnar bowing (HP:0003031)2.22435598
68Advanced eruption of teeth (HP:0006288)2.22370761
69Bifid scrotum (HP:0000048)2.21485766
70Resting tremor (HP:0002322)2.20732610
71Intestinal fistula (HP:0100819)2.20091695
72Curly hair (HP:0002212)2.20087567
73Ventricular fibrillation (HP:0001663)2.19783053
74Severe visual impairment (HP:0001141)2.19741736
75Shallow orbits (HP:0000586)2.17283509
76Abnormal number of incisors (HP:0011064)2.15171122
77Atelectasis (HP:0100750)2.14329503
78Breast hypoplasia (HP:0003187)2.14302708
79Follicular hyperkeratosis (HP:0007502)2.13858322
80Seborrheic dermatitis (HP:0001051)2.13185112
81Broad face (HP:0000283)2.12868832
82Hyperacusis (HP:0010780)2.12782219
83Bell-shaped thorax (HP:0001591)2.12741371
84Skull defect (HP:0001362)2.11439531
85Vaginal fistula (HP:0004320)2.11165076
86Rectal fistula (HP:0100590)2.10024849
87Rectovaginal fistula (HP:0000143)2.10024849
88Difficulty running (HP:0009046)2.07728056
89Polycythemia (HP:0001901)2.07590282
90Esophageal atresia (HP:0002032)2.07445714
91Hyperkalemia (HP:0002153)2.06356558
92Hyperactive renin-angiotensin system (HP:0000841)2.06349850
93Germ cell neoplasia (HP:0100728)2.05297186
94Absent eyelashes (HP:0000561)2.04950118
95Ankyloglossia (HP:0010296)2.04515537
96High anterior hairline (HP:0009890)2.02879620
97Renal duplication (HP:0000075)2.01595894
98Abnormally folded helix (HP:0008544)2.01516244
99Aplasia/Hypoplasia of the earlobes (HP:0009906)2.01406027
100Abnormality of the distal phalanges of the toes (HP:0010182)1.99769910
101Vertebral clefting (HP:0008428)1.99477987
102Hematochezia (HP:0002573)1.99220241
103Natal tooth (HP:0000695)1.98561135
104Impulsivity (HP:0100710)1.94164561
105Porencephaly (HP:0002132)1.92957197
106Hyponatremia (HP:0002902)1.92880950
107Back pain (HP:0003418)1.92642688
108Abnormal blistering of the skin (HP:0008066)1.92416498
109Patellar dislocation (HP:0002999)1.91120244
110Lip pit (HP:0100267)1.90311067
111Abnormality of the fetal cardiovascular system (HP:0010948)1.90275931
112Abnormal umbilical cord blood vessels (HP:0011403)1.90275931
113Single umbilical artery (HP:0001195)1.90275931
114Abnormality of the parietal bone (HP:0002696)1.90091325
115Absent hair (HP:0002298)1.89395606
116Flat acetabular roof (HP:0003180)1.88497783
117Hypoplastic toenails (HP:0001800)1.87831346
118Underdeveloped nasal alae (HP:0000430)1.87823189
119Abnormality of the axillary hair (HP:0100134)1.86253552
120Abnormality of secondary sexual hair (HP:0009888)1.86253552
121Increased connective tissue (HP:0009025)1.86083848
122Acanthosis nigricans (HP:0000956)1.85545361
123Hemiplegia (HP:0002301)1.85522599
124Hamartoma of the eye (HP:0010568)1.84284122
125Abdominal distention (HP:0003270)1.83814615
126Palmoplantar keratoderma (HP:0000982)1.83498604
127Slow-growing hair (HP:0002217)1.83283922
128Abnormality of hair growth rate (HP:0011363)1.83283922
129Short hallux (HP:0010109)1.82573748
130Pterygium (HP:0001059)1.82512161
131Abnormality of the diencephalon (HP:0010662)1.82389520
132Short palpebral fissure (HP:0012745)1.81927498
133Overfolded helix (HP:0000396)1.81898547
134Fibrous tissue neoplasm (HP:0012316)1.80996472
135Fibroma (HP:0010614)1.80935350
136Vesicoureteral reflux (HP:0000076)1.80877656
137Absent eyebrow (HP:0002223)1.80547179
138Rectal prolapse (HP:0002035)1.80347875
139Turricephaly (HP:0000262)1.80102641
140Anonychia (HP:0001798)1.80101039
141Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.79776113
142Vascular tortuosity (HP:0004948)1.79297308
143Short phalanx of the thumb (HP:0009660)1.78622507
144Annular pancreas (HP:0001734)1.78470244
145Birth length less than 3rd percentile (HP:0003561)1.77876034
146Overgrowth (HP:0001548)1.77476439
147Neoplasm of the heart (HP:0100544)1.76981256
148Maternal diabetes (HP:0009800)1.76864882
149Posterior embryotoxon (HP:0000627)1.76856368
150Hamartoma (HP:0010566)1.75468274
151Supernumerary ribs (HP:0005815)1.75338631
152Atresia of the external auditory canal (HP:0000413)1.74726083
153Anal stenosis (HP:0002025)1.74574461
154Congenital, generalized hypertrichosis (HP:0004540)1.74488207
155Laryngomalacia (HP:0001601)1.73898091
156Duplication of thumb phalanx (HP:0009942)1.73246481
157Obsessive-compulsive behavior (HP:0000722)1.72762327
158Hypohidrosis (HP:0000966)1.72132331
159Lymphangioma (HP:0100764)1.71031655
160Sex reversal (HP:0012245)1.70931530
161Abnormal sex determination (HP:0012244)1.70931530
162Abnormality of the gastric mucosa (HP:0004295)1.70394803
163Abnormality of the nasal mucosa (HP:0000433)1.69705705
164Abnormality of oral frenula (HP:0000190)1.69605062
165Supraventricular arrhythmia (HP:0005115)1.67834301
166Obstructive sleep apnea (HP:0002870)1.67765521
167Male infertility (HP:0003251)1.67693179
168Bladder diverticulum (HP:0000015)1.66945247
169Coronal craniosynostosis (HP:0004440)1.65885339
170Asymmetric septal hypertrophy (HP:0001670)1.65702765
171Atrial fibrillation (HP:0005110)1.65511017
172Hyperparathyroidism (HP:0000843)1.64600590
173Asymmetry of the thorax (HP:0001555)1.64189796
174Absent toe (HP:0010760)1.64068857
175Mitral valve prolapse (HP:0001634)1.63692859
176Glossoptosis (HP:0000162)1.63153073
177Renal agenesis (HP:0000104)1.63071197
178Primary atrial arrhythmia (HP:0001692)1.62934669
179Abnormal vertebral ossification (HP:0100569)1.61921822
180Midline defect of the nose (HP:0004122)1.61500773
181Trigonocephaly (HP:0000243)1.60195847
182Progressive sensorineural hearing impairment (HP:0000408)1.59772215
183Thin ribs (HP:0000883)1.58975307
184Abnormality of chloride homeostasis (HP:0011422)1.58431767
185Hypoplastic ischia (HP:0003175)1.56087197
186Bicornuate uterus (HP:0000813)1.56025800

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE14.89918360
2EPHB24.27538948
3TRIB34.16362856
4CDK124.10799886
5SMG13.63045375
6TESK13.47232739
7MAPK153.09645518
8PLK42.92914857
9KDR2.75020600
10EEF2K2.44691118
11BRD42.26645431
12PKN22.20090169
13NTRK22.15880121
14PNCK2.13891380
15LRRK22.13362207
16PTK62.08185747
17FER2.06203129
18ICK2.06139598
19LATS12.03228498
20MST1R2.00121766
21STK241.91252047
22IRAK31.91018045
23MAPKAPK31.89413472
24CAMK1D1.83707439
25DMPK1.82538299
26MAP3K101.82406511
27CDK71.77468576
28EPHA41.76373375
29RIPK11.75161861
30LMTK21.72570210
31TGFBR11.64877166
32TGFBR21.63346700
33LATS21.61322240
34RPS6KB21.56276381
35VRK21.54852962
36ILK1.48171717
37PDGFRA1.42972536
38TTN1.38628538
39MST41.37660631
40TAF11.36510745
41MTOR1.30540166
42PRPF4B1.30412617
43PHKG21.27806195
44PHKG11.27806195
45CDC71.21752982
46CDK61.20795900
47TYRO31.19847976
48NME21.15002598
49EPHB11.12369201
50FGFR21.11998807
51PDPK11.11716631
52BRAF1.08705356
53STK381.08243699
54PRKD31.07207397
55MAP3K21.06307872
56PRKD11.05748841
57FGFR10.99292378
58MAP3K90.98808713
59IRAK20.96159183
60ERBB20.95738587
61KSR10.95211996
62TAOK10.95022652
63EPHA30.92664445
64KSR20.90890144
65MAP3K110.90749497
66MAP3K70.89468821
67PRKG20.89171553
68PTK2B0.86121500
69STK100.84938191
70PAK40.84093863
71FGFR30.83940410
72DYRK30.81474235
73CHEK20.79442339
74RPS6KA20.79193830
75VRK10.75827406
76PTK20.75212655
77AURKA0.74321554
78MAPK120.74214202
79MAP3K30.73958360
80PAK30.73214394
81SIK10.72239236
82ROCK10.71867865
83BMX0.71475267
84MAP2K20.71223840
85RPS6KL10.70191936
86RPS6KC10.70191936
87PAK20.70076294
88ALK0.69388887
89CHEK10.69333786
90RET0.66906340
91CDK20.66168808
92PRKD20.64583945
93CDK90.63303062
94GRK60.61402928
95MAPK110.60405666
96STK110.60385292
97CLK10.58027042
98RPS6KA60.57724645
99DYRK1B0.57674888
100FGR0.57487813
101GRK10.57364930
102HIPK20.57015860
103ARAF0.56837819
104STK40.55778413
105AKT20.55666455
106RPS6KA10.55356025
107PDK10.54983676
108EPHA20.54039544
109CDK10.52539328
110STK390.52312984
111TESK20.51549924
112DDR20.50987333
113FGFR40.50887815
114MAPKAPK50.48926695
115MET0.48469653
116GSK3B0.48117223
117INSRR0.47004303
118MARK10.46833010
119CDK30.45609251
120MARK20.45178900
121NLK0.44795807
122SGK30.44784185
123CAMK1G0.44742071
124UHMK10.43050045
125TLK10.42515332
126WEE10.41823779
127RPS6KA40.41413907
128CDK80.41356500
129TTK0.40540998
130ADRBK10.40487995
131MKNK20.40378146
132SRC0.40116408
133CDK40.39688157
134CDK140.39546360
135BRSK10.38244443
136PAK60.38237049
137NEK60.37728989
138MAPK140.37717693
139CAMK40.36174235
140MAP2K10.36017237
141ERBB30.36011972
142ATR0.35915670
143WNK10.35913101
144TAOK20.35654967
145PDGFRB0.35521383
146MAPK80.35065264
147STK38L0.34813063
148TSSK60.33729263
149PRKCH0.33570455
150AURKB0.33203679
151CSNK1D0.31982294
152MAPK90.31256742
153CDK50.31204689
154MINK10.31076566
155ROCK20.29944569
156AKT10.28717891
157MAP3K80.28302867
158BUB10.27307598
159MAP3K10.26901841

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041223.59890464
2Nitrogen metabolism_Homo sapiens_hsa009103.58167476
3Basal cell carcinoma_Homo sapiens_hsa052172.66202090
4Dorso-ventral axis formation_Homo sapiens_hsa043202.42017432
5Notch signaling pathway_Homo sapiens_hsa043302.21529915
6Cyanoamino acid metabolism_Homo sapiens_hsa004602.10752526
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.09885308
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.96527526
9Axon guidance_Homo sapiens_hsa043601.92661399
10Hippo signaling pathway_Homo sapiens_hsa043901.91389889
11DNA replication_Homo sapiens_hsa030301.89459806
12Arginine and proline metabolism_Homo sapiens_hsa003301.82114783
13Melanogenesis_Homo sapiens_hsa049161.78919804
14Adherens junction_Homo sapiens_hsa045201.78087029
15Hedgehog signaling pathway_Homo sapiens_hsa043401.74568797
16Arginine biosynthesis_Homo sapiens_hsa002201.61339569
17Tight junction_Homo sapiens_hsa045301.61211671
18Spliceosome_Homo sapiens_hsa030401.56615241
19ECM-receptor interaction_Homo sapiens_hsa045121.55209479
20Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.51536525
21Wnt signaling pathway_Homo sapiens_hsa043101.47322656
22Proteoglycans in cancer_Homo sapiens_hsa052051.46345349
23Base excision repair_Homo sapiens_hsa034101.45762273
24Renin secretion_Homo sapiens_hsa049241.44544081
25VEGF signaling pathway_Homo sapiens_hsa043701.42893704
26Rap1 signaling pathway_Homo sapiens_hsa040151.41562607
27Focal adhesion_Homo sapiens_hsa045101.41523348
28Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.40634894
29Gastric acid secretion_Homo sapiens_hsa049711.40103608
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.37459679
31Dilated cardiomyopathy_Homo sapiens_hsa054141.36927281
32Endometrial cancer_Homo sapiens_hsa052131.36626716
33MicroRNAs in cancer_Homo sapiens_hsa052061.36111484
34Colorectal cancer_Homo sapiens_hsa052101.33871150
35Estrogen signaling pathway_Homo sapiens_hsa049151.32955968
36Cell cycle_Homo sapiens_hsa041101.32633775
37Prion diseases_Homo sapiens_hsa050201.32420620
38mRNA surveillance pathway_Homo sapiens_hsa030151.32119123
39Glioma_Homo sapiens_hsa052141.31411852
40Biosynthesis of amino acids_Homo sapiens_hsa012301.30811062
41Small cell lung cancer_Homo sapiens_hsa052221.30438182
42Fatty acid biosynthesis_Homo sapiens_hsa000611.29898014
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.28908869
44Gap junction_Homo sapiens_hsa045401.27386270
45Renal cell carcinoma_Homo sapiens_hsa052111.27351891
46Leukocyte transendothelial migration_Homo sapiens_hsa046701.26160054
47RNA transport_Homo sapiens_hsa030131.25043214
48Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.24973335
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.21780979
50Thyroid hormone signaling pathway_Homo sapiens_hsa049191.18354397
51Salivary secretion_Homo sapiens_hsa049701.17796615
52Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.16459402
53Bladder cancer_Homo sapiens_hsa052191.15109161
54Phenylalanine metabolism_Homo sapiens_hsa003601.14450096
55Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.10261380
56Maturity onset diabetes of the young_Homo sapiens_hsa049501.10259042
57Pathways in cancer_Homo sapiens_hsa052001.09499903
58Chronic myeloid leukemia_Homo sapiens_hsa052201.08524319
59TGF-beta signaling pathway_Homo sapiens_hsa043501.08425065
60Fat digestion and absorption_Homo sapiens_hsa049751.07573455
61Thyroid cancer_Homo sapiens_hsa052161.06608350
62cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05103220
632-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.04306555
64Alcoholism_Homo sapiens_hsa050341.03114994
65Ribosome_Homo sapiens_hsa030101.02844132
66Oxytocin signaling pathway_Homo sapiens_hsa049211.02834545
67Platelet activation_Homo sapiens_hsa046111.01581202
68Circadian entrainment_Homo sapiens_hsa047131.01132994
69Lysine degradation_Homo sapiens_hsa003101.00693886
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.99726803
71GnRH signaling pathway_Homo sapiens_hsa049120.99120975
72Longevity regulating pathway - mammal_Homo sapiens_hsa042110.98592039
73Ras signaling pathway_Homo sapiens_hsa040140.98383377
74Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.97610180
75Phospholipase D signaling pathway_Homo sapiens_hsa040720.95673600
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.94654097
77Renin-angiotensin system_Homo sapiens_hsa046140.92137797
78Long-term depression_Homo sapiens_hsa047300.91965135
79Non-small cell lung cancer_Homo sapiens_hsa052230.90568396
80Viral myocarditis_Homo sapiens_hsa054160.90160408
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.90055306
82AMPK signaling pathway_Homo sapiens_hsa041520.89718665
83Olfactory transduction_Homo sapiens_hsa047400.89407415
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.89088182
85cAMP signaling pathway_Homo sapiens_hsa040240.87481904
86Long-term potentiation_Homo sapiens_hsa047200.87053561
87Insulin signaling pathway_Homo sapiens_hsa049100.85266771
88Viral carcinogenesis_Homo sapiens_hsa052030.85045407
89Regulation of actin cytoskeleton_Homo sapiens_hsa048100.84874006
90HTLV-I infection_Homo sapiens_hsa051660.84037493
91Aldosterone synthesis and secretion_Homo sapiens_hsa049250.83331844
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.82682557
93Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.82017723
94Fructose and mannose metabolism_Homo sapiens_hsa000510.81749290
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.80414456
96Cholinergic synapse_Homo sapiens_hsa047250.80246288
97Vitamin B6 metabolism_Homo sapiens_hsa007500.79816934
98Glutamatergic synapse_Homo sapiens_hsa047240.79745914
99Pancreatic cancer_Homo sapiens_hsa052120.77922584
100Melanoma_Homo sapiens_hsa052180.75834482
101Amoebiasis_Homo sapiens_hsa051460.75291516
102Inositol phosphate metabolism_Homo sapiens_hsa005620.75211689
103Cocaine addiction_Homo sapiens_hsa050300.74617043
104Systemic lupus erythematosus_Homo sapiens_hsa053220.73391064
105Prostate cancer_Homo sapiens_hsa052150.72328841
106Pancreatic secretion_Homo sapiens_hsa049720.71453053
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71284710
108ErbB signaling pathway_Homo sapiens_hsa040120.70825890
109Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69310377
110Acute myeloid leukemia_Homo sapiens_hsa052210.68984985
111Choline metabolism in cancer_Homo sapiens_hsa052310.68491613
112Calcium signaling pathway_Homo sapiens_hsa040200.68217531
113Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.66860322
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.65844588
115Protein digestion and absorption_Homo sapiens_hsa049740.65741756
116Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65019663
117Neurotrophin signaling pathway_Homo sapiens_hsa047220.64691644
118Pyrimidine metabolism_Homo sapiens_hsa002400.63994042
119PI3K-Akt signaling pathway_Homo sapiens_hsa041510.62795833
120GABAergic synapse_Homo sapiens_hsa047270.62028959
121Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.61975275
122mTOR signaling pathway_Homo sapiens_hsa041500.61921758
123HIF-1 signaling pathway_Homo sapiens_hsa040660.61677143
124Oocyte meiosis_Homo sapiens_hsa041140.61181952
125Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.61028001
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.60372346
127Insulin resistance_Homo sapiens_hsa049310.59313133
128Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59122686
129PPAR signaling pathway_Homo sapiens_hsa033200.58892361
130MAPK signaling pathway_Homo sapiens_hsa040100.58610955
131Dopaminergic synapse_Homo sapiens_hsa047280.58418415
132Bile secretion_Homo sapiens_hsa049760.58237749
133Endocytosis_Homo sapiens_hsa041440.57741993
134Cardiac muscle contraction_Homo sapiens_hsa042600.57482501
135Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55956116
136Sulfur metabolism_Homo sapiens_hsa009200.55538159
137Morphine addiction_Homo sapiens_hsa050320.54150429
138Insulin secretion_Homo sapiens_hsa049110.53410052
139Toxoplasmosis_Homo sapiens_hsa051450.53316190
140Fatty acid metabolism_Homo sapiens_hsa012120.50885054
141Galactose metabolism_Homo sapiens_hsa000520.49370713
142Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48676031
143Type II diabetes mellitus_Homo sapiens_hsa049300.46944837
144Carbon metabolism_Homo sapiens_hsa012000.45975529
145Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45168653
146Fatty acid degradation_Homo sapiens_hsa000710.44628868
147Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.39492712
148FoxO signaling pathway_Homo sapiens_hsa040680.38745460
149Mismatch repair_Homo sapiens_hsa034300.36802435
150Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35466463
151Purine metabolism_Homo sapiens_hsa002300.34975122
152Carbohydrate digestion and absorption_Homo sapiens_hsa049730.34594616

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