NRAP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)9.26971910
2muscle filament sliding (GO:0030049)9.17038240
3actin-myosin filament sliding (GO:0033275)9.17038240
4regulation of skeletal muscle contraction (GO:0014819)7.91186741
5myofibril assembly (GO:0030239)7.77747874
6cardiac myofibril assembly (GO:0055003)7.76134639
7negative regulation of potassium ion transmembrane transporter activity (GO:1901017)7.64235867
8actin-mediated cell contraction (GO:0070252)7.55936294
9plasma membrane repair (GO:0001778)7.36312265
10positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)7.28435387
11sarcoplasmic reticulum calcium ion transport (GO:0070296)6.93074135
12negative regulation of potassium ion transmembrane transport (GO:1901380)6.73575146
13regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.62523111
14cardiac muscle contraction (GO:0060048)6.36627933
15striated muscle contraction (GO:0006941)6.04427243
16regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO5.96025801
17skeletal muscle contraction (GO:0003009)5.94494253
18actomyosin structure organization (GO:0031032)5.91516406
19regulation of relaxation of muscle (GO:1901077)5.89750619
20cardiac muscle cell development (GO:0055013)5.86506189
21tricarboxylic acid cycle (GO:0006099)5.80372061
22regulation of actin filament-based movement (GO:1903115)5.70116547
23actin filament-based movement (GO:0030048)5.69114300
24carnitine shuttle (GO:0006853)5.59887763
25regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.54470283
26cardiac cell development (GO:0055006)5.50364301
27regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.41113048
28regulation of cell communication by electrical coupling (GO:0010649)5.39069792
29regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)5.38089799
30response to stimulus involved in regulation of muscle adaptation (GO:0014874)5.28048326
31regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)5.25078870
32adult heart development (GO:0007512)5.13274972
33ventricular cardiac muscle cell action potential (GO:0086005)5.11343651
34cardiac muscle tissue morphogenesis (GO:0055008)5.09996808
35cardiac muscle hypertrophy (GO:0003300)5.03179054
36regulation of acyl-CoA biosynthetic process (GO:0050812)4.92164375
37striated muscle hypertrophy (GO:0014897)4.87616279
38skeletal muscle adaptation (GO:0043501)4.83984251
39regulation of striated muscle contraction (GO:0006942)4.81350035
40fatty acid transmembrane transport (GO:1902001)4.79611384
41bundle of His cell to Purkinje myocyte communication (GO:0086069)4.77642974
42creatine metabolic process (GO:0006600)4.75667379
43muscle tissue morphogenesis (GO:0060415)4.74270302
44regulation of sarcomere organization (GO:0060297)4.67308845
45heart contraction (GO:0060047)4.60047979
46heart process (GO:0003015)4.60047979
47ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.55640847
48regulation of cofactor metabolic process (GO:0051193)4.46095392
49regulation of coenzyme metabolic process (GO:0051196)4.46095392
50skeletal muscle fiber development (GO:0048741)4.43651950
51regulation of membrane repolarization (GO:0060306)4.41036166
52heart trabecula formation (GO:0060347)4.35910824
53muscle contraction (GO:0006936)4.34892237
54muscle hypertrophy (GO:0014896)4.30528980
55response to inactivity (GO:0014854)4.26448213
56myotube cell development (GO:0014904)4.17384392
57carnitine transmembrane transport (GO:1902603)4.14526317
58muscle atrophy (GO:0014889)4.13756336
59positive regulation of calcium ion transmembrane transporter activity (GO:1901021)4.06316364
60cell communication involved in cardiac conduction (GO:0086065)4.00190392
61muscle system process (GO:0003012)3.99736058
62striated muscle adaptation (GO:0014888)3.99029048
63regulation of the force of heart contraction (GO:0002026)3.93070697
64striated muscle cell development (GO:0055002)3.92176028
65regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.91416231
66cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.91077089
67skeletal muscle tissue development (GO:0007519)3.84860502
68negative regulation of protein localization to cell surface (GO:2000009)3.79889118
69carnitine transport (GO:0015879)3.77632507
70amino-acid betaine transport (GO:0015838)3.77632507
71striated muscle atrophy (GO:0014891)3.76941150
72glycogen biosynthetic process (GO:0005978)3.76341013
73glucan biosynthetic process (GO:0009250)3.76341013
742-oxoglutarate metabolic process (GO:0006103)3.72854394
75positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.70357974
76cardiac muscle cell action potential (GO:0086001)3.68523464
77NADH metabolic process (GO:0006734)3.68068507
78negative regulation of potassium ion transport (GO:0043267)3.67283508
79cardiac muscle cell action potential involved in contraction (GO:0086002)3.67253812
80response to muscle activity (GO:0014850)3.65265217
81glycogen catabolic process (GO:0005980)3.64140279
82regulation of sulfur metabolic process (GO:0042762)3.64077460
83cellular polysaccharide catabolic process (GO:0044247)3.63541604
84cardiac muscle adaptation (GO:0014887)3.63446005
85cardiac muscle hypertrophy in response to stress (GO:0014898)3.63446005
86muscle hypertrophy in response to stress (GO:0003299)3.63446005
87regulation of cardiac muscle contraction (GO:0055117)3.61983463
88regulation of calcium ion transmembrane transport (GO:1903169)3.61263858
89regulation of calcium ion transmembrane transporter activity (GO:1901019)3.61263858
90muscle fiber development (GO:0048747)3.60251868
91regulation of ATPase activity (GO:0043462)3.60031108
92regulation of ATP catabolic process (GO:1903289)3.60031108
93negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.57051375
94muscle cell cellular homeostasis (GO:0046716)3.55021250
95response to epinephrine (GO:0071871)3.54673685
96positive regulation of cation channel activity (GO:2001259)3.54495078
97regulation of heart rate (GO:0002027)3.54166078
98regulation of muscle system process (GO:0090257)3.53777438
99negative regulation of calcium ion transmembrane transport (GO:1903170)3.52307587
100negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.52307587
101regulation of cardiac muscle cell contraction (GO:0086004)3.52223817
102pyrimidine ribonucleoside catabolic process (GO:0046133)3.51633722
103response to caffeine (GO:0031000)3.51629511
104regulation of sequestering of triglyceride (GO:0010889)3.50668725
105mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.50237012
106membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.46424254
107skeletal muscle tissue regeneration (GO:0043403)3.45869702
108mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.43398932
109glucan catabolic process (GO:0009251)3.39547238
110muscle cell development (GO:0055001)3.36052496
111muscle adaptation (GO:0043500)3.33796570
112cell communication by electrical coupling (GO:0010644)3.32783584
113cellular response to epinephrine stimulus (GO:0071872)3.32644722
114regulation of muscle contraction (GO:0006937)3.32593597
115respiratory electron transport chain (GO:0022904)3.30630665
116cytidine catabolic process (GO:0006216)3.29746751
117cytidine deamination (GO:0009972)3.29746751
118cytidine metabolic process (GO:0046087)3.29746751
119oxidative phosphorylation (GO:0006119)3.29719583
120polysaccharide catabolic process (GO:0000272)3.26389845
121detection of calcium ion (GO:0005513)3.20877537

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.04634988
2* EP300_21415370_ChIP-Seq_HL-1_Mouse4.04938751
3* TBX20_22080862_ChIP-Seq_HEART_Mouse3.91502133
4* TBX20_22328084_ChIP-Seq_HEART_Mouse3.91502133
5ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.87224937
6TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.77595438
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.68608893
8BP1_19119308_ChIP-ChIP_Hs578T_Human3.66353712
9ESR1_20079471_ChIP-ChIP_T-47D_Human3.35277936
10ZNF263_19887448_ChIP-Seq_K562_Human3.31787356
11RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.02066813
12* MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.80961151
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.76902470
14CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.43261375
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.16899199
16CDX2_19796622_ChIP-Seq_MESCs_Mouse2.15909140
17GATA4_21415370_ChIP-Seq_HL-1_Mouse2.13892175
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.12524275
19PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.06587449
20EZH2_22144423_ChIP-Seq_EOC_Human2.01798953
21ESR2_21235772_ChIP-Seq_MCF-7_Human1.95541754
22NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.93569078
23EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.83416288
24ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.79634251
25ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.70826146
26TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.70593350
27NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.62800592
28CLOCK_20551151_ChIP-Seq_293T_Human1.61487846
29PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.58982289
30CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.53333321
31CTCF_27219007_Chip-Seq_Bcells_Human1.44725206
32NFIB_24661679_ChIP-Seq_LUNG_Mouse1.42651886
33KDM2B_26808549_Chip-Seq_SUP-B15_Human1.41483882
34BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.39285200
35DROSHA_22980978_ChIP-Seq_HELA_Human1.33071415
36EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.31507084
37BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.31262619
38PPARA_22158963_ChIP-Seq_LIVER_Mouse1.31056530
39TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30940275
40KDM2B_26808549_Chip-Seq_DND41_Human1.30596551
41TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.27821538
42PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.22404731
43PPAR_26484153_Chip-Seq_NCI-H1993_Human1.21574622
44TP63_22573176_ChIP-Seq_HFKS_Human1.21416878
45SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21098582
46ESR1_21235772_ChIP-Seq_MCF-7_Human1.20471395
47RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.20062554
48NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.19466413
49IGF1R_20145208_ChIP-Seq_DFB_Human1.17216575
50LXR_22292898_ChIP-Seq_THP-1_Human1.16774829
51VDR_22108803_ChIP-Seq_LS180_Human1.16311657
52GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.15672532
53FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.14718688
54* LXR_22158963_ChIP-Seq_LIVER_Mouse1.14232075
55NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.12667539
56GBX2_23144817_ChIP-Seq_PC3_Human1.12395639
57SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10433521
58HTT_18923047_ChIP-ChIP_STHdh_Human1.09522169
59ATF3_27146783_Chip-Seq_COLON_Human1.09355236
60* RACK7_27058665_Chip-Seq_MCF-7_Human1.08462034
61GATA2_21666600_ChIP-Seq_HMVEC_Human1.06083492
62ELK3_25401928_ChIP-Seq_HUVEC_Human1.05959391
63SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.05393755
64GATA1_19941826_ChIP-Seq_K562_Human1.05176659
65* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.03989506
66RUNX1_27514584_Chip-Seq_MCF-7_Human1.03735671
67KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.03153689
68SMC3_22415368_ChIP-Seq_MEFs_Mouse1.02812668
69PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02385361
70CTCF_21964334_ChIP-Seq_BJAB-B_Human1.02215730
71EZH2_27294783_Chip-Seq_NPCs_Mouse1.02194081
72PCGF2_27294783_Chip-Seq_ESCs_Mouse1.00453615
73OCT4_20526341_ChIP-Seq_ESCs_Human1.00029931
74SOX9_24532713_ChIP-Seq_HFSC_Mouse0.99491032
75FOXH1_21741376_ChIP-Seq_ESCs_Human0.99017885
76SPI1_20517297_ChIP-Seq_HL60_Human0.98334063
77RARB_27405468_Chip-Seq_BRAIN_Mouse0.97583072
78* P68_20966046_ChIP-Seq_HELA_Human0.97308194
79UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.96751299
80RXR_22158963_ChIP-Seq_LIVER_Mouse0.95491941
81ZNF274_21170338_ChIP-Seq_K562_Hela0.94599527
82EZH2_27294783_Chip-Seq_ESCs_Mouse0.94367741
83CTCF_21964334_Chip-Seq_Bcells_Human0.94136933
84P63_26484246_Chip-Seq_KERATINOCYTES_Human0.94088139
85ZFP281_18757296_ChIP-ChIP_E14_Mouse0.93964933
86* SOX2_21211035_ChIP-Seq_LN229_Gbm0.93668978
87GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.92540970
88SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.92518404
89DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92377761
90STAT3_1855785_ChIP-Seq_MESCs_Mouse0.91397355
91CJUN_26792858_Chip-Seq_BT549_Human0.91281921
92EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.90333881
93CRX_20693478_ChIP-Seq_RETINA_Mouse0.88193395
94NR3C1_23031785_ChIP-Seq_PC12_Mouse0.88023926
95GATA2_19941826_ChIP-Seq_K562_Human0.87602384
96SMC1_22415368_ChIP-Seq_MEFs_Mouse0.87262984
97MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.87164908
98NRF2_20460467_ChIP-Seq_MEFs_Mouse0.86861755
99NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.86861755
100ISL1_27105846_Chip-Seq_CPCs_Mouse0.86493423
101LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.86347240
102CTNNB1_20460455_ChIP-Seq_HCT116_Human0.86346848
103STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.86272595
104ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.86025371
105YY1_22570637_ChIP-Seq_MALME-3M_Human0.85766488
106HIF1A_21447827_ChIP-Seq_MCF-7_Human0.85408582
107STAT6_21828071_ChIP-Seq_BEAS2B_Human0.84934345
108PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.84674779
109CREB1_26743006_Chip-Seq_LNCaP_Human0.84570647
110* FOXA2_19822575_ChIP-Seq_HepG2_Human0.84132580
111* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.83921345
112OCT4_21477851_ChIP-Seq_ESCs_Mouse0.83892359
113GATA1_22025678_ChIP-Seq_K562_Human0.83489711
114TRIM28_21343339_ChIP-Seq_HEK293_Human0.82394954
115AUTS2_25519132_ChIP-Seq_293T-REX_Human0.82118490
116BCL6_27268052_Chip-Seq_Bcells_Human0.82050286
117CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.82025743
118E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.82006283
119SA1_27219007_Chip-Seq_Bcells_Human0.81663010
120SMAD3_21741376_ChIP-Seq_HESCs_Human0.80727808
121TP53_23651856_ChIP-Seq_MEFs_Mouse0.80118751
122KDM2B_26808549_Chip-Seq_K562_Human0.80044751
123* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.79323186
124FLI1_27457419_Chip-Seq_LIVER_Mouse0.78477367
125CBX2_27304074_Chip-Seq_ESCs_Mouse0.78420730
126NFE2_27457419_Chip-Seq_LIVER_Mouse0.78222842
127* GATA1_19941827_ChIP-Seq_MEL_Mouse0.78196624
128ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.78021307
129GF1_26923725_Chip-Seq_HPCs_Mouse0.77973768
130TDRD3_21172665_ChIP-Seq_MCF-7_Human0.77236135
131MYC_27129775_Chip-Seq_CORNEA_Mouse0.77207072
132* CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.77111340
133BCOR_27268052_Chip-Seq_Bcells_Human0.76991262
134AR_21572438_ChIP-Seq_LNCaP_Human0.76487987
135SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.76100516
136PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.74784345
137PHF8_20622853_ChIP-Seq_HELA_Human0.74223360
138* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.73764954
139WT1_25993318_ChIP-Seq_PODOCYTE_Human0.73596917
140SMAD4_21741376_ChIP-Seq_HESCs_Human0.72941344
141HNFA_21074721_ChIP-Seq_CACO-2_Human0.72145030
142SMAD4_21799915_ChIP-Seq_A2780_Human0.72130381
143NFYB_21822215_ChIP-Seq_K562_Human0.71326837
144NR3C1_21868756_ChIP-Seq_MCF10A_Human0.70986124
145GATA6_21074721_ChIP-Seq_CACO-2_Human0.70402466
146PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.69760126
147TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.69630130

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis6.62939298
2MP0003646_muscle_fatigue6.15526939
3MP0000751_myopathy5.66066314
4MP0004084_abnormal_cardiac_muscle4.92974411
5MP0000749_muscle_degeneration4.73555906
6MP0004036_abnormal_muscle_relaxation4.30327724
7MP0004215_abnormal_myocardial_fiber4.15883065
8MP0004145_abnormal_muscle_electrophysio3.75638998
9MP0005330_cardiomyopathy3.57514442
10MP0004087_abnormal_muscle_fiber3.35743018
11MP0002106_abnormal_muscle_physiology3.09982039
12MP0000750_abnormal_muscle_regeneration3.09010591
13MP0005620_abnormal_muscle_contractility2.88909797
14MP0002972_abnormal_cardiac_muscle2.78424093
15MP0000747_muscle_weakness2.78127024
16MP0004130_abnormal_muscle_cell2.76894928
17MP0002269_muscular_atrophy2.73058378
18MP0000759_abnormal_skeletal_muscle2.56309095
19MP0005369_muscle_phenotype2.54618502
20MP0003137_abnormal_impulse_conducting2.45490020
21MP0008775_abnormal_heart_ventricle2.40632398
22MP0010630_abnormal_cardiac_muscle2.36646871
23MP0001544_abnormal_cardiovascular_syste2.26923255
24MP0005385_cardiovascular_system_phenoty2.26923255
25MP0004484_altered_response_of2.25278537
26MP0006138_congestive_heart_failure1.98301989
27MP0004233_abnormal_muscle_weight1.97683085
28MP0003221_abnormal_cardiomyocyte_apopto1.83234434
29MP0003828_pulmonary_edema1.77984247
30MP0006036_abnormal_mitochondrial_physio1.70922240
31MP0004510_myositis1.68531703
32MP0004085_abnormal_heartbeat1.68065088
33MP0002332_abnormal_exercise_endurance1.60935022
34MP0003950_abnormal_plasma_membrane1.55974953
35MP0005666_abnormal_adipose_tissue1.51983633
36MP0002127_abnormal_cardiovascular_syste1.42627220
37MP0002108_abnormal_muscle_morphology1.26759413
38MP0004185_abnormal_adipocyte_glucose1.25630813
39MP0005670_abnormal_white_adipose1.24088906
40MP0000733_abnormal_muscle_development1.23339557
41MP0002234_abnormal_pharynx_morphology1.09917523
42MP0005375_adipose_tissue_phenotype1.09010596
43MP0000343_altered_response_to1.05774479
44MP0001661_extended_life_span1.03782644
45MP0000266_abnormal_heart_morphology1.01404493
46MP0003567_abnormal_fetal_cardiomyocyte0.98862225
47MP0004270_analgesia0.97013836
48MP0006035_abnormal_mitochondrial_morpho0.94593278
49MP0003705_abnormal_hypodermis_morpholog0.87980383
50MP0005266_abnormal_metabolism0.87320404
51MP0005165_increased_susceptibility_to0.84691455
52MP0000013_abnormal_adipose_tissue0.84396180
53MP0003279_aneurysm0.81833246
54MP0010368_abnormal_lymphatic_system0.81624830
55MP0002971_abnormal_brown_adipose0.78536042
56MP0005275_abnormal_skin_tensile0.73622437
57MP0003806_abnormal_nucleotide_metabolis0.70592686
58MP0002128_abnormal_blood_circulation0.68375561
59MP0000003_abnormal_adipose_tissue0.66887361
60MP0000230_abnormal_systemic_arterial0.65416638
61MP0003566_abnormal_cell_adhesion0.60988592
62MP0005623_abnormal_meninges_morphology0.57824975
63MP0004043_abnormal_pH_regulation0.56340669
64MP0008438_abnormal_cutaneous_collagen0.52221693
65MP0002909_abnormal_adrenal_gland0.51802416
66MP0005451_abnormal_body_composition0.50501964
67MP0004147_increased_porphyrin_level0.50271424
68MP0000767_abnormal_smooth_muscle0.49326739
69MP0001879_abnormal_lymphatic_vessel0.49300246
70MP0002078_abnormal_glucose_homeostasis0.48715420
71MP0008961_abnormal_basal_metabolism0.48657567
72MP0000372_irregular_coat_pigmentation0.45713218
73MP0008004_abnormal_stomach_pH0.44901236
74MP0005319_abnormal_enzyme/_coenzyme0.44472838
75MP0005187_abnormal_penis_morphology0.42858803
76MP0002822_catalepsy0.40996241
77MP0003045_fibrosis0.40878161
78MP0005334_abnormal_fat_pad0.36802923
79MP0005167_abnormal_blood-brain_barrier0.36517749
80MP0002925_abnormal_cardiovascular_devel0.36348985
81MP0003879_abnormal_hair_cell0.33578900
82MP0004272_abnormal_basement_membrane0.32237510
83MP0003948_abnormal_gas_homeostasis0.30832387
84MP0000579_abnormal_nail_morphology0.30205192
85MP0002638_abnormal_pupillary_reflex0.29512991
86MP0001784_abnormal_fluid_regulation0.29456144
87MP0001614_abnormal_blood_vessel0.28689212
88MP0005535_abnormal_body_temperature0.28237233
89MP0009115_abnormal_fat_cell0.26375777
90MP0004134_abnormal_chest_morphology0.26367136
91MP0001984_abnormal_olfaction0.25585605
92MP0005166_decreased_susceptibility_to0.25122587
93MP0001299_abnormal_eye_distance/0.24563344
94MP0003656_abnormal_erythrocyte_physiolo0.24416992
95MP0005452_abnormal_adipose_tissue0.22764456
96MP0002118_abnormal_lipid_homeostasis0.22745343
97MP0005083_abnormal_biliary_tract0.22319167
98MP0003984_embryonic_growth_retardation0.22209700
99MP0005584_abnormal_enzyme/coenzyme_acti0.22093445
100MP0009780_abnormal_chondrocyte_physiolo0.21890449
101MP0009840_abnormal_foam_cell0.21777023
102MP0002088_abnormal_embryonic_growth/wei0.21156315
103MP0004142_abnormal_muscle_tone0.21029256
104MP0000762_abnormal_tongue_morphology0.21017317
105MP0005332_abnormal_amino_acid0.20470319
106MP0008569_lethality_at_weaning0.19635999
107MP0009384_cardiac_valve_regurgitation0.19603846
108MP0005423_abnormal_somatic_nervous0.19341335
109MP0009672_abnormal_birth_weight0.18517427
110MP0001853_heart_inflammation0.18457908
111MP0001958_emphysema0.17288595
112MP0002896_abnormal_bone_mineralization0.16825859
113MP0002877_abnormal_melanocyte_morpholog0.16569202
114MP0001727_abnormal_embryo_implantation0.16395485
115MP0005376_homeostasis/metabolism_phenot0.16279478
116MP0002970_abnormal_white_adipose0.16155885
117MP0004924_abnormal_behavior0.15222688
118MP0005386_behavior/neurological_phenoty0.15222688
119MP0002066_abnormal_motor_capabilities/c0.15083060
120MP0002114_abnormal_axial_skeleton0.14568255
121MP0008874_decreased_physiological_sensi0.14418489
122MP0000249_abnormal_blood_vessel0.13935344
123MP0010030_abnormal_orbit_morphology0.13928423
124MP0001943_abnormal_respiration0.12250233

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)7.17506798
2Sudden death (HP:0001699)7.00068258
3Calf muscle hypertrophy (HP:0008981)6.85313025
4Exercise-induced muscle cramps (HP:0003710)6.78605144
5Muscle hypertrophy of the lower extremities (HP:0008968)6.68847668
6Muscle fiber splitting (HP:0003555)6.43499200
7Muscle fiber inclusion bodies (HP:0100299)5.97023370
8Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.76958713
9Ventricular tachycardia (HP:0004756)5.69409562
10Hyporeflexia of lower limbs (HP:0002600)5.65821043
11Abnormality of the calf musculature (HP:0001430)5.46078398
12Myoglobinuria (HP:0002913)5.12102542
13Type 1 muscle fiber predominance (HP:0003803)5.09695772
14Nemaline bodies (HP:0003798)5.05237414
15Abnormality of the left ventricular outflow tract (HP:0011103)4.91033689
16Subaortic stenosis (HP:0001682)4.91033689
17EMG: myopathic abnormalities (HP:0003458)4.88150608
18Increased connective tissue (HP:0009025)4.65443843
19Atrial fibrillation (HP:0005110)4.63682271
20Difficulty running (HP:0009046)4.63302687
21Lipoatrophy (HP:0100578)4.45518122
22Primary atrial arrhythmia (HP:0001692)4.33254129
23Right ventricular cardiomyopathy (HP:0011663)4.21237940
24Supraventricular tachycardia (HP:0004755)4.18383027
25Supraventricular arrhythmia (HP:0005115)4.10022131
26Rhabdomyolysis (HP:0003201)4.04089199
27Myotonia (HP:0002486)3.93883850
28Asymmetric septal hypertrophy (HP:0001670)3.92770019
29Distal arthrogryposis (HP:0005684)3.82829852
30Dilated cardiomyopathy (HP:0001644)3.81261210
31Bundle branch block (HP:0011710)3.79979648
32Syncope (HP:0001279)3.64428337
33Difficulty climbing stairs (HP:0003551)3.50439728
34Palpitations (HP:0001962)3.47424942
35Myopathic facies (HP:0002058)3.42552541
36Prolonged QT interval (HP:0001657)3.40899515
37Muscle stiffness (HP:0003552)3.38520888
38Round ear (HP:0100830)3.35189454
39Ventricular arrhythmia (HP:0004308)3.27559350
40Abnormality of skeletal muscle fiber size (HP:0012084)3.26414954
41Neck muscle weakness (HP:0000467)3.23714033
42Increased variability in muscle fiber diameter (HP:0003557)3.22422650
43Heart block (HP:0012722)3.14075321
44Areflexia of lower limbs (HP:0002522)3.03005006
45Abnormal atrioventricular conduction (HP:0005150)2.97986350
46Atrioventricular block (HP:0001678)2.94516759
47Rimmed vacuoles (HP:0003805)2.90596082
48Distal lower limb muscle weakness (HP:0009053)2.88804473
49Ventricular fibrillation (HP:0001663)2.82911372
50Ulnar deviation of the wrist (HP:0003049)2.78891493
51Limb-girdle muscle atrophy (HP:0003797)2.56960721
52Mildly elevated creatine phosphokinase (HP:0008180)2.54596642
53EMG: neuropathic changes (HP:0003445)2.46012315
54Abnormal EKG (HP:0003115)2.44349879
55Abnormal finger flexion creases (HP:0006143)2.37808698
56Frequent falls (HP:0002359)2.37369148
57Left ventricular hypertrophy (HP:0001712)2.37218087
58Distal lower limb amyotrophy (HP:0008944)2.36772091
59Muscular dystrophy (HP:0003560)2.34455008
60Hypoplastic ischia (HP:0003175)2.30830131
61Gowers sign (HP:0003391)2.29571428
62Generalized muscle weakness (HP:0003324)2.27327362
63Testicular atrophy (HP:0000029)2.26833832
64Facial diplegia (HP:0001349)2.26096484
65Palmoplantar keratoderma (HP:0000982)2.24439475
66Calcaneovalgus deformity (HP:0001848)2.22991008
67Scapular winging (HP:0003691)2.21929009
68Ketoacidosis (HP:0001993)2.17539147
69Slender build (HP:0001533)2.17057862
70Hepatic necrosis (HP:0002605)2.13707385
71Abnormal mitochondria in muscle tissue (HP:0008316)2.12182062
72Centrally nucleated skeletal muscle fibers (HP:0003687)2.11094086
73Absent phalangeal crease (HP:0006109)2.09487160
74Abnormality of the shoulder girdle musculature (HP:0001435)2.09484652
75Proximal amyotrophy (HP:0007126)2.09005036
76Abnormality of the foot musculature (HP:0001436)2.08329465
77Hyperkalemia (HP:0002153)2.05893567
78Acute necrotizing encephalopathy (HP:0006965)2.05390844
79Deformed tarsal bones (HP:0008119)2.04581257
80Fetal akinesia sequence (HP:0001989)2.03369956
81Progressive muscle weakness (HP:0003323)2.02241258
82Foot dorsiflexor weakness (HP:0009027)2.01578724
83Abnormality of the ischium (HP:0003174)2.00693746
84Waddling gait (HP:0002515)1.97511018
85Increased muscle lipid content (HP:0009058)1.96959490
86Fatigable weakness (HP:0003473)1.94948011
87Abnormality of the neuromuscular junction (HP:0003398)1.94948011
88Respiratory insufficiency due to muscle weakness (HP:0002747)1.93663704
89Limb-girdle muscle weakness (HP:0003325)1.93289198
90Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.90922881
91Spinal rigidity (HP:0003306)1.89419077
92Conjunctival hamartoma (HP:0100780)1.88838636
93Bulbar palsy (HP:0001283)1.87790832
94Hepatocellular necrosis (HP:0001404)1.86282548
95Malignant hyperthermia (HP:0002047)1.85983761
96Hypoglycemic coma (HP:0001325)1.85857247
97Exercise intolerance (HP:0003546)1.81231745
98Hip contracture (HP:0003273)1.80942787
99Lower limb amyotrophy (HP:0007210)1.80714815
100Acute encephalopathy (HP:0006846)1.77297508
101Abnormality of fatty-acid metabolism (HP:0004359)1.75278122
102Steppage gait (HP:0003376)1.74157935
103Ragged-red muscle fibers (HP:0003200)1.73021523
104Large for gestational age (HP:0001520)1.71927421
105Weak cry (HP:0001612)1.71698994
106Increased intramyocellular lipid droplets (HP:0012240)1.70964906
107Congestive heart failure (HP:0001635)1.70577145
108Dicarboxylic aciduria (HP:0003215)1.70568034
109Abnormality of the hip-girdle musculature (HP:0001445)1.69870079
110Abnormality of the musculature of the pelvis (HP:0001469)1.69870079
111Abnormality of the calcaneus (HP:0008364)1.66173179
112Shoulder girdle muscle weakness (HP:0003547)1.65984771
113Pelvic girdle muscle weakness (HP:0003749)1.65282934
114Nonprogressive disorder (HP:0003680)1.47449336
115Long clavicles (HP:0000890)1.45551473
116Dysmetric saccades (HP:0000641)1.44032889
117Oligomenorrhea (HP:0000876)1.41351440

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN6.76592967
2TTN6.44130616
3PHKG14.63999303
4PHKG24.63999303
5PDK43.04920699
6PDK33.04920699
7DMPK2.98676677
8LMTK22.77691876
9TRIB32.65725981
10MUSK2.53405986
11MYLK2.41374058
12PKN22.35829935
13NEK12.30296519
14BCKDK2.17285678
15PINK12.09856038
16PIK3CA2.07479401
17PDK21.87855254
18NME11.75514119
19PIK3CG1.63680305
20TIE11.58457244
21MAP2K31.52367171
22MAP3K71.46891910
23STK241.33329116
24MAPK121.25198946
25MARK11.16655589
26MAPKAPK31.07492439
27PRKD11.05469267
28CAMK2D1.00969200
29ILK0.98478780
30GRK70.97645844
31ZAK0.94990312
32LIMK10.94028141
33PAK30.93154211
34PRKAA10.89355848
35RIPK10.86867271
36PRKAA20.86734866
37ROCK10.84858436
38CCNB10.84439347
39MAP3K30.84244537
40TRPM70.81388817
41INSRR0.77906094
42MAP3K50.74770264
43EPHB10.74380484
44PKN10.74161707
45ERBB30.72630588
46MAPK40.64890194
47CDC42BPA0.61597877
48PDGFRA0.57312215
49STK40.56061569
50FLT30.55701728
51AKT20.53311190
52STK38L0.53196183
53NEK90.52843155
54EPHA30.51724083
55CAMK2B0.51563800
56MOS0.51507049
57MAP2K40.51339998
58SIK10.50571314
59WNK40.49861433
60TGFBR20.49223104
61ROCK20.49165842
62MAP2K60.47838876
63MAP3K60.47634673
64STK380.47559902
65CAMK40.47167071
66KSR20.45722146
67PRKACB0.45135039
68DAPK30.44430448
69MAP2K10.44344625
70DYRK1B0.42666537
71CAMK2G0.42253628
72CAMK2A0.41640532
73ICK0.41603740
74SGK20.41056836
75PTK60.38724498
76TBK10.38444082
77WNK10.38193942
78RPS6KL10.36780294
79RPS6KC10.36780294
80TAOK10.35229525
81KDR0.34792642
82PRKACA0.34284537
83PTK2B0.34158771
84PDPK10.33064196
85MAPK110.30732626
86MAP3K130.30002761
87RPS6KA60.29955898
88PRKACG0.29745697
89CAMK10.27464963
90LATS10.27174071
91MARK20.25905780
92PDK10.25080169
93MAPK100.24976888
94PRKG10.23544510
95PRKG20.23333300
96RPS6KA10.22184636
97MTOR0.22109604
98SGK10.21738634
99PRKCE0.21520025
100MAP3K110.21265415
101PRKCH0.20764093
102LATS20.20224369
103FER0.19582960
104SGK2230.19217755
105SGK4940.19217755
106RPS6KA30.18745270
107SGK30.18256837
108STK110.18089661
109MAP3K10.17361712
110RPS6KB10.17055709
111MAPK70.16674827
112ZAP700.15734035
113FGFR30.15341176
114RET0.15122572
115JAK10.15009291
116UHMK10.14914567
117RAF10.14410884
118EEF2K0.13993495
119LRRK20.13853905
120NLK0.13593117
121FGFR40.12903850
122EPHB20.12303746
123MAP3K100.12157534
124MARK30.10804059
125RPS6KA20.10324566
126PRKD30.09998117
127PAK60.09996981
128RPS6KB20.09846654
129TAOK20.09826484
130MAPK130.09307117

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.57330334
2Cardiac muscle contraction_Homo sapiens_hsa042604.27895213
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.19119288
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.09636851
5Dilated cardiomyopathy_Homo sapiens_hsa054144.00662562
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.28386844
7Propanoate metabolism_Homo sapiens_hsa006403.05177208
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.95394809
9Parkinsons disease_Homo sapiens_hsa050122.71269277
10Fatty acid degradation_Homo sapiens_hsa000712.61193290
11Oxidative phosphorylation_Homo sapiens_hsa001902.57606474
12Carbon metabolism_Homo sapiens_hsa012002.37845368
13Alzheimers disease_Homo sapiens_hsa050102.09678752
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.06200764
15Fatty acid metabolism_Homo sapiens_hsa012121.95368301
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.94750641
17Viral myocarditis_Homo sapiens_hsa054161.90315758
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.84840851
19Pyruvate metabolism_Homo sapiens_hsa006201.68205213
20Huntingtons disease_Homo sapiens_hsa050161.57152224
21Starch and sucrose metabolism_Homo sapiens_hsa005001.47598096
22Insulin resistance_Homo sapiens_hsa049311.35570112
23Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.34573438
24Glucagon signaling pathway_Homo sapiens_hsa049221.31008068
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.30585095
26Insulin signaling pathway_Homo sapiens_hsa049101.24238406
27Adipocytokine signaling pathway_Homo sapiens_hsa049201.21258714
28Butanoate metabolism_Homo sapiens_hsa006501.18347445
29Biosynthesis of amino acids_Homo sapiens_hsa012301.15028351
30cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07460077
31PPAR signaling pathway_Homo sapiens_hsa033201.02942831
32Fatty acid elongation_Homo sapiens_hsa000621.02181355
33Oxytocin signaling pathway_Homo sapiens_hsa049210.97014385
34Calcium signaling pathway_Homo sapiens_hsa040200.95303235
35AMPK signaling pathway_Homo sapiens_hsa041520.94827129
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.92706106
37Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.91977575
38Focal adhesion_Homo sapiens_hsa045100.84990957
39Arginine biosynthesis_Homo sapiens_hsa002200.80997828
40Arginine and proline metabolism_Homo sapiens_hsa003300.79172239
41Tight junction_Homo sapiens_hsa045300.78834580
42Galactose metabolism_Homo sapiens_hsa000520.76862167
43HIF-1 signaling pathway_Homo sapiens_hsa040660.72434741
44Vascular smooth muscle contraction_Homo sapiens_hsa042700.72143994
45Lysine degradation_Homo sapiens_hsa003100.70452440
46Circadian rhythm_Homo sapiens_hsa047100.70027146
47Type II diabetes mellitus_Homo sapiens_hsa049300.68130320
48Tryptophan metabolism_Homo sapiens_hsa003800.67462817
49beta-Alanine metabolism_Homo sapiens_hsa004100.67237010
50Fructose and mannose metabolism_Homo sapiens_hsa000510.63080795
51Fatty acid biosynthesis_Homo sapiens_hsa000610.61348080
52Long-term potentiation_Homo sapiens_hsa047200.60918597
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58982514
54Central carbon metabolism in cancer_Homo sapiens_hsa052300.56377722
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.55487733
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.54654817
57Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53316979
58Gastric acid secretion_Homo sapiens_hsa049710.52202077
59Renin secretion_Homo sapiens_hsa049240.51876195
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49731762
61Nitrogen metabolism_Homo sapiens_hsa009100.48901707
62Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48443636
63ECM-receptor interaction_Homo sapiens_hsa045120.46789824
64Phenylalanine metabolism_Homo sapiens_hsa003600.46501658
65Insulin secretion_Homo sapiens_hsa049110.43424569
66Adherens junction_Homo sapiens_hsa045200.43273179
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40578301
68Amoebiasis_Homo sapiens_hsa051460.40078215
69Salivary secretion_Homo sapiens_hsa049700.39552922
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38932154
71cAMP signaling pathway_Homo sapiens_hsa040240.36610430
72Peroxisome_Homo sapiens_hsa041460.35968548
73GnRH signaling pathway_Homo sapiens_hsa049120.33726286
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33051423
75Amphetamine addiction_Homo sapiens_hsa050310.32363504
76VEGF signaling pathway_Homo sapiens_hsa043700.30212295
77Regulation of autophagy_Homo sapiens_hsa041400.30093634
78mTOR signaling pathway_Homo sapiens_hsa041500.29027775
79Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28017920
80Aldosterone synthesis and secretion_Homo sapiens_hsa049250.27959134
81Leukocyte transendothelial migration_Homo sapiens_hsa046700.26342705
82Melanogenesis_Homo sapiens_hsa049160.26211892
83Platelet activation_Homo sapiens_hsa046110.25731887
84Renal cell carcinoma_Homo sapiens_hsa052110.24989432
85Proteoglycans in cancer_Homo sapiens_hsa052050.24332689
86FoxO signaling pathway_Homo sapiens_hsa040680.23149836
87Circadian entrainment_Homo sapiens_hsa047130.20249722
88Fat digestion and absorption_Homo sapiens_hsa049750.18897079
89Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.18055266
90Olfactory transduction_Homo sapiens_hsa047400.17868110
91Dorso-ventral axis formation_Homo sapiens_hsa043200.17549257
92Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.17117918
93Metabolic pathways_Homo sapiens_hsa011000.16240731
94MAPK signaling pathway_Homo sapiens_hsa040100.15905444
95Histidine metabolism_Homo sapiens_hsa003400.15478565
96Pancreatic secretion_Homo sapiens_hsa049720.14884208
97Pentose phosphate pathway_Homo sapiens_hsa000300.14046728
98Purine metabolism_Homo sapiens_hsa002300.13665119
99Long-term depression_Homo sapiens_hsa047300.12503922
100Ovarian steroidogenesis_Homo sapiens_hsa049130.12010645
101Cysteine and methionine metabolism_Homo sapiens_hsa002700.10975272
102Tyrosine metabolism_Homo sapiens_hsa003500.10432881
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.10354382
104Cholinergic synapse_Homo sapiens_hsa047250.09838233
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.09315740
106Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.08815907
107Gap junction_Homo sapiens_hsa045400.08667461
108Bile secretion_Homo sapiens_hsa049760.08547092
109Neurotrophin signaling pathway_Homo sapiens_hsa047220.08066706
110Sulfur relay system_Homo sapiens_hsa041220.07428504
111Toxoplasmosis_Homo sapiens_hsa051450.05943415
112Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.03617518
113Notch signaling pathway_Homo sapiens_hsa043300.03059221
114Glycerolipid metabolism_Homo sapiens_hsa005610.02882185
115Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.01806505
116ABC transporters_Homo sapiens_hsa020100.00457518

Most similar genes based on co-expression Upload to Enrichr

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