NR6A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an orphan nuclear receptor which is a member of the nuclear hormone receptor family. Its expression pattern suggests that it may be involved in neurogenesis and germ cell development. The protein can homodimerize and bind DNA, but in vivo targets have not been identified. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of gene silencing by miRNA (GO:0060964)5.21679615
2regulation of gene silencing by RNA (GO:0060966)5.21679615
3regulation of posttranscriptional gene silencing (GO:0060147)5.21679615
4paraxial mesoderm development (GO:0048339)4.93470989
5nuclear pore complex assembly (GO:0051292)4.68469441
6nuclear pore organization (GO:0006999)4.63087497
7meiotic chromosome segregation (GO:0045132)4.49543474
8mitotic metaphase plate congression (GO:0007080)4.44999135
9kinetochore assembly (GO:0051382)4.34006954
10DNA double-strand break processing (GO:0000729)4.32134031
11IMP biosynthetic process (GO:0006188)4.31043333
12kinetochore organization (GO:0051383)4.28654605
13microtubule depolymerization (GO:0007019)4.24879198
14regulation of centriole replication (GO:0046599)4.18938498
15pre-miRNA processing (GO:0031054)4.18498631
16proteasome assembly (GO:0043248)4.07862092
17L-serine metabolic process (GO:0006563)4.03922030
18pore complex assembly (GO:0046931)4.00182140
19protein K6-linked ubiquitination (GO:0085020)4.00114795
20purine nucleobase biosynthetic process (GO:0009113)3.94937116
21piRNA metabolic process (GO:0034587)3.94441456
22chromatin remodeling at centromere (GO:0031055)3.93878362
23metaphase plate congression (GO:0051310)3.93766657
24CENP-A containing nucleosome assembly (GO:0034080)3.82451044
25negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.81315190
26regulation of telomere maintenance via telomerase (GO:0032210)3.77903825
27histone exchange (GO:0043486)3.76448699
28IMP metabolic process (GO:0046040)3.74979468
29regulation of nuclear cell cycle DNA replication (GO:0033262)3.73897963
30telomere maintenance via semi-conservative replication (GO:0032201)3.72987005
31nucleobase biosynthetic process (GO:0046112)3.66548010
32regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.66413138
33mitotic spindle checkpoint (GO:0071174)3.66206213
34establishment of protein localization to mitochondrial membrane (GO:0090151)3.58716433
35DNA replication initiation (GO:0006270)3.57915009
36regulation of helicase activity (GO:0051095)3.57202733
37regulation of meiosis I (GO:0060631)3.57160119
38DNA replication checkpoint (GO:0000076)3.54320173
39regulation of double-strand break repair via homologous recombination (GO:0010569)3.53817461
40DNA catabolic process, exonucleolytic (GO:0000738)3.50790829
41establishment of viral latency (GO:0019043)3.48551062
42attachment of spindle microtubules to kinetochore (GO:0008608)3.46103850
43replication fork processing (GO:0031297)3.46003405
44motile cilium assembly (GO:0044458)3.44706848
45protein localization to chromosome, centromeric region (GO:0071459)3.44606607
46DNA replication-independent nucleosome organization (GO:0034724)3.44253959
47DNA replication-independent nucleosome assembly (GO:0006336)3.44253959
48negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.42527767
49negative regulation of ligase activity (GO:0051352)3.42527767
50DNA ligation (GO:0006266)3.41691035
51DNA replication-dependent nucleosome assembly (GO:0006335)3.41363272
52DNA replication-dependent nucleosome organization (GO:0034723)3.41363272
53negative regulation of DNA recombination (GO:0045910)3.40823702
54DNA methylation involved in gamete generation (GO:0043046)3.38600134
55chaperone-mediated protein transport (GO:0072321)3.36981514
56anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.36614713
57mitotic sister chromatid segregation (GO:0000070)3.36300710
58male meiosis (GO:0007140)3.34888978
59mitotic spindle assembly checkpoint (GO:0007094)3.31834483
60exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.30249412
61establishment of chromosome localization (GO:0051303)3.28823782
62positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.28563700
63ncRNA catabolic process (GO:0034661)3.28166908
64DNA damage response, detection of DNA damage (GO:0042769)3.27256498
65centriole replication (GO:0007099)3.26371779
66centriole assembly (GO:0098534)3.26306662
67cullin deneddylation (GO:0010388)3.26292270
68regulation of histone H3-K9 methylation (GO:0051570)3.26154658
69spindle assembly checkpoint (GO:0071173)3.24270784
70nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.23205447
71protein neddylation (GO:0045116)3.22113964
72response to X-ray (GO:0010165)3.21493777
73heterochromatin organization (GO:0070828)3.21458442
74negative regulation of translation, ncRNA-mediated (GO:0040033)3.20989466
75regulation of translation, ncRNA-mediated (GO:0045974)3.20989466
76negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.20989466
77regulation of centrosome cycle (GO:0046605)3.20829585
78double-strand break repair via nonhomologous end joining (GO:0006303)3.20314758
79non-recombinational repair (GO:0000726)3.20314758
80regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.20205921
81regulation of mitotic spindle checkpoint (GO:1903504)3.20205921
82reciprocal DNA recombination (GO:0035825)3.19580126
83reciprocal meiotic recombination (GO:0007131)3.19580126
84telomere maintenance via recombination (GO:0000722)3.19520227
85synapsis (GO:0007129)3.19257008
86regulation of mitotic sister chromatid separation (GO:0010965)3.19256639
87mitotic recombination (GO:0006312)3.17260626
88negative regulation of DNA-dependent DNA replication (GO:2000104)3.16990915
89somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.16804428
90isotype switching (GO:0045190)3.16804428
91somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.16804428
92telomere maintenance via telomerase (GO:0007004)3.16323428
93protein localization to kinetochore (GO:0034501)3.15717039
94negative regulation of mitosis (GO:0045839)3.13708098
95female gonad development (GO:0008585)3.13680517
96mitotic nuclear envelope disassembly (GO:0007077)3.11775550
97telomere maintenance via telomere lengthening (GO:0010833)3.11710057
98DNA strand renaturation (GO:0000733)3.10059332
99chromosome organization involved in meiosis (GO:0070192)3.09445780
100intra-S DNA damage checkpoint (GO:0031573)3.09377757
101binding of sperm to zona pellucida (GO:0007339)3.08520210
102protein deneddylation (GO:0000338)3.07768692
103axonemal dynein complex assembly (GO:0070286)3.07701859
104regulation of gene silencing (GO:0060968)3.05762547
105regulation of spindle checkpoint (GO:0090231)3.05560693
106sperm-egg recognition (GO:0035036)3.04588651
107DNA strand elongation involved in DNA replication (GO:0006271)3.03284487
108termination of RNA polymerase III transcription (GO:0006386)3.01674515
109transcription elongation from RNA polymerase III promoter (GO:0006385)3.01674515
110ribosome biogenesis (GO:0042254)3.01235388
111regulation of double-strand break repair (GO:2000779)3.01128033
112RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.00934889
113microtubule polymerization or depolymerization (GO:0031109)2.97956844
114maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.96267405
115establishment of integrated proviral latency (GO:0075713)2.95421418
116mismatch repair (GO:0006298)2.94001143
117ATP-dependent chromatin remodeling (GO:0043044)2.93717923
118lysine catabolic process (GO:0006554)2.93460821
119lysine metabolic process (GO:0006553)2.93460821
120DNA strand elongation (GO:0022616)2.92447945
121rRNA modification (GO:0000154)2.90153288
122synaptonemal complex assembly (GO:0007130)2.89688467
123somatic recombination of immunoglobulin gene segments (GO:0016447)2.89314577
124inner cell mass cell proliferation (GO:0001833)2.88167191
125negative regulation of chromosome segregation (GO:0051985)2.86988771
126snRNA processing (GO:0016180)2.86224416
127spindle checkpoint (GO:0031577)2.85987203
128protein complex localization (GO:0031503)2.84946286
129spliceosomal snRNP assembly (GO:0000387)2.84491402
130negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.84067658
131ribosome assembly (GO:0042255)2.83812312
132negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.83784408
133negative regulation of sister chromatid segregation (GO:0033046)2.83784408
134negative regulation of mitotic sister chromatid separation (GO:2000816)2.83784408
135negative regulation of mitotic sister chromatid segregation (GO:0033048)2.83784408
136meiotic cell cycle process (GO:1903046)2.83707474
137monoubiquitinated protein deubiquitination (GO:0035520)2.83137055
138nuclear envelope disassembly (GO:0051081)2.83123667
139membrane disassembly (GO:0030397)2.83123667
140DNA synthesis involved in DNA repair (GO:0000731)2.82510057
141somatic diversification of immune receptors via somatic mutation (GO:0002566)2.82298606
142somatic hypermutation of immunoglobulin genes (GO:0016446)2.82298606
143histone H4-K12 acetylation (GO:0043983)2.82187694
144cilium or flagellum-dependent cell motility (GO:0001539)2.80145428
145regulation of spindle organization (GO:0090224)2.79952574
146regulation of chromosome segregation (GO:0051983)2.78445564
147regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.77700708
148regulation of mitotic metaphase/anaphase transition (GO:0030071)2.77335262
149DNA unwinding involved in DNA replication (GO:0006268)2.76965988
150sister chromatid segregation (GO:0000819)2.76523741
151protein localization to chromosome (GO:0034502)2.75734329
152meiotic nuclear division (GO:0007126)2.75703443
153chromosome segregation (GO:0007059)2.75472503
154regulation of sister chromatid segregation (GO:0033045)2.74304854
155regulation of mitotic sister chromatid segregation (GO:0033047)2.74304854

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.60911142
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.54164972
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.21938322
4E2F4_17652178_ChIP-ChIP_JURKAT_Human4.04124354
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.63434806
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.60111951
7KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.70257806
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.60587797
9* TP63_19390658_ChIP-ChIP_HaCaT_Human2.52052949
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.48683517
11* MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.47438028
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.46067842
13KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.40371569
14KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.40371569
15KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.40371569
16MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.32994821
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.26325211
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.22256282
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.10384655
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.09715632
21* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.02241107
22SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.91612810
23RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.91187171
24NANOG_18555785_ChIP-Seq_MESCs_Mouse1.90449254
25AR_21909140_ChIP-Seq_LNCAP_Human1.86876889
26EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.86795376
27MYCN_18555785_ChIP-Seq_MESCs_Mouse1.83921729
28JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.82516847
29SOX2_18555785_ChIP-Seq_MESCs_Mouse1.79008080
30NELFA_20434984_ChIP-Seq_ESCs_Mouse1.78184611
31NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.78113358
32* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.74592970
33* E2F1_21310950_ChIP-Seq_MCF-7_Human1.71755712
34ZNF274_21170338_ChIP-Seq_K562_Hela1.71253626
35YY1_21170310_ChIP-Seq_MESCs_Mouse1.70265087
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.67502450
37* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.67100684
38NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.59225060
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.58867457
40HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.58128090
41* ETS1_20019798_ChIP-Seq_JURKAT_Human1.56007534
42* TTF2_22483619_ChIP-Seq_HELA_Human1.55948275
43POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.47443040
44XRN2_22483619_ChIP-Seq_HELA_Human1.46779522
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.44603666
46NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.44465212
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44402392
48* FOXP3_21729870_ChIP-Seq_TREG_Human1.42026670
49MYC_18940864_ChIP-ChIP_HL60_Human1.41798642
50ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.41251499
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.40488260
52GABP_17652178_ChIP-ChIP_JURKAT_Human1.40338795
53FLI1_27457419_Chip-Seq_LIVER_Mouse1.38231855
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.38108683
55SRF_21415370_ChIP-Seq_HL-1_Mouse1.34337637
56HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.33747235
57* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.32960765
58ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.32351247
59VDR_23849224_ChIP-Seq_CD4+_Human1.32243717
60* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.31533977
61ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30992538
62KAP1_22055183_ChIP-Seq_ESCs_Mouse1.30731556
63FUS_26573619_Chip-Seq_HEK293_Human1.26600929
64GATA1_26923725_Chip-Seq_HPCs_Mouse1.24314375
65NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.23396421
66* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.22414288
67CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.21740794
68PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.21236280
69HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.20333452
70PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19735678
71* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.19194387
72PADI4_21655091_ChIP-ChIP_MCF-7_Human1.18880395
73IRF1_19129219_ChIP-ChIP_H3396_Human1.16116833
74P300_19829295_ChIP-Seq_ESCs_Human1.15247713
75RBPJ_22232070_ChIP-Seq_NCS_Mouse1.12898356
76ELK1_19687146_ChIP-ChIP_HELA_Human1.12221058
77ELF1_17652178_ChIP-ChIP_JURKAT_Human1.12150387
78POU5F1_16518401_ChIP-PET_MESCs_Mouse1.12138729
79PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07407120
80* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.07178113
81* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.07009870
82KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.06986954
83RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.03972919
84SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.02748434
85GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02670527
86* NANOG_16153702_ChIP-ChIP_HESCs_Human1.02283730
87VDR_22108803_ChIP-Seq_LS180_Human1.02049108
88* SOX2_16153702_ChIP-ChIP_HESCs_Human1.01907004
89* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.01398239
90NFE2_27457419_Chip-Seq_LIVER_Mouse1.01360132
91RNF2_27304074_Chip-Seq_NSC_Mouse1.00824383
92ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.99783494
93ZFX_18555785_ChIP-Seq_MESCs_Mouse0.99450255
94DCP1A_22483619_ChIP-Seq_HELA_Human0.99155537
95SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.97698016
96BMI1_23680149_ChIP-Seq_NPCS_Mouse0.96083726
97* THAP11_20581084_ChIP-Seq_MESCs_Mouse0.95952891
98* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.95093573
99EWS_26573619_Chip-Seq_HEK293_Human0.94536543
100GABP_19822575_ChIP-Seq_HepG2_Human0.93103334
101SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.92684415
102NOTCH1_21737748_ChIP-Seq_TLL_Human0.91383714
103SUZ12_27294783_Chip-Seq_NPCs_Mouse0.90397748
104IGF1R_20145208_ChIP-Seq_DFB_Human0.90243476
105FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.90072468
106KDM5A_27292631_Chip-Seq_BREAST_Human0.89740652
107* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.88346869
108* NANOG_18692474_ChIP-Seq_MESCs_Mouse0.86410313
109TAF15_26573619_Chip-Seq_HEK293_Human0.86262148
110PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.84181050
111* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.83585301
112HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.83535173
113* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.83381330
114SOX17_20123909_ChIP-Seq_XEN_Mouse0.81604910
115* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.78475182
116EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.78403742
117E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.77469209
118MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.77123893
119DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.76862495
120POU3F2_20337985_ChIP-ChIP_501MEL_Human0.76074696
121GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.74963134

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.14780299
2MP0010094_abnormal_chromosome_stability3.75788171
3MP0008058_abnormal_DNA_repair3.61801792
4MP0003111_abnormal_nucleus_morphology3.43169287
5MP0008877_abnormal_DNA_methylation3.38928719
6MP0006292_abnormal_olfactory_placode3.20408929
7MP0008057_abnormal_DNA_replication3.20010867
8MP0003077_abnormal_cell_cycle2.93306854
9MP0004957_abnormal_blastocyst_morpholog2.89292410
10MP0010030_abnormal_orbit_morphology2.83614863
11MP0002653_abnormal_ependyma_morphology2.82751312
12MP0003890_abnormal_embryonic-extraembry2.68214376
13MP0003941_abnormal_skin_development2.46653118
14MP0005410_abnormal_fertilization2.44708284
15MP0008007_abnormal_cellular_replicative2.44663328
16MP0002254_reproductive_system_inflammat2.34697295
17MP0008932_abnormal_embryonic_tissue2.30659234
18MP0003718_maternal_effect2.28207430
19MP0000566_synostosis2.17300860
20MP0002210_abnormal_sex_determination2.02517979
21* MP0001929_abnormal_gametogenesis1.99320303
22MP0003315_abnormal_perineum_morphology1.97769195
23MP0003786_premature_aging1.84390882
24MP0004133_heterotaxia1.84013795
25MP0003937_abnormal_limbs/digits/tail_de1.81045898
26MP0002160_abnormal_reproductive_system1.80287073
27MP0003123_paternal_imprinting1.79657508
28MP0003122_maternal_imprinting1.74564657
29MP0003698_abnormal_male_reproductive1.72395310
30MP0001293_anophthalmia1.71975908
31MP0002102_abnormal_ear_morphology1.68238934
32* MP0003119_abnormal_digestive_system1.66584830
33MP0003136_yellow_coat_color1.63564045
34MP0001145_abnormal_male_reproductive1.63252598
35MP0001730_embryonic_growth_arrest1.62374005
36MP0008789_abnormal_olfactory_epithelium1.57500160
37* MP0005380_embryogenesis_phenotype1.55618758
38* MP0001672_abnormal_embryogenesis/_devel1.55618758
39* MP0000653_abnormal_sex_gland1.54004412
40* MP0002085_abnormal_embryonic_tissue1.52507424
41MP0003121_genomic_imprinting1.51766370
42MP0000049_abnormal_middle_ear1.49994919
43MP0000350_abnormal_cell_proliferation1.48687753
44* MP0002084_abnormal_developmental_patter1.43922451
45MP0001697_abnormal_embryo_size1.37589541
46MP0009672_abnormal_birth_weight1.36707562
47MP0001529_abnormal_vocalization1.34322144
48MP0003787_abnormal_imprinting1.32713303
49MP0004197_abnormal_fetal_growth/weight/1.32271881
50MP0006035_abnormal_mitochondrial_morpho1.32252562
51MP0003195_calcinosis1.30278444
52MP0008995_early_reproductive_senescence1.29965324
53MP0001188_hyperpigmentation1.29604909
54MP0009703_decreased_birth_body1.29215062
55MP0002111_abnormal_tail_morphology1.27105097
56MP0003984_embryonic_growth_retardation1.23782431
57MP0005367_renal/urinary_system_phenotyp1.23451692
58MP0000516_abnormal_urinary_system1.23451692
59MP0002736_abnormal_nociception_after1.23263873
60MP0004147_increased_porphyrin_level1.22807912
61MP0005499_abnormal_olfactory_system1.21768076
62MP0005394_taste/olfaction_phenotype1.21768076
63MP0002088_abnormal_embryonic_growth/wei1.20081934
64MP0009053_abnormal_anal_canal1.18417341
65MP0005389_reproductive_system_phenotype1.17649049
66MP0001286_abnormal_eye_development1.17578716
67MP0000432_abnormal_head_morphology1.14291289
68* MP0002161_abnormal_fertility/fecundity1.12207828
69MP0010307_abnormal_tumor_latency1.11911372
70* MP0001119_abnormal_female_reproductive1.11809399
71MP0002249_abnormal_larynx_morphology1.10927313
72MP0003938_abnormal_ear_development1.09391845
73MP0000537_abnormal_urethra_morphology1.07566855
74MP0002638_abnormal_pupillary_reflex1.07152694
75MP0006072_abnormal_retinal_apoptosis1.06411268
76MP0002233_abnormal_nose_morphology1.05375527
77MP0003646_muscle_fatigue1.01550312
78MP0005451_abnormal_body_composition1.00427549
79MP0000313_abnormal_cell_death0.98365698
80MP0000579_abnormal_nail_morphology0.97726712
81* MP0002086_abnormal_extraembryonic_tissu0.96442204
82MP0003755_abnormal_palate_morphology0.95649959
83* MP0002080_prenatal_lethality0.95070335
84MP0003567_abnormal_fetal_cardiomyocyte0.94397090
85MP0003011_delayed_dark_adaptation0.93864311
86MP0001177_atelectasis0.93240690
87MP0003186_abnormal_redox_activity0.93037078
88MP0002697_abnormal_eye_size0.92849472
89* MP0003861_abnormal_nervous_system0.92576685
90MP0003936_abnormal_reproductive_system0.88445865
91MP0000647_abnormal_sebaceous_gland0.88174677
92MP0000026_abnormal_inner_ear0.87183775
93MP0003880_abnormal_central_pattern0.86316596
94MP0002116_abnormal_craniofacial_bone0.85754969
95MP0003935_abnormal_craniofacial_develop0.85339178
96MP0000490_abnormal_crypts_of0.85221058
97MP0003950_abnormal_plasma_membrane0.83477946
98MP0002751_abnormal_autonomic_nervous0.83130884
99MP0001984_abnormal_olfaction0.81662017
100MP0000428_abnormal_craniofacial_morphol0.80335419
101MP0000613_abnormal_salivary_gland0.79296216
102* MP0003699_abnormal_female_reproductive0.76701938
103MP0005391_vision/eye_phenotype0.75590979
104MP0002092_abnormal_eye_morphology0.75268757
105MP0009697_abnormal_copulation0.74309040
106MP0005075_abnormal_melanosome_morpholog0.73618864
107MP0002932_abnormal_joint_morphology0.73294796
108MP0002938_white_spotting0.72967923
109MP0001299_abnormal_eye_distance/0.72812915
110MP0002090_abnormal_vision0.72331437
111MP0006036_abnormal_mitochondrial_physio0.71910138
112MP0000678_abnormal_parathyroid_gland0.71504173
113MP0003878_abnormal_ear_physiology0.71381452
114MP0005377_hearing/vestibular/ear_phenot0.71381452
115MP0005076_abnormal_cell_differentiation0.71003288
116MP0005084_abnormal_gallbladder_morpholo0.70095561
117* MP0002114_abnormal_axial_skeleton0.69682008
118MP0010352_gastrointestinal_tract_polyps0.69591348
119MP0005253_abnormal_eye_physiology0.69089965
120MP0005395_other_phenotype0.68531922
121MP0001485_abnormal_pinna_reflex0.68304071
122MP0004233_abnormal_muscle_weight0.68159659
123MP0002177_abnormal_outer_ear0.68011694
124MP0000631_abnormal_neuroendocrine_gland0.67635192
125MP0004215_abnormal_myocardial_fiber0.65040276
126MP0003137_abnormal_impulse_conducting0.62579303

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.32959364
2Chromsome breakage (HP:0040012)5.00181339
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.93240361
4Rib fusion (HP:0000902)3.84154833
5Aplasia/Hypoplasia of the uvula (HP:0010293)3.83276556
6Impulsivity (HP:0100710)3.67551648
7Absent/shortened dynein arms (HP:0200106)3.65730778
8Dynein arm defect of respiratory motile cilia (HP:0012255)3.65730778
9Ectopic kidney (HP:0000086)3.39566666
10Birth length less than 3rd percentile (HP:0003561)3.32054897
11Supernumerary spleens (HP:0009799)3.27156528
12Meckel diverticulum (HP:0002245)3.24141102
13Abnormality of the preputium (HP:0100587)3.17544218
14Absent radius (HP:0003974)3.13086424
15Abnormal respiratory motile cilium morphology (HP:0005938)3.12435490
16Abnormal respiratory epithelium morphology (HP:0012253)3.12435490
17Abnormality of the ileum (HP:0001549)3.07064307
18Abnormality of the anterior horn cell (HP:0006802)3.01594770
19Degeneration of anterior horn cells (HP:0002398)3.01594770
20Absent forearm bone (HP:0003953)2.95232114
21Aplasia involving forearm bones (HP:0009822)2.95232114
22Abnormality of chromosome stability (HP:0003220)2.94001202
23Duplicated collecting system (HP:0000081)2.89944195
24Hyperglycinemia (HP:0002154)2.87870020
25Absent thumb (HP:0009777)2.71529440
26Abnormal respiratory motile cilium physiology (HP:0012261)2.70684726
27Septo-optic dysplasia (HP:0100842)2.69723466
28Nephroblastoma (Wilms tumor) (HP:0002667)2.64736523
29Breast hypoplasia (HP:0003187)2.63912829
30Abnormality of the renal collecting system (HP:0004742)2.63440957
31Abnormality of serum amino acid levels (HP:0003112)2.62839283
32Rectovaginal fistula (HP:0000143)2.57670896
33Rectal fistula (HP:0100590)2.57670896
34Abnormal lung lobation (HP:0002101)2.55653283
35Bifid tongue (HP:0010297)2.54422640
36Multiple enchondromatosis (HP:0005701)2.51700916
37Rhabdomyosarcoma (HP:0002859)2.50196246
38Medulloblastoma (HP:0002885)2.46091308
39Embryonal renal neoplasm (HP:0011794)2.45695489
40Small intestinal stenosis (HP:0012848)2.44515951
41Duodenal stenosis (HP:0100867)2.44515951
42Abnormal ciliary motility (HP:0012262)2.43900267
43Aplasia/Hypoplasia of the patella (HP:0006498)2.42843856
44Abnormality of serine family amino acid metabolism (HP:0010894)2.42721334
45Abnormality of glycine metabolism (HP:0010895)2.42721334
46Acute encephalopathy (HP:0006846)2.42398579
47Bilateral microphthalmos (HP:0007633)2.37933443
48Short middle phalanx of the 5th finger (HP:0004220)2.37598138
49Intestinal atresia (HP:0011100)2.37192876
50Abnormality of aspartate family amino acid metabolism (HP:0010899)2.36232379
51Triphalangeal thumb (HP:0001199)2.33303619
52Abnormal hair whorl (HP:0010721)2.32322167
53Agnosia (HP:0010524)2.31672218
54Acute necrotizing encephalopathy (HP:0006965)2.31315119
55Chronic bronchitis (HP:0004469)2.29756918
56Patellar aplasia (HP:0006443)2.29696163
57Intestinal fistula (HP:0100819)2.29592973
58Methylmalonic acidemia (HP:0002912)2.29544179
59Short thumb (HP:0009778)2.28299527
60Pancreatic islet-cell hyperplasia (HP:0004510)2.28077490
61Abdominal situs inversus (HP:0003363)2.27044489
62Abnormality of abdominal situs (HP:0011620)2.27044489
63Horseshoe kidney (HP:0000085)2.26652757
64Reticulocytopenia (HP:0001896)2.24873495
65Hyperglycinuria (HP:0003108)2.24709241
66Abnormality of methionine metabolism (HP:0010901)2.23003289
67Abnormality of the duodenum (HP:0002246)2.22954100
68Abnormality of the nasal septum (HP:0000419)2.22922032
69Abnormality of the labia minora (HP:0012880)2.22598619
70Nephronophthisis (HP:0000090)2.19631875
71Osteomalacia (HP:0002749)2.15819507
72Neoplasm of the adrenal gland (HP:0100631)2.15574295
73Abnormality of DNA repair (HP:0003254)2.15381191
74Clubbing of toes (HP:0100760)2.15357150
75Colon cancer (HP:0003003)2.12665143
76Facial cleft (HP:0002006)2.12612749
77Anophthalmia (HP:0000528)2.11547791
78Abnormality of the carotid arteries (HP:0005344)2.11346618
79Aplasia/hypoplasia of the humerus (HP:0006507)2.10633273
80Glioma (HP:0009733)2.08759146
81Sloping forehead (HP:0000340)2.06196403
82Pancreatic cysts (HP:0001737)2.05961955
83Methylmalonic aciduria (HP:0012120)2.05015048
84Aplasia/Hypoplasia of the sacrum (HP:0008517)2.04148608
85Neoplasm of the adrenal cortex (HP:0100641)2.01648154
86Rhinitis (HP:0012384)2.01368639
87Hemivertebrae (HP:0002937)2.01049206
88Tubular atrophy (HP:0000092)2.00148884
89Shawl scrotum (HP:0000049)1.98958236
90Hypoplastic female external genitalia (HP:0012815)1.98698418
91Anal stenosis (HP:0002025)1.98396564
92Duplication of thumb phalanx (HP:0009942)1.98300486
93Neoplasm of the colon (HP:0100273)1.98124489
94Aplasia/Hypoplasia of the sternum (HP:0006714)1.97902986
95Synostosis of carpal bones (HP:0005048)1.97293553
96Short humerus (HP:0005792)1.95913189
97Gonadotropin excess (HP:0000837)1.95448123
98Stenosis of the external auditory canal (HP:0000402)1.95377136
99Hypoplastic labia majora (HP:0000059)1.95265899
100Breast aplasia (HP:0100783)1.94961551
101Spastic diplegia (HP:0001264)1.93919019
102Carpal bone hypoplasia (HP:0001498)1.93764409
103Vaginal fistula (HP:0004320)1.93075324
104Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.92955118
105Missing ribs (HP:0000921)1.92871690
106Ependymoma (HP:0002888)1.91314289
107Cortical dysplasia (HP:0002539)1.90974152
108Abnormal mitochondria in muscle tissue (HP:0008316)1.88462823
109Median cleft lip (HP:0000161)1.88051591
110Optic nerve hypoplasia (HP:0000609)1.87979664
111Abnormality of the renal medulla (HP:0100957)1.87454371
112Selective tooth agenesis (HP:0001592)1.87168766
113Increased CSF lactate (HP:0002490)1.87048832
114Esophageal atresia (HP:0002032)1.86432295
115Increased hepatocellular lipid droplets (HP:0006565)1.86022013
116Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.84242734
117Abnormal number of incisors (HP:0011064)1.84125787
118Bone marrow hypocellularity (HP:0005528)1.83763490
119Tracheoesophageal fistula (HP:0002575)1.83052123
120Oral leukoplakia (HP:0002745)1.82859213
121Labial hypoplasia (HP:0000066)1.82750465
122Preaxial hand polydactyly (HP:0001177)1.82502563
123Myelodysplasia (HP:0002863)1.82158379
124Supernumerary ribs (HP:0005815)1.81727300
125Aplasia/Hypoplasia of the breasts (HP:0010311)1.80433990
126Progressive macrocephaly (HP:0004481)1.80228863
127Absent eyebrow (HP:0002223)1.79576392
128Volvulus (HP:0002580)1.79184422
129Abnormal spermatogenesis (HP:0008669)1.78995958
130Absent septum pellucidum (HP:0001331)1.78634224
131Supernumerary bones of the axial skeleton (HP:0009144)1.78530379
132Abnormality of the labia majora (HP:0012881)1.78339454
133Abnormality of the septum pellucidum (HP:0007375)1.77385438
134Dandy-Walker malformation (HP:0001305)1.77108967
135Long eyelashes (HP:0000527)1.77093187
136Cerebral edema (HP:0002181)1.76416522
137Abnormality of the clitoris (HP:0000056)1.75787609
138Maternal diabetes (HP:0009800)1.75335223
139Mitochondrial inheritance (HP:0001427)1.74793329
140Abnormality of pyrimidine metabolism (HP:0004353)1.74755045
141Homocystinuria (HP:0002156)1.72458420
142Abnormality of homocysteine metabolism (HP:0010919)1.72458420
143Cellular immunodeficiency (HP:0005374)1.71311165
144Hypoplastic pelvis (HP:0008839)1.70328665
145Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.69304760
146Abnormality of alanine metabolism (HP:0010916)1.69304760
147Hyperalaninemia (HP:0003348)1.69304760
148Hypoplasia of the pons (HP:0012110)1.68784299
149Abolished electroretinogram (ERG) (HP:0000550)1.68126941
150Pendular nystagmus (HP:0012043)1.67713533
151Gastrointestinal atresia (HP:0002589)1.67243481
152Cleft eyelid (HP:0000625)1.66628293
153Abnormality of the astrocytes (HP:0100707)1.66570188

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK44.74475760
2CDC73.90442316
3ICK3.17989426
4MKNK12.98523364
5TNIK2.96476324
6MKNK22.88142632
7VRK22.85218890
8SRPK12.84995749
9TTK2.73191307
10TRIM282.71099427
11NEK22.62494259
12STK38L2.57998508
13BUB12.39859724
14CDK122.37784462
15ZAK2.33280394
16NUAK12.26537594
17WEE12.20959415
18PNCK2.18991065
19TAF12.12357737
20EIF2AK22.07572647
21LATS12.01534080
22BRD41.97987274
23MST41.94946954
24EPHA21.94471717
25PLK11.91880291
26BMPR1B1.85292124
27LATS21.84452025
28PLK31.82919709
29CHEK21.79926150
30BRAF1.72860346
31NEK11.67089265
32PASK1.62892762
33STK161.61710130
34NME11.51548880
35TLK11.49191455
36AKT31.48659703
37AURKA1.40074553
38ATR1.39913940
39CDK71.38766089
40AURKB1.35109392
41CHEK11.31373812
42TSSK61.20677813
43CDK191.17935663
44MAP4K21.12821928
45MAP2K31.12718370
46VRK11.09999353
47EIF2AK11.08709538
48ARAF1.08379358
49ATM1.05764155
50BRSK21.04476116
51TGFBR11.01003005
52TAOK21.00067319
53ALK0.97444834
54PRKD30.95554714
55MAP3K30.92701427
56PLK20.89716811
57ERBB40.87850792
58TIE10.86484896
59CSNK1G10.85971544
60PBK0.85550278
61PDK30.84988975
62PDK40.84988975
63EPHA40.84360696
64STK30.84323276
65OXSR10.82660396
66DYRK30.81450765
67CDK20.79853804
68MELK0.79738429
69ACVR1B0.78362244
70CDK40.78340665
71BMPR20.77225008
72MAP3K80.71763635
73CDK30.70774687
74NLK0.70153884
75EPHB20.67045022
76CDK10.66899589
77NEK60.66558446
78MAP3K40.66265772
79BCKDK0.65439503
80STK40.65351242
81EIF2AK30.64684193
82RPS6KB20.64464255
83ADRBK20.64163794
84CSNK1G20.63566344
85FGFR20.63193266
86PIM10.60730568
87PRKCI0.60436020
88YES10.60237549
89CSNK1G30.56780611
90PDK20.55625937
91GRK10.55312808
92CSNK1E0.54631893
93DYRK20.54178093
94CSNK2A10.53466992
95IRAK30.53454891
96FLT30.53102947
97CASK0.52523743
98STK380.51090603
99PRKCG0.50962328
100WNK30.50548674
101CSNK2A20.49994100
102MAP3K110.47948849
103DAPK10.46540307
104RPS6KA50.44133408
105TAOK10.42624030
106BCR0.41825557
107ERBB30.41552519
108INSRR0.41135118
109CSNK1A1L0.41031753
110RPS6KA40.40584311
111IRAK40.38533937
112FRK0.37829132
113MINK10.37202512
114MTOR0.36870940
115AKT10.36626046
116MAPK140.36467815
117CDK80.36464342
118CDK60.36040831
119TESK10.35671887
120MAP3K100.35471446
121PRKDC0.34686450
122CDK90.33395111
123STK240.32116771
124CSNK1D0.28784120
125PAK10.28472721
126BRSK10.28143726
127PIM20.28095729
128GSK3B0.27598787
129MAP3K50.27479042
130MARK20.27442467
131MAP2K60.27062815
132RPS6KB10.26986572
133STK100.26496096
134AKT20.26373828
135KDR0.26319717
136PAK40.24131676
137CSNK1A10.23289779
138FGFR10.22990163
139PRKCE0.22117232
140STK390.20042759
141CLK10.19986295

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.99024811
2DNA replication_Homo sapiens_hsa030303.95112059
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.84195448
4Fanconi anemia pathway_Homo sapiens_hsa034603.71397911
5Homologous recombination_Homo sapiens_hsa034403.52891922
6RNA polymerase_Homo sapiens_hsa030203.32128281
7Basal transcription factors_Homo sapiens_hsa030223.17209429
8RNA transport_Homo sapiens_hsa030133.13618737
9Spliceosome_Homo sapiens_hsa030402.80912441
10Cell cycle_Homo sapiens_hsa041102.71717512
11One carbon pool by folate_Homo sapiens_hsa006702.66852211
12Base excision repair_Homo sapiens_hsa034102.65393691
13Nucleotide excision repair_Homo sapiens_hsa034202.64092942
14Non-homologous end-joining_Homo sapiens_hsa034502.60482109
15mRNA surveillance pathway_Homo sapiens_hsa030152.50036426
16RNA degradation_Homo sapiens_hsa030182.42969667
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.28862870
18Pyrimidine metabolism_Homo sapiens_hsa002402.17240679
19Proteasome_Homo sapiens_hsa030501.96847267
20Propanoate metabolism_Homo sapiens_hsa006401.84643287
21Protein export_Homo sapiens_hsa030601.83079591
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.74654926
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.69050025
24Pyruvate metabolism_Homo sapiens_hsa006201.57130202
25Parkinsons disease_Homo sapiens_hsa050121.55541490
26Ribosome_Homo sapiens_hsa030101.55446668
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.53671386
28Oxidative phosphorylation_Homo sapiens_hsa001901.53138016
29Basal cell carcinoma_Homo sapiens_hsa052171.50623385
30p53 signaling pathway_Homo sapiens_hsa041151.48920543
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.48739145
32Purine metabolism_Homo sapiens_hsa002301.47172257
33Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.41345057
34Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.32364596
35Vitamin B6 metabolism_Homo sapiens_hsa007501.30794406
36Systemic lupus erythematosus_Homo sapiens_hsa053221.30179253
37Fatty acid elongation_Homo sapiens_hsa000621.27487957
38Oocyte meiosis_Homo sapiens_hsa041141.25911742
39Linoleic acid metabolism_Homo sapiens_hsa005911.20844216
40Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.12600310
41Selenocompound metabolism_Homo sapiens_hsa004501.10327334
42Hedgehog signaling pathway_Homo sapiens_hsa043401.04964661
43Carbon metabolism_Homo sapiens_hsa012001.02363899
44Hippo signaling pathway_Homo sapiens_hsa043901.02096737
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.01117939
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.99581780
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.95320628
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.93939865
49Cysteine and methionine metabolism_Homo sapiens_hsa002700.92652070
50Epstein-Barr virus infection_Homo sapiens_hsa051690.86418762
51Herpes simplex infection_Homo sapiens_hsa051680.85338726
52MicroRNAs in cancer_Homo sapiens_hsa052060.83706511
53Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.83100665
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81091488
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.80633969
56Pentose and glucuronate interconversions_Homo sapiens_hsa000400.79881990
57TGF-beta signaling pathway_Homo sapiens_hsa043500.78392882
58Arachidonic acid metabolism_Homo sapiens_hsa005900.78049323
59Alzheimers disease_Homo sapiens_hsa050100.75265988
60Phototransduction_Homo sapiens_hsa047440.72570894
61Wnt signaling pathway_Homo sapiens_hsa043100.72465754
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68143560
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.67480761
64Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.63371498
65Fatty acid degradation_Homo sapiens_hsa000710.61910745
66Notch signaling pathway_Homo sapiens_hsa043300.59944081
67Vitamin digestion and absorption_Homo sapiens_hsa049770.59744060
68Tryptophan metabolism_Homo sapiens_hsa003800.59192871
69Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59047033
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58488286
71beta-Alanine metabolism_Homo sapiens_hsa004100.57821105
72Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56913959
73Ether lipid metabolism_Homo sapiens_hsa005650.56754195
74Fat digestion and absorption_Homo sapiens_hsa049750.56328439
75Butanoate metabolism_Homo sapiens_hsa006500.56182220
76Peroxisome_Homo sapiens_hsa041460.56074407
77Folate biosynthesis_Homo sapiens_hsa007900.54248049
78Caffeine metabolism_Homo sapiens_hsa002320.53954542
79Viral carcinogenesis_Homo sapiens_hsa052030.53946427
80Adherens junction_Homo sapiens_hsa045200.53591408
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53467820
82Fatty acid metabolism_Homo sapiens_hsa012120.53261826
83HTLV-I infection_Homo sapiens_hsa051660.50223084
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49700037
85Steroid biosynthesis_Homo sapiens_hsa001000.49406715
86Retinol metabolism_Homo sapiens_hsa008300.48791362
87Nitrogen metabolism_Homo sapiens_hsa009100.48253460
88Sphingolipid metabolism_Homo sapiens_hsa006000.45049316
89Huntingtons disease_Homo sapiens_hsa050160.43687361
90Maturity onset diabetes of the young_Homo sapiens_hsa049500.43466132
91Thyroid cancer_Homo sapiens_hsa052160.43201750
92Lysine degradation_Homo sapiens_hsa003100.42805188
93Alcoholism_Homo sapiens_hsa050340.42753808
94Glutathione metabolism_Homo sapiens_hsa004800.42457385
95Drug metabolism - other enzymes_Homo sapiens_hsa009830.39552245
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39253372
97Autoimmune thyroid disease_Homo sapiens_hsa053200.38378873
98Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.37982952
99Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37417901
100Tyrosine metabolism_Homo sapiens_hsa003500.36959894
101Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35175505
102Sulfur relay system_Homo sapiens_hsa041220.34669312
103Phenylalanine metabolism_Homo sapiens_hsa003600.33808922
104Tight junction_Homo sapiens_hsa045300.33554326
105Cardiac muscle contraction_Homo sapiens_hsa042600.32296763
106NOD-like receptor signaling pathway_Homo sapiens_hsa046210.31817863
107Arginine and proline metabolism_Homo sapiens_hsa003300.31088621
108Steroid hormone biosynthesis_Homo sapiens_hsa001400.30280311
109Prostate cancer_Homo sapiens_hsa052150.30258804
110Pathways in cancer_Homo sapiens_hsa052000.30007969
111Primary bile acid biosynthesis_Homo sapiens_hsa001200.29363914
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.27607908
113Nicotine addiction_Homo sapiens_hsa050330.27517610
114Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.27411633
115Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.26264073
116Glucagon signaling pathway_Homo sapiens_hsa049220.26091985
117Cyanoamino acid metabolism_Homo sapiens_hsa004600.25371512
118Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.24779613
119NF-kappa B signaling pathway_Homo sapiens_hsa040640.24770469
120N-Glycan biosynthesis_Homo sapiens_hsa005100.24046274
121Pentose phosphate pathway_Homo sapiens_hsa000300.23866875
122Metabolic pathways_Homo sapiens_hsa011000.23575840
123Melanoma_Homo sapiens_hsa052180.22345046
124Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.22247646
125Antigen processing and presentation_Homo sapiens_hsa046120.21995016
126Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.21109192
127Graft-versus-host disease_Homo sapiens_hsa053320.18450799
128Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.17897549
129Small cell lung cancer_Homo sapiens_hsa052220.17701792
130Ovarian steroidogenesis_Homo sapiens_hsa049130.16841897
131Allograft rejection_Homo sapiens_hsa053300.16338996
132Biosynthesis of amino acids_Homo sapiens_hsa012300.14107545
133Glycerophospholipid metabolism_Homo sapiens_hsa005640.13977457
134Melanogenesis_Homo sapiens_hsa049160.13080833
135Asthma_Homo sapiens_hsa053100.11684015
136Chemical carcinogenesis_Homo sapiens_hsa052040.09758713
137Colorectal cancer_Homo sapiens_hsa052100.08365981
138Influenza A_Homo sapiens_hsa051640.08274956

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