NR2C2AP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.16775081
2viral transcription (GO:0019083)5.25261573
3maturation of SSU-rRNA (GO:0030490)5.16481614
4ribosomal small subunit assembly (GO:0000028)5.12701264
5translational termination (GO:0006415)5.11955464
6ribosomal small subunit biogenesis (GO:0042274)4.90677154
7proteasome assembly (GO:0043248)4.90059219
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.64852817
9translational elongation (GO:0006414)4.62448914
10cotranslational protein targeting to membrane (GO:0006613)4.57077379
11protein targeting to ER (GO:0045047)4.53557305
12formation of translation preinitiation complex (GO:0001731)4.53404390
13translational initiation (GO:0006413)4.52109295
14ribosomal large subunit biogenesis (GO:0042273)4.46779469
15nucleobase biosynthetic process (GO:0046112)4.45671454
16purine nucleobase biosynthetic process (GO:0009113)4.44863025
17energy coupled proton transport, down electrochemical gradient (GO:0015985)4.35288670
18ATP synthesis coupled proton transport (GO:0015986)4.35288670
19protein localization to endoplasmic reticulum (GO:0070972)4.31901115
20establishment of protein localization to endoplasmic reticulum (GO:0072599)4.29591001
21ribonucleoprotein complex biogenesis (GO:0022613)4.15739002
22negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.14067413
23pseudouridine synthesis (GO:0001522)4.11069029
24termination of RNA polymerase III transcription (GO:0006386)4.09261653
25transcription elongation from RNA polymerase III promoter (GO:0006385)4.09261653
26viral life cycle (GO:0019058)4.08418056
27cellular protein complex disassembly (GO:0043624)4.07780334
28DNA strand elongation involved in DNA replication (GO:0006271)4.02724303
29nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.01172088
30translation (GO:0006412)3.97478883
31positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.86637351
32pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.86630997
33telomere maintenance via semi-conservative replication (GO:0032201)3.84570588
34DNA strand elongation (GO:0022616)3.82160512
35ribosome biogenesis (GO:0042254)3.81728542
36negative regulation of ligase activity (GO:0051352)3.81550957
37negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.81550957
38regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.79958458
39anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.79072696
40rRNA processing (GO:0006364)3.78648715
41GDP-mannose metabolic process (GO:0019673)3.77827712
42L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.66393819
43rRNA metabolic process (GO:0016072)3.65514055
44regulation of cellular amino acid metabolic process (GO:0006521)3.64902258
45deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.60846219
46rRNA modification (GO:0000154)3.60496031
47DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.58876077
48DNA replication initiation (GO:0006270)3.54811427
49ribosome assembly (GO:0042255)3.53132036
50protein complex disassembly (GO:0043241)3.52879260
51antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.52724817
52intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.51884681
53signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.51884681
54signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.51602313
55signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.51602313
56signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.51602313
57cellular component biogenesis (GO:0044085)3.49774821
58respiratory electron transport chain (GO:0022904)3.47275831
59signal transduction involved in DNA damage checkpoint (GO:0072422)3.45030762
60signal transduction involved in DNA integrity checkpoint (GO:0072401)3.45030762
61spliceosomal snRNP assembly (GO:0000387)3.43910544
627-methylguanosine mRNA capping (GO:0006370)3.43521332
63DNA replication checkpoint (GO:0000076)3.40825640
64signal transduction involved in cell cycle checkpoint (GO:0072395)3.40053098
65electron transport chain (GO:0022900)3.40014665
66positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.39170780
67mitochondrial respiratory chain complex assembly (GO:0033108)3.39068576
687-methylguanosine RNA capping (GO:0009452)3.37612971
69RNA capping (GO:0036260)3.37612971
70protein localization to mitochondrion (GO:0070585)3.37542362
71rRNA methylation (GO:0031167)3.37433522
72macromolecular complex disassembly (GO:0032984)3.36854098
73base-excision repair, AP site formation (GO:0006285)3.35819130
74establishment of viral latency (GO:0019043)3.35734410
75regulation of mitochondrial translation (GO:0070129)3.35627392
76guanosine-containing compound biosynthetic process (GO:1901070)3.33437335
77protein maturation by protein folding (GO:0022417)3.30388267
78pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.29149996
79antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.28986735
80telomere maintenance via recombination (GO:0000722)3.28693689
81transcription from RNA polymerase I promoter (GO:0006360)3.28129466
82positive regulation of ligase activity (GO:0051351)3.28044826
83protein complex biogenesis (GO:0070271)3.25313825
84protein deneddylation (GO:0000338)3.23657070
85cullin deneddylation (GO:0010388)3.22446226
86mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.20002492
87peptidyl-histidine modification (GO:0018202)3.18496231
88establishment of protein localization to mitochondrial membrane (GO:0090151)3.18029380
89mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.17507717
90termination of RNA polymerase I transcription (GO:0006363)3.14686395
91pyrimidine nucleotide catabolic process (GO:0006244)3.14550359
92transcription-coupled nucleotide-excision repair (GO:0006283)3.13917586
93mitotic metaphase plate congression (GO:0007080)3.13053942
94nuclear-transcribed mRNA catabolic process (GO:0000956)3.12867778
95L-methionine salvage (GO:0071267)3.12782408
96L-methionine biosynthetic process (GO:0071265)3.12782408
97amino acid salvage (GO:0043102)3.12782408
98RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.11279295
99tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.11279295
100transcription from mitochondrial promoter (GO:0006390)3.10317207
101transcription elongation from RNA polymerase I promoter (GO:0006362)3.10262410
102oxidative phosphorylation (GO:0006119)3.10004977
103protein targeting to mitochondrion (GO:0006626)3.06179434
104mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.06075508
105mitochondrial respiratory chain complex I assembly (GO:0032981)3.06075508
106NADH dehydrogenase complex assembly (GO:0010257)3.06075508
107CENP-A containing nucleosome assembly (GO:0034080)3.05550445
108establishment of integrated proviral latency (GO:0075713)3.05513417
109folic acid-containing compound biosynthetic process (GO:0009396)3.05437713
110chromatin remodeling at centromere (GO:0031055)3.05337916
111G1/S transition of mitotic cell cycle (GO:0000082)3.04902371
112cell cycle G1/S phase transition (GO:0044843)3.04902371
113regulation of translational termination (GO:0006449)3.04467646
114nucleotide-excision repair, DNA gap filling (GO:0006297)3.03761817
115establishment of protein localization to mitochondrion (GO:0072655)3.03636300
116UTP biosynthetic process (GO:0006228)3.02094689
117regulation of ubiquitin-protein transferase activity (GO:0051438)3.01664446
118exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.01119199
119folic acid metabolic process (GO:0046655)3.00748131
120telomere maintenance via telomere lengthening (GO:0010833)3.00391603
121cytochrome complex assembly (GO:0017004)3.00046189
122GTP biosynthetic process (GO:0006183)2.97685654
123nucleobase-containing small molecule interconversion (GO:0015949)2.97659940
124chaperone-mediated protein transport (GO:0072321)2.97057863
125protein targeting to membrane (GO:0006612)2.96583749
126DNA unwinding involved in DNA replication (GO:0006268)2.95726902
127mRNA catabolic process (GO:0006402)2.95563609
128mitotic recombination (GO:0006312)2.95079402
129regulation of ligase activity (GO:0051340)2.93987048

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.05730864
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.28319107
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.01259225
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.82601830
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.56174958
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.52269314
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.38323979
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.34318719
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.33532046
10MYC_18358816_ChIP-ChIP_MESCs_Mouse3.12224452
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.05702216
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.93360443
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.90966612
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.77995989
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.77243349
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.57498088
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.50870414
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.47500566
19VDR_23849224_ChIP-Seq_CD4+_Human2.47454053
20XRN2_22483619_ChIP-Seq_HELA_Human2.44016574
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.31560379
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.23879860
23E2F1_18555785_ChIP-Seq_MESCs_Mouse2.21774643
24E2F4_17652178_ChIP-ChIP_JURKAT_Human2.21325405
25DCP1A_22483619_ChIP-Seq_HELA_Human2.20471909
26NELFA_20434984_ChIP-Seq_ESCs_Mouse2.13371671
27GABP_19822575_ChIP-Seq_HepG2_Human2.03776216
28THAP11_20581084_ChIP-Seq_MESCs_Mouse2.03210722
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.02814253
30FOXP3_21729870_ChIP-Seq_TREG_Human2.01204798
31YY1_21170310_ChIP-Seq_MESCs_Mouse1.97711226
32SRF_21415370_ChIP-Seq_HL-1_Mouse1.91574585
33CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.90115175
34TTF2_22483619_ChIP-Seq_HELA_Human1.87153717
35FOXM1_23109430_ChIP-Seq_U2OS_Human1.76648060
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.76132859
37TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.70434735
38PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.68514837
39FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.68218711
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.61018229
41MYCN_18555785_ChIP-Seq_MESCs_Mouse1.60451033
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.57002887
43ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.56772432
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.55055271
45MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.54263736
46MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.52273612
47CIITA_25753668_ChIP-Seq_RAJI_Human1.48384494
48ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47528920
49AR_21909140_ChIP-Seq_LNCAP_Human1.44794320
50ELK1_19687146_ChIP-ChIP_HELA_Human1.44478723
51* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.43528131
52* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.37831105
53* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.37446449
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36769933
55SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.35296815
56PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.34852026
57POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.33516300
58KDM5A_27292631_Chip-Seq_BREAST_Human1.29873982
59CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29827990
60STAT3_1855785_ChIP-Seq_MESCs_Mouse1.29300771
61E2F1_21310950_ChIP-Seq_MCF-7_Human1.24142995
62KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.22703571
63MYC_22102868_ChIP-Seq_BL_Human1.20685994
64YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19607170
65NOTCH1_21737748_ChIP-Seq_TLL_Human1.18929868
66ELK1_22589737_ChIP-Seq_MCF10A_Human1.17674573
67MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.17370740
68KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16988396
69SPI1_23547873_ChIP-Seq_NB4_Human1.14764634
70POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14492389
71BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.13192315
72TET1_21451524_ChIP-Seq_MESCs_Mouse1.09907381
73SRY_22984422_ChIP-ChIP_TESTIS_Rat1.09564310
74VDR_21846776_ChIP-Seq_THP-1_Human1.08042813
75TFEB_21752829_ChIP-Seq_HELA_Human1.05826023
76KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05702179
77DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04269919
78DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.03303898
79SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.02013877
80MYC_18940864_ChIP-ChIP_HL60_Human1.01890576
81* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00459745
82CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.99447488
83TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.99059315
84HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.97467487
85SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.96983086
86CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.96643914
87ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96586446
88E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.96442886
89CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.96054754
90GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.94230875
91CTCF_18555785_ChIP-Seq_MESCs_Mouse0.94083364
92OCT4_18692474_ChIP-Seq_MEFs_Mouse0.93426969
93ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.92605060
94IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.92042784
95* P68_20966046_ChIP-Seq_HELA_Human0.91185379
96SOX2_18692474_ChIP-Seq_MEFs_Mouse0.89969455
97CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.89396348
98TBX5_21415370_ChIP-Seq_HL-1_Mouse0.89284719
99FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88768476
100HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.87484835
101RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.87112565
102TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86263038
103BCL6_27268052_Chip-Seq_Bcells_Human0.86051957
104YY1_22570637_ChIP-Seq_MALME-3M_Human0.85900887
105MAF_26560356_Chip-Seq_TH2_Human0.84929178
106ELF1_20517297_ChIP-Seq_JURKAT_Human0.84343739
107CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.83349634
108SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.83170332
109EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.81568878
110ZNF263_19887448_ChIP-Seq_K562_Human0.81367137
111FOXP1_21924763_ChIP-Seq_HESCs_Human0.80278993
112PADI4_21655091_ChIP-ChIP_MCF-7_Human0.80113156
113CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.78880940

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.35365599
2MP0004957_abnormal_blastocyst_morpholog4.54704578
3MP0003111_abnormal_nucleus_morphology3.69283039
4MP0003077_abnormal_cell_cycle3.40040884
5MP0010094_abnormal_chromosome_stability3.27745039
6MP0008057_abnormal_DNA_replication3.26956105
7MP0003806_abnormal_nucleotide_metabolis2.99597066
8MP0008058_abnormal_DNA_repair2.87407385
9MP0008932_abnormal_embryonic_tissue2.73130136
10MP0003718_maternal_effect2.53195016
11MP0002396_abnormal_hematopoietic_system2.36158723
12MP0003186_abnormal_redox_activity2.19775518
13MP0009333_abnormal_splenocyte_physiolog2.10018457
14MP0008007_abnormal_cellular_replicative2.08354633
15MP0000490_abnormal_crypts_of2.01992756
16MP0009379_abnormal_foot_pigmentation2.01216143
17MP0001730_embryonic_growth_arrest1.91081884
18MP0006036_abnormal_mitochondrial_physio1.90738868
19MP0010234_abnormal_vibrissa_follicle1.89404632
20MP0003786_premature_aging1.84878342
21MP0001986_abnormal_taste_sensitivity1.78106268
22MP0009840_abnormal_foam_cell1.73592137
23MP0006035_abnormal_mitochondrial_morpho1.72228525
24MP0003763_abnormal_thymus_physiology1.70123330
25MP0000350_abnormal_cell_proliferation1.66885976
26MP0008260_abnormal_autophagy1.65526896
27MP0005501_abnormal_skin_physiology1.63692942
28MP0002019_abnormal_tumor_incidence1.54939714
29MP0000358_abnormal_cell_content/1.53666585
30MP0002132_abnormal_respiratory_system1.50890082
31MP0003656_abnormal_erythrocyte_physiolo1.49291448
32MP0005075_abnormal_melanosome_morpholog1.43067561
33MP0005671_abnormal_response_to1.39507865
34MP0000313_abnormal_cell_death1.38950711
35MP0001853_heart_inflammation1.36767113
36MP0000689_abnormal_spleen_morphology1.36675604
37MP0002398_abnormal_bone_marrow1.36330823
38MP0001835_abnormal_antigen_presentation1.34967306
39MP0002722_abnormal_immune_system1.34617611
40MP0002877_abnormal_melanocyte_morpholog1.32406323
41MP0001545_abnormal_hematopoietic_system1.31843964
42MP0005397_hematopoietic_system_phenotyp1.31843964
43MP0009785_altered_susceptibility_to1.31341986
44MP0002080_prenatal_lethality1.28013242
45MP0003315_abnormal_perineum_morphology1.26644353
46MP0003123_paternal_imprinting1.23603795
47MP0002429_abnormal_blood_cell1.21695936
48MP0001697_abnormal_embryo_size1.21051762
49MP0002796_impaired_skin_barrier1.20063085
50MP0008995_early_reproductive_senescence1.19451412
51MP0010352_gastrointestinal_tract_polyps1.17708354
52MP0001873_stomach_inflammation1.16326617
53MP0000858_altered_metastatic_potential1.16283804
54MP0000716_abnormal_immune_system1.15578347
55MP0002420_abnormal_adaptive_immunity1.13308962
56MP0003221_abnormal_cardiomyocyte_apopto1.13263292
57MP0003866_abnormal_defecation1.12283761
58MP0009697_abnormal_copulation1.12049900
59MP0001819_abnormal_immune_cell1.11713450
60MP0005174_abnormal_tail_pigmentation1.10621927
61MP0002148_abnormal_hypersensitivity_rea1.09884302
62MP0005000_abnormal_immune_tolerance1.07502853
63MP0001800_abnormal_humoral_immune1.07330842
64MP0005025_abnormal_response_to1.06291729
65MP0008875_abnormal_xenobiotic_pharmacok1.06245796
66MP0000703_abnormal_thymus_morphology1.06086633
67MP0004233_abnormal_muscle_weight1.05228487
68MP0002723_abnormal_immune_serum1.05221163
69MP0002938_white_spotting1.03561290
70MP0005380_embryogenesis_phenotype1.02949451
71MP0001672_abnormal_embryogenesis/_devel1.02949451
72MP0005451_abnormal_body_composition1.02524449
73MP0002452_abnormal_antigen_presenting1.00152839
74MP0001881_abnormal_mammary_gland0.97291713
75MP0001764_abnormal_homeostasis0.97282092
76MP0000465_gastrointestinal_hemorrhage0.96856164
77MP0005083_abnormal_biliary_tract0.96355951
78MP0008877_abnormal_DNA_methylation0.96044638
79MP0009278_abnormal_bone_marrow0.95229543
80MP0005058_abnormal_lysosome_morphology0.92884108
81MP0002751_abnormal_autonomic_nervous0.91531411
82MP0005330_cardiomyopathy0.89864025
83MP0002163_abnormal_gland_morphology0.89579768
84MP0006292_abnormal_olfactory_placode0.89492838
85MP0000685_abnormal_immune_system0.87662714
86MP0003984_embryonic_growth_retardation0.86407846
87MP0001905_abnormal_dopamine_level0.84322588
88MP0010307_abnormal_tumor_latency0.83947262
89MP0002160_abnormal_reproductive_system0.83746529
90MP0002088_abnormal_embryonic_growth/wei0.82831961
91MP0002736_abnormal_nociception_after0.82289863
92MP0001929_abnormal_gametogenesis0.81561412
93MP0002210_abnormal_sex_determination0.80810197
94MP0000372_irregular_coat_pigmentation0.80385895
95MP0005384_cellular_phenotype0.79766909
96MP0001145_abnormal_male_reproductive0.79638052
97MP0001727_abnormal_embryo_implantation0.79220964
98MP0003567_abnormal_fetal_cardiomyocyte0.78631613
99MP0005408_hypopigmentation0.78533840
100MP0002085_abnormal_embryonic_tissue0.77982707
101MP0005084_abnormal_gallbladder_morpholo0.77977556
102MP0008873_increased_physiological_sensi0.77518724
103MP0001216_abnormal_epidermal_layer0.77459197
104MP0002405_respiratory_system_inflammati0.77324092
105MP0005389_reproductive_system_phenotype0.76796774
106MP0001529_abnormal_vocalization0.76056927
107MP0004147_increased_porphyrin_level0.75676079
108MP0004808_abnormal_hematopoietic_stem0.75595208
109MP0001542_abnormal_bone_strength0.73624644
110MP0005332_abnormal_amino_acid0.73461035
111MP0000613_abnormal_salivary_gland0.73405570
112MP0002006_tumorigenesis0.72997752
113MP0006082_CNS_inflammation0.72501917
114MP0002277_abnormal_respiratory_mucosa0.72274880
115MP0003436_decreased_susceptibility_to0.71780116
116MP0000750_abnormal_muscle_regeneration0.71705994
117MP0001919_abnormal_reproductive_system0.70692815
118MP0008469_abnormal_protein_level0.70383044
119MP0000015_abnormal_ear_pigmentation0.69775611
120MP0001845_abnormal_inflammatory_respons0.68890629
121MP0000653_abnormal_sex_gland0.68657085
122MP0010155_abnormal_intestine_physiology0.68069800
123MP0002086_abnormal_extraembryonic_tissu0.66845086
124MP0002419_abnormal_innate_immunity0.66578353
125MP0001661_extended_life_span0.66324696
126MP0001346_abnormal_lacrimal_gland0.66187685
127MP0002095_abnormal_skin_pigmentation0.66021944
128MP0002234_abnormal_pharynx_morphology0.64948257
129MP0003136_yellow_coat_color0.64797703
130MP0005266_abnormal_metabolism0.64177461
131MP0005621_abnormal_cell_physiology0.63599678
132MP0005319_abnormal_enzyme/_coenzyme0.63415677
133MP0008789_abnormal_olfactory_epithelium0.58454738
134MP0000627_abnormal_mammary_gland0.58097245

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.51501875
2Abnormal number of erythroid precursors (HP:0012131)5.06880640
3Cerebral hypomyelination (HP:0006808)4.68078795
4Reticulocytopenia (HP:0001896)4.55793777
5Aplastic anemia (HP:0001915)4.34315529
6Oral leukoplakia (HP:0002745)4.00049371
7Birth length less than 3rd percentile (HP:0003561)3.99615949
8Macrocytic anemia (HP:0001972)3.91187847
9Testicular atrophy (HP:0000029)3.78492596
10Breast hypoplasia (HP:0003187)3.73378451
11Decreased activity of mitochondrial respiratory chain (HP:0008972)3.52936138
12Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.52936138
13Rough bone trabeculation (HP:0100670)3.48622913
14Hepatocellular necrosis (HP:0001404)3.44424182
15Pallor (HP:0000980)3.41751489
16Cerebral edema (HP:0002181)3.41061789
173-Methylglutaconic aciduria (HP:0003535)3.27917276
18Mitochondrial inheritance (HP:0001427)3.25612553
19Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.16824160
20Hepatic necrosis (HP:0002605)3.07475660
21Increased CSF lactate (HP:0002490)3.07210630
22Acute necrotizing encephalopathy (HP:0006965)3.06884387
23Increased serum lactate (HP:0002151)3.02077984
24Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.99309693
25Abnormality of glycolysis (HP:0004366)2.86666835
26Increased serum pyruvate (HP:0003542)2.86666835
27Carpal bone hypoplasia (HP:0001498)2.86060298
28Increased hepatocellular lipid droplets (HP:0006565)2.82364541
29Colon cancer (HP:0003003)2.81221999
30Ragged-red muscle fibers (HP:0003200)2.78278046
31Multiple enchondromatosis (HP:0005701)2.74106816
32Abnormal mitochondria in muscle tissue (HP:0008316)2.72557721
33Chromosomal breakage induced by crosslinking agents (HP:0003221)2.68299609
34CNS hypomyelination (HP:0003429)2.66474533
35Premature ovarian failure (HP:0008209)2.64376407
36Degeneration of anterior horn cells (HP:0002398)2.62396924
37Abnormality of the anterior horn cell (HP:0006802)2.62396924
38Pancytopenia (HP:0001876)2.60812333
39Trismus (HP:0000211)2.59807112
40Exertional dyspnea (HP:0002875)2.57820692
41Microretrognathia (HP:0000308)2.57635893
42Sparse eyelashes (HP:0000653)2.57592707
43Lipid accumulation in hepatocytes (HP:0006561)2.55928167
44Secondary amenorrhea (HP:0000869)2.55208474
45Chronic otitis media (HP:0000389)2.52842163
46Poor head control (HP:0002421)2.52267212
47Acute encephalopathy (HP:0006846)2.49529806
48Congenital ichthyosiform erythroderma (HP:0007431)2.46286158
49Type I transferrin isoform profile (HP:0003642)2.45814100
50Abnormal trabecular bone morphology (HP:0100671)2.45128891
51Renal Fanconi syndrome (HP:0001994)2.45017047
52Thrombocytosis (HP:0001894)2.44945414
53Chromsome breakage (HP:0040012)2.42104413
54Premature graying of hair (HP:0002216)2.41194929
55Abnormality of small intestinal villus morphology (HP:0011472)2.41055785
56Villous atrophy (HP:0011473)2.41055785
57Dicarboxylic aciduria (HP:0003215)2.38243900
58Abnormality of dicarboxylic acid metabolism (HP:0010995)2.38243900
59Progressive muscle weakness (HP:0003323)2.32121000
60Lactic acidosis (HP:0003128)2.31514288
61Amniotic constriction ring (HP:0009775)2.30546685
62Abnormality of placental membranes (HP:0011409)2.30546685
63CNS demyelination (HP:0007305)2.29677735
64Aplasia/Hypoplasia of the sacrum (HP:0008517)2.25592986
65Emotional lability (HP:0000712)2.24192025
66Respiratory failure (HP:0002878)2.22807065
67Postnatal microcephaly (HP:0005484)2.22539996
68Abnormality of the umbilical cord (HP:0010881)2.20820237
69Cleft eyelid (HP:0000625)2.19062843
70Hypertensive crisis (HP:0100735)2.18979380
71Respiratory difficulties (HP:0002880)2.16846446
72Meckel diverticulum (HP:0002245)2.15394694
73Exercise intolerance (HP:0003546)2.15320089
74Patellar aplasia (HP:0006443)2.15172449
75Bone marrow hypocellularity (HP:0005528)2.14782266
76Elevated erythrocyte sedimentation rate (HP:0003565)2.14401352
77Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.14075398
78Progressive macrocephaly (HP:0004481)2.14014836
79Abnormality of renal resorption (HP:0011038)2.13619095
80Squamous cell carcinoma (HP:0002860)2.11733340
81Increased intramyocellular lipid droplets (HP:0012240)2.11598229
82Leukodystrophy (HP:0002415)2.11387349
83Progressive microcephaly (HP:0000253)2.10738124
84Microvesicular hepatic steatosis (HP:0001414)2.10387772
85Lethargy (HP:0001254)2.10319191
86Aplasia/Hypoplasia of the patella (HP:0006498)2.08944525
87Petechiae (HP:0000967)2.07969190
88Death in infancy (HP:0001522)2.06826132
89Megaloblastic anemia (HP:0001889)2.05512809
90Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.05383861
91Abnormality of alanine metabolism (HP:0010916)2.05383861
92Hyperalaninemia (HP:0003348)2.05383861
93Abnormality of the ileum (HP:0001549)2.05315930
94IgM deficiency (HP:0002850)2.04372315
95Panhypogammaglobulinemia (HP:0003139)2.02678619
96Delusions (HP:0000746)2.02532054
97Abnormality of the preputium (HP:0100587)2.01695283
98Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.01412228
99Abnormality of the heme biosynthetic pathway (HP:0010472)2.00899180
100Agnosia (HP:0010524)1.99285290
101Hypoplasia of the pons (HP:0012110)1.98693519
102Absent thumb (HP:0009777)1.98615715
103Personality changes (HP:0000751)1.97865106
104Methylmalonic aciduria (HP:0012120)1.97716202
105Muscle fiber atrophy (HP:0100295)1.97427338
106Poikiloderma (HP:0001029)1.97137329
107Optic disc pallor (HP:0000543)1.95944936
108Opisthotonus (HP:0002179)1.95905375
109Neoplasm of the pancreas (HP:0002894)1.93305511
110Generalized aminoaciduria (HP:0002909)1.92796506
111Congenital, generalized hypertrichosis (HP:0004540)1.90182110
112Spastic paraparesis (HP:0002313)1.89341798
113Horseshoe kidney (HP:0000085)1.88918031
114Aplasia/Hypoplasia of the uvula (HP:0010293)1.88390617
115Tongue fasciculations (HP:0001308)1.86669923
116Neoplasm of head and neck (HP:0012288)1.84559028
117Esophageal neoplasm (HP:0100751)1.84559028
118Glossoptosis (HP:0000162)1.82769108
119Cellular immunodeficiency (HP:0005374)1.81630224
120Ureteral duplication (HP:0000073)1.81621401
121Atrophy/Degeneration involving motor neurons (HP:0007373)1.81496672
122Abnormality of the pons (HP:0007361)1.79984661
123Increased muscle lipid content (HP:0009058)1.79416052
124Abnormality of T cell physiology (HP:0011840)1.78256099
125Erythema (HP:0010783)1.77977496
126Abnormal protein glycosylation (HP:0012346)1.77766164
127Abnormal glycosylation (HP:0012345)1.77766164
128Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.77766164
129Abnormal protein N-linked glycosylation (HP:0012347)1.77766164
130Selective tooth agenesis (HP:0001592)1.77579605
131Reduced antithrombin III activity (HP:0001976)1.76738646
132Recurrent cutaneous fungal infections (HP:0011370)1.75773217
133Chronic mucocutaneous candidiasis (HP:0002728)1.75773217
134Hypokinesia (HP:0002375)1.75271129
135Myelodysplasia (HP:0002863)1.74639767
136Abnormality of chromosome stability (HP:0003220)1.74536225
137Hypergonadotropic hypogonadism (HP:0000815)1.71374826
138Hepatosplenomegaly (HP:0001433)1.68200119

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.02581756
2VRK24.89495433
3NME24.61253379
4STK163.82624464
5WEE13.63887895
6TESK23.20635988
7PIM22.84339605
8EIF2AK12.54319050
9VRK12.39121741
10PBK2.29766501
11SMG12.23049570
12TLK12.17282644
13EIF2AK31.93061899
14ACVR1B1.86182340
15TSSK61.80678118
16DYRK31.80139476
17CDC71.79449683
18RPS6KB21.65634393
19MAP4K11.62248811
20MAP3K111.59079017
21SRPK11.56576193
22CCNB11.56386723
23ARAF1.53413381
24PLK41.52229621
25EPHA21.49648279
26NME11.47613350
27IRAK31.47216606
28BRSK21.45135054
29AURKA1.34480014
30NEK21.29081643
31LIMK11.28838317
32PLK11.26685851
33BCKDK1.24416793
34TESK11.22192000
35SCYL21.21777860
36CDK71.19134296
37MAPKAPK31.19030952
38MAP2K21.17615740
39BRAF1.16072150
40TTK1.14783798
41RPS6KA41.13474349
42AURKB1.08664740
43CDK191.07829846
44FLT31.06869921
45NEK11.03505020
46MST1R1.03349552
47MAP3K81.02837121
48DYRK21.01659672
49TAF11.00786700
50MAP3K30.99373643
51ZAP700.98967843
52MAP3K120.96650715
53PLK30.95190745
54KDR0.95084328
55MAP2K30.93310282
56BRSK10.93147394
57KIT0.90935104
58ZAK0.89760534
59NUAK10.89657927
60PAK10.88740423
61NLK0.86576084
62TAOK20.85324842
63ERN10.84967491
64PAK40.84774244
65PASK0.84188288
66CHEK20.83488703
67GRK60.83272806
68PRKCI0.82734171
69PIM10.79893128
70MST40.78961722
71ABL20.78224281
72ICK0.77973832
73STK100.74448061
74CDK80.74011828
75LRRK20.73045124
76ATR0.69184245
77BMPR1B0.67166859
78CSNK2A10.66628128
79CSNK2A20.66499124
80MUSK0.66197345
81IKBKB0.65339939
82TRIM280.62464601
83STK40.61591958
84CSF1R0.61379092
85TGFBR10.61124382
86TEC0.59904731
87EEF2K0.59717310
88PDK20.58784753
89RPS6KA50.57059632
90CSNK1G30.56943540
91MATK0.56232091
92MKNK10.55239788
93ILK0.55037826
94MAPK110.54610868
95BTK0.54564913
96TRIB30.53698634
97BLK0.53341088
98CLK10.53137033
99MAP2K60.52852505
100SYK0.52815042
101CSNK1A1L0.52530470
102MAPKAPK50.52394395
103IKBKE0.51437830
104WNK40.51326990
105SIK30.51063313
106CDK90.50026881
107TBK10.48598529
108CHEK10.47092135
109DAPK30.46677484
110MAPK40.45516378
111CSNK1G10.44930495
112GRK50.44174279
113TAOK10.42019810
114DAPK10.41348323
115CDK40.40414483
116LYN0.40119361
117EIF2AK20.38380646
118MAPK150.38227493
119TXK0.34621348
120ATM0.33712775
121YES10.32315695
122CDK20.32232157
123RAF10.32028011
124ADRBK20.31435463
125MKNK20.30128320
126MAP3K50.29270602
127IRAK20.28639126
128ALK0.28039293

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.01349833
2Proteasome_Homo sapiens_hsa030504.63220338
3DNA replication_Homo sapiens_hsa030304.06079834
4RNA polymerase_Homo sapiens_hsa030203.87087069
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.34036593
6Mismatch repair_Homo sapiens_hsa034303.26699084
7Base excision repair_Homo sapiens_hsa034102.88306405
8Pyrimidine metabolism_Homo sapiens_hsa002402.76043682
9Spliceosome_Homo sapiens_hsa030402.68385849
10RNA transport_Homo sapiens_hsa030132.45547640
11Nucleotide excision repair_Homo sapiens_hsa034202.29917868
12Homologous recombination_Homo sapiens_hsa034402.29461799
13Oxidative phosphorylation_Homo sapiens_hsa001902.00669054
14Protein export_Homo sapiens_hsa030601.99582274
15Parkinsons disease_Homo sapiens_hsa050121.93652181
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.88579562
17Folate biosynthesis_Homo sapiens_hsa007901.80840857
18One carbon pool by folate_Homo sapiens_hsa006701.80655422
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.76678644
20Vitamin B6 metabolism_Homo sapiens_hsa007501.73408286
21Cell cycle_Homo sapiens_hsa041101.60961477
22Basal transcription factors_Homo sapiens_hsa030221.48833782
23Huntingtons disease_Homo sapiens_hsa050161.48546573
24Purine metabolism_Homo sapiens_hsa002301.45136813
25RNA degradation_Homo sapiens_hsa030181.41375392
26Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.39810279
27Sulfur relay system_Homo sapiens_hsa041221.38669379
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.33607554
29Fanconi anemia pathway_Homo sapiens_hsa034601.24528652
30Non-homologous end-joining_Homo sapiens_hsa034501.21456244
31Pentose phosphate pathway_Homo sapiens_hsa000301.20692401
32p53 signaling pathway_Homo sapiens_hsa041151.11535369
33Epstein-Barr virus infection_Homo sapiens_hsa051691.11209571
34Drug metabolism - other enzymes_Homo sapiens_hsa009831.09697542
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.08764243
36Alzheimers disease_Homo sapiens_hsa050101.02674032
37Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.02012621
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.96005347
39Glutathione metabolism_Homo sapiens_hsa004800.94508871
40Cysteine and methionine metabolism_Homo sapiens_hsa002700.90744339
41Antigen processing and presentation_Homo sapiens_hsa046120.89976154
42Primary immunodeficiency_Homo sapiens_hsa053400.88815346
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.82583090
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.76740144
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71433631
46Regulation of autophagy_Homo sapiens_hsa041400.71394639
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.69659235
48Sulfur metabolism_Homo sapiens_hsa009200.69503653
49Biosynthesis of amino acids_Homo sapiens_hsa012300.68907447
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65738157
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63008704
52Fructose and mannose metabolism_Homo sapiens_hsa000510.62303197
53Pyruvate metabolism_Homo sapiens_hsa006200.62138744
54mRNA surveillance pathway_Homo sapiens_hsa030150.61955019
55Metabolic pathways_Homo sapiens_hsa011000.61441731
56Cardiac muscle contraction_Homo sapiens_hsa042600.60297584
57Other glycan degradation_Homo sapiens_hsa005110.56038396
58Legionellosis_Homo sapiens_hsa051340.55775578
59Systemic lupus erythematosus_Homo sapiens_hsa053220.52740952
60Cyanoamino acid metabolism_Homo sapiens_hsa004600.52088281
61SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50227668
62Herpes simplex infection_Homo sapiens_hsa051680.49952604
63N-Glycan biosynthesis_Homo sapiens_hsa005100.49661203
64Graft-versus-host disease_Homo sapiens_hsa053320.49255444
65Shigellosis_Homo sapiens_hsa051310.48920413
66Carbon metabolism_Homo sapiens_hsa012000.47104807
67Galactose metabolism_Homo sapiens_hsa000520.45382896
68Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43135662
69RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.42283831
70Viral carcinogenesis_Homo sapiens_hsa052030.41976408
71Arginine and proline metabolism_Homo sapiens_hsa003300.41849949
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41026159
73Arachidonic acid metabolism_Homo sapiens_hsa005900.39396387
74Fatty acid elongation_Homo sapiens_hsa000620.39009676
75Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.37498436
76Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.36664059
77Selenocompound metabolism_Homo sapiens_hsa004500.34403521
78Allograft rejection_Homo sapiens_hsa053300.33918580
79Apoptosis_Homo sapiens_hsa042100.33369324
80Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.32091260
81Collecting duct acid secretion_Homo sapiens_hsa049660.30913954
822-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.30845660
83Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.30411634
84Steroid biosynthesis_Homo sapiens_hsa001000.29542518
85Thyroid cancer_Homo sapiens_hsa052160.28890491
86Sphingolipid metabolism_Homo sapiens_hsa006000.28600792
87Hematopoietic cell lineage_Homo sapiens_hsa046400.27180072
88Oocyte meiosis_Homo sapiens_hsa041140.26028878
89Intestinal immune network for IgA production_Homo sapiens_hsa046720.25088676
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24718331
91Linoleic acid metabolism_Homo sapiens_hsa005910.23407728
92Renin-angiotensin system_Homo sapiens_hsa046140.22142047
93Peroxisome_Homo sapiens_hsa041460.21261794
94Type I diabetes mellitus_Homo sapiens_hsa049400.20751814
95Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.20684834
96Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.20217508
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.20186628
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.18938220
99Vibrio cholerae infection_Homo sapiens_hsa051100.16753158
100NF-kappa B signaling pathway_Homo sapiens_hsa040640.16526999
101HTLV-I infection_Homo sapiens_hsa051660.15766479
102Vitamin digestion and absorption_Homo sapiens_hsa049770.15398041
103Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.14789270
104Autoimmune thyroid disease_Homo sapiens_hsa053200.14707586
105Rheumatoid arthritis_Homo sapiens_hsa053230.14487297
106Alcoholism_Homo sapiens_hsa050340.14436493
107Lysosome_Homo sapiens_hsa041420.14302613
108Tyrosine metabolism_Homo sapiens_hsa003500.13763274
109Measles_Homo sapiens_hsa051620.13398518
110Glycosaminoglycan degradation_Homo sapiens_hsa005310.13184194
111Asthma_Homo sapiens_hsa053100.12375846
112Viral myocarditis_Homo sapiens_hsa054160.11504337
113Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.10382501
114Ether lipid metabolism_Homo sapiens_hsa005650.10171345
115NOD-like receptor signaling pathway_Homo sapiens_hsa046210.08206345
116Phagosome_Homo sapiens_hsa041450.07748264
117Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.07278581

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