NR1D2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the nuclear hormone receptor family, specifically the NR1 subfamily of receptors. The encoded protein functions as a transcriptional repressor and may play a role in circadian rhythms and carbohydrate and lipid metabolism. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)4.73894847
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.02576706
3L-phenylalanine catabolic process (GO:0006559)4.02576706
4L-phenylalanine metabolic process (GO:0006558)3.79190310
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.79190310
6positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.69041787
7alpha-linolenic acid metabolic process (GO:0036109)3.65247270
8sarcoplasmic reticulum calcium ion transport (GO:0070296)3.62153298
9dicarboxylic acid biosynthetic process (GO:0043650)3.51903871
10muscle filament sliding (GO:0030049)3.46385091
11actin-myosin filament sliding (GO:0033275)3.46385091
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.37444527
13regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.33308930
14lysine metabolic process (GO:0006553)3.32484249
15lysine catabolic process (GO:0006554)3.32484249
16aromatic amino acid family catabolic process (GO:0009074)3.26659163
17glutamate metabolic process (GO:0006536)3.22632258
18actin-mediated cell contraction (GO:0070252)3.15975194
19regulation of cholesterol homeostasis (GO:2000188)3.10701041
20cytoskeletal anchoring at plasma membrane (GO:0007016)3.09643717
21plasma membrane repair (GO:0001778)3.07368070
22regulation of ARF protein signal transduction (GO:0032012)3.05550724
23bile acid biosynthetic process (GO:0006699)3.03692964
24cysteine metabolic process (GO:0006534)3.01516408
25regulation of cell communication by electrical coupling (GO:0010649)3.01250770
26regulation of relaxation of muscle (GO:1901077)2.99781477
27cerebellar granule cell differentiation (GO:0021707)2.98900615
28positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.96046695
29short-chain fatty acid metabolic process (GO:0046459)2.95441557
30cellular ketone body metabolic process (GO:0046950)2.94406886
31sulfur amino acid catabolic process (GO:0000098)2.93345170
32kynurenine metabolic process (GO:0070189)2.92776071
33fatty acid transmembrane transport (GO:1902001)2.92085162
34cellular potassium ion homeostasis (GO:0030007)2.91696255
35positive regulation of fatty acid beta-oxidation (GO:0032000)2.91543701
36high-density lipoprotein particle remodeling (GO:0034375)2.90939266
37regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.88049477
38skeletal muscle contraction (GO:0003009)2.87598055
39actin filament-based movement (GO:0030048)2.86291327
40reverse cholesterol transport (GO:0043691)2.84923176
412-oxoglutarate metabolic process (GO:0006103)2.84439607
42protein carboxylation (GO:0018214)2.83771311
43peptidyl-glutamic acid carboxylation (GO:0017187)2.83771311
44response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.83546886
45amino-acid betaine metabolic process (GO:0006577)2.80995458
46urea metabolic process (GO:0019627)2.79208451
47urea cycle (GO:0000050)2.79208451
48cytoplasmic mRNA processing body assembly (GO:0033962)2.79192028
49fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.78858548
50aspartate family amino acid catabolic process (GO:0009068)2.77377301
51cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.76290999
52carnitine shuttle (GO:0006853)2.75968771
53myofibril assembly (GO:0030239)2.75548169
54vesicle transport along microtubule (GO:0047496)2.74788537
55skin morphogenesis (GO:0043589)2.74253914
56negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.73903099
57hypotonic response (GO:0006971)2.73693929
58striated muscle contraction (GO:0006941)2.72407097
59dicarboxylic acid catabolic process (GO:0043649)2.71707859
60acylglycerol homeostasis (GO:0055090)2.71292734
61triglyceride homeostasis (GO:0070328)2.71292734
62bile acid metabolic process (GO:0008206)2.71014281
63negative regulation of dendrite morphogenesis (GO:0050774)2.70200077
64sodium ion export (GO:0071436)2.67875989
65cardiac muscle contraction (GO:0060048)2.67656886
66positive regulation of glucose import (GO:0046326)2.67164900
67complement activation, alternative pathway (GO:0006957)2.67134196
68indole-containing compound catabolic process (GO:0042436)2.66949842
69indolalkylamine catabolic process (GO:0046218)2.66949842
70tryptophan catabolic process (GO:0006569)2.66949842
71relaxation of cardiac muscle (GO:0055119)2.66928478
72positive regulation of fatty acid oxidation (GO:0046321)2.66047811
73regulation of protein activation cascade (GO:2000257)2.65738752
74gamma-aminobutyric acid transport (GO:0015812)2.65167951
75glyoxylate metabolic process (GO:0046487)2.64520741
76regulation of bile acid biosynthetic process (GO:0070857)2.63055474
77cellular modified amino acid catabolic process (GO:0042219)2.62444115
78myotube differentiation (GO:0014902)2.61824098
79regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.61663112
80locomotory exploration behavior (GO:0035641)2.61662048
81negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.61464504
82homocysteine metabolic process (GO:0050667)2.60942419
83phospholipid homeostasis (GO:0055091)2.60287261
84regulation of transforming growth factor beta2 production (GO:0032909)2.59232733
85drug catabolic process (GO:0042737)2.58715102
86regulation of triglyceride catabolic process (GO:0010896)2.58095442
87alpha-amino acid catabolic process (GO:1901606)2.57687043
88positive regulation of glucose transport (GO:0010828)2.57569008
89macroautophagy (GO:0016236)2.57206825
90fatty acid homeostasis (GO:0055089)2.56636479
91regulation of short-term neuronal synaptic plasticity (GO:0048172)2.56123754
92ketone body metabolic process (GO:1902224)2.56107520
93serine family amino acid catabolic process (GO:0009071)2.56025007
94tryptophan metabolic process (GO:0006568)2.55988626
95synaptic vesicle maturation (GO:0016188)2.55836095
96fatty acid beta-oxidation (GO:0006635)2.55047886
97potassium ion import (GO:0010107)2.54796966
98alanine transport (GO:0032328)2.53317429
99succinate metabolic process (GO:0006105)2.52729948
100skeletal muscle adaptation (GO:0043501)2.52060803
101regulation of complement activation (GO:0030449)2.51722362
102cellular amino acid catabolic process (GO:0009063)2.51519010
103fatty acid oxidation (GO:0019395)2.51055926
104relaxation of muscle (GO:0090075)2.51052346
105nitrogen cycle metabolic process (GO:0071941)2.50913247
106positive regulation of cellular response to insulin stimulus (GO:1900078)2.49997076
107lipid oxidation (GO:0034440)2.49717046
108negative regulation of fibrinolysis (GO:0051918)2.49651036
109regulation of actin filament-based movement (GO:1903115)2.49337646
110regulation of fibrinolysis (GO:0051917)2.48907715
111positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.47318337
112peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.47238341
113positive regulation of lipid catabolic process (GO:0050996)2.46837668
114regulation of fatty acid beta-oxidation (GO:0031998)2.46133268
115detection of calcium ion (GO:0005513)2.45924383
116glutamate secretion (GO:0014047)2.45706083
117plasma lipoprotein particle remodeling (GO:0034369)2.45460723
118protein-lipid complex remodeling (GO:0034368)2.45460723
119macromolecular complex remodeling (GO:0034367)2.45460723
120activation of protein kinase A activity (GO:0034199)2.45333881
121tyrosine metabolic process (GO:0006570)2.44644213
122potassium ion homeostasis (GO:0055075)2.43334497
123regulation of glucocorticoid metabolic process (GO:0031943)2.41551361
124negative regulation of lipase activity (GO:0060192)2.41284263
125regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.40107300
126carnitine metabolic process (GO:0009437)2.39828500
127cellular sodium ion homeostasis (GO:0006883)2.39755839
128cardiac muscle hypertrophy (GO:0003300)2.39391171
129monocarboxylic acid catabolic process (GO:0072329)2.39142726
130striated muscle hypertrophy (GO:0014897)2.39011816
131cell communication by electrical coupling (GO:0010644)2.38977173
132negative regulation of hormone biosynthetic process (GO:0032353)2.38785386
133fatty acid catabolic process (GO:0009062)2.38519332
134cellular response to epinephrine stimulus (GO:0071872)2.38475906
135neurotransmitter secretion (GO:0007269)2.38433455
136linoleic acid metabolic process (GO:0043651)2.37938561
137positive regulation of glycolytic process (GO:0045821)2.37552718
138regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.36978050
139adherens junction assembly (GO:0034333)2.36850048
140positive regulation of macroautophagy (GO:0016239)2.36836919
141cell communication involved in cardiac conduction (GO:0086065)2.36648531
142cell-substrate adherens junction assembly (GO:0007045)2.36461941
143focal adhesion assembly (GO:0048041)2.36461941
144embryonic process involved in female pregnancy (GO:0060136)2.36349920
145neuronal action potential propagation (GO:0019227)2.35907322
146exogenous drug catabolic process (GO:0042738)2.35864407
147clathrin coat assembly (GO:0048268)2.35260605
148regulation of synaptic vesicle exocytosis (GO:2000300)2.34511276
149phospholipid efflux (GO:0033700)2.34467826
150regulation of Rac protein signal transduction (GO:0035020)2.34316592
151negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.34244932
152regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.33335645
153actomyosin structure organization (GO:0031032)2.32823980
154regulation of calcium ion transmembrane transporter activity (GO:1901019)2.32684181
155regulation of calcium ion transmembrane transport (GO:1903169)2.32684181
156coenzyme catabolic process (GO:0009109)2.32294219
157sarcomere organization (GO:0045214)2.32177327
158cellular glucuronidation (GO:0052695)2.32053857
159insulin-like growth factor receptor signaling pathway (GO:0048009)2.31229803
160cardiac myofibril assembly (GO:0055003)2.30862140
161membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.30819708
162cholesterol efflux (GO:0033344)2.30214916
163acetyl-CoA metabolic process (GO:0006084)2.30066381
164valine metabolic process (GO:0006573)2.29697940
165negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.29470170
166regulation of synaptic vesicle transport (GO:1902803)2.28775687
167regulation of cAMP-dependent protein kinase activity (GO:2000479)2.27525354
168positive regulation of insulin receptor signaling pathway (GO:0046628)2.25825323
169regulation of clathrin-mediated endocytosis (GO:2000369)2.24269816
170negative regulation of potassium ion transmembrane transport (GO:1901380)2.23496056
171regulation of neuronal synaptic plasticity (GO:0048168)2.22798985
172embryonic camera-type eye morphogenesis (GO:0048596)2.22391766
173glycogen catabolic process (GO:0005980)2.20963090
174response to inactivity (GO:0014854)2.20742449
175muscle contraction (GO:0006936)2.20267444
176regulation of muscle adaptation (GO:0043502)2.19887360
177striated muscle adaptation (GO:0014888)2.18735569
178cerebellar Purkinje cell differentiation (GO:0021702)2.18586907
179establishment of nucleus localization (GO:0040023)2.18422127
180response to epinephrine (GO:0071871)2.18217508
181protein localization to endosome (GO:0036010)2.17995287
182regulation of p38MAPK cascade (GO:1900744)2.15831981
183myoblast fusion (GO:0007520)2.15797032
184regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.13868908
185regulation of NFAT protein import into nucleus (GO:0051532)2.13125815
186peptidyl-threonine dephosphorylation (GO:0035970)2.12771416
187regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.12204532
188nucleus localization (GO:0051647)2.11507135

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.51044724
2* RXR_22158963_ChIP-Seq_LIVER_Mouse3.44648899
3* LXR_22158963_ChIP-Seq_LIVER_Mouse3.04175706
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.80978244
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.75067278
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.45937386
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.44658000
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.40006606
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.30413297
10TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.15384437
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.85047201
12EZH2_22144423_ChIP-Seq_EOC_Human1.81711480
13GBX2_23144817_ChIP-Seq_PC3_Human1.76646783
14EGR1_23403033_ChIP-Seq_LIVER_Mouse1.75906734
15DROSHA_22980978_ChIP-Seq_HELA_Human1.72142377
16SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.66060691
17CLOCK_20551151_ChIP-Seq_293T_Human1.65552130
18MTF2_20144788_ChIP-Seq_MESCs_Mouse1.62943572
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.57266795
20SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.53614840
21BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.52862494
22DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.52558284
23ZNF217_24962896_ChIP-Seq_MCF-7_Human1.51676982
24PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.49029867
25SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.48753091
26RNF2_18974828_ChIP-Seq_MESCs_Mouse1.46037956
27EZH2_18974828_ChIP-Seq_MESCs_Mouse1.46037956
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.43325432
29* RARB_27405468_Chip-Seq_BRAIN_Mouse1.43210965
30Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.41793667
31FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.41607674
32* FOXA2_19822575_ChIP-Seq_HepG2_Human1.41604734
33ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.41521630
34TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41129493
35SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.40368413
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.39761986
37GATA1_22025678_ChIP-Seq_K562_Human1.39143939
38TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.39071236
39ESR1_20079471_ChIP-ChIP_T-47D_Human1.37917875
40AR_21572438_ChIP-Seq_LNCaP_Human1.36806966
41ESR2_21235772_ChIP-Seq_MCF-7_Human1.35541870
42SALL4_18804426_ChIP-ChIP_XEN_Mouse1.34323662
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.33879380
44WT1_19549856_ChIP-ChIP_CCG9911_Human1.32714390
45FOXM1_26456572_ChIP-Seq_MCF-7_Human1.32237412
46SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.31867803
47SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.27844852
48SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.27844852
49* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.27168516
50* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.25844265
51NFIB_24661679_ChIP-Seq_LUNG_Mouse1.25763143
52CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.24831728
53* CJUN_26792858_Chip-Seq_BT549_Human1.24640543
54TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.24534592
55CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.23339052
56JARID2_20075857_ChIP-Seq_MESCs_Mouse1.23218355
57EP300_21415370_ChIP-Seq_HL-1_Mouse1.23025524
58YAP1_20516196_ChIP-Seq_MESCs_Mouse1.22350870
59BCAT_22108803_ChIP-Seq_LS180_Human1.21219074
60JARID2_20064375_ChIP-Seq_MESCs_Mouse1.20761194
61* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.19964212
62* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.19964212
63THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.19035890
64SMAD4_21799915_ChIP-Seq_A2780_Human1.18883325
65REST_21632747_ChIP-Seq_MESCs_Mouse1.17804176
66AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17213286
67GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.15630800
68BRD4_25478319_ChIP-Seq_HGPS_Human1.14984591
69NR3C1_23031785_ChIP-Seq_PC12_Mouse1.14321188
70OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13791453
71GATA2_21666600_ChIP-Seq_HMVEC_Human1.13509560
72TP53_16413492_ChIP-PET_HCT116_Human1.12134616
73EZH2_27294783_Chip-Seq_ESCs_Mouse1.11783649
74FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10895529
75SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.10339116
76SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.10247921
77ERG_21242973_ChIP-ChIP_JURKAT_Human1.09119919
78ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.08675581
79SUZ12_27294783_Chip-Seq_ESCs_Mouse1.08229724
80RXR_22108803_ChIP-Seq_LS180_Human1.08085279
81EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.07262916
82TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.07075431
83SOX2_21211035_ChIP-Seq_LN229_Gbm1.06813591
84SALL1_21062744_ChIP-ChIP_HESCs_Human1.06250679
85EED_16625203_ChIP-ChIP_MESCs_Mouse1.06176857
86TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06009002
87MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.05897950
88POU3F2_20337985_ChIP-ChIP_501MEL_Human1.05338533
89* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.04953999
90SMAD_19615063_ChIP-ChIP_OVARY_Human1.03860176
91MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03724436
92RARG_19884340_ChIP-ChIP_MEFs_Mouse1.03238500
93TCF4_18268006_ChIP-ChIP_LS174T_Human1.02768740
94WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02439323
95TRIM28_21343339_ChIP-Seq_HEK293_Human1.02426026
96PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.02327140
97FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.02026887
98AHR_22903824_ChIP-Seq_MCF-7_Human1.01941601
99RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01889776
100REST_18959480_ChIP-ChIP_MESCs_Mouse1.01573932
101ISL1_27105846_Chip-Seq_CPCs_Mouse1.00812079
102KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.99882388
103* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.99496574
104* TP63_23658742_ChIP-Seq_EP156T_Human0.99362279
105ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98772391
106EGR1_19374776_ChIP-ChIP_THP-1_Human0.98738976
107ARNT_22903824_ChIP-Seq_MCF-7_Human0.98243410
108RNF2_27304074_Chip-Seq_ESCs_Mouse0.97520508
109AR_25329375_ChIP-Seq_VCAP_Human0.97183100
110SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.96988319
111STAT3_23295773_ChIP-Seq_U87_Human0.96733049
112P300_27058665_Chip-Seq_ZR-75-30cells_Human0.96727670
113TAF15_26573619_Chip-Seq_HEK293_Human0.96679806
114FOXO3_23340844_ChIP-Seq_DLD1_Human0.96200189
115AR_19668381_ChIP-Seq_PC3_Human0.95865085
116STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.95709150
117FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.95145639
118SMAD4_21741376_ChIP-Seq_HESCs_Human0.94909712
119SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94770806
120ESR1_21235772_ChIP-Seq_MCF-7_Human0.94757992
121* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.93351099
122ZNF263_19887448_ChIP-Seq_K562_Human0.93335966
123KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.92647195
124NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92251608
125* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.90925275
126EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.90484523
127KDM2B_26808549_Chip-Seq_K562_Human0.90084826
128ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.89479857
129CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.89266437
130CTBP1_25329375_ChIP-Seq_LNCAP_Human0.89172428
131SMAD3_21741376_ChIP-Seq_HESCs_Human0.87335314
132* TBX20_22080862_ChIP-Seq_HEART_Mouse0.87327465
133* TBX20_22328084_ChIP-Seq_HEART_Mouse0.87327465
134CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.86769986
135EZH2_27304074_Chip-Seq_ESCs_Mouse0.83970054
136WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.82127237
137SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81740712
138TP53_18474530_ChIP-ChIP_U2OS_Human0.80575194
139DNAJC2_21179169_ChIP-ChIP_NT2_Human0.80561990
140NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.80453478
141GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79600532
142SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.79037217
143CTBP2_25329375_ChIP-Seq_LNCAP_Human0.78953215
144SOX9_24532713_ChIP-Seq_HFSC_Mouse0.78597868
145SMAD3_21741376_ChIP-Seq_EPCs_Human0.78578604
146SMAD4_21741376_ChIP-Seq_EPCs_Human0.78535974
147ZNF274_21170338_ChIP-Seq_K562_Hela0.78028896
148CTNNB1_20460455_ChIP-Seq_HCT116_Human0.77765754

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.90166157
2MP0005360_urolithiasis4.20737035
3MP0005085_abnormal_gallbladder_physiolo3.74648583
4MP0005365_abnormal_bile_salt3.73590308
5MP0002009_preneoplasia3.18580902
6MP0008875_abnormal_xenobiotic_pharmacok3.14550891
7MP0003252_abnormal_bile_duct2.81133785
8MP0004859_abnormal_synaptic_plasticity2.64616678
9MP0010352_gastrointestinal_tract_polyps2.60402140
10MP0010329_abnormal_lipoprotein_level2.52252899
11MP0009780_abnormal_chondrocyte_physiolo2.29750524
12MP0002837_dystrophic_cardiac_calcinosis2.22902894
13MP0004130_abnormal_muscle_cell2.19414528
14MP0000759_abnormal_skeletal_muscle2.07734940
15MP0003195_calcinosis2.07499827
16MP0000733_abnormal_muscle_development2.04366245
17MP0004043_abnormal_pH_regulation2.03439153
18MP0002822_catalepsy1.90051699
19MP0005332_abnormal_amino_acid1.88785387
20MP0002909_abnormal_adrenal_gland1.86399578
21MP0005409_darkened_coat_color1.82074372
22MP0000013_abnormal_adipose_tissue1.81685841
23MP0004510_myositis1.75959100
24MP0003635_abnormal_synaptic_transmissio1.74986960
25MP0003828_pulmonary_edema1.71379200
26MP0002118_abnormal_lipid_homeostasis1.68126144
27MP0002106_abnormal_muscle_physiology1.63197080
28MP0004233_abnormal_muscle_weight1.62502800
29MP0001666_abnormal_nutrient_absorption1.62032188
30MP0003690_abnormal_glial_cell1.61146387
31MP0003329_amyloid_beta_deposits1.53849026
32MP0005423_abnormal_somatic_nervous1.51905068
33MP0001501_abnormal_sleep_pattern1.50379637
34MP0010234_abnormal_vibrissa_follicle1.49468922
35MP0005083_abnormal_biliary_tract1.48533798
36MP0005369_muscle_phenotype1.48316522
37MP0003091_abnormal_cell_migration1.46875457
38MP0009046_muscle_twitch1.46177701
39MP0004215_abnormal_myocardial_fiber1.44117817
40MP0000751_myopathy1.44026105
41MP0002108_abnormal_muscle_morphology1.42904984
42MP0009745_abnormal_behavioral_response1.42138358
43MP0009840_abnormal_foam_cell1.40689162
44MP0008438_abnormal_cutaneous_collagen1.39984080
45MP0004270_analgesia1.39474726
46MP0008057_abnormal_DNA_replication1.38129389
47MP0005535_abnormal_body_temperature1.36959416
48MP0002064_seizures1.36755205
49MP0005275_abnormal_skin_tensile1.36120887
50MP0003705_abnormal_hypodermis_morpholog1.36104821
51MP0004019_abnormal_vitamin_homeostasis1.35710880
52MP0005670_abnormal_white_adipose1.34585755
53MP0001299_abnormal_eye_distance/1.34385156
54MP0002090_abnormal_vision1.33294824
55MP0008961_abnormal_basal_metabolism1.32775101
56MP0004036_abnormal_muscle_relaxation1.32297521
57MP0003950_abnormal_plasma_membrane1.30529546
58MP0002063_abnormal_learning/memory/cond1.27341854
59MP0000609_abnormal_liver_physiology1.26243993
60MP0004885_abnormal_endolymph1.26178961
61MP0004145_abnormal_muscle_electrophysio1.25613952
62MP0006138_congestive_heart_failure1.25512465
63MP0005666_abnormal_adipose_tissue1.24867977
64MP0000569_abnormal_digit_pigmentation1.24072488
65MP0002896_abnormal_bone_mineralization1.22826471
66MP0003191_abnormal_cellular_cholesterol1.22406782
67MP0003300_gastrointestinal_ulcer1.22018573
68MP0001502_abnormal_circadian_rhythm1.21818905
69MP0003633_abnormal_nervous_system1.21249572
70MP0002971_abnormal_brown_adipose1.20872789
71MP0002254_reproductive_system_inflammat1.20616246
72MP0010678_abnormal_skin_adnexa1.19884582
73MP0002078_abnormal_glucose_homeostasis1.18601666
74MP0000604_amyloidosis1.17137163
75MP0002138_abnormal_hepatobiliary_system1.16735525
76MP0005167_abnormal_blood-brain_barrier1.16600813
77MP0005646_abnormal_pituitary_gland1.16229573
78MP0005551_abnormal_eye_electrophysiolog1.15797469
79MP0005584_abnormal_enzyme/coenzyme_acti1.13845663
80MP0005623_abnormal_meninges_morphology1.12239764
81MP0002272_abnormal_nervous_system1.11863703
82MP0010368_abnormal_lymphatic_system1.08352117
83MP0003566_abnormal_cell_adhesion1.07755913
84MP0003868_abnormal_feces_composition1.07409467
85MP0010630_abnormal_cardiac_muscle1.07285069
86MP0008569_lethality_at_weaning1.05815270
87MP0005076_abnormal_cell_differentiation1.04984687
88MP0005503_abnormal_tendon_morphology1.04736549
89MP0005248_abnormal_Harderian_gland1.03952659
90MP0003806_abnormal_nucleotide_metabolis1.02709151
91MP0005319_abnormal_enzyme/_coenzyme1.02622205
92MP0001486_abnormal_startle_reflex1.02083425
93MP0002572_abnormal_emotion/affect_behav1.01534478
94MP0003045_fibrosis1.01493934
95MP0001348_abnormal_lacrimal_gland1.01289561
96MP0003283_abnormal_digestive_organ1.00555568
97MP0005187_abnormal_penis_morphology1.00234311
98MP0000750_abnormal_muscle_regeneration0.99863178
99MP0000920_abnormal_myelination0.99443347
100MP0004084_abnormal_cardiac_muscle0.99263415
101MP0005257_abnormal_intraocular_pressure0.98959598
102MP0001440_abnormal_grooming_behavior0.98652316
103MP0005375_adipose_tissue_phenotype0.97242398
104MP0009115_abnormal_fat_cell0.96981431
105MP0005620_abnormal_muscle_contractility0.96964203
106MP0000747_muscle_weakness0.96351260
107MP0005330_cardiomyopathy0.95353756
108MP0001851_eye_inflammation0.94700206
109MP0004134_abnormal_chest_morphology0.93856772
110MP0003075_altered_response_to0.92987975
111MP0002060_abnormal_skin_morphology0.92624955
112MP0002876_abnormal_thyroid_physiology0.92246537
113MP0003880_abnormal_central_pattern0.91394198
114MP0002269_muscular_atrophy0.90719936
115MP0001958_emphysema0.90628308
116MP0008874_decreased_physiological_sensi0.90193272
117MP0000003_abnormal_adipose_tissue0.88803772
118MP0003646_muscle_fatigue0.87747260
119MP0002877_abnormal_melanocyte_morpholog0.86647344
120MP0003453_abnormal_keratinocyte_physiol0.86451336
121MP0000749_muscle_degeneration0.86086817
122MP0003279_aneurysm0.85827412
123MP0001765_abnormal_ion_homeostasis0.83147955
124MP0004087_abnormal_muscle_fiber0.82979160
125MP0003634_abnormal_glial_cell0.81347944
126MP0009643_abnormal_urine_homeostasis0.80922858
127MP0004484_altered_response_of0.80277034
128MP0002067_abnormal_sensory_capabilities0.79935857
129MP0005334_abnormal_fat_pad0.79358943
130MP0004085_abnormal_heartbeat0.78592709
131MP0003879_abnormal_hair_cell0.77724570
132MP0003631_nervous_system_phenotype0.77338249
133MP0004185_abnormal_adipocyte_glucose0.74584992
134MP0005023_abnormal_wound_healing0.74268340
135MP0000230_abnormal_systemic_arterial0.73928129
136MP0002972_abnormal_cardiac_muscle0.73750750
137MP0005386_behavior/neurological_phenoty0.73306044
138MP0004924_abnormal_behavior0.73306044
139MP0002332_abnormal_exercise_endurance0.72960586
140MP0005448_abnormal_energy_balance0.71382598
141MP0000428_abnormal_craniofacial_morphol0.70770049
142MP0002734_abnormal_mechanical_nocicepti0.70356351
143MP0002166_altered_tumor_susceptibility0.69752135
144MP0001177_atelectasis0.69163416
145MP0002998_abnormal_bone_remodeling0.68309222
146MP0001879_abnormal_lymphatic_vessel0.66009879
147MP0001544_abnormal_cardiovascular_syste0.63515313
148MP0005385_cardiovascular_system_phenoty0.63515313

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)5.43591720
2Nemaline bodies (HP:0003798)5.41052759
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.26458844
4Type 1 muscle fiber predominance (HP:0003803)4.68501314
5Deep venous thrombosis (HP:0002625)4.04108268
6Abnormality of aromatic amino acid family metabolism (HP:0004338)3.91272422
7Xanthomatosis (HP:0000991)3.80387743
8Intrahepatic cholestasis (HP:0001406)3.76005163
9Abnormality of the left ventricular outflow tract (HP:0011103)3.72154437
10Subaortic stenosis (HP:0001682)3.72154437
11Ketosis (HP:0001946)3.63079490
12Ketoacidosis (HP:0001993)3.55013551
13Hypoglycemic coma (HP:0001325)3.54057734
14Hypoalphalipoproteinemia (HP:0003233)3.52185012
15Hyperlipoproteinemia (HP:0010980)3.43478002
16Focal motor seizures (HP:0011153)3.20072307
17Complement deficiency (HP:0004431)3.11841925
18EMG: myopathic abnormalities (HP:0003458)3.09780480
19Exercise-induced myalgia (HP:0003738)3.02019491
20Asymmetric septal hypertrophy (HP:0001670)3.01872128
21Abnormality of monocarboxylic acid metabolism (HP:0010996)3.01726586
22Obstructive sleep apnea (HP:0002870)3.01040696
23Hypolipoproteinemia (HP:0010981)3.00929007
24Hyperammonemia (HP:0001987)2.99994805
25Prolonged partial thromboplastin time (HP:0003645)2.99048486
26Hyperglycinemia (HP:0002154)2.98071059
27Muscle fiber splitting (HP:0003555)2.97746090
28Hyperglycinuria (HP:0003108)2.96909531
29Gout (HP:0001997)2.91673978
30Abnormality of serine family amino acid metabolism (HP:0010894)2.81462117
31Abnormality of glycine metabolism (HP:0010895)2.81462117
32Abnormality of skeletal muscle fiber size (HP:0012084)2.81331874
33Round ear (HP:0100830)2.79269299
34Myoglobinuria (HP:0002913)2.75469644
35Hypobetalipoproteinemia (HP:0003563)2.75256038
36Increased variability in muscle fiber diameter (HP:0003557)2.72205970
37Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.71358936
38Hyperinsulinemic hypoglycemia (HP:0000825)2.71344150
39Epidermoid cyst (HP:0200040)2.67202480
40Abnormality of the common coagulation pathway (HP:0010990)2.66285939
41Action tremor (HP:0002345)2.64064207
42Frequent falls (HP:0002359)2.61642280
43Increased connective tissue (HP:0009025)2.61543742
44Hypoglycemic seizures (HP:0002173)2.61474618
45Visual hallucinations (HP:0002367)2.59125743
46Arterial tortuosity (HP:0005116)2.56713180
47Dysmetric saccades (HP:0000641)2.55279401
48Abnormality of the calf musculature (HP:0001430)2.54277676
49Distal arthrogryposis (HP:0005684)2.52926373
50Protrusio acetabuli (HP:0003179)2.51206449
51Neck muscle weakness (HP:0000467)2.47557887
52Skin nodule (HP:0200036)2.46514211
53Distal lower limb muscle weakness (HP:0009053)2.45227625
54Osteolytic defects of the phalanges of the hand (HP:0009771)2.45054929
55Osteolytic defects of the hand bones (HP:0009699)2.45054929
56Status epilepticus (HP:0002133)2.44803333
57Abnormality of glutamine family amino acid metabolism (HP:0010902)2.42639136
58Overgrowth (HP:0001548)2.41930804
59Abnormality of the intrinsic pathway (HP:0010989)2.40809415
60Focal seizures (HP:0007359)2.39837451
61Vascular tortuosity (HP:0004948)2.39580682
62Ulnar deviation of the wrist (HP:0003049)2.38405300
63Centrally nucleated skeletal muscle fibers (HP:0003687)2.37429996
64Exercise-induced muscle cramps (HP:0003710)2.37244769
65Hyperglycemia (HP:0003074)2.32142985
66Abnormality of purine metabolism (HP:0004352)2.30883307
67Hyperventilation (HP:0002883)2.26494432
68Aortic aneurysm (HP:0004942)2.25800171
69Febrile seizures (HP:0002373)2.22679565
70Papilledema (HP:0001085)2.22428139
71Mildly elevated creatine phosphokinase (HP:0008180)2.21837958
72Absence seizures (HP:0002121)2.21641780
73Distal lower limb amyotrophy (HP:0008944)2.19508417
74Dysdiadochokinesis (HP:0002075)2.18851486
75Hyporeflexia of lower limbs (HP:0002600)2.16144759
76Lower limb amyotrophy (HP:0007210)2.15070406
77Intention tremor (HP:0002080)2.14724056
78Abnormal atrioventricular conduction (HP:0005150)2.12589106
79Abnormality of fatty-acid metabolism (HP:0004359)2.11198535
80Impaired social interactions (HP:0000735)2.10983686
81Abnormal social behavior (HP:0012433)2.10983686
82Papillary thyroid carcinoma (HP:0002895)2.09062165
83Conjugated hyperbilirubinemia (HP:0002908)2.08494205
84Right ventricular cardiomyopathy (HP:0011663)2.07974872
85Spinal rigidity (HP:0003306)2.07962209
86Generalized tonic-clonic seizures (HP:0002069)2.07956025
87Scapular winging (HP:0003691)2.05775540
88Bundle branch block (HP:0011710)2.04997274
89Atonic seizures (HP:0010819)2.04433098
90Fat malabsorption (HP:0002630)2.01710628
91Myokymia (HP:0002411)2.01245169
92Increased purine levels (HP:0004368)2.00316519
93Hyperuricemia (HP:0002149)2.00316519
94EMG: neuropathic changes (HP:0003445)2.00021712
95Hypercholesterolemia (HP:0003124)1.99200716
96Global brain atrophy (HP:0002283)1.99020644
97Cubitus valgus (HP:0002967)1.98089649
98Postural instability (HP:0002172)1.97598674
99Metabolic acidosis (HP:0001942)1.96622407
100Central scotoma (HP:0000603)1.95916295
101Symptomatic seizures (HP:0011145)1.95647502
102Abnormality of complement system (HP:0005339)1.95553702
103Rimmed vacuoles (HP:0003805)1.94306584
104Difficulty running (HP:0009046)1.93627771
105Abnormality of the Achilles tendon (HP:0005109)1.93231521
106Abnormality of sulfur amino acid metabolism (HP:0004339)1.92748567
107Syncope (HP:0001279)1.92128754
108Myocardial infarction (HP:0001658)1.92102438
109Menstrual irregularities (HP:0000858)1.90115014
110Sensorimotor neuropathy (HP:0007141)1.89455631
111Neurofibrillary tangles (HP:0002185)1.88693355
112Sudden death (HP:0001699)1.88541596
113Pigmentary retinal degeneration (HP:0001146)1.88423015
114Tetraplegia (HP:0002445)1.87636078
115Anxiety (HP:0000739)1.87345674
116Resting tremor (HP:0002322)1.86594288
117Atrioventricular block (HP:0001678)1.85742786
118Delayed CNS myelination (HP:0002188)1.85307583
119Supranuclear gaze palsy (HP:0000605)1.85283953
120Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.83983562
121Hemiplegia (HP:0002301)1.83518176
122Dialeptic seizures (HP:0011146)1.83372440
123Hyperkalemia (HP:0002153)1.82891180
124Abnormal gallbladder morphology (HP:0012437)1.82392872
125Abnormality of aspartate family amino acid metabolism (HP:0010899)1.82216193
126Poor eye contact (HP:0000817)1.82045241
127Cholelithiasis (HP:0001081)1.81430979
128Subacute progressive viral hepatitis (HP:0006572)1.79952281
129Muscle hypertrophy of the lower extremities (HP:0008968)1.79277047
130Ventricular tachycardia (HP:0004756)1.79267859
131Depression (HP:0000716)1.79101046
132Ventricular fibrillation (HP:0001663)1.78893848
133Calf muscle hypertrophy (HP:0008981)1.78700987
134Joint hemorrhage (HP:0005261)1.78437771
135Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.76985618
136Progressive cerebellar ataxia (HP:0002073)1.75792869
137Heart block (HP:0012722)1.75644750
138Pheochromocytoma (HP:0002666)1.75639629
139Myopathic facies (HP:0002058)1.75522453
140Cerebral inclusion bodies (HP:0100314)1.75268567
141Scanning speech (HP:0002168)1.73917247
142Truncal ataxia (HP:0002078)1.73470673
143Late onset (HP:0003584)1.73100230
144Proximal amyotrophy (HP:0007126)1.71262646
145Dysmetria (HP:0001310)1.70303322
146Retinal atrophy (HP:0001105)1.68273127
147Insulin-resistant diabetes mellitus (HP:0000831)1.67809219
148Mitral stenosis (HP:0001718)1.66572287
149Rhabdomyolysis (HP:0003201)1.66184220
150Cerebral aneurysm (HP:0004944)1.65213766
151Areflexia of lower limbs (HP:0002522)1.64153499
152Persistence of primary teeth (HP:0006335)1.62301992
153Reduced subcutaneous adipose tissue (HP:0003758)1.61045455
154Striae distensae (HP:0001065)1.60467820
155Mitral valve prolapse (HP:0001634)1.59856944
156Aortic dissection (HP:0002647)1.57118285
157Calcaneovalgus deformity (HP:0001848)1.56821257
158Hypoplasia of the iris (HP:0007676)1.56768839
159Relative macrocephaly (HP:0004482)1.56181614
160Gowers sign (HP:0003391)1.55581804
161Glucose intolerance (HP:0000833)1.55452418
162Limited hip movement (HP:0008800)1.55396994
163Foot dorsiflexor weakness (HP:0009027)1.55201270
164Malignant hyperthermia (HP:0002047)1.54560708
165Fetal akinesia sequence (HP:0001989)1.53436287
166Hip contracture (HP:0003273)1.52588930
167Ventricular arrhythmia (HP:0004308)1.51441802
168Slender build (HP:0001533)1.51116817
169Aneurysm (HP:0002617)1.49897765
170Mild short stature (HP:0003502)1.49659348
171Muscle stiffness (HP:0003552)1.49589249
172Wormian bones (HP:0002645)1.48803154
173Spondylolisthesis (HP:0003302)1.48689667

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K22.76470639
2EPHA42.69987792
3NTRK32.43477588
4LATS22.34204796
5INSRR2.32531966
6RIPK12.25938346
7FRK2.25911713
8MAP2K42.17324427
9BCKDK2.06236253
10TRIB32.04536341
11MAP3K41.99950388
12TRPM71.90080835
13SIK11.89838800
14PINK11.84027698
15MAP3K91.73391287
16PRPF4B1.70110800
17DAPK21.67693230
18NEK91.64179719
19KSR21.58890513
20MAP3K121.51831358
21CAMKK11.51191149
22LMTK21.48843015
23PHKG21.47499275
24PHKG11.47499275
25EEF2K1.44656595
26FGFR21.44473301
27CAMKK21.42275791
28STK381.41046169
29TTN1.40684969
30PRKD31.39401163
31ERBB31.38356136
32PDK31.37873717
33PDK41.37873717
34ICK1.37840637
35MAP3K71.34355481
36SGK31.29939297
37CDK121.29677991
38RET1.29626590
39SGK21.27276481
40FGFR41.25994585
41NTRK11.21876098
42PRKCH1.21761715
43PAK61.20262417
44MAP3K31.16108715
45SGK2231.14928312
46SGK4941.14928312
47NEK61.11458140
48TAOK31.11396948
49CAMK1G1.10330508
50PTK61.09143045
51CAMK1D1.05591405
52MOS1.03788582
53UHMK11.03721197
54FER1.02566141
55BRD41.02518381
56MINK11.01951550
57PDK21.00468803
58NLK1.00307525
59DMPK0.99914879
60PDGFRA0.99613107
61OBSCN0.99101665
62MET0.98643646
63WNK10.98429667
64JAK10.97576412
65PKN20.94528319
66TIE10.92611686
67PDPK10.91973940
68LATS10.90836009
69MAPK150.89928765
70FGFR30.89684133
71MAP2K70.89460597
72NTRK20.89413999
73PAK30.88448705
74MAP3K10.86263642
75STK30.86257972
76MAPK70.85884171
77ERN10.85260645
78STK240.85112887
79MARK20.82138178
80WNK40.81837188
81EPHA20.80440600
82BMPR20.80252966
83PDK10.79363682
84RIPK40.78817827
85STK110.76213440
86CDK50.76191252
87PRKAA20.75974216
88JAK20.75422363
89MAPK120.74373556
90MAPK100.73332532
91MTOR0.72882677
92MELK0.72655542
93MAP3K100.71955872
94SGK10.71787439
95STK38L0.70460526
96PRKAA10.69128245
97MAP2K10.69019288
98CAMK2G0.67603028
99TYRO30.66273112
100MAP3K130.65106811
101CDC42BPA0.64896874
102MST1R0.63568413
103CDK60.63069366
104CAMK2B0.62096299
105HIPK20.61776434
106AKT30.61643004
107GRK50.61484485
108SCYL20.61317036
109PRKD10.59829752
110MYLK0.59389429
111CAMK2A0.58198183
112CAMK40.57994027
113YES10.57749049
114PNCK0.56209218
115OXSR10.55734471
116PTK20.55555996
117CAMK2D0.55440698
118PRKCG0.54751597
119STK390.54513665
120CAMK10.53757517
121DDR20.53296500
122PIK3CA0.51532595
123SIK20.51119316
124RPS6KA30.49206210
125DYRK1A0.48616326
126MAP2K30.48368708
127PRKACG0.47238526
128RPS6KB10.46410888
129FGFR10.46140125
130PDGFRB0.45578205
131KSR10.45296554
132NEK10.44395508
133ROCK20.44313544
134MAP2K20.42656537
135PIK3CG0.42547470
136TGFBR20.41030745
137PRKCE0.41025114

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.03300624
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.66933036
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.58833228
4Arginine biosynthesis_Homo sapiens_hsa002202.44097368
5Fatty acid degradation_Homo sapiens_hsa000712.14867236
6Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.02424797
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.89719333
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.85689829
9Butanoate metabolism_Homo sapiens_hsa006501.84632254
10Propanoate metabolism_Homo sapiens_hsa006401.84416090
11Fatty acid metabolism_Homo sapiens_hsa012121.70474471
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.67648501
13Tryptophan metabolism_Homo sapiens_hsa003801.66828022
14Bile secretion_Homo sapiens_hsa049761.66196211
15PPAR signaling pathway_Homo sapiens_hsa033201.60084593
16Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.51561893
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.51424730
18Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.49140600
19Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.45119171
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.41149256
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.38294350
22Complement and coagulation cascades_Homo sapiens_hsa046101.34136236
23Adherens junction_Homo sapiens_hsa045201.33567352
24Thyroid hormone signaling pathway_Homo sapiens_hsa049191.30773384
25Glioma_Homo sapiens_hsa052141.30634638
26mTOR signaling pathway_Homo sapiens_hsa041501.29562359
27GABAergic synapse_Homo sapiens_hsa047271.24570636
28Sulfur metabolism_Homo sapiens_hsa009201.21992533
29Inositol phosphate metabolism_Homo sapiens_hsa005621.20863387
30Fatty acid biosynthesis_Homo sapiens_hsa000611.20768645
31Endometrial cancer_Homo sapiens_hsa052131.19985082
32Thyroid cancer_Homo sapiens_hsa052161.18979378
33Renal cell carcinoma_Homo sapiens_hsa052111.18616196
34Focal adhesion_Homo sapiens_hsa045101.16087662
35ErbB signaling pathway_Homo sapiens_hsa040121.16031131
36FoxO signaling pathway_Homo sapiens_hsa040681.15036284
37Nicotine addiction_Homo sapiens_hsa050331.12507702
38Insulin secretion_Homo sapiens_hsa049111.10161518
39Neurotrophin signaling pathway_Homo sapiens_hsa047221.09646205
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.09089000
41Peroxisome_Homo sapiens_hsa041461.08618033
42beta-Alanine metabolism_Homo sapiens_hsa004101.08092114
43Non-small cell lung cancer_Homo sapiens_hsa052231.07887154
44Circadian entrainment_Homo sapiens_hsa047131.07636289
45Pentose and glucuronate interconversions_Homo sapiens_hsa000401.07595720
46Proteoglycans in cancer_Homo sapiens_hsa052051.06518453
47Maturity onset diabetes of the young_Homo sapiens_hsa049501.06013395
48Starch and sucrose metabolism_Homo sapiens_hsa005001.04125557
49Phospholipase D signaling pathway_Homo sapiens_hsa040721.03472860
50Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.03000216
51Chronic myeloid leukemia_Homo sapiens_hsa052201.00708480
52ABC transporters_Homo sapiens_hsa020101.00398548
53Pyruvate metabolism_Homo sapiens_hsa006200.99721526
54Long-term potentiation_Homo sapiens_hsa047200.99319197
55Melanogenesis_Homo sapiens_hsa049160.98644963
56Circadian rhythm_Homo sapiens_hsa047100.98062081
57Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.97797913
58Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.97737994
59Type II diabetes mellitus_Homo sapiens_hsa049300.96957310
60Salivary secretion_Homo sapiens_hsa049700.95744991
61Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.95326120
62AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.95080642
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.94903626
64Glutamatergic synapse_Homo sapiens_hsa047240.94613454
65Aldosterone synthesis and secretion_Homo sapiens_hsa049250.92297948
66Caffeine metabolism_Homo sapiens_hsa002320.91964359
67Synaptic vesicle cycle_Homo sapiens_hsa047210.91959429
68Phenylalanine metabolism_Homo sapiens_hsa003600.91398398
69Gastric acid secretion_Homo sapiens_hsa049710.90039584
70Choline metabolism in cancer_Homo sapiens_hsa052310.89689526
71Prolactin signaling pathway_Homo sapiens_hsa049170.89096587
72VEGF signaling pathway_Homo sapiens_hsa043700.88804030
73Renin secretion_Homo sapiens_hsa049240.88221224
74Amphetamine addiction_Homo sapiens_hsa050310.88054375
75Tight junction_Homo sapiens_hsa045300.87375949
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86828411
77Morphine addiction_Homo sapiens_hsa050320.86783537
78Chemical carcinogenesis_Homo sapiens_hsa052040.85419704
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.84087109
80MAPK signaling pathway_Homo sapiens_hsa040100.83702304
81Glucagon signaling pathway_Homo sapiens_hsa049220.82594136
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.81602435
83Prostate cancer_Homo sapiens_hsa052150.81286023
84Insulin resistance_Homo sapiens_hsa049310.80194302
85Amoebiasis_Homo sapiens_hsa051460.79673102
86Glycerolipid metabolism_Homo sapiens_hsa005610.79484875
87Histidine metabolism_Homo sapiens_hsa003400.79467565
88Carbon metabolism_Homo sapiens_hsa012000.78698319
89ECM-receptor interaction_Homo sapiens_hsa045120.77521772
90Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.75505347
91Olfactory transduction_Homo sapiens_hsa047400.75330385
92Pancreatic cancer_Homo sapiens_hsa052120.75154056
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75135658
94Gap junction_Homo sapiens_hsa045400.73973862
95Leukocyte transendothelial migration_Homo sapiens_hsa046700.73692054
96Retinol metabolism_Homo sapiens_hsa008300.71329441
97Tyrosine metabolism_Homo sapiens_hsa003500.70000923
98Colorectal cancer_Homo sapiens_hsa052100.69911547
99Fat digestion and absorption_Homo sapiens_hsa049750.69769318
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.69461038
101Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.68835488
102Steroid hormone biosynthesis_Homo sapiens_hsa001400.68062881
103Platelet activation_Homo sapiens_hsa046110.66267861
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.65964509
105Glycosaminoglycan degradation_Homo sapiens_hsa005310.65284891
106Oxytocin signaling pathway_Homo sapiens_hsa049210.64755433
107Dopaminergic synapse_Homo sapiens_hsa047280.64663653
108Ras signaling pathway_Homo sapiens_hsa040140.64379058
109Taste transduction_Homo sapiens_hsa047420.64088905
110Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63890475
111Rap1 signaling pathway_Homo sapiens_hsa040150.63502537
112Thyroid hormone synthesis_Homo sapiens_hsa049180.63199404
113Hippo signaling pathway_Homo sapiens_hsa043900.63061660
114GnRH signaling pathway_Homo sapiens_hsa049120.61321047
115Endocytosis_Homo sapiens_hsa041440.61042859
116Phosphatidylinositol signaling system_Homo sapiens_hsa040700.60850023
117Lysine degradation_Homo sapiens_hsa003100.60160395
118Cholinergic synapse_Homo sapiens_hsa047250.60098469
119Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59961538
120Cocaine addiction_Homo sapiens_hsa050300.59783274
121Small cell lung cancer_Homo sapiens_hsa052220.59702687
122Wnt signaling pathway_Homo sapiens_hsa043100.59291263
123Dilated cardiomyopathy_Homo sapiens_hsa054140.57749460
124cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57384920
125MicroRNAs in cancer_Homo sapiens_hsa052060.57312527
126Calcium signaling pathway_Homo sapiens_hsa040200.57241441
127cAMP signaling pathway_Homo sapiens_hsa040240.57135768
128Fatty acid elongation_Homo sapiens_hsa000620.56490205
129Biosynthesis of amino acids_Homo sapiens_hsa012300.56325278
130Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55390403
131Dorso-ventral axis formation_Homo sapiens_hsa043200.54951545
132Staphylococcus aureus infection_Homo sapiens_hsa051500.54337904
133Pancreatic secretion_Homo sapiens_hsa049720.54332817
134Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53646379
135Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52144114
136Melanoma_Homo sapiens_hsa052180.51880763
137Insulin signaling pathway_Homo sapiens_hsa049100.51824193
138Long-term depression_Homo sapiens_hsa047300.50161264
139T cell receptor signaling pathway_Homo sapiens_hsa046600.49923480
140AMPK signaling pathway_Homo sapiens_hsa041520.49760771
141Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48489900
142Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.48061992
143Vascular smooth muscle contraction_Homo sapiens_hsa042700.46757653
144Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46337772
145Selenocompound metabolism_Homo sapiens_hsa004500.45707363
146Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45266273
147Prion diseases_Homo sapiens_hsa050200.44934537
148Estrogen signaling pathway_Homo sapiens_hsa049150.44769867

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