NR0B2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.43724284
2L-phenylalanine catabolic process (GO:0006559)7.43724284
3L-phenylalanine metabolic process (GO:0006558)7.17848489
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.17848489
5aromatic amino acid family catabolic process (GO:0009074)6.68309162
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.27860063
7tryptophan catabolic process (GO:0006569)6.06782028
8indole-containing compound catabolic process (GO:0042436)6.06782028
9indolalkylamine catabolic process (GO:0046218)6.06782028
10kynurenine metabolic process (GO:0070189)5.97942840
11bile acid biosynthetic process (GO:0006699)5.88753129
12glyoxylate metabolic process (GO:0046487)5.83953389
13tryptophan metabolic process (GO:0006568)5.68091505
14high-density lipoprotein particle remodeling (GO:0034375)5.54105288
15alpha-linolenic acid metabolic process (GO:0036109)5.50659684
16negative regulation of fibrinolysis (GO:0051918)5.42276146
17urea metabolic process (GO:0019627)5.33425302
18urea cycle (GO:0000050)5.33425302
19regulation of plasminogen activation (GO:0010755)5.31929858
20cysteine metabolic process (GO:0006534)5.29932685
21sulfur amino acid catabolic process (GO:0000098)5.23269552
22regulation of fibrinolysis (GO:0051917)5.21090461
23complement activation, alternative pathway (GO:0006957)5.18550977
24regulation of protein activation cascade (GO:2000257)5.16247608
25peptidyl-glutamic acid carboxylation (GO:0017187)5.14413273
26protein carboxylation (GO:0018214)5.14413273
27protein-lipid complex assembly (GO:0065005)5.05653509
28serine family amino acid catabolic process (GO:0009071)5.01080675
29fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.97615842
30bile acid metabolic process (GO:0008206)4.97457471
31regulation of cholesterol esterification (GO:0010872)4.93792769
32nitrogen cycle metabolic process (GO:0071941)4.92617697
33negative regulation of protein activation cascade (GO:2000258)4.91552755
34regulation of triglyceride catabolic process (GO:0010896)4.89478580
35aromatic amino acid family metabolic process (GO:0009072)4.85190238
36regulation of complement activation (GO:0030449)4.82412266
37protein-lipid complex remodeling (GO:0034368)4.78413172
38macromolecular complex remodeling (GO:0034367)4.78413172
39plasma lipoprotein particle remodeling (GO:0034369)4.78413172
40reverse cholesterol transport (GO:0043691)4.75046966
41lysine metabolic process (GO:0006553)4.74714464
42lysine catabolic process (GO:0006554)4.74714464
43regulation of apoptotic cell clearance (GO:2000425)4.64774229
44alpha-amino acid catabolic process (GO:1901606)4.61659476
45phospholipid efflux (GO:0033700)4.61351490
46protein-lipid complex subunit organization (GO:0071825)4.60346148
47homocysteine metabolic process (GO:0050667)4.59294188
48glycine metabolic process (GO:0006544)4.57464582
49intestinal absorption (GO:0050892)4.55405945
50negative regulation of cholesterol transport (GO:0032375)4.53824783
51negative regulation of sterol transport (GO:0032372)4.53824783
52amino-acid betaine metabolic process (GO:0006577)4.51775486
53epoxygenase P450 pathway (GO:0019373)4.50630388
54acylglycerol homeostasis (GO:0055090)4.50405814
55triglyceride homeostasis (GO:0070328)4.50405814
56coenzyme catabolic process (GO:0009109)4.50243874
57tyrosine metabolic process (GO:0006570)4.49567875
58cellular ketone body metabolic process (GO:0046950)4.45582522
59regulation of bile acid biosynthetic process (GO:0070857)4.40121977
60acute-phase response (GO:0006953)4.40094740
61plasma lipoprotein particle clearance (GO:0034381)4.31364282
62negative regulation of complement activation (GO:0045916)4.30425753
63cellular amino acid catabolic process (GO:0009063)4.27376796
64bile acid and bile salt transport (GO:0015721)4.26581454
65serine family amino acid metabolic process (GO:0009069)4.25188223
66indolalkylamine metabolic process (GO:0006586)4.25012901
67amine catabolic process (GO:0009310)4.21672008
68cellular biogenic amine catabolic process (GO:0042402)4.21672008
69serine family amino acid biosynthetic process (GO:0009070)4.18065769
70imidazole-containing compound metabolic process (GO:0052803)4.17550821
71negative regulation of hemostasis (GO:1900047)4.15338365
72negative regulation of blood coagulation (GO:0030195)4.15338365
73benzene-containing compound metabolic process (GO:0042537)4.15191271
74cellular modified amino acid catabolic process (GO:0042219)4.11128181
75proline metabolic process (GO:0006560)4.10343315
76cholesterol efflux (GO:0033344)4.09938142
77ethanol oxidation (GO:0006069)4.08053382
78glutamate metabolic process (GO:0006536)4.07676712
79cellular glucuronidation (GO:0052695)4.05664165
80low-density lipoprotein particle remodeling (GO:0034374)3.99381710
81plasma lipoprotein particle assembly (GO:0034377)3.95748507
82cholesterol transport (GO:0030301)3.94734611
83sterol transport (GO:0015918)3.94734611
84regulation of humoral immune response (GO:0002920)3.94317194
85regulation of cholesterol homeostasis (GO:2000188)3.93935333
86negative regulation of coagulation (GO:0050819)3.91480042
87positive regulation of fatty acid biosynthetic process (GO:0045723)3.91415484
88positive regulation of hemostasis (GO:1900048)3.89791040
89positive regulation of blood coagulation (GO:0030194)3.89791040
90intestinal cholesterol absorption (GO:0030299)3.86858856
91sterol homeostasis (GO:0055092)3.85034353
92ketone body metabolic process (GO:1902224)3.84925658
93dicarboxylic acid biosynthetic process (GO:0043650)3.84747709
94cofactor catabolic process (GO:0051187)3.83438019
95aldehyde catabolic process (GO:0046185)3.82768246
96positive regulation of lipoprotein lipase activity (GO:0051006)3.81318924
97positive regulation of triglyceride lipase activity (GO:0061365)3.81318924
98arginine metabolic process (GO:0006525)3.80413549
99carboxylic acid catabolic process (GO:0046395)3.80309074
100organic acid catabolic process (GO:0016054)3.80309074
101blood coagulation, intrinsic pathway (GO:0007597)3.78240087
102fibrinolysis (GO:0042730)3.76076093
103short-chain fatty acid metabolic process (GO:0046459)3.75454403
104very-low-density lipoprotein particle assembly (GO:0034379)3.75403324
105negative regulation of lipase activity (GO:0060192)3.70733647
106complement activation, classical pathway (GO:0006958)3.69866143
107aspartate family amino acid catabolic process (GO:0009068)3.69288295
108positive regulation of lipid catabolic process (GO:0050996)3.69006304
109negative regulation of wound healing (GO:0061045)3.68804908
110drug catabolic process (GO:0042737)3.68737687
111acetyl-CoA metabolic process (GO:0006084)3.68381372
112lipoprotein metabolic process (GO:0042157)3.67423526
113cholesterol homeostasis (GO:0042632)3.65132658
114NAD biosynthetic process (GO:0009435)3.63759075
115complement activation (GO:0006956)3.63440599
116ethanol metabolic process (GO:0006067)3.62865726
117exogenous drug catabolic process (GO:0042738)3.62691144
1182-oxoglutarate metabolic process (GO:0006103)3.62174492
119cytolysis (GO:0019835)3.61981196
120protein activation cascade (GO:0072376)3.60869962
121plasma lipoprotein particle organization (GO:0071827)3.60709684
122pyridine nucleotide biosynthetic process (GO:0019363)3.59424993
123nicotinamide nucleotide biosynthetic process (GO:0019359)3.59424993
124heme transport (GO:0015886)3.58203782
125uronic acid metabolic process (GO:0006063)3.58007333
126glucuronate metabolic process (GO:0019585)3.58007333
127positive regulation of coagulation (GO:0050820)3.57054110
128omega-hydroxylase P450 pathway (GO:0097267)3.53005765
129regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.49287064
130positive regulation of steroid metabolic process (GO:0045940)3.47621092
131peptidyl-glutamic acid modification (GO:0018200)3.40372498
132phenylpropanoid metabolic process (GO:0009698)3.38594078
133diacylglycerol metabolic process (GO:0046339)3.38117151
134lipid homeostasis (GO:0055088)3.33586454
135negative regulation of humoral immune response (GO:0002921)3.29415852
136positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.29286927
137acute inflammatory response (GO:0002526)3.26622998
138drug metabolic process (GO:0017144)3.09284750
139negative regulation of digestive system process (GO:0060457)3.06705858
140regulation of cholesterol biosynthetic process (GO:0045540)3.04010404

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.19183557
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.15985673
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.92941147
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.26603428
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.37155344
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.19283918
7* FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.07875228
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.06990188
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.83157848
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.30017138
11* HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.11376921
12* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.8375729
13TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.99361092
14CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.89597852
15GATA1_22025678_ChIP-Seq_K562_Human1.82140622
16HTT_18923047_ChIP-ChIP_STHdh_Human1.55998646
17PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.53997411
18* FOXO3_23340844_ChIP-Seq_DLD1_Human1.50739795
19CLOCK_20551151_ChIP-Seq_293T_Human1.45963246
20* FOXA2_19822575_ChIP-Seq_HepG2_Human1.43758815
21TCF4_18268006_ChIP-ChIP_LS174T_Human1.42826806
22IRF8_22096565_ChIP-ChIP_GC-B_Human1.34587405
23* HNF4A_19822575_ChIP-Seq_HepG2_Human1.33603620
24STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.32911097
25* SOX2_20726797_ChIP-Seq_SW620_Human1.31461504
26STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.27112512
27RXRA_24833708_ChIP-Seq_LIVER_Mouse1.25560325
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.23863884
29FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.20467641
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.19952387
31CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18373854
32IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.11527536
33* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.04922962
34TRIM28_21343339_ChIP-Seq_HEK293_Human1.01878102
35HIF1A_21447827_ChIP-Seq_MCF-7_Human1.00357353
36NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.96688023
37ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95104573
38ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.95102431
39PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94155586
40ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93906830
41PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.91051891
42RARG_19884340_ChIP-ChIP_MEFs_Mouse0.90824561
43SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.89902787
44SOX2_27498859_Chip-Seq_STOMACH_Mouse0.89786604
45TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.86690820
46SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.83926409
47* GATA4_25053715_ChIP-Seq_YYC3_Human0.82340608
48PCGF2_27294783_Chip-Seq_ESCs_Mouse0.82067129
49ESR1_21235772_ChIP-Seq_MCF-7_Human0.81670105
50RARA_24833708_ChIP-Seq_LIVER_Mouse0.81371761
51DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.79267083
52ZNF263_19887448_ChIP-Seq_K562_Human0.78552668
53AUTS2_25519132_ChIP-Seq_293T-REX_Human0.76579827
54* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.76257085
55STAT3_1855785_ChIP-Seq_MESCs_Mouse0.75971036
56KAP1_22055183_ChIP-Seq_ESCs_Mouse0.75801259
57SMAD1_18555785_Chip-Seq_ESCs_Mouse0.75289737
58ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.75119765
59E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.74461294
60PCGF2_27294783_Chip-Seq_NPCs_Mouse0.73793455
61RAC3_21632823_ChIP-Seq_H3396_Human0.73699353
62* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.73687366
63GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.72821408
64CDX2_22108803_ChIP-Seq_LS180_Human0.72412444
65TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.72248708
66BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.71954358
67NFIB_24661679_ChIP-Seq_LUNG_Mouse0.70770907
68NFE2_27457419_Chip-Seq_LIVER_Mouse0.69697483
69GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.69559601
70NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.69161771
71ZFX_18555785_Chip-Seq_ESCs_Mouse0.68663321
72RARB_24833708_ChIP-Seq_LIVER_Mouse0.68630046
73CTNNB1_20460455_ChIP-Seq_HCT116_Human0.68618757
74PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.68225319
75CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.67422922
76MYC_19829295_ChIP-Seq_ESCs_Human0.67031594
77ESRRB_18555785_Chip-Seq_ESCs_Mouse0.66519208
78RAD21_21589869_ChIP-Seq_MESCs_Mouse0.66376241
79ZNF217_24962896_ChIP-Seq_MCF-7_Human0.66336412
80LXR_22292898_ChIP-Seq_THP-1_Human0.66314659
81* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.63092131
82EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.62971614
83RUNX1_27457419_Chip-Seq_LIVER_Mouse0.61578505
84CEBPB_22108803_ChIP-Seq_LS180_Human0.61387500
85EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.61274993
86SUZ12_27294783_Chip-Seq_NPCs_Mouse0.61210338
87SOX2_21211035_ChIP-Seq_LN229_Human0.60695132
88PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.60133674
89FOXH1_21741376_ChIP-Seq_ESCs_Human0.60128943
90PU1_27457419_Chip-Seq_LIVER_Mouse0.59988919
91FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.59814923
92EGR1_19032775_ChIP-ChIP_M12_Human0.58905487
93AR_20517297_ChIP-Seq_VCAP_Human0.58810561
94CTCF_18555785_Chip-Seq_ESCs_Mouse0.58517246
95GATA3_24758297_ChIP-Seq_MCF-7_Human0.57873370
96AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.57831292
97FOXH1_21741376_ChIP-Seq_EPCs_Human0.57466850
98CSB_26484114_Chip-Seq_FIBROBLAST_Human0.57386929
99ESR2_21235772_ChIP-Seq_MCF-7_Human0.56731179
100RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.56021955
101BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.55902597
102ESR1_20079471_ChIP-ChIP_T-47D_Human0.55754249
103KLF4_18555785_Chip-Seq_ESCs_Mouse0.55593492
104RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.55285199
105Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.55212110
106P53_21459846_ChIP-Seq_SAOS-2_Human0.53949759
107* ESET_19884257_ChIP-Seq_ESCs_Mouse0.53944325
108GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.53886051
109GATA1_19941827_ChIP-Seq_MEL_Mouse0.53181536
110SALL4_18804426_ChIP-ChIP_XEN_Mouse0.53135450
111TAF2_19829295_ChIP-Seq_ESCs_Human0.51484882
112SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.48939072
113TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.48824807
114FOXA1_25552417_ChIP-Seq_VCAP_Human0.47910462
115* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.47338367
116* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.47053145
117FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.46421698
118PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.46066512
119ERG_20517297_ChIP-Seq_VCAP_Human0.45931119
120MYC_19915707_ChIP-ChIP_AK7_Human0.45579823
121SRF_21415370_ChIP-Seq_HL-1_Mouse0.45354335
122BCOR_27268052_Chip-Seq_Bcells_Human0.45001168
123CDX2_20551321_ChIP-Seq_CACO-2_Human0.44742547
124LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.44498064
125BRD4_27068464_Chip-Seq_AML-cells_Mouse0.43582041
126PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.42437837
127* CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.42338152
128GATA1_22383799_ChIP-Seq_G1ME_Mouse0.42169915
129STAT1_17558387_ChIP-Seq_HELA_Human0.41708692
130CBP_21632823_ChIP-Seq_H3396_Human0.41101848
131STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.41101277
132IRF1_19129219_ChIP-ChIP_H3396_Human0.40957965
133TET1_21451524_ChIP-Seq_MESCs_Mouse0.40815010
134NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.40567934
135NRF2_20460467_ChIP-Seq_MEFs_Mouse0.40567934
136CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.40322203
137CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.39944461
138SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.39914357
139SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.39417967
140GATA2_19941826_ChIP-Seq_K562_Human0.39151450
141NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.39010123
142* GATA6_25053715_ChIP-Seq_YYC3_Human0.38934966
143ELF1_17652178_ChIP-ChIP_JURKAT_Human0.38778640
144SPI1_26923725_Chip-Seq_HPCs_Mouse0.38316495

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.20636951
2MP0005360_urolithiasis7.25842363
3MP0005085_abnormal_gallbladder_physiolo6.40374069
4* MP0005365_abnormal_bile_salt6.21615835
5MP0008875_abnormal_xenobiotic_pharmacok4.87437141
6MP0003806_abnormal_nucleotide_metabolis4.34164585
7MP0003252_abnormal_bile_duct3.82288217
8MP0003122_maternal_imprinting3.61752248
9MP0005083_abnormal_biliary_tract3.48023974
10* MP0010329_abnormal_lipoprotein_level3.40446677
11MP0009840_abnormal_foam_cell3.31988434
12* MP0001666_abnormal_nutrient_absorption2.85385145
13MP0005332_abnormal_amino_acid2.75506969
14MP0003195_calcinosis2.73841303
15MP0003191_abnormal_cellular_cholesterol2.33303286
16* MP0000609_abnormal_liver_physiology2.11317293
17* MP0002118_abnormal_lipid_homeostasis2.10501647
18MP0003868_abnormal_feces_composition2.00697523
19MP0004019_abnormal_vitamin_homeostasis1.90422563
20* MP0005319_abnormal_enzyme/_coenzyme1.87648014
21MP0002138_abnormal_hepatobiliary_system1.87612400
22MP0003172_abnormal_lysosome_physiology1.86733756
23MP0003123_paternal_imprinting1.86514012
24MP0001764_abnormal_homeostasis1.77187356
25MP0009780_abnormal_chondrocyte_physiolo1.75710712
26MP0000566_synostosis1.67467906
27MP0009697_abnormal_copulation1.67016755
28MP0005379_endocrine/exocrine_gland_phen1.65274680
29MP0005584_abnormal_enzyme/coenzyme_acti1.60935574
30MP0002089_abnormal_postnatal_growth/wei1.55892730
31MP0002132_abnormal_respiratory_system1.53511138
32MP0005451_abnormal_body_composition1.45665161
33MP0003186_abnormal_redox_activity1.41476040
34MP0002909_abnormal_adrenal_gland1.38208425
35MP0009643_abnormal_urine_homeostasis1.28867751
36MP0001915_intracranial_hemorrhage1.26986656
37MP0003011_delayed_dark_adaptation1.22228313
38MP0000598_abnormal_liver_morphology1.21213869
39MP0003656_abnormal_erythrocyte_physiolo1.20142918
40MP0006036_abnormal_mitochondrial_physio1.16761892
41MP0005220_abnormal_exocrine_pancreas1.15675857
42MP0009763_increased_sensitivity_to1.05812412
43MP0009764_decreased_sensitivity_to1.04091606
44MP0010386_abnormal_urinary_bladder1.03158681
45MP0005084_abnormal_gallbladder_morpholo1.03143009
46MP0003705_abnormal_hypodermis_morpholog1.00084312
47MP0005636_abnormal_mineral_homeostasis0.98289492
48MP0010368_abnormal_lymphatic_system0.97478633
49MP0003879_abnormal_hair_cell0.97112918
50MP0005409_darkened_coat_color0.96484676
51MP0003121_genomic_imprinting0.96214497
52MP0000604_amyloidosis0.96090754
53* MP0008469_abnormal_protein_level0.95980728
54* MP0009642_abnormal_blood_homeostasis0.90031741
55MP0000003_abnormal_adipose_tissue0.89719903
56MP0002837_dystrophic_cardiac_calcinosis0.87524184
57MP0005376_homeostasis/metabolism_phenot0.85007746
58MP0002078_abnormal_glucose_homeostasis0.84377540
59MP0000013_abnormal_adipose_tissue0.84173573
60* MP0005647_abnormal_sex_gland0.84007174
61MP0005167_abnormal_blood-brain_barrier0.82255465
62MP0005408_hypopigmentation0.81293436
63MP0009765_abnormal_xenobiotic_induced0.78101833
64MP0005266_abnormal_metabolism0.77712855
65MP0002693_abnormal_pancreas_physiology0.77589053
66MP0004130_abnormal_muscle_cell0.76323061
67MP0003183_abnormal_peptide_metabolism0.75140671
68MP0006035_abnormal_mitochondrial_morpho0.75074098
69MP0002938_white_spotting0.74811776
70MP0004043_abnormal_pH_regulation0.72641048
71MP0005670_abnormal_white_adipose0.72467875
72MP0005646_abnormal_pituitary_gland0.71388367
73MP0002163_abnormal_gland_morphology0.71023666
74MP0002971_abnormal_brown_adipose0.70842459
75MP0005334_abnormal_fat_pad0.70540908
76MP0002254_reproductive_system_inflammat0.70531272
77MP0005535_abnormal_body_temperature0.69384655
78MP0002876_abnormal_thyroid_physiology0.69135610
79MP0006054_spinal_hemorrhage0.68033785
80MP0003943_abnormal_hepatobiliary_system0.63375658
81MP0000639_abnormal_adrenal_gland0.61581403
82MP0010234_abnormal_vibrissa_follicle0.59948906
83MP0005448_abnormal_energy_balance0.59701927
84MP0005464_abnormal_platelet_physiology0.58511237
85MP0001756_abnormal_urination0.57962785
86MP0003638_abnormal_response/metabolism_0.57224925
87MP0002168_other_aberrant_phenotype0.54056934
88MP0003690_abnormal_glial_cell0.53407841
89MP0001270_distended_abdomen0.53251954
90MP0003329_amyloid_beta_deposits0.52014433
91MP0009053_abnormal_anal_canal0.51387402
92MP0001661_extended_life_span0.50131476
93MP0001765_abnormal_ion_homeostasis0.49227478
94MP0003724_increased_susceptibility_to0.48799547
95MP0008873_increased_physiological_sensi0.46307600
96MP0002928_abnormal_bile_duct0.45739444
97MP0003436_decreased_susceptibility_to0.45524183
98MP0000371_diluted_coat_color0.45388479
99MP0008874_decreased_physiological_sensi0.45175083
100MP0004270_analgesia0.44163567
101MP0002136_abnormal_kidney_physiology0.43826740
102* MP0003953_abnormal_hormone_level0.43089894
103MP0002822_catalepsy0.42290055
104MP0005551_abnormal_eye_electrophysiolog0.40989903
105MP0001853_heart_inflammation0.40766796
106MP0004782_abnormal_surfactant_physiolog0.40275558
107MP0005330_cardiomyopathy0.40232039
108MP0005257_abnormal_intraocular_pressure0.39853425
109MP0005166_decreased_susceptibility_to0.38434905
110MP0000230_abnormal_systemic_arterial0.38389084
111MP0003075_altered_response_to0.37507345
112MP0003633_abnormal_nervous_system0.37481962
113MP0005410_abnormal_fertilization0.37277758
114MP0005666_abnormal_adipose_tissue0.37190973
115MP0001845_abnormal_inflammatory_respons0.36584058
116MP0004264_abnormal_extraembryonic_tissu0.36046810
117MP0003718_maternal_effect0.35694881
118MP0002970_abnormal_white_adipose0.35622745
119MP0004381_abnormal_hair_follicle0.35372140
120MP0002269_muscular_atrophy0.35330803
121MP0005164_abnormal_response_to0.34990764
122MP0005395_other_phenotype0.34932530
123MP0003283_abnormal_digestive_organ0.34902860
124MP0009672_abnormal_birth_weight0.34705950
125MP0008872_abnormal_physiological_respon0.34368162
126MP0009384_cardiac_valve_regurgitation0.34164677
127MP0003959_abnormal_lean_body0.33906728
128MP0000249_abnormal_blood_vessel0.33309399
129MP0009115_abnormal_fat_cell0.31158590
130MP0005058_abnormal_lysosome_morphology0.29862183
131MP0001944_abnormal_pancreas_morphology0.29786874
132MP0003221_abnormal_cardiomyocyte_apopto0.29080343
133MP0000579_abnormal_nail_morphology0.29039622
134MP0005165_increased_susceptibility_to0.28576890
135MP0006082_CNS_inflammation0.27429053
136MP0002796_impaired_skin_barrier0.25797316
137MP0001243_abnormal_dermal_layer0.24083021

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.23883971
2Intrahepatic cholestasis (HP:0001406)7.04560464
3Deep venous thrombosis (HP:0002625)6.92729606
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.34935698
5Prolonged partial thromboplastin time (HP:0003645)6.29553806
6Hypobetalipoproteinemia (HP:0003563)6.24989714
7Xanthomatosis (HP:0000991)5.88878329
8Hyperlipoproteinemia (HP:0010980)5.35923396
9Complement deficiency (HP:0004431)5.05704683
10Hypolipoproteinemia (HP:0010981)4.60638550
11Hyperammonemia (HP:0001987)4.60465192
12Joint hemorrhage (HP:0005261)4.59560255
13Ketosis (HP:0001946)4.44329858
14Hyperglycinemia (HP:0002154)4.41064428
15Abnormality of the common coagulation pathway (HP:0010990)4.35863556
16Hypoglycemic coma (HP:0001325)4.35623497
17Fat malabsorption (HP:0002630)4.25414880
18Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.21081508
19Abnormality of methionine metabolism (HP:0010901)4.11238827
20Epidermoid cyst (HP:0200040)4.10949633
21Abnormality of sulfur amino acid metabolism (HP:0004339)4.06444012
22Abnormality of aspartate family amino acid metabolism (HP:0010899)3.95090091
23Hyperglycinuria (HP:0003108)3.94518158
24Hypoalphalipoproteinemia (HP:0003233)3.94443063
25Abnormality of the intrinsic pathway (HP:0010989)3.93053403
26Abnormality of serine family amino acid metabolism (HP:0010894)3.92560564
27Abnormality of glycine metabolism (HP:0010895)3.92560564
28Abnormality of glutamine family amino acid metabolism (HP:0010902)3.74457320
29Abnormality of fatty-acid metabolism (HP:0004359)3.71950826
30Abnormality of complement system (HP:0005339)3.70221196
31Abnormality of pyrimidine metabolism (HP:0004353)3.69881323
32Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.61853064
33Conjugated hyperbilirubinemia (HP:0002908)3.54840861
34Steatorrhea (HP:0002570)3.40731899
35Hyperbilirubinemia (HP:0002904)3.40652594
36Hypercholesterolemia (HP:0003124)3.38674308
37Ketoacidosis (HP:0001993)3.32768353
38Delayed CNS myelination (HP:0002188)3.13688319
39Abnormality of serum amino acid levels (HP:0003112)3.09235522
40Dicarboxylic aciduria (HP:0003215)2.99957244
41Abnormality of dicarboxylic acid metabolism (HP:0010995)2.99957244
42Abnormality of nucleobase metabolism (HP:0010932)2.99187128
43Metabolic acidosis (HP:0001942)2.88957745
44Purpura (HP:0000979)2.87282669
45Spontaneous abortion (HP:0005268)2.80271819
46Hepatocellular carcinoma (HP:0001402)2.78331747
47Lethargy (HP:0001254)2.75395912
48Cerebral edema (HP:0002181)2.72001471
49Hypochromic microcytic anemia (HP:0004840)2.71992541
50Myocardial infarction (HP:0001658)2.70675574
51Hydroxyprolinuria (HP:0003080)2.64901662
52Abnormality of proline metabolism (HP:0010907)2.64901662
53Skin nodule (HP:0200036)2.64704343
54Abnormality of purine metabolism (HP:0004352)2.63840030
55Systemic lupus erythematosus (HP:0002725)2.60716582
56Gout (HP:0001997)2.60133772
57Hypoglycemic seizures (HP:0002173)2.58229203
58Generalized aminoaciduria (HP:0002909)2.51345071
59Hypophosphatemic rickets (HP:0004912)2.49104944
60Nephritis (HP:0000123)2.48940376
61Vascular calcification (HP:0004934)2.46829387
62Arthropathy (HP:0003040)2.46489192
63Pancreatic islet-cell hyperplasia (HP:0004510)2.45341807
64Abnormality of carpal bone ossification (HP:0006257)2.45341248
65Late onset (HP:0003584)2.44252878
66Abnormal gallbladder morphology (HP:0012437)2.43606471
67Acanthocytosis (HP:0001927)2.38599535
68Cholelithiasis (HP:0001081)2.38584400
69Facial shape deformation (HP:0011334)2.38132200
70Potter facies (HP:0002009)2.38132200
71Asymmetry of the thorax (HP:0001555)2.37103339
72Hypothermia (HP:0002045)2.34573067
73Spastic diplegia (HP:0001264)2.34200595
74Mitral stenosis (HP:0001718)2.34133441
75Neonatal onset (HP:0003623)2.32082070
76Small epiphyses (HP:0010585)2.31914609
77Recurrent gram-negative bacterial infections (HP:0005420)2.27675736
78Amyloidosis (HP:0011034)2.24854880
79Hyperinsulinemic hypoglycemia (HP:0000825)2.24450937
80Pancreatitis (HP:0001733)2.23258759
81Vomiting (HP:0002013)2.21637707
82Cholecystitis (HP:0001082)2.20217065
83Abnormal gallbladder physiology (HP:0012438)2.20217065
84Broad alveolar ridges (HP:0000187)2.19492776
85Irritability (HP:0000737)2.19257373
86Rickets (HP:0002748)2.18377325
87Glomerulonephritis (HP:0000099)2.18230286
88Cardiovascular calcification (HP:0011915)2.17253870
89Gingival bleeding (HP:0000225)2.17120138
90Brushfield spots (HP:0001088)2.16992008
91Opisthotonus (HP:0002179)2.16801803
92Increased serum pyruvate (HP:0003542)2.16602361
93Malnutrition (HP:0004395)2.14324798
94Abnormal tarsal ossification (HP:0008369)2.13700314
95Vaginal fistula (HP:0004320)2.10343798
96Renal cortical cysts (HP:0000803)2.08141540
97Thrombophlebitis (HP:0004418)2.07469581
98Esophageal varix (HP:0002040)2.07028559
99Menorrhagia (HP:0000132)2.03550050
100Sensorimotor neuropathy (HP:0007141)1.99853262
101Abnormality of the nasal septum (HP:0000419)1.98925378
102Enlarged kidneys (HP:0000105)1.96606059
103Abnormality of iron homeostasis (HP:0011031)1.96325719
104Poikilocytosis (HP:0004447)1.95785997
105Abnormality of the gallbladder (HP:0005264)1.95524681
106Proximal tubulopathy (HP:0000114)1.95408401
107Abnormality of glycolysis (HP:0004366)1.94419402
108Abnormality of transition element cation homeostasis (HP:0011030)1.93397167
109Mucopolysacchariduria (HP:0008155)1.91060891
110Urinary glycosaminoglycan excretion (HP:0003541)1.91060891
111Elevated hepatic transaminases (HP:0002910)1.89595270
112Abnormality of urine glucose concentration (HP:0011016)1.88394943
113Glycosuria (HP:0003076)1.88394943
114Widely patent fontanelles and sutures (HP:0004492)1.87472838
115Hemorrhage of the eye (HP:0011885)1.86253022
116Abnormal cartilage morphology (HP:0002763)1.86244451
117Pulmonary embolism (HP:0002204)1.84538549
118Abnormality of endocrine pancreas physiology (HP:0012093)1.83872765
119Abnormality of the pancreatic islet cells (HP:0006476)1.83872765
120Hepatoblastoma (HP:0002884)1.83667742
121Abnormal hand bone ossification (HP:0010660)1.81282489
122Nausea (HP:0002018)1.81072029
123Hepatic necrosis (HP:0002605)1.80061181
124Hyperglycemia (HP:0003074)1.78710964
125Abnormality of the vitreous humor (HP:0004327)1.77213075
126Osteomalacia (HP:0002749)1.76840652
127Abnormality of mucopolysaccharide metabolism (HP:0011020)1.75027468
128Abnormality of polysaccharide metabolism (HP:0011012)1.75027468
129Abnormality of glycosaminoglycan metabolism (HP:0004371)1.75027468
130Ragged-red muscle fibers (HP:0003200)1.73527473
131Hypoplasia of the capital femoral epiphysis (HP:0003090)1.70085716
132Acute hepatic failure (HP:0006554)1.69922796
133Abnormality of the Achilles tendon (HP:0005109)1.69787381
134Abnormal enzyme/coenzyme activity (HP:0012379)1.69359680
135Abnormality of vitamin metabolism (HP:0100508)1.68770232
136Impaired pain sensation (HP:0007328)1.66702532
137Abnormality of pain sensation (HP:0010832)1.66702532
138Bifid scrotum (HP:0000048)1.65507058

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK8.36783267
2FGFR35.13985075
3ERN14.75872207
4WNK44.21228965
5SIK13.94698690
6FGFR43.92507404
7TAOK33.07475662
8LMTK23.00739371
9PKN22.75992406
10FLT32.56102732
11INSRR2.53327655
12ERBB42.24460448
13MAP2K42.09024286
14AKT32.04420551
15TRIB32.04335373
16STK241.90517864
17PIK3CG1.85093106
18NTRK31.78745713
19MAPK111.77092821
20MAP2K31.74375375
21TYK21.71064258
22FGFR11.68211187
23CDK121.64100402
24MST1R1.61727050
25KDR1.54587685
26ABL21.54141364
27TYRO31.50037303
28EPHA21.39540590
29WNK11.38621684
30MAP3K21.34693612
31PINK11.30607408
32PDGFRA1.30025235
33NEK91.26016638
34PTK61.24378703
35DAPK21.23723105
36TBK11.20670380
37TIE11.18878371
38SIK21.12332223
39FRK1.07232727
40STK161.07058963
41MAP2K61.06614443
42JAK21.06335948
43MAP4K21.06139691
44IRAK31.05799006
45MAP3K61.05466952
46MAP3K71.00658530
47MAPK151.00439687
48PRKAA20.98576512
49STK390.97738366
50MAPK40.94503256
51PRKG20.94027958
52MYLK0.93308091
53MAP3K110.90937554
54SGK4940.88055802
55SGK2230.88055802
56SGK10.87445646
57MAP3K30.85734806
58MAPK120.84033868
59GRK60.82963182
60LATS10.81914889
61NLK0.80752311
62FER0.79409853
63RIPK10.75935589
64JAK10.75315091
65MST40.74463210
66ERBB20.74460452
67EIF2AK10.73509970
68SGK30.72421343
69TGFBR20.72387819
70PIK3CA0.71150151
71PHKG10.71013088
72PHKG20.71013088
73KIT0.70149020
74DDR20.69709642
75SGK20.68526327
76PRKACG0.68157006
77MAP3K90.67904229
78CSNK1E0.67876836
79MAP3K140.67792701
80CDC42BPA0.67196351
81DYRK1B0.66479001
82MAP3K50.64967793
83MAP3K100.64082591
84PRKG10.63446718
85CAMK2G0.63145708
86CSF1R0.63099504
87PRKCZ0.62096379
88OBSCN0.62084577
89PRKAA10.59300341
90PRKCG0.58746405
91ZAP700.58362888
92NME20.58283854
93FGFR20.57415366
94PDK20.57274269
95PDK40.56279030
96PDK30.56279030
97IKBKE0.55692718
98CDK60.51922011
99EPHB10.51674398
100TAOK10.51254563
101CDK40.49459438
102CSK0.48661384
103RPS6KB10.48260816
104MAP3K10.47203000
105HIPK20.46608391
106EEF2K0.46586825
107EPHA40.46546662
108STK38L0.45356215
109CSNK1D0.44518845
110BCR0.43586084
111GSK3A0.42969872
112CAMK1D0.42813941
113CAMK40.42133604
114PDPK10.42121139
115CAMK2D0.40314473
116PRKACA0.39827115
117BTK0.39442993
118ACVR1B0.38539953
119PRKCQ0.38355991
120PTK20.38065163
121MAP4K10.37747729
122FGR0.37743885
123MAPKAPK30.36044326
124STK380.35822239
125IGF1R0.35581010
126CSNK1G10.35193563
127EPHA30.34659374
128EIF2AK30.34599653
129MAP2K20.34212952
130PRKCE0.34037330
131MAPK70.33657140
132NEK10.32890462
133TAOK20.32724612
134RPS6KA30.31755733
135MET0.31431584
136SRC0.31314755
137CDK70.30939735
138PDK10.30314696
139CSNK2A20.29780783
140CAMK1G0.29760506
141RET0.29691415
142MAP2K10.29627026
143TEC0.28604128
144MAP3K130.28460966
145TRPM70.27797704
146GRK10.27760178
147STK30.27494443
148CSNK1G30.27098801
149PRKACB0.25801783
150MTOR0.23523591
151EGFR0.22576612
152ICK0.22275156
153TGFBR10.21416998
154ITK0.20920669
155PRKCA0.20153482
156TTN0.19976862

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.47349090
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.29932392
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.24122836
4Nitrogen metabolism_Homo sapiens_hsa009103.14523537
5Arginine biosynthesis_Homo sapiens_hsa002202.90012001
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.68600841
7Tryptophan metabolism_Homo sapiens_hsa003802.66906518
8Complement and coagulation cascades_Homo sapiens_hsa046102.62901025
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.61478980
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.60120580
11Fatty acid degradation_Homo sapiens_hsa000712.57329051
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.52849235
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.19142997
14Peroxisome_Homo sapiens_hsa041462.13512767
15Butanoate metabolism_Homo sapiens_hsa006502.10205867
16Propanoate metabolism_Homo sapiens_hsa006402.10192209
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.08975936
18Chemical carcinogenesis_Homo sapiens_hsa052041.91285641
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.88830980
20Fatty acid metabolism_Homo sapiens_hsa012121.83993882
21Histidine metabolism_Homo sapiens_hsa003401.83875933
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.82751201
23PPAR signaling pathway_Homo sapiens_hsa033201.81294943
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.78636010
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.75785238
26beta-Alanine metabolism_Homo sapiens_hsa004101.73464246
27Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.68324176
28Caffeine metabolism_Homo sapiens_hsa002321.67149832
29Staphylococcus aureus infection_Homo sapiens_hsa051501.62308975
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.61660899
31Retinol metabolism_Homo sapiens_hsa008301.60063021
32Selenocompound metabolism_Homo sapiens_hsa004501.59823638
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.59590628
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56856583
35Folate biosynthesis_Homo sapiens_hsa007901.52083954
36Phenylalanine metabolism_Homo sapiens_hsa003601.48561152
37Pyruvate metabolism_Homo sapiens_hsa006201.45364207
38Fat digestion and absorption_Homo sapiens_hsa049751.41756236
39Fatty acid elongation_Homo sapiens_hsa000621.39676715
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.39072572
41Tyrosine metabolism_Homo sapiens_hsa003501.38200488
42Sulfur metabolism_Homo sapiens_hsa009201.37006049
43Starch and sucrose metabolism_Homo sapiens_hsa005001.34599165
44Biosynthesis of amino acids_Homo sapiens_hsa012301.30984630
45* Bile secretion_Homo sapiens_hsa049761.30386630
46Carbon metabolism_Homo sapiens_hsa012001.28045113
47Other glycan degradation_Homo sapiens_hsa005111.26247738
48Cyanoamino acid metabolism_Homo sapiens_hsa004601.14257196
49Maturity onset diabetes of the young_Homo sapiens_hsa049501.11798340
50ABC transporters_Homo sapiens_hsa020101.11286063
51Sulfur relay system_Homo sapiens_hsa041221.11062295
52Steroid biosynthesis_Homo sapiens_hsa001001.08016691
53Arginine and proline metabolism_Homo sapiens_hsa003301.02850876
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.02061319
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.96230498
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.94055742
57Vitamin B6 metabolism_Homo sapiens_hsa007500.89910162
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.88621624
59Vitamin digestion and absorption_Homo sapiens_hsa049770.88091096
60One carbon pool by folate_Homo sapiens_hsa006700.87331833
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79768245
62Lysine degradation_Homo sapiens_hsa003100.78291505
63Glutathione metabolism_Homo sapiens_hsa004800.75731116
64Glycerolipid metabolism_Homo sapiens_hsa005610.73932836
65Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.72434112
66Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.72244785
67Pentose phosphate pathway_Homo sapiens_hsa000300.66491114
68Metabolic pathways_Homo sapiens_hsa011000.52907735
69N-Glycan biosynthesis_Homo sapiens_hsa005100.50842157
70Thyroid hormone synthesis_Homo sapiens_hsa049180.47968913
71Sphingolipid metabolism_Homo sapiens_hsa006000.44998172
72Fatty acid biosynthesis_Homo sapiens_hsa000610.43651514
73Galactose metabolism_Homo sapiens_hsa000520.41379720
74Mineral absorption_Homo sapiens_hsa049780.38144903
75Fructose and mannose metabolism_Homo sapiens_hsa000510.36441997
76Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.35823787
77Prion diseases_Homo sapiens_hsa050200.30067430
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.28378380
79Pertussis_Homo sapiens_hsa051330.27365200
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26868068
81Circadian rhythm_Homo sapiens_hsa047100.25752779
82Linoleic acid metabolism_Homo sapiens_hsa005910.23354062
83Ether lipid metabolism_Homo sapiens_hsa005650.22051782
84Insulin resistance_Homo sapiens_hsa049310.20507529
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.18880511
86Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.16485707
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.08588875
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.08533123
89Glucagon signaling pathway_Homo sapiens_hsa049220.07751030
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.06866758
91Insulin secretion_Homo sapiens_hsa049110.03430104
92Vibrio cholerae infection_Homo sapiens_hsa051100.02873156
93Alzheimers disease_Homo sapiens_hsa05010-0.1904087
94African trypanosomiasis_Homo sapiens_hsa05143-0.1876173
95Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1776577
96Pancreatic secretion_Homo sapiens_hsa04972-0.1616308
97Pyrimidine metabolism_Homo sapiens_hsa00240-0.1503917
98Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1438746
99Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1381109
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1339670
101Oxidative phosphorylation_Homo sapiens_hsa00190-0.1333985
102Regulation of autophagy_Homo sapiens_hsa04140-0.1294070
103Parkinsons disease_Homo sapiens_hsa05012-0.1292672
104Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1246055
105Protein digestion and absorption_Homo sapiens_hsa04974-0.1203836
106Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1194427
107Insulin signaling pathway_Homo sapiens_hsa04910-0.1088133
108Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1069523
109Protein export_Homo sapiens_hsa03060-0.0816539
110Renin-angiotensin system_Homo sapiens_hsa04614-0.0797467
111Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0552795
112Lysosome_Homo sapiens_hsa04142-0.0200347
113AMPK signaling pathway_Homo sapiens_hsa04152-0.0087584

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