NPY

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to ethanol (GO:0048149)9.83517811
2phenol-containing compound catabolic process (GO:0019336)8.33118945
3aggressive behavior (GO:0002118)8.23249525
4exogenous drug catabolic process (GO:0042738)8.05964471
5neurotransmitter biosynthetic process (GO:0042136)8.05105168
6positive regulation of synaptic transmission, dopaminergic (GO:0032226)7.40158845
7succinate metabolic process (GO:0006105)6.60397742
8drug catabolic process (GO:0042737)6.35473477
9regulation of neurotransmitter uptake (GO:0051580)6.24868170
10synaptic transmission, dopaminergic (GO:0001963)6.16892103
11behavioral response to nicotine (GO:0035095)6.05417494
12neurotransmitter metabolic process (GO:0042133)5.84106709
13regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.71821099
14peptidyl-cysteine modification (GO:0018198)5.46562502
15regulation of dopamine uptake involved in synaptic transmission (GO:0051584)5.42563698
16regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)5.42563698
17neurotransmitter secretion (GO:0007269)5.22579742
18neurotransmitter catabolic process (GO:0042135)5.10115150
19sympathetic nervous system development (GO:0048485)5.05277113
20insulin secretion (GO:0030073)4.89925206
21arginine catabolic process (GO:0006527)4.89804622
22synaptic vesicle exocytosis (GO:0016079)4.83851617
23energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.79252389
24ATP hydrolysis coupled proton transport (GO:0015991)4.79252389
25negative regulation of neurotransmitter transport (GO:0051589)4.77602256
26negative regulation of calcium ion transport into cytosol (GO:0010523)4.59215965
27negative regulation of cytosolic calcium ion concentration (GO:0051481)4.57194254
28endocrine pancreas development (GO:0031018)4.41709034
29negative regulation of hormone biosynthetic process (GO:0032353)4.37407213
30negative regulation of synaptic transmission, GABAergic (GO:0032229)4.35472688
31maternal behavior (GO:0042711)4.34383484
32positive regulation of action potential (GO:0045760)4.26612646
33regulation of type B pancreatic cell apoptotic process (GO:2000674)4.26552647
34protein-cofactor linkage (GO:0018065)4.25803772
35catecholamine transport (GO:0051937)4.25574227
36startle response (GO:0001964)4.25251630
37glandular epithelial cell differentiation (GO:0002067)4.21947395
38glycerophospholipid catabolic process (GO:0046475)4.18953142
39gamma-aminobutyric acid transport (GO:0015812)4.16566946
40dicarboxylic acid catabolic process (GO:0043649)4.16217081
41regulation of glutamate receptor signaling pathway (GO:1900449)4.16182978
42glutamine family amino acid catabolic process (GO:0009065)4.16168039
43regulation of neurotransmitter levels (GO:0001505)4.12899725
44positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.11500253
45artery smooth muscle contraction (GO:0014824)4.10798982
46cellular response to ammonium ion (GO:0071242)4.08891229
47phagosome maturation (GO:0090382)4.05733262
48vascular smooth muscle contraction (GO:0014829)4.01434024
49transferrin transport (GO:0033572)3.99184007
50neurotransmitter transport (GO:0006836)3.98063589
51type B pancreatic cell development (GO:0003323)3.94924420
52tonic smooth muscle contraction (GO:0014820)3.93748678
53peptide hormone processing (GO:0016486)3.86629819
54peptide hormone secretion (GO:0030072)3.85773727
55positive regulation of neurotransmitter transport (GO:0051590)3.84678640
56negative regulation of receptor activity (GO:2000272)3.82828556
57regulation of synaptic transmission, dopaminergic (GO:0032225)3.81968317
58cellular zinc ion homeostasis (GO:0006882)3.79961015
59response to cocaine (GO:0042220)3.79080996
60dopamine metabolic process (GO:0042417)3.76653257
61parental behavior (GO:0060746)3.76049254
62peptide secretion (GO:0002790)3.73995653
63regulation of neurotransmitter transport (GO:0051588)3.73696264
64trivalent inorganic cation transport (GO:0072512)3.73124816
65ferric iron transport (GO:0015682)3.73124816
66synaptic transmission, cholinergic (GO:0007271)3.72045493
67G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.67509276
68regulation of short-term neuronal synaptic plasticity (GO:0048172)3.64604859
69astrocyte differentiation (GO:0048708)3.64330336
70neuronal action potential propagation (GO:0019227)3.61082840
71positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.60191454
72negative regulation of hormone metabolic process (GO:0032351)3.59952979
73presynaptic membrane assembly (GO:0097105)3.58826375
74serotonin metabolic process (GO:0042428)3.58190261
75norepinephrine metabolic process (GO:0042415)3.57361317
76inositol phosphate catabolic process (GO:0071545)3.55471733
77zinc ion homeostasis (GO:0055069)3.55028967
78nitric oxide mediated signal transduction (GO:0007263)3.54846730
79response to pheromone (GO:0019236)3.52145468
80positive regulation of amine transport (GO:0051954)3.50786403
81neuron-neuron synaptic transmission (GO:0007270)3.50116575
82catecholamine biosynthetic process (GO:0042423)3.49915959
83catechol-containing compound biosynthetic process (GO:0009713)3.49915959
84positive regulation of guanylate cyclase activity (GO:0031284)3.49592846
85regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.48211202
86glutamate secretion (GO:0014047)3.47703489
87regulation of glucocorticoid metabolic process (GO:0031943)3.45399149
88regulation of synaptic vesicle exocytosis (GO:2000300)3.45305618
89positive regulation of glycolytic process (GO:0045821)3.44849294
90calcium ion import (GO:0070509)3.43072219
91neuromuscular synaptic transmission (GO:0007274)3.41731686
92neuron cell-cell adhesion (GO:0007158)3.39616405
93kidney morphogenesis (GO:0060993)3.36703066
94oxygen transport (GO:0015671)3.34943507
95positive regulation of synaptic transmission, GABAergic (GO:0032230)3.32045144
96regulation of hexokinase activity (GO:1903299)3.30181792
97regulation of glucokinase activity (GO:0033131)3.30181792
98L-alpha-amino acid transmembrane transport (GO:1902475)3.30168002
99sequestering of metal ion (GO:0051238)3.30095949
100positive regulation of insulin secretion (GO:0032024)3.29905973
101signal peptide processing (GO:0006465)3.26966054
102lactate metabolic process (GO:0006089)3.26718134
103neuromuscular process controlling posture (GO:0050884)3.26440320
104response to pain (GO:0048265)3.26259383
105negative regulation of microtubule polymerization (GO:0031115)3.26120305
106detection of calcium ion (GO:0005513)3.25748596
107regulation of vesicle fusion (GO:0031338)3.22430864
108positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-3.22262176
109vocalization behavior (GO:0071625)3.14940556
110polyol catabolic process (GO:0046174)3.14448703
111regulation of guanylate cyclase activity (GO:0031282)3.13822367
112positive regulation of peptide hormone secretion (GO:0090277)3.13548178
113cell migration in hindbrain (GO:0021535)3.12069333
114adenosine metabolic process (GO:0046085)3.11607970
115cellular ketone body metabolic process (GO:0046950)3.10997574
116positive regulation of sodium ion transmembrane transport (GO:1902307)3.07921236
117glandular epithelial cell development (GO:0002068)3.07435332
118peptide transport (GO:0015833)3.07077807
119positive regulation of peptide secretion (GO:0002793)3.04258669
120hormone secretion (GO:0046879)3.02612233
121proline transport (GO:0015824)3.01146739
122positive regulation of macroautophagy (GO:0016239)2.98999018
123epithelial cell fate commitment (GO:0072148)2.98191380
124zinc ion transmembrane transport (GO:0071577)2.96433663
125regulation of neurotransmitter secretion (GO:0046928)2.95699565
126primary amino compound metabolic process (GO:1901160)2.94219578
127regulation of energy homeostasis (GO:2000505)2.93609233
128response to amphetamine (GO:0001975)2.93336750
129membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.93221800
130mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.92643108
131presynaptic membrane organization (GO:0097090)2.90908468
132regulation of synaptic vesicle transport (GO:1902803)2.90890750
133signal release (GO:0023061)2.90143862
134multi-organism behavior (GO:0051705)2.89714305
135positive regulation of vesicle fusion (GO:0031340)2.89671655
136regulation of uterine smooth muscle contraction (GO:0070472)2.88045141
137regulation of insulin secretion (GO:0050796)2.87949123
138positive regulation of glycogen biosynthetic process (GO:0045725)2.85986319
139protein import into peroxisome matrix (GO:0016558)2.85941748
140synaptic vesicle maturation (GO:0016188)2.85855647
141positive regulation of uterine smooth muscle contraction (GO:0070474)2.85094854
142regulation of action potential (GO:0098900)2.84218622
143activation of protein kinase A activity (GO:0034199)2.83949192
144hormone transport (GO:0009914)2.83820043
145positive regulation of neurotransmitter secretion (GO:0001956)2.83305807
146protein polyglutamylation (GO:0018095)2.83104424
147ATP synthesis coupled proton transport (GO:0015986)2.80772722
148energy coupled proton transport, down electrochemical gradient (GO:0015985)2.80772722
149cardiac left ventricle morphogenesis (GO:0003214)2.80181959
150gamma-aminobutyric acid signaling pathway (GO:0007214)2.80148441
151arginine metabolic process (GO:0006525)2.78943367
152mating behavior (GO:0007617)2.77455868
153mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.77184702
154* synaptic transmission (GO:0007268)2.76767051
155intra-Golgi vesicle-mediated transport (GO:0006891)2.76564672
156phosphorylated carbohydrate dephosphorylation (GO:0046838)2.76264242
157inositol phosphate dephosphorylation (GO:0046855)2.76264242
158calcium-mediated signaling using intracellular calcium source (GO:0035584)2.76066262
159regulation of synapse structural plasticity (GO:0051823)2.74220764
160ketone body metabolic process (GO:1902224)2.73832808
161regulation of synaptic transmission, GABAergic (GO:0032228)2.73620707
162regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.73366488
163response to lipoprotein particle (GO:0055094)2.72476838
164columnar/cuboidal epithelial cell development (GO:0002066)2.71140018
165righting reflex (GO:0060013)2.69278894
166negative regulation of dendrite development (GO:2000171)2.68519239
167positive regulation of hormone secretion (GO:0046887)2.67925068
168synaptic vesicle docking involved in exocytosis (GO:0016081)2.66589417
169regulation of peptide hormone secretion (GO:0090276)2.66006057
170regulation of steroid hormone biosynthetic process (GO:0090030)2.65923501
171postsynaptic membrane organization (GO:0001941)2.65793376
172amide transport (GO:0042886)2.65512568
173toxin transport (GO:1901998)2.63970663
174response to dietary excess (GO:0002021)2.63949213
175fatty acid homeostasis (GO:0055089)2.62925227
176synapse assembly (GO:0007416)2.62787226
177nucleoside diphosphate catabolic process (GO:0009134)2.61492458
178regulation of peptide secretion (GO:0002791)2.60288583
179dendritic spine morphogenesis (GO:0060997)2.59466992
180response to gravity (GO:0009629)2.59125801
181zinc ion transport (GO:0006829)2.58261218
182regulation of hormone secretion (GO:0046883)2.55694288
183calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.54583307
184eye photoreceptor cell differentiation (GO:0001754)2.54519864
185photoreceptor cell differentiation (GO:0046530)2.54519864
186ovulation from ovarian follicle (GO:0001542)2.54375443
187pancreas development (GO:0031016)2.54059043
188neurofilament cytoskeleton organization (GO:0060052)2.52845413
189regulation of microtubule-based movement (GO:0060632)2.52025825
190adaptation of signaling pathway (GO:0023058)2.50302561
191dentate gyrus development (GO:0021542)2.49764910

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.75759584
2GBX2_23144817_ChIP-Seq_PC3_Human4.46175075
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.47699922
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.44038100
5TAF15_26573619_Chip-Seq_HEK293_Human3.30397220
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.26962286
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.21988174
8SUZ12_18692474_ChIP-Seq_MEFs_Mouse3.03870119
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.01717309
10* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.80423945
11REST_21632747_ChIP-Seq_MESCs_Mouse2.64669352
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.55247803
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.51927388
14* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.48910875
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.45708349
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.40384156
17CTBP1_25329375_ChIP-Seq_LNCAP_Human2.40326784
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.36443433
19REST_18959480_ChIP-ChIP_MESCs_Mouse2.36327555
20* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.36019752
21* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.34899110
22* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.34899110
23* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.33878513
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.32662340
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.21510128
26NR3C1_23031785_ChIP-Seq_PC12_Mouse2.18530074
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.17347780
28IKZF1_21737484_ChIP-ChIP_HCT116_Human1.98564437
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.94543297
30DROSHA_22980978_ChIP-Seq_HELA_Human1.93539786
31* SMAD4_21799915_ChIP-Seq_A2780_Human1.92233906
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.91848731
33* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.89829163
34* P300_19829295_ChIP-Seq_ESCs_Human1.87537167
35AR_21572438_ChIP-Seq_LNCaP_Human1.87252280
36POU3F2_20337985_ChIP-ChIP_501MEL_Human1.86638010
37ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.84179899
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.81753614
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.79497787
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.77730645
41SUZ12_27294783_Chip-Seq_ESCs_Mouse1.73585083
42RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.70036084
43EZH2_27294783_Chip-Seq_ESCs_Mouse1.69140687
44WT1_19549856_ChIP-ChIP_CCG9911_Human1.64228885
45ERG_21242973_ChIP-ChIP_JURKAT_Human1.62892290
46FUS_26573619_Chip-Seq_HEK293_Human1.62246308
47* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61719270
48NANOG_18555785_Chip-Seq_ESCs_Mouse1.60099997
49CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.58402513
50PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.58389238
51RARB_27405468_Chip-Seq_BRAIN_Mouse1.55081310
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.51624371
53CDX2_19796622_ChIP-Seq_MESCs_Mouse1.49594583
54* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.49219029
55SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47859541
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46335464
57TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.46326514
58SOX2_21211035_ChIP-Seq_LN229_Gbm1.41847911
59EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.41468715
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.40484476
61ZNF217_24962896_ChIP-Seq_MCF-7_Human1.38053932
62* RNF2_27304074_Chip-Seq_ESCs_Mouse1.37954560
63* AR_25329375_ChIP-Seq_VCAP_Human1.35852924
64UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.35082878
65* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.32435857
66FLI1_27457419_Chip-Seq_LIVER_Mouse1.28977545
67BCAT_22108803_ChIP-Seq_LS180_Human1.28948910
68DNAJC2_21179169_ChIP-ChIP_NT2_Human1.28080766
69P53_22387025_ChIP-Seq_ESCs_Mouse1.24483102
70FOXA1_25552417_ChIP-Seq_VCAP_Human1.24169198
71VDR_22108803_ChIP-Seq_LS180_Human1.23699933
72* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23113708
73EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.22891715
74HTT_18923047_ChIP-ChIP_STHdh_Human1.22480023
75CBX2_27304074_Chip-Seq_ESCs_Mouse1.21625409
76* JUN_21703547_ChIP-Seq_K562_Human1.20031900
77GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.18404207
78CMYC_18555785_Chip-Seq_ESCs_Mouse1.17531684
79STAT3_23295773_ChIP-Seq_U87_Human1.16934227
80HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.16832962
81EZH2_27294783_Chip-Seq_NPCs_Mouse1.16756264
82FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.16005628
83SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15760715
84ZNF274_21170338_ChIP-Seq_K562_Hela1.15357965
85PCGF2_27294783_Chip-Seq_ESCs_Mouse1.15329413
86* PRDM14_20953172_ChIP-Seq_ESCs_Human1.14059702
87STAT3_18555785_Chip-Seq_ESCs_Mouse1.14008909
88FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13695529
89GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.13295609
90E2F1_18555785_Chip-Seq_ESCs_Mouse1.12575281
91EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.12286569
92TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.12071049
93SUZ12_18555785_Chip-Seq_ESCs_Mouse1.11781691
94* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10893071
95NFE2_27457419_Chip-Seq_LIVER_Mouse1.08842162
96TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06673210
97RUNX2_22187159_ChIP-Seq_PCA_Human1.05242836
98SOX2_18555785_Chip-Seq_ESCs_Mouse1.04770308
99FLI1_21867929_ChIP-Seq_TH2_Mouse1.04362345
100EWS_26573619_Chip-Seq_HEK293_Human1.03556335
101TP53_22573176_ChIP-Seq_HFKS_Human1.01946269
102* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.01519959
103TRIM28_21343339_ChIP-Seq_HEK293_Human1.01344576
104CBP_20019798_ChIP-Seq_JUKART_Human1.00748976
105IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.00748976
106AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.00523662
107P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00121111
108P300_18555785_Chip-Seq_ESCs_Mouse1.00035665
109SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99422339
110NMYC_18555785_Chip-Seq_ESCs_Mouse0.98451672
111TAL1_26923725_Chip-Seq_HPCs_Mouse0.98301951
112ETV2_25802403_ChIP-Seq_MESCs_Mouse0.97620944
113CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.96778020
114TCF4_23295773_ChIP-Seq_U87_Human0.95425491
115MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.93175921
116ER_23166858_ChIP-Seq_MCF-7_Human0.92653130
117STAT6_21828071_ChIP-Seq_BEAS2B_Human0.92319426
118RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.91571962
119RING1B_27294783_Chip-Seq_ESCs_Mouse0.90894988
120TP53_18474530_ChIP-ChIP_U2OS_Human0.89956814
121FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.89304964
122CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88587202
123RNF2_27304074_Chip-Seq_NSC_Mouse0.88328424
124SMAD4_21741376_ChIP-Seq_HESCs_Human0.88177973
125MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.86616404
126TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86446153
127TCF4_22108803_ChIP-Seq_LS180_Human0.85784480
128* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.85688226
129EP300_21415370_ChIP-Seq_HL-1_Mouse0.84842270
130STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.83190472
131NR3C1_21868756_ChIP-Seq_MCF10A_Human0.83056244
132AR_19668381_ChIP-Seq_PC3_Human0.82823475
133ZNF263_19887448_ChIP-Seq_K562_Human0.82672010
134IGF1R_20145208_ChIP-Seq_DFB_Human0.81430993
135SMAD3_21741376_ChIP-Seq_HESCs_Human0.81034109

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy6.95870230
2MP0001529_abnormal_vocalization4.16959125
3MP0004858_abnormal_nervous_system3.88504338
4MP0003283_abnormal_digestive_organ3.78264505
5MP0003646_muscle_fatigue3.64792647
6MP0003011_delayed_dark_adaptation3.46671159
7MP0009745_abnormal_behavioral_response3.20127288
8MP0002638_abnormal_pupillary_reflex3.18620776
9MP0003635_abnormal_synaptic_transmissio2.94281051
10MP0004859_abnormal_synaptic_plasticity2.92620097
11MP0005645_abnormal_hypothalamus_physiol2.84309611
12MP0001501_abnormal_sleep_pattern2.81615284
13MP0010386_abnormal_urinary_bladder2.78867761
14MP0001440_abnormal_grooming_behavior2.78772324
15MP0009046_muscle_twitch2.73056814
16* MP0002064_seizures2.68319082
17MP0006276_abnormal_autonomic_nervous2.56902318
18MP0002734_abnormal_mechanical_nocicepti2.47352070
19MP0002572_abnormal_emotion/affect_behav2.44014308
20MP0002272_abnormal_nervous_system2.42461253
21MP0001905_abnormal_dopamine_level2.35052438
22MP0008872_abnormal_physiological_respon2.33338727
23MP0001944_abnormal_pancreas_morphology2.32419540
24MP0009780_abnormal_chondrocyte_physiolo2.28402304
25MP0001970_abnormal_pain_threshold2.26835498
26MP0002733_abnormal_thermal_nociception2.21887243
27MP0002837_dystrophic_cardiac_calcinosis2.20533126
28MP0001968_abnormal_touch/_nociception2.15782184
29MP0003122_maternal_imprinting2.06326817
30MP0000569_abnormal_digit_pigmentation2.06234768
31MP0004270_analgesia2.04976549
32MP0005167_abnormal_blood-brain_barrier2.04605216
33MP0002063_abnormal_learning/memory/cond2.03374530
34MP0002693_abnormal_pancreas_physiology2.02272090
35MP0002736_abnormal_nociception_after1.99119491
36MP0004233_abnormal_muscle_weight1.94191250
37MP0002102_abnormal_ear_morphology1.94126211
38MP0004043_abnormal_pH_regulation1.89792000
39MP0003195_calcinosis1.87801578
40MP0004924_abnormal_behavior1.80553167
41MP0005386_behavior/neurological_phenoty1.80553167
42MP0010234_abnormal_vibrissa_follicle1.79912390
43MP0002735_abnormal_chemical_nociception1.78441579
44MP0002938_white_spotting1.76752077
45MP0000538_abnormal_urinary_bladder1.66719053
46MP0000462_abnormal_digestive_system1.64940697
47MP0003787_abnormal_imprinting1.57352511
48MP0005448_abnormal_energy_balance1.53900170
49MP0001986_abnormal_taste_sensitivity1.51864073
50MP0006072_abnormal_retinal_apoptosis1.49860927
51MP0005075_abnormal_melanosome_morpholog1.49216832
52MP0000516_abnormal_urinary_system1.47385458
53MP0005367_renal/urinary_system_phenotyp1.47385458
54MP0008961_abnormal_basal_metabolism1.46917503
55MP0005253_abnormal_eye_physiology1.45117934
56MP0004084_abnormal_cardiac_muscle1.45034037
57MP0000013_abnormal_adipose_tissue1.44235153
58MP0002078_abnormal_glucose_homeostasis1.40332287
59MP0003045_fibrosis1.37727054
60MP0002184_abnormal_innervation1.36263738
61MP0002254_reproductive_system_inflammat1.30387071
62MP0002557_abnormal_social/conspecific_i1.27732799
63MP0002067_abnormal_sensory_capabilities1.25371347
64MP0004036_abnormal_muscle_relaxation1.23381353
65MP0005220_abnormal_exocrine_pancreas1.23070033
66MP0004484_altered_response_of1.22926875
67MP0002751_abnormal_autonomic_nervous1.22607535
68MP0000639_abnormal_adrenal_gland1.22313845
69MP0003633_abnormal_nervous_system1.21622361
70MP0008775_abnormal_heart_ventricle1.18621366
71MP0008569_lethality_at_weaning1.18486561
72MP0008874_decreased_physiological_sensi1.18296365
73MP0005551_abnormal_eye_electrophysiolog1.18202024
74MP0004811_abnormal_neuron_physiology1.17779789
75MP0004883_abnormal_blood_vessel1.17444457
76MP0001188_hyperpigmentation1.16951431
77MP0002163_abnormal_gland_morphology1.16387270
78MP0000631_abnormal_neuroendocrine_gland1.14290468
79MP0005197_abnormal_uvea_morphology1.13958630
80MP0005423_abnormal_somatic_nervous1.11947071
81MP0006138_congestive_heart_failure1.09672767
82MP0002127_abnormal_cardiovascular_syste1.09555759
83MP0003880_abnormal_central_pattern1.09170649
84MP0001984_abnormal_olfaction1.09112608
85MP0005646_abnormal_pituitary_gland1.08504114
86MP0000613_abnormal_salivary_gland1.08314077
87MP0003631_nervous_system_phenotype1.06704652
88MP0001486_abnormal_startle_reflex1.06683027
89MP0002909_abnormal_adrenal_gland1.06565453
90MP0010329_abnormal_lipoprotein_level1.06517167
91MP0005535_abnormal_body_temperature1.04769148
92MP0002234_abnormal_pharynx_morphology1.04144100
93MP0000955_abnormal_spinal_cord1.03994546
94MP0004885_abnormal_endolymph1.03888427
95MP0002332_abnormal_exercise_endurance1.02233912
96MP0004142_abnormal_muscle_tone1.00311989
97MP0009379_abnormal_foot_pigmentation0.99371257
98MP0002229_neurodegeneration0.96387843
99MP0000751_myopathy0.96073547
100MP0003953_abnormal_hormone_level0.95922971
101MP0003121_genomic_imprinting0.94761416
102MP0002066_abnormal_motor_capabilities/c0.89623530
103MP0000003_abnormal_adipose_tissue0.88848185
104MP0002069_abnormal_eating/drinking_beha0.88415023
105MP0001664_abnormal_digestion0.88407853
106MP0008789_abnormal_olfactory_epithelium0.87484527
107MP0009840_abnormal_foam_cell0.86769791
108MP0004145_abnormal_muscle_electrophysio0.86099893
109MP0002295_abnormal_pulmonary_circulatio0.84846220
110MP0003329_amyloid_beta_deposits0.84327633
111MP0005636_abnormal_mineral_homeostasis0.83719927
112MP0001756_abnormal_urination0.81835363
113MP0001502_abnormal_circadian_rhythm0.81754244
114MP0005379_endocrine/exocrine_gland_phen0.81466309
115MP0002009_preneoplasia0.80967238
116MP0003123_paternal_imprinting0.80900059
117MP0000372_irregular_coat_pigmentation0.79731862
118MP0002882_abnormal_neuron_morphology0.76581025
119MP0001485_abnormal_pinna_reflex0.76114850
120MP0001177_atelectasis0.75110514
121MP0004133_heterotaxia0.75079154
122MP0004085_abnormal_heartbeat0.73670833
123MP0005085_abnormal_gallbladder_physiolo0.73434930
124MP0002090_abnormal_vision0.72973083
125MP0002876_abnormal_thyroid_physiology0.71003238
126MP0008877_abnormal_DNA_methylation0.68636604
127MP0000778_abnormal_nervous_system0.68391835
128MP0001270_distended_abdomen0.66347214
129MP0005394_taste/olfaction_phenotype0.65088579
130MP0005499_abnormal_olfactory_system0.65088579
131MP0003632_abnormal_nervous_system0.64523034
132MP0004215_abnormal_myocardial_fiber0.63792201
133MP0005408_hypopigmentation0.63240940
134MP0000467_abnormal_esophagus_morphology0.59721105
135MP0002277_abnormal_respiratory_mucosa0.57470838
136MP0002152_abnormal_brain_morphology0.54960238
137MP0003718_maternal_effect0.54349997
138MP0001943_abnormal_respiration0.50973710
139MP0005171_absent_coat_pigmentation0.47589217
140MP0001764_abnormal_homeostasis0.46440760

Predicted human phenotypes

RankGene SetZ-score
1Hypothermia (HP:0002045)9.73613482
2Focal motor seizures (HP:0011153)6.57952652
3Myokymia (HP:0002411)5.76024855
4Orthostatic hypotension (HP:0001278)5.51876083
5Hypoglycemic seizures (HP:0002173)5.43372499
6Hyperinsulinemic hypoglycemia (HP:0000825)4.89745045
7Atonic seizures (HP:0010819)4.84172442
8Abnormal autonomic nervous system physiology (HP:0012332)4.78505617
9Abnormal hair whorl (HP:0010721)4.69392214
10Hyperglycemia (HP:0003074)4.63208260
11Ketoacidosis (HP:0001993)4.50554745
12Neonatal hypoglycemia (HP:0001998)4.35529887
13Focal seizures (HP:0007359)4.34256682
14Oligomenorrhea (HP:0000876)4.26485657
15Hypoglycemic coma (HP:0001325)4.20863411
16Polyphagia (HP:0002591)4.19771809
17Abnormality of endocrine pancreas physiology (HP:0012093)4.10938610
18Abnormality of the pancreatic islet cells (HP:0006476)4.10938610
19Limb dystonia (HP:0002451)3.90885382
20Febrile seizures (HP:0002373)3.85514475
21Generalized tonic-clonic seizures (HP:0002069)3.65835048
22Acute necrotizing encephalopathy (HP:0006965)3.61431387
23Spastic diplegia (HP:0001264)3.61034351
24Absence seizures (HP:0002121)3.54472062
25Pheochromocytoma (HP:0002666)3.53840793
26Neuroendocrine neoplasm (HP:0100634)3.52583819
27Insulin-resistant diabetes mellitus (HP:0000831)3.47659029
28Abnormality of the labia minora (HP:0012880)3.47357524
29Visual hallucinations (HP:0002367)3.44453676
30Failure to thrive in infancy (HP:0001531)3.37783437
31Abnormal mitochondria in muscle tissue (HP:0008316)3.37110406
32Amblyopia (HP:0000646)3.35864483
33Poor suck (HP:0002033)3.32149527
34Hemiparesis (HP:0001269)3.30529065
35Exotropia (HP:0000577)3.26199013
36Progressive cerebellar ataxia (HP:0002073)3.22553062
37Symptomatic seizures (HP:0011145)3.20798932
38Hyperventilation (HP:0002883)3.20186018
39Epileptic encephalopathy (HP:0200134)3.18465678
40Progressive macrocephaly (HP:0004481)3.18126355
41Hypoventilation (HP:0002791)3.13087406
42Dialeptic seizures (HP:0011146)3.07604165
43Large for gestational age (HP:0001520)3.07554883
44Autoamputation (HP:0001218)3.05842119
45Mitochondrial inheritance (HP:0001427)3.02676046
46Intestinal atresia (HP:0011100)2.97124096
47Abnormal eating behavior (HP:0100738)2.96643360
48Impaired pain sensation (HP:0007328)2.95386681
49Abnormality of pain sensation (HP:0010832)2.95386681
50Ketosis (HP:0001946)2.87895752
51Acute encephalopathy (HP:0006846)2.79377742
52Patchy hypopigmentation of hair (HP:0011365)2.77097368
53Enlarged penis (HP:0000040)2.75244757
54Narrow nasal bridge (HP:0000446)2.73687712
55Late onset (HP:0003584)2.70065504
56Epileptiform EEG discharges (HP:0011182)2.63264899
57White forelock (HP:0002211)2.61726999
58Abnormal pancreas size (HP:0012094)2.59008433
59Hepatoblastoma (HP:0002884)2.56757478
60Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.56158153
61Myotonia (HP:0002486)2.48875586
62Increased CSF lactate (HP:0002490)2.45927877
63EEG with generalized epileptiform discharges (HP:0011198)2.44994645
64Poor eye contact (HP:0000817)2.44441066
65Anxiety (HP:0000739)2.43740991
66Hypsarrhythmia (HP:0002521)2.41663297
67Spastic tetraplegia (HP:0002510)2.40686791
68Hypomagnesemia (HP:0002917)2.39962749
69Increased circulating renin level (HP:0000848)2.38628933
70Abnormal sex determination (HP:0012244)2.33674861
71Sex reversal (HP:0012245)2.33674861
72Proximal tubulopathy (HP:0000114)2.33389264
73Heterochromia iridis (HP:0001100)2.33227601
74Hyperthyroidism (HP:0000836)2.30142153
75Agitation (HP:0000713)2.29467841
76Hypotension (HP:0002615)2.27651351
77Calf muscle hypertrophy (HP:0008981)2.26933606
78Cerebral edema (HP:0002181)2.26443752
79Resting tremor (HP:0002322)2.26436994
80Neoplasm of the adrenal cortex (HP:0100641)2.24778875
81Type II lissencephaly (HP:0007260)2.24068966
82Hepatocellular necrosis (HP:0001404)2.23545836
83Disproportionate short-trunk short stature (HP:0003521)2.23114442
84Abnormal pupillary function (HP:0007686)2.23030467
85Restlessness (HP:0000711)2.18617284
86Esotropia (HP:0000565)2.17252502
87Abnormal gallbladder physiology (HP:0012438)2.16619095
88Cholecystitis (HP:0001082)2.16619095
89Abnormality of the metopic suture (HP:0005556)2.16152158
90Specific learning disability (HP:0001328)2.13210976
91Nephrogenic diabetes insipidus (HP:0009806)2.13179048
92Neoplasm of the peripheral nervous system (HP:0100007)2.12733022
93Psychosis (HP:0000709)2.11667559
94Aplasia/Hypoplasia of the brainstem (HP:0007362)2.11497512
95Hypoplasia of the brainstem (HP:0002365)2.11497512
96Polydipsia (HP:0001959)2.10389720
97Abnormal drinking behavior (HP:0030082)2.10389720
98Hypokinesia (HP:0002375)2.07905655
99Nasal speech (HP:0001611)2.07873856
100Dysdiadochokinesis (HP:0002075)2.07431338
101Abnormality of aromatic amino acid family metabolism (HP:0004338)2.07095804
102Generalized myoclonic seizures (HP:0002123)2.06207981
103Tongue fasciculations (HP:0001308)2.06150775
104Termporal pattern (HP:0011008)2.04888826
105Insidious onset (HP:0003587)2.04888826
106Testicular neoplasm (HP:0010788)2.04655989
107Truncal ataxia (HP:0002078)2.04647422
108Loss of speech (HP:0002371)2.04360430
109Prominent metopic ridge (HP:0005487)2.04023203
110Abnormality of vitamin B metabolism (HP:0004340)2.04002202
111Impaired vibration sensation in the lower limbs (HP:0002166)2.03158536
112Malnutrition (HP:0004395)2.02464369
113Gait imbalance (HP:0002141)2.02154717
114Abnormal social behavior (HP:0012433)2.01364279
115Impaired social interactions (HP:0000735)2.01364279
116Optic disc pallor (HP:0000543)2.00596199
117Abnormality of the corticospinal tract (HP:0002492)1.99897201
118Increased serum pyruvate (HP:0003542)1.98839993
119Abnormality of glycolysis (HP:0004366)1.98839993
120Depression (HP:0000716)1.98462890
121Leukodystrophy (HP:0002415)1.97509465
122Muscle hypertrophy of the lower extremities (HP:0008968)1.91577235
123Abnormality of the vocal cords (HP:0008777)1.90935185
124Pancreatic islet-cell hyperplasia (HP:0004510)1.90242485
125Fetal akinesia sequence (HP:0001989)1.88071684
126Muscular hypotonia of the trunk (HP:0008936)1.88009387
127Increased CSF protein (HP:0002922)1.87548506
128Generalized hypotonia (HP:0001290)1.87176095
129Sensory axonal neuropathy (HP:0003390)1.84424608
130Postural tremor (HP:0002174)1.84224103
131Impaired vibratory sensation (HP:0002495)1.83630007
132Abnormality of polysaccharide metabolism (HP:0011012)1.82333830
133Abnormality of glycosaminoglycan metabolism (HP:0004371)1.82333830
134Abnormality of mucopolysaccharide metabolism (HP:0011020)1.82333830
135Absent speech (HP:0001344)1.82197119
136Emotional lability (HP:0000712)1.82081595
137Sleep apnea (HP:0010535)1.81414172
138Degeneration of the lateral corticospinal tracts (HP:0002314)1.81373262
139Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.81373262
140Neoplasm of head and neck (HP:0012288)1.81093671
141Esophageal neoplasm (HP:0100751)1.81093671
142Progressive inability to walk (HP:0002505)1.79936890
143Cerebellar dysplasia (HP:0007033)1.79195160
144Diminished movement (HP:0002374)1.79115316
145Dysmetria (HP:0001310)1.78437869
146X-linked dominant inheritance (HP:0001423)1.77024163
147Congenital primary aphakia (HP:0007707)1.76973447
148Barrel-shaped chest (HP:0001552)1.76690956
149Macroorchidism (HP:0000053)1.76517353
150Abnormality of magnesium homeostasis (HP:0004921)1.75751503
151Gaze-evoked nystagmus (HP:0000640)1.74608380
152Urinary glycosaminoglycan excretion (HP:0003541)1.73111059
153Mucopolysacchariduria (HP:0008155)1.73111059
154Hyperphosphatemia (HP:0002905)1.73085936
155Type I diabetes mellitus (HP:0100651)1.71981987
156Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.71843208
157Respiratory failure (HP:0002878)1.70954600
158Syncope (HP:0001279)1.70844043
159Progressive microcephaly (HP:0000253)1.70640773
160Cortical visual impairment (HP:0100704)1.70451594
161Status epilepticus (HP:0002133)1.70111382
162Ankle clonus (HP:0011448)1.69511256
163Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.69350665
164Menstrual irregularities (HP:0000858)1.69011396
165Tachypnea (HP:0002789)1.68883598
166True hermaphroditism (HP:0010459)1.68861795
167Medial flaring of the eyebrow (HP:0010747)1.67790181

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.70480151
2GRK75.79090218
3MAP3K124.73790963
4MAP3K44.57355646
5MAP2K74.20758871
6TRIM283.61835594
7NTRK13.56108516
8MAP2K42.74590828
9ARAF2.64812777
10FGFR22.54075106
11CASK2.38067687
12PASK2.37410342
13GRK52.35995699
14MAP4K22.23533195
15MATK2.17356428
16NTRK32.10309506
17PAK32.07443267
18NTRK21.94607470
19PNCK1.92448072
20MAP3K91.79418888
21PRKD31.78845135
22CAMK1D1.78614838
23ACVR1B1.78258423
24NME11.72658329
25DAPK11.72063095
26TSSK61.70252962
27MAP2K61.68105894
28MYLK1.67159855
29NLK1.66681971
30CAMK1G1.66553507
31MINK11.55580637
32AKT31.54107195
33MUSK1.52257096
34PRKCE1.47290611
35ERBB31.46161738
36MAP2K11.43921259
37ADRBK11.40445523
38DAPK21.38359563
39KSR21.24924405
40PLK21.24276774
41CAMK11.23904787
42CAMK41.23012410
43MKNK21.21237370
44RPS6KL11.20003776
45RPS6KC11.20003776
46UHMK11.18746448
47PINK11.18700331
48MARK11.14502373
49CSNK1G21.11495021
50PDK31.09307598
51PDK41.09307598
52PRKCG1.06776768
53CSNK1G31.04732762
54HIPK21.03691864
55STK391.01734610
56STK30.99943858
57LIMK10.99694147
58SGK30.99517192
59PRKD20.98957668
60TAOK10.98707304
61CAMK2A0.97973018
62RPS6KA60.97675693
63EIF2AK30.97517935
64CDK50.93691738
65BRAF0.91801550
66SGK2230.91253235
67SGK4940.91253235
68CAMK2B0.89984037
69STK38L0.86253492
70CSNK1A1L0.85433479
71MAP3K20.82969565
72MST40.81592544
73DYRK30.80638075
74FGFR30.79106425
75MAPK130.78609996
76GRK10.76485981
77YES10.76200883
78DAPK30.75612200
79MAPKAPK50.73688258
80RPS6KA20.71919921
81SIK20.70765992
82FES0.70751110
83STK240.70316956
84INSRR0.70182074
85CDK30.68399875
86ERBB40.68051724
87DMPK0.67255825
88SIK30.63909680
89EPHA30.63587453
90CDK190.63137922
91SGK10.62813118
92STK110.61577755
93BMPR1B0.61466591
94CAMK2G0.61331391
95CDK140.60846852
96CAMKK20.60301639
97BRD40.60060652
98DYRK1A0.59747807
99CDK180.59584879
100CAMK2D0.59294122
101CSNK1A10.58167497
102CDK150.57951897
103GRK60.57567707
104CSNK1G10.56130384
105NEK10.54223960
106PDK20.52833257
107PRKCI0.52728219
108PRKAA10.52270706
109SGK20.51461253
110NUAK10.51190140
111OXSR10.48900336
112RPS6KA50.48879977
113MAP3K10.48604057
114PHKG10.48424346
115PHKG20.48424346
116GSK3A0.47039510
117CDK11A0.46799623
118CSNK1D0.46640772
119CDC42BPA0.46366126
120PRKCZ0.44487337
121PRKACA0.44038752
122MAP3K130.43135403
123ALK0.42801770
124RAF10.42163690
125PRKAA20.41340760
126ROCK10.41108928
127MAP3K60.40574301
128WNK10.40505563
129EPHA40.39204602
130FER0.39203318
131PIM20.39062392
132BUB10.38490379
133PTK2B0.36970218
134PRKDC0.36639192
135CCNB10.35823598
136TESK10.33888623
137ROCK20.33857462
138LMTK20.32687348
139PAK60.32374174
140PRKCH0.31906283
141PRKACG0.31450646
142ADRBK20.30796516
143CAMKK10.30611857
144CSNK1E0.30000864
145WNK40.29023572
146MOS0.26992581
147LATS20.26508099
148WNK30.26423289
149PRKCB0.24781617
150SYK0.21243057
151PRKCA0.20551367

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049506.87561114
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004304.79063251
3Collecting duct acid secretion_Homo sapiens_hsa049663.69706127
4Synaptic vesicle cycle_Homo sapiens_hsa047213.61053367
5Oxidative phosphorylation_Homo sapiens_hsa001902.99376382
6Protein export_Homo sapiens_hsa030602.88665460
7Butanoate metabolism_Homo sapiens_hsa006502.67218173
8Vibrio cholerae infection_Homo sapiens_hsa051102.51604769
9Type I diabetes mellitus_Homo sapiens_hsa049402.43660500
10Nicotine addiction_Homo sapiens_hsa050332.41707173
11GABAergic synapse_Homo sapiens_hsa047272.41665977
12Parkinsons disease_Homo sapiens_hsa050122.16568890
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.02517399
14Long-term depression_Homo sapiens_hsa047301.97444094
15Tyrosine metabolism_Homo sapiens_hsa003501.97190706
16Alzheimers disease_Homo sapiens_hsa050101.91346742
17Circadian entrainment_Homo sapiens_hsa047131.88361124
18Phenylalanine metabolism_Homo sapiens_hsa003601.85909212
19Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.84278306
20Regulation of autophagy_Homo sapiens_hsa041401.82008518
21Taste transduction_Homo sapiens_hsa047421.81394865
22Dopaminergic synapse_Homo sapiens_hsa047281.81001022
23Arginine biosynthesis_Homo sapiens_hsa002201.79723143
24Selenocompound metabolism_Homo sapiens_hsa004501.77925982
25Amphetamine addiction_Homo sapiens_hsa050311.76416639
26Cocaine addiction_Homo sapiens_hsa050301.74262579
27Serotonergic synapse_Homo sapiens_hsa047261.70212590
28Olfactory transduction_Homo sapiens_hsa047401.69301582
29Cholinergic synapse_Homo sapiens_hsa047251.68646970
30Fatty acid biosynthesis_Homo sapiens_hsa000611.67437696
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.65883706
32Salivary secretion_Homo sapiens_hsa049701.65810477
33Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.64788906
34Morphine addiction_Homo sapiens_hsa050321.61882643
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.58459108
36Circadian rhythm_Homo sapiens_hsa047101.50743711
37Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.46029479
38Renin secretion_Homo sapiens_hsa049241.44884954
39Long-term potentiation_Homo sapiens_hsa047201.43079963
40Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.39917838
41Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.39531995
42Sphingolipid metabolism_Homo sapiens_hsa006001.36041965
43Phagosome_Homo sapiens_hsa041451.33847130
44Glutamatergic synapse_Homo sapiens_hsa047241.33374583
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32721139
46Peroxisome_Homo sapiens_hsa041461.29593601
47Huntingtons disease_Homo sapiens_hsa050161.28079431
48Rheumatoid arthritis_Homo sapiens_hsa053231.26251862
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.22593429
50Vitamin B6 metabolism_Homo sapiens_hsa007501.20494294
51beta-Alanine metabolism_Homo sapiens_hsa004101.19602132
52Ether lipid metabolism_Homo sapiens_hsa005651.19418116
53Insulin secretion_Homo sapiens_hsa049111.19238358
54Gap junction_Homo sapiens_hsa045401.14182278
55Proteasome_Homo sapiens_hsa030501.12988366
56Calcium signaling pathway_Homo sapiens_hsa040201.11428158
57Gastric acid secretion_Homo sapiens_hsa049711.05804939
58Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.04553829
59Pyruvate metabolism_Homo sapiens_hsa006200.99305156
60Fatty acid metabolism_Homo sapiens_hsa012120.99271957
61Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.98129379
62Histidine metabolism_Homo sapiens_hsa003400.94050092
63Fatty acid elongation_Homo sapiens_hsa000620.92562447
64Cardiac muscle contraction_Homo sapiens_hsa042600.92277133
65Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.90179015
66Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.88404938
67Aldosterone synthesis and secretion_Homo sapiens_hsa049250.87172155
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.86216329
69Glycosaminoglycan degradation_Homo sapiens_hsa005310.83888414
70Mineral absorption_Homo sapiens_hsa049780.83107586
71ABC transporters_Homo sapiens_hsa020100.83083148
72Renin-angiotensin system_Homo sapiens_hsa046140.82992932
73Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.79211628
74Arginine and proline metabolism_Homo sapiens_hsa003300.78606319
75Oxytocin signaling pathway_Homo sapiens_hsa049210.78355364
76GnRH signaling pathway_Homo sapiens_hsa049120.76786154
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67445967
78Estrogen signaling pathway_Homo sapiens_hsa049150.66615892
79alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.61933001
80African trypanosomiasis_Homo sapiens_hsa051430.60960947
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.60667764
82N-Glycan biosynthesis_Homo sapiens_hsa005100.60547813
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.59644827
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59533588
85Fatty acid degradation_Homo sapiens_hsa000710.58665047
86Thyroid hormone synthesis_Homo sapiens_hsa049180.55692980
87Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55107734
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.54384365
89Lysosome_Homo sapiens_hsa041420.53796366
90Linoleic acid metabolism_Homo sapiens_hsa005910.53440880
91Steroid biosynthesis_Homo sapiens_hsa001000.52774459
92Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50369930
93Primary bile acid biosynthesis_Homo sapiens_hsa001200.50361516
94Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50319659
95Type II diabetes mellitus_Homo sapiens_hsa049300.49191369
96Pancreatic secretion_Homo sapiens_hsa049720.48878666
97Bile secretion_Homo sapiens_hsa049760.47998267
982-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.45349554
99Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.45307311
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43387058
101Glutathione metabolism_Homo sapiens_hsa004800.43136130
102Oocyte meiosis_Homo sapiens_hsa041140.40090126
103AMPK signaling pathway_Homo sapiens_hsa041520.39952499
104Melanogenesis_Homo sapiens_hsa049160.38992939
105cGMP-PKG signaling pathway_Homo sapiens_hsa040220.38664533
106Glucagon signaling pathway_Homo sapiens_hsa049220.38111400
107* cAMP signaling pathway_Homo sapiens_hsa040240.38077541
108TGF-beta signaling pathway_Homo sapiens_hsa043500.35986879
109Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.34721787
110Tryptophan metabolism_Homo sapiens_hsa003800.34495726
111* Alcoholism_Homo sapiens_hsa050340.34067383
112Sulfur metabolism_Homo sapiens_hsa009200.33753870
113Hedgehog signaling pathway_Homo sapiens_hsa043400.33139285
114Retinol metabolism_Homo sapiens_hsa008300.32960560
115Folate biosynthesis_Homo sapiens_hsa007900.32285468
116Tight junction_Homo sapiens_hsa045300.31932723
117Prion diseases_Homo sapiens_hsa050200.30272662
118Axon guidance_Homo sapiens_hsa043600.26496592
119Phosphatidylinositol signaling system_Homo sapiens_hsa040700.24116218
120Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.24048283
121Carbon metabolism_Homo sapiens_hsa012000.23124606
122Ovarian steroidogenesis_Homo sapiens_hsa049130.20525595
123ErbB signaling pathway_Homo sapiens_hsa040120.19754551
124Dilated cardiomyopathy_Homo sapiens_hsa054140.19453272
125Glycerolipid metabolism_Homo sapiens_hsa005610.19307418
126Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.18078366
127Metabolic pathways_Homo sapiens_hsa011000.17929963
128Dorso-ventral axis formation_Homo sapiens_hsa043200.13212950
129Sphingolipid signaling pathway_Homo sapiens_hsa040710.12686760
130Propanoate metabolism_Homo sapiens_hsa006400.12660994
131Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.10253447
132Phototransduction_Homo sapiens_hsa047440.09773245
133Phospholipase D signaling pathway_Homo sapiens_hsa040720.09389675
134Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.09361319
135Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.09336538
136Insulin signaling pathway_Homo sapiens_hsa049100.08310584
137Glioma_Homo sapiens_hsa052140.05831807

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