NPTX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: NPTX1 is a member of the neuronal pentraxin gene family. Neuronal pentraxin 1 is similar to the rat NP1 gene which encodes a binding protein for the snake venom toxin taipoxin. Human NPTX1 mRNA is exclusively localized to the nervous system. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.35332483
2locomotory exploration behavior (GO:0035641)6.28813359
3synaptic vesicle maturation (GO:0016188)6.15036763
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.90370559
5synaptic vesicle exocytosis (GO:0016079)5.59974165
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.57644293
7glutamate secretion (GO:0014047)5.50221622
8ionotropic glutamate receptor signaling pathway (GO:0035235)5.43695100
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.34690516
10vocalization behavior (GO:0071625)5.34170074
11neuronal action potential propagation (GO:0019227)5.31732102
12synaptic vesicle docking involved in exocytosis (GO:0016081)5.10707404
13regulation of glutamate receptor signaling pathway (GO:1900449)4.96882047
14glutamate receptor signaling pathway (GO:0007215)4.92895431
15regulation of synaptic vesicle exocytosis (GO:2000300)4.86745335
16synaptic transmission, glutamatergic (GO:0035249)4.84429577
17exploration behavior (GO:0035640)4.81876956
18regulation of neuronal synaptic plasticity (GO:0048168)4.77040961
19cellular potassium ion homeostasis (GO:0030007)4.73547056
20potassium ion homeostasis (GO:0055075)4.66818412
21amino acid import (GO:0043090)4.64741146
22regulation of long-term neuronal synaptic plasticity (GO:0048169)4.57404209
23protein localization to synapse (GO:0035418)4.51260935
24sodium ion export (GO:0071436)4.51020703
25neurotransmitter secretion (GO:0007269)4.43737287
26regulation of synaptic vesicle transport (GO:1902803)4.42308905
27positive regulation of synapse maturation (GO:0090129)4.42206376
28long-term memory (GO:0007616)4.38102055
29negative regulation of dendrite morphogenesis (GO:0050774)4.34396283
30cerebellar granule cell differentiation (GO:0021707)4.31449287
31neuron-neuron synaptic transmission (GO:0007270)4.24617037
32cerebellar Purkinje cell differentiation (GO:0021702)4.19182244
33regulation of excitatory postsynaptic membrane potential (GO:0060079)4.19135894
34axon ensheathment in central nervous system (GO:0032291)4.13606676
35central nervous system myelination (GO:0022010)4.13606676
36gamma-aminobutyric acid transport (GO:0015812)4.12945343
37G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.11157235
38neuromuscular process controlling posture (GO:0050884)4.06482823
39regulation of synapse structural plasticity (GO:0051823)4.05289311
40neuronal ion channel clustering (GO:0045161)4.02484865
41membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.99840113
42cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.96733435
43regulation of postsynaptic membrane potential (GO:0060078)3.94262255
44regulation of synaptic plasticity (GO:0048167)3.92537375
45regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.91723073
46synaptic vesicle endocytosis (GO:0048488)3.90826786
47dendritic spine morphogenesis (GO:0060997)3.90167442
48postsynaptic membrane organization (GO:0001941)3.89192165
49neurotransmitter-gated ion channel clustering (GO:0072578)3.88163007
50positive regulation of membrane potential (GO:0045838)3.87800716
51neuromuscular process controlling balance (GO:0050885)3.86897339
52gamma-aminobutyric acid signaling pathway (GO:0007214)3.84585263
53layer formation in cerebral cortex (GO:0021819)3.82283166
54proline transport (GO:0015824)3.77384686
55cell communication by electrical coupling (GO:0010644)3.75405850
56response to pheromone (GO:0019236)3.72124855
57cytoskeletal anchoring at plasma membrane (GO:0007016)3.70580269
58neuron cell-cell adhesion (GO:0007158)3.68401824
59regulation of voltage-gated calcium channel activity (GO:1901385)3.65603023
60positive regulation of neurotransmitter secretion (GO:0001956)3.58882471
61regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.58712721
62long-term synaptic potentiation (GO:0060291)3.58422372
63regulation of dendritic spine morphogenesis (GO:0061001)3.58156880
64innervation (GO:0060384)3.55353350
65cellular sodium ion homeostasis (GO:0006883)3.55128830
66cerebellar Purkinje cell layer development (GO:0021680)3.53812971
67neurotransmitter transport (GO:0006836)3.53373750
68neurotransmitter uptake (GO:0001504)3.50783955
69positive regulation of neurotransmitter transport (GO:0051590)3.49470836
70positive regulation of dendritic spine morphogenesis (GO:0061003)3.46520390
71transmission of nerve impulse (GO:0019226)3.46062363
72regulation of neurotransmitter secretion (GO:0046928)3.44887820
73positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.44230362
74establishment of nucleus localization (GO:0040023)3.43229650
75membrane depolarization (GO:0051899)3.39310173
76positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.38161592
77activation of protein kinase A activity (GO:0034199)3.36179970
78membrane depolarization during action potential (GO:0086010)3.35843988
79chemosensory behavior (GO:0007635)3.35457490
80dendrite morphogenesis (GO:0048813)3.35381245
81L-amino acid import (GO:0043092)3.34115953
82dendritic spine organization (GO:0097061)3.31462752
83regulation of synaptic transmission, glutamatergic (GO:0051966)3.30670641
84negative regulation of synaptic transmission, GABAergic (GO:0032229)3.30424662
85cell differentiation in hindbrain (GO:0021533)3.29446366
86regulation of synapse maturation (GO:0090128)3.29163351
87acidic amino acid transport (GO:0015800)3.27698230
88behavioral fear response (GO:0001662)3.27455011
89behavioral defense response (GO:0002209)3.27455011
90long term synaptic depression (GO:0060292)3.27445623
91regulation of neurotransmitter levels (GO:0001505)3.27251715
92regulation of vesicle fusion (GO:0031338)3.25110814
93neuromuscular process (GO:0050905)3.25050806
94positive regulation of dendritic spine development (GO:0060999)3.20488330
95negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.19723641
96regulation of ARF protein signal transduction (GO:0032012)3.19094344
97regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.18718526
98neuron recognition (GO:0008038)3.18127873
99potassium ion import (GO:0010107)3.17007049
100regulation of synaptic transmission (GO:0050804)3.16031981
101vesicle docking involved in exocytosis (GO:0006904)3.16007636
102presynaptic membrane organization (GO:0097090)3.15626355
103axonal fasciculation (GO:0007413)3.14064332
104regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.13654297
105cell communication involved in cardiac conduction (GO:0086065)3.12773842
106fear response (GO:0042596)3.11304661
107auditory behavior (GO:0031223)3.10524275
108synaptic vesicle transport (GO:0048489)3.10092855
109establishment of synaptic vesicle localization (GO:0097480)3.10092855
110regulation of neurotransmitter transport (GO:0051588)3.10052506
111glycine transport (GO:0015816)3.09776751
112positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.06553629
113dicarboxylic acid transport (GO:0006835)3.03994503
114learning (GO:0007612)3.03859161
115* synaptic transmission (GO:0007268)3.02604071
116cell migration in hindbrain (GO:0021535)3.02157161
117signal complex assembly (GO:0007172)3.01233464
118positive regulation of dendrite development (GO:1900006)2.99034043
119membrane hyperpolarization (GO:0060081)2.97861280
120G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.96068616
121mating behavior (GO:0007617)2.94880041
122regulation of dendritic spine development (GO:0060998)2.94194840
123positive regulation of synaptic transmission (GO:0050806)2.89780240
124regulation of calcium ion-dependent exocytosis (GO:0017158)2.88592522
125neuromuscular synaptic transmission (GO:0007274)2.86830645

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.43389414
2* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.20987263
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.12457998
4* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.07947804
5GBX2_23144817_ChIP-Seq_PC3_Human2.94680978
6* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.91725418
7* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.91725418
8* REST_21632747_ChIP-Seq_MESCs_Mouse2.78287369
9DROSHA_22980978_ChIP-Seq_HELA_Human2.75058471
10* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.74993848
11RARB_27405468_Chip-Seq_BRAIN_Mouse2.70010485
12* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.63701199
13* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.62621094
14* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.59009720
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.54367691
16IKZF1_21737484_ChIP-ChIP_HCT116_Human2.53819621
17* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.47927840
18* EZH2_27304074_Chip-Seq_ESCs_Mouse2.36470430
19* EZH2_27294783_Chip-Seq_ESCs_Mouse2.32346821
20* REST_18959480_ChIP-ChIP_MESCs_Mouse2.32200628
21* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.32070732
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.31861255
23* EED_16625203_ChIP-ChIP_MESCs_Mouse2.29964610
24* RNF2_27304074_Chip-Seq_ESCs_Mouse2.28206410
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.27578093
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.93383093
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.90465801
28ERG_21242973_ChIP-ChIP_JURKAT_Human1.90106696
29AR_21572438_ChIP-Seq_LNCaP_Human1.70390226
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.64594660
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.59005927
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51526056
33PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.47939904
34SMAD4_21799915_ChIP-Seq_A2780_Human1.46747009
35ZNF274_21170338_ChIP-Seq_K562_Hela1.46439689
36* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.44422273
37ESR2_21235772_ChIP-Seq_MCF-7_Human1.43698188
38RING1B_27294783_Chip-Seq_ESCs_Mouse1.43005978
39DNAJC2_21179169_ChIP-ChIP_NT2_Human1.42997042
40SRY_22984422_ChIP-ChIP_TESTIS_Rat1.41678012
41KDM2B_26808549_Chip-Seq_K562_Human1.40188002
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.36661708
43* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35887544
44SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.34756304
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33178725
46THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.32405856
47* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.32066921
48GATA1_26923725_Chip-Seq_HPCs_Mouse1.29206059
49AR_19668381_ChIP-Seq_PC3_Human1.26765649
50* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.26683135
51* RING1B_27294783_Chip-Seq_NPCs_Mouse1.25472676
52WT1_25993318_ChIP-Seq_PODOCYTE_Human1.24653731
53* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.24558126
54TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.24551954
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.19364100
56* SOX2_21211035_ChIP-Seq_LN229_Gbm1.18720912
57RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.18648891
58* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.18315343
59* SMC4_20622854_ChIP-Seq_HELA_Human1.17470822
60NR3C1_23031785_ChIP-Seq_PC12_Mouse1.15391679
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12762777
62* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12061657
63* AR_25329375_ChIP-Seq_VCAP_Human1.10705396
64CTNNB1_20460455_ChIP-Seq_HCT116_Human1.10335940
65ZFP281_27345836_Chip-Seq_ESCs_Mouse1.10258950
66STAT3_23295773_ChIP-Seq_U87_Human1.09000588
67TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04041552
68* KDM2B_26808549_Chip-Seq_DND41_Human1.04007448
69SMAD3_21741376_ChIP-Seq_EPCs_Human1.02945171
70CREB1_26743006_Chip-Seq_LNCaP_Human1.02874083
71ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02104749
72SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.01644317
73ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.00708064
74TET1_21490601_ChIP-Seq_MESCs_Mouse1.00504731
75YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00401185
76TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.00029070
77P300_19829295_ChIP-Seq_ESCs_Human0.98827829
78* RNF2_27304074_Chip-Seq_NSC_Mouse0.98137862
79ARNT_22903824_ChIP-Seq_MCF-7_Human0.97586495
80TP53_16413492_ChIP-PET_HCT116_Human0.97314125
81KDM2B_26808549_Chip-Seq_SUP-B15_Human0.96555381
82* TP53_20018659_ChIP-ChIP_R1E_Mouse0.94922673
83PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94811698
84CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.94759610
85ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.94623108
86P53_22127205_ChIP-Seq_FIBROBLAST_Human0.94094631
87KDM2B_26808549_Chip-Seq_JURKAT_Human0.93748940
88TCF4_23295773_ChIP-Seq_U87_Human0.93583267
89* CBX2_27304074_Chip-Seq_ESCs_Mouse0.93447615
90SMAD_19615063_ChIP-ChIP_OVARY_Human0.93399795
91SMAD3_21741376_ChIP-Seq_HESCs_Human0.92846051
92MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92316949
93AHR_22903824_ChIP-Seq_MCF-7_Human0.92201732
94TRIM28_21343339_ChIP-Seq_HEK293_Human0.92100728
95OCT4_19829295_ChIP-Seq_ESCs_Human0.91575854
96UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.91010005
97SMAD3_21741376_ChIP-Seq_ESCs_Human0.90736528
98DPY_21335234_ChIP-Seq_ESCs_Mouse0.90606473
99* CTCF_27219007_Chip-Seq_Bcells_Human0.90528981
100RXR_22108803_ChIP-Seq_LS180_Human0.90208926
101SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.90159652
102RUNX1_26923725_Chip-Seq_HPCs_Mouse0.90013732
103OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89816622
104EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.89686529
105* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.89625986
106TOP2B_26459242_ChIP-Seq_MCF-7_Human0.88668298
107* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.88135492
108TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.87171650
109* SMAD4_21741376_ChIP-Seq_HESCs_Human0.86655237
110VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.85818960
111MYC_19915707_ChIP-ChIP_AK7_Human0.85049163
112SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.84536709
113ZFP57_27257070_Chip-Seq_ESCs_Mouse0.84456957
114TP53_23651856_ChIP-Seq_MEFs_Mouse0.84323051
115* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.83900805
116ZNF263_19887448_ChIP-Seq_K562_Human0.82861753
117DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.82852584
118KLF4_19829295_ChIP-Seq_ESCs_Human0.82119441
119PIAS1_25552417_ChIP-Seq_VCAP_Human0.81935839
120P68_20966046_ChIP-Seq_HELA_Human0.81711558
121SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81570636
122* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.81506069
123TAF15_26573619_Chip-Seq_HEK293_Human0.80405613
124POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.80289271
125TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80289271
126NR3C1_21868756_ChIP-Seq_MCF10A_Human0.79598645
127SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.79557697
128CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.79433821
129* LXR_22292898_ChIP-Seq_THP-1_Human0.79117482
130* BMI1_23680149_ChIP-Seq_NPCS_Mouse0.78961474
131SOX9_26525672_Chip-Seq_HEART_Mouse0.76304949
132GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.75579940
133SMAD4_21741376_ChIP-Seq_ESCs_Human0.73661635
134MITF_21258399_ChIP-Seq_MELANOMA_Human0.71749156

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.73139004
2MP0003635_abnormal_synaptic_transmissio4.47404167
3MP0003880_abnormal_central_pattern4.45934927
4MP0009046_muscle_twitch3.65502687
5MP0004270_analgesia3.63460603
6MP0002063_abnormal_learning/memory/cond3.52133240
7MP0009745_abnormal_behavioral_response3.51135099
8MP0002064_seizures3.37994441
9MP0002572_abnormal_emotion/affect_behav2.89971365
10MP0001968_abnormal_touch/_nociception2.86538063
11MP0002272_abnormal_nervous_system2.78281900
12MP0008569_lethality_at_weaning2.50039801
13MP0002734_abnormal_mechanical_nocicepti2.48883825
14MP0001486_abnormal_startle_reflex2.44004525
15MP0002735_abnormal_chemical_nociception2.42064067
16MP0005423_abnormal_somatic_nervous2.37572077
17MP0001501_abnormal_sleep_pattern2.36652850
18MP0001440_abnormal_grooming_behavior2.35140311
19MP0002736_abnormal_nociception_after2.34623153
20MP0002067_abnormal_sensory_capabilities2.14166932
21MP0004858_abnormal_nervous_system2.08037213
22MP0003329_amyloid_beta_deposits2.06444694
23MP0002733_abnormal_thermal_nociception1.96206089
24MP0001970_abnormal_pain_threshold1.92417827
25* MP0002184_abnormal_innervation1.83348560
26MP0004811_abnormal_neuron_physiology1.80110796
27MP0003879_abnormal_hair_cell1.76226707
28MP0000778_abnormal_nervous_system1.72452801
29MP0002557_abnormal_social/conspecific_i1.67451105
30MP0000955_abnormal_spinal_cord1.63755486
31MP0009780_abnormal_chondrocyte_physiolo1.62282566
32MP0002822_catalepsy1.58000439
33MP0001348_abnormal_lacrimal_gland1.55650548
34MP0003123_paternal_imprinting1.53300268
35MP0004924_abnormal_behavior1.51556617
36MP0005386_behavior/neurological_phenoty1.51556617
37MP0004885_abnormal_endolymph1.51042596
38MP0002066_abnormal_motor_capabilities/c1.50506427
39MP0004145_abnormal_muscle_electrophysio1.50225727
40MP0002909_abnormal_adrenal_gland1.46725302
41MP0003633_abnormal_nervous_system1.45978455
42MP0002882_abnormal_neuron_morphology1.45224461
43MP0004142_abnormal_muscle_tone1.44119766
44MP0001502_abnormal_circadian_rhythm1.31717278
45MP0003631_nervous_system_phenotype1.29659673
46MP0004147_increased_porphyrin_level1.24075680
47MP0006276_abnormal_autonomic_nervous1.18129382
48MP0003787_abnormal_imprinting1.16855432
49MP0002152_abnormal_brain_morphology1.15887472
50MP0001984_abnormal_olfaction1.15111123
51MP0005646_abnormal_pituitary_gland1.13529068
52MP0003075_altered_response_to1.13403479
53MP0005645_abnormal_hypothalamus_physiol1.12889043
54MP0001346_abnormal_lacrimal_gland1.12680353
55MP0003632_abnormal_nervous_system1.11201805
56MP0000751_myopathy1.06612539
57MP0003283_abnormal_digestive_organ1.06528401
58MP0003122_maternal_imprinting1.02181659
59MP0001188_hyperpigmentation0.97497419
60MP0000604_amyloidosis0.95027521
61MP0004742_abnormal_vestibular_system0.94196445
62MP0008872_abnormal_physiological_respon0.92870030
63MP0002069_abnormal_eating/drinking_beha0.91964659
64MP0000579_abnormal_nail_morphology0.91574586
65MP0003690_abnormal_glial_cell0.91015715
66MP0004510_myositis0.90861264
67MP0002229_neurodegeneration0.90612677
68MP0004233_abnormal_muscle_weight0.88776968
69MP0008874_decreased_physiological_sensi0.86994614
70MP0001177_atelectasis0.86905678
71MP0000569_abnormal_digit_pigmentation0.86266694
72MP0001905_abnormal_dopamine_level0.85711937
73MP0003634_abnormal_glial_cell0.84991279
74MP0008961_abnormal_basal_metabolism0.84030538
75MP0005171_absent_coat_pigmentation0.82899609
76MP0001963_abnormal_hearing_physiology0.82169964
77MP0000920_abnormal_myelination0.81159347
78MP0005409_darkened_coat_color0.80903192
79MP0001485_abnormal_pinna_reflex0.80088883
80MP0005623_abnormal_meninges_morphology0.78857754
81MP0010234_abnormal_vibrissa_follicle0.76574666
82MP0001986_abnormal_taste_sensitivity0.74982075
83MP0003172_abnormal_lysosome_physiology0.72994935
84MP0010386_abnormal_urinary_bladder0.72951646
85MP0004215_abnormal_myocardial_fiber0.72208675
86MP0004484_altered_response_of0.71962443
87MP0004085_abnormal_heartbeat0.71848696
88MP0003137_abnormal_impulse_conducting0.71438399
89MP0002752_abnormal_somatic_nervous0.69820122
90MP0005535_abnormal_body_temperature0.66557221
91MP0005167_abnormal_blood-brain_barrier0.63237462
92MP0003045_fibrosis0.63106129
93MP0000013_abnormal_adipose_tissue0.62463596
94* MP0005551_abnormal_eye_electrophysiolog0.61817079
95MP0002638_abnormal_pupillary_reflex0.61134610
96MP0010769_abnormal_survival0.60965550
97MP0002089_abnormal_postnatal_growth/wei0.60645585
98MP0003861_abnormal_nervous_system0.59888785
99MP0004043_abnormal_pH_regulation0.59101944
100MP0001299_abnormal_eye_distance/0.58206266
101MP0002090_abnormal_vision0.57975354
102MP0010768_mortality/aging0.57861241
103MP0002082_postnatal_lethality0.55015124
104MP0010770_preweaning_lethality0.55015124
105MP0001943_abnormal_respiration0.54014138
106MP0002653_abnormal_ependyma_morphology0.53219448
107MP0003956_abnormal_body_size0.51483968
108MP0000747_muscle_weakness0.50569798
109MP0001664_abnormal_digestion0.50112752
110MP0000003_abnormal_adipose_tissue0.50010445
111MP0009672_abnormal_birth_weight0.46852784
112MP0002249_abnormal_larynx_morphology0.46723891
113MP0004130_abnormal_muscle_cell0.46163771
114MP0008877_abnormal_DNA_methylation0.45879849
115MP0002873_normal_phenotype0.45166694
116MP0002169_no_abnormal_phenotype0.43302733
117MP0003705_abnormal_hypodermis_morpholog0.43249263

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.58027383
2Myokymia (HP:0002411)7.10832679
3Focal seizures (HP:0007359)5.89494623
4Progressive cerebellar ataxia (HP:0002073)5.78964484
5Visual hallucinations (HP:0002367)5.78667580
6Action tremor (HP:0002345)5.48176133
7Atonic seizures (HP:0010819)5.07822608
8Epileptic encephalopathy (HP:0200134)4.73904967
9Febrile seizures (HP:0002373)4.67097338
10Gaze-evoked nystagmus (HP:0000640)4.33720645
11Absence seizures (HP:0002121)4.29932581
12Abnormality of the lower motor neuron (HP:0002366)4.17140167
13Dialeptic seizures (HP:0011146)3.93730750
14Dysdiadochokinesis (HP:0002075)3.88905211
15Cerebral hypomyelination (HP:0006808)3.77748162
16Generalized tonic-clonic seizures (HP:0002069)3.76170417
17Dysmetria (HP:0001310)3.70332099
18Impaired smooth pursuit (HP:0007772)3.63146107
19Broad-based gait (HP:0002136)3.48727885
20Genetic anticipation (HP:0003743)3.47724832
21Scanning speech (HP:0002168)3.47216297
22Dysmetric saccades (HP:0000641)3.44874987
23Truncal ataxia (HP:0002078)3.33055617
24Annular pancreas (HP:0001734)3.32109522
25Supranuclear gaze palsy (HP:0000605)3.30338529
26Abnormality of ocular smooth pursuit (HP:0000617)3.28430612
27Depression (HP:0000716)3.27436832
28Intention tremor (HP:0002080)3.25105854
29Hemiplegia (HP:0002301)3.24198025
30Impaired vibration sensation in the lower limbs (HP:0002166)3.21614707
31Poor eye contact (HP:0000817)3.21576441
32Ventricular fibrillation (HP:0001663)3.04384073
33Abnormal social behavior (HP:0012433)2.92976223
34Impaired social interactions (HP:0000735)2.92976223
35Abnormal eating behavior (HP:0100738)2.92741142
36Hemiparesis (HP:0001269)2.91917310
37Limb dystonia (HP:0002451)2.88843322
38Postural instability (HP:0002172)2.87793235
39Amblyopia (HP:0000646)2.81903421
40Anxiety (HP:0000739)2.79803467
41Diplopia (HP:0000651)2.78449700
42Abnormality of binocular vision (HP:0011514)2.78449700
43Ankle clonus (HP:0011448)2.77812506
44Akinesia (HP:0002304)2.76770288
45Status epilepticus (HP:0002133)2.59922212
46Mutism (HP:0002300)2.57218962
47Urinary bladder sphincter dysfunction (HP:0002839)2.55912766
48Stereotypic behavior (HP:0000733)2.48625192
49Fetal akinesia sequence (HP:0001989)2.44088840
50Choreoathetosis (HP:0001266)2.43437064
51Hyperventilation (HP:0002883)2.40117893
52Bundle branch block (HP:0011710)2.37277198
53Excessive salivation (HP:0003781)2.37093657
54Drooling (HP:0002307)2.37093657
55Papilledema (HP:0001085)2.32507008
56Epileptiform EEG discharges (HP:0011182)2.31709697
57Pointed chin (HP:0000307)2.30927096
58Spastic gait (HP:0002064)2.29358844
59Impaired vibratory sensation (HP:0002495)2.28134573
60Urinary urgency (HP:0000012)2.27556462
61Bradykinesia (HP:0002067)2.25500555
62Abnormality of saccadic eye movements (HP:0000570)2.24106027
63Apathy (HP:0000741)2.23480608
64Gait ataxia (HP:0002066)2.19994313
65CNS hypomyelination (HP:0003429)2.16339378
66Focal dystonia (HP:0004373)2.14222009
67Lower limb asymmetry (HP:0100559)2.14032791
68Agitation (HP:0000713)2.12994619
69Spastic tetraparesis (HP:0001285)2.12779778
70Postural tremor (HP:0002174)2.12397002
71Limb ataxia (HP:0002070)2.11761929
72Torticollis (HP:0000473)2.11027437
73Incomplete penetrance (HP:0003829)2.11004880
74EEG with generalized epileptiform discharges (HP:0011198)2.10982351
75Cerebral inclusion bodies (HP:0100314)2.10759605
76Lower limb amyotrophy (HP:0007210)2.10210218
77Sleep apnea (HP:0010535)2.09583582
78Tetraplegia (HP:0002445)2.06279894
79Horizontal nystagmus (HP:0000666)2.06011640
80Megalencephaly (HP:0001355)2.04496639
81Absent speech (HP:0001344)2.00812357
82Generalized myoclonic seizures (HP:0002123)2.00357978
83Neurofibrillary tangles (HP:0002185)1.99372067
84Hypsarrhythmia (HP:0002521)1.99235487
85Peripheral hypomyelination (HP:0007182)1.98461096
86Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.96816603
87Degeneration of the lateral corticospinal tracts (HP:0002314)1.96816603
88Insomnia (HP:0100785)1.96675054
89Diminished motivation (HP:0000745)1.93674575
90Obstructive sleep apnea (HP:0002870)1.92297516
91Neuronal loss in central nervous system (HP:0002529)1.84889325
92Mild short stature (HP:0003502)1.84581539
93Spinal canal stenosis (HP:0003416)1.82765045
94Morphological abnormality of the pyramidal tract (HP:0002062)1.80588973
95Abnormality of the periventricular white matter (HP:0002518)1.80147047
96Aplasia involving bones of the extremities (HP:0009825)1.78988090
97Aplasia involving bones of the upper limbs (HP:0009823)1.78988090
98Aplasia of the phalanges of the hand (HP:0009802)1.78988090
99Rapidly progressive (HP:0003678)1.78076684
100Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.77894609
101Amyotrophic lateral sclerosis (HP:0007354)1.77301760
102Increased circulating renin level (HP:0000848)1.77148461
103Clonus (HP:0002169)1.76788968
104Bronchomalacia (HP:0002780)1.76261873
105Psychosis (HP:0000709)1.76122961
106Termporal pattern (HP:0011008)1.74788685
107Insidious onset (HP:0003587)1.74788685
108Abnormality of the corticospinal tract (HP:0002492)1.74181349
109Lower limb muscle weakness (HP:0007340)1.73477086
110Pheochromocytoma (HP:0002666)1.72622161
111Aqueductal stenosis (HP:0002410)1.71867923
112Progressive inability to walk (HP:0002505)1.71027676
113Slow saccadic eye movements (HP:0000514)1.70837942
114Craniofacial dystonia (HP:0012179)1.66477294
115Abnormal EKG (HP:0003115)1.66212183
116Delusions (HP:0000746)1.65306771
117Neoplasm of the heart (HP:0100544)1.64618905
118Rigidity (HP:0002063)1.64411488
119Turricephaly (HP:0000262)1.64252366
120Slow progression (HP:0003677)1.59342786

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.86194349
2MAP3K94.12476734
3EPHA43.90973110
4MINK12.60019320
5PAK62.55456684
6MAP3K42.48603850
7DAPK22.47500922
8KSR22.36378813
9PRKD32.25148275
10CAMKK12.10220376
11NTRK21.99332954
12PRPF4B1.93843180
13MAP2K71.91421747
14STK381.78916246
15KSR11.78133198
16DAPK11.77734793
17MARK11.75445859
18MAP2K41.74704666
19RIPK41.71210413
20CDK191.68465389
21PDK21.68419856
22CAMKK21.68070852
23TYRO31.60000237
24MAP3K131.55170460
25CDK51.52353335
26ARAF1.51322177
27NTRK11.47850355
28PLK21.43867391
29MAP3K121.42717915
30UHMK11.42706852
31PRKCG1.30724831
32TNIK1.28083780
33CAMK11.27262070
34GRK51.24547023
35RIPK11.20334586
36PINK11.17184900
37MAP3K21.14023826
38PTK2B1.10906690
39CDK181.07195536
40CDK151.06504117
41FES1.04780684
42CAMK2A1.03271267
43CAMK2B1.02647296
44BRSK11.01618216
45RAF11.01612991
46SIK20.98092706
47MAPK130.96041431
48CDK140.95477132
49ALK0.94282280
50PRKCH0.94215772
51CDK11A0.93653161
52MAPK120.88790715
53DDR20.86965110
54PNCK0.86006683
55MARK20.85570634
56STK110.83845612
57SGK4940.81791453
58SGK2230.81791453
59ICK0.79651384
60LATS20.77638967
61PDK10.76455611
62BRAF0.75772057
63DYRK1A0.74535559
64CASK0.74449896
65EEF2K0.74237441
66LMTK20.73780292
67WNK10.72742513
68PHKG20.72647212
69PHKG10.72647212
70OXSR10.72249793
71SGK10.71449591
72CAMK40.70646285
73RET0.70346837
74PAK30.70027988
75SGK20.69898383
76TAOK10.69687263
77SGK30.69337719
78MAP3K10.67765706
79CDC42BPA0.67586133
80PDPK10.65387482
81FGR0.63035601
82CAMK2G0.62640676
83MAP3K70.62139597
84FER0.61554350
85BMX0.59848542
86DAPK30.58690838
87RPS6KA30.54991406
88CAMK2D0.54815630
89PKN10.50800955
90MAP3K60.50627456
91BMPR20.50456853
92CAMK1G0.45675201
93MOS0.45041045
94DMPK0.44847242
95WNK30.44549094
96TNK20.44532788
97MAPK100.44471787
98PRKCZ0.44460488
99NEK60.44163964
100MAPKAPK50.44072771
101ROCK20.43435063
102LIMK10.43260681
103PRKD20.42799943
104FGFR20.42330991
105FYN0.42088270
106TAOK20.40645243
107WNK40.39358330
108PDGFRA0.39077161
109MAP2K10.37710704
110CSNK1G20.36551502
111CDK120.36478654
112TRIB30.34800185
113NEK10.34594176
114STK390.34579806
115IRAK20.34274369
116PTK20.34256863
117PRKG20.31018562
118CSNK1E0.30814477
119MAPK80.30776070
120GSK3B0.30399263
121PRKCA0.30067069
122RPS6KB10.29531982
123SCYL20.27427014
124TESK10.26409248

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.98221624
2Synaptic vesicle cycle_Homo sapiens_hsa047213.09547959
3Long-term potentiation_Homo sapiens_hsa047202.95986964
4Circadian entrainment_Homo sapiens_hsa047132.79734045
5Glutamatergic synapse_Homo sapiens_hsa047242.78338413
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.72171380
7GABAergic synapse_Homo sapiens_hsa047272.52659058
8Amphetamine addiction_Homo sapiens_hsa050312.45531346
9Olfactory transduction_Homo sapiens_hsa047402.45530375
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.29712306
11Salivary secretion_Homo sapiens_hsa049702.29331727
12Morphine addiction_Homo sapiens_hsa050322.29151913
13Insulin secretion_Homo sapiens_hsa049112.02657743
14Gastric acid secretion_Homo sapiens_hsa049712.01384285
15Aldosterone synthesis and secretion_Homo sapiens_hsa049251.97333899
16Long-term depression_Homo sapiens_hsa047301.97274731
17Dopaminergic synapse_Homo sapiens_hsa047281.96824668
18Taste transduction_Homo sapiens_hsa047421.84611638
19Cholinergic synapse_Homo sapiens_hsa047251.79023391
20Oxytocin signaling pathway_Homo sapiens_hsa049211.72456519
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.68700620
22Vitamin B6 metabolism_Homo sapiens_hsa007501.66468229
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.66302892
24Calcium signaling pathway_Homo sapiens_hsa040201.64947456
25GnRH signaling pathway_Homo sapiens_hsa049121.56616956
26Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.54508596
27Renin secretion_Homo sapiens_hsa049241.41281908
28Serotonergic synapse_Homo sapiens_hsa047261.39748656
29Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.34539711
30Phosphatidylinositol signaling system_Homo sapiens_hsa040701.33816938
31cAMP signaling pathway_Homo sapiens_hsa040241.33332619
32Gap junction_Homo sapiens_hsa045401.29707593
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.25375034
34Type II diabetes mellitus_Homo sapiens_hsa049301.23723103
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.23006643
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.21963411
37Estrogen signaling pathway_Homo sapiens_hsa049151.20674471
38Cocaine addiction_Homo sapiens_hsa050301.20329234
39Glioma_Homo sapiens_hsa052141.18369023
40Nitrogen metabolism_Homo sapiens_hsa009101.17367075
41Collecting duct acid secretion_Homo sapiens_hsa049661.10893294
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06512066
43Melanogenesis_Homo sapiens_hsa049161.03300089
44Pancreatic secretion_Homo sapiens_hsa049721.02860219
45ErbB signaling pathway_Homo sapiens_hsa040121.02381920
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.00549346
47Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.96448494
48Axon guidance_Homo sapiens_hsa043600.95954230
49Oocyte meiosis_Homo sapiens_hsa041140.95349618
50Dorso-ventral axis formation_Homo sapiens_hsa043200.94593509
51Thyroid hormone synthesis_Homo sapiens_hsa049180.93447030
52Phospholipase D signaling pathway_Homo sapiens_hsa040720.92910590
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.91383671
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88672348
55Arginine biosynthesis_Homo sapiens_hsa002200.83602382
56Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.83159030
57Choline metabolism in cancer_Homo sapiens_hsa052310.82667186
58Cardiac muscle contraction_Homo sapiens_hsa042600.80920673
59VEGF signaling pathway_Homo sapiens_hsa043700.78573301
60Dilated cardiomyopathy_Homo sapiens_hsa054140.74410159
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74180967
62MAPK signaling pathway_Homo sapiens_hsa040100.72564231
63Vibrio cholerae infection_Homo sapiens_hsa051100.68812512
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.67142180
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66338937
66mTOR signaling pathway_Homo sapiens_hsa041500.65221960
67Inositol phosphate metabolism_Homo sapiens_hsa005620.62815085
68Bile secretion_Homo sapiens_hsa049760.62722442
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60872163
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58071739
71Circadian rhythm_Homo sapiens_hsa047100.57906667
72Glucagon signaling pathway_Homo sapiens_hsa049220.56365275
73Rap1 signaling pathway_Homo sapiens_hsa040150.56021490
74Alcoholism_Homo sapiens_hsa050340.51919260
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.51294585
76Endocytosis_Homo sapiens_hsa041440.50946651
77Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50287216
78Ras signaling pathway_Homo sapiens_hsa040140.48999783
79Wnt signaling pathway_Homo sapiens_hsa043100.48866293
80Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46747546
81Biosynthesis of amino acids_Homo sapiens_hsa012300.45553819
82Arginine and proline metabolism_Homo sapiens_hsa003300.44508573
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44282900
84Non-small cell lung cancer_Homo sapiens_hsa052230.41026892
85Fatty acid biosynthesis_Homo sapiens_hsa000610.40636778
86Phototransduction_Homo sapiens_hsa047440.40050484
87Central carbon metabolism in cancer_Homo sapiens_hsa052300.39676902
88Endometrial cancer_Homo sapiens_hsa052130.38366965
89Prion diseases_Homo sapiens_hsa050200.38244046
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38165164
91Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36727103
92Hippo signaling pathway_Homo sapiens_hsa043900.35413206
93Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.34980508
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34978054
95Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.34437703
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33601755
97African trypanosomiasis_Homo sapiens_hsa051430.33139858
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.32054052
99AMPK signaling pathway_Homo sapiens_hsa041520.32016305
100Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31542563
101Insulin signaling pathway_Homo sapiens_hsa049100.30931179
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30485827
103Alzheimers disease_Homo sapiens_hsa050100.29110043
104Mineral absorption_Homo sapiens_hsa049780.28418501
105Ovarian steroidogenesis_Homo sapiens_hsa049130.28351505
106Chemokine signaling pathway_Homo sapiens_hsa040620.27890063
107Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27025693
108Renal cell carcinoma_Homo sapiens_hsa052110.26996206
109Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.26735434
110HIF-1 signaling pathway_Homo sapiens_hsa040660.26399184
111Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.25983774
112Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.25675237
113Tight junction_Homo sapiens_hsa045300.19127593
114Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.18794825

Most similar genes based on co-expression Upload to Enrichr

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