NPTN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a type I transmembrane protein belonging to the Ig superfamily. The protein is believed to be involved in cell-cell interactions or cell-substrate interactions. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.54230250
2vocalization behavior (GO:0071625)5.24620670
3synaptic vesicle exocytosis (GO:0016079)5.17307953
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.09077543
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.08333823
6neuronal action potential propagation (GO:0019227)5.03460610
7synaptic vesicle maturation (GO:0016188)4.96209500
8ionotropic glutamate receptor signaling pathway (GO:0035235)4.90655081
9locomotory exploration behavior (GO:0035641)4.86616294
10glutamate secretion (GO:0014047)4.80560850
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.77905299
12regulation of glutamate receptor signaling pathway (GO:1900449)4.68697733
13glutamate receptor signaling pathway (GO:0007215)4.59648269
14protein localization to synapse (GO:0035418)4.58183132
15regulation of synaptic vesicle exocytosis (GO:2000300)4.57845800
16neuron cell-cell adhesion (GO:0007158)4.37917545
17synaptic vesicle docking involved in exocytosis (GO:0016081)4.26643510
18regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.23065682
19gamma-aminobutyric acid signaling pathway (GO:0007214)4.18983650
20neuron-neuron synaptic transmission (GO:0007270)4.16011321
21synaptic transmission, glutamatergic (GO:0035249)4.14762460
22regulation of synaptic vesicle transport (GO:1902803)4.13110277
23neurotransmitter secretion (GO:0007269)4.12847173
24exploration behavior (GO:0035640)4.11133472
25negative regulation of synaptic transmission, GABAergic (GO:0032229)4.05528081
26* regulation of long-term neuronal synaptic plasticity (GO:0048169)4.01104926
27cellular potassium ion homeostasis (GO:0030007)3.92369302
28regulation of excitatory postsynaptic membrane potential (GO:0060079)3.87176865
29cell communication by electrical coupling (GO:0010644)3.86198110
30* regulation of neuronal synaptic plasticity (GO:0048168)3.83683661
31neurotransmitter-gated ion channel clustering (GO:0072578)3.78220043
32neuron recognition (GO:0008038)3.73665496
33regulation of synapse structural plasticity (GO:0051823)3.73121633
34gamma-aminobutyric acid transport (GO:0015812)3.71639341
35regulation of postsynaptic membrane potential (GO:0060078)3.66322025
36membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.66033334
37long-term memory (GO:0007616)3.64196223
38proline transport (GO:0015824)3.62586179
39cytoskeletal anchoring at plasma membrane (GO:0007016)3.62495912
40protein localization to endosome (GO:0036010)3.57072154
41response to histamine (GO:0034776)3.53293646
42layer formation in cerebral cortex (GO:0021819)3.52262248
43G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.52155968
44positive regulation of synapse maturation (GO:0090129)3.51552080
45regulation of dendritic spine morphogenesis (GO:0061001)3.50669285
46* regulation of synaptic plasticity (GO:0048167)3.49669894
47regulation of vesicle fusion (GO:0031338)3.44123176
48neurotransmitter transport (GO:0006836)3.40771841
49regulation of synaptic transmission, glutamatergic (GO:0051966)3.40031767
50* long-term synaptic potentiation (GO:0060291)3.39077340
51positive regulation of membrane potential (GO:0045838)3.37627335
52synaptic vesicle endocytosis (GO:0048488)3.35902888
53axonal fasciculation (GO:0007413)3.34815597
54transmission of nerve impulse (GO:0019226)3.34275289
55dendritic spine morphogenesis (GO:0060997)3.32499997
56G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.31530056
57positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.22650550
58presynaptic membrane assembly (GO:0097105)3.22527133
59behavioral fear response (GO:0001662)3.22498610
60behavioral defense response (GO:0002209)3.22498610
61activation of protein kinase A activity (GO:0034199)3.21672459
62regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.20464405
63sodium ion export (GO:0071436)3.20359329
64regulation of neurotransmitter secretion (GO:0046928)3.18877390
65positive regulation of neurotransmitter secretion (GO:0001956)3.18263278
66regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.17316422
67regulation of neurotransmitter levels (GO:0001505)3.13140094
68fear response (GO:0042596)3.12890759
69long term synaptic depression (GO:0060292)3.12086684
70postsynaptic membrane organization (GO:0001941)3.12039433
71cerebellar granule cell differentiation (GO:0021707)3.11867811
72behavioral response to cocaine (GO:0048148)3.11594678
73regulation of glutamate secretion (GO:0014048)3.11499861
74cerebellar Purkinje cell differentiation (GO:0021702)3.11418984
75regulation of dendritic spine development (GO:0060998)3.11330543
76membrane depolarization (GO:0051899)3.11171605
77positive regulation of neurotransmitter transport (GO:0051590)3.09867549
78neuromuscular process controlling balance (GO:0050885)3.08394301
79positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.06556520
80presynaptic membrane organization (GO:0097090)3.03635053
81learning (GO:0007612)3.01539635
82positive regulation of vesicle fusion (GO:0031340)3.01085783
83potassium ion homeostasis (GO:0055075)3.00554912
84vesicle transport along microtubule (GO:0047496)2.97644089
85regulation of neurotransmitter transport (GO:0051588)2.96466790
86mating behavior (GO:0007617)2.96102928
87detection of calcium ion (GO:0005513)2.94603074
88synaptic transmission (GO:0007268)2.94333481
89cell adhesion mediated by integrin (GO:0033627)2.94145980
90regulation of voltage-gated calcium channel activity (GO:1901385)2.93460293
91cellular sodium ion homeostasis (GO:0006883)2.92032288
92membrane depolarization during action potential (GO:0086010)2.90996079
93regulation of female receptivity (GO:0045924)2.90531354
94regulation of ARF protein signal transduction (GO:0032012)2.89901799
95cell communication involved in cardiac conduction (GO:0086065)2.89146456
96synapse assembly (GO:0007416)2.88925453
97* regulation of synaptic transmission (GO:0050804)2.87824790
98cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.86282699
99innervation (GO:0060384)2.85633317
100amino acid import (GO:0043090)2.84881981
101neuromuscular process controlling posture (GO:0050884)2.84546389
102positive regulation of synaptic transmission, GABAergic (GO:0032230)2.83572241
103negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.81403473
104regulation of early endosome to late endosome transport (GO:2000641)2.81029257
105* positive regulation of synaptic transmission (GO:0050806)2.80817855
106negative regulation of amino acid transport (GO:0051956)2.80583596
107startle response (GO:0001964)2.78165856
108response to auditory stimulus (GO:0010996)2.77020920
109regulation of synaptic transmission, GABAergic (GO:0032228)2.76281606
110female mating behavior (GO:0060180)2.76051662
111regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.76004699
112L-amino acid import (GO:0043092)2.75885542
113negative regulation of dendrite morphogenesis (GO:0050774)2.67941475
114regulation of clathrin-mediated endocytosis (GO:2000369)2.66419187
115desmosome organization (GO:0002934)2.61307500
116skin morphogenesis (GO:0043589)2.55584411
117stress fiber assembly (GO:0043149)2.48082239
118endocytic recycling (GO:0032456)2.41856707
119COPI coating of Golgi vesicle (GO:0048205)2.41664944
120Golgi transport vesicle coating (GO:0048200)2.41664944
121hemidesmosome assembly (GO:0031581)2.41302379
122vesicle docking involved in exocytosis (GO:0006904)2.40933322
123relaxation of cardiac muscle (GO:0055119)2.40406971
124regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.40052563
125potassium ion import (GO:0010107)2.37725766
126vesicle docking (GO:0048278)2.35390529
127protein retention in ER lumen (GO:0006621)2.35184975
128positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.30833112
129barbed-end actin filament capping (GO:0051016)2.30678385
130negative regulation of protein localization to plasma membrane (GO:1903077)2.29326395
131positive regulation of receptor recycling (GO:0001921)2.24727731
132positive regulation of fibroblast migration (GO:0010763)2.20077963
133maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.19431824
134cell-substrate junction assembly (GO:0007044)2.17623505
135regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.17209019
136negative regulation of hormone biosynthetic process (GO:0032353)2.17156061
137cellular copper ion homeostasis (GO:0006878)2.16717870
138regulation of transforming growth factor beta1 production (GO:0032908)2.15255868
139regulation of integrin-mediated signaling pathway (GO:2001044)2.14733286
140positive regulation of nitric-oxide synthase activity (GO:0051000)2.11758460
141clathrin coat assembly (GO:0048268)2.10863371
142transferrin transport (GO:0033572)2.10326687
143regulation of glucocorticoid metabolic process (GO:0031943)2.06120248
144regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.05298314
145positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.05226515
146actin filament depolymerization (GO:0030042)2.04552605
147positive regulation of exocytosis (GO:0045921)2.04134298
148negative regulation of homotypic cell-cell adhesion (GO:0034111)2.03451216
149cerebellar Purkinje cell layer development (GO:0021680)2.02572448
150cortical actin cytoskeleton organization (GO:0030866)2.01565402
151positive regulation of dendritic spine development (GO:0060999)2.00655549
152negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)1.99992942
153positive regulation of protein dephosphorylation (GO:0035307)1.99989353

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.79074591
2GBX2_23144817_ChIP-Seq_PC3_Human3.74585037
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.25017685
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.21787091
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.07115480
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.93898684
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.82059313
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.78660530
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.78660530
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.64597666
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.63845790
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.60877352
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.60359156
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.54322320
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.47369931
16REST_21632747_ChIP-Seq_MESCs_Mouse2.46792487
17RARB_27405468_Chip-Seq_BRAIN_Mouse2.43421561
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.37210430
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.35250978
20IKZF1_21737484_ChIP-ChIP_HCT116_Human2.31118634
21PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.27734260
22DROSHA_22980978_ChIP-Seq_HELA_Human2.15456086
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.12171226
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.10637667
25ESR2_21235772_ChIP-Seq_MCF-7_Human2.09112285
26EZH2_27294783_Chip-Seq_ESCs_Mouse2.06862727
27TAF15_26573619_Chip-Seq_HEK293_Human2.03923609
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.00480649
29REST_18959480_ChIP-ChIP_MESCs_Mouse1.97943057
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.93462979
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.84604928
32TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.84294385
33NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.84098167
34AR_21572438_ChIP-Seq_LNCaP_Human1.83517199
35RARG_19884340_ChIP-ChIP_MEFs_Mouse1.82547612
36CLOCK_20551151_ChIP-Seq_293T_Human1.77585992
37SMAD4_21799915_ChIP-Seq_A2780_Human1.76806762
38MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.71358443
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.69002482
40EP300_21415370_ChIP-Seq_HL-1_Mouse1.67746772
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.66114352
42ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.61770003
43P300_19829295_ChIP-Seq_ESCs_Human1.57117205
44* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.56786685
45ESR1_21235772_ChIP-Seq_MCF-7_Human1.56683957
46Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.55663312
47GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.55104121
48NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.54494374
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.52227738
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50535595
51CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.48526802
52TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.43637154
53ERG_21242973_ChIP-ChIP_JURKAT_Human1.42342714
54PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.40840652
55NR3C1_23031785_ChIP-Seq_PC12_Mouse1.37875839
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37135444
57CDX2_19796622_ChIP-Seq_MESCs_Mouse1.36838203
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.36736931
59ZNF274_21170338_ChIP-Seq_K562_Hela1.36562354
60TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36552206
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36509804
62AR_25329375_ChIP-Seq_VCAP_Human1.35433949
63* SOX2_20726797_ChIP-Seq_SW620_Human1.35376089
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.35178161
65GATA2_21666600_ChIP-Seq_HMVEC_Human1.33036547
66EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32667947
67KDM2B_26808549_Chip-Seq_K562_Human1.32322875
68SOX2_21211035_ChIP-Seq_LN229_Gbm1.32173229
69OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31067205
70POU3F2_20337985_ChIP-ChIP_501MEL_Human1.30679609
71RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.29383400
72* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.29127377
73TP53_16413492_ChIP-PET_HCT116_Human1.29015683
74BMI1_23680149_ChIP-Seq_NPCS_Mouse1.26707195
75SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26665914
76SOX9_24532713_ChIP-Seq_HFSC_Mouse1.25027965
77TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23258225
78WT1_19549856_ChIP-ChIP_CCG9911_Human1.22005776
79FUS_26573619_Chip-Seq_HEK293_Human1.21386889
80ZNF217_24962896_ChIP-Seq_MCF-7_Human1.21349573
81STAT3_23295773_ChIP-Seq_U87_Human1.21217884
82RING1B_27294783_Chip-Seq_ESCs_Mouse1.20082815
83TP53_18474530_ChIP-ChIP_U2OS_Human1.19564326
84VDR_22108803_ChIP-Seq_LS180_Human1.18634213
85TET1_21490601_ChIP-Seq_MESCs_Mouse1.17490050
86SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.17318089
87CBX2_27304074_Chip-Seq_ESCs_Mouse1.16034639
88CTNNB1_20460455_ChIP-Seq_HCT116_Human1.14760199
89AR_19668381_ChIP-Seq_PC3_Human1.14553088
90CJUN_26792858_Chip-Seq_BT549_Human1.14396375
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14382304
92ZFP281_18757296_ChIP-ChIP_E14_Mouse1.14358229
93TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14260081
94ARNT_22903824_ChIP-Seq_MCF-7_Human1.13754880
95* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.11536875
96SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.10853029
97CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.10789914
98ESR1_20079471_ChIP-ChIP_T-47D_Human1.09801139
99AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09661796
100PRDM14_20953172_ChIP-Seq_ESCs_Human1.08048392
101AHR_22903824_ChIP-Seq_MCF-7_Human1.08030803
102WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06568870
103ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.06370118
104RUNX2_22187159_ChIP-Seq_PCA_Human1.06184171
105TCF4_23295773_ChIP-Seq_U87_Human1.05736395
106BCAT_22108803_ChIP-Seq_LS180_Human1.05145693
107SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.04751626
108* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.04496611
109IGF1R_20145208_ChIP-Seq_DFB_Human1.03658849
110RNF2_27304074_Chip-Seq_NSC_Mouse1.02494991
111RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.02005116
112RXR_22108803_ChIP-Seq_LS180_Human1.01852147
113NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01834842
114CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.01246015
115JUN_21703547_ChIP-Seq_K562_Human1.00520910
116RING1B_27294783_Chip-Seq_NPCs_Mouse1.00308732
117YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00019758
118MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99820477
119P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98313667
120* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.97623534
121* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.97623534
122P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97544600
123DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96982111
124TBX20_22328084_ChIP-Seq_HEART_Mouse0.96706778
125TBX20_22080862_ChIP-Seq_HEART_Mouse0.96706778
126PPAR_26484153_Chip-Seq_NCI-H1993_Human0.96617826
127NRF2_20460467_ChIP-Seq_MEFs_Mouse0.96494939
128NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.96494939
129NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.96202445
130SMAD3_21741376_ChIP-Seq_HESCs_Human0.96021815
131FOXO3_23340844_ChIP-Seq_DLD1_Human0.95980203
132TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95166204
133SOX2_27498859_Chip-Seq_STOMACH_Mouse0.93927799
134PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.92785479
135SALL4_18804426_ChIP-ChIP_XEN_Mouse0.92645714
136NANOG_18555785_Chip-Seq_ESCs_Mouse0.92257198
137SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92182120
138NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.91723203
139ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.91452174
140TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90756896
141GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.90660102
142ER_23166858_ChIP-Seq_MCF-7_Human0.89769153
143EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.87903151
144* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.87267948
145SMAD4_21741376_ChIP-Seq_HESCs_Human0.86917770
146KDM2B_26808549_Chip-Seq_SUP-B15_Human0.86184891
147SMAD3_21741376_ChIP-Seq_ESCs_Human0.86031175
148SRY_22984422_ChIP-ChIP_TESTIS_Rat0.85967595
149NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.85863441
150FOXA2_19822575_ChIP-Seq_HepG2_Human0.85517376
151KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.85420634
152TP63_23658742_ChIP-Seq_EP156T_Human0.84258345
153* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.83066422

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.35126145
2MP0003880_abnormal_central_pattern5.49264780
3MP0003635_abnormal_synaptic_transmissio4.26282096
4MP0009745_abnormal_behavioral_response3.63481868
5MP0008438_abnormal_cutaneous_collagen3.62702108
6MP0004270_analgesia3.53262700
7MP0002063_abnormal_learning/memory/cond3.41085670
8MP0002064_seizures3.34015162
9MP0009046_muscle_twitch3.33642564
10MP0001968_abnormal_touch/_nociception3.12398604
11MP0002572_abnormal_emotion/affect_behav2.91495270
12MP0002822_catalepsy2.70170638
13MP0002272_abnormal_nervous_system2.67208510
14MP0001501_abnormal_sleep_pattern2.65529966
15MP0002736_abnormal_nociception_after2.60515888
16MP0003705_abnormal_hypodermis_morpholog2.57281624
17MP0003566_abnormal_cell_adhesion2.56133733
18MP0001486_abnormal_startle_reflex2.48922582
19MP0002734_abnormal_mechanical_nocicepti2.46132658
20MP0001440_abnormal_grooming_behavior2.37680045
21MP0003329_amyloid_beta_deposits2.21581065
22MP0002735_abnormal_chemical_nociception2.15049144
23MP0005423_abnormal_somatic_nervous2.08418882
24MP0002067_abnormal_sensory_capabilities2.03298464
25MP0001958_emphysema2.02368148
26MP0003279_aneurysm2.01072269
27MP0009780_abnormal_chondrocyte_physiolo2.00048653
28MP0002733_abnormal_thermal_nociception2.00040757
29MP0004272_abnormal_basement_membrane1.98405010
30MP0001970_abnormal_pain_threshold1.92872282
31MP0005058_abnormal_lysosome_morphology1.91827402
32MP0005275_abnormal_skin_tensile1.91565969
33MP0008569_lethality_at_weaning1.74847570
34MP0004858_abnormal_nervous_system1.73068721
35MP0004924_abnormal_behavior1.72808256
36MP0005386_behavior/neurological_phenoty1.72808256
37MP0002184_abnormal_innervation1.72166296
38MP0002909_abnormal_adrenal_gland1.71056021
39MP0002557_abnormal_social/conspecific_i1.61176389
40MP0003879_abnormal_hair_cell1.60852504
41MP0003091_abnormal_cell_migration1.59151026
42MP0006276_abnormal_autonomic_nervous1.56003559
43MP0000778_abnormal_nervous_system1.54506453
44MP0004811_abnormal_neuron_physiology1.51249101
45MP0005165_increased_susceptibility_to1.42033611
46MP0002837_dystrophic_cardiac_calcinosis1.41906188
47MP0001529_abnormal_vocalization1.41244026
48MP0001984_abnormal_olfaction1.40386026
49MP0002066_abnormal_motor_capabilities/c1.37295772
50MP0002877_abnormal_melanocyte_morpholog1.36989134
51MP0003191_abnormal_cellular_cholesterol1.36465735
52MP0003633_abnormal_nervous_system1.36349531
53MP0000955_abnormal_spinal_cord1.36092866
54MP0001542_abnormal_bone_strength1.35101807
55MP0005257_abnormal_intraocular_pressure1.32045202
56MP0000013_abnormal_adipose_tissue1.31124981
57MP0001849_ear_inflammation1.30790332
58MP0005646_abnormal_pituitary_gland1.29450091
59MP0002882_abnormal_neuron_morphology1.26498810
60MP0010386_abnormal_urinary_bladder1.26456342
61MP0001905_abnormal_dopamine_level1.23688166
62MP0001188_hyperpigmentation1.23181451
63MP0000604_amyloidosis1.21997270
64MP0002896_abnormal_bone_mineralization1.20214410
65MP0004885_abnormal_endolymph1.17643877
66MP0004142_abnormal_muscle_tone1.17120670
67MP0005023_abnormal_wound_healing1.15874430
68MP0002295_abnormal_pulmonary_circulatio1.15282294
69MP0003453_abnormal_keratinocyte_physiol1.13378718
70MP0008004_abnormal_stomach_pH1.12100226
71MP0003631_nervous_system_phenotype1.11805637
72MP0003787_abnormal_imprinting1.11491990
73MP0004145_abnormal_muscle_electrophysio1.11443922
74MP0006054_spinal_hemorrhage1.10686654
75MP0001502_abnormal_circadian_rhythm1.09696182
76MP0000751_myopathy1.08725600
77MP0010352_gastrointestinal_tract_polyps1.08493931
78MP0005166_decreased_susceptibility_to1.06071616
79MP0003303_peritoneal_inflammation1.04591538
80MP0000579_abnormal_nail_morphology1.04153692
81MP0002796_impaired_skin_barrier1.01603982
82MP0009840_abnormal_foam_cell1.01500208
83MP0008874_decreased_physiological_sensi0.99922488
84MP0004484_altered_response_of0.99066365
85MP0003300_gastrointestinal_ulcer0.98061448
86MP0000343_altered_response_to0.97465450
87MP0003122_maternal_imprinting0.96681741
88MP0009384_cardiac_valve_regurgitation0.94781573
89MP0003075_altered_response_to0.93986788
90MP0002152_abnormal_brain_morphology0.93367182
91MP0004510_myositis0.92885104
92MP0008872_abnormal_physiological_respon0.92653560
93MP0005623_abnormal_meninges_morphology0.92029325
94MP0005503_abnormal_tendon_morphology0.90095432
95MP0005535_abnormal_body_temperature0.89791166
96MP0001299_abnormal_eye_distance/0.89590031
97MP0004215_abnormal_myocardial_fiber0.89358194
98MP0003690_abnormal_glial_cell0.88387390
99MP0001177_atelectasis0.88043509
100MP0002060_abnormal_skin_morphology0.86902112
101MP0002229_neurodegeneration0.86247311
102MP0002069_abnormal_eating/drinking_beha0.85501411
103MP0004742_abnormal_vestibular_system0.83974378
104MP0004085_abnormal_heartbeat0.83713734
105MP0010234_abnormal_vibrissa_follicle0.83519705
106MP0005645_abnormal_hypothalamus_physiol0.83366324
107MP0004084_abnormal_cardiac_muscle0.83173765
108MP0002876_abnormal_thyroid_physiology0.82861884
109MP0000767_abnormal_smooth_muscle0.82663033
110MP0002090_abnormal_vision0.81344965
111MP0006082_CNS_inflammation0.81253516
112MP0002998_abnormal_bone_remodeling0.81001933
113MP0001963_abnormal_hearing_physiology0.80578911
114MP0002972_abnormal_cardiac_muscle0.80137141
115MP0005388_respiratory_system_phenotype0.80026787
116MP0002133_abnormal_respiratory_system0.80026787
117MP0003634_abnormal_glial_cell0.79461171
118MP0003941_abnormal_skin_development0.78312975
119MP0001348_abnormal_lacrimal_gland0.77717459
120MP0005551_abnormal_eye_electrophysiolog0.77196285
121MP0003632_abnormal_nervous_system0.77111880
122MP0005464_abnormal_platelet_physiology0.77030351
123MP0000920_abnormal_myelination0.76531441
124MP0003950_abnormal_plasma_membrane0.75991413
125MP0005499_abnormal_olfactory_system0.75470483
126MP0005394_taste/olfaction_phenotype0.75470483
127MP0008260_abnormal_autophagy0.75156925
128MP0003183_abnormal_peptide_metabolism0.72678886
129MP0003448_altered_tumor_morphology0.70555064
130MP0005164_abnormal_response_to0.70337117
131MP0004036_abnormal_muscle_relaxation0.68279084
132MP0010368_abnormal_lymphatic_system0.67727790
133MP0001664_abnormal_digestion0.63150990
134MP0008961_abnormal_basal_metabolism0.62374506
135MP0002752_abnormal_somatic_nervous0.60806808
136MP0005167_abnormal_blood-brain_barrier0.60503830
137MP0003172_abnormal_lysosome_physiology0.56243066
138MP0005620_abnormal_muscle_contractility0.55043296
139MP0001943_abnormal_respiration0.54248275
140MP0005171_absent_coat_pigmentation0.53772542
141MP0001485_abnormal_pinna_reflex0.53656773
142MP0005409_darkened_coat_color0.52876321
143MP0004233_abnormal_muscle_weight0.52738034
144MP0003137_abnormal_impulse_conducting0.52112989
145MP0000569_abnormal_digit_pigmentation0.50936737
146MP0005595_abnormal_vascular_smooth0.50840534
147MP0000631_abnormal_neuroendocrine_gland0.49567480
148MP0001765_abnormal_ion_homeostasis0.49539738
149MP0003045_fibrosis0.49407963
150MP0004043_abnormal_pH_regulation0.48906582

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.57567714
2Focal seizures (HP:0007359)6.17249977
3Myokymia (HP:0002411)5.76913501
4Atonic seizures (HP:0010819)5.71711387
5Visual hallucinations (HP:0002367)5.37814940
6Epileptic encephalopathy (HP:0200134)5.32445654
7Absence seizures (HP:0002121)4.88741587
8Febrile seizures (HP:0002373)4.86762139
9Dialeptic seizures (HP:0011146)4.52615896
10Generalized tonic-clonic seizures (HP:0002069)4.26633377
11Hyperventilation (HP:0002883)4.21205278
12Premature rupture of membranes (HP:0001788)4.11073328
13Progressive cerebellar ataxia (HP:0002073)3.96906128
14Broad-based gait (HP:0002136)3.69181698
15Supranuclear gaze palsy (HP:0000605)3.61601174
16Cerebral inclusion bodies (HP:0100314)3.50503973
17Action tremor (HP:0002345)3.49786031
18Amblyopia (HP:0000646)3.46154168
19Poor eye contact (HP:0000817)3.41838790
20Neurofibrillary tangles (HP:0002185)3.31616903
21Gaze-evoked nystagmus (HP:0000640)3.26961519
22Dysdiadochokinesis (HP:0002075)3.24074247
23Protrusio acetabuli (HP:0003179)3.12724310
24Truncal ataxia (HP:0002078)3.12097424
25Abnormality of binocular vision (HP:0011514)3.07874546
26Diplopia (HP:0000651)3.07874546
27Impaired social interactions (HP:0000735)3.06886964
28Abnormal social behavior (HP:0012433)3.06886964
29Dysmetria (HP:0001310)3.04344096
30Depression (HP:0000716)3.02488669
31Anxiety (HP:0000739)2.94349787
32Hemiparesis (HP:0001269)2.91396849
33Impaired vibration sensation in the lower limbs (HP:0002166)2.90610926
34Excessive salivation (HP:0003781)2.88621948
35Drooling (HP:0002307)2.88621948
36Abnormal eating behavior (HP:0100738)2.83842940
37Mutism (HP:0002300)2.82111405
38Atrophic scars (HP:0001075)2.81176285
39Arterial tortuosity (HP:0005116)2.79333490
40Vascular tortuosity (HP:0004948)2.78787152
41Absent speech (HP:0001344)2.71445461
42Abnormality of liposaccharide metabolism (HP:0010968)2.70445635
43Abnormality of glycosphingolipid metabolism (HP:0004343)2.70445635
44Abnormality of glycolipid metabolism (HP:0010969)2.70445635
45Scanning speech (HP:0002168)2.66109932
46Status epilepticus (HP:0002133)2.65765212
47Dysostosis multiplex (HP:0000943)2.63143104
48Impaired smooth pursuit (HP:0007772)2.60578663
49Papilledema (HP:0001085)2.58243496
50Mitral stenosis (HP:0001718)2.57155693
51Urinary bladder sphincter dysfunction (HP:0002839)2.56493720
52Obstructive sleep apnea (HP:0002870)2.54351543
53Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.53005320
54Stereotypic behavior (HP:0000733)2.51356185
55Progressive inability to walk (HP:0002505)2.51224928
56Urinary glycosaminoglycan excretion (HP:0003541)2.48098951
57Mucopolysacchariduria (HP:0008155)2.48098951
58Epileptiform EEG discharges (HP:0011182)2.46481631
59Aortic dissection (HP:0002647)2.44952294
60Abnormality of the lower motor neuron (HP:0002366)2.44089622
61Inability to walk (HP:0002540)2.43400610
62Postural instability (HP:0002172)2.42829801
63Tetraparesis (HP:0002273)2.42699386
64Termporal pattern (HP:0011008)2.41576740
65Insidious onset (HP:0003587)2.41576740
66Neuronal loss in central nervous system (HP:0002529)2.40410093
67Distal upper limb amyotrophy (HP:0007149)2.39436505
68Upper limb amyotrophy (HP:0009129)2.39436505
69Generalized myoclonic seizures (HP:0002123)2.37845611
70Ankle clonus (HP:0011448)2.37145010
71Abnormality of polysaccharide metabolism (HP:0011012)2.34002428
72Abnormality of glycosaminoglycan metabolism (HP:0004371)2.34002428
73Abnormality of mucopolysaccharide metabolism (HP:0011020)2.34002428
74Nuclear cataract (HP:0100018)2.31990633
75Fragile skin (HP:0001030)2.31335941
76Vertebral compression fractures (HP:0002953)2.28552907
77Genetic anticipation (HP:0003743)2.28253456
78Fetal akinesia sequence (HP:0001989)2.27670064
79Cerebral aneurysm (HP:0004944)2.27244752
80Hemiplegia (HP:0002301)2.26556388
81Bradykinesia (HP:0002067)2.24353783
82Dysmetric saccades (HP:0000641)2.24074960
83EEG with generalized epileptiform discharges (HP:0011198)2.23821878
84Abnormality of ocular smooth pursuit (HP:0000617)2.22291824
85Urinary urgency (HP:0000012)2.21797682
86Inappropriate behavior (HP:0000719)2.21091544
87Protruding tongue (HP:0010808)2.19534268
88Bundle branch block (HP:0011710)2.17900000
89Osteolytic defects of the hand bones (HP:0009699)2.17361068
90Osteolytic defects of the phalanges of the hand (HP:0009771)2.17361068
91Intention tremor (HP:0002080)2.16690406
92Hand muscle atrophy (HP:0009130)2.16241268
93Resting tremor (HP:0002322)2.16122886
94Tetraplegia (HP:0002445)2.14932364
95Cardiovascular calcification (HP:0011915)2.13783055
96Torticollis (HP:0000473)2.13621801
97Aortic aneurysm (HP:0004942)2.11193485
98Wormian bones (HP:0002645)2.09167347
99Axonal loss (HP:0003447)2.08683096
100Pheochromocytoma (HP:0002666)2.06679468
101Lower limb amyotrophy (HP:0007210)2.05267206
102Rapidly progressive (HP:0003678)2.05166329
103Abnormality of salivation (HP:0100755)2.04818961
104Hypsarrhythmia (HP:0002521)2.02742656
105Polyphagia (HP:0002591)2.01493869
106Abnormality of the corticospinal tract (HP:0002492)2.01476321
107Spastic gait (HP:0002064)2.01402806
108Gait ataxia (HP:0002066)1.99839677
109Hyperparathyroidism (HP:0000843)1.99518355
110Apathy (HP:0000741)1.99485135
111Abnormality of dentin (HP:0010299)1.99416393
112Rigidity (HP:0002063)1.97592630
113Amyotrophic lateral sclerosis (HP:0007354)1.97118031
114Delusions (HP:0000746)1.96776888
115Psychosis (HP:0000709)1.96651455
116Impaired vibratory sensation (HP:0002495)1.96486916
117Focal dystonia (HP:0004373)1.95835399
118Dilatation of the ascending aorta (HP:0005111)1.95351964
119Limb dystonia (HP:0002451)1.94329896
120Lower limb asymmetry (HP:0100559)1.92064485
121Abnormal atrioventricular conduction (HP:0005150)1.91953431
122Cervical subluxation (HP:0003308)1.91523456
123Lower limb muscle weakness (HP:0007340)1.91336671
124Clumsiness (HP:0002312)1.91330202
125Postural tremor (HP:0002174)1.89905457
126Blue irides (HP:0000635)1.89670111
127Vascular calcification (HP:0004934)1.88277498
128Annular pancreas (HP:0001734)1.87720479
129Neuroendocrine neoplasm (HP:0100634)1.85810850
130Atrioventricular block (HP:0001678)1.84755789
131Incomplete penetrance (HP:0003829)1.84057480
132Ankle contracture (HP:0006466)1.82424275
133Follicular hyperkeratosis (HP:0007502)1.80888709
134Hypoventilation (HP:0002791)1.77582380
135Heart block (HP:0012722)1.76683513
136Loss of speech (HP:0002371)1.76414517
137Right ventricular cardiomyopathy (HP:0011663)1.75340301
138Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.74223297
139Thickened helices (HP:0000391)1.73788533
140Akinesia (HP:0002304)1.72862001
141Exotropia (HP:0000577)1.72745988
142Megalencephaly (HP:0001355)1.72553954
143Craniofacial dystonia (HP:0012179)1.72363957
144Aplasia involving bones of the extremities (HP:0009825)1.71807449
145Aplasia involving bones of the upper limbs (HP:0009823)1.71807449
146Aplasia of the phalanges of the hand (HP:0009802)1.71807449
147Diminished motivation (HP:0000745)1.71501889
148Hyperextensible skin (HP:0000974)1.70419572
149Distal lower limb amyotrophy (HP:0008944)1.70151130
150Horizontal nystagmus (HP:0000666)1.70035189
151Ventricular fibrillation (HP:0001663)1.69894857
152Retinal dysplasia (HP:0007973)1.69252816
153Distal lower limb muscle weakness (HP:0009053)1.68269442
154Bladder diverticulum (HP:0000015)1.67647054
155Dementia (HP:0000726)1.66566347
156Shallow orbits (HP:0000586)1.65935963
157Ankyloglossia (HP:0010296)1.65428498
158Genu recurvatum (HP:0002816)1.64998826

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.10873350
2NTRK34.49759087
3RIPK43.85419836
4MAP3K93.63828955
5MAP3K42.79232623
6MYLK2.52513034
7RIPK12.52434679
8MINK12.49013255
9MAP2K72.48805632
10MAP3K122.45085264
11DAPK22.42768392
12KSR22.26657702
13CASK2.25838747
14TESK12.20542157
15PLK22.08981076
16MAP2K42.06808868
17NTRK12.02047850
18PAK61.97973182
19ARAF1.87671962
20GRK51.86587558
21MARK11.81976135
22LIMK11.79523584
23BMPR21.68049334
24PDGFRA1.66234238
25KSR11.62929163
26MAP3K131.62397296
27CAMKK11.60551774
28DAPK11.60404631
29NTRK21.53433458
30PNCK1.53180554
31SIK21.46858344
32CDK51.44184534
33PTK21.42217347
34CAMKK21.36867809
35PTK2B1.30103212
36CDK191.28029885
37IRAK31.25854599
38FES1.24408925
39PRKCG1.23150298
40STK241.20852955
41LMTK21.19932129
42MAP3K21.16364850
43STK381.13660148
44PAK41.12569568
45CAMK2A1.11544997
46PRKD31.11305871
47PRPF4B1.06224596
48RAF11.05877353
49TNIK0.99053949
50PRKG20.97965513
51CAMK2B0.97654839
52TTN0.97125822
53TRIB30.92493416
54MAP3K30.88972493
55TYRO30.87877675
56FGR0.87719520
57EPHA20.86155750
58OXSR10.85091272
59CDK180.82955004
60CDK150.81364494
61CDK140.81031947
62NME10.80583665
63MAPK130.76874052
64MST1R0.75212860
65GRK70.75020942
66LATS20.74488311
67PAK30.73839230
68CDC42BPA0.71973731
69MOS0.70534767
70TAOK20.70222503
71PAK20.69813414
72CAMK10.69411273
73CDK11A0.69191301
74SGK10.68978082
75CCNB10.68900883
76RET0.68832403
77TRPM70.68242297
78MET0.67414727
79PRKCE0.67391691
80UHMK10.67074521
81STK110.66430418
82MAP3K10.65603461
83WNK10.65489069
84FER0.63436418
85PKN20.62647184
86CAMK2D0.61823319
87DYRK1A0.61543268
88PRKCH0.60513231
89MAP2K10.60234795
90TGFBR20.60189214
91PDPK10.59395052
92PDGFRB0.58897797
93ROCK10.58854699
94BMX0.58686396
95SGK4940.58479737
96SGK2230.58479737
97JAK10.58452672
98NEK90.57012992
99PDK10.55990495
100TNK20.55373949
101NEK60.54675132
102SIK10.53208564
103CAMK2G0.52473987
104SGK20.50784218
105PINK10.50689399
106GRK60.49756081
107MAPK70.49531194
108ROCK20.49084291
109MAP3K110.48605739
110RPS6KA20.48538932
111MAPKAPK30.47894389
112FYN0.45794540
113TAOK10.45513918
114DAPK30.44132591
115PHKG10.43099908
116PHKG20.43099908
117MAPK120.42864926
118CSNK1G20.40185466
119MUSK0.40031290
120MAPK100.40029995
121MARK20.39281600
122RPS6KA30.38628978
123ADRBK10.38301038
124BRAF0.38269118
125SCYL20.37740539
126PRKCZ0.37306639
127AKT30.36073444
128SGK30.36005383
129CAMK1G0.35924726
130DMPK0.33700527
131MAP3K60.32389649
132PRKACA0.31449914
133DDR20.30680352
134PRKCA0.30288036

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.82968316
2Synaptic vesicle cycle_Homo sapiens_hsa047213.06848821
3Long-term potentiation_Homo sapiens_hsa047202.83679347
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.75250757
5GABAergic synapse_Homo sapiens_hsa047272.57808705
6Circadian entrainment_Homo sapiens_hsa047132.55917361
7Glutamatergic synapse_Homo sapiens_hsa047242.51085718
8Amphetamine addiction_Homo sapiens_hsa050312.45645991
9Morphine addiction_Homo sapiens_hsa050322.41935600
10Olfactory transduction_Homo sapiens_hsa047402.38734024
11Salivary secretion_Homo sapiens_hsa049702.23335220
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.11280151
13Dopaminergic synapse_Homo sapiens_hsa047282.09030122
14Collecting duct acid secretion_Homo sapiens_hsa049661.99513443
15Taste transduction_Homo sapiens_hsa047421.90821943
16Renin secretion_Homo sapiens_hsa049241.87760183
17Gastric acid secretion_Homo sapiens_hsa049711.87069632
18Long-term depression_Homo sapiens_hsa047301.86384368
19Insulin secretion_Homo sapiens_hsa049111.74417426
20Serotonergic synapse_Homo sapiens_hsa047261.72820798
21Cholinergic synapse_Homo sapiens_hsa047251.70957679
22Oxytocin signaling pathway_Homo sapiens_hsa049211.69495510
23Calcium signaling pathway_Homo sapiens_hsa040201.66138335
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.63042026
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.55242028
26Cocaine addiction_Homo sapiens_hsa050301.47837753
27GnRH signaling pathway_Homo sapiens_hsa049121.43153770
28Glycosaminoglycan degradation_Homo sapiens_hsa005311.29195014
29Gap junction_Homo sapiens_hsa045401.28746871
30ECM-receptor interaction_Homo sapiens_hsa045121.28015451
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.27526983
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.27156656
33Vibrio cholerae infection_Homo sapiens_hsa051101.26621308
34cAMP signaling pathway_Homo sapiens_hsa040241.24573020
35Amoebiasis_Homo sapiens_hsa051461.22744604
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.20903434
37Lysosome_Homo sapiens_hsa041421.20822566
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.18777722
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.14995705
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.12223994
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.12093442
42Estrogen signaling pathway_Homo sapiens_hsa049151.11161959
43Cardiac muscle contraction_Homo sapiens_hsa042601.09913653
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.09346125
45Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.07802611
46Focal adhesion_Homo sapiens_hsa045101.06798892
47cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06497507
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.05673022
49Glioma_Homo sapiens_hsa052141.04551059
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.00921244
51Axon guidance_Homo sapiens_hsa043600.98890565
52Vascular smooth muscle contraction_Homo sapiens_hsa042700.97943680
53Other glycan degradation_Homo sapiens_hsa005110.95659783
54Melanogenesis_Homo sapiens_hsa049160.95622415
55Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.91047944
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90485253
57Type II diabetes mellitus_Homo sapiens_hsa049300.89526650
58Pancreatic secretion_Homo sapiens_hsa049720.88696106
59Sphingolipid metabolism_Homo sapiens_hsa006000.87116442
60ErbB signaling pathway_Homo sapiens_hsa040120.86330494
61Proteoglycans in cancer_Homo sapiens_hsa052050.85753466
62Vitamin B6 metabolism_Homo sapiens_hsa007500.83054737
63Dilated cardiomyopathy_Homo sapiens_hsa054140.80809502
64Thyroid hormone synthesis_Homo sapiens_hsa049180.80443167
65Alzheimers disease_Homo sapiens_hsa050100.80275818
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79725166
67Phototransduction_Homo sapiens_hsa047440.77836407
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.77571361
69Dorso-ventral axis formation_Homo sapiens_hsa043200.75954461
70Protein digestion and absorption_Homo sapiens_hsa049740.75918176
71Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.75422050
72Salmonella infection_Homo sapiens_hsa051320.75238789
73Leukocyte transendothelial migration_Homo sapiens_hsa046700.74374601
74Oocyte meiosis_Homo sapiens_hsa041140.72205856
75VEGF signaling pathway_Homo sapiens_hsa043700.71535922
76Choline metabolism in cancer_Homo sapiens_hsa052310.70879668
77Oxidative phosphorylation_Homo sapiens_hsa001900.69735337
78Tight junction_Homo sapiens_hsa045300.67884673
79MAPK signaling pathway_Homo sapiens_hsa040100.67486526
80Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.67096024
81Adherens junction_Homo sapiens_hsa045200.66734279
82African trypanosomiasis_Homo sapiens_hsa051430.66437788
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64706736
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63983742
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62865702
86Rheumatoid arthritis_Homo sapiens_hsa053230.60036526
87Rap1 signaling pathway_Homo sapiens_hsa040150.58000982
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.55513005
89Type I diabetes mellitus_Homo sapiens_hsa049400.54780086
90Ras signaling pathway_Homo sapiens_hsa040140.54190270
91Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53029572
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51439106
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51312874
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.50915713
95Inositol phosphate metabolism_Homo sapiens_hsa005620.50657226
96Glucagon signaling pathway_Homo sapiens_hsa049220.49752698
97Pertussis_Homo sapiens_hsa051330.48324064
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47139530
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.46194675
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45665450
101Sulfur metabolism_Homo sapiens_hsa009200.45484999
102Insulin signaling pathway_Homo sapiens_hsa049100.45430838
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44992141
104Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.42866419
105Prion diseases_Homo sapiens_hsa050200.42153483
106Phagosome_Homo sapiens_hsa041450.40927317
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39459107
108mTOR signaling pathway_Homo sapiens_hsa041500.37879642
109Parkinsons disease_Homo sapiens_hsa050120.37756124
110Endocytosis_Homo sapiens_hsa041440.37295159
111Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.34939379
112Chemokine signaling pathway_Homo sapiens_hsa040620.34365971
113Renal cell carcinoma_Homo sapiens_hsa052110.33965352
114Mineral absorption_Homo sapiens_hsa049780.33714859
115Non-small cell lung cancer_Homo sapiens_hsa052230.33271276
116Alcoholism_Homo sapiens_hsa050340.33105560
117Wnt signaling pathway_Homo sapiens_hsa043100.32040885
118Regulation of actin cytoskeleton_Homo sapiens_hsa048100.31577683
119Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.31024937
120Bile secretion_Homo sapiens_hsa049760.30881938
121Platelet activation_Homo sapiens_hsa046110.28350337
122Ovarian steroidogenesis_Homo sapiens_hsa049130.27870479
123Circadian rhythm_Homo sapiens_hsa047100.27812480
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.27326152
125Tuberculosis_Homo sapiens_hsa051520.27281207

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