NPS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome reaction (GO:0007340)8.14890719
2cell wall macromolecule catabolic process (GO:0016998)8.08040817
3cell wall macromolecule metabolic process (GO:0044036)8.08040817
4fusion of sperm to egg plasma membrane (GO:0007342)7.26551888
5sperm motility (GO:0030317)7.23270549
6motile cilium assembly (GO:0044458)6.56923182
7piRNA metabolic process (GO:0034587)6.56287467
8positive regulation of cellular amide metabolic process (GO:0034250)6.38908355
9sperm-egg recognition (GO:0035036)6.12262866
10acrosome assembly (GO:0001675)6.04718584
11epithelial cilium movement (GO:0003351)6.00288799
12axonemal dynein complex assembly (GO:0070286)5.86872104
13multicellular organism reproduction (GO:0032504)5.72170860
14plasma membrane fusion (GO:0045026)5.71820164
15binding of sperm to zona pellucida (GO:0007339)5.54165343
16cilium or flagellum-dependent cell motility (GO:0001539)5.50830854
17cell-cell recognition (GO:0009988)5.39321250
18regulation of inclusion body assembly (GO:0090083)5.37490124
19reproduction (GO:0000003)5.36414154
20L-serine metabolic process (GO:0006563)5.12105311
21male meiosis (GO:0007140)5.04581301
22spermatid development (GO:0007286)4.98546998
23organic cation transport (GO:0015695)4.79536312
24regulation of sequestering of triglyceride (GO:0010889)4.57859261
25cilium movement (GO:0003341)4.49675544
26synaptonemal complex organization (GO:0070193)4.44477738
27sperm capacitation (GO:0048240)4.42441223
28single strand break repair (GO:0000012)4.32057421
29epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.27460532
30DNA deamination (GO:0045006)4.26815849
31male meiosis I (GO:0007141)4.16833747
32negative regulation of protein oligomerization (GO:0032460)4.16660685
33spermatid nucleus differentiation (GO:0007289)4.12333690
34sexual reproduction (GO:0019953)4.11265682
35synaptonemal complex assembly (GO:0007130)3.98792466
36calcium ion-dependent exocytosis (GO:0017156)3.96474690
37DNA methylation involved in gamete generation (GO:0043046)3.73911633
38response to misfolded protein (GO:0051788)3.72402725
39single fertilization (GO:0007338)3.72282561
40phosphatidylglycerol biosynthetic process (GO:0006655)3.71172234
41regulation of cilium movement (GO:0003352)3.66096836
42negative regulation of platelet activation (GO:0010544)3.52946473
43tricarboxylic acid cycle (GO:0006099)3.50299374
44glial cell proliferation (GO:0014009)3.50088025
45chromosome organization involved in meiosis (GO:0070192)3.48532242
46regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.40863026
47cardiolipin metabolic process (GO:0032048)3.40773882
48meiotic cell cycle (GO:0051321)3.39480871
49positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.35216738
50microtubule severing (GO:0051013)3.34623369
51meiotic nuclear division (GO:0007126)3.34557304
52negative regulation of homotypic cell-cell adhesion (GO:0034111)3.34369020
53chaperone-mediated protein complex assembly (GO:0051131)3.34042989
54meiosis I (GO:0007127)3.23476146
55protein localization to cilium (GO:0061512)3.23015308
56mitochondrial calcium ion transport (GO:0006851)3.22118208
57microtubule depolymerization (GO:0007019)3.21070716
58negative regulation of execution phase of apoptosis (GO:1900118)3.20134469
59spermatogenesis (GO:0007283)3.17812296
60male gamete generation (GO:0048232)3.16418590
61ventricular system development (GO:0021591)3.13628413
62intraciliary transport (GO:0042073)3.06746690
63serine family amino acid biosynthetic process (GO:0009070)3.06077836
64regulation of beta-amyloid formation (GO:1902003)3.05812611
65regulation of acyl-CoA biosynthetic process (GO:0050812)3.04216957
66fertilization (GO:0009566)3.00182357
67negative regulation of inclusion body assembly (GO:0090084)2.99577862
68regulation of cofactor metabolic process (GO:0051193)2.98642960
69regulation of coenzyme metabolic process (GO:0051196)2.98642960
70regulation of glycogen (starch) synthase activity (GO:2000465)2.96884350
71synapsis (GO:0007129)2.96235550
72deoxyribose phosphate biosynthetic process (GO:0046385)2.90931977
732-deoxyribonucleotide biosynthetic process (GO:0009265)2.90931977
74regulation of amyloid precursor protein catabolic process (GO:1902991)2.89711577
75negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.88407541
76microtubule polymerization or depolymerization (GO:0031109)2.87976888
77oxidative phosphorylation (GO:0006119)2.86084716
78gamete generation (GO:0007276)2.84397945
79NADH metabolic process (GO:0006734)2.81567590
80positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.78917570
81mitochondrial calcium ion homeostasis (GO:0051560)2.78339699
82respiratory system process (GO:0003016)2.77078399
83regulation of tight junction assembly (GO:2000810)2.75782938
84glycolytic process (GO:0006096)2.75256313
85positive regulation of vasculogenesis (GO:2001214)2.73770508
86valine metabolic process (GO:0006573)2.68851370
87negative regulation of T-helper cell differentiation (GO:0045623)2.67289435
88negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.67289435
89peroxisome fission (GO:0016559)2.66332248
90lipid particle organization (GO:0034389)2.65865676
91regulation of cellular amide metabolic process (GO:0034248)2.61980918
92protein refolding (GO:0042026)2.61892227
93regulation of response to osmotic stress (GO:0047484)2.60840467
94regulation of phospholipid biosynthetic process (GO:0071071)2.59515656
95adenine nucleotide transport (GO:0051503)2.59438195
96urinary tract smooth muscle contraction (GO:0014848)2.57757716
97cellular process involved in reproduction in multicellular organism (GO:0022412)2.57753843
98protein K11-linked deubiquitination (GO:0035871)2.56709646
99dermatan sulfate biosynthetic process (GO:0030208)2.56452372
100germ cell development (GO:0007281)2.55146449

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse6.79859341
2RBPJ_22232070_ChIP-Seq_NCS_Mouse5.75453339
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.58752091
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.21620581
5FLI1_27457419_Chip-Seq_LIVER_Mouse2.44247862
6PCGF2_27294783_Chip-Seq_ESCs_Mouse2.33813456
7ZNF274_21170338_ChIP-Seq_K562_Hela2.16561554
8ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.06569195
9EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.05656243
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.01885547
11PCGF2_27294783_Chip-Seq_NPCs_Mouse1.99648983
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.90648715
13EZH2_22144423_ChIP-Seq_EOC_Human1.86283631
14CBX2_27304074_Chip-Seq_ESCs_Mouse1.75051991
15REST_21632747_ChIP-Seq_MESCs_Mouse1.66721216
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.65057180
17PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.60733378
18STAT6_21828071_ChIP-Seq_BEAS2B_Human1.58112148
19KDM2B_26808549_Chip-Seq_REH_Human1.56208314
20NFE2_27457419_Chip-Seq_LIVER_Mouse1.55910525
21TAL1_26923725_Chip-Seq_HPCs_Mouse1.53444538
22ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.51437616
23VDR_22108803_ChIP-Seq_LS180_Human1.51269621
24SUZ12_27294783_Chip-Seq_NPCs_Mouse1.49185676
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.43664279
26CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.41448287
27EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.41356982
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.39872532
29EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.36763389
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.35394678
31STAT3_18555785_Chip-Seq_ESCs_Mouse1.33419116
32FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.33068172
33LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.31507989
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27657291
35TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26352132
36CTCF_18555785_ChIP-Seq_MESCs_Mouse1.22508568
37MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.22274665
38SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.22240607
39RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.19659669
40SUZ12_18555785_Chip-Seq_ESCs_Mouse1.19091883
41TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18527141
42STAT1_17558387_ChIP-Seq_HELA_Human1.17891187
43RAD21_21589869_ChIP-Seq_MESCs_Mouse1.17778507
44SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.16095640
45E2F1_18555785_Chip-Seq_ESCs_Mouse1.13569668
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12681897
47* GF1B_26923725_Chip-Seq_HPCs_Mouse1.11455316
48* GATA3_21867929_ChIP-Seq_CD8_Mouse1.11023905
49CMYC_18555785_Chip-Seq_ESCs_Mouse1.09361088
50KAP1_22055183_ChIP-Seq_ESCs_Mouse1.08170396
51P53_21459846_ChIP-Seq_SAOS-2_Human1.08076414
52P53_22387025_ChIP-Seq_ESCs_Mouse1.07606817
53LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.07468828
54* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07040280
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.06433669
56EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.04843864
57ELK4_26923725_Chip-Seq_MESODERM_Mouse1.04809243
58* SOX2_22085726_ChIP-Seq_NPCs_Mouse1.04344437
59PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.04060036
60OCT4_18555785_Chip-Seq_ESCs_Mouse1.04045552
61FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.03832911
62NANOG_18555785_Chip-Seq_ESCs_Mouse1.02524378
63GBX2_23144817_ChIP-Seq_PC3_Human1.01864420
64* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01546091
65SMAD4_21799915_ChIP-Seq_A2780_Human1.01088669
66P300_18555785_Chip-Seq_ESCs_Mouse1.00150937
67* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99303234
68HTT_18923047_ChIP-ChIP_STHdh_Human0.98963806
69MYC_27129775_Chip-Seq_CORNEA_Mouse0.97482479
70PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95100743
71NMYC_18555785_Chip-Seq_ESCs_Mouse0.94727256
72SOX2_18555785_Chip-Seq_ESCs_Mouse0.94520264
73EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.94412842
74CBP_20019798_ChIP-Seq_JUKART_Human0.94245251
75IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94245251
76NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.93956425
77ER_23166858_ChIP-Seq_MCF-7_Human0.93906366
78HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.92617652
79PU1_27457419_Chip-Seq_LIVER_Mouse0.91127112
80CTCF_18555785_Chip-Seq_ESCs_Mouse0.89720229
81KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.89095034
82* GF1_26923725_Chip-Seq_HPCs_Mouse0.88554453
83* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88454936
84* POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.88454936
85REST_18959480_ChIP-ChIP_MESCs_Mouse0.88049779
86CTCF_20526341_ChIP-Seq_ESCs_Human0.87956184
87KLF4_18555785_Chip-Seq_ESCs_Mouse0.87792756
88SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.87183012
89BCAT_22108803_ChIP-Seq_LS180_Human0.87105609
90LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.87096437
91KLF5_20875108_ChIP-Seq_MESCs_Mouse0.86833049
92RARA_24833708_ChIP-Seq_LIVER_Mouse0.85449289
93RNF2_27304074_Chip-Seq_NSC_Mouse0.84658314
94SMAD3_21741376_ChIP-Seq_ESCs_Human0.84628576
95RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.83556049
96RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.83360047
97FLI1_21867929_ChIP-Seq_CD8_Mouse0.82607144
98P300_19829295_ChIP-Seq_ESCs_Human0.82464290
99WDR5_24793694_ChIP-Seq_LNCAP_Human0.81724402
100SMAD1_18555785_Chip-Seq_ESCs_Mouse0.80851368

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization8.07897888
2MP0002736_abnormal_nociception_after4.17113248
3MP0003646_muscle_fatigue3.61733791
4MP0001968_abnormal_touch/_nociception3.58251275
5MP0003698_abnormal_male_reproductive3.30367406
6MP0009697_abnormal_copulation3.00514561
7MP0001929_abnormal_gametogenesis2.89022152
8MP0003329_amyloid_beta_deposits2.73930586
9MP0003279_aneurysm2.41854955
10MP0000566_synostosis2.41448175
11MP0002638_abnormal_pupillary_reflex2.37344164
12MP0008877_abnormal_DNA_methylation2.31148934
13MP0004782_abnormal_surfactant_physiolog2.30042896
14MP0002735_abnormal_chemical_nociception2.23001049
15MP0006035_abnormal_mitochondrial_morpho2.22354963
16MP0001986_abnormal_taste_sensitivity2.10755925
17MP0006036_abnormal_mitochondrial_physio2.08597163
18MP0005409_darkened_coat_color2.04081066
19MP0005167_abnormal_blood-brain_barrier1.98590462
20MP0004043_abnormal_pH_regulation1.97151427
21MP0002733_abnormal_thermal_nociception1.91121986
22MP0002210_abnormal_sex_determination1.87666184
23MP0004858_abnormal_nervous_system1.81707956
24MP0005379_endocrine/exocrine_gland_phen1.81056170
25MP0005670_abnormal_white_adipose1.79285361
26MP0005646_abnormal_pituitary_gland1.78669147
27MP0002734_abnormal_mechanical_nocicepti1.72856182
28MP0003195_calcinosis1.72794265
29MP0001177_atelectasis1.71095955
30MP0002161_abnormal_fertility/fecundity1.67622292
31MP0004130_abnormal_muscle_cell1.64703187
32MP0001145_abnormal_male_reproductive1.61909132
33MP0004859_abnormal_synaptic_plasticity1.52842599
34MP0004142_abnormal_muscle_tone1.47681496
35MP0004270_analgesia1.45362052
36MP0005535_abnormal_body_temperature1.45128027
37MP0005083_abnormal_biliary_tract1.40538497
38MP0003186_abnormal_redox_activity1.40325522
39MP0000604_amyloidosis1.39379780
40MP0000653_abnormal_sex_gland1.37715212
41MP0009840_abnormal_foam_cell1.37606996
42MP0002971_abnormal_brown_adipose1.36090379
43MP0003806_abnormal_nucleotide_metabolis1.33651712
44MP0002163_abnormal_gland_morphology1.24533554
45MP0004036_abnormal_muscle_relaxation1.20901124
46MP0003122_maternal_imprinting1.17987766
47MP0010094_abnormal_chromosome_stability1.16803512
48MP0001970_abnormal_pain_threshold1.15428068
49MP0005332_abnormal_amino_acid1.14556649
50MP0000372_irregular_coat_pigmentation1.14026076
51MP0001727_abnormal_embryo_implantation1.12211887
52MP0000647_abnormal_sebaceous_gland1.12118610
53MP0000537_abnormal_urethra_morphology1.10701146
54MP0000751_myopathy1.05494421
55MP0000358_abnormal_cell_content/1.04040294
56MP0009046_muscle_twitch1.02171957
57MP0010329_abnormal_lipoprotein_level0.96648665
58MP0001984_abnormal_olfaction0.96209949
59MP0001958_emphysema0.95515495
60MP0002160_abnormal_reproductive_system0.94981161
61MP0003690_abnormal_glial_cell0.91963967
62MP0008058_abnormal_DNA_repair0.90141389
63MP0003880_abnormal_central_pattern0.90130991
64MP0005595_abnormal_vascular_smooth0.89388193
65MP0002133_abnormal_respiratory_system0.88773567
66MP0005388_respiratory_system_phenotype0.88773567
67MP0002254_reproductive_system_inflammat0.88009186
68MP0005365_abnormal_bile_salt0.87128183
69MP0001529_abnormal_vocalization0.85961612
70MP0004808_abnormal_hematopoietic_stem0.85517895
71MP0002132_abnormal_respiratory_system0.85507412
72MP0002184_abnormal_innervation0.84383465
73MP0003632_abnormal_nervous_system0.82474722
74MP0003635_abnormal_synaptic_transmissio0.81714354
75MP0002102_abnormal_ear_morphology0.81199635
76MP0002118_abnormal_lipid_homeostasis0.80311840
77MP0002972_abnormal_cardiac_muscle0.73777465
78MP0002282_abnormal_trachea_morphology0.72151312
79MP0002396_abnormal_hematopoietic_system0.70212742
80MP0002272_abnormal_nervous_system0.68847771
81MP0001915_intracranial_hemorrhage0.68829599
82MP0006054_spinal_hemorrhage0.65092104
83MP0001299_abnormal_eye_distance/0.64563349
84MP0005584_abnormal_enzyme/coenzyme_acti0.64171359
85MP0004084_abnormal_cardiac_muscle0.64164322
86MP0008569_lethality_at_weaning0.62555120
87MP0002067_abnormal_sensory_capabilities0.61894126
88MP0003787_abnormal_imprinting0.58701638
89MP0005620_abnormal_muscle_contractility0.57880956
90MP0004233_abnormal_muscle_weight0.57868868
91MP0001905_abnormal_dopamine_level0.57793244
92MP0005666_abnormal_adipose_tissue0.57780389
93MP0001486_abnormal_startle_reflex0.56836809
94MP0006292_abnormal_olfactory_placode0.56327726
95MP0000383_abnormal_hair_follicle0.52224444
96MP0000538_abnormal_urinary_bladder0.52177456
97MP0004811_abnormal_neuron_physiology0.50173802
98MP0003121_genomic_imprinting0.49517475
99MP0006276_abnormal_autonomic_nervous0.49070971
100MP0002064_seizures0.48794215

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)7.88370374
2Absent/shortened dynein arms (HP:0200106)7.88370374
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.47036284
4Abnormal respiratory epithelium morphology (HP:0012253)6.09123228
5Abnormal respiratory motile cilium morphology (HP:0005938)6.09123228
6Abnormal respiratory motile cilium physiology (HP:0012261)5.14357899
7Rhinitis (HP:0012384)4.52859788
8Abnormal ciliary motility (HP:0012262)4.34332479
9Tubulointerstitial nephritis (HP:0001970)4.34235821
10Calcaneovalgus deformity (HP:0001848)4.32243281
11Deformed tarsal bones (HP:0008119)3.89030277
12Chronic bronchitis (HP:0004469)3.74125377
13Infertility (HP:0000789)3.33270271
14Abnormal mitochondria in muscle tissue (HP:0008316)3.10778356
15Synostosis involving the elbow (HP:0003938)3.03096335
16Humeroradial synostosis (HP:0003041)3.03096335
17Overriding aorta (HP:0002623)2.99477022
18Microglossia (HP:0000171)2.99251763
19Medial flaring of the eyebrow (HP:0010747)2.98096919
20Megalencephaly (HP:0001355)2.96610665
21Acute necrotizing encephalopathy (HP:0006965)2.95751338
22Split foot (HP:0001839)2.84845115
23Gait imbalance (HP:0002141)2.81502368
24Congenital primary aphakia (HP:0007707)2.75877365
25Progressive macrocephaly (HP:0004481)2.65705397
26Nasal polyposis (HP:0100582)2.62803778
27Poor suck (HP:0002033)2.56716202
28Abnormal spermatogenesis (HP:0008669)2.55209971
29Chronic otitis media (HP:0000389)2.49693467
30Nephrogenic diabetes insipidus (HP:0009806)2.46428553
31Toxemia of pregnancy (HP:0100603)2.46341933
32Truncal ataxia (HP:0002078)2.43143865
33Bronchiectasis (HP:0002110)2.41272322
34Acute encephalopathy (HP:0006846)2.38901999
35Arterial tortuosity (HP:0005116)2.35919311
36Sensory axonal neuropathy (HP:0003390)2.35688054
37Renovascular hypertension (HP:0100817)2.34887997
38Polygenic inheritance (HP:0010982)2.33753814
39Abnormality of the nasal mucosa (HP:0000433)2.32195895
40Type 2 muscle fiber atrophy (HP:0003554)2.27972087
41Hypoplastic pelvis (HP:0008839)2.26595876
42Abnormality of the carotid arteries (HP:0005344)2.26075395
43Hepatic necrosis (HP:0002605)2.23581785
44Neurofibrillary tangles (HP:0002185)2.20827310
45Large eyes (HP:0001090)2.17938459
46Tubulointerstitial abnormality (HP:0001969)2.16702294
47Myoglobinuria (HP:0002913)2.15948628
48Vaginal atresia (HP:0000148)2.14888746
49Insomnia (HP:0100785)2.12969504
50Abnormality of the calcaneus (HP:0008364)2.12769012
51Mitochondrial inheritance (HP:0001427)2.12130251
52Broad distal phalanx of finger (HP:0009836)2.08268072
53Hepatocellular necrosis (HP:0001404)2.08147787
54Genital tract atresia (HP:0001827)2.04860936
55Microvesicular hepatic steatosis (HP:0001414)2.04563268
56Gonadotropin excess (HP:0000837)2.03850882
57Hypothermia (HP:0002045)2.02966487
58Poor coordination (HP:0002370)2.02114159
59Vascular tortuosity (HP:0004948)2.02084090
60Muscle fiber atrophy (HP:0100295)2.00716734
61Optic nerve hypoplasia (HP:0000609)2.00414695
62Elfin facies (HP:0004428)1.98818827
63Adducted thumb (HP:0001181)1.98293387
64Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.97961000
65Decreased activity of mitochondrial respiratory chain (HP:0008972)1.97961000
66Increased CSF lactate (HP:0002490)1.96007110
67Oligomenorrhea (HP:0000876)1.95920171
68Aplasia/Hypoplasia of the lens (HP:0008063)1.94350156
69Nephronophthisis (HP:0000090)1.92620632
70Hyperacusis (HP:0010780)1.89972982
71Subcapsular cataract (HP:0000523)1.88945636
72Cerebral edema (HP:0002181)1.88394812
73Type I transferrin isoform profile (HP:0003642)1.88068407
74Tubular atrophy (HP:0000092)1.85589334
75Azoospermia (HP:0000027)1.84469396
76Methylmalonic aciduria (HP:0012120)1.83653203
77Abnormality of the diencephalon (HP:0010662)1.83010859
78Flat cornea (HP:0007720)1.82401075
79Retinal dysplasia (HP:0007973)1.81316574
80Ragged-red muscle fibers (HP:0003200)1.81255228
81Biconcave vertebral bodies (HP:0004586)1.75971399
82Respiratory distress (HP:0002098)1.74582417
83Abnormality of macular pigmentation (HP:0008002)1.74192857
84Renal duplication (HP:0000075)1.73927199
85Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.73780436
86Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.73348745
87Dicarboxylic aciduria (HP:0003215)1.72367555
88Abnormality of dicarboxylic acid metabolism (HP:0010995)1.72367555
89Brushfield spots (HP:0001088)1.71197136
90Respiratory failure (HP:0002878)1.69291828
91Recurrent otitis media (HP:0000403)1.69149701
92Increased serum pyruvate (HP:0003542)1.67888724
93Abnormality of glycolysis (HP:0004366)1.67888724
94Keratoconus (HP:0000563)1.67540921
95Increased corneal curvature (HP:0100692)1.67540921
96Ankle clonus (HP:0011448)1.65793068
97Male infertility (HP:0003251)1.64752195
98Increased muscle lipid content (HP:0009058)1.64555834
99Broad metatarsal (HP:0001783)1.63826712
100Bronchomalacia (HP:0002780)1.62402930

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.51616478
2PDK48.51616478
3PDK25.23170608
4LMTK24.53688536
5TESK12.47175622
6PRKD32.42434837
7STK161.98517312
8YES11.60510214
9IRAK11.41784977
10PHKG21.32419221
11PHKG11.32419221
12PTK2B1.26514387
13TIE11.18263584
14PINK11.17687069
15GRK11.17427099
16PRPF4B1.17379094
17MAP2K61.13580532
18FGFR21.13357210
19CDK81.08608074
20CASK1.06817733
21PRKG21.05556571
22STK38L1.04695744
23IRAK20.99236646
24PLK40.96400119
25SGK2230.91000977
26SGK4940.91000977
27MINK10.90879139
28MAPK130.90080869
29WNK40.88027933
30PASK0.85976772
31SGK20.84601195
32STK240.81386054
33RIPK40.77755656
34LIMK10.77419204
35TAOK20.74033028
36WEE10.71327957
37PLK20.70943276
38ACVR1B0.70875553
39CSF1R0.67484557
40BCKDK0.67124964
41ZAP700.63568433
42PIK3CG0.59942971
43STK380.56081668
44PDGFRB0.54301277
45STK30.51941819
46KDR0.51866186
47MAP3K110.50970048
48ERBB30.49092641
49EPHB20.48882524
50DAPK20.47932218
51PDK10.46868441
52TSSK60.46793003
53MAP4K10.45720860
54PRKCG0.42506579
55DYRK20.41882482
56PRKCH0.41756478
57ZAK0.41627203
58MET0.41326326
59SIK10.39925231
60EPHA40.39644233
61BUB10.39459755
62LATS20.38705965
63NTRK20.38071993
64WNK10.37764060
65NEK10.35163119
66FGR0.32934510
67SGK30.31843656
68MAP3K90.31304246
69MYLK0.30535505
70DAPK10.29788594
71TTK0.29669702
72RPS6KB10.29023432
73MAP3K120.28921775
74FER0.28577812
75ROCK10.26629470
76PRKCQ0.25080851
77PRKCE0.24761242
78GRK50.24633556
79DYRK1A0.23359036
80VRK10.21899579
81ADRBK20.21706400
82STK390.21609541
83NME20.20738514
84PRKCZ0.20683242
85PRKACG0.20501824
86CDK50.20224905
87ATR0.19523644
88SCYL20.19109272
89PRKCD0.18008099
90MAPK150.17243203
91IGF1R0.16588334
92DYRK1B0.15051604
93CAMK2A0.14739460
94FLT30.14463986
95RET0.14146780
96CSNK2A10.13834677
97AKT30.13608969
98PAK30.13492353
99PRKACA0.13084650
100PAK40.12198245

Predicted pathways (KEGG)

RankGene SetZ-score
1Propanoate metabolism_Homo sapiens_hsa006403.68098918
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.65294090
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.47087247
4Fatty acid biosynthesis_Homo sapiens_hsa000613.37484439
5Pyruvate metabolism_Homo sapiens_hsa006203.16263371
6Vitamin B6 metabolism_Homo sapiens_hsa007503.04555169
7Fatty acid degradation_Homo sapiens_hsa000713.01055532
8Fatty acid metabolism_Homo sapiens_hsa012122.90772602
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.90408144
10Fatty acid elongation_Homo sapiens_hsa000622.60969956
11Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.35522953
12Carbon metabolism_Homo sapiens_hsa012002.32156738
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.94091242
14Pentose phosphate pathway_Homo sapiens_hsa000301.89212304
15Oxidative phosphorylation_Homo sapiens_hsa001901.83082142
16PPAR signaling pathway_Homo sapiens_hsa033201.82554688
17Cysteine and methionine metabolism_Homo sapiens_hsa002701.78637827
18Biosynthesis of amino acids_Homo sapiens_hsa012301.75112654
19Peroxisome_Homo sapiens_hsa041461.73548501
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.72772432
21Steroid biosynthesis_Homo sapiens_hsa001001.69328530
22Parkinsons disease_Homo sapiens_hsa050121.64641544
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.62441399
24Sulfur metabolism_Homo sapiens_hsa009201.57991152
25Huntingtons disease_Homo sapiens_hsa050161.56118041
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.44867485
27Butanoate metabolism_Homo sapiens_hsa006501.43561398
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.40789363
29Alzheimers disease_Homo sapiens_hsa050101.25901810
30Cardiac muscle contraction_Homo sapiens_hsa042601.17487200
31N-Glycan biosynthesis_Homo sapiens_hsa005101.09867326
32Basal transcription factors_Homo sapiens_hsa030221.07740535
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.07013932
34DNA replication_Homo sapiens_hsa030301.06445937
35Collecting duct acid secretion_Homo sapiens_hsa049661.03393549
36Homologous recombination_Homo sapiens_hsa034401.02342458
37Synaptic vesicle cycle_Homo sapiens_hsa047210.98948920
38Proteasome_Homo sapiens_hsa030500.98464665
39Mineral absorption_Homo sapiens_hsa049780.98407664
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.98027691
41Glycerophospholipid metabolism_Homo sapiens_hsa005640.97846480
42Pyrimidine metabolism_Homo sapiens_hsa002400.95654092
43Metabolic pathways_Homo sapiens_hsa011000.92334275
44Glucagon signaling pathway_Homo sapiens_hsa049220.92137431
45Fructose and mannose metabolism_Homo sapiens_hsa000510.87035624
46Mismatch repair_Homo sapiens_hsa034300.86195200
47Drug metabolism - other enzymes_Homo sapiens_hsa009830.84006111
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.82196981
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.80280743
50beta-Alanine metabolism_Homo sapiens_hsa004100.79082455
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.78491236
52Nucleotide excision repair_Homo sapiens_hsa034200.77867032
53Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.77014658
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.76094007
55Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73174011
56Fanconi anemia pathway_Homo sapiens_hsa034600.72622226
57Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.71916425
58Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70623669
59Selenocompound metabolism_Homo sapiens_hsa004500.69909515
60Glycosaminoglycan degradation_Homo sapiens_hsa005310.69242815
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68261461
62Glycerolipid metabolism_Homo sapiens_hsa005610.68036662
63Insulin secretion_Homo sapiens_hsa049110.62202995
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60780697
65Taste transduction_Homo sapiens_hsa047420.60517930
66Purine metabolism_Homo sapiens_hsa002300.59916529
67Vibrio cholerae infection_Homo sapiens_hsa051100.59328899
68Ether lipid metabolism_Homo sapiens_hsa005650.58032223
69Sphingolipid metabolism_Homo sapiens_hsa006000.56541397
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56152078
71Oocyte meiosis_Homo sapiens_hsa041140.55796502
72Thyroid hormone synthesis_Homo sapiens_hsa049180.55344704
73Amphetamine addiction_Homo sapiens_hsa050310.50380198
74Linoleic acid metabolism_Homo sapiens_hsa005910.49733319
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49260619
76Glutamatergic synapse_Homo sapiens_hsa047240.45341496
77Inositol phosphate metabolism_Homo sapiens_hsa005620.45204328
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44439953
79Glutathione metabolism_Homo sapiens_hsa004800.41524655
80Tryptophan metabolism_Homo sapiens_hsa003800.40587465
81Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39320579
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38289699
83Salivary secretion_Homo sapiens_hsa049700.37544164
84Starch and sucrose metabolism_Homo sapiens_hsa005000.37005874
85Gastric acid secretion_Homo sapiens_hsa049710.35178614
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.34437019
87Long-term potentiation_Homo sapiens_hsa047200.33670426
88Bile secretion_Homo sapiens_hsa049760.29876781
89Calcium signaling pathway_Homo sapiens_hsa040200.27956134
90Cyanoamino acid metabolism_Homo sapiens_hsa004600.27261562
91Galactose metabolism_Homo sapiens_hsa000520.27051373
92Pancreatic secretion_Homo sapiens_hsa049720.26095947
93Circadian entrainment_Homo sapiens_hsa047130.25660512
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24682949
95Nicotine addiction_Homo sapiens_hsa050330.20660604
96Arachidonic acid metabolism_Homo sapiens_hsa005900.19853134
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.19681505
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.18750726
99Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.17071464
100Basal cell carcinoma_Homo sapiens_hsa052170.16345614

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