NPRL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1auditory behavior (GO:0031223)6.42710023
2mechanosensory behavior (GO:0007638)5.87933237
3startle response (GO:0001964)5.70376846
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.71671262
5chaperone-mediated protein transport (GO:0072321)4.57736468
6synaptic vesicle exocytosis (GO:0016079)4.55943352
7mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.50213545
8mannosylation (GO:0097502)4.43964201
9response to auditory stimulus (GO:0010996)4.40507954
10tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.36125611
11RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.36125611
12energy coupled proton transport, down electrochemical gradient (GO:0015985)4.34592160
13ATP synthesis coupled proton transport (GO:0015986)4.34592160
14energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.33248108
15ATP hydrolysis coupled proton transport (GO:0015991)4.33248108
16peptidyl-histidine modification (GO:0018202)4.31716575
17NADH metabolic process (GO:0006734)4.31167174
18protein complex biogenesis (GO:0070271)4.28651544
19neuron cell-cell adhesion (GO:0007158)4.17084087
20innervation (GO:0060384)4.08214675
21ubiquinone biosynthetic process (GO:0006744)3.96141560
22protein deneddylation (GO:0000338)3.92770596
23metallo-sulfur cluster assembly (GO:0031163)3.91973466
24iron-sulfur cluster assembly (GO:0016226)3.91973466
25transferrin transport (GO:0033572)3.88260666
26mitochondrial respiratory chain complex assembly (GO:0033108)3.87995168
27cullin deneddylation (GO:0010388)3.85304724
28protein localization to synapse (GO:0035418)3.82737306
29respiratory electron transport chain (GO:0022904)3.82431632
30establishment of protein localization to mitochondrial membrane (GO:0090151)3.80557529
31GMP metabolic process (GO:0046037)3.80322367
32ubiquinone metabolic process (GO:0006743)3.77320967
33mitochondrial respiratory chain complex I assembly (GO:0032981)3.76235620
34NADH dehydrogenase complex assembly (GO:0010257)3.76235620
35mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.76235620
36regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.76077388
37preassembly of GPI anchor in ER membrane (GO:0016254)3.75439081
38presynaptic membrane assembly (GO:0097105)3.75432640
39electron transport chain (GO:0022900)3.75156807
40cochlea development (GO:0090102)3.73668461
41synaptic vesicle docking involved in exocytosis (GO:0016081)3.73374003
42serotonin receptor signaling pathway (GO:0007210)3.71258601
43regulation of short-term neuronal synaptic plasticity (GO:0048172)3.69833854
44negative regulation of telomere maintenance (GO:0032205)3.67236870
45platelet dense granule organization (GO:0060155)3.59927580
46mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.58244154
47positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.53990021
48ferric iron transport (GO:0015682)3.53562922
49trivalent inorganic cation transport (GO:0072512)3.53562922
50nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.53242791
51L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.50401843
52base-excision repair, AP site formation (GO:0006285)3.46986297
53rRNA modification (GO:0000154)3.46499634
54GPI anchor biosynthetic process (GO:0006506)3.45839919
55postsynaptic membrane organization (GO:0001941)3.44576665
56regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.42338795
57oxaloacetate metabolic process (GO:0006107)3.41133541
58presynaptic membrane organization (GO:0097090)3.39990811
59DNA damage response, detection of DNA damage (GO:0042769)3.39691321
60exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.39344131
61vocalization behavior (GO:0071625)3.38640822
62nonmotile primary cilium assembly (GO:0035058)3.38593005
63glutamate secretion (GO:0014047)3.37664617
64quinone biosynthetic process (GO:1901663)3.35336497
65deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.34570414
66regulation of glutamate receptor signaling pathway (GO:1900449)3.33598950
67gamma-aminobutyric acid signaling pathway (GO:0007214)3.31352691
68dopamine transport (GO:0015872)3.30115252
69inner mitochondrial membrane organization (GO:0007007)3.27831889
70negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.27170667
71cytochrome complex assembly (GO:0017004)3.26431903
72GPI anchor metabolic process (GO:0006505)3.25730055
73DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.24742777
74neurotransmitter secretion (GO:0007269)3.22013711
75regulation of cilium movement (GO:0003352)3.21739737
76C-terminal protein amino acid modification (GO:0018410)3.19951349
77succinate metabolic process (GO:0006105)3.19947551
78regulation of cellular amino acid metabolic process (GO:0006521)3.18939844
79C-terminal protein lipidation (GO:0006501)3.18552009
80neurotransmitter-gated ion channel clustering (GO:0072578)3.18309949
81tricarboxylic acid cycle (GO:0006099)3.17213032
82regulation of synaptic vesicle transport (GO:1902803)3.16891055
83striatum development (GO:0021756)3.15592353
84respiratory chain complex IV assembly (GO:0008535)3.15055875
85regulation of synaptic vesicle exocytosis (GO:2000300)3.14453033
86dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.13617938
87tRNA processing (GO:0008033)3.12968738
88signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.12411678
89signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.12411678
90signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.12411678
91positive regulation of mitochondrial fission (GO:0090141)3.11900600
92negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.11027259
93intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.10756470
94signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.10756470
95reflex (GO:0060004)3.08849269
96DNA deamination (GO:0045006)3.08425950
97hydrogen ion transmembrane transport (GO:1902600)3.07638681
98termination of RNA polymerase III transcription (GO:0006386)3.06665983
99transcription elongation from RNA polymerase III promoter (GO:0006385)3.06665983
100amino acid salvage (GO:0043102)3.06379287
101L-methionine salvage (GO:0071267)3.06379287
102L-methionine biosynthetic process (GO:0071265)3.06379287
103cell morphogenesis involved in neuron differentiation (GO:0048667)3.05933967
104regulation of oxidative phosphorylation (GO:0002082)3.04166957
105negative regulation of synaptic transmission, GABAergic (GO:0032229)3.04067032
106positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.01794787
107protein-cofactor linkage (GO:0018065)3.01295203
108neuron-neuron synaptic transmission (GO:0007270)3.01291448
109signal transduction involved in cell cycle checkpoint (GO:0072395)3.00078033
110regulation of mitochondrial translation (GO:0070129)2.96620831
111neurotransmitter uptake (GO:0001504)2.95752260
112tRNA metabolic process (GO:0006399)2.95745742
113signal transduction involved in DNA damage checkpoint (GO:0072422)2.95431576
114signal transduction involved in DNA integrity checkpoint (GO:0072401)2.95431576
115mitochondrial fission (GO:0000266)2.92428441
116positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.91866237
117regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.91342898
118regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.91342898
119protein localization to mitochondrion (GO:0070585)2.90771015
120neuronal action potential propagation (GO:0019227)2.90431158
121intracellular protein transmembrane import (GO:0044743)2.89572401
122tRNA aminoacylation for protein translation (GO:0006418)2.89148846
123oxidative demethylation (GO:0070989)2.87385796
124negative regulation of ligase activity (GO:0051352)2.87292754
125negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.87292754
126water-soluble vitamin biosynthetic process (GO:0042364)2.87128308
127synaptic transmission, glutamatergic (GO:0035249)2.85797524
128regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.85790303
129amino acid activation (GO:0043038)2.84642061
130tRNA aminoacylation (GO:0043039)2.84642061
131neurotransmitter transport (GO:0006836)2.84442796
132negative regulation of DNA-templated transcription, elongation (GO:0032785)2.83551773
133phagosome maturation (GO:0090382)2.82527700
134proton transport (GO:0015992)2.82044391
135adenosine metabolic process (GO:0046085)2.80702300
136protein localization to cilium (GO:0061512)2.80499889
137regulation of inositol phosphate biosynthetic process (GO:0010919)2.79716742
138pseudouridine synthesis (GO:0001522)2.78929845
139cell wall macromolecule catabolic process (GO:0016998)2.77646279
140purine nucleoside triphosphate biosynthetic process (GO:0009145)2.77573426
141synapse assembly (GO:0007416)2.77265727
142positive regulation of protein homodimerization activity (GO:0090073)2.76686527
143hydrogen transport (GO:0006818)2.76572135
144purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.76407299
145peroxisome fission (GO:0016559)2.76035446
146proteasome assembly (GO:0043248)2.75277672
147protein targeting to mitochondrion (GO:0006626)2.74580786
148aldehyde catabolic process (GO:0046185)2.74557876
149synaptic vesicle transport (GO:0048489)2.74479020
150establishment of synaptic vesicle localization (GO:0097480)2.74479020
151pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.74148143
152purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.73563022
153positive regulation of synapse assembly (GO:0051965)2.73453162
154rRNA methylation (GO:0031167)2.73066004
155purine deoxyribonucleotide metabolic process (GO:0009151)2.71650708
156intracellular protein transmembrane transport (GO:0065002)2.70134655
157positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.69763121
158DNA double-strand break processing (GO:0000729)2.69556119
159serotonin metabolic process (GO:0042428)2.66536943
160positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.64851338
161glutamate receptor signaling pathway (GO:0007215)2.64191905
162positive regulation of synaptic transmission, GABAergic (GO:0032230)2.63249340
163protein neddylation (GO:0045116)2.61538088
164catecholamine transport (GO:0051937)2.60761115
165regulation of phospholipid biosynthetic process (GO:0071071)2.59932032
166regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.59468637
167ionotropic glutamate receptor signaling pathway (GO:0035235)2.58439351
168regulation of neurotransmitter levels (GO:0001505)2.58363127
169establishment of protein localization to mitochondrion (GO:0072655)2.58115432
170ATP biosynthetic process (GO:0006754)2.57344210
171lactate metabolic process (GO:0006089)2.56932190

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.24779379
2GBX2_23144817_ChIP-Seq_PC3_Human3.83512503
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.98525967
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.98438798
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.88495146
6TAF15_26573619_Chip-Seq_HEK293_Human2.83546161
7GABP_19822575_ChIP-Seq_HepG2_Human2.63312919
8CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.55756593
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.49528953
10REST_21632747_ChIP-Seq_MESCs_Mouse2.43250148
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.39109922
12THAP11_20581084_ChIP-Seq_MESCs_Mouse2.34833672
13PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.34389668
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.29039747
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.26508848
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.23301676
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.21883836
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.20146955
19REST_18959480_ChIP-ChIP_MESCs_Mouse2.18265857
20SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.18236745
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.16560797
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.15629752
23ELK1_19687146_ChIP-ChIP_HELA_Human2.13682038
24DCP1A_22483619_ChIP-Seq_HELA_Human2.13582418
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.12813072
26XRN2_22483619_ChIP-Seq_HELA_Human2.10071889
27PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.00041637
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.99498754
29SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.97553335
30MYC_18555785_ChIP-Seq_MESCs_Mouse1.95335887
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.92694100
32ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.91247104
33* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.90873274
34JARID2_20064375_ChIP-Seq_MESCs_Mouse1.87590350
35SRF_21415370_ChIP-Seq_HL-1_Mouse1.86800119
36TTF2_22483619_ChIP-Seq_HELA_Human1.82029983
37CIITA_25753668_ChIP-Seq_RAJI_Human1.79484796
38VDR_22108803_ChIP-Seq_LS180_Human1.77698870
39BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.74854932
40FUS_26573619_Chip-Seq_HEK293_Human1.74063722
41E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.72548168
42ETS1_20019798_ChIP-Seq_JURKAT_Human1.70175380
43EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.67443187
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.67348812
45* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.66256022
46EZH2_27304074_Chip-Seq_ESCs_Mouse1.65221640
47NOTCH1_21737748_ChIP-Seq_TLL_Human1.65129513
48MYC_18940864_ChIP-ChIP_HL60_Human1.64399683
49P300_19829295_ChIP-Seq_ESCs_Human1.63468365
50MYC_19030024_ChIP-ChIP_MESCs_Mouse1.62456847
51IKZF1_21737484_ChIP-ChIP_HCT116_Human1.61099709
52ELF1_17652178_ChIP-ChIP_JURKAT_Human1.60880647
53JARID2_20075857_ChIP-Seq_MESCs_Mouse1.60294682
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.58722513
55BMI1_23680149_ChIP-Seq_NPCS_Mouse1.57984137
56SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.57280479
57SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.55942093
58BP1_19119308_ChIP-ChIP_Hs578T_Human1.55610855
59FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.55259071
60IGF1R_20145208_ChIP-Seq_DFB_Human1.55226115
61SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.55142896
62E2F1_18555785_ChIP-Seq_MESCs_Mouse1.55091863
63NELFA_20434984_ChIP-Seq_ESCs_Mouse1.54519964
64KDM5A_27292631_Chip-Seq_BREAST_Human1.54426520
65SMAD4_21799915_ChIP-Seq_A2780_Human1.49256720
66GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48867201
67SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.47538234
68SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.47209570
69EED_16625203_ChIP-ChIP_MESCs_Mouse1.47146077
70RARB_27405468_Chip-Seq_BRAIN_Mouse1.45586845
71PADI4_21655091_ChIP-ChIP_MCF-7_Human1.45264461
72CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.45070796
73IRF1_19129219_ChIP-ChIP_H3396_Human1.41638434
74RNF2_27304074_Chip-Seq_NSC_Mouse1.40608944
75CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.40520471
76CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.40044097
77MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.37769305
78CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.37600720
79CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.33813417
80ESR1_15608294_ChIP-ChIP_MCF-7_Human1.33029618
81MTF2_20144788_ChIP-Seq_MESCs_Mouse1.32787350
82POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.32435855
83YY1_21170310_ChIP-Seq_MESCs_Mouse1.32401308
84FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31323810
85CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.30778390
86TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.29836656
87TP53_22573176_ChIP-Seq_HFKS_Human1.29742431
88EWS_26573619_Chip-Seq_HEK293_Human1.28395872
89ZNF274_21170338_ChIP-Seq_K562_Hela1.28197439
90CREB1_15753290_ChIP-ChIP_HEK293T_Human1.26954885
91OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26081115
92DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.24564239
93SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.24514490
94CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.23310643
95SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.22154969
96UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21342808
97TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19876958
98CBX2_27304074_Chip-Seq_ESCs_Mouse1.19830695
99EZH2_18974828_ChIP-Seq_MESCs_Mouse1.19710746
100RNF2_18974828_ChIP-Seq_MESCs_Mouse1.19710746
101SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18860680
102ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.18157577
103RBPJ_22232070_ChIP-Seq_NCS_Mouse1.17506690
104SUZ12_27294783_Chip-Seq_ESCs_Mouse1.15045623
105EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.14214877
106MYC_19079543_ChIP-ChIP_MESCs_Mouse1.14088883
107E2F4_17652178_ChIP-ChIP_JURKAT_Human1.13497720
108PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.12957948
109IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.12844825
110EZH2_27294783_Chip-Seq_ESCs_Mouse1.12427853
111AR_25329375_ChIP-Seq_VCAP_Human1.12283508
112MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.12128798
113PIAS1_25552417_ChIP-Seq_VCAP_Human1.12038620
114MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11817784
115SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.11546097
116JUN_21703547_ChIP-Seq_K562_Human1.11149654
117MYCN_18555785_ChIP-Seq_MESCs_Mouse1.10941367
118TAL1_26923725_Chip-Seq_HPCs_Mouse1.10353496
119NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09143739
120ELK1_22589737_ChIP-Seq_MCF10A_Human1.09072200
121FOXP1_21924763_ChIP-Seq_HESCs_Human1.08847383
122SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08427543
123SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07058480
124HTT_18923047_ChIP-ChIP_STHdh_Human1.06947718
125IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06927221
126CBP_20019798_ChIP-Seq_JUKART_Human1.06927221
127SMAD3_21741376_ChIP-Seq_EPCs_Human1.05796190
128ERG_20887958_ChIP-Seq_HPC-7_Mouse1.05794996
129PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.05002137
130SOX2_21211035_ChIP-Seq_LN229_Gbm1.04413542
131SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.03743001
132RNF2_27304074_Chip-Seq_ESCs_Mouse1.03731835
133ELF1_20517297_ChIP-Seq_JURKAT_Human1.03123203
134CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.02829152
135MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.02707262
136E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02315663
137ERA_21632823_ChIP-Seq_H3396_Human0.99315003
138PRDM14_20953172_ChIP-Seq_ESCs_Human0.96378711
139BCL6_27268052_Chip-Seq_Bcells_Human0.96044904
140YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95517714
141GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95205340
142ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.94357087
143ER_23166858_ChIP-Seq_MCF-7_Human0.94350758
144REST_19997604_ChIP-ChIP_NEURONS_Mouse0.92963602
145FOXP3_21729870_ChIP-Seq_TREG_Human0.92878200
146MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.92108645
147POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.91776141
148FLI1_27457419_Chip-Seq_LIVER_Mouse0.91453513
149TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.90054234
150* VDR_23849224_ChIP-Seq_CD4+_Human0.89769063
151RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.89756559
152GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89313245
153PCGF2_27294783_Chip-Seq_ESCs_Mouse0.88822534
154MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88634737
155NCOR_22424771_ChIP-Seq_293T_Human0.87299011
156YY1_22570637_ChIP-Seq_MALME-3M_Human0.86759916
157HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.85924114
158FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.85822486
159EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.85798772
160CTCF_20526341_ChIP-Seq_ESCs_Human0.81820093
161CTCF_18555785_ChIP-Seq_MESCs_Mouse0.81147939
162FOXA1_25329375_ChIP-Seq_VCAP_Human0.80233196
163FOXA1_27270436_Chip-Seq_PROSTATE_Human0.80233196
164ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.80018311
165DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.79792188
166CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.78959504
167NANOG_20526341_ChIP-Seq_ESCs_Human0.78335658

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.18786181
2MP0002736_abnormal_nociception_after4.12070581
3MP0004859_abnormal_synaptic_plasticity3.92762579
4MP0001968_abnormal_touch/_nociception3.56033463
5MP0001529_abnormal_vocalization3.25475830
6MP0003635_abnormal_synaptic_transmissio3.13034516
7MP0009745_abnormal_behavioral_response2.80165366
8MP0002064_seizures2.72111948
9MP0003122_maternal_imprinting2.68972581
10MP0008058_abnormal_DNA_repair2.68061177
11MP0002063_abnormal_learning/memory/cond2.58632018
12MP0002572_abnormal_emotion/affect_behav2.55539282
13MP0002837_dystrophic_cardiac_calcinosis2.53287426
14MP0006276_abnormal_autonomic_nervous2.50957400
15MP0003806_abnormal_nucleotide_metabolis2.49601254
16MP0009046_muscle_twitch2.49381196
17MP0004270_analgesia2.49190840
18MP0002822_catalepsy2.48542677
19MP0001905_abnormal_dopamine_level2.43213795
20MP0002272_abnormal_nervous_system2.23381132
21MP0004147_increased_porphyrin_level2.17717279
22MP0001984_abnormal_olfaction2.15156075
23MP0005646_abnormal_pituitary_gland2.11292108
24MP0002734_abnormal_mechanical_nocicepti2.08765553
25MP0006035_abnormal_mitochondrial_morpho2.03527242
26MP0002733_abnormal_thermal_nociception1.99950181
27MP0001970_abnormal_pain_threshold1.92838983
28MP0008995_early_reproductive_senescence1.89919653
29MP0003786_premature_aging1.87437515
30MP0002067_abnormal_sensory_capabilities1.85263179
31MP0001502_abnormal_circadian_rhythm1.84267270
32MP0002735_abnormal_chemical_nociception1.81919818
33MP0002184_abnormal_innervation1.79718923
34MP0002876_abnormal_thyroid_physiology1.75108224
35MP0006036_abnormal_mitochondrial_physio1.67430801
36MP0003121_genomic_imprinting1.66525946
37MP0000372_irregular_coat_pigmentation1.65806912
38MP0004142_abnormal_muscle_tone1.64759267
39MP0003011_delayed_dark_adaptation1.63593662
40MP0001501_abnormal_sleep_pattern1.60238979
41MP0002132_abnormal_respiratory_system1.59137038
42MP0010386_abnormal_urinary_bladder1.57894244
43MP0005075_abnormal_melanosome_morpholog1.56928750
44MP0004924_abnormal_behavior1.56787474
45MP0005386_behavior/neurological_phenoty1.56787474
46MP0003329_amyloid_beta_deposits1.55279623
47MP0005423_abnormal_somatic_nervous1.52921782
48MP0001486_abnormal_startle_reflex1.52508929
49MP0003186_abnormal_redox_activity1.52091778
50MP0004043_abnormal_pH_regulation1.44216916
51MP0001440_abnormal_grooming_behavior1.43399878
52MP0003646_muscle_fatigue1.41894482
53MP0002557_abnormal_social/conspecific_i1.39487500
54MP0005171_absent_coat_pigmentation1.38740380
55MP0008569_lethality_at_weaning1.37974742
56MP0005671_abnormal_response_to1.37383533
57MP0002938_white_spotting1.33347404
58MP0003693_abnormal_embryo_hatching1.32457710
59MP0009697_abnormal_copulation1.31956601
60MP0005379_endocrine/exocrine_gland_phen1.28766348
61MP0000778_abnormal_nervous_system1.27340767
62MP0004811_abnormal_neuron_physiology1.24963910
63MP0006054_spinal_hemorrhage1.22881226
64MP0001986_abnormal_taste_sensitivity1.20823820
65MP0002066_abnormal_motor_capabilities/c1.20361341
66MP0002638_abnormal_pupillary_reflex1.16401982
67MP0005084_abnormal_gallbladder_morpholo1.16080410
68MP0005253_abnormal_eye_physiology1.11040727
69MP0000015_abnormal_ear_pigmentation1.09828209
70MP0003787_abnormal_imprinting1.09120649
71MP0005310_abnormal_salivary_gland1.07911613
72MP0004133_heterotaxia1.07382612
73MP0004215_abnormal_myocardial_fiber1.05368309
74MP0001188_hyperpigmentation1.04928924
75MP0002095_abnormal_skin_pigmentation1.03505938
76MP0000013_abnormal_adipose_tissue1.03042624
77MP0000955_abnormal_spinal_cord1.02737793
78MP0000631_abnormal_neuroendocrine_gland0.99763915
79MP0004145_abnormal_muscle_electrophysio0.99737444
80MP0000516_abnormal_urinary_system0.99154416
81MP0005367_renal/urinary_system_phenotyp0.99154416
82MP0008260_abnormal_autophagy0.99055846
83MP0003879_abnormal_hair_cell0.98283186
84MP0005499_abnormal_olfactory_system0.97808563
85MP0005394_taste/olfaction_phenotype0.97808563
86MP0003195_calcinosis0.97227451
87MP0000751_myopathy0.96462292
88MP0002882_abnormal_neuron_morphology0.95008919
89MP0002102_abnormal_ear_morphology0.94790815
90MP0002069_abnormal_eating/drinking_beha0.94724989
91MP0005332_abnormal_amino_acid0.94376443
92MP0010234_abnormal_vibrissa_follicle0.94027055
93MP0008872_abnormal_physiological_respon0.93788816
94MP0001929_abnormal_gametogenesis0.93045538
95MP0008007_abnormal_cellular_replicative0.92901102
96MP0005645_abnormal_hypothalamus_physiol0.91365723
97MP0004742_abnormal_vestibular_system0.91200374
98MP0008875_abnormal_xenobiotic_pharmacok0.90951688
99MP0005535_abnormal_body_temperature0.89043330
100MP0004858_abnormal_nervous_system0.88598804
101MP0003698_abnormal_male_reproductive0.88559828
102MP0002210_abnormal_sex_determination0.86445724
103MP0008961_abnormal_basal_metabolism0.86052407
104MP0001963_abnormal_hearing_physiology0.84943380
105MP0002277_abnormal_respiratory_mucosa0.83390363
106MP0002229_neurodegeneration0.82975981
107MP0003633_abnormal_nervous_system0.82570019
108MP0005551_abnormal_eye_electrophysiolog0.81811376
109MP0006292_abnormal_olfactory_placode0.81367370
110MP0003718_maternal_effect0.81251797
111MP0005410_abnormal_fertilization0.81022544
112MP0001664_abnormal_digestion0.80676164
113MP0005266_abnormal_metabolism0.80321381
114MP0010094_abnormal_chromosome_stability0.79608728
115MP0003631_nervous_system_phenotype0.78121063
116MP0004036_abnormal_muscle_relaxation0.78033128
117MP0001800_abnormal_humoral_immune0.75404569
118MP0008789_abnormal_olfactory_epithelium0.75291022
119MP0000026_abnormal_inner_ear0.75167008
120MP0000689_abnormal_spleen_morphology0.75159816
121MP0002163_abnormal_gland_morphology0.74479455
122MP0003938_abnormal_ear_development0.74090870
123MP0001145_abnormal_male_reproductive0.72907432
124MP0003724_increased_susceptibility_to0.72485955
125MP0005083_abnormal_biliary_tract0.72311514
126MP0001919_abnormal_reproductive_system0.71813300
127MP0005365_abnormal_bile_salt0.71725533
128MP0001177_atelectasis0.71312614
129MP0001324_abnormal_eye_pigmentation0.69509843
130MP0004381_abnormal_hair_follicle0.69496721
131MP0002152_abnormal_brain_morphology0.68927697
132MP0002723_abnormal_immune_serum0.68496641
133MP0002160_abnormal_reproductive_system0.68493997
134MP0003077_abnormal_cell_cycle0.68140656
135MP0002752_abnormal_somatic_nervous0.67900862
136MP0003632_abnormal_nervous_system0.67800719
137MP0000653_abnormal_sex_gland0.67737905
138MP0008877_abnormal_DNA_methylation0.67084910
139MP0000358_abnormal_cell_content/0.66248428
140MP0005636_abnormal_mineral_homeostasis0.65934785
141MP0005448_abnormal_energy_balance0.62575555
142MP0000604_amyloidosis0.61998250
143MP0006072_abnormal_retinal_apoptosis0.61988126
144MP0002653_abnormal_ependyma_morphology0.61507844
145MP0001764_abnormal_homeostasis0.61396319
146MP0004130_abnormal_muscle_cell0.61334252

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.95070400
2Abnormal mitochondria in muscle tissue (HP:0008316)4.87643318
3Focal motor seizures (HP:0011153)4.73906215
4Mitochondrial inheritance (HP:0001427)4.39000199
5Progressive macrocephaly (HP:0004481)4.22502970
6Acute encephalopathy (HP:0006846)4.13229316
7Hepatocellular necrosis (HP:0001404)3.90792664
8Increased CSF lactate (HP:0002490)3.90254089
9Abnormal hair whorl (HP:0010721)3.75051443
10Hypothermia (HP:0002045)3.66090389
11Nephrogenic diabetes insipidus (HP:0009806)3.56839055
12Myokymia (HP:0002411)3.39319247
13Gait imbalance (HP:0002141)3.38351804
14Hepatic necrosis (HP:0002605)3.37081716
15Methylmalonic acidemia (HP:0002912)3.32509351
16Medial flaring of the eyebrow (HP:0010747)3.31867193
17Neuroendocrine neoplasm (HP:0100634)3.31652179
18Congenital primary aphakia (HP:0007707)3.24682300
19Failure to thrive in infancy (HP:0001531)3.23427391
20Pheochromocytoma (HP:0002666)3.20835009
21Hyperventilation (HP:0002883)3.12496177
22Methylmalonic aciduria (HP:0012120)3.10985086
23Atonic seizures (HP:0010819)3.10124399
24Poor suck (HP:0002033)3.06954110
25Abnormality of glycolysis (HP:0004366)3.01933534
26Increased serum pyruvate (HP:0003542)3.01933534
27Cerebral edema (HP:0002181)2.94794419
28Epileptic encephalopathy (HP:0200134)2.88229258
29Lactic acidosis (HP:0003128)2.84785212
30Increased hepatocellular lipid droplets (HP:0006565)2.80219185
31Abnormality of dicarboxylic acid metabolism (HP:0010995)2.70543330
32Dicarboxylic aciduria (HP:0003215)2.70543330
33Optic disc pallor (HP:0000543)2.60560305
34Lipid accumulation in hepatocytes (HP:0006561)2.59636659
35Focal seizures (HP:0007359)2.59095225
36Renal Fanconi syndrome (HP:0001994)2.57753422
37Poor coordination (HP:0002370)2.57734992
38Increased intramyocellular lipid droplets (HP:0012240)2.56967597
39Absence seizures (HP:0002121)2.55390537
40Molar tooth sign on MRI (HP:0002419)2.54737538
41Abnormality of midbrain morphology (HP:0002418)2.54737538
42Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.54509011
43Decreased activity of mitochondrial respiratory chain (HP:0008972)2.54509011
44Conjugated hyperbilirubinemia (HP:0002908)2.53936810
45Pancreatic cysts (HP:0001737)2.50588304
46Febrile seizures (HP:0002373)2.47965205
47Spastic gait (HP:0002064)2.47934174
48Vaginal atresia (HP:0000148)2.46980083
49Leukodystrophy (HP:0002415)2.43556877
50Genital tract atresia (HP:0001827)2.38670730
51Visual hallucinations (HP:0002367)2.38359433
52Type II lissencephaly (HP:0007260)2.38288162
53Progressive inability to walk (HP:0002505)2.37306211
54Exercise intolerance (HP:0003546)2.36971280
55Increased serum lactate (HP:0002151)2.35972626
56Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.35280267
57Oligomenorrhea (HP:0000876)2.34929403
58Congenital stationary night blindness (HP:0007642)2.33981774
59Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.33217867
60Pancreatic fibrosis (HP:0100732)2.31338171
61Cerebral hypomyelination (HP:0006808)2.30027685
62Renal cortical cysts (HP:0000803)2.29115779
63Polyphagia (HP:0002591)2.27968712
64Hypoplasia of the pons (HP:0012110)2.26918919
65Dialeptic seizures (HP:0011146)2.26207182
66Generalized tonic-clonic seizures (HP:0002069)2.23136398
67Respiratory failure (HP:0002878)2.22027693
68Emotional lability (HP:0000712)2.21992805
69Anxiety (HP:0000739)2.19076625
70Hyperglycinemia (HP:0002154)2.18871034
71Increased muscle lipid content (HP:0009058)2.18676856
72Abnormal protein glycosylation (HP:0012346)2.16682789
73Abnormal glycosylation (HP:0012345)2.16682789
74Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.16682789
75Abnormal protein N-linked glycosylation (HP:0012347)2.16682789
76Abnormality of the pons (HP:0007361)2.16291115
773-Methylglutaconic aciduria (HP:0003535)2.14665271
78Epileptiform EEG discharges (HP:0011182)2.14062575
79Exertional dyspnea (HP:0002875)2.13875742
80Decreased testicular size (HP:0008734)2.12614620
81Abnormal rod and cone electroretinograms (HP:0008323)2.12164206
82Esotropia (HP:0000565)2.12088497
83Delusions (HP:0000746)2.11859553
84Brushfield spots (HP:0001088)2.11786738
85Decreased electroretinogram (ERG) amplitude (HP:0000654)2.10438872
86Reduced antithrombin III activity (HP:0001976)2.09857718
87Hypokalemic alkalosis (HP:0001949)2.09178902
88Limb dystonia (HP:0002451)2.06367679
89Nephronophthisis (HP:0000090)2.03398508
90Type I transferrin isoform profile (HP:0003642)2.00794824
91Abnormality of the vitamin B12 metabolism (HP:0004341)2.00220608
92Inability to walk (HP:0002540)1.99496533
93Decreased circulating renin level (HP:0003351)1.98098844
94EEG with generalized epileptiform discharges (HP:0011198)1.97208756
95Abnormality of vitamin B metabolism (HP:0004340)1.96187508
96Abnormal gallbladder physiology (HP:0012438)1.94118510
97Cholecystitis (HP:0001082)1.94118510
98Abnormality of alanine metabolism (HP:0010916)1.91594025
99Hyperalaninemia (HP:0003348)1.91594025
100Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.91594025
101Attenuation of retinal blood vessels (HP:0007843)1.90504119
102Abnormal eating behavior (HP:0100738)1.87995627
103Broad foot (HP:0001769)1.87452518
104Hypsarrhythmia (HP:0002521)1.86119830
105Abnormality of serum amino acid levels (HP:0003112)1.85364977
106Ragged-red muscle fibers (HP:0003200)1.84228198
107IgG deficiency (HP:0004315)1.83793261
108True hermaphroditism (HP:0010459)1.83309737
109Abnormality of pain sensation (HP:0010832)1.83157776
110Impaired pain sensation (HP:0007328)1.83157776
111Poor eye contact (HP:0000817)1.83097495
112X-linked dominant inheritance (HP:0001423)1.82814039
113Aplasia/Hypoplasia of the lens (HP:0008063)1.82145317
114Unsteady gait (HP:0002317)1.81674000
115Aplastic anemia (HP:0001915)1.80879096
116Respiratory difficulties (HP:0002880)1.80439105
117Fair hair (HP:0002286)1.79933403
118Poor speech (HP:0002465)1.79713044
119Truncal ataxia (HP:0002078)1.78947138
120Sclerocornea (HP:0000647)1.77590642
121Microvesicular hepatic steatosis (HP:0001414)1.77006553
122Absent rod-and cone-mediated responses on ERG (HP:0007688)1.76767662
123Specific learning disability (HP:0001328)1.76579766
124Retinal dysplasia (HP:0007973)1.76254538
125Severe combined immunodeficiency (HP:0004430)1.76246260
126Hyperactive renin-angiotensin system (HP:0000841)1.75888188
127Cerebellar dysplasia (HP:0007033)1.75402619
128Lissencephaly (HP:0001339)1.74900629
129Chronic bronchitis (HP:0004469)1.73868584
130Lethargy (HP:0001254)1.73657607
131Progressive cerebellar ataxia (HP:0002073)1.72991910
132Progressive microcephaly (HP:0000253)1.72670663
133CNS demyelination (HP:0007305)1.72394273
134Pancytopenia (HP:0001876)1.71385550
135Abnormality of the labia minora (HP:0012880)1.71083957
136Acute hepatic failure (HP:0006554)1.69461269
137Upper limb muscle weakness (HP:0003484)1.69425852
138Retinitis pigmentosa (HP:0000510)1.66852901
139Abnormality of renal resorption (HP:0011038)1.66537544
140Generalized aminoaciduria (HP:0002909)1.62512841
141Adrenal hypoplasia (HP:0000835)1.61618210

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K125.03624859
2MAP4K24.62275832
3CASK3.65237994
4MAP2K73.29403586
5NTRK22.97267478
6MAP3K42.95780759
7VRK22.90939685
8TNIK2.87052994
9NEK12.83120953
10NTRK32.46313481
11CCNB12.33015199
12EIF2AK12.29002669
13MAP2K42.27793826
14TAOK32.27726068
15STK162.22939876
16CDK192.22624460
17SIK32.10359844
18PIM22.04379458
19DAPK12.00163838
20CSNK1G31.92388445
21ZAK1.73559692
22EPHA41.71020653
23CSNK1G21.65458137
24TSSK61.64751663
25MUSK1.64278916
26TESK21.56900105
27PLK21.53479772
28NUAK11.52448159
29BCKDK1.51398946
30OXSR11.47440528
31TESK11.43912820
32TLK11.42815653
33MINK11.39336041
34ARAF1.38250509
35SIK21.36725724
36BRAF1.33955389
37CSNK1A1L1.33813749
38MAPK131.32064767
39CSNK1G11.31994763
40LIMK11.31178315
41NME11.27938210
42FRK1.23411896
43WNK31.22956095
44NTRK11.14427628
45MYLK1.13553324
46DAPK21.13360828
47MARK11.12372531
48FER1.12170606
49AKT31.10658831
50MAP4K11.10641222
51UHMK11.04312719
52CDK81.04091427
53FLT31.03597082
54MST41.03043843
55FES1.02014025
56DYRK1B1.01929688
57MAP3K91.01299150
58EPHA30.99695605
59GRK50.99045836
60SRPK10.98580480
61CDK50.98337952
62GRK10.97520270
63PAK30.95589474
64LMTK20.93030860
65ERBB30.92950479
66CAMK2A0.92403176
67PRKCI0.92127915
68PRKCG0.91767371
69TRIM280.91506181
70RPS6KA50.90496746
71PASK0.88897520
72MAP2K60.88330864
73GRK70.86568829
74PAK40.86415469
75STK38L0.84515201
76CAMK2B0.84444750
77ADRBK20.84148771
78PRPF4B0.83485046
79IKBKE0.81600884
80PINK10.80023644
81PDK40.78116358
82PDK30.78116358
83SGK4940.78035509
84SGK2230.78035509
85INSRR0.77699394
86BMPR1B0.74346517
87PLK40.72999479
88BUB10.72696728
89VRK10.69925643
90MARK20.68518580
91BMPR20.67448760
92TNK20.66860773
93MAP3K50.65539933
94IKBKB0.65144911
95KDR0.64527573
96CDC70.64378842
97CDK180.64017238
98STK380.63373213
99SGK20.63329321
100PBK0.63055285
101ATR0.62939902
102WNK40.60551844
103PNCK0.59500735
104ADRBK10.58330697
105KSR10.57713251
106MAP3K60.57583145
107PLK30.57330307
108MAP3K110.56556586
109CAMK10.56189007
110LYN0.55814845
111PIM10.54899927
112EIF2AK30.54427654
113AURKA0.53528029
114CDK150.52888930
115CSNK2A20.51694275
116CDK140.50373140
117SYK0.50112720
118BCR0.49563653
119PLK10.49443755
120IRAK40.49229323
121GRK60.48627924
122PRKCE0.46936402
123PRKCQ0.46757018
124PAK60.46524066
125TXK0.46173281
126DYRK1A0.45709285
127CAMK2D0.44571949
128CDK11A0.43866229
129EIF2AK20.42974602
130PTK2B0.42857080
131CSNK2A10.42101685
132TBK10.41495763
133MAPKAPK30.41081705
134CAMKK20.40656922
135PDK20.40653011
136PHKG10.38570145
137PHKG20.38570145
138NME20.38450920
139PRKCH0.38260786
140CSNK1A10.37975434
141CAMK2G0.37858796
142PRKACA0.37773544
143MAPKAPK50.37449379
144TEC0.36711836
145DYRK20.36477723
146DAPK30.36289636
147ROCK20.31125930
148RIPK40.30835626
149RPS6KB10.29715813
150RPS6KA20.28151892
151NEK60.26752641
152RAF10.25281221

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.35966069
2Collecting duct acid secretion_Homo sapiens_hsa049663.69795616
3Nicotine addiction_Homo sapiens_hsa050333.51369532
4Parkinsons disease_Homo sapiens_hsa050123.48274277
5Synaptic vesicle cycle_Homo sapiens_hsa047213.35316620
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.85602236
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.79983865
8Alzheimers disease_Homo sapiens_hsa050102.64727446
9Protein export_Homo sapiens_hsa030602.46148713
10Vibrio cholerae infection_Homo sapiens_hsa051102.37104882
11Huntingtons disease_Homo sapiens_hsa050162.33834676
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.22732546
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.17938915
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.17512558
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.16263675
16GABAergic synapse_Homo sapiens_hsa047272.07651111
17Base excision repair_Homo sapiens_hsa034101.97996285
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.90684047
19Homologous recombination_Homo sapiens_hsa034401.90136253
20Proteasome_Homo sapiens_hsa030501.87303883
21Steroid biosynthesis_Homo sapiens_hsa001001.76279935
22RNA degradation_Homo sapiens_hsa030181.72828598
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.72470734
24Circadian entrainment_Homo sapiens_hsa047131.70895251
25Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.70237587
26Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.69891032
27Taste transduction_Homo sapiens_hsa047421.68754375
28Morphine addiction_Homo sapiens_hsa050321.66465413
29Pyruvate metabolism_Homo sapiens_hsa006201.64830154
30Amphetamine addiction_Homo sapiens_hsa050311.60342881
31Cardiac muscle contraction_Homo sapiens_hsa042601.60275799
32Fanconi anemia pathway_Homo sapiens_hsa034601.58304047
33Serotonergic synapse_Homo sapiens_hsa047261.54694465
34Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.48350054
35DNA replication_Homo sapiens_hsa030301.47373306
36Long-term potentiation_Homo sapiens_hsa047201.46873132
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.46154647
38Dopaminergic synapse_Homo sapiens_hsa047281.46028007
39Fatty acid elongation_Homo sapiens_hsa000621.42907325
40Spliceosome_Homo sapiens_hsa030401.41641933
41Glutamatergic synapse_Homo sapiens_hsa047241.38970866
42Sulfur relay system_Homo sapiens_hsa041221.35917451
43Non-homologous end-joining_Homo sapiens_hsa034501.35738754
44Primary immunodeficiency_Homo sapiens_hsa053401.33124772
45Insulin secretion_Homo sapiens_hsa049111.33084793
46Mismatch repair_Homo sapiens_hsa034301.30171374
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.29755718
48Olfactory transduction_Homo sapiens_hsa047401.27752171
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.17731962
50Cocaine addiction_Homo sapiens_hsa050301.14358764
51One carbon pool by folate_Homo sapiens_hsa006701.10357876
52Renin secretion_Homo sapiens_hsa049241.09985067
53RNA transport_Homo sapiens_hsa030131.09722077
54Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.09415184
55Selenocompound metabolism_Homo sapiens_hsa004501.04076101
56Butanoate metabolism_Homo sapiens_hsa006501.03266013
57Nucleotide excision repair_Homo sapiens_hsa034201.02598181
58Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.00755207
59Regulation of autophagy_Homo sapiens_hsa041400.89855304
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.89723974
61Propanoate metabolism_Homo sapiens_hsa006400.89681475
62Long-term depression_Homo sapiens_hsa047300.87928283
63Rheumatoid arthritis_Homo sapiens_hsa053230.84430050
64Calcium signaling pathway_Homo sapiens_hsa040200.83671652
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.82909785
66RNA polymerase_Homo sapiens_hsa030200.82564303
67Carbon metabolism_Homo sapiens_hsa012000.81710505
68Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.78753350
69Cysteine and methionine metabolism_Homo sapiens_hsa002700.77812008
70Cyanoamino acid metabolism_Homo sapiens_hsa004600.77371224
71Folate biosynthesis_Homo sapiens_hsa007900.76920286
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.75214970
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.72615194
74Fructose and mannose metabolism_Homo sapiens_hsa000510.72536205
75Salivary secretion_Homo sapiens_hsa049700.72203258
76Arginine biosynthesis_Homo sapiens_hsa002200.70582476
77Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69185179
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67891193
79Biosynthesis of amino acids_Homo sapiens_hsa012300.66547153
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65988329
81Metabolic pathways_Homo sapiens_hsa011000.64101764
82N-Glycan biosynthesis_Homo sapiens_hsa005100.63513150
83Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.62900591
84Cholinergic synapse_Homo sapiens_hsa047250.62572672
85Vitamin B6 metabolism_Homo sapiens_hsa007500.62214048
86Phenylalanine metabolism_Homo sapiens_hsa003600.60814933
87Phagosome_Homo sapiens_hsa041450.60373612
88Peroxisome_Homo sapiens_hsa041460.60096359
89Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.59990731
90Sulfur metabolism_Homo sapiens_hsa009200.59916985
91Oocyte meiosis_Homo sapiens_hsa041140.59363006
92Nitrogen metabolism_Homo sapiens_hsa009100.55878751
93Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.55745080
94Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55582240
95Caffeine metabolism_Homo sapiens_hsa002320.53153145
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.52638671
97Gastric acid secretion_Homo sapiens_hsa049710.52465707
98Glutathione metabolism_Homo sapiens_hsa004800.50233291
99Phototransduction_Homo sapiens_hsa047440.49896867
100Legionellosis_Homo sapiens_hsa051340.47996358
101Gap junction_Homo sapiens_hsa045400.47630145
102Purine metabolism_Homo sapiens_hsa002300.47582910
103Ether lipid metabolism_Homo sapiens_hsa005650.46341691
104Pyrimidine metabolism_Homo sapiens_hsa002400.45697854
105Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.45125876
106Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.44341229
107Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42847642
108Tryptophan metabolism_Homo sapiens_hsa003800.42271215
109Arachidonic acid metabolism_Homo sapiens_hsa005900.41839336
110Oxytocin signaling pathway_Homo sapiens_hsa049210.41140663
111Intestinal immune network for IgA production_Homo sapiens_hsa046720.40419717
112Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.39660446
113Type I diabetes mellitus_Homo sapiens_hsa049400.37466464
114Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37243504
115Chemical carcinogenesis_Homo sapiens_hsa052040.36852401
116Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.36631325
117Aldosterone synthesis and secretion_Homo sapiens_hsa049250.36373472
118Fat digestion and absorption_Homo sapiens_hsa049750.36144090
119Tyrosine metabolism_Homo sapiens_hsa003500.36001958
120Drug metabolism - other enzymes_Homo sapiens_hsa009830.34853952
121Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31807924
122Linoleic acid metabolism_Homo sapiens_hsa005910.31711217
123Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31323297
124Basal transcription factors_Homo sapiens_hsa030220.30433242
125cAMP signaling pathway_Homo sapiens_hsa040240.30086199
126Vascular smooth muscle contraction_Homo sapiens_hsa042700.29696215
127Epstein-Barr virus infection_Homo sapiens_hsa051690.29226811
128Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.28633067
129Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.27959653
130Ribosome_Homo sapiens_hsa030100.26137474
131Glycerophospholipid metabolism_Homo sapiens_hsa005640.26109481
132Pancreatic secretion_Homo sapiens_hsa049720.24509851
133RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.22863251
134Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.22512877
135beta-Alanine metabolism_Homo sapiens_hsa004100.21602495
136Fatty acid metabolism_Homo sapiens_hsa012120.21416891
137Primary bile acid biosynthesis_Homo sapiens_hsa001200.21211232
138Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.20823143
139alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19083782
140Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.18953116
141GnRH signaling pathway_Homo sapiens_hsa049120.18946642
142Alcoholism_Homo sapiens_hsa050340.18746466

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