NPPC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cardiac natriuretic peptides CNP-53, CNP-29 and CNP-22, which belong to the natriuretic family of peptides. The encoded peptides exhibit vasorelaxation activity in laboratory animals and elevated levels of CNP-22 have been observed in the plasma of chronic heart failure patients. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane organization (GO:0097090)7.66014021
2proline biosynthetic process (GO:0006561)7.37136716
3presynaptic membrane assembly (GO:0097105)6.59524627
4establishment of protein localization to mitochondrial membrane (GO:0090151)5.76759716
5proline metabolic process (GO:0006560)5.63334957
6transcription from mitochondrial promoter (GO:0006390)5.46749848
7embryonic process involved in female pregnancy (GO:0060136)5.23686442
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.97416620
9mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.65021557
10cilium movement (GO:0003341)4.61222263
11response to pheromone (GO:0019236)4.53209853
12epithelial cilium movement (GO:0003351)4.42645455
13positive regulation of protein homooligomerization (GO:0032464)4.36774888
14replication fork processing (GO:0031297)4.34360050
15behavioral response to nicotine (GO:0035095)4.29650163
16synaptic vesicle endocytosis (GO:0048488)4.29172966
17energy coupled proton transport, down electrochemical gradient (GO:0015985)4.28970184
18ATP synthesis coupled proton transport (GO:0015986)4.28970184
19respiratory electron transport chain (GO:0022904)4.28311027
20electron transport chain (GO:0022900)4.24605711
21epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.21170493
22regulation of respiratory gaseous exchange by neurological system process (GO:0002087)4.15750460
23synaptic vesicle exocytosis (GO:0016079)4.14549806
24axonemal dynein complex assembly (GO:0070286)4.07275268
25regulation of protein homooligomerization (GO:0032462)4.00387196
26establishment of mitochondrion localization (GO:0051654)3.99580031
27regulation of short-term neuronal synaptic plasticity (GO:0048172)3.98100363
28axoneme assembly (GO:0035082)3.95559965
29protein neddylation (GO:0045116)3.94377112
30protein-cofactor linkage (GO:0018065)3.93350792
31neuromuscular process controlling posture (GO:0050884)3.89092929
32positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.86612320
33neurofilament cytoskeleton organization (GO:0060052)3.77326474
34regulation of cAMP-dependent protein kinase activity (GO:2000479)3.76618984
35respiratory chain complex IV assembly (GO:0008535)3.76602294
36ionotropic glutamate receptor signaling pathway (GO:0035235)3.76148534
37negative regulation of synaptic transmission, GABAergic (GO:0032229)3.76132599
38negative regulation of Ras GTPase activity (GO:0034261)3.74531176
39regulation of integrin activation (GO:0033623)3.71667081
40negative regulation of JAK-STAT cascade (GO:0046426)3.71327499
41membrane assembly (GO:0071709)3.70578999
42negative regulation of heart rate (GO:0010459)3.69456182
43establishment of apical/basal cell polarity (GO:0035089)3.66848071
44protein complex biogenesis (GO:0070271)3.56338239
45negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.54625529
46nonmotile primary cilium assembly (GO:0035058)3.54505992
47negative regulation of protein oligomerization (GO:0032460)3.52674477
48neuron cell-cell adhesion (GO:0007158)3.48258172
49regulation of respiratory system process (GO:0044065)3.47857100
50positive regulation of receptor recycling (GO:0001921)3.47360653
51mitochondrial respiratory chain complex assembly (GO:0033108)3.47046455
52regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.42166906
53axon ensheathment in central nervous system (GO:0032291)3.40835501
54central nervous system myelination (GO:0022010)3.40835501
55establishment or maintenance of monopolar cell polarity (GO:0061339)3.38839855
56establishment of monopolar cell polarity (GO:0061162)3.38839855
57viral transcription (GO:0019083)3.38002200
58cellular response to ATP (GO:0071318)3.34612881
59positive regulation of synapse assembly (GO:0051965)3.33471441
60cotranslational protein targeting to membrane (GO:0006613)3.32114694
61vocalization behavior (GO:0071625)3.31957796
62positive regulation of developmental pigmentation (GO:0048087)3.31379833
63asymmetric protein localization (GO:0008105)3.29913894
64translational termination (GO:0006415)3.29290415
65oxidative demethylation (GO:0070989)3.27970567
66glutamate receptor signaling pathway (GO:0007215)3.25448097
67SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.25070879
68synaptic transmission, glutamatergic (GO:0035249)3.22872332
69positive regulation of circadian rhythm (GO:0042753)3.21286313
70regulation of mitochondrial translation (GO:0070129)3.20369528
71mitochondrial respiratory chain complex I assembly (GO:0032981)3.19241764
72NADH dehydrogenase complex assembly (GO:0010257)3.19241764
73mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.19241764
74glial cell migration (GO:0008347)3.18443627
75maturation of SSU-rRNA (GO:0030490)3.15092195
76protein targeting to ER (GO:0045047)3.14840635
77negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.13156410
78signal complex assembly (GO:0007172)3.10830258
79mitochondrion transport along microtubule (GO:0047497)3.09706725
80establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.09706725
81negative regulation of response to food (GO:0032096)3.09503823
82negative regulation of appetite (GO:0032099)3.09503823
83transmission of nerve impulse (GO:0019226)3.07437787
84ventricular system development (GO:0021591)3.05743780
85auditory receptor cell stereocilium organization (GO:0060088)3.05523517
86neuron-neuron synaptic transmission (GO:0007270)3.05132505
87gamma-aminobutyric acid signaling pathway (GO:0007214)3.04811194
88ribosomal small subunit biogenesis (GO:0042274)3.03272688
89regulation of collateral sprouting (GO:0048670)3.02967566
90cytochrome complex assembly (GO:0017004)3.01783244
91thalamus development (GO:0021794)3.01771431
92establishment of protein localization to endoplasmic reticulum (GO:0072599)3.01290725
93glutamate secretion (GO:0014047)3.00355395
94regulation of membrane depolarization (GO:0003254)3.00284420
95inner ear receptor stereocilium organization (GO:0060122)2.98720886
96striatum development (GO:0021756)2.97799402
97retinal ganglion cell axon guidance (GO:0031290)2.97384784
98positive regulation of synaptic transmission, GABAergic (GO:0032230)2.96140956
99maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.95672820
100G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.95472553
101dopamine transport (GO:0015872)2.95092126
102regulation of excitatory postsynaptic membrane potential (GO:0060079)2.93918459
103gamma-aminobutyric acid transport (GO:0015812)2.91710869
104protein localization to synapse (GO:0035418)2.91564519
105hydrogen ion transmembrane transport (GO:1902600)2.91560970
106protein localization to endoplasmic reticulum (GO:0070972)2.90694842
107DNA integration (GO:0015074)2.90282472
108regulation of glutamate receptor signaling pathway (GO:1900449)2.89996357
109negative regulation of neurotransmitter transport (GO:0051589)2.89546088
110postsynaptic membrane organization (GO:0001941)2.88424247
111cerebellar granule cell differentiation (GO:0021707)2.88053095
112maturation of 5.8S rRNA (GO:0000460)2.87658237
113positive regulation of dendritic spine morphogenesis (GO:0061003)2.87576668
114regulation of neuronal synaptic plasticity (GO:0048168)2.87452961
115regulation of transmission of nerve impulse (GO:0051969)2.87368121
116anterograde axon cargo transport (GO:0008089)2.87334262
117positive regulation of glomerulus development (GO:0090193)2.86733806
1184-hydroxyproline metabolic process (GO:0019471)2.86448051
119regulation of respiratory gaseous exchange (GO:0043576)2.86179906
120negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.86108510
121positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.84986379
122pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.84347106
123embryonic camera-type eye development (GO:0031076)2.83668649
124regulation of mitochondrial depolarization (GO:0051900)2.83319493
125mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.82534347
126peptidyl-proline hydroxylation (GO:0019511)2.82479478
127glycosphingolipid biosynthetic process (GO:0006688)2.82117609
128transcription elongation from RNA polymerase III promoter (GO:0006385)2.81392837
129termination of RNA polymerase III transcription (GO:0006386)2.81392837
130regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.81149834
131neuronal action potential propagation (GO:0019227)2.80780658
132retina layer formation (GO:0010842)2.79275970
133short-term memory (GO:0007614)2.79265208
134proton transport (GO:0015992)2.78610950
135positive regulation of TOR signaling (GO:0032008)2.78526866
136regulation of hexokinase activity (GO:1903299)2.77588938
137regulation of glucokinase activity (GO:0033131)2.77588938
138negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.77383808
139positive regulation of microtubule polymerization (GO:0031116)2.76492402
140cell migration in hindbrain (GO:0021535)2.75673629
141negative regulation of neurotransmitter secretion (GO:0046929)2.75117722
142regulation of cilium movement (GO:0003352)2.74626113
143positive regulation of p38MAPK cascade (GO:1900745)2.73500476
144regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.71702641
145glutamine family amino acid biosynthetic process (GO:0009084)2.70003368
146hydrogen transport (GO:0006818)2.69603292
147convergent extension (GO:0060026)2.69424483
148cellular response to zinc ion (GO:0071294)2.68550300
149ATP biosynthetic process (GO:0006754)2.68385823
150regulation of long-term neuronal synaptic plasticity (GO:0048169)2.68222282
151regulation of postsynaptic membrane potential (GO:0060078)2.67746945
152cullin deneddylation (GO:0010388)2.67500743
153regulation of sensory perception of pain (GO:0051930)2.67176574
154regulation of sensory perception (GO:0051931)2.67176574
155limb bud formation (GO:0060174)2.65607388
156head development (GO:0060322)2.65205862
157platelet dense granule organization (GO:0060155)2.64848191
158positive regulation of action potential (GO:0045760)2.64571477
159intracellular protein transmembrane import (GO:0044743)2.63837923
160dorsal/ventral neural tube patterning (GO:0021904)2.62780426
161translational elongation (GO:0006414)2.62561460
162neuromuscular process (GO:0050905)2.62349164
163neuron recognition (GO:0008038)2.61430350
164proteasome assembly (GO:0043248)2.59062352
165regulation of mesenchymal cell apoptotic process (GO:2001053)2.57547474
166positive regulation of potassium ion transmembrane transport (GO:1901381)2.56585299
167rhodopsin mediated signaling pathway (GO:0016056)2.56400808
168cellular protein complex disassembly (GO:0043624)2.56173802
169hindbrain development (GO:0030902)2.54895885
170terpenoid biosynthetic process (GO:0016114)2.54763907
171embryonic skeletal joint morphogenesis (GO:0060272)2.54304784
172regulation of microtubule-based movement (GO:0060632)2.52892740
173protein hydroxylation (GO:0018126)2.50706393
174midbrain development (GO:0030901)2.50279034
175pseudouridine synthesis (GO:0001522)2.48570598
176protein localization to cilium (GO:0061512)2.48473453
177peptidyl-histidine modification (GO:0018202)2.46622964
178purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.45564596
179protein heterotetramerization (GO:0051290)2.44519646
180positive regulation of mitochondrial fission (GO:0090141)2.44125432
181somite development (GO:0061053)2.41836066
182positive regulation of urine volume (GO:0035810)2.41788917
183pyrimidine nucleoside salvage (GO:0043097)2.40975656
184pyrimidine-containing compound salvage (GO:0008655)2.40975656
185chaperone-mediated protein transport (GO:0072321)2.40961589
186response to redox state (GO:0051775)2.40815647
187serotonin metabolic process (GO:0042428)2.40309634
188protein deneddylation (GO:0000338)2.40030410

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.97557978
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.08107424
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.04054471
4GBX2_23144817_ChIP-Seq_PC3_Human2.92096676
5ERG_21242973_ChIP-ChIP_JURKAT_Human2.72486964
6ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.53032875
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.43762834
8KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.43762834
9KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.43762834
10CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.40897585
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.39152263
12ZNF274_21170338_ChIP-Seq_K562_Hela2.38742833
13* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.36780829
14* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.28958158
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.26133229
16CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.24990467
17AR_21572438_ChIP-Seq_LNCaP_Human2.19317575
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.12686849
19EWS_26573619_Chip-Seq_HEK293_Human2.12685419
20JARID2_20064375_ChIP-Seq_MESCs_Mouse2.11614815
21REST_21632747_ChIP-Seq_MESCs_Mouse2.09766697
22EZH2_27304074_Chip-Seq_ESCs_Mouse2.07728522
23* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.06783071
24EST1_17652178_ChIP-ChIP_JURKAT_Human2.05631930
25SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.04942456
26EZH2_18974828_ChIP-Seq_MESCs_Mouse2.02042757
27RNF2_18974828_ChIP-Seq_MESCs_Mouse2.02042757
28BMI1_23680149_ChIP-Seq_NPCS_Mouse1.96796452
29* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.96367119
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.90817924
31VDR_22108803_ChIP-Seq_LS180_Human1.87534032
32* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.87448753
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.86929226
34* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.86542895
35NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.86085880
36EED_16625203_ChIP-ChIP_MESCs_Mouse1.81758419
37* RNF2_27304074_Chip-Seq_ESCs_Mouse1.80297449
38RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.79717695
39RNF2_27304074_Chip-Seq_NSC_Mouse1.79606302
40SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.79110035
41CREB1_15753290_ChIP-ChIP_HEK293T_Human1.77998850
42GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.77502201
43NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.72952509
44* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.72897953
45REST_18959480_ChIP-ChIP_MESCs_Mouse1.72582051
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.71448876
47CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.68486845
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68196712
49CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.67875442
50* RING1B_27294783_Chip-Seq_NPCs_Mouse1.66982146
51NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.66076560
52EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64555834
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61309492
54* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.59258341
55STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.55761817
56POU5F1_16518401_ChIP-PET_MESCs_Mouse1.54306863
57SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.54007055
58MYC_18940864_ChIP-ChIP_HL60_Human1.52047440
59ETS1_20019798_ChIP-Seq_JURKAT_Human1.51116564
60SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.50222289
61RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.49573988
62MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49257522
63POU5F1_16153702_ChIP-ChIP_HESCs_Human1.48916576
64RARB_27405468_Chip-Seq_BRAIN_Mouse1.44776309
65TP53_20018659_ChIP-ChIP_R1E_Mouse1.43685066
66ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.42773155
67* EZH2_27294783_Chip-Seq_ESCs_Mouse1.40899483
68JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.40785414
69PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.40065442
70CBX2_27304074_Chip-Seq_ESCs_Mouse1.38003509
71HIF1A_21447827_ChIP-Seq_MCF-7_Human1.37153150
72RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.35740082
73EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.35653384
74P53_22127205_ChIP-Seq_FIBROBLAST_Human1.35034925
75PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.34871547
76ZFP57_27257070_Chip-Seq_ESCs_Mouse1.34640591
77POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.33212347
78* RING1B_27294783_Chip-Seq_ESCs_Mouse1.33133117
79MYC_18555785_ChIP-Seq_MESCs_Mouse1.31599788
80DROSHA_22980978_ChIP-Seq_HELA_Human1.28421860
81NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.26242712
82FUS_26573619_Chip-Seq_HEK293_Human1.23537469
83ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.20940274
84TP53_22573176_ChIP-Seq_HFKS_Human1.20094449
85PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.19737422
86NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.19686416
87GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19647908
88TCF3_18692474_ChIP-Seq_MESCs_Mouse1.19062198
89UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16379422
90ELK1_19687146_ChIP-ChIP_HELA_Human1.14761288
91TP53_18474530_ChIP-ChIP_U2OS_Human1.14651411
92P300_19829295_ChIP-Seq_ESCs_Human1.14073680
93PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.13020540
94AR_25329375_ChIP-Seq_VCAP_Human1.11029892
95SMAD3_21741376_ChIP-Seq_EPCs_Human1.10856460
96SMAD4_21799915_ChIP-Seq_A2780_Human1.08854434
97ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06972737
98FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.06244165
99BCAT_22108803_ChIP-Seq_LS180_Human1.06210067
100ER_23166858_ChIP-Seq_MCF-7_Human1.05805316
101XRN2_22483619_ChIP-Seq_HELA_Human1.04027435
102MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03995912
103TAF15_26573619_Chip-Seq_HEK293_Human1.03427826
104NCOR_22424771_ChIP-Seq_293T_Human1.03271767
105ZFP281_27345836_Chip-Seq_ESCs_Mouse1.03232500
106ZFP281_18757296_ChIP-ChIP_E14_Mouse1.02578867
107IRF1_19129219_ChIP-ChIP_H3396_Human1.01603432
108TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01423857
109CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99660285
110SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99152452
111SOX2_16153702_ChIP-ChIP_HESCs_Human0.99148191
112SRF_21415370_ChIP-Seq_HL-1_Mouse0.98457082
113RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.98268885
114TP53_16413492_ChIP-PET_HCT116_Human0.97634157
115DCP1A_22483619_ChIP-Seq_HELA_Human0.96685955
116CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96633857
117* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.95259523
118RBPJ_22232070_ChIP-Seq_NCS_Mouse0.95010431
119* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.93475241
120* TTF2_22483619_ChIP-Seq_HELA_Human0.93142250
121DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92782964
122RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.91346099
123TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90868190
124POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90868190
125NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90365875
126KLF5_20875108_ChIP-Seq_MESCs_Mouse0.89835183
127SALL1_21062744_ChIP-ChIP_HESCs_Human0.89665990
128SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.89353554
129IKZF1_21737484_ChIP-ChIP_HCT116_Human0.89315887
130OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89258658
131TET1_21490601_ChIP-Seq_MESCs_Mouse0.88988830
132TRIM28_21343339_ChIP-Seq_HEK293_Human0.88977599
133LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88727890
134TAL1_26923725_Chip-Seq_HPCs_Mouse0.88311733
135KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.88046673
136FOXA1_21572438_ChIP-Seq_LNCaP_Human0.87991017
137TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.86795527
138* SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.86785845
139TBL1_22424771_ChIP-Seq_293T_Human0.86730500
140PIAS1_25552417_ChIP-Seq_VCAP_Human0.86154859
141CTCF_27219007_Chip-Seq_Bcells_Human0.85367493
142TOP2B_26459242_ChIP-Seq_MCF-7_Human0.84961700
143TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.84819629
144NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.81912344
145NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.81775455
146SOX9_26525672_Chip-Seq_HEART_Mouse0.81603799
147TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81094232
148ARNT_22903824_ChIP-Seq_MCF-7_Human0.80910452
149CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.80771013
150GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.80513337
151PU.1_20513432_ChIP-Seq_Bcells_Mouse0.80457695
152YAP1_20516196_ChIP-Seq_MESCs_Mouse0.79946648

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation6.43233070
2MP0004859_abnormal_synaptic_plasticity3.58616735
3MP0002102_abnormal_ear_morphology3.43805091
4MP0003880_abnormal_central_pattern3.36012729
5MP0002638_abnormal_pupillary_reflex3.34877371
6MP0009046_muscle_twitch3.24835769
7MP0002064_seizures2.78876687
8MP0009379_abnormal_foot_pigmentation2.73824836
9* MP0003635_abnormal_synaptic_transmissio2.69946311
10MP0009278_abnormal_bone_marrow2.57799365
11MP0002063_abnormal_learning/memory/cond2.52504172
12MP0001984_abnormal_olfaction2.50917120
13MP0002572_abnormal_emotion/affect_behav2.49987737
14MP0009745_abnormal_behavioral_response2.43957779
15MP0008057_abnormal_DNA_replication2.43690449
16MP0008995_early_reproductive_senescence2.40972851
17MP0003195_calcinosis2.19759334
18MP0002272_abnormal_nervous_system2.17711446
19MP0004742_abnormal_vestibular_system2.13753502
20MP0004142_abnormal_muscle_tone2.07086810
21MP0004233_abnormal_muscle_weight2.05742435
22MP0002653_abnormal_ependyma_morphology1.93473448
23MP0003136_yellow_coat_color1.91739165
24MP0010030_abnormal_orbit_morphology1.90525162
25MP0003283_abnormal_digestive_organ1.89163507
26MP0001970_abnormal_pain_threshold1.87727440
27MP0001968_abnormal_touch/_nociception1.85514641
28MP0004133_heterotaxia1.83867433
29MP0001440_abnormal_grooming_behavior1.80465987
30MP0000778_abnormal_nervous_system1.79958362
31MP0002733_abnormal_thermal_nociception1.79573128
32MP0005084_abnormal_gallbladder_morpholo1.79117385
33MP0002277_abnormal_respiratory_mucosa1.77406565
34MP0004270_analgesia1.76796730
35MP0002249_abnormal_larynx_morphology1.75889119
36MP0002282_abnormal_trachea_morphology1.66525396
37MP0006072_abnormal_retinal_apoptosis1.64677994
38MP0002067_abnormal_sensory_capabilities1.64480129
39MP0001501_abnormal_sleep_pattern1.63907737
40MP0010386_abnormal_urinary_bladder1.60705945
41MP0002009_preneoplasia1.59012730
42MP0002736_abnormal_nociception_after1.58188962
43MP0000955_abnormal_spinal_cord1.49989395
44MP0004134_abnormal_chest_morphology1.47747473
45MP0006035_abnormal_mitochondrial_morpho1.47643873
46MP0001486_abnormal_startle_reflex1.46558115
47MP0003890_abnormal_embryonic-extraembry1.46548133
48MP0006292_abnormal_olfactory_placode1.46188165
49MP0000462_abnormal_digestive_system1.44372137
50MP0002735_abnormal_chemical_nociception1.43745942
51MP0003011_delayed_dark_adaptation1.42275057
52MP0005423_abnormal_somatic_nervous1.40632227
53MP0002734_abnormal_mechanical_nocicepti1.39279158
54MP0003119_abnormal_digestive_system1.38203516
55MP0000639_abnormal_adrenal_gland1.35382959
56MP0000566_synostosis1.34102612
57MP0000015_abnormal_ear_pigmentation1.33609923
58MP0003122_maternal_imprinting1.31674035
59MP0008877_abnormal_DNA_methylation1.31462386
60MP0002234_abnormal_pharynx_morphology1.30265039
61MP0004924_abnormal_behavior1.30154564
62MP0005386_behavior/neurological_phenoty1.30154564
63MP0005248_abnormal_Harderian_gland1.28782806
64MP0001529_abnormal_vocalization1.27895216
65MP0005646_abnormal_pituitary_gland1.26278121
66MP0003329_amyloid_beta_deposits1.26175011
67MP0002066_abnormal_motor_capabilities/c1.24760944
68MP0001905_abnormal_dopamine_level1.22615092
69MP0001188_hyperpigmentation1.21020298
70MP0001340_abnormal_eyelid_morphology1.20655099
71MP0000579_abnormal_nail_morphology1.20578808
72MP0002233_abnormal_nose_morphology1.19873568
73MP0003123_paternal_imprinting1.19749661
74MP0003634_abnormal_glial_cell1.19662295
75MP0003633_abnormal_nervous_system1.19507661
76MP0003121_genomic_imprinting1.19021070
77MP0008058_abnormal_DNA_repair1.15689129
78MP0005645_abnormal_hypothalamus_physiol1.13827436
79MP0005253_abnormal_eye_physiology1.12652903
80* MP0002882_abnormal_neuron_morphology1.09552932
81MP0004043_abnormal_pH_regulation1.09321966
82MP0003221_abnormal_cardiomyocyte_apopto1.09223344
83MP0000470_abnormal_stomach_morphology1.06913020
84MP0005083_abnormal_biliary_tract1.05540418
85MP0002557_abnormal_social/conspecific_i1.05253791
86MP0008569_lethality_at_weaning1.04650130
87MP0001764_abnormal_homeostasis1.04516900
88MP0001502_abnormal_circadian_rhythm1.04463204
89MP0001286_abnormal_eye_development1.03318201
90MP0003385_abnormal_body_wall1.01912814
91MP0003937_abnormal_limbs/digits/tail_de1.01383472
92MP0000762_abnormal_tongue_morphology1.01169688
93MP0009250_abnormal_appendicular_skeleto1.00894532
94MP0001270_distended_abdomen1.00413501
95MP0002152_abnormal_brain_morphology1.00251886
96* MP0002184_abnormal_innervation0.99472251
97MP0003631_nervous_system_phenotype0.98611825
98MP0000631_abnormal_neuroendocrine_gland0.98423606
99MP0001986_abnormal_taste_sensitivity0.98251239
100MP0002163_abnormal_gland_morphology0.97024707
101MP0000751_myopathy0.96128618
102MP0004085_abnormal_heartbeat0.96041935
103* MP0004811_abnormal_neuron_physiology0.94859430
104MP0003646_muscle_fatigue0.94201104
105MP0001485_abnormal_pinna_reflex0.93821595
106MP0005623_abnormal_meninges_morphology0.93135066
107MP0008004_abnormal_stomach_pH0.92315521
108MP0008875_abnormal_xenobiotic_pharmacok0.89586965
109MP0003938_abnormal_ear_development0.87912004
110MP0000920_abnormal_myelination0.86983238
111MP0003942_abnormal_urinary_system0.86286830
112MP0003303_peritoneal_inflammation0.85605644
113MP0006276_abnormal_autonomic_nervous0.84720686
114MP0003755_abnormal_palate_morphology0.84610736
115MP0005410_abnormal_fertilization0.84444926
116MP0005620_abnormal_muscle_contractility0.84339427
117MP0004885_abnormal_endolymph0.83365247
118MP0000681_abnormal_thyroid_gland0.83331230
119MP0000049_abnormal_middle_ear0.81292725
120MP0002332_abnormal_exercise_endurance0.81095077
121MP0005195_abnormal_posterior_eye0.81006279
122MP0002139_abnormal_hepatobiliary_system0.80425284
123MP0005085_abnormal_gallbladder_physiolo0.80361285
124MP0002108_abnormal_muscle_morphology0.79620476
125* MP0002752_abnormal_somatic_nervous0.78208289
126MP0006082_CNS_inflammation0.76986785
127MP0001293_anophthalmia0.76925121
128MP0003786_premature_aging0.76567199
129MP0000026_abnormal_inner_ear0.76131830
130MP0002928_abnormal_bile_duct0.76055435
131MP0001963_abnormal_hearing_physiology0.75265178
132MP0005391_vision/eye_phenotype0.73790375
133MP0004215_abnormal_myocardial_fiber0.73202348
134MP0008872_abnormal_physiological_respon0.73175253
135MP0002972_abnormal_cardiac_muscle0.72418848
136MP0002932_abnormal_joint_morphology0.71204186
137MP0005058_abnormal_lysosome_morphology0.71113337
138MP0001943_abnormal_respiration0.70635212
139MP0003137_abnormal_impulse_conducting0.70533037
140MP0002938_white_spotting0.69773224
141MP0000534_abnormal_ureter_morphology0.69210869
142MP0005551_abnormal_eye_electrophysiolog0.68602377
143MP0002751_abnormal_autonomic_nervous0.68082864

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.78732601
2Annular pancreas (HP:0001734)4.35645239
3Focal motor seizures (HP:0011153)4.33335466
4Acute necrotizing encephalopathy (HP:0006965)4.19209864
5Abnormal respiratory epithelium morphology (HP:0012253)4.17598317
6Abnormal respiratory motile cilium morphology (HP:0005938)4.17598317
7Mitochondrial inheritance (HP:0001427)3.89657267
8Abnormal mitochondria in muscle tissue (HP:0008316)3.84967392
9Concave nail (HP:0001598)3.83338614
10Atonic seizures (HP:0010819)3.83295620
11Increased IgM level (HP:0003496)3.82158031
12Increased hepatocellular lipid droplets (HP:0006565)3.80891697
13Abnormal respiratory motile cilium physiology (HP:0012261)3.71028975
14Hepatocellular necrosis (HP:0001404)3.66260536
15Epileptic encephalopathy (HP:0200134)3.48404346
16Increased CSF lactate (HP:0002490)3.47920103
17Acute encephalopathy (HP:0006846)3.47609260
18Myokymia (HP:0002411)3.44837267
19Coronal craniosynostosis (HP:0004440)3.41852272
20Abnormal ciliary motility (HP:0012262)3.38752245
21Progressive macrocephaly (HP:0004481)3.38449008
223-Methylglutaconic aciduria (HP:0003535)3.36223067
23Turricephaly (HP:0000262)3.27169332
24Rhinitis (HP:0012384)3.23551315
25Hepatic necrosis (HP:0002605)3.20891667
26Rectal fistula (HP:0100590)3.16906083
27Rectovaginal fistula (HP:0000143)3.16906083
28Lipid accumulation in hepatocytes (HP:0006561)3.13694248
29Alacrima (HP:0000522)3.13078151
30Congenital stationary night blindness (HP:0007642)3.12095539
31Narrow nasal bridge (HP:0000446)3.10925722
32Absent/shortened dynein arms (HP:0200106)3.06381607
33Dynein arm defect of respiratory motile cilia (HP:0012255)3.06381607
34Febrile seizures (HP:0002373)3.05680352
35Clumsiness (HP:0002312)3.05215650
36Gait imbalance (HP:0002141)3.05037043
37Molar tooth sign on MRI (HP:0002419)3.00118355
38Abnormality of midbrain morphology (HP:0002418)3.00118355
39Tented upper lip vermilion (HP:0010804)2.98970378
40Action tremor (HP:0002345)2.98701947
41Rib fusion (HP:0000902)2.95826604
42Progressive cerebellar ataxia (HP:0002073)2.92231543
43Birth length less than 3rd percentile (HP:0003561)2.88375492
44Male infertility (HP:0003251)2.85511618
45Renal Fanconi syndrome (HP:0001994)2.81276396
46Congenital primary aphakia (HP:0007707)2.79962039
47Abnormal pancreas size (HP:0012094)2.77120056
48Abnormality of the labia minora (HP:0012880)2.71807658
49Anteriorly placed anus (HP:0001545)2.71584412
50True hermaphroditism (HP:0010459)2.70398180
51Medial flaring of the eyebrow (HP:0010747)2.65519208
52Intestinal fistula (HP:0100819)2.63319078
53Facial hemangioma (HP:0000329)2.60957117
54Thickened helices (HP:0000391)2.59792293
55Abnormality of male internal genitalia (HP:0000022)2.59472401
56Pheochromocytoma (HP:0002666)2.58360600
57Vaginal fistula (HP:0004320)2.56956379
58Increased intramyocellular lipid droplets (HP:0012240)2.56390394
59Vaginal atresia (HP:0000148)2.54911654
60Absence seizures (HP:0002121)2.51435212
61Focal seizures (HP:0007359)2.50758471
62Exertional dyspnea (HP:0002875)2.50422137
63Abnormality of alanine metabolism (HP:0010916)2.50056278
64Hyperalaninemia (HP:0003348)2.50056278
65Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.50056278
66Generalized tonic-clonic seizures (HP:0002069)2.48434963
67Genital tract atresia (HP:0001827)2.48415153
68Alopecia of scalp (HP:0002293)2.47122757
69Dialeptic seizures (HP:0011146)2.43815322
70Hyperventilation (HP:0002883)2.43810441
71Cerebral edema (HP:0002181)2.43422278
72Fetal akinesia sequence (HP:0001989)2.42459747
73Hamartoma (HP:0010566)2.39471487
74Nephrogenic diabetes insipidus (HP:0009806)2.38612915
75Retinal dysplasia (HP:0007973)2.36664337
76Abnormality of urine glucose concentration (HP:0011016)2.33000405
77Glycosuria (HP:0003076)2.33000405
78Aplasia of the musculature (HP:0100854)2.32702724
79Pendular nystagmus (HP:0012043)2.32422585
80Amelogenesis imperfecta (HP:0000705)2.29970975
81Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.28916397
82Neuroendocrine neoplasm (HP:0100634)2.26890784
83Decreased lacrimation (HP:0000633)2.26194114
84Aplasia/hypoplasia of the uterus (HP:0008684)2.25347345
85Short humerus (HP:0005792)2.24070753
86Reticulocytopenia (HP:0001896)2.24036082
87Decreased activity of mitochondrial respiratory chain (HP:0008972)2.23987436
88Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.23987436
89Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.23507879
90Degeneration of the lateral corticospinal tracts (HP:0002314)2.23507879
91Septo-optic dysplasia (HP:0100842)2.23062425
92Hypoplasia of the uterus (HP:0000013)2.19742433
93Tongue fasciculations (HP:0001308)2.19562683
94Bulbar palsy (HP:0001283)2.19163917
95Optic disc pallor (HP:0000543)2.18027897
96Respiratory difficulties (HP:0002880)2.17956592
97Median cleft lip (HP:0000161)2.16683233
98Dysautonomia (HP:0002459)2.16161022
99Limb dystonia (HP:0002451)2.16080208
100Specific learning disability (HP:0001328)2.15938475
101Hypothermia (HP:0002045)2.15831762
102Anterior segment dysgenesis (HP:0007700)2.15803737
103Abnormality of renal resorption (HP:0011038)2.14536259
104Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.12448048
105Abnormal number of erythroid precursors (HP:0012131)2.11805691
106Polyphagia (HP:0002591)2.11515809
107Pancreatic cysts (HP:0001737)2.11072474
108Congenital glaucoma (HP:0001087)2.09749529
109Retinal atrophy (HP:0001105)2.09270672
110Infertility (HP:0000789)2.09009424
111Pustule (HP:0200039)2.08599317
112Ectopic anus (HP:0004397)2.08450140
113Absent speech (HP:0001344)2.08299220
114Macrocytic anemia (HP:0001972)2.07846254
115Hypoplasia of the ulna (HP:0003022)2.07757502
116Exercise intolerance (HP:0003546)2.07487055
117Respiratory failure (HP:0002878)2.06896659
118Increased serum lactate (HP:0002151)2.04309354
119Occipital encephalocele (HP:0002085)2.03665025
120Ulnar bowing (HP:0003031)2.03197451
121Lactic acidosis (HP:0003128)2.02759370
122Poor coordination (HP:0002370)2.02735527
123Aplasia/hypoplasia of the humerus (HP:0006507)2.02427833
124Scanning speech (HP:0002168)2.01458584
125Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.99592751
126Abnormal number of incisors (HP:0011064)1.99425831
127Broad-based gait (HP:0002136)1.99252459
128Pancreatic fibrosis (HP:0100732)1.98887370
129Optic nerve hypoplasia (HP:0000609)1.98040406
130Abnormality of the corticospinal tract (HP:0002492)1.97962528
131Orthostatic hypotension (HP:0001278)1.97731151
132Broad alveolar ridges (HP:0000187)1.95528041
133Abnormality of cells of the erythroid lineage (HP:0012130)1.93396050
134Renal dysplasia (HP:0000110)1.93344158
135Nephronophthisis (HP:0000090)1.92836762
136Microretrognathia (HP:0000308)1.92021387
137Short chin (HP:0000331)1.91960927
138Leukodystrophy (HP:0002415)1.90884495
139Chronic bronchitis (HP:0004469)1.90634095
140Muscle fiber splitting (HP:0003555)1.88858327
141Increased muscle lipid content (HP:0009058)1.88486364
142Hyperphosphaturia (HP:0003109)1.87984190
143Abnormality of the anterior horn cell (HP:0006802)1.87792423
144Degeneration of anterior horn cells (HP:0002398)1.87792423
145Diminished movement (HP:0002374)1.87516711
146Congenital hip dislocation (HP:0001374)1.87432379
147Diaphragmatic weakness (HP:0009113)1.86978956
148Muscle fibrillation (HP:0010546)1.86600818
149Inability to walk (HP:0002540)1.86589444
150Type II lissencephaly (HP:0007260)1.85904296
151Sleep apnea (HP:0010535)1.85618482
152Sclerocornea (HP:0000647)1.84745289
153Visual hallucinations (HP:0002367)1.84345343
154Hypotelorism (HP:0000601)1.82669669
155Abnormal eating behavior (HP:0100738)1.82656237
156Increased number of teeth (HP:0011069)1.82587900
157Intestinal atresia (HP:0011100)1.82054157
158Ankle clonus (HP:0011448)1.81389329
159Shawl scrotum (HP:0000049)1.81311837
160Long foot (HP:0001833)1.80862334
161CNS demyelination (HP:0007305)1.80041394
162Poor suck (HP:0002033)1.79687219
163Anophthalmia (HP:0000528)1.78657947
164Abnormal hemoglobin (HP:0011902)1.78504216
165Hypochromic microcytic anemia (HP:0004840)1.77488556
166Abnormal urine phosphate concentration (HP:0012599)1.77463752
167Synostosis involving the elbow (HP:0003938)1.76670467
168Humeroradial synostosis (HP:0003041)1.76670467
169Premature skin wrinkling (HP:0100678)1.76561728
170Supernumerary spleens (HP:0009799)1.74146747

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK156.29514258
2ICK4.12708187
3DDR23.77246704
4CASK3.22285101
5FGR3.01425026
6BMPR1B2.98052850
7MAP3K62.80905914
8BUB12.75752694
9PINK12.70315435
10UHMK12.60620967
11PNCK2.46355042
12EPHB22.37223735
13DAPK12.24988790
14PRPF4B2.16892759
15TYRO32.16574476
16AKT32.10223924
17STK162.07661252
18MAP3K111.91769139
19WEE11.87761084
20WNK31.87382448
21WNK41.73668381
22BMX1.70504308
23MATK1.61927724
24EPHA41.58736624
25YES11.57896655
26MAP3K91.57744006
27PIM21.56924874
28NEK11.56733798
29PDK21.56114943
30STK38L1.55795214
31TAOK31.55197265
32BRAF1.39006126
33CAMK2B1.38017137
34GRK11.36698562
35TNIK1.35773549
36OXSR11.34624398
37VRK21.34212510
38TGFBR11.33062815
39NTRK31.31557302
40PRKD21.29110159
41DYRK31.28999096
42STK391.23952266
43CDK191.21310247
44CSK1.20103113
45BRSK21.11735106
46PHKG11.11564437
47PHKG21.11564437
48CAMK2G1.09698570
49MARK11.08366897
50CSNK1G11.06767277
51TRIM281.04635065
52TAOK21.04245351
53CAMK2A1.03286401
54TAF11.02369570
55CSNK1G31.01980142
56DAPK20.99890425
57GSK3A0.99778076
58NTRK20.99439037
59KSR10.98945055
60MAP3K120.97017965
61PAK60.96999140
62MST40.96649923
63PLK20.96381574
64TRPM70.96065417
65CAMK2D0.94889168
66MAP2K40.94183919
67BRSK10.91721278
68DYRK1B0.88829665
69FES0.88321485
70CSNK1A1L0.87049194
71VRK10.85286468
72ADRBK20.82653218
73CSNK1G20.82561297
74ARAF0.82288494
75CDC42BPA0.81907307
76LATS20.81014434
77PBK0.80698376
78MAP2K70.78257145
79SRPK10.76961403
80MAP3K40.76373202
81RPS6KC10.75536136
82RPS6KL10.75536136
83PDGFRA0.74462795
84MINK10.74292695
85MOS0.74204752
86EIF2AK30.73973886
87PRKCG0.73855733
88SIK30.73732735
89CDK50.72994646
90MAP4K20.68486469
91RPS6KA50.63278359
92PLK10.61994860
93AURKA0.60723245
94BCKDK0.60338753
95TSSK60.59738836
96RPS6KA60.59019025
97PRKCI0.57905171
98PLK30.57628057
99DYRK20.55527273
100PIK3CA0.54747380
101BCR0.54728990
102STK240.54528691
103CDK180.54500180
104TLK10.53336569
105GRK50.52673895
106NTRK10.52551678
107CDK140.52442645
108CDK150.52099064
109SGK10.51509117
110ERBB30.50024073
111PRKCQ0.49017731
112ADRBK10.48825524
113PRKG10.46413722
114CDK11A0.45206580
115MAP3K100.44755716
116INSRR0.44342362
117CDK70.44103654
118MARK20.43841857
119ROCK20.42823868
120PTK2B0.42764274
121PRKCE0.41980403
122CSNK2A10.41677868
123MYLK0.41610263
124PIM10.41116608
125ILK0.40701065
126PASK0.40352384
127SGK2230.39177985
128SGK4940.39177985
129ERBB40.39018272
130PAK30.38875352
131IRAK20.38447910
132DAPK30.38149594
133MKNK20.37940562
134CHEK20.37744550
135SIK20.37038793
136FER0.35877934
137MAPKAPK50.35253164
138MAP3K50.32485975
139CSNK1A10.32389287
140CSNK2A20.31058374
141MKNK10.30851216
142WNK10.30619022
143HIPK20.30570386
144RPS6KB10.30314073
145MAPK40.29947365
146RAF10.29293492
147PRKCZ0.27736408
148NME10.27246523
149EGFR0.26859919
150PKN10.26571964
151MAPK100.25632588
152PRKACA0.25607414
153RPS6KA30.24777066
154MAPK130.24447387
155CDK80.24434579
156PRKAA10.23221606
157RPS6KA10.23191177
158CSNK1E0.23016575

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.92268144
2Fatty acid biosynthesis_Homo sapiens_hsa000613.77999521
3Ribosome_Homo sapiens_hsa030103.74518815
4Nitrogen metabolism_Homo sapiens_hsa009103.60004343
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.54678598
6Collecting duct acid secretion_Homo sapiens_hsa049663.25291639
7Protein export_Homo sapiens_hsa030603.08297560
8Synaptic vesicle cycle_Homo sapiens_hsa047213.02522765
9Oxidative phosphorylation_Homo sapiens_hsa001902.48033824
10GABAergic synapse_Homo sapiens_hsa047272.30308882
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.20381491
12RNA polymerase_Homo sapiens_hsa030202.07704831
13Amphetamine addiction_Homo sapiens_hsa050311.94660109
14Long-term depression_Homo sapiens_hsa047301.91857979
15Glutamatergic synapse_Homo sapiens_hsa047241.82013186
16Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.81808239
17Basal transcription factors_Homo sapiens_hsa030221.79539568
18Fatty acid elongation_Homo sapiens_hsa000621.77664588
19Circadian rhythm_Homo sapiens_hsa047101.73422370
20Circadian entrainment_Homo sapiens_hsa047131.72132745
21Morphine addiction_Homo sapiens_hsa050321.71530548
22Vibrio cholerae infection_Homo sapiens_hsa051101.70427507
23Hedgehog signaling pathway_Homo sapiens_hsa043401.63068175
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.55710284
25Selenocompound metabolism_Homo sapiens_hsa004501.54480083
26Long-term potentiation_Homo sapiens_hsa047201.52799000
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.51768998
28Wnt signaling pathway_Homo sapiens_hsa043101.50972714
29Huntingtons disease_Homo sapiens_hsa050161.50358139
30Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.50162709
31Parkinsons disease_Homo sapiens_hsa050121.47742281
32Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.45697446
33Hippo signaling pathway_Homo sapiens_hsa043901.42678293
34Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.42204322
35Alzheimers disease_Homo sapiens_hsa050101.40350206
36Dopaminergic synapse_Homo sapiens_hsa047281.39287600
37Arginine and proline metabolism_Homo sapiens_hsa003301.37883567
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.35953927
39Serotonergic synapse_Homo sapiens_hsa047261.35335952
40Olfactory transduction_Homo sapiens_hsa047401.32341086
41Folate biosynthesis_Homo sapiens_hsa007901.31915120
42Gap junction_Homo sapiens_hsa045401.31716019
43Salivary secretion_Homo sapiens_hsa049701.30082611
44Base excision repair_Homo sapiens_hsa034101.29451472
45Steroid biosynthesis_Homo sapiens_hsa001001.25250062
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.25102119
47ErbB signaling pathway_Homo sapiens_hsa040121.22228262
48Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.20015700
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.19281373
50Taste transduction_Homo sapiens_hsa047421.19068713
51Cardiac muscle contraction_Homo sapiens_hsa042601.18002228
52Sulfur relay system_Homo sapiens_hsa041221.16320813
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.14189627
54Sulfur metabolism_Homo sapiens_hsa009201.13481652
55Cocaine addiction_Homo sapiens_hsa050301.11404181
56Axon guidance_Homo sapiens_hsa043601.10191658
57Rheumatoid arthritis_Homo sapiens_hsa053231.05667485
58Renin secretion_Homo sapiens_hsa049241.05616465
59Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.02767852
60Gastric acid secretion_Homo sapiens_hsa049711.01607632
61Pyrimidine metabolism_Homo sapiens_hsa002400.99206587
62Proteasome_Homo sapiens_hsa030500.98015590
63Basal cell carcinoma_Homo sapiens_hsa052170.95333021
64GnRH signaling pathway_Homo sapiens_hsa049120.95175765
65Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.94816002
66Mismatch repair_Homo sapiens_hsa034300.93149391
67Dorso-ventral axis formation_Homo sapiens_hsa043200.92645870
68Estrogen signaling pathway_Homo sapiens_hsa049150.91891747
69Phagosome_Homo sapiens_hsa041450.91135498
70Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.89789959
71One carbon pool by folate_Homo sapiens_hsa006700.88894682
72MAPK signaling pathway_Homo sapiens_hsa040100.87709763
73Oxytocin signaling pathway_Homo sapiens_hsa049210.86775026
74Insulin secretion_Homo sapiens_hsa049110.81765449
75Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.81348567
76Vitamin B6 metabolism_Homo sapiens_hsa007500.80994225
77Calcium signaling pathway_Homo sapiens_hsa040200.80827698
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80052261
79Cysteine and methionine metabolism_Homo sapiens_hsa002700.78399994
80Oocyte meiosis_Homo sapiens_hsa041140.77773171
81Melanogenesis_Homo sapiens_hsa049160.75552430
82Phototransduction_Homo sapiens_hsa047440.72576256
83mTOR signaling pathway_Homo sapiens_hsa041500.68767294
84Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.66131643
85Cholinergic synapse_Homo sapiens_hsa047250.65567816
862-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.65373333
87Notch signaling pathway_Homo sapiens_hsa043300.65109614
88Fatty acid metabolism_Homo sapiens_hsa012120.65058972
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.64584027
90Homologous recombination_Homo sapiens_hsa034400.62359789
91TGF-beta signaling pathway_Homo sapiens_hsa043500.62247765
92Metabolic pathways_Homo sapiens_hsa011000.60958791
93Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60020495
94Ether lipid metabolism_Homo sapiens_hsa005650.59749988
95alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58537381
96cAMP signaling pathway_Homo sapiens_hsa040240.58002027
97Choline metabolism in cancer_Homo sapiens_hsa052310.56932716
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56428824
99Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.56420650
100Pyruvate metabolism_Homo sapiens_hsa006200.54309284
101Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.53732234
102Ras signaling pathway_Homo sapiens_hsa040140.53657801
103Linoleic acid metabolism_Homo sapiens_hsa005910.53334854
104Mineral absorption_Homo sapiens_hsa049780.53104053
105Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52618969
106Tight junction_Homo sapiens_hsa045300.52144336
107Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51989169
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.50964813
109RNA degradation_Homo sapiens_hsa030180.50777453
110Fructose and mannose metabolism_Homo sapiens_hsa000510.49833076
111Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49730460
112Spliceosome_Homo sapiens_hsa030400.49720983
113Purine metabolism_Homo sapiens_hsa002300.49514597
114Colorectal cancer_Homo sapiens_hsa052100.48562335
115Aldosterone synthesis and secretion_Homo sapiens_hsa049250.45862070
116Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.45342578
117VEGF signaling pathway_Homo sapiens_hsa043700.43769674
118African trypanosomiasis_Homo sapiens_hsa051430.42435546
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41757653
120Vascular smooth muscle contraction_Homo sapiens_hsa042700.41287471
121Butanoate metabolism_Homo sapiens_hsa006500.37813048
122Alcoholism_Homo sapiens_hsa050340.36627539
123Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.36013925
124Regulation of autophagy_Homo sapiens_hsa041400.35495453
125Prion diseases_Homo sapiens_hsa050200.35372821
126Sphingolipid signaling pathway_Homo sapiens_hsa040710.34718304
127Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.34451590
128Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.32234103
129Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.32102160
130Cell cycle_Homo sapiens_hsa041100.31748968
131cGMP-PKG signaling pathway_Homo sapiens_hsa040220.31362273
132Rap1 signaling pathway_Homo sapiens_hsa040150.29329687
133Retinol metabolism_Homo sapiens_hsa008300.28663677
134Peroxisome_Homo sapiens_hsa041460.27978407
135Biosynthesis of amino acids_Homo sapiens_hsa012300.27464918
136Drug metabolism - other enzymes_Homo sapiens_hsa009830.25535740
137Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.25439884
138Autoimmune thyroid disease_Homo sapiens_hsa053200.24767822
139Bladder cancer_Homo sapiens_hsa052190.23314858
140Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.22475673
141Renin-angiotensin system_Homo sapiens_hsa046140.22124774
142Glutathione metabolism_Homo sapiens_hsa004800.21543668
143p53 signaling pathway_Homo sapiens_hsa041150.19317863
144Thyroid hormone synthesis_Homo sapiens_hsa049180.19252944
145RNA transport_Homo sapiens_hsa030130.18444507

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