NPNT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glomerular basement membrane development (GO:0032836)9.21020328
2surfactant homeostasis (GO:0043129)6.24624551
3glomerulus development (GO:0032835)5.77431507
4chemical homeostasis within a tissue (GO:0048875)4.83340730
5vascular endothelial growth factor signaling pathway (GO:0038084)4.30689003
6mesodermal cell differentiation (GO:0048333)4.25804198
7renal filtration (GO:0097205)4.21177351
8lymphangiogenesis (GO:0001946)4.18864667
9thyroid hormone generation (GO:0006590)4.17109000
10axon extension involved in axon guidance (GO:0048846)4.02866324
11neuron projection extension involved in neuron projection guidance (GO:1902284)4.02866324
12regulation of axon guidance (GO:1902667)3.95541565
13cell migration involved in sprouting angiogenesis (GO:0002042)3.87529485
14negative regulation of axon guidance (GO:1902668)3.80400307
15bundle of His cell to Purkinje myocyte communication (GO:0086069)3.76708640
16epithelial cell differentiation involved in kidney development (GO:0035850)3.72331357
17positive regulation of p38MAPK cascade (GO:1900745)3.72218843
18endothelial cell chemotaxis (GO:0035767)3.65640638
19thyroid hormone metabolic process (GO:0042403)3.63315400
20lung vasculature development (GO:0060426)3.62217248
21protein heterotrimerization (GO:0070208)3.61103792
22regulation of axon extension involved in axon guidance (GO:0048841)3.60878460
23wound healing, spreading of epidermal cells (GO:0035313)3.60209477
24cellular response to nitric oxide (GO:0071732)3.59609024
25peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.59491824
26epithelial cell-cell adhesion (GO:0090136)3.55222254
27kidney mesenchyme development (GO:0072074)3.49465629
28metanephric mesenchyme development (GO:0072075)3.47551740
29coronary vasculature morphogenesis (GO:0060977)3.43070219
30regulation of glomerular filtration (GO:0003093)3.40432492
31dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.39643287
32protein localization to endosome (GO:0036010)3.35820718
33regulation of cardioblast differentiation (GO:0051890)3.30036775
34intestinal epithelial cell development (GO:0060576)3.29611711
35stress fiber assembly (GO:0043149)3.27756409
36lymph vessel development (GO:0001945)3.25834369
37striated muscle atrophy (GO:0014891)3.23925061
38metanephric epithelium development (GO:0072207)3.22705088
39desmosome organization (GO:0002934)3.20712824
40negative regulation of axon extension involved in axon guidance (GO:0048843)3.19263740
41hippo signaling (GO:0035329)3.18030863
42excretion (GO:0007588)3.13776391
43toxin metabolic process (GO:0009404)3.13732676
44hemidesmosome assembly (GO:0031581)3.12837927
45regulation of p38MAPK cascade (GO:1900744)3.09429831
46auditory receptor cell differentiation (GO:0042491)3.08935948
47branching involved in salivary gland morphogenesis (GO:0060445)3.07931343
48cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.07121214
49cytoskeletal anchoring at plasma membrane (GO:0007016)3.04424766
50negative regulation of protein localization to cell surface (GO:2000009)3.02628846
51glomerular filtration (GO:0003094)3.00965556
52keratan sulfate catabolic process (GO:0042340)3.00657964
53renal system process involved in regulation of blood volume (GO:0001977)2.99899982
54collagen fibril organization (GO:0030199)2.96375217
55blood vessel endothelial cell migration (GO:0043534)2.95259476
56regulation of transforming growth factor beta2 production (GO:0032909)2.95004578
57semaphorin-plexin signaling pathway (GO:0071526)2.93226430
58cellular response to reactive nitrogen species (GO:1902170)2.92117907
59respiratory tube development (GO:0030323)2.91590673
60ganglion development (GO:0061548)2.89270977
61regulation of hippo signaling (GO:0035330)2.87842372
62venous blood vessel morphogenesis (GO:0048845)2.87171288
63basement membrane organization (GO:0071711)2.87159387
64retina vasculature morphogenesis in camera-type eye (GO:0061299)2.86001867
65activation of Rac GTPase activity (GO:0032863)2.85183392
66substrate-dependent cell migration (GO:0006929)2.84083048
67myoblast fusion (GO:0007520)2.83580701
68vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.82995906
69polarized epithelial cell differentiation (GO:0030859)2.82150691
70* cell adhesion mediated by integrin (GO:0033627)2.79965786
71positive regulation of cell adhesion mediated by integrin (GO:0033630)2.79028870
72positive regulation of mesenchymal cell proliferation (GO:0002053)2.78866648
73endodermal cell differentiation (GO:0035987)2.78135697
74metanephric nephron epithelium development (GO:0072243)2.76706074
75multicellular organismal catabolic process (GO:0044243)2.76703024
76multicellular organismal macromolecule metabolic process (GO:0044259)2.75747183
77metanephric tubule development (GO:0072170)2.74613140
78metanephric nephron tubule development (GO:0072234)2.74613140
79regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.74220429
80substrate adhesion-dependent cell spreading (GO:0034446)2.74143043
81plasma membrane repair (GO:0001778)2.73617379
82muscle atrophy (GO:0014889)2.71917448
83cardiac myofibril assembly (GO:0055003)2.70330593
84apoptotic cell clearance (GO:0043277)2.70127650
85camera-type eye morphogenesis (GO:0048593)2.68528278
86embryonic viscerocranium morphogenesis (GO:0048703)2.67841141
87collagen catabolic process (GO:0030574)2.65344354
88COPI coating of Golgi vesicle (GO:0048205)2.65275644
89Golgi transport vesicle coating (GO:0048200)2.65275644
90pattern specification involved in kidney development (GO:0061004)2.64959421
91regulation of extracellular matrix disassembly (GO:0010715)2.64624921
92chondrocyte proliferation (GO:0035988)2.64036388
93regulation of heart morphogenesis (GO:2000826)2.61682321
94endocardial cushion development (GO:0003197)2.61665787
95trivalent inorganic anion homeostasis (GO:0072506)2.61110810
96phosphate ion homeostasis (GO:0055062)2.61110810
97patterning of blood vessels (GO:0001569)2.60595955
98sarcomere organization (GO:0045214)2.60577888
99wound healing, spreading of cells (GO:0044319)2.60112051
100multicellular organismal metabolic process (GO:0044236)2.60007367
101collagen metabolic process (GO:0032963)2.59459859
102insulin-like growth factor receptor signaling pathway (GO:0048009)2.59192734
103regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.58737558
104actomyosin structure organization (GO:0031032)2.58574139
105muscle cell fate commitment (GO:0042693)2.58449742
106smooth muscle tissue development (GO:0048745)2.56939646
107regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.55970092
108positive regulation of endothelial cell differentiation (GO:0045603)2.55132333
109negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.54765254
110muscle cell migration (GO:0014812)2.54617742
111sodium ion homeostasis (GO:0055078)2.54420528
112skin morphogenesis (GO:0043589)2.54226030
113regulation of endothelial cell chemotaxis (GO:2001026)2.53720534
114COPII vesicle coating (GO:0048208)2.53648980
115regulation of endothelial cell differentiation (GO:0045601)2.52548417
116calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.52243118
117collecting duct development (GO:0072044)2.52179962
118syncytium formation by plasma membrane fusion (GO:0000768)2.52000665
119cellular response to vitamin D (GO:0071305)2.50767741
120negative regulation of complement activation (GO:0045916)2.50308925
121myofibril assembly (GO:0030239)2.50241697
122response to nitric oxide (GO:0071731)2.50164391
123outflow tract septum morphogenesis (GO:0003148)2.49201207
124endocrine hormone secretion (GO:0060986)2.48996870
125positive regulation of catenin import into nucleus (GO:0035413)2.48935715
126angiotensin maturation (GO:0002003)2.48660517
127blood vessel remodeling (GO:0001974)2.47712506
128norepinephrine metabolic process (GO:0042415)2.46358327
129regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.46238353
130regulation of integrin-mediated signaling pathway (GO:2001044)2.46112458
131phenol-containing compound catabolic process (GO:0019336)2.45667457
132cell-substrate junction assembly (GO:0007044)2.45214606
133hormone catabolic process (GO:0042447)2.45023426
134blood vessel maturation (GO:0001955)2.43974105
135regulation of protein localization to cell surface (GO:2000008)2.43412997
136regulation of mesenchymal cell proliferation (GO:0010464)2.43245092
137hypotonic response (GO:0006971)2.42710352
138ventricular cardiac muscle cell action potential (GO:0086005)2.40049468
139negative regulation of protein activation cascade (GO:2000258)2.38270103
140sequestering of extracellular ligand from receptor (GO:0035581)2.37803696
141cellular sodium ion homeostasis (GO:0006883)2.36801622
142toxin transport (GO:1901998)2.36085139
143negative regulation of fatty acid transport (GO:2000192)2.35165178
144skeletal muscle adaptation (GO:0043501)2.34697648
145multicellular organismal water homeostasis (GO:0050891)2.34164496
146actin-mediated cell contraction (GO:0070252)2.33036851
147mesenchyme morphogenesis (GO:0072132)2.31517258
148actin-myosin filament sliding (GO:0033275)2.26254900
149muscle filament sliding (GO:0030049)2.26254900
150peptide hormone processing (GO:0016486)2.26149731
151regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.26140804
152columnar/cuboidal epithelial cell development (GO:0002066)2.25053995
153macroautophagy (GO:0016236)2.23132577
154regulation of pseudopodium assembly (GO:0031272)2.22774622
155regulation of fatty acid oxidation (GO:0046320)2.22173865
156cell communication involved in cardiac conduction (GO:0086065)2.21855599
157cellular response to antibiotic (GO:0071236)2.21596622
158renal absorption (GO:0070293)2.21111266
159positive regulation of fatty acid beta-oxidation (GO:0032000)2.19207884
160negative regulation of hormone metabolic process (GO:0032351)2.18715293
161lung secretory cell differentiation (GO:0061140)2.18436589
162positive regulation of glycoprotein metabolic process (GO:1903020)2.17711767
163endocardial cushion morphogenesis (GO:0003203)2.16263278
164cGMP biosynthetic process (GO:0006182)2.14224981
165regulation of fatty acid beta-oxidation (GO:0031998)2.14145689
166epoxygenase P450 pathway (GO:0019373)2.13911679
167positive regulation of digestive system process (GO:0060456)2.13851272
168positive regulation of pseudopodium assembly (GO:0031274)2.12228163
169negative regulation of hormone biosynthetic process (GO:0032353)2.10889456
170regulation of vasculogenesis (GO:2001212)2.10262080
171actin filament depolymerization (GO:0030042)2.09204718
172negative regulation of cell size (GO:0045792)2.09164047
173hair cell differentiation (GO:0035315)2.08386923
174embryonic foregut morphogenesis (GO:0048617)2.08251357
175renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.08167179
176lung lobe morphogenesis (GO:0060463)2.07399322
177cellular zinc ion homeostasis (GO:0006882)2.07354436
178tight junction assembly (GO:0070830)2.06103298
179cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.05305728
180endocrine process (GO:0050886)2.05074817
181glomerular visceral epithelial cell development (GO:0072015)11.3758974
182glomerular epithelial cell development (GO:0072310)10.2815330

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.94457906
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.88947037
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.15448072
4ESR1_21235772_ChIP-Seq_MCF-7_Human3.06803232
5CLOCK_20551151_ChIP-Seq_293T_Human2.92571428
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.67842706
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.38638897
8WT1_19549856_ChIP-ChIP_CCG9911_Human2.38514706
9ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.25269904
10* ESR2_21235772_ChIP-Seq_MCF-7_Human2.24315862
11EP300_21415370_ChIP-Seq_HL-1_Mouse2.18835565
12WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.14599105
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.08413557
14ZNF217_24962896_ChIP-Seq_MCF-7_Human1.96614431
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.95606686
16TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.86133945
17ESR1_20079471_ChIP-ChIP_T-47D_Human1.84425472
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.78273417
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.76729760
20EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.76245998
21SMAD_19615063_ChIP-ChIP_OVARY_Human1.70582910
22GATA2_21666600_ChIP-Seq_HMVEC_Human1.70165072
23RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.69876495
24TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.68420264
25WT1_25993318_ChIP-Seq_PODOCYTE_Human1.67729427
26* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.67703110
27AHR_22903824_ChIP-Seq_MCF-7_Human1.66992623
28PPAR_26484153_Chip-Seq_NCI-H1993_Human1.63955053
29* CJUN_26792858_Chip-Seq_BT549_Human1.63096249
30STAT6_21828071_ChIP-Seq_BEAS2B_Human1.62685563
31* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.60527395
32SOX9_24532713_ChIP-Seq_HFSC_Mouse1.57195427
33SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.56408959
34FOXO3_23340844_ChIP-Seq_DLD1_Human1.56090494
35* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.55544734
36* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.55544734
37* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.55164526
38TCF4_18268006_ChIP-ChIP_LS174T_Human1.52586122
39SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.50757224
40CDX2_19796622_ChIP-Seq_MESCs_Mouse1.45948025
41* SOX2_20726797_ChIP-Seq_SW620_Human1.44959089
42ARNT_22903824_ChIP-Seq_MCF-7_Human1.44057855
43* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.43906092
44* EED_16625203_ChIP-ChIP_MESCs_Mouse1.42753389
45* GATA3_24758297_ChIP-Seq_MCF-7_Human1.40427686
46LXR_22158963_ChIP-Seq_LIVER_Mouse1.40406152
47TP53_18474530_ChIP-ChIP_U2OS_Human1.39234441
48CDX2_20551321_ChIP-Seq_CACO-2_Human1.37560362
49BRD4_25478319_ChIP-Seq_HGPS_Human1.36941904
50* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.36483936
51* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.35893930
52KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.33596882
53SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.33144690
54CTNNB1_20460455_ChIP-Seq_HCT116_Human1.33059394
55GBX2_23144817_ChIP-Seq_PC3_Human1.32271631
56TBX20_22328084_ChIP-Seq_HEART_Mouse1.32060443
57TBX20_22080862_ChIP-Seq_HEART_Mouse1.32060443
58SALL4_18804426_ChIP-ChIP_XEN_Mouse1.31605719
59RBPJ_22232070_ChIP-Seq_NCS_Mouse1.29690584
60KDM2B_26808549_Chip-Seq_K562_Human1.28867923
61* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.27853161
62JARID2_20075857_ChIP-Seq_MESCs_Mouse1.27087588
63FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.26211421
64TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.25981637
65SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.25157499
66P300_27058665_Chip-Seq_ZR-75-30cells_Human1.24367900
67CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.23604756
68* ERG_21242973_ChIP-ChIP_JURKAT_Human1.23415390
69GATA1_22025678_ChIP-Seq_K562_Human1.22062832
70ISL1_27105846_Chip-Seq_CPCs_Mouse1.21962073
71TP53_20018659_ChIP-ChIP_R1E_Mouse1.21863003
72KDM2B_26808549_Chip-Seq_SUP-B15_Human1.21753625
73HIF1A_21447827_ChIP-Seq_MCF-7_Human1.21293467
74* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.20409830
75DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.19625917
76SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.19615708
77SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.19615708
78NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.19417466
79FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.19262096
80ELK3_25401928_ChIP-Seq_HUVEC_Human1.19199559
81NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18539119
82CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.16888528
83* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.16221192
84GATA6_25053715_ChIP-Seq_YYC3_Human1.16163590
85SMAD4_21799915_ChIP-Seq_A2780_Human1.15432670
86SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14347886
87FOXA1_25552417_ChIP-Seq_VCAP_Human1.13168645
88KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12967361
89JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10588068
90RACK7_27058665_Chip-Seq_MCF-7_Human1.10534477
91SMAD3_21741376_ChIP-Seq_HESCs_Human1.10146044
92PIAS1_25552417_ChIP-Seq_VCAP_Human1.09955674
93ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.09703207
94* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.09362653
95SMAD3_21741376_ChIP-Seq_EPCs_Human1.08594574
96THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.08506202
97ZFP281_18757296_ChIP-ChIP_E14_Mouse1.08226221
98NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08194784
99PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08089055
100FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.07235926
101* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.07115767
102OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07039766
103RUNX1_27514584_Chip-Seq_MCF-7_Human1.06471368
104SMAD4_21741376_ChIP-Seq_HESCs_Human1.06109739
105SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05190836
106YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05078816
107EZH2_27294783_Chip-Seq_ESCs_Mouse1.05073517
108RXR_22158963_ChIP-Seq_LIVER_Mouse1.04915264
109ER_23166858_ChIP-Seq_MCF-7_Human1.04548589
110RNF2_27304074_Chip-Seq_ESCs_Mouse1.04535597
111* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.03854454
112* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.03854454
113BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03784992
114ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03674167
115RXR_22108803_ChIP-Seq_LS180_Human1.03578812
116TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03395216
117ZFP57_27257070_Chip-Seq_ESCs_Mouse1.02999857
118* KLF5_25053715_ChIP-Seq_YYC3_Human1.02426757
119BP1_19119308_ChIP-ChIP_Hs578T_Human1.01980071
120SMC1_22415368_ChIP-Seq_MEFs_Mouse1.01589915
121UBF1/2_26484160_Chip-Seq_HMECs_Human1.01566914
122* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.01466814
123BCAT_22108803_ChIP-Seq_LS180_Human0.98780800
124NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98470771
125ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.98219747
126GATA4_25053715_ChIP-Seq_YYC3_Human0.97783251
127PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.97498365
128TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.97409841
129SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96509045
130* FOXA2_19822575_ChIP-Seq_HepG2_Human0.96369022
131STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.95947249
132SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.94930684
133CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.94862052
134TP63_23658742_ChIP-Seq_EP156T_Human0.94854524
135POU3F2_20337985_ChIP-ChIP_501MEL_Human0.94436703
136EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.94282056
137* RING1B_27294783_Chip-Seq_NPCs_Mouse0.94237348
138* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.89993220
139* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89308262
140ZNF263_19887448_ChIP-Seq_K562_Human0.89300075
141CDX2_22108803_ChIP-Seq_LS180_Human0.88020618
142* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.87990908
143STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.86671270
144TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86051569
145DROSHA_22980978_ChIP-Seq_HELA_Human0.85100984

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004272_abnormal_basement_membrane3.87617282
2MP0005623_abnormal_meninges_morphology3.86822916
3MP0010368_abnormal_lymphatic_system3.47463986
4MP0004264_abnormal_extraembryonic_tissu3.27606464
5MP0000537_abnormal_urethra_morphology3.08240856
6MP0001958_emphysema2.99667753
7MP0001879_abnormal_lymphatic_vessel2.88497584
8MP0010030_abnormal_orbit_morphology2.77968563
9MP0000534_abnormal_ureter_morphology2.47736430
10MP0008438_abnormal_cutaneous_collagen2.47639967
11MP0000383_abnormal_hair_follicle2.39797472
12MP0003705_abnormal_hypodermis_morpholog2.36185522
13MP0005503_abnormal_tendon_morphology2.31982570
14MP0003566_abnormal_cell_adhesion2.16166877
15MP0002909_abnormal_adrenal_gland2.14097904
16MP0005275_abnormal_skin_tensile2.07763965
17MP0009384_cardiac_valve_regurgitation1.97079806
18MP0006054_spinal_hemorrhage1.96334343
19MP0004084_abnormal_cardiac_muscle1.93396758
20MP0001666_abnormal_nutrient_absorption1.92388314
21* MP0003942_abnormal_urinary_system1.83688640
22MP0003941_abnormal_skin_development1.80294436
23MP0002876_abnormal_thyroid_physiology1.78394774
24MP0003279_aneurysm1.76675994
25MP0002896_abnormal_bone_mineralization1.76083195
26MP0004270_analgesia1.75657026
27MP0002138_abnormal_hepatobiliary_system1.74189157
28MP0003283_abnormal_digestive_organ1.72786080
29MP0010234_abnormal_vibrissa_follicle1.68664070
30MP0009780_abnormal_chondrocyte_physiolo1.68476261
31MP0000013_abnormal_adipose_tissue1.65320867
32MP0003091_abnormal_cell_migration1.63825069
33MP0001664_abnormal_digestion1.62214406
34MP0005360_urolithiasis1.61881162
35MP0003300_gastrointestinal_ulcer1.60712923
36MP0000733_abnormal_muscle_development1.59466129
37MP0004215_abnormal_myocardial_fiber1.59403238
38MP0003115_abnormal_respiratory_system1.58879176
39MP0005167_abnormal_blood-brain_barrier1.58579262
40MP0005409_darkened_coat_color1.55875697
41MP0008775_abnormal_heart_ventricle1.55274629
42MP0002098_abnormal_vibrissa_morphology1.54084646
43MP0009643_abnormal_urine_homeostasis1.52751605
44MP0001756_abnormal_urination1.51537184
45MP0002136_abnormal_kidney_physiology1.50743155
46MP0000751_myopathy1.50704017
47MP0002877_abnormal_melanocyte_morpholog1.49483786
48MP0004019_abnormal_vitamin_homeostasis1.48294297
49MP0004043_abnormal_pH_regulation1.44313747
50MP0000681_abnormal_thyroid_gland1.43915428
51MP0003950_abnormal_plasma_membrane1.41371323
52MP0002295_abnormal_pulmonary_circulatio1.39061869
53MP0003868_abnormal_feces_composition1.37756613
54MP0000767_abnormal_smooth_muscle1.37021217
55MP0005508_abnormal_skeleton_morphology1.36854638
56MP0005085_abnormal_gallbladder_physiolo1.36518646
57MP0001299_abnormal_eye_distance/1.33103917
58MP0000516_abnormal_urinary_system1.32657797
59MP0005367_renal/urinary_system_phenotyp1.32657797
60MP0008961_abnormal_basal_metabolism1.30665331
61MP0009250_abnormal_appendicular_skeleto1.29906016
62MP0002837_dystrophic_cardiac_calcinosis1.29810841
63* MP0002135_abnormal_kidney_morphology1.28798673
64MP0000538_abnormal_urinary_bladder1.28445985
65MP0009053_abnormal_anal_canal1.27722651
66MP0002139_abnormal_hepatobiliary_system1.26523907
67MP0009840_abnormal_foam_cell1.24094725
68MP0000163_abnormal_cartilage_morphology1.23867172
69MP0002234_abnormal_pharynx_morphology1.22503852
70MP0008995_early_reproductive_senescence1.21667223
71MP0004085_abnormal_heartbeat1.19499439
72MP0010352_gastrointestinal_tract_polyps1.19366170
73MP0003385_abnormal_body_wall1.19275772
74MP0000566_synostosis1.19129400
75MP0004484_altered_response_of1.18529397
76MP0001346_abnormal_lacrimal_gland1.18194287
77MP0001849_ear_inflammation1.17195124
78MP0005620_abnormal_muscle_contractility1.16798102
79MP0002282_abnormal_trachea_morphology1.16522837
80MP0004782_abnormal_surfactant_physiolog1.16502811
81MP0000427_abnormal_hair_cycle1.16409419
82MP0000749_muscle_degeneration1.13854009
83MP0000678_abnormal_parathyroid_gland1.13033238
84MP0003935_abnormal_craniofacial_develop1.11812426
85MP0002233_abnormal_nose_morphology1.10729821
86MP0000230_abnormal_systemic_arterial1.09566763
87MP0001765_abnormal_ion_homeostasis1.09532213
88MP0000762_abnormal_tongue_morphology1.08601083
89MP0002932_abnormal_joint_morphology1.08397847
90MP0005330_cardiomyopathy1.07552451
91MP0001542_abnormal_bone_strength1.07083580
92MP0010329_abnormal_lipoprotein_level1.05896467
93MP0000579_abnormal_nail_morphology1.05673324
94MP0001270_distended_abdomen1.05419569
95MP0000462_abnormal_digestive_system1.05077056
96MP0005332_abnormal_amino_acid1.04914481
97MP0005023_abnormal_wound_healing1.04031605
98MP0002972_abnormal_cardiac_muscle1.03800841
99MP0002115_abnormal_skeleton_extremities1.03578728
100MP0002127_abnormal_cardiovascular_syste1.03311634
101MP0002128_abnormal_blood_circulation1.02247008
102MP0002925_abnormal_cardiovascular_devel1.01021896
103MP0008004_abnormal_stomach_pH1.00917203
104MP0005365_abnormal_bile_salt1.00095784
105MP0002168_other_aberrant_phenotype0.99940019
106MP0001614_abnormal_blood_vessel0.99824093
107MP0004036_abnormal_muscle_relaxation0.97319263
108MP0003183_abnormal_peptide_metabolism0.96943376
109MP0003937_abnormal_limbs/digits/tail_de0.95558185
110MP0003137_abnormal_impulse_conducting0.95293392
111MP0000003_abnormal_adipose_tissue0.94039444
112MP0001501_abnormal_sleep_pattern0.93544322
113MP0004233_abnormal_muscle_weight0.93268479
114MP0002108_abnormal_muscle_morphology0.92104764
115MP0002113_abnormal_skeleton_development0.92067560
116MP0005076_abnormal_cell_differentiation0.91649840
117MP0006138_congestive_heart_failure0.90642737
118MP0000747_muscle_weakness0.90260560
119MP0002133_abnormal_respiratory_system0.90116735
120MP0005388_respiratory_system_phenotype0.90116735
121MP0005257_abnormal_intraocular_pressure0.89858201
122MP0005197_abnormal_uvea_morphology0.89748441
123MP0009379_abnormal_foot_pigmentation0.88836708
124MP0005248_abnormal_Harderian_gland0.87778527
125MP0010678_abnormal_skin_adnexa0.87117246
126MP0002697_abnormal_eye_size0.86274445
127MP0001784_abnormal_fluid_regulation0.84437344
128MP0004087_abnormal_muscle_fiber0.84013072
129MP0005187_abnormal_penis_morphology0.83580610
130MP0003879_abnormal_hair_cell0.83235394
131MP0005595_abnormal_vascular_smooth0.82992035
132MP0002998_abnormal_bone_remodeling0.82851220
133MP0002249_abnormal_larynx_morphology0.82533806
134MP0001175_abnormal_lung_morphology0.82306296
135MP0001177_atelectasis0.81583293
136MP0002116_abnormal_craniofacial_bone0.81505890
137MP0003755_abnormal_palate_morphology0.81366860
138MP0005193_abnormal_anterior_eye0.81146617
139MP0002796_impaired_skin_barrier0.80883085
140MP0000750_abnormal_muscle_regeneration0.79621095
141MP0000428_abnormal_craniofacial_morphol0.79493830
142MP0001661_extended_life_span0.78964015
143MP0004883_abnormal_blood_vessel0.77653492
144MP0004885_abnormal_endolymph0.77490806
145MP0000432_abnormal_head_morphology0.77364575
146MP0005636_abnormal_mineral_homeostasis0.74096589
147MP0002118_abnormal_lipid_homeostasis0.73502815
148MP0004147_increased_porphyrin_level0.72637311
149MP0002822_catalepsy0.72498183
150MP0000377_abnormal_hair_follicle0.71044232
151MP0005220_abnormal_exocrine_pancreas0.68218527
152MP0002269_muscular_atrophy0.67097186
153MP0002060_abnormal_skin_morphology0.65647252
154MP0005164_abnormal_response_to0.64369892

Predicted human phenotypes

RankGene SetZ-score
1Focal segmental glomerulosclerosis (HP:0000097)5.65448887
2Glomerulosclerosis (HP:0000096)4.71595823
3Mesangial abnormality (HP:0001966)4.68291550
4Hyperactive renin-angiotensin system (HP:0000841)4.66197430
5Hypokalemic alkalosis (HP:0001949)3.76446165
6Right ventricular cardiomyopathy (HP:0011663)3.70382205
7Protrusio acetabuli (HP:0003179)3.68333638
8Abnormal albumin level (HP:0012116)3.55083299
9Hypoalbuminemia (HP:0003073)3.55083299
10Ankle contracture (HP:0006466)3.51189282
11Premature rupture of membranes (HP:0001788)3.42768281
12Abnormality of chloride homeostasis (HP:0011422)3.36960208
13Tubular atrophy (HP:0000092)3.26218830
14Malnutrition (HP:0004395)3.25680752
15Increased circulating renin level (HP:0000848)3.16361981
16Proximal tubulopathy (HP:0000114)3.15482471
17Decreased circulating renin level (HP:0003351)3.07913715
18Interstitial pulmonary disease (HP:0006530)3.07717869
19Hyperventilation (HP:0002883)3.06325255
20Stage 5 chronic kidney disease (HP:0003774)3.04664865
21Goiter (HP:0000853)3.03413672
22Atrophic scars (HP:0001075)2.98418736
23Aplasia of the musculature (HP:0100854)2.97168630
24Potter facies (HP:0002009)2.95139214
25Facial shape deformation (HP:0011334)2.95139214
26Abnormality of glutamine family amino acid metabolism (HP:0010902)2.93232614
27Shallow orbits (HP:0000586)2.92464751
28Nephritis (HP:0000123)2.91299047
29Distal arthrogryposis (HP:0005684)2.89890724
30Lymphangioma (HP:0100764)2.88923857
31Sudden death (HP:0001699)2.88204155
32Renal salt wasting (HP:0000127)2.86595825
33Broad metatarsal (HP:0001783)2.85502691
34Tubulointerstitial fibrosis (HP:0005576)2.78802186
35Syncope (HP:0001279)2.77965987
36Aortic dissection (HP:0002647)2.76933631
37Hematochezia (HP:0002573)2.76262760
38Pterygium (HP:0001059)2.75226394
39Neonatal respiratory distress (HP:0002643)2.73736649
40Type 1 muscle fiber predominance (HP:0003803)2.69384480
41Cerebral aneurysm (HP:0004944)2.68546133
42Fetal akinesia sequence (HP:0001989)2.66110141
43Metabolic alkalosis (HP:0200114)2.64998620
44Aortic aneurysm (HP:0004942)2.63082352
45Hyperaldosteronism (HP:0000859)2.58972278
46Abnormality of renin-angiotensin system (HP:0000847)2.57387727
47Hip contracture (HP:0003273)2.55654223
48Hypomagnesemia (HP:0002917)2.55019135
49Congenital malformation of the right heart (HP:0011723)2.54878210
50Double outlet right ventricle (HP:0001719)2.54878210
51Thyroid-stimulating hormone excess (HP:0002925)2.51317853
52Visceral angiomatosis (HP:0100761)2.49098592
53Abnormality of the ischium (HP:0003174)2.43714766
54Gout (HP:0001997)2.41195490
55Asymmetry of the thorax (HP:0001555)2.39454544
56Arterial tortuosity (HP:0005116)2.38988954
57Neonatal short-limb short stature (HP:0008921)2.38724961
58Tetany (HP:0001281)2.36996302
59Abdominal distention (HP:0003270)2.33878113
60Bundle branch block (HP:0011710)2.32273904
61Ventricular tachycardia (HP:0004756)2.30827298
62Polycythemia (HP:0001901)2.29935045
63Vascular tortuosity (HP:0004948)2.29758961
64Hemangiomatosis (HP:0007461)2.29465900
65J-shaped sella turcica (HP:0002680)2.27256184
66Asymmetric septal hypertrophy (HP:0001670)2.27251906
67Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.24858796
68Hydroxyprolinuria (HP:0003080)2.23183617
69Abnormality of proline metabolism (HP:0010907)2.23183617
70Knee flexion contracture (HP:0006380)2.21923304
71Metaphyseal dysplasia (HP:0100255)2.21705713
72Pulmonary artery stenosis (HP:0004415)2.21128351
73Mildly elevated creatine phosphokinase (HP:0008180)2.20089271
74Abnormal urine output (HP:0012590)2.19570446
75Growth hormone excess (HP:0000845)2.19181657
76Abnormality of renal excretion (HP:0011036)2.18693087
77Metaphyseal cupping (HP:0003021)2.17403839
78Ulnar deviation of the wrist (HP:0003049)2.16966217
79Polyuria (HP:0000103)2.15533166
80Tachypnea (HP:0002789)2.15187730
81Spinal rigidity (HP:0003306)2.14171527
82Hyporeflexia of lower limbs (HP:0002600)2.12735235
83Ventricular arrhythmia (HP:0004308)2.12547225
84Camptodactyly of toe (HP:0001836)2.12487201
85Akinesia (HP:0002304)2.12436429
86Atrial fibrillation (HP:0005110)2.12318638
87Gowers sign (HP:0003391)2.10876713
88Abnormality of the calf musculature (HP:0001430)2.09974043
89Exostoses (HP:0100777)2.09282141
90Cardiovascular calcification (HP:0011915)2.05647824
91Abnormality of magnesium homeostasis (HP:0004921)2.05088236
92Hypokalemia (HP:0002900)2.04886072
93Down-sloping shoulders (HP:0200021)2.04673917
94Vascular calcification (HP:0004934)2.04492320
95Long toe (HP:0010511)2.04101765
96Coronal craniosynostosis (HP:0004440)2.02200387
97Hypercalciuria (HP:0002150)2.01642540
98Striae distensae (HP:0001065)2.00960338
99Hypoplastic ischia (HP:0003175)2.00203207
100Rapidly progressive (HP:0003678)2.00202229
101Glomerulonephritis (HP:0000099)1.99016750
102Abnormality of placental membranes (HP:0011409)1.98445462
103Amniotic constriction ring (HP:0009775)1.98445462
104Cervical subluxation (HP:0003308)1.97695296
105Neoplasm of the heart (HP:0100544)1.97511368
106Pili torti (HP:0003777)1.96478892
107Increased CSF protein (HP:0002922)1.96240997
108Mitral stenosis (HP:0001718)1.95953151
109Persistence of primary teeth (HP:0006335)1.95834320
110Abnormality of dentin (HP:0010299)1.95819351
111Ulnar claw (HP:0001178)1.94601326
112Chondrocalcinosis (HP:0000934)1.94067476
113Increased variability in muscle fiber diameter (HP:0003557)1.93770424
114Aneurysm (HP:0002617)1.92375700
115Rectal prolapse (HP:0002035)1.91635567
116Fatigable weakness (HP:0003473)1.91077017
117Abnormality of the neuromuscular junction (HP:0003398)1.91077017
118Ulnar bowing (HP:0003031)1.91044000
119Nonprogressive disorder (HP:0003680)1.90793734
120Scapular winging (HP:0003691)1.90510901
121Abnormality of vitamin B metabolism (HP:0004340)1.90366315
122Calf muscle hypertrophy (HP:0008981)1.88502228
123Epiphyseal dysplasia (HP:0002656)1.88279815
124Abnormality of potassium homeostasis (HP:0011042)1.88141887
125Mitral valve prolapse (HP:0001634)1.87341875
126Congenital sensorineural hearing impairment (HP:0008527)1.86902614
127Increased connective tissue (HP:0009025)1.86228275
128Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)1.85125597
129Abnormality of skeletal muscle fiber size (HP:0012084)1.83364959
130Thin bony cortex (HP:0002753)1.82925633
131Wormian bones (HP:0002645)1.82805616
132Osteolytic defects of the hand bones (HP:0009699)1.82472830
133Osteolytic defects of the phalanges of the hand (HP:0009771)1.82472830
134Femoral bowing (HP:0002980)1.81767806
135Bladder diverticulum (HP:0000015)1.81310374
136Primary atrial arrhythmia (HP:0001692)1.81004542
137Abnormality of Sharpey fibers (HP:0100685)1.80496152
138Limited hip movement (HP:0008800)1.80387352
139Abnormality of calcium-phosphate metabolism (HP:0100530)1.80342189
140Hyperkalemia (HP:0002153)1.78869492
141Bell-shaped thorax (HP:0001591)1.76762423
142Exercise-induced myalgia (HP:0003738)1.76608455
143Shawl scrotum (HP:0000049)1.76345606
144Fragile skin (HP:0001030)1.75341878
145Popliteal pterygium (HP:0009756)1.75265377
146Follicular hyperkeratosis (HP:0007502)1.74813876
147Round ear (HP:0100830)1.74677500
148Osteoarthritis (HP:0002758)1.74408154
149Respiratory distress (HP:0002098)1.72885516
150Osteopenia (HP:0000938)1.72605411
151Adrenal overactivity (HP:0002717)1.72149882
152Difficulty climbing stairs (HP:0003551)1.71833453
153Thin ribs (HP:0000883)1.71758652
154Prolonged QT interval (HP:0001657)1.71599972
155Midline defect of the nose (HP:0004122)1.71589334
156Buphthalmos (HP:0000557)1.71178123
157Bicornuate uterus (HP:0000813)1.71144920
158Germ cell neoplasia (HP:0100728)1.71116100
159Venous insufficiency (HP:0005293)1.68660754
160Polydipsia (HP:0001959)1.68391979
161Abnormal drinking behavior (HP:0030082)1.68391979
162Distal lower limb muscle weakness (HP:0009053)1.68345488
163Abnormality of vitamin metabolism (HP:0100508)1.68159293
164Hematuria (HP:0000790)1.68047359
165Supraventricular tachycardia (HP:0004755)1.67132489
166Congenital glaucoma (HP:0001087)1.67079325
167Corneal erosion (HP:0200020)1.67014435
168Supraventricular arrhythmia (HP:0005115)1.66039434
169Generalized muscle weakness (HP:0003324)1.65821587

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK43.94033147
2EPHB23.86370670
3TIE13.52313885
4TRIB33.33837714
5OXSR13.15703536
6TGFBR23.15539919
7MUSK3.08052204
8DDR23.08031699
9LATS13.01764849
10PIK3CA2.93505173
11PAK42.91411214
12WNK32.51083488
13PDGFRA2.37346361
14SIK12.31218171
15LMTK22.27221293
16CASK2.12252767
17FER2.12104223
18LRRK22.04098420
19STK391.99537230
20ACVR1B1.95500512
21TTN1.94729581
22RIPK11.78284601
23MAP3K121.70418018
24EPHA21.67552729
25PTK61.67387426
26MAPKAPK31.66645941
27MYLK1.65941749
28TGFBR11.55271821
29AKT31.53218149
30EPHB11.47141589
31PTK21.44696524
32PKN21.44104150
33PAK21.42700112
34FGFR21.41713188
35SCYL21.38896925
36ERN11.37940782
37MST41.34584296
38PAK31.30723702
39NEK61.30271670
40EPHA41.29545012
41LATS21.27256145
42KDR1.24496455
43MOS1.20919978
44MAP3K21.15725002
45NTRK11.14738874
46OBSCN1.12114517
47MAP2K11.11040580
48PDGFRB1.09214583
49EPHA31.08552753
50NLK1.08376797
51ROCK11.03540704
52STK38L1.03190274
53ERBB41.02680768
54FGFR41.01939153
55RPS6KA21.01646789
56RPS6KB21.01126503
57STK101.00212544
58STK30.96289785
59BCR0.92072396
60FGFR10.89862260
61CAMK2G0.88176793
62CAMK2D0.87941901
63PTK2B0.87842645
64MET0.86744101
65WNK10.86437308
66FRK0.86020856
67PIK3CG0.85861959
68CHUK0.81442784
69ILK0.81228722
70CDC42BPA0.80953645
71DMPK0.80749878
72SGK20.79479292
73MAPK150.78370575
74DYRK1B0.75734793
75GSK3A0.75647229
76CSNK1G10.75481750
77MAP2K60.75261680
78CDK60.75202978
79PHKG10.74132145
80PHKG20.74132145
81ROCK20.73190599
82TRPM70.71205858
83STK240.69805824
84BMX0.69408833
85MAP3K70.69284953
86KSR20.68998553
87MTOR0.68287149
88SGK2230.68243258
89SGK4940.68243258
90GRK10.66984376
91RPS6KB10.62664932
92CSNK1G30.62629227
93MAPK110.62002170
94MELK0.59534311
95MAP3K30.59250358
96RET0.58910169
97PRKD10.57095725
98NTRK30.56173073
99PRKCH0.55746642
100MAP3K40.52518671
101FGFR30.51070682
102CAMK1G0.50550902
103MAP3K100.50025282
104CSNK1G20.49440797
105MAP3K60.47421983
106LIMK10.46564748
107PRKCZ0.46354041
108JAK10.46285947
109ERBB30.46203060
110MST1R0.45415325
111PRKCE0.44925148
112ERBB20.44657470
113CAMK2B0.44411266
114SRC0.42878523
115PDPK10.41891048
116NEK90.41215764
117PRKD30.41189794
118PRKG20.40707107
119TESK10.40183939
120PRKAA10.39795137
121CAMK1D0.38629424
122CAMK2A0.38167792
123DAPK20.38163197
124MAPK70.38159298
125PRKD20.37991242
126PAK60.37613080
127INSR0.37300964
128MARK20.36739595
129SGK30.36528469
130STK380.35439557
131EGFR0.35101030
132CDK140.34640135
133MAP2K20.33191471
134PDK20.31866922
135IGF1R0.30603664
136AKT20.29128055
137HIPK20.28694942
138TYRO30.28152690
139CDK150.27247537
140EEF2K0.25642399
141CDK120.25363551
142CDK180.24216893
143FYN0.23877241
144ADRBK10.23301742

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.01262284
2Focal adhesion_Homo sapiens_hsa045102.81068362
3Protein digestion and absorption_Homo sapiens_hsa049742.57576589
4Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.32622705
5Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.18546757
6Adherens junction_Homo sapiens_hsa045202.14110667
7Small cell lung cancer_Homo sapiens_hsa052222.01331832
8AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.00952745
9Amoebiasis_Homo sapiens_hsa051461.99887856
10Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.91079993
11Dilated cardiomyopathy_Homo sapiens_hsa054141.90941772
12Bladder cancer_Homo sapiens_hsa052191.90558039
13Renin-angiotensin system_Homo sapiens_hsa046141.89662703
14Proteoglycans in cancer_Homo sapiens_hsa052051.86018877
15Histidine metabolism_Homo sapiens_hsa003401.81304964
16Axon guidance_Homo sapiens_hsa043601.80853938
17Hippo signaling pathway_Homo sapiens_hsa043901.76550126
18Fat digestion and absorption_Homo sapiens_hsa049751.72575816
19Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.69783576
20Tight junction_Homo sapiens_hsa045301.64677622
21Vitamin digestion and absorption_Homo sapiens_hsa049771.55569797
22Leukocyte transendothelial migration_Homo sapiens_hsa046701.52539711
23Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.44796932
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.42771231
25Arginine biosynthesis_Homo sapiens_hsa002201.42721182
26Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.37749767
27Regulation of actin cytoskeleton_Homo sapiens_hsa048101.34635590
28ABC transporters_Homo sapiens_hsa020101.31814197
29Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.30302113
30Pancreatic secretion_Homo sapiens_hsa049721.30067912
31Circadian rhythm_Homo sapiens_hsa047101.28330041
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.26873079
33Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.24641799
34Tryptophan metabolism_Homo sapiens_hsa003801.23826235
35PI3K-Akt signaling pathway_Homo sapiens_hsa041511.23807888
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.23553733
37Pancreatic cancer_Homo sapiens_hsa052121.22839739
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.22416365
39Renal cell carcinoma_Homo sapiens_hsa052111.21330682
40Maturity onset diabetes of the young_Homo sapiens_hsa049501.20057460
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.19457710
42Pentose and glucuronate interconversions_Homo sapiens_hsa000401.19066012
43Basal cell carcinoma_Homo sapiens_hsa052171.17060891
44TGF-beta signaling pathway_Homo sapiens_hsa043501.14909700
45Rap1 signaling pathway_Homo sapiens_hsa040151.13739788
46Sphingolipid metabolism_Homo sapiens_hsa006001.10245810
47Caffeine metabolism_Homo sapiens_hsa002321.08868696
48Fructose and mannose metabolism_Homo sapiens_hsa000511.08792871
49Endometrial cancer_Homo sapiens_hsa052131.07238875
50PPAR signaling pathway_Homo sapiens_hsa033201.06472737
51Gastric acid secretion_Homo sapiens_hsa049711.06299976
52Chronic myeloid leukemia_Homo sapiens_hsa052201.04524751
53Linoleic acid metabolism_Homo sapiens_hsa005911.03595981
54MicroRNAs in cancer_Homo sapiens_hsa052061.01926960
55Glioma_Homo sapiens_hsa052141.01198507
56Thyroid hormone synthesis_Homo sapiens_hsa049180.99139055
57Hedgehog signaling pathway_Homo sapiens_hsa043400.98505499
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.97577693
59Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.94838567
60Platelet activation_Homo sapiens_hsa046110.94705934
61Pathways in cancer_Homo sapiens_hsa052000.93566164
62Starch and sucrose metabolism_Homo sapiens_hsa005000.92859462
63Fatty acid degradation_Homo sapiens_hsa000710.90083271
64Prostate cancer_Homo sapiens_hsa052150.89390426
65beta-Alanine metabolism_Homo sapiens_hsa004100.86428776
66Melanoma_Homo sapiens_hsa052180.86237180
67Wnt signaling pathway_Homo sapiens_hsa043100.85974268
68Renin secretion_Homo sapiens_hsa049240.85599020
69VEGF signaling pathway_Homo sapiens_hsa043700.85228701
70Ether lipid metabolism_Homo sapiens_hsa005650.83150986
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82879172
72Melanogenesis_Homo sapiens_hsa049160.81264576
73Vibrio cholerae infection_Homo sapiens_hsa051100.79156318
74Glycosaminoglycan degradation_Homo sapiens_hsa005310.79044012
75Gap junction_Homo sapiens_hsa045400.79006292
76Arginine and proline metabolism_Homo sapiens_hsa003300.78254991
77Phenylalanine metabolism_Homo sapiens_hsa003600.77905422
78Viral myocarditis_Homo sapiens_hsa054160.77395269
79mTOR signaling pathway_Homo sapiens_hsa041500.77152077
80Mineral absorption_Homo sapiens_hsa049780.76572822
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.75984864
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.75734067
83Endocytosis_Homo sapiens_hsa041440.75513098
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75432274
85Butanoate metabolism_Homo sapiens_hsa006500.75323701
86Glucagon signaling pathway_Homo sapiens_hsa049220.75106696
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.75003844
88Estrogen signaling pathway_Homo sapiens_hsa049150.74887315
89Bile secretion_Homo sapiens_hsa049760.74734267
90Chemical carcinogenesis_Homo sapiens_hsa052040.74437922
91Retinol metabolism_Homo sapiens_hsa008300.74006852
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.73742737
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.73701169
94Ovarian steroidogenesis_Homo sapiens_hsa049130.73483462
95Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.73374276
96Dorso-ventral axis formation_Homo sapiens_hsa043200.72090506
97Galactose metabolism_Homo sapiens_hsa000520.71643020
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71328018
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.69710910
100Lysosome_Homo sapiens_hsa041420.68806247
101Lysine degradation_Homo sapiens_hsa003100.67493302
102Fatty acid metabolism_Homo sapiens_hsa012120.67324065
103Amphetamine addiction_Homo sapiens_hsa050310.66599752
104Toxoplasmosis_Homo sapiens_hsa051450.63791918
105Other glycan degradation_Homo sapiens_hsa005110.63361635
106N-Glycan biosynthesis_Homo sapiens_hsa005100.62878254
107Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62657758
108Non-small cell lung cancer_Homo sapiens_hsa052230.61757077
109Colorectal cancer_Homo sapiens_hsa052100.61586704
110Cocaine addiction_Homo sapiens_hsa050300.60877669
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58866835
112Aldosterone synthesis and secretion_Homo sapiens_hsa049250.58205469
113Phospholipase D signaling pathway_Homo sapiens_hsa040720.57626257
114Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57339299
115Insulin resistance_Homo sapiens_hsa049310.56933247
116Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56793623
117Tyrosine metabolism_Homo sapiens_hsa003500.55788400
118Salivary secretion_Homo sapiens_hsa049700.55582393
119Notch signaling pathway_Homo sapiens_hsa043300.55080683
120Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.54455601
121Nitrogen metabolism_Homo sapiens_hsa009100.53555497
122Oxytocin signaling pathway_Homo sapiens_hsa049210.52378155
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52174270
124Insulin signaling pathway_Homo sapiens_hsa049100.52119875
125Ras signaling pathway_Homo sapiens_hsa040140.52027167
126Arachidonic acid metabolism_Homo sapiens_hsa005900.51809233
127Inositol phosphate metabolism_Homo sapiens_hsa005620.51740630
128Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51380378
129Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51326175
130ErbB signaling pathway_Homo sapiens_hsa040120.51070250
131Central carbon metabolism in cancer_Homo sapiens_hsa052300.49152716
132Phagosome_Homo sapiens_hsa041450.48950196
133FoxO signaling pathway_Homo sapiens_hsa040680.48573511
134Shigellosis_Homo sapiens_hsa051310.47827434
135Neurotrophin signaling pathway_Homo sapiens_hsa047220.47584695
136Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47441119
137Complement and coagulation cascades_Homo sapiens_hsa046100.47197273
138Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46763617
139Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46569358
140Fatty acid elongation_Homo sapiens_hsa000620.46527401
141Collecting duct acid secretion_Homo sapiens_hsa049660.45983290
142Sulfur metabolism_Homo sapiens_hsa009200.45862008
143Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.44880841
144GnRH signaling pathway_Homo sapiens_hsa049120.44489626
145Thyroid cancer_Homo sapiens_hsa052160.44294060
146Glycerophospholipid metabolism_Homo sapiens_hsa005640.44207355
147Long-term depression_Homo sapiens_hsa047300.43379283
148Hepatitis C_Homo sapiens_hsa051600.43280715
149Choline metabolism in cancer_Homo sapiens_hsa052310.42736784
150Insulin secretion_Homo sapiens_hsa049110.42149962
151cAMP signaling pathway_Homo sapiens_hsa040240.41877790
152AMPK signaling pathway_Homo sapiens_hsa041520.34898888
153Cyanoamino acid metabolism_Homo sapiens_hsa004600.34680215

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