NPM1P39

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.53553465
2proteasome assembly (GO:0043248)4.43938987
3rRNA modification (GO:0000154)4.35938228
4tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.26284079
5RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.26284079
6rRNA methylation (GO:0031167)4.01270274
7establishment of protein localization to mitochondrial membrane (GO:0090151)3.89778805
8pseudouridine synthesis (GO:0001522)3.72006589
9chromatin remodeling at centromere (GO:0031055)3.68830370
10mitochondrial RNA metabolic process (GO:0000959)3.65805588
11CENP-A containing nucleosome assembly (GO:0034080)3.61169902
12respiratory chain complex IV assembly (GO:0008535)3.51415415
13somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.48347529
14somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.48347529
15isotype switching (GO:0045190)3.48347529
16maturation of 5.8S rRNA (GO:0000460)3.47394454
17DNA double-strand break processing (GO:0000729)3.46046773
18negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.45596156
19mitochondrial respiratory chain complex I assembly (GO:0032981)3.41334728
20NADH dehydrogenase complex assembly (GO:0010257)3.41334728
21mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.41334728
22water-soluble vitamin biosynthetic process (GO:0042364)3.37172517
23chaperone-mediated protein transport (GO:0072321)3.36226501
24IMP biosynthetic process (GO:0006188)3.31414723
25transcription elongation from RNA polymerase III promoter (GO:0006385)3.31030553
26termination of RNA polymerase III transcription (GO:0006386)3.31030553
27protein complex biogenesis (GO:0070271)3.29105566
28regulation of cellular amino acid metabolic process (GO:0006521)3.28813693
29replication fork processing (GO:0031297)3.27100632
30DNA catabolic process, exonucleolytic (GO:0000738)3.26225087
31DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.25674637
32ribosome assembly (GO:0042255)3.25376191
33signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.24212004
34signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.24212004
35signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.24212004
36mitochondrial respiratory chain complex assembly (GO:0033108)3.23846578
37exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.23026653
38nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.23011665
39positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.22175507
40protein-cofactor linkage (GO:0018065)3.22024816
41DNA replication-dependent nucleosome organization (GO:0034723)3.21187028
42DNA replication-dependent nucleosome assembly (GO:0006335)3.21187028
43tRNA processing (GO:0008033)3.19847844
44synapsis (GO:0007129)3.19761496
45signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.17435329
46intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.17435329
47folic acid-containing compound biosynthetic process (GO:0009396)3.16814697
48regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.14162966
49tRNA modification (GO:0006400)3.11574844
50RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.11156799
51ribosome biogenesis (GO:0042254)3.10314568
52signal transduction involved in DNA damage checkpoint (GO:0072422)3.09414632
53signal transduction involved in DNA integrity checkpoint (GO:0072401)3.09414632
54resolution of meiotic recombination intermediates (GO:0000712)3.09185485
55signal transduction involved in cell cycle checkpoint (GO:0072395)3.08935758
56histone exchange (GO:0043486)3.08915620
57regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.06677689
58negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.05738280
59negative regulation of ligase activity (GO:0051352)3.05738280
60regulation of mitotic spindle checkpoint (GO:1903504)3.04507337
61regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.04507337
62negative regulation of DNA-dependent DNA replication (GO:2000104)3.03802613
63protein deneddylation (GO:0000338)3.02229166
64positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.01946196
65cullin deneddylation (GO:0010388)3.00976947
66ATP synthesis coupled proton transport (GO:0015986)3.00620869
67energy coupled proton transport, down electrochemical gradient (GO:0015985)3.00620869
68protein neddylation (GO:0045116)2.97952954
69viral mRNA export from host cell nucleus (GO:0046784)2.97647059
70tRNA metabolic process (GO:0006399)2.96558853
71rRNA processing (GO:0006364)2.94841577
72ribosomal small subunit assembly (GO:0000028)2.92856188
73aldehyde catabolic process (GO:0046185)2.92657590
74response to pheromone (GO:0019236)2.92324613
75anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.89082929
76IMP metabolic process (GO:0046040)2.88145191
77cytochrome complex assembly (GO:0017004)2.86938425
78rRNA metabolic process (GO:0016072)2.85435909
79regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.85425253
80transcription from mitochondrial promoter (GO:0006390)2.81672319
81mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.81011723
82cytidine catabolic process (GO:0006216)2.80454116
83cytidine deamination (GO:0009972)2.80454116
84cytidine metabolic process (GO:0046087)2.80454116
85formation of translation preinitiation complex (GO:0001731)2.78794951
86mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.74009761
87regulation of immunoglobulin secretion (GO:0051023)2.73287423
88cornea development in camera-type eye (GO:0061303)2.73273557
89positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.72439127
90adenosine metabolic process (GO:0046085)2.71416603
91platelet dense granule organization (GO:0060155)2.71246111
92regulation of centriole replication (GO:0046599)2.70835073
93transcription elongation from RNA polymerase I promoter (GO:0006362)2.70330737
94termination of RNA polymerase I transcription (GO:0006363)2.70139818
95GTP biosynthetic process (GO:0006183)2.69615538
96ncRNA metabolic process (GO:0034660)2.69320852
97purine nucleobase biosynthetic process (GO:0009113)2.68921322
98ncRNA processing (GO:0034470)2.68412821
99nucleobase biosynthetic process (GO:0046112)2.66640535
100somatic diversification of immunoglobulins (GO:0016445)2.65870897

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.43434208
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.27755978
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.90039644
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.64014800
5VDR_22108803_ChIP-Seq_LS180_Human2.95007973
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.94049732
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.91005371
8E2F7_22180533_ChIP-Seq_HELA_Human2.70432700
9VDR_23849224_ChIP-Seq_CD4+_Human2.70164198
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.60618026
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.55561253
12ZNF274_21170338_ChIP-Seq_K562_Hela2.55243011
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.45333212
14ELK1_19687146_ChIP-ChIP_HELA_Human2.44054149
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.40260598
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.18698718
17MYC_18555785_ChIP-Seq_MESCs_Mouse2.18469783
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.17956409
19FOXP3_21729870_ChIP-Seq_TREG_Human2.17722058
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.16218328
21SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.12352665
22MYC_18940864_ChIP-ChIP_HL60_Human2.05431327
23EWS_26573619_Chip-Seq_HEK293_Human2.04254446
24NOTCH1_21737748_ChIP-Seq_TLL_Human2.02380645
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.95912449
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.94711366
27PADI4_21655091_ChIP-ChIP_MCF-7_Human1.89459302
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.85052408
29FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.83130714
30SRF_21415370_ChIP-Seq_HL-1_Mouse1.81807393
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76217646
32IGF1R_20145208_ChIP-Seq_DFB_Human1.73194120
33PCGF2_27294783_Chip-Seq_NPCs_Mouse1.68218816
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.66016378
35FUS_26573619_Chip-Seq_HEK293_Human1.64965687
36CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.60783745
37TP53_22573176_ChIP-Seq_HFKS_Human1.56962154
38TAF15_26573619_Chip-Seq_HEK293_Human1.56824398
39PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.56695323
40MYC_19030024_ChIP-ChIP_MESCs_Mouse1.53442429
41MYC_18358816_ChIP-ChIP_MESCs_Mouse1.46306365
42FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.45814853
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.45623757
44GABP_19822575_ChIP-Seq_HepG2_Human1.39072516
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.36644639
46ZFP57_27257070_Chip-Seq_ESCs_Mouse1.34909556
47POU3F2_20337985_ChIP-ChIP_501MEL_Human1.34543343
48P300_19829295_ChIP-Seq_ESCs_Human1.33118249
49POU5F1_16153702_ChIP-ChIP_HESCs_Human1.32949017
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30816179
51IRF1_19129219_ChIP-ChIP_H3396_Human1.30613933
52DCP1A_22483619_ChIP-Seq_HELA_Human1.29057450
53TTF2_22483619_ChIP-Seq_HELA_Human1.27528947
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27413868
55YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24872175
56SALL1_21062744_ChIP-ChIP_HESCs_Human1.24317508
57FOXA1_27270436_Chip-Seq_PROSTATE_Human1.23003811
58FOXA1_25329375_ChIP-Seq_VCAP_Human1.23003811
59MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20353508
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20006103
61E2F1_18555785_ChIP-Seq_MESCs_Mouse1.18974287
62NFE2_27457419_Chip-Seq_LIVER_Mouse1.18914737
63NANOG_19829295_ChIP-Seq_ESCs_Human1.14677268
64SOX2_19829295_ChIP-Seq_ESCs_Human1.14677268
65POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.13459470
66GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12720841
67KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.12366303
68IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.10857588
69AR_20517297_ChIP-Seq_VCAP_Human1.10575348
70EZH2_27294783_Chip-Seq_NPCs_Mouse1.10096552
71YY1_21170310_ChIP-Seq_MESCs_Mouse1.08430500
72CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08260320
73AUTS2_25519132_ChIP-Seq_293T-REX_Human1.06591920
74GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.06412012
75ER_23166858_ChIP-Seq_MCF-7_Human1.05358532
76MYC_19079543_ChIP-ChIP_MESCs_Mouse1.03852132
77HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.03290411
78RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01418671
79ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.01061366
80CBP_20019798_ChIP-Seq_JUKART_Human1.00885341
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.00885341
82ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99774654
83HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.99202715
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99030791
85MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.98369961
86EGR1_23403033_ChIP-Seq_LIVER_Mouse0.96973994
87GATA3_26560356_Chip-Seq_TH2_Human0.96692834
88NCOR_22424771_ChIP-Seq_293T_Human0.94737456
89E2F1_21310950_ChIP-Seq_MCF-7_Human0.94165384
90HOXB7_26014856_ChIP-Seq_BT474_Human0.92883810
91CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.92416229
92KLF5_20875108_ChIP-Seq_MESCs_Mouse0.92352943
93BCAT_22108803_ChIP-Seq_LS180_Human0.91969857
94EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.91531931
95CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.90783611
96XRN2_22483619_ChIP-Seq_HELA_Human0.90570041
97THAP11_20581084_ChIP-Seq_MESCs_Mouse0.89722339
98TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89707379
99ELK1_22589737_ChIP-Seq_MCF10A_Human0.89062779
100SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.87936396

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.92636852
2MP0008877_abnormal_DNA_methylation3.81469978
3MP0002102_abnormal_ear_morphology3.47479927
4MP0008058_abnormal_DNA_repair2.67252589
5MP0006072_abnormal_retinal_apoptosis2.66645676
6MP0010094_abnormal_chromosome_stability2.66109810
7MP0002138_abnormal_hepatobiliary_system2.25949458
8MP0002938_white_spotting2.21110364
9MP0003693_abnormal_embryo_hatching2.12438671
10MP0008789_abnormal_olfactory_epithelium2.08916717
11MP0008872_abnormal_physiological_respon2.08659857
12MP0008875_abnormal_xenobiotic_pharmacok2.07407894
13MP0003786_premature_aging2.02914460
14MP0004147_increased_porphyrin_level2.02223044
15MP0005671_abnormal_response_to2.02166568
16MP0003806_abnormal_nucleotide_metabolis1.94944332
17MP0003787_abnormal_imprinting1.91980144
18MP0003567_abnormal_fetal_cardiomyocyte1.88739999
19MP0003718_maternal_effect1.82609549
20MP0000372_irregular_coat_pigmentation1.77481938
21MP0005646_abnormal_pituitary_gland1.76043821
22MP0005645_abnormal_hypothalamus_physiol1.71547742
23MP0005551_abnormal_eye_electrophysiolog1.70502413
24MP0001835_abnormal_antigen_presentation1.65148147
25MP0005253_abnormal_eye_physiology1.60890180
26MP0009697_abnormal_copulation1.60865922
27MP0005075_abnormal_melanosome_morpholog1.60792326
28MP0001764_abnormal_homeostasis1.59828771
29MP0002736_abnormal_nociception_after1.57151654
30MP0004957_abnormal_blastocyst_morpholog1.57147586
31MP0006036_abnormal_mitochondrial_physio1.52429888
32MP0001968_abnormal_touch/_nociception1.51792157
33MP0003195_calcinosis1.50677303
34MP0008057_abnormal_DNA_replication1.49221030
35MP0002160_abnormal_reproductive_system1.47757377
36MP0005394_taste/olfaction_phenotype1.45631677
37MP0005499_abnormal_olfactory_system1.45631677
38MP0002638_abnormal_pupillary_reflex1.42508965
39MP0003646_muscle_fatigue1.40829738
40MP0002837_dystrophic_cardiac_calcinosis1.35960233
41MP0001293_anophthalmia1.35516432
42MP0005084_abnormal_gallbladder_morpholo1.33132000
43MP0000569_abnormal_digit_pigmentation1.31561982
44MP0008995_early_reproductive_senescence1.30532628
45MP0005085_abnormal_gallbladder_physiolo1.28730096
46MP0005389_reproductive_system_phenotype1.28091705
47MP0001873_stomach_inflammation1.23664741
48MP0002876_abnormal_thyroid_physiology1.22807591
49MP0003111_abnormal_nucleus_morphology1.22329345
50MP0006035_abnormal_mitochondrial_morpho1.19025579
51MP0004885_abnormal_endolymph1.18847421
52MP0003186_abnormal_redox_activity1.17559114
53MP0005377_hearing/vestibular/ear_phenot1.16699827
54MP0003878_abnormal_ear_physiology1.16699827
55MP0001919_abnormal_reproductive_system1.12710418
56MP0004145_abnormal_muscle_electrophysio1.10474179
57MP0002210_abnormal_sex_determination1.06767919
58MP0001984_abnormal_olfaction1.05763901
59MP0001661_extended_life_span1.05559825
60MP0002006_tumorigenesis1.03567297
61MP0003077_abnormal_cell_cycle1.02642923
62MP0005360_urolithiasis1.01826366
63MP0000383_abnormal_hair_follicle0.98562278
64MP0001929_abnormal_gametogenesis0.97757870
65MP0008007_abnormal_cellular_replicative0.93978869
66MP0000613_abnormal_salivary_gland0.92657673
67MP0009333_abnormal_splenocyte_physiolog0.92173539
68MP0000653_abnormal_sex_gland0.92035287
69MP0002148_abnormal_hypersensitivity_rea0.89785977
70MP0001119_abnormal_female_reproductive0.89784048
71MP0002163_abnormal_gland_morphology0.89775561
72MP0000647_abnormal_sebaceous_gland0.89238289
73MP0001145_abnormal_male_reproductive0.88824771
74MP0005410_abnormal_fertilization0.88789779
75MP0001529_abnormal_vocalization0.88019544
76MP0002166_altered_tumor_susceptibility0.85556602
77MP0004142_abnormal_muscle_tone0.83454017
78MP0003011_delayed_dark_adaptation0.83409689
79MP0002095_abnormal_skin_pigmentation0.83236735
80MP0002234_abnormal_pharynx_morphology0.79928173
81MP0002272_abnormal_nervous_system0.79256904
82MP0004043_abnormal_pH_regulation0.79037701
83MP0003121_genomic_imprinting0.78685882
84MP0001188_hyperpigmentation0.78391177
85MP0003937_abnormal_limbs/digits/tail_de0.78134102
86MP0006276_abnormal_autonomic_nervous0.76050078
87MP0005379_endocrine/exocrine_gland_phen0.75710823
88MP0003119_abnormal_digestive_system0.75542737
89MP0003252_abnormal_bile_duct0.75234212
90MP0000631_abnormal_neuroendocrine_gland0.74533625
91MP0000685_abnormal_immune_system0.73989093
92MP0005195_abnormal_posterior_eye0.73764852
93MP0005332_abnormal_amino_acid0.73513431
94MP0001485_abnormal_pinna_reflex0.73483814
95MP0005391_vision/eye_phenotype0.73469199
96MP0001800_abnormal_humoral_immune0.72467665
97MP0010386_abnormal_urinary_bladder0.72352324
98MP0004133_heterotaxia0.71678634
99MP0001501_abnormal_sleep_pattern0.71442154
100MP0002751_abnormal_autonomic_nervous0.70224092

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)3.71246118
2Increased CSF lactate (HP:0002490)3.53047336
3Mitochondrial inheritance (HP:0001427)3.50282568
4Acute encephalopathy (HP:0006846)3.39325128
5Pancreatic cysts (HP:0001737)3.34563952
6Abnormality of alanine metabolism (HP:0010916)3.33255667
7Hyperalaninemia (HP:0003348)3.33255667
8Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.33255667
9Abnormal mitochondria in muscle tissue (HP:0008316)3.08400574
10IgG deficiency (HP:0004315)3.05458700
11Progressive macrocephaly (HP:0004481)3.04425709
12Methylmalonic acidemia (HP:0002912)3.03235078
13Molar tooth sign on MRI (HP:0002419)2.92909530
14Abnormality of midbrain morphology (HP:0002418)2.92909530
15Pancreatic fibrosis (HP:0100732)2.91525713
16Severe combined immunodeficiency (HP:0004430)2.90917281
17True hermaphroditism (HP:0010459)2.88445984
18Hepatocellular necrosis (HP:0001404)2.88304621
19Increased serum lactate (HP:0002151)2.84956383
20Constricted visual fields (HP:0001133)2.82028510
21Methylmalonic aciduria (HP:0012120)2.79089981
22Hepatic necrosis (HP:0002605)2.77912121
23Abnormality of B cell number (HP:0010975)2.74527784
24Increased hepatocellular lipid droplets (HP:0006565)2.74416698
25Absent rod-and cone-mediated responses on ERG (HP:0007688)2.73444170
26Renal cortical cysts (HP:0000803)2.69385180
27B lymphocytopenia (HP:0010976)2.68998818
28Cerebral edema (HP:0002181)2.68145799
29Congenital stationary night blindness (HP:0007642)2.59670237
30Abolished electroretinogram (ERG) (HP:0000550)2.59465888
31Nephronophthisis (HP:0000090)2.56689782
32Lipid accumulation in hepatocytes (HP:0006561)2.56270536
33Colon cancer (HP:0003003)2.53097728
34Abnormality of the renal cortex (HP:0011035)2.49955772
35Abnormality of serum amino acid levels (HP:0003112)2.49245708
36Aplasia/Hypoplasia of the fovea (HP:0008060)2.48986501
37Hypoplasia of the fovea (HP:0007750)2.48986501
38Pendular nystagmus (HP:0012043)2.47203080
39Abnormality of the labia minora (HP:0012880)2.47142665
40Thyroiditis (HP:0100646)2.45773033
41Optic disc pallor (HP:0000543)2.44691207
42Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.40892002
43Hypoproteinemia (HP:0003075)2.38413147
44Abnormal rod and cone electroretinograms (HP:0008323)2.38399191
45Volvulus (HP:0002580)2.37956507
46Decreased electroretinogram (ERG) amplitude (HP:0000654)2.36567744
47Lactic acidosis (HP:0003128)2.33297313
48Stomatitis (HP:0010280)2.32570508
49Combined immunodeficiency (HP:0005387)2.29953678
50Hyperglycinemia (HP:0002154)2.24326619
51Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.23721455
52Abnormality of the pons (HP:0007361)2.22701156
53Meckel diverticulum (HP:0002245)2.22659468
54Attenuation of retinal blood vessels (HP:0007843)2.22249418
55Abnormality of aspartate family amino acid metabolism (HP:0010899)2.21650006
563-Methylglutaconic aciduria (HP:0003535)2.19420454
57Abnormality of the ileum (HP:0001549)2.18307403
58Abnormality of the fovea (HP:0000493)2.15569414
59Hyperglycinuria (HP:0003108)2.12353382
60Aplasia/Hypoplasia of the uvula (HP:0010293)2.09929009
61Abnormality of the renal collecting system (HP:0004742)2.08956549
62Congenital, generalized hypertrichosis (HP:0004540)2.07561576
63Lethargy (HP:0001254)2.02647988
64Hypoplasia of the pons (HP:0012110)2.02346066
65Abnormality of glycine metabolism (HP:0010895)2.01740115
66Abnormality of serine family amino acid metabolism (HP:0010894)2.01740115
67Abnormality of the renal medulla (HP:0100957)2.00569683
68Duplicated collecting system (HP:0000081)2.00482003
69Abnormality of the prostate (HP:0008775)1.97452288
70Leukodystrophy (HP:0002415)1.96829033
71Supernumerary spleens (HP:0009799)1.96686520
72Abnormal biliary tract physiology (HP:0012439)1.94546987
73Bile duct proliferation (HP:0001408)1.94546987
74Horseshoe kidney (HP:0000085)1.94051129
75Chromsome breakage (HP:0040012)1.93951935
76Renal Fanconi syndrome (HP:0001994)1.92860956
77Abnormality of DNA repair (HP:0003254)1.89026586
78Abnormality of the vitamin B12 metabolism (HP:0004341)1.87636120
79Aplasia/hypoplasia of the uterus (HP:0008684)1.86789085
80Generalized aminoaciduria (HP:0002909)1.85768583
81Abnormality of chromosome stability (HP:0003220)1.84547593
82Chromosomal breakage induced by crosslinking agents (HP:0003221)1.83850223
83Abnormality of vitamin B metabolism (HP:0004340)1.83032547
84Respiratory failure (HP:0002878)1.80968980
85Abnormality of methionine metabolism (HP:0010901)1.80009492
86Abnormality of urine glucose concentration (HP:0011016)1.79376616
87Glycosuria (HP:0003076)1.79376616
88Aplasia/Hypoplasia of the spleen (HP:0010451)1.78684322
89Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.78238126
90Exercise intolerance (HP:0003546)1.78098764
91Decreased central vision (HP:0007663)1.77224727
92Abnormality of eosinophils (HP:0001879)1.76952368
93Poor head control (HP:0002421)1.75463840
94Progressive microcephaly (HP:0000253)1.74691396
95Carpal bone hypoplasia (HP:0001498)1.73590253
96Abnormal protein N-linked glycosylation (HP:0012347)1.72355767
97Abnormal protein glycosylation (HP:0012346)1.72355767
98Abnormal glycosylation (HP:0012345)1.72355767
99Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.72355767
100Chronic hepatic failure (HP:0100626)1.72075203

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.67487521
2ZAK3.29088140
3EIF2AK33.14767113
4NEK12.84380583
5MAP4K22.84211700
6TSSK62.70202181
7NUAK12.48903082
8BUB12.47270375
9TLK12.34210845
10SRPK12.31859708
11STK162.30125378
12TRIM282.20821525
13VRK12.19839679
14MST42.14587731
15GRK12.04559500
16MKNK21.98573980
17TXK1.97880174
18TAF11.89182874
19ADRBK21.82728889
20FRK1.80938787
21PLK31.80333124
22BMPR1B1.77428045
23WNK31.75749039
24EIF2AK11.75060679
25MKNK11.65506599
26PLK41.60018937
27WNK41.43344101
28PBK1.41421860
29TAOK31.31368724
30STK391.26083173
31OXSR11.24028234
32CDC71.23264578
33EIF2AK21.21306375
34PLK21.18118598
35BCKDK1.14565268
36MAPK131.12522694
37CSNK1G11.01933683
38ACVR1B1.00636166
39CDK190.99723987
40CSNK1G30.95784530
41TTK0.95136200
42ATR0.94197844
43STK38L0.92312188
44TGFBR10.88778139
45PDK20.87492752
46TEC0.86262175
47CSNK1G20.84988830
48CSNK1A1L0.83698000
49DYRK20.80655474
50DAPK10.79438702
51NME10.78453981
52INSRR0.78372108
53CDK80.76861275
54KDR0.76711029
55PLK10.76137670
56WEE10.69957461
57TNIK0.66592974
58PIK3CG0.64614817
59TIE10.64055233
60PHKG10.63996795
61PHKG20.63996795
62AURKB0.63898573
63RPS6KA50.62152809
64RPS6KA40.61025705
65PASK0.58873587
66ERBB30.58649583
67CDK90.56889627
68MAP3K40.55604025
69ITK0.54249103
70CASK0.53992875
71BRSK20.52273020
72MAPKAPK50.49987243
73PRKCE0.49845722
74MAPKAPK30.48480993
75PRKCG0.47998412
76CHEK20.46460555
77ADRBK10.46359209
78ATM0.45687350
79BCR0.45438609
80CSNK2A20.44910088
81ALK0.44888592
82CDK70.42586909
83CSNK2A10.42522395
84CSNK1A10.40336071
85STK30.39023391
86PRKCQ0.38700684
87CCNB10.37636505
88CSNK1E0.36499072
89RPS6KB20.36333208
90AURKA0.33921293
91IKBKB0.33905206
92MAP3K120.33546209
93GRK50.33213696
94DAPK30.32184362
95TESK20.31759622
96PAK30.28785655
97PTK2B0.28717952
98CSNK1D0.26749028
99NEK20.26700293
100CHEK10.25537475

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.27607989
2Protein export_Homo sapiens_hsa030602.98739825
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.77356612
4RNA polymerase_Homo sapiens_hsa030202.57764194
5One carbon pool by folate_Homo sapiens_hsa006702.52258316
6Oxidative phosphorylation_Homo sapiens_hsa001902.31256427
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.12153071
8Homologous recombination_Homo sapiens_hsa034402.07050092
9Mismatch repair_Homo sapiens_hsa034302.06018456
10Ribosome_Homo sapiens_hsa030101.94859096
11RNA transport_Homo sapiens_hsa030131.94850436
12Non-homologous end-joining_Homo sapiens_hsa034501.94813909
13DNA replication_Homo sapiens_hsa030301.94708379
14Basal transcription factors_Homo sapiens_hsa030221.92759088
15Asthma_Homo sapiens_hsa053101.92398298
16Parkinsons disease_Homo sapiens_hsa050121.86261651
17RNA degradation_Homo sapiens_hsa030181.84249022
18Primary immunodeficiency_Homo sapiens_hsa053401.82441462
19Fanconi anemia pathway_Homo sapiens_hsa034601.80719007
20Propanoate metabolism_Homo sapiens_hsa006401.76349742
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.66667979
22Spliceosome_Homo sapiens_hsa030401.64846118
23Allograft rejection_Homo sapiens_hsa053301.62407139
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.62355339
25Nucleotide excision repair_Homo sapiens_hsa034201.59315971
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.52417833
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.49700496
28Autoimmune thyroid disease_Homo sapiens_hsa053201.47702255
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.41250914
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.39194269
31Base excision repair_Homo sapiens_hsa034101.36752878
32Butanoate metabolism_Homo sapiens_hsa006501.35702960
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.34462554
34Pyrimidine metabolism_Homo sapiens_hsa002401.29639330
35Type I diabetes mellitus_Homo sapiens_hsa049401.28554522
36Huntingtons disease_Homo sapiens_hsa050161.28197065
37Caffeine metabolism_Homo sapiens_hsa002321.26448986
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.24811333
39Phototransduction_Homo sapiens_hsa047441.19258261
40Nitrogen metabolism_Homo sapiens_hsa009101.19191517
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.18429936
42Purine metabolism_Homo sapiens_hsa002301.17942995
43Peroxisome_Homo sapiens_hsa041461.16687539
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.11912190
45Graft-versus-host disease_Homo sapiens_hsa053321.10558107
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.10258071
47Linoleic acid metabolism_Homo sapiens_hsa005911.08971809
48Selenocompound metabolism_Homo sapiens_hsa004501.06621623
49Sulfur metabolism_Homo sapiens_hsa009201.05604164
50Sulfur relay system_Homo sapiens_hsa041221.03871789
51Systemic lupus erythematosus_Homo sapiens_hsa053221.03567791
52Alzheimers disease_Homo sapiens_hsa050101.00424413
53Primary bile acid biosynthesis_Homo sapiens_hsa001200.83853421
54Vitamin B6 metabolism_Homo sapiens_hsa007500.82682349
55alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.82570023
56Tryptophan metabolism_Homo sapiens_hsa003800.81244566
57Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.76666372
58Regulation of autophagy_Homo sapiens_hsa041400.76016032
59Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.74959216
60Antigen processing and presentation_Homo sapiens_hsa046120.73221651
61Rheumatoid arthritis_Homo sapiens_hsa053230.73121250
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71281653
63Steroid biosynthesis_Homo sapiens_hsa001000.71217926
64Retinol metabolism_Homo sapiens_hsa008300.70499238
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.69322684
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.69254321
67Fatty acid elongation_Homo sapiens_hsa000620.66305161
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66220960
69Glutathione metabolism_Homo sapiens_hsa004800.65244836
70Metabolic pathways_Homo sapiens_hsa011000.64784150
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.64781036
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64720028
73Collecting duct acid secretion_Homo sapiens_hsa049660.62219024
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60640918
75Ether lipid metabolism_Homo sapiens_hsa005650.60620908
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60073156
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58648622
78Chemical carcinogenesis_Homo sapiens_hsa052040.57211634
79Hematopoietic cell lineage_Homo sapiens_hsa046400.56932728
80Arginine biosynthesis_Homo sapiens_hsa002200.55992393
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54798929
82Folate biosynthesis_Homo sapiens_hsa007900.54307974
83Pyruvate metabolism_Homo sapiens_hsa006200.52949360
84beta-Alanine metabolism_Homo sapiens_hsa004100.52697962
85Arachidonic acid metabolism_Homo sapiens_hsa005900.52133449
86mRNA surveillance pathway_Homo sapiens_hsa030150.50003274
87Cell cycle_Homo sapiens_hsa041100.49107191
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.47693505
89Nicotine addiction_Homo sapiens_hsa050330.46578351
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43655901
91Cardiac muscle contraction_Homo sapiens_hsa042600.42667008
92Carbon metabolism_Homo sapiens_hsa012000.42651313
93Olfactory transduction_Homo sapiens_hsa047400.42398956
94Fat digestion and absorption_Homo sapiens_hsa049750.42112324
952-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.38815185
96Vitamin digestion and absorption_Homo sapiens_hsa049770.38684766
97Fatty acid degradation_Homo sapiens_hsa000710.37121188
98Arginine and proline metabolism_Homo sapiens_hsa003300.36248942
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35338686
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.33932263

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