NPM1P26

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1water-soluble vitamin biosynthetic process (GO:0042364)4.43822334
2maturation of 5.8S rRNA (GO:0000460)4.40619433
3positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.36480366
4proteasome assembly (GO:0043248)4.35656787
5regulation of centriole replication (GO:0046599)4.22832516
6regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)4.21586581
7regulation of chronic inflammatory response (GO:0002676)3.92706486
8DNA deamination (GO:0045006)3.92077507
9regulation of isotype switching to IgG isotypes (GO:0048302)3.77082983
10rRNA modification (GO:0000154)3.63684344
11ribosome assembly (GO:0042255)3.63454095
12rRNA catabolic process (GO:0016075)3.61977571
13protein polyglutamylation (GO:0018095)3.56360441
14RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.53793626
15nuclear pore complex assembly (GO:0051292)3.48558582
16pseudouridine synthesis (GO:0001522)3.37103782
17nuclear pore organization (GO:0006999)3.33486964
18regulation of immunoglobulin secretion (GO:0051023)3.32513669
19exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.30664589
20neural tube formation (GO:0001841)3.29962665
21nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.17872676
22establishment of protein localization to mitochondrial membrane (GO:0090151)3.16374790
23ribosomal large subunit biogenesis (GO:0042273)3.13967550
24rRNA methylation (GO:0031167)3.11246990
25mitochondrial respiratory chain complex I assembly (GO:0032981)3.09759002
26NADH dehydrogenase complex assembly (GO:0010257)3.09759002
27mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.09759002
28double-strand break repair via homologous recombination (GO:0000724)3.07625134
29positive regulation of isotype switching (GO:0045830)3.04845564
30somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.03904634
31somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.03904634
32isotype switching (GO:0045190)3.03904634
33transcription elongation from RNA polymerase III promoter (GO:0006385)3.03184920
34termination of RNA polymerase III transcription (GO:0006386)3.03184920
35recombinational repair (GO:0000725)3.02277132
36rRNA processing (GO:0006364)2.98538414
37monoubiquitinated protein deubiquitination (GO:0035520)2.98334699
38protein K11-linked deubiquitination (GO:0035871)2.98133046
39mitochondrial respiratory chain complex assembly (GO:0033108)2.96126821
40DNA demethylation (GO:0080111)2.94528138
41GTP biosynthetic process (GO:0006183)2.94217143
42rRNA metabolic process (GO:0016072)2.92714308
43cullin deneddylation (GO:0010388)2.92272039
44positive regulation of granulocyte differentiation (GO:0030854)2.90240829
45embryonic hemopoiesis (GO:0035162)2.90103190
46CENP-A containing nucleosome assembly (GO:0034080)2.88396507
47chromatin remodeling at centromere (GO:0031055)2.87262011
48intracellular protein transmembrane import (GO:0044743)2.86728084
49histone mRNA metabolic process (GO:0008334)2.86218571
50regulation of regulatory T cell differentiation (GO:0045589)2.85906918
51negative regulation of DNA-dependent DNA replication (GO:2000104)2.85796387
52transcription from mitochondrial promoter (GO:0006390)2.84462519
53positive regulation of DNA recombination (GO:0045911)2.83942692
54detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.82619376
55histone mRNA catabolic process (GO:0071044)2.81622124
56spliceosomal complex assembly (GO:0000245)2.79986224
57DNA-dependent DNA replication (GO:0006261)2.79499453
58keratinocyte development (GO:0003334)2.77474515
59mitochondrial RNA metabolic process (GO:0000959)2.76832943
60regulation of nuclear cell cycle DNA replication (GO:0033262)2.76604222
61regulation of DNA endoreduplication (GO:0032875)2.74308343
62transcription elongation from RNA polymerase I promoter (GO:0006362)2.74161238
63UTP biosynthetic process (GO:0006228)2.72773707
64regulation of centrosome duplication (GO:0010824)2.71599237
65spliceosomal snRNP assembly (GO:0000387)2.67394604
66alpha-beta T cell differentiation (GO:0046632)2.66843405
67termination of RNA polymerase I transcription (GO:0006363)2.65202890
68DNA replication checkpoint (GO:0000076)2.64920303
69telomere maintenance via telomerase (GO:0007004)2.62932574
70definitive hemopoiesis (GO:0060216)2.62754121
71ribosome biogenesis (GO:0042254)2.62461421
72protein K63-linked deubiquitination (GO:0070536)2.61659801
73estrogen biosynthetic process (GO:0006703)2.58441665
74pore complex assembly (GO:0046931)2.58318884
75UTP metabolic process (GO:0046051)2.57605148
76behavioral response to nicotine (GO:0035095)2.57495808
77tRNA processing (GO:0008033)2.56023543
78histone exchange (GO:0043486)2.55902129
79DNA dealkylation (GO:0035510)2.55193427
80ncRNA catabolic process (GO:0034661)2.54711839
81ribonucleoprotein complex biogenesis (GO:0022613)2.53577386
82organelle disassembly (GO:1903008)2.53036796
83protein deneddylation (GO:0000338)2.52376639
84ncRNA metabolic process (GO:0034660)2.51420690
85regulation of centrosome cycle (GO:0046605)2.51098919
86negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.50698372
87negative regulation of T-helper cell differentiation (GO:0045623)2.50698372
88tRNA metabolic process (GO:0006399)2.49479540
89transcription initiation from RNA polymerase I promoter (GO:0006361)2.48250231
90viral mRNA export from host cell nucleus (GO:0046784)2.47422595
91somatic recombination of immunoglobulin gene segments (GO:0016447)2.46116813
92CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.45338348
93T-helper cell differentiation (GO:0042093)2.45338348
94IMP metabolic process (GO:0046040)2.44944493
95protein complex biogenesis (GO:0070271)2.44583963
96ncRNA processing (GO:0034470)2.44315939
97prenylation (GO:0097354)2.44273533
98protein prenylation (GO:0018342)2.44273533
99CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.44042670
100replicative senescence (GO:0090399)2.43827204

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.59082942
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.79084818
3VDR_22108803_ChIP-Seq_LS180_Human3.38628644
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.32329266
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.16879965
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.04984798
7NOTCH1_21737748_ChIP-Seq_TLL_Human2.63517374
8ZNF274_21170338_ChIP-Seq_K562_Hela2.58422738
9EWS_26573619_Chip-Seq_HEK293_Human2.55418285
10VDR_23849224_ChIP-Seq_CD4+_Human2.55093211
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.48242077
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.41327570
13GATA1_22025678_ChIP-Seq_K562_Human2.41276694
14ELK1_19687146_ChIP-ChIP_HELA_Human2.38469671
15TAF15_26573619_Chip-Seq_HEK293_Human2.36459479
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.28939379
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.18076980
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.16102201
19E2F7_22180533_ChIP-Seq_HELA_Human2.08576492
20FUS_26573619_Chip-Seq_HEK293_Human2.01794600
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.96180769
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.95866327
23PADI4_21655091_ChIP-ChIP_MCF-7_Human1.93032852
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.92329658
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.91691986
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.87807185
27FOXP3_21729870_ChIP-Seq_TREG_Human1.83965296
28ETS1_20019798_ChIP-Seq_JURKAT_Human1.82273120
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.80397187
30FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.77101351
31PCGF2_27294783_Chip-Seq_NPCs_Mouse1.74854227
32FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.73914532
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.71820938
34JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.70395604
35KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.70045115
36IGF1R_20145208_ChIP-Seq_DFB_Human1.65596377
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.65214585
38MYC_18555785_ChIP-Seq_MESCs_Mouse1.63528338
39BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.61206684
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.52878679
41MYC_18940864_ChIP-ChIP_HL60_Human1.49644807
42YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48331181
43ER_23166858_ChIP-Seq_MCF-7_Human1.47044760
44P300_19829295_ChIP-Seq_ESCs_Human1.46512237
45EZH2_27294783_Chip-Seq_NPCs_Mouse1.36480777
46SUZ12_27294783_Chip-Seq_NPCs_Mouse1.34334643
47DCP1A_22483619_ChIP-Seq_HELA_Human1.33835117
48AUTS2_25519132_ChIP-Seq_293T-REX_Human1.32753785
49CREB1_15753290_ChIP-ChIP_HEK293T_Human1.31809024
50UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24613538
51NFE2_27457419_Chip-Seq_LIVER_Mouse1.23638966
52GATA3_26560356_Chip-Seq_TH2_Human1.21355504
53TTF2_22483619_ChIP-Seq_HELA_Human1.20784019
54AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20490939
55MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.18062839
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16553221
57CBP_20019798_ChIP-Seq_JUKART_Human1.16553221
58STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.15792897
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.14337230
60MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14226960
61GBX2_23144817_ChIP-Seq_PC3_Human1.14166689
62IRF1_19129219_ChIP-ChIP_H3396_Human1.14109929
63HOXB4_20404135_ChIP-ChIP_EML_Mouse1.11550913
64NANOG_18555785_Chip-Seq_ESCs_Mouse1.11357780
65CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11213795
66OCT4_18555785_Chip-Seq_ESCs_Mouse1.09571855
67MYC_19030024_ChIP-ChIP_MESCs_Mouse1.08434090
68TP53_22573176_ChIP-Seq_HFKS_Human1.07994185
69E2F1_18555785_Chip-Seq_ESCs_Mouse1.07533091
70TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07127024
71CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05838298
72SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04436795
73E2F1_21310950_ChIP-Seq_MCF-7_Human1.04047066
74P300_18555785_Chip-Seq_ESCs_Mouse1.03978830
75CRX_20693478_ChIP-Seq_RETINA_Mouse1.03783089
76SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.00814227
77SRF_21415370_ChIP-Seq_HL-1_Mouse1.00128991
78NANOG_19829295_ChIP-Seq_ESCs_Human0.99894823
79SOX2_19829295_ChIP-Seq_ESCs_Human0.99894823
80EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99821345
81CTBP2_25329375_ChIP-Seq_LNCAP_Human0.98674756
82RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.97398990
83P53_22387025_ChIP-Seq_ESCs_Mouse0.97258706
84CMYC_18555785_Chip-Seq_ESCs_Mouse0.96782924
85EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96384368
86SMAD3_21741376_ChIP-Seq_EPCs_Human0.96222454
87OCT4_21477851_ChIP-Seq_ESCs_Mouse0.95964932
88GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95430323
89STAT3_18555785_Chip-Seq_ESCs_Mouse0.94286453
90STAT3_23295773_ChIP-Seq_U87_Human0.93889116
91GABP_19822575_ChIP-Seq_HepG2_Human0.93827917
92TCF4_23295773_ChIP-Seq_U87_Human0.92130848
93SOX2_18555785_Chip-Seq_ESCs_Mouse0.92092372
94RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.91238306
95CDX2_22108803_ChIP-Seq_LS180_Human0.90310711
96KLF5_20875108_ChIP-Seq_MESCs_Mouse0.89612960
97TCF4_22108803_ChIP-Seq_LS180_Human0.89597169
98ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.88720631
99SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.87786565
100FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.87770903

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.47850952
2MP0000569_abnormal_digit_pigmentation2.85955644
3MP0003786_premature_aging2.58631569
4MP0010094_abnormal_chromosome_stability2.46056336
5MP0008058_abnormal_DNA_repair2.39263629
6MP0009697_abnormal_copulation2.30271610
7MP0001835_abnormal_antigen_presentation2.27432136
8MP0002009_preneoplasia2.21615968
9MP0005408_hypopigmentation2.14846031
10MP0005310_abnormal_salivary_gland2.03813444
11MP0004957_abnormal_blastocyst_morpholog2.02491218
12MP0006035_abnormal_mitochondrial_morpho1.96497382
13MP0003763_abnormal_thymus_physiology1.89855339
14MP0008877_abnormal_DNA_methylation1.89570129
15MP0000685_abnormal_immune_system1.83706539
16MP0006072_abnormal_retinal_apoptosis1.81755162
17MP0003077_abnormal_cell_cycle1.81718423
18MP0003718_maternal_effect1.75900087
19MP0003221_abnormal_cardiomyocyte_apopto1.75136428
20MP0002837_dystrophic_cardiac_calcinosis1.73558862
21MP0008875_abnormal_xenobiotic_pharmacok1.72006730
22MP0004147_increased_porphyrin_level1.71889230
23MP0003693_abnormal_embryo_hatching1.66538684
24MP0003567_abnormal_fetal_cardiomyocyte1.65059068
25MP0003195_calcinosis1.64281015
26MP0002166_altered_tumor_susceptibility1.61559809
27MP0000465_gastrointestinal_hemorrhage1.60026144
28MP0001873_stomach_inflammation1.56390133
29MP0005646_abnormal_pituitary_gland1.53719519
30MP0005645_abnormal_hypothalamus_physiol1.50965766
31MP0002006_tumorigenesis1.45605061
32MP0004808_abnormal_hematopoietic_stem1.45096283
33MP0002102_abnormal_ear_morphology1.43865162
34MP0008995_early_reproductive_senescence1.43802073
35MP0000427_abnormal_hair_cycle1.43728206
36MP0002138_abnormal_hepatobiliary_system1.43030213
37MP0001529_abnormal_vocalization1.41719255
38MP0003045_fibrosis1.37698602
39MP0001853_heart_inflammation1.37006188
40MP0008007_abnormal_cellular_replicative1.34477425
41MP0005253_abnormal_eye_physiology1.34010356
42MP0008789_abnormal_olfactory_epithelium1.30177042
43MP0005551_abnormal_eye_electrophysiolog1.27847002
44MP0008872_abnormal_physiological_respon1.27755289
45MP0002396_abnormal_hematopoietic_system1.27644878
46MP0008961_abnormal_basal_metabolism1.25668444
47MP0001501_abnormal_sleep_pattern1.25329106
48MP0006276_abnormal_autonomic_nervous1.23950296
49MP0002928_abnormal_bile_duct1.21053855
50MP0004145_abnormal_muscle_electrophysio1.20004354
51MP0004142_abnormal_muscle_tone1.16468992
52MP0004782_abnormal_surfactant_physiolog1.15288866
53MP0005389_reproductive_system_phenotype1.14790937
54MP0003880_abnormal_central_pattern1.11521145
55MP0005075_abnormal_melanosome_morpholog1.11387610
56MP0004133_heterotaxia1.10963116
57MP0000383_abnormal_hair_follicle1.10953441
58MP0002398_abnormal_bone_marrow1.07657261
59MP0002638_abnormal_pupillary_reflex1.05356668
60MP0000703_abnormal_thymus_morphology1.05030564
61MP0001119_abnormal_female_reproductive1.01740805
62MP0003646_muscle_fatigue0.99891142
63MP0003186_abnormal_redox_activity0.99865704
64MP0002160_abnormal_reproductive_system0.99431908
65MP0003890_abnormal_embryonic-extraembry0.98936873
66MP0001800_abnormal_humoral_immune0.96659986
67MP0000371_diluted_coat_color0.96046208
68MP0000689_abnormal_spleen_morphology0.95055146
69MP0005387_immune_system_phenotype0.93926192
70MP0001790_abnormal_immune_system0.93926192
71MP0000631_abnormal_neuroendocrine_gland0.92717321
72MP0008932_abnormal_embryonic_tissue0.90446629
73MP0001919_abnormal_reproductive_system0.88463509
74MP0001697_abnormal_embryo_size0.87117310
75MP0006292_abnormal_olfactory_placode0.85244654
76MP0003111_abnormal_nucleus_morphology0.84558907
77MP0005379_endocrine/exocrine_gland_phen0.83173659
78MP0005395_other_phenotype0.82860873
79MP0002148_abnormal_hypersensitivity_rea0.82619664
80MP0002088_abnormal_embryonic_growth/wei0.81416960
81MP0003300_gastrointestinal_ulcer0.80833339
82MP0002210_abnormal_sex_determination0.79515158
83MP0002722_abnormal_immune_system0.78933932
84MP0000647_abnormal_sebaceous_gland0.78604414
85MP0003984_embryonic_growth_retardation0.77038033
86MP0005380_embryogenesis_phenotype0.75845048
87MP0001672_abnormal_embryogenesis/_devel0.75845048
88MP0005083_abnormal_biliary_tract0.74971235
89MP0005248_abnormal_Harderian_gland0.74655684
90MP0001968_abnormal_touch/_nociception0.74155302
91MP0004215_abnormal_myocardial_fiber0.74103584
92MP0005499_abnormal_olfactory_system0.73588731
93MP0005394_taste/olfaction_phenotype0.73588731
94MP0001929_abnormal_gametogenesis0.72737964
95MP0001666_abnormal_nutrient_absorption0.72439566
96MP0002736_abnormal_nociception_after0.72347119
97MP0000372_irregular_coat_pigmentation0.71653472
98MP0005187_abnormal_penis_morphology0.71523346
99MP0001293_anophthalmia0.70619644
100MP0000716_abnormal_immune_system0.70240676

Predicted human phenotypes

RankGene SetZ-score
1Dyschromatopsia (HP:0007641)4.47887984
2Stomatitis (HP:0010280)3.87621016
3Pancreatic cysts (HP:0001737)2.95132160
4Limb hypertonia (HP:0002509)2.88528580
5Abnormality of macular pigmentation (HP:0008002)2.81896950
6Increased hepatocellular lipid droplets (HP:0006565)2.80213361
7Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.75689822
8Abnormality of alanine metabolism (HP:0010916)2.75689822
9Hyperalaninemia (HP:0003348)2.75689822
10IgM deficiency (HP:0002850)2.66269476
11Clubbing of toes (HP:0100760)2.63816121
12Abnormality of the renal cortex (HP:0011035)2.63635942
13Molar tooth sign on MRI (HP:0002419)2.61292364
14Abnormality of midbrain morphology (HP:0002418)2.61292364
15Renal cortical cysts (HP:0000803)2.59478380
16Nephronophthisis (HP:0000090)2.56871032
17Bile duct proliferation (HP:0001408)2.55964054
18Abnormal biliary tract physiology (HP:0012439)2.55964054
19Increased CSF lactate (HP:0002490)2.55012108
20Abnormality of T cell physiology (HP:0011840)2.48129969
21Volvulus (HP:0002580)2.47146128
22Central scotoma (HP:0000603)2.41123742
23Abnormality of the renal medulla (HP:0100957)2.38717936
24Lipid accumulation in hepatocytes (HP:0006561)2.34355669
25Hyperglycinuria (HP:0003108)2.29240118
26Meckel diverticulum (HP:0002245)2.27475570
27IgG deficiency (HP:0004315)2.26590561
28Abnormality of the ileum (HP:0001549)2.25451494
29Acute necrotizing encephalopathy (HP:0006965)2.25232880
30IgA deficiency (HP:0002720)2.23704037
31Abnormality of the columella (HP:0009929)2.23549429
32Genetic anticipation (HP:0003743)2.20817158
33Pancreatic fibrosis (HP:0100732)2.20690203
34Acute encephalopathy (HP:0006846)2.17229456
35Reduced antithrombin III activity (HP:0001976)2.16677706
36Renal Fanconi syndrome (HP:0001994)2.16556452
37Poor head control (HP:0002421)2.15756648
38Colon cancer (HP:0003003)2.14674739
39Hyperglycinemia (HP:0002154)2.12432955
40Mitochondrial inheritance (HP:0001427)2.12113217
41Myelodysplasia (HP:0002863)2.11018834
42Abnormality of chromosome stability (HP:0003220)2.10999773
43Hypochromic microcytic anemia (HP:0004840)2.10319138
44Abolished electroretinogram (ERG) (HP:0000550)2.09646800
45B lymphocytopenia (HP:0010976)2.09066015
46Abnormality of B cell number (HP:0010975)2.09037452
473-Methylglutaconic aciduria (HP:0003535)2.08198528
48Supernumerary spleens (HP:0009799)2.07455446
49Aplasia/Hypoplasia of the uvula (HP:0010293)2.06511311
50Increased serum lactate (HP:0002151)2.06361880
51Progressive macrocephaly (HP:0004481)2.06115936
52Autoimmune hemolytic anemia (HP:0001890)2.04320833
53Neoplasm of the adrenal cortex (HP:0100641)2.03478622
54Acute myeloid leukemia (HP:0004808)2.03265848
55Abnormality of the preputium (HP:0100587)2.01537735
56Capillary hemangiomas (HP:0005306)2.01289754
57Ectopic kidney (HP:0000086)2.01199775
58True hermaphroditism (HP:0010459)2.00567620
59Absent rod-and cone-mediated responses on ERG (HP:0007688)1.98509852
60Aplasia/hypoplasia of the uterus (HP:0008684)1.97852528
61Rhabdomyosarcoma (HP:0002859)1.97811768
62Abnormality of the labia minora (HP:0012880)1.96883308
63Medial flaring of the eyebrow (HP:0010747)1.95887147
64Abnormal rod and cone electroretinograms (HP:0008323)1.93896332
65Aplasia/Hypoplasia of the tibia (HP:0005772)1.91710943
66Stomach cancer (HP:0012126)1.88531229
67Thyroiditis (HP:0100646)1.88311055
68Birth length less than 3rd percentile (HP:0003561)1.88208801
69Decreased central vision (HP:0007663)1.87339006
70Aplasia/Hypoplasia of the tongue (HP:0010295)1.87104205
71Abnormality of T cells (HP:0002843)1.84319858
72Vitreoretinal degeneration (HP:0000655)1.83118019
73Abnormality of the fingertips (HP:0001211)1.82892730
74Exertional dyspnea (HP:0002875)1.82219500
75Intestinal atresia (HP:0011100)1.82105799
76Abnormal number of erythroid precursors (HP:0012131)1.80334720
77Abnormality of serine family amino acid metabolism (HP:0010894)1.78214847
78Abnormality of glycine metabolism (HP:0010895)1.78214847
79Macular degeneration (HP:0000608)1.77789869
80Abnormality of the phalanges of the 2nd finger (HP:0009541)1.73152929
81Abnormality of serum amino acid levels (HP:0003112)1.72544021
82Triphalangeal thumb (HP:0001199)1.72395751
83Facial hemangioma (HP:0000329)1.72386341
84Thyroid-stimulating hormone excess (HP:0002925)1.71850454
85Hepatocellular necrosis (HP:0001404)1.71532507
86Neutropenia (HP:0001875)1.71243274
87Methylmalonic acidemia (HP:0002912)1.70741222
88Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.69358232
89Oligodactyly (hands) (HP:0001180)1.67095026
90Cone-rod dystrophy (HP:0000548)1.66535284
91Abnormality of cells of the erythroid lineage (HP:0012130)1.66303337
92Congenital stationary night blindness (HP:0007642)1.65851963
93Attenuation of retinal blood vessels (HP:0007843)1.65370693
94Abnormal mitochondria in muscle tissue (HP:0008316)1.65356398
95Short tibia (HP:0005736)1.64477948
96Abnormality of urine glucose concentration (HP:0011016)1.62950546
97Glycosuria (HP:0003076)1.62950546
98Sloping forehead (HP:0000340)1.62461709
99Type II lissencephaly (HP:0007260)1.60505429
100Abnormality of the pons (HP:0007361)1.60396252

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK24.68951287
2MKNK13.17782740
3PLK43.12619223
4EIF2AK32.91416530
5AKT32.71508067
6SRPK12.52214155
7NUAK12.39598668
8TSSK62.17318535
9MST42.13074039
10FRK2.09976915
11WNK32.00405746
12BRD41.96969543
13ZAK1.90606027
14TRIM281.71182154
15PASK1.69964054
16EIF2AK11.69652600
17ERBB31.64194046
18NLK1.62903829
19STK391.62244701
20TAOK31.61923765
21OXSR11.56915828
22TAF11.49175934
23TNIK1.46682776
24CSNK1A1L1.44802223
25TEC1.44537922
26CSNK1G11.41557987
27TXK1.39169136
28ADRBK21.34562326
29MAP3K41.33059317
30PAK31.32313900
31RPS6KA41.30924034
32SGK21.29760024
33EIF2AK21.27727114
34STK41.26150895
35GRK11.23741621
36ACVR1B1.23651663
37INSRR1.21895162
38PDK21.21391595
39VRK11.20158456
40TLK11.19848489
41BMPR21.18940422
42BUB11.16528855
43CSNK1G31.16031643
44DYRK31.14073944
45STK161.08331304
46PLK31.07976854
47NEK11.07389582
48WEE11.00296193
49ATR0.97801335
50VRK20.95137876
51PBK0.93501387
52SIK30.91813646
53BCR0.88157443
54TGFBR10.87644925
55WNK40.85359369
56ITK0.85349130
57IRAK40.79579480
58CHUK0.78272812
59PLK20.77840431
60BMPR1B0.76306949
61IKBKB0.75586824
62RPS6KA50.71416865
63MAP4K20.71270664
64TIE10.70487027
65MAP3K140.64878872
66CSNK1G20.64523827
67SGK30.61674315
68CDK60.59519173
69ATM0.58168097
70RPS6KB20.57597513
71MAPK130.56155732
72IKBKE0.55354290
73CASK0.55038979
74OBSCN0.54768757
75SGK4940.53967835
76SGK2230.53967835
77ALK0.53811023
78BRSK20.53068331
79BTK0.53030141
80CAMK40.52756007
81IRAK10.50613060
82NEK60.46608480
83WNK10.45954782
84PIM10.45581350
85MELK0.44454990
86PLK10.42627067
87STK38L0.42035665
88TNK20.41794225
89CLK10.41512431
90CSNK1D0.39420976
91PIK3CG0.38734838
92DAPK20.37905480
93CAMKK20.35541677
94CHEK20.35370260
95STK240.34492637
96MAPKAPK30.30777655
97CHEK10.30076108
98CDK190.29640398
99RPS6KB10.28661092
100CDK40.26359704

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.89862493
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.73648013
3RNA polymerase_Homo sapiens_hsa030203.34940295
4Proteasome_Homo sapiens_hsa030503.21486890
5RNA degradation_Homo sapiens_hsa030182.81860698
6RNA transport_Homo sapiens_hsa030132.76936406
7Asthma_Homo sapiens_hsa053102.57285910
8Basal transcription factors_Homo sapiens_hsa030222.50538225
9Ribosome_Homo sapiens_hsa030102.40305417
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.14258028
11One carbon pool by folate_Homo sapiens_hsa006701.98132778
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.95722320
13Allograft rejection_Homo sapiens_hsa053301.94265106
14Autoimmune thyroid disease_Homo sapiens_hsa053201.81274679
15Propanoate metabolism_Homo sapiens_hsa006401.79137753
16Mismatch repair_Homo sapiens_hsa034301.78235902
17Spliceosome_Homo sapiens_hsa030401.67052798
18Regulation of autophagy_Homo sapiens_hsa041401.66994682
19Pyrimidine metabolism_Homo sapiens_hsa002401.65615821
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.60648940
21Homologous recombination_Homo sapiens_hsa034401.59473339
22Fanconi anemia pathway_Homo sapiens_hsa034601.55873217
23Non-homologous end-joining_Homo sapiens_hsa034501.49400417
24Purine metabolism_Homo sapiens_hsa002301.37108333
25Nucleotide excision repair_Homo sapiens_hsa034201.34500640
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.31306599
27Primary immunodeficiency_Homo sapiens_hsa053401.30372785
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.28450685
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.28269181
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.26028379
31T cell receptor signaling pathway_Homo sapiens_hsa046601.25338036
32Systemic lupus erythematosus_Homo sapiens_hsa053221.20975752
33DNA replication_Homo sapiens_hsa030301.20550130
34NF-kappa B signaling pathway_Homo sapiens_hsa040641.19036441
35Sulfur metabolism_Homo sapiens_hsa009201.17610130
36Phototransduction_Homo sapiens_hsa047441.16817327
37Nitrogen metabolism_Homo sapiens_hsa009101.15783658
38p53 signaling pathway_Homo sapiens_hsa041151.09110992
39Circadian rhythm_Homo sapiens_hsa047101.05222764
40Selenocompound metabolism_Homo sapiens_hsa004501.04874402
41Base excision repair_Homo sapiens_hsa034101.03853846
42Linoleic acid metabolism_Homo sapiens_hsa005911.01896258
43Transcriptional misregulation in cancer_Homo sapiens_hsa052020.99518798
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.99308083
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.98883541
46mRNA surveillance pathway_Homo sapiens_hsa030150.96594938
47Epstein-Barr virus infection_Homo sapiens_hsa051690.96262586
48Type I diabetes mellitus_Homo sapiens_hsa049400.95451423
49Jak-STAT signaling pathway_Homo sapiens_hsa046300.91803037
50Vitamin B6 metabolism_Homo sapiens_hsa007500.90622842
51Oxidative phosphorylation_Homo sapiens_hsa001900.89718850
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.88565891
53NOD-like receptor signaling pathway_Homo sapiens_hsa046210.86403524
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86039682
55Steroid hormone biosynthesis_Homo sapiens_hsa001400.84686626
56Graft-versus-host disease_Homo sapiens_hsa053320.83242811
57Ether lipid metabolism_Homo sapiens_hsa005650.82098847
58Cell cycle_Homo sapiens_hsa041100.79422871
59Hematopoietic cell lineage_Homo sapiens_hsa046400.78412106
60RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.77885533
61Measles_Homo sapiens_hsa051620.75800480
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.74567269
63Huntingtons disease_Homo sapiens_hsa050160.72624659
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.66152305
65Nicotine addiction_Homo sapiens_hsa050330.66148040
66Peroxisome_Homo sapiens_hsa041460.63023659
67Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.62935046
68Viral carcinogenesis_Homo sapiens_hsa052030.61581360
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.58336387
70Arachidonic acid metabolism_Homo sapiens_hsa005900.56470991
71Parkinsons disease_Homo sapiens_hsa050120.55019370
72Caffeine metabolism_Homo sapiens_hsa002320.53552141
73Alcoholism_Homo sapiens_hsa050340.52755610
74Dorso-ventral axis formation_Homo sapiens_hsa043200.51412062
75TGF-beta signaling pathway_Homo sapiens_hsa043500.49835160
76Legionellosis_Homo sapiens_hsa051340.49649216
77Prostate cancer_Homo sapiens_hsa052150.47998743
78TNF signaling pathway_Homo sapiens_hsa046680.47771097
79Olfactory transduction_Homo sapiens_hsa047400.47439811
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46646496
81Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45596310
82Glycerolipid metabolism_Homo sapiens_hsa005610.45550241
83ABC transporters_Homo sapiens_hsa020100.42254045
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41306736
85Herpes simplex infection_Homo sapiens_hsa051680.41281009
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41149254
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40002137
88Colorectal cancer_Homo sapiens_hsa052100.39068028
89Tryptophan metabolism_Homo sapiens_hsa003800.37599206
90alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.35935815
91Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33466188
92Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.33034260
93Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.30677658
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30045956
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.29086182
96HTLV-I infection_Homo sapiens_hsa051660.28546728
97Metabolic pathways_Homo sapiens_hsa011000.27899816
98Retinol metabolism_Homo sapiens_hsa008300.27404008
99Lysine degradation_Homo sapiens_hsa003100.25459128
100Taste transduction_Homo sapiens_hsa047420.23070681

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