NPIPP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.44486703
2postsynaptic membrane organization (GO:0001941)3.72216588
3pyrimidine nucleobase catabolic process (GO:0006208)3.55125324
4presynaptic membrane organization (GO:0097090)3.47374708
5presynaptic membrane assembly (GO:0097105)3.39189663
6behavioral response to ethanol (GO:0048149)3.36584938
7epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.36361528
8protein polyglutamylation (GO:0018095)3.32801551
9transmission of nerve impulse (GO:0019226)3.19610261
10substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.10087105
11substrate-independent telencephalic tangential migration (GO:0021826)3.10087105
12positive regulation of dendritic spine morphogenesis (GO:0061003)3.07687923
13dendritic spine morphogenesis (GO:0060997)3.05508265
14positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.04165401
15membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.01999733
16water-soluble vitamin biosynthetic process (GO:0042364)3.00174427
17regulation of cilium movement (GO:0003352)3.00026111
18regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.99679736
19nucleobase catabolic process (GO:0046113)2.98921279
20nonmotile primary cilium assembly (GO:0035058)2.94188027
21negative regulation of DNA-dependent DNA replication (GO:2000104)2.93123431
22nephron epithelium morphogenesis (GO:0072088)2.92551963
23nephron tubule morphogenesis (GO:0072078)2.92551963
24piRNA metabolic process (GO:0034587)2.92550613
25positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.92323581
26axonal fasciculation (GO:0007413)2.89008378
27mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.84234290
28neurotransmitter-gated ion channel clustering (GO:0072578)2.81612106
29axon ensheathment in central nervous system (GO:0032291)2.80320492
30central nervous system myelination (GO:0022010)2.80320492
31negative regulation of telomere maintenance (GO:0032205)2.80061677
32neuron recognition (GO:0008038)2.78808446
33regulation of telomere maintenance (GO:0032204)2.78423637
34short-term memory (GO:0007614)2.77245965
35C4-dicarboxylate transport (GO:0015740)2.77025993
36negative regulation of synaptic transmission, GABAergic (GO:0032229)2.74090824
37mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.72945439
38mitochondrial respiratory chain complex I assembly (GO:0032981)2.72945439
39NADH dehydrogenase complex assembly (GO:0010257)2.72945439
40single strand break repair (GO:0000012)2.72159033
41neuron cell-cell adhesion (GO:0007158)2.71692098
42protein complex biogenesis (GO:0070271)2.70286961
43regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.67123744
44epithelial cilium movement (GO:0003351)2.66941928
45DNA methylation involved in gamete generation (GO:0043046)2.64446879
46male meiosis I (GO:0007141)2.61161162
47negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.61103971
48negative regulation of translation, ncRNA-mediated (GO:0040033)2.61103971
49regulation of translation, ncRNA-mediated (GO:0045974)2.61103971
50resolution of meiotic recombination intermediates (GO:0000712)2.60471319
51regulation of penile erection (GO:0060405)2.57300557
52protein localization to synapse (GO:0035418)2.55648425
53neuronal action potential propagation (GO:0019227)2.55646073
54synapsis (GO:0007129)2.55264346
55regulation of microtubule-based movement (GO:0060632)2.52616969
56cell proliferation in forebrain (GO:0021846)2.52434379
57synaptic vesicle maturation (GO:0016188)2.52422325
58replication fork processing (GO:0031297)2.49150287
59vocalization behavior (GO:0071625)2.47982618
60neuronal ion channel clustering (GO:0045161)2.47933784
61mitochondrial respiratory chain complex assembly (GO:0033108)2.45487541
62acrosome reaction (GO:0007340)2.44028481
63detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.42967651
64somite development (GO:0061053)2.41993310
65establishment of mitochondrion localization (GO:0051654)2.41486187
66response to pheromone (GO:0019236)2.40645744
67renal tubule morphogenesis (GO:0061333)2.40413427
68regulation of DNA endoreduplication (GO:0032875)2.39620121
69hindbrain development (GO:0030902)2.39331394
70protein localization to Golgi apparatus (GO:0034067)2.38538046
71establishment of protein localization to Golgi (GO:0072600)2.38509483
72protein-cofactor linkage (GO:0018065)2.38324235
73synaptic transmission, glutamatergic (GO:0035249)2.37897942
74regulation of neurotransmitter uptake (GO:0051580)2.36732164
75intraciliary transport (GO:0042073)2.36268277
76regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.35681592
77protein localization to cilium (GO:0061512)2.34404986
78negative regulation of appetite (GO:0032099)2.34266389
79negative regulation of response to food (GO:0032096)2.34266389
80chemosensory behavior (GO:0007635)2.34053554
81establishment of protein localization to mitochondrial membrane (GO:0090151)2.33802567
82regulation of short-term neuronal synaptic plasticity (GO:0048172)2.33131436
83synaptic transmission, cholinergic (GO:0007271)2.32732645
84regulation of nuclear cell cycle DNA replication (GO:0033262)2.32463981
85auditory behavior (GO:0031223)2.32363354
86protein targeting to Golgi (GO:0000042)2.32273712
87fucose catabolic process (GO:0019317)2.31602207
88L-fucose metabolic process (GO:0042354)2.31602207
89L-fucose catabolic process (GO:0042355)2.31602207
90neurofilament cytoskeleton organization (GO:0060052)2.31575215
91synapse assembly (GO:0007416)2.30711644
92brain morphogenesis (GO:0048854)2.30542994
93spinal cord development (GO:0021510)2.29718331
94kidney morphogenesis (GO:0060993)2.28602972
95regulation of meiosis I (GO:0060631)2.28213403
96ionotropic glutamate receptor signaling pathway (GO:0035235)2.27109272
97regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.26155811
98regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.26155811
99cerebral cortex radially oriented cell migration (GO:0021799)2.25795271
100behavioral defense response (GO:0002209)2.24132736

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.41215033
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.76002976
3ZNF274_21170338_ChIP-Seq_K562_Hela3.03280092
4VDR_22108803_ChIP-Seq_LS180_Human2.84268452
5GBX2_23144817_ChIP-Seq_PC3_Human2.61737053
6RBPJ_22232070_ChIP-Seq_NCS_Mouse2.54171825
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.49033907
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.40082011
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.32508970
10REST_21632747_ChIP-Seq_MESCs_Mouse2.24516393
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.23685375
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.96370722
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.90947639
14CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.89963490
15CTBP1_25329375_ChIP-Seq_LNCAP_Human1.88012828
16CBX2_27304074_Chip-Seq_ESCs_Mouse1.87565448
17CTBP2_25329375_ChIP-Seq_LNCAP_Human1.81067991
18ZFP57_27257070_Chip-Seq_ESCs_Mouse1.79353394
19IGF1R_20145208_ChIP-Seq_DFB_Human1.78265377
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.77883005
21EZH2_27304074_Chip-Seq_ESCs_Mouse1.77019726
22FUS_26573619_Chip-Seq_HEK293_Human1.76660200
23KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.73576005
24REST_18959480_ChIP-ChIP_MESCs_Mouse1.73548627
25GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.68987098
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61172046
27RNF2_27304074_Chip-Seq_NSC_Mouse1.60747185
28P300_19829295_ChIP-Seq_ESCs_Human1.60549695
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59845631
30BMI1_23680149_ChIP-Seq_NPCS_Mouse1.59444689
31JARID2_20064375_ChIP-Seq_MESCs_Mouse1.58461637
32EWS_26573619_Chip-Seq_HEK293_Human1.54709571
33GABP_17652178_ChIP-ChIP_JURKAT_Human1.49501646
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.41181830
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.37574872
36EZH2_27294783_Chip-Seq_ESCs_Mouse1.37342118
37EST1_17652178_ChIP-ChIP_JURKAT_Human1.36858656
38CBP_20019798_ChIP-Seq_JUKART_Human1.34538111
39IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34538111
40TAF15_26573619_Chip-Seq_HEK293_Human1.32972963
41MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30909527
42SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.30086420
43RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.30058635
44MYC_18940864_ChIP-ChIP_HL60_Human1.29112423
45POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28808308
46TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28808308
47SMAD4_21799915_ChIP-Seq_A2780_Human1.25306396
48SUZ12_27294783_Chip-Seq_ESCs_Mouse1.25253236
49BCAT_22108803_ChIP-Seq_LS180_Human1.25030942
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25006587
51ETV2_25802403_ChIP-Seq_MESCs_Mouse1.24596945
52UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23816905
53KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21437934
54CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20209679
55RNF2_27304074_Chip-Seq_ESCs_Mouse1.19875211
56IRF1_19129219_ChIP-ChIP_H3396_Human1.19153256
57EED_16625203_ChIP-ChIP_MESCs_Mouse1.18837933
58EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.18169139
59FLI1_27457419_Chip-Seq_LIVER_Mouse1.17862519
60TP53_22573176_ChIP-Seq_HFKS_Human1.17212747
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16631588
62SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.16534218
63RUNX2_22187159_ChIP-Seq_PCA_Human1.16519203
64SMAD3_21741376_ChIP-Seq_ESCs_Human1.14410606
65MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13719668
66STAT3_23295773_ChIP-Seq_U87_Human1.13575247
67PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12624137
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.12517396
69JARID2_20075857_ChIP-Seq_MESCs_Mouse1.12472137
70SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.12298867
71RNF2_18974828_ChIP-Seq_MESCs_Mouse1.12063677
72EZH2_18974828_ChIP-Seq_MESCs_Mouse1.12063677
73TCF4_23295773_ChIP-Seq_U87_Human1.10465905
74CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.10410965
75ER_23166858_ChIP-Seq_MCF-7_Human1.08338860
76RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.07715525
77AR_25329375_ChIP-Seq_VCAP_Human1.06758166
78SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.05840778
79ETS1_20019798_ChIP-Seq_JURKAT_Human1.04038874
80PCGF2_27294783_Chip-Seq_ESCs_Mouse1.03041944
81NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02728706
82TP63_19390658_ChIP-ChIP_HaCaT_Human1.02486559
83NCOR_22424771_ChIP-Seq_293T_Human1.00458652
84GATA1_26923725_Chip-Seq_HPCs_Mouse1.00356074
85SMAD4_21741376_ChIP-Seq_EPCs_Human0.98242290
86FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.98100429
87CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.96232820
88TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96141874
89E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.95504457
90SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.95181442
91PIAS1_25552417_ChIP-Seq_VCAP_Human0.94953713
92TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94443318
93TCF4_22108803_ChIP-Seq_LS180_Human0.92444019
94SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.91409462
95CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.90453625
96RING1B_27294783_Chip-Seq_ESCs_Mouse0.89056113
97PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.88806521
98PCGF2_27294783_Chip-Seq_NPCs_Mouse0.88245599
99JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.87449978
100ERA_21632823_ChIP-Seq_H3396_Human0.87185869

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting3.64869016
2MP0003122_maternal_imprinting3.03601495
3MP0006292_abnormal_olfactory_placode2.98317400
4MP0003121_genomic_imprinting2.80240541
5MP0008877_abnormal_DNA_methylation2.73293181
6MP0003123_paternal_imprinting2.60365270
7MP0004885_abnormal_endolymph2.59783888
8MP0003880_abnormal_central_pattern2.46717958
9MP0004859_abnormal_synaptic_plasticity2.31857741
10MP0001968_abnormal_touch/_nociception2.11055855
11MP0009046_muscle_twitch2.07456832
12MP0006276_abnormal_autonomic_nervous2.06201489
13MP0001529_abnormal_vocalization2.02778783
14MP0002272_abnormal_nervous_system1.96830479
15MP0001984_abnormal_olfaction1.96338302
16MP0009745_abnormal_behavioral_response1.93730181
17MP0003635_abnormal_synaptic_transmissio1.84294129
18MP0002102_abnormal_ear_morphology1.75397192
19MP0005551_abnormal_eye_electrophysiolog1.74060029
20MP0000778_abnormal_nervous_system1.70856318
21MP0002736_abnormal_nociception_after1.68032719
22MP0002063_abnormal_learning/memory/cond1.67255287
23MP0001188_hyperpigmentation1.66238828
24MP0002064_seizures1.61114724
25MP0002572_abnormal_emotion/affect_behav1.60830304
26MP0003890_abnormal_embryonic-extraembry1.58053061
27MP0001486_abnormal_startle_reflex1.58020888
28MP0005423_abnormal_somatic_nervous1.55031443
29MP0002735_abnormal_chemical_nociception1.53476891
30MP0002557_abnormal_social/conspecific_i1.53036368
31MP0004133_heterotaxia1.52280423
32MP0004142_abnormal_muscle_tone1.51634236
33MP0002837_dystrophic_cardiac_calcinosis1.51438425
34MP0004270_analgesia1.51026374
35MP0000631_abnormal_neuroendocrine_gland1.46825672
36MP0002734_abnormal_mechanical_nocicepti1.46596494
37MP0001485_abnormal_pinna_reflex1.46027975
38MP0002184_abnormal_innervation1.43307390
39MP0009379_abnormal_foot_pigmentation1.42447911
40MP0002638_abnormal_pupillary_reflex1.40487494
41MP0001970_abnormal_pain_threshold1.39646491
42MP0006072_abnormal_retinal_apoptosis1.39517874
43MP0000955_abnormal_spinal_cord1.36895029
44MP0002733_abnormal_thermal_nociception1.36384215
45MP0008789_abnormal_olfactory_epithelium1.31303932
46MP0005394_taste/olfaction_phenotype1.30181865
47MP0005499_abnormal_olfactory_system1.30181865
48MP0001293_anophthalmia1.28200846
49MP0002067_abnormal_sensory_capabilities1.27558119
50MP0002938_white_spotting1.26415498
51MP0002160_abnormal_reproductive_system1.24606135
52MP0003646_muscle_fatigue1.23648916
53MP0003195_calcinosis1.21867873
54MP0002822_catalepsy1.21118785
55MP0005646_abnormal_pituitary_gland1.18560274
56MP0009780_abnormal_chondrocyte_physiolo1.16876229
57MP0005377_hearing/vestibular/ear_phenot1.16750946
58MP0003878_abnormal_ear_physiology1.16750946
59MP0004811_abnormal_neuron_physiology1.15824338
60MP0005386_behavior/neurological_phenoty1.15553179
61MP0004924_abnormal_behavior1.15553179
62MP0008775_abnormal_heart_ventricle1.13930205
63MP0002882_abnormal_neuron_morphology1.12380627
64MP0002752_abnormal_somatic_nervous1.10432869
65MP0003879_abnormal_hair_cell1.09348654
66MP0001440_abnormal_grooming_behavior1.09178330
67MP0000049_abnormal_middle_ear1.08752232
68MP0002876_abnormal_thyroid_physiology1.08203816
69MP0001502_abnormal_circadian_rhythm1.05226787
70MP0005645_abnormal_hypothalamus_physiol1.04501938
71MP0002152_abnormal_brain_morphology1.02936979
72MP0002653_abnormal_ependyma_morphology1.01887773
73MP0005084_abnormal_gallbladder_morpholo1.01646450
74MP0004742_abnormal_vestibular_system1.00544921
75MP0003942_abnormal_urinary_system0.99592766
76MP0008995_early_reproductive_senescence0.99279199
77MP0005253_abnormal_eye_physiology0.99214636
78MP0004147_increased_porphyrin_level0.97566754
79MP0001963_abnormal_hearing_physiology0.97424039
80MP0001905_abnormal_dopamine_level0.96615592
81MP0003698_abnormal_male_reproductive0.96163200
82MP0008872_abnormal_physiological_respon0.95845676
83MP0005195_abnormal_posterior_eye0.95608292
84MP0003938_abnormal_ear_development0.94490684
85MP0003136_yellow_coat_color0.94127180
86MP0002229_neurodegeneration0.92909437
87MP0008058_abnormal_DNA_repair0.91308765
88MP0002210_abnormal_sex_determination0.91255372
89MP0003861_abnormal_nervous_system0.90909017
90MP0005410_abnormal_fertilization0.89914471
91MP0001986_abnormal_taste_sensitivity0.89639754
92MP0003283_abnormal_digestive_organ0.89624533
93MP0003937_abnormal_limbs/digits/tail_de0.88684233
94MP0003755_abnormal_palate_morphology0.88519082
95MP0001501_abnormal_sleep_pattern0.88044083
96MP0005389_reproductive_system_phenotype0.86561729
97MP0002233_abnormal_nose_morphology0.86296142
98MP0002066_abnormal_motor_capabilities/c0.85305228
99MP0001299_abnormal_eye_distance/0.83812952
100MP0001929_abnormal_gametogenesis0.81448418

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)3.63013808
2Abnormality of midbrain morphology (HP:0002418)3.56882236
3Molar tooth sign on MRI (HP:0002419)3.56882236
4Nephronophthisis (HP:0000090)3.51613944
5Pancreatic fibrosis (HP:0100732)3.01603891
6Medial flaring of the eyebrow (HP:0010747)3.01310670
7Acute necrotizing encephalopathy (HP:0006965)2.85224678
8Limb dystonia (HP:0002451)2.74935677
9Polyphagia (HP:0002591)2.73346252
10Abnormality of the renal medulla (HP:0100957)2.66761596
11Hyperthyroidism (HP:0000836)2.66262747
12Pancreatic cysts (HP:0001737)2.64683679
13Type II lissencephaly (HP:0007260)2.64525854
14Progressive macrocephaly (HP:0004481)2.59763841
15Volvulus (HP:0002580)2.56759402
16Gait imbalance (HP:0002141)2.55243127
17Epileptic encephalopathy (HP:0200134)2.51973653
18Abnormal rod and cone electroretinograms (HP:0008323)2.50566546
19Lissencephaly (HP:0001339)2.49173022
20Colon cancer (HP:0003003)2.47035711
21Myokymia (HP:0002411)2.45283925
22Acute encephalopathy (HP:0006846)2.45050971
23Abnormal mitochondria in muscle tissue (HP:0008316)2.37733950
24Progressive cerebellar ataxia (HP:0002073)2.36908543
25Pachygyria (HP:0001302)2.35768679
26True hermaphroditism (HP:0010459)2.35740487
27Broad-based gait (HP:0002136)2.31878898
28Focal seizures (HP:0007359)2.31465568
29Hepatocellular necrosis (HP:0001404)2.31357741
30Hyperventilation (HP:0002883)2.29537061
31Absent rod-and cone-mediated responses on ERG (HP:0007688)2.29386991
32Drooling (HP:0002307)2.28514347
33Septo-optic dysplasia (HP:0100842)2.27738636
34Mitochondrial inheritance (HP:0001427)2.21660124
35Congenital primary aphakia (HP:0007707)2.21373445
36Increased CSF lactate (HP:0002490)2.18873343
37Abnormal hair whorl (HP:0010721)2.18868397
38Spastic tetraplegia (HP:0002510)2.15218265
39Nephrogenic diabetes insipidus (HP:0009806)2.14286014
40Dynein arm defect of respiratory motile cilia (HP:0012255)2.13349293
41Absent/shortened dynein arms (HP:0200106)2.13349293
42Hepatic necrosis (HP:0002605)2.13251988
43Congenital stationary night blindness (HP:0007642)2.12879638
44Supernumerary spleens (HP:0009799)2.08112295
45Focal motor seizures (HP:0011153)2.07856642
46Chronic hepatic failure (HP:0100626)2.07187739
47Tubular atrophy (HP:0000092)2.04075223
48Abolished electroretinogram (ERG) (HP:0000550)1.99689754
49Excessive salivation (HP:0003781)1.98476381
50Hepatoblastoma (HP:0002884)1.98333642
51Genital tract atresia (HP:0001827)1.97681212
52Amblyopia (HP:0000646)1.97618675
53Growth hormone deficiency (HP:0000824)1.97075643
54Optic nerve hypoplasia (HP:0000609)1.96106742
55Neoplasm of the adrenal cortex (HP:0100641)1.95783751
56Polydipsia (HP:0001959)1.94971753
57Abnormal drinking behavior (HP:0030082)1.94971753
58Abnormal respiratory motile cilium morphology (HP:0005938)1.94482373
59Abnormal respiratory epithelium morphology (HP:0012253)1.94482373
60Pendular nystagmus (HP:0012043)1.93218823
61Sclerocornea (HP:0000647)1.92855735
62Retinal dysplasia (HP:0007973)1.92663953
63Intestinal atresia (HP:0011100)1.92501777
64Prominent nasal bridge (HP:0000426)1.92182742
65Vaginal atresia (HP:0000148)1.91544702
66Narrow forehead (HP:0000341)1.89047686
67Anencephaly (HP:0002323)1.87729093
68Febrile seizures (HP:0002373)1.86952529
69Small hand (HP:0200055)1.86869333
70Hypothermia (HP:0002045)1.86206885
71Oligodactyly (hands) (HP:0001180)1.85350166
72Optic disc pallor (HP:0000543)1.84694175
73Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.84662660
74Abnormal eating behavior (HP:0100738)1.83359341
75Abnormality of the aortic arch (HP:0012303)1.79841679
76Cystic liver disease (HP:0006706)1.79824539
77Specific learning disability (HP:0001328)1.79641457
78Postaxial hand polydactyly (HP:0001162)1.78350798
79Poor suck (HP:0002033)1.77580181
80Anophthalmia (HP:0000528)1.77124778
81Decreased muscle mass (HP:0003199)1.75832891
82Aganglionic megacolon (HP:0002251)1.74964690
83Atonic seizures (HP:0010819)1.74565803
84Rib fusion (HP:0000902)1.73941099
85Poor coordination (HP:0002370)1.73850332
86Generalized tonic-clonic seizures (HP:0002069)1.72221994
87Asplenia (HP:0001746)1.72219028
88Protruding tongue (HP:0010808)1.71794352
89Failure to thrive in infancy (HP:0001531)1.69247950
90Cerebral edema (HP:0002181)1.69078165
91Sleep apnea (HP:0010535)1.68994805
92Thyroid-stimulating hormone excess (HP:0002925)1.68560722
93Multicystic kidney dysplasia (HP:0000003)1.67237820
94Poor eye contact (HP:0000817)1.66367971
95Aplasia/Hypoplasia of the spleen (HP:0010451)1.66228174
96Hypogonadotrophic hypogonadism (HP:0000044)1.65712480
97Abnormality of the corticospinal tract (HP:0002492)1.64568489
98Dialeptic seizures (HP:0011146)1.64201202
99Hyperglycinemia (HP:0002154)1.63572387
100Abnormal biliary tract physiology (HP:0012439)1.63562380

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.53092860
2MARK13.20345437
3FRK3.08665427
4TNIK2.68839162
5PINK12.68586572
6WNK42.30330536
7MAP4K22.26834548
8TAOK32.13059170
9MAP3K92.06208913
10NTRK32.04115205
11BMPR1B1.86249203
12DYRK21.83121378
13PNCK1.82944346
14MAPK131.82917371
15FGFR21.81219136
16GRK11.69706740
17MAP2K71.67714720
18SIK21.64565107
19WNK31.62002147
20CDC71.60516349
21ADRBK21.55579032
22STK161.55338920
23MINK11.55099871
24EPHA41.54007781
25MAP3K41.53592113
26PLK21.49026254
27MKNK21.45087687
28NTRK21.44952015
29PRKCG1.41307942
30NUAK11.38955226
31PLK41.29224300
32CDK191.23124273
33PIK3CA1.19601849
34ZAK1.18835393
35PHKG11.13856009
36PHKG21.13856009
37CAMK1G1.12136900
38PLK31.11889237
39PAK31.08778653
40TYRO31.06141835
41CSNK1G21.02016251
42NME10.99961816
43OXSR10.94968469
44CAMK10.93967443
45PLK10.93004857
46TIE10.91335498
47CDK30.91279944
48MAP2K60.90459101
49EIF2AK10.89836511
50TTK0.87555539
51CSNK1G10.86299192
52CSNK1E0.82127583
53SGK10.76972813
54PAK60.76629120
55SGK2230.75409345
56SGK4940.75409345
57TLK10.75321460
58BCR0.75261060
59STK390.75123000
60CSNK1G30.74289188
61STK110.68679156
62UHMK10.68330646
63INSRR0.66074800
64NEK20.65480285
65MKNK10.63643099
66CDK50.63395668
67BCKDK0.60467037
68DYRK1B0.59423701
69PRKCH0.59021527
70SGK20.58832222
71DYRK1A0.58814700
72BRAF0.58683473
73ATM0.57276019
74DAPK20.54070970
75PKN10.53951731
76PRKCE0.53934167
77TAF10.53220146
78CDK140.52994697
79CAMK1D0.52732715
80STK30.52622687
81EIF2AK30.50984974
82STK38L0.50186811
83WNK10.49406412
84CHEK20.49326778
85CAMK2A0.48179865
86CSNK1A10.48063970
87CSNK1A1L0.46834762
88PRKACA0.46369153
89PRKCZ0.45860956
90PRKAA10.44111774
91PRKD30.42745810
92CLK10.42701914
93CDK11A0.41708830
94MAP2K40.41455563
95PRKG10.41291037
96PRKDC0.39535846
97NEK10.39152425
98GSK3B0.38576920
99CSNK1D0.38475397
100ADRBK10.37986200

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.00067515
2Oxidative phosphorylation_Homo sapiens_hsa001902.67338822
3Phototransduction_Homo sapiens_hsa047442.26558690
4Protein export_Homo sapiens_hsa030602.25540886
5Parkinsons disease_Homo sapiens_hsa050122.24738854
6Butanoate metabolism_Homo sapiens_hsa006502.18603802
7Fanconi anemia pathway_Homo sapiens_hsa034602.09574106
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.07396090
9Cardiac muscle contraction_Homo sapiens_hsa042601.95437851
10Homologous recombination_Homo sapiens_hsa034401.92843185
11Basal transcription factors_Homo sapiens_hsa030221.88133295
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.85889502
13RNA polymerase_Homo sapiens_hsa030201.61832211
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.58781254
15GABAergic synapse_Homo sapiens_hsa047271.57065077
16Olfactory transduction_Homo sapiens_hsa047401.55453949
17RNA degradation_Homo sapiens_hsa030181.55297142
18Insulin secretion_Homo sapiens_hsa049111.53435944
19Glutamatergic synapse_Homo sapiens_hsa047241.51865786
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50408718
21Morphine addiction_Homo sapiens_hsa050321.49263450
22Circadian entrainment_Homo sapiens_hsa047131.47277272
23Steroid biosynthesis_Homo sapiens_hsa001001.46816926
24Dopaminergic synapse_Homo sapiens_hsa047281.45443600
25Propanoate metabolism_Homo sapiens_hsa006401.45219899
26Vitamin B6 metabolism_Homo sapiens_hsa007501.45204905
27Alzheimers disease_Homo sapiens_hsa050101.44609396
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.42837700
29Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.40506221
30Huntingtons disease_Homo sapiens_hsa050161.40154096
31Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.31832629
32Ribosome_Homo sapiens_hsa030101.29793420
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.24792638
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.24641285
35Synaptic vesicle cycle_Homo sapiens_hsa047211.21986079
36Taste transduction_Homo sapiens_hsa047421.21181772
37Selenocompound metabolism_Homo sapiens_hsa004501.20223946
38Cocaine addiction_Homo sapiens_hsa050301.17044552
39Amphetamine addiction_Homo sapiens_hsa050311.16466893
40Linoleic acid metabolism_Homo sapiens_hsa005911.15971641
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.15444459
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.15244649
43Regulation of autophagy_Homo sapiens_hsa041401.14748499
44Peroxisome_Homo sapiens_hsa041461.12341686
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.09065071
46Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.08621373
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.07158985
48Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.05736417
49Tryptophan metabolism_Homo sapiens_hsa003801.04996221
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.04425445
51RNA transport_Homo sapiens_hsa030130.99837754
52Ether lipid metabolism_Homo sapiens_hsa005650.96892180
53One carbon pool by folate_Homo sapiens_hsa006700.95740717
54Collecting duct acid secretion_Homo sapiens_hsa049660.94608845
55Serotonergic synapse_Homo sapiens_hsa047260.93672558
56Fatty acid metabolism_Homo sapiens_hsa012120.90284051
57Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.88131467
58Long-term depression_Homo sapiens_hsa047300.86089368
59Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.85964007
60Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.82198151
61Fat digestion and absorption_Homo sapiens_hsa049750.76820981
62Oocyte meiosis_Homo sapiens_hsa041140.76138069
63Fatty acid degradation_Homo sapiens_hsa000710.75747770
64Cholinergic synapse_Homo sapiens_hsa047250.75456633
65mRNA surveillance pathway_Homo sapiens_hsa030150.74945074
66Oxytocin signaling pathway_Homo sapiens_hsa049210.71202825
67Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.70796321
68Retinol metabolism_Homo sapiens_hsa008300.69610606
69Metabolic pathways_Homo sapiens_hsa011000.68221600
70Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.67443963
71Mismatch repair_Homo sapiens_hsa034300.67279117
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65415905
73Dorso-ventral axis formation_Homo sapiens_hsa043200.64161480
74Nitrogen metabolism_Homo sapiens_hsa009100.64018937
75Purine metabolism_Homo sapiens_hsa002300.63229403
76Axon guidance_Homo sapiens_hsa043600.61657467
77Hedgehog signaling pathway_Homo sapiens_hsa043400.60060152
78Calcium signaling pathway_Homo sapiens_hsa040200.57455176
79Chemical carcinogenesis_Homo sapiens_hsa052040.56967840
80beta-Alanine metabolism_Homo sapiens_hsa004100.56766755
81Fatty acid elongation_Homo sapiens_hsa000620.56683236
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56674049
83Long-term potentiation_Homo sapiens_hsa047200.52868272
84Spliceosome_Homo sapiens_hsa030400.52566583
85Sulfur relay system_Homo sapiens_hsa041220.52499865
86Wnt signaling pathway_Homo sapiens_hsa043100.52434336
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52233991
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51559292
89Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.50325919
90Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49321980
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49101758
92Primary bile acid biosynthesis_Homo sapiens_hsa001200.48583040
93Basal cell carcinoma_Homo sapiens_hsa052170.46883333
94Nucleotide excision repair_Homo sapiens_hsa034200.45861888
95cAMP signaling pathway_Homo sapiens_hsa040240.44029260
96Cysteine and methionine metabolism_Homo sapiens_hsa002700.43062788
97Salivary secretion_Homo sapiens_hsa049700.42839562
98Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.42574627
99Renin secretion_Homo sapiens_hsa049240.41521643
100Arginine and proline metabolism_Homo sapiens_hsa003300.39117835

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