NPIPA5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)5.17869952
2rRNA methylation (GO:0031167)4.86568090
3sperm motility (GO:0030317)4.76770290
4piRNA metabolic process (GO:0034587)4.51197411
5rRNA modification (GO:0000154)4.38478798
6acrosome reaction (GO:0007340)4.24977001
7axonemal dynein complex assembly (GO:0070286)3.81593175
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.78536419
9axoneme assembly (GO:0035082)3.76842437
10male meiosis I (GO:0007141)3.69676324
11regulation of meiosis I (GO:0060631)3.67482531
12microtubule depolymerization (GO:0007019)3.62809981
13synapsis (GO:0007129)3.58667783
14fusion of sperm to egg plasma membrane (GO:0007342)3.56337224
15protein polyglutamylation (GO:0018095)3.52167251
16spermatid development (GO:0007286)3.51211922
17seminiferous tubule development (GO:0072520)3.48411464
18cilium or flagellum-dependent cell motility (GO:0001539)3.39847818
19fucose catabolic process (GO:0019317)3.38407223
20L-fucose metabolic process (GO:0042354)3.38407223
21L-fucose catabolic process (GO:0042355)3.38407223
22resolution of meiotic recombination intermediates (GO:0000712)3.37585251
23phosphatidylethanolamine biosynthetic process (GO:0006646)3.36926012
24establishment of protein localization to Golgi (GO:0072600)3.36885850
25epithelial cilium movement (GO:0003351)3.36212928
26regulation of glucokinase activity (GO:0033131)3.34221514
27regulation of hexokinase activity (GO:1903299)3.34221514
28protein targeting to Golgi (GO:0000042)3.33609293
29presynaptic membrane assembly (GO:0097105)3.31007679
30regulation of cilium movement (GO:0003352)3.29363331
31cellular ketone body metabolic process (GO:0046950)3.27136327
32DNA methylation involved in gamete generation (GO:0043046)3.26218950
33male meiosis (GO:0007140)3.20284755
34phosphatidylethanolamine metabolic process (GO:0046337)3.18476992
35single strand break repair (GO:0000012)3.11558016
36regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.05490951
37cilium movement (GO:0003341)3.05020456
38neuronal action potential (GO:0019228)3.01046935
39platelet dense granule organization (GO:0060155)3.00884812
40sperm-egg recognition (GO:0035036)3.00147306
41positive regulation of meiosis (GO:0045836)2.99849026
42detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.98199943
43behavioral response to nicotine (GO:0035095)2.95174439
44reciprocal DNA recombination (GO:0035825)2.94149530
45reciprocal meiotic recombination (GO:0007131)2.94149530
46neuron cell-cell adhesion (GO:0007158)2.93822716
47multicellular organism reproduction (GO:0032504)2.93485126
48spermatid nucleus differentiation (GO:0007289)2.92334621
49retrograde transport, vesicle recycling within Golgi (GO:0000301)2.91358146
50acrosome assembly (GO:0001675)2.89972428
51DNA double-strand break processing (GO:0000729)2.89385368
52positive regulation of meiotic cell cycle (GO:0051446)2.89238722
53postsynaptic membrane organization (GO:0001941)2.88716041
54protein localization to Golgi apparatus (GO:0034067)2.83925878
55presynaptic membrane organization (GO:0097090)2.83661815
56centriole replication (GO:0007099)2.79973470
57plasma membrane fusion (GO:0045026)2.79656438
58nonmotile primary cilium assembly (GO:0035058)2.76461982
59neurotransmitter-gated ion channel clustering (GO:0072578)2.75912561
60ketone body metabolic process (GO:1902224)2.75561461
61regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.73842408
62mannosylation (GO:0097502)2.73796417
63protein K11-linked deubiquitination (GO:0035871)2.72514565
64meiosis I (GO:0007127)2.71502361
65regulation of timing of cell differentiation (GO:0048505)2.71244878
66regulation of respiratory system process (GO:0044065)2.69573135
67membrane depolarization during action potential (GO:0086010)2.67647321
68somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.67126255
69isotype switching (GO:0045190)2.67126255
70somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.67126255
71motile cilium assembly (GO:0044458)2.65741203
72cytochrome complex assembly (GO:0017004)2.65344662
73glycine transport (GO:0015816)2.61424801
74photoreceptor cell maintenance (GO:0045494)2.59484707
75reflex (GO:0060004)2.58064293
76cilium organization (GO:0044782)2.57102689
77hindbrain development (GO:0030902)2.56677305
78transmission of nerve impulse (GO:0019226)2.56543476
79microtubule polymerization or depolymerization (GO:0031109)2.55961419
80cilium assembly (GO:0042384)2.53050691
81DNA deamination (GO:0045006)2.52661664
82respiratory chain complex IV assembly (GO:0008535)2.52146699
83organic cation transport (GO:0015695)2.51793169
84negative regulation of reactive oxygen species metabolic process (GO:2000378)2.51467190
85cell-cell recognition (GO:0009988)2.51348494
86male gamete generation (GO:0048232)2.50964639
87spermatogenesis (GO:0007283)2.50618361
88regulation of nuclear cell cycle DNA replication (GO:0033262)2.50454159
89GTP biosynthetic process (GO:0006183)2.49830324
90detection of mechanical stimulus involved in sensory perception (GO:0050974)2.49775071
91brain morphogenesis (GO:0048854)2.49149212
92negative regulation of DNA-dependent DNA replication (GO:2000104)2.45266248
93auditory receptor cell stereocilium organization (GO:0060088)2.41685821
94phosphate ion homeostasis (GO:0055062)2.41499562
95trivalent inorganic anion homeostasis (GO:0072506)2.41499562
96inner ear receptor stereocilium organization (GO:0060122)2.39599623
97nephron tubule morphogenesis (GO:0072078)2.39532349
98nephron epithelium morphogenesis (GO:0072088)2.39532349
99regulation of male gonad development (GO:2000018)2.39091596
100proline transport (GO:0015824)2.37406206

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.08612315
2IGF1R_20145208_ChIP-Seq_DFB_Human3.01179073
3EZH2_22144423_ChIP-Seq_EOC_Human2.84794864
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.82053871
5GBX2_23144817_ChIP-Seq_PC3_Human2.68021954
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.66353619
7FUS_26573619_Chip-Seq_HEK293_Human2.63936040
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.47909486
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.47536575
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.41132222
11VDR_22108803_ChIP-Seq_LS180_Human2.33422894
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.16076416
13PCGF2_27294783_Chip-Seq_ESCs_Mouse2.15709329
14ER_23166858_ChIP-Seq_MCF-7_Human2.13447048
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.12338325
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.11983795
17CTBP1_25329375_ChIP-Seq_LNCAP_Human2.11131327
18AR_21572438_ChIP-Seq_LNCaP_Human1.96219243
19EWS_26573619_Chip-Seq_HEK293_Human1.89998432
20PCGF2_27294783_Chip-Seq_NPCs_Mouse1.86194467
21P300_19829295_ChIP-Seq_ESCs_Human1.80862289
22IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.74039059
23CBP_20019798_ChIP-Seq_JUKART_Human1.74039059
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.72266066
25TAF15_26573619_Chip-Seq_HEK293_Human1.71954244
26SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.64820329
27IRF1_19129219_ChIP-ChIP_H3396_Human1.64371055
28EZH2_27294783_Chip-Seq_NPCs_Mouse1.63027249
29TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62819033
30POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.62819033
31SUZ12_27294783_Chip-Seq_NPCs_Mouse1.61461880
32SMAD3_21741376_ChIP-Seq_EPCs_Human1.57288965
33UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.57091412
34NFE2_27457419_Chip-Seq_LIVER_Mouse1.56989320
35SMAD4_21799915_ChIP-Seq_A2780_Human1.56892398
36NOTCH1_21737748_ChIP-Seq_TLL_Human1.55817873
37KLF5_20875108_ChIP-Seq_MESCs_Mouse1.50582610
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.48673171
39EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.48552359
40PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.47891320
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.47658112
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46209049
43STAT3_23295773_ChIP-Seq_U87_Human1.45037941
44NANOG_18555785_Chip-Seq_ESCs_Mouse1.44899662
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43482333
46TCF4_23295773_ChIP-Seq_U87_Human1.43298243
47AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.42913399
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.42323773
49GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.41601952
50TP53_22573176_ChIP-Seq_HFKS_Human1.39898522
51TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.39655214
52MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37335914
53AR_25329375_ChIP-Seq_VCAP_Human1.37158846
54NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.34688425
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34564984
56RUNX2_22187159_ChIP-Seq_PCA_Human1.31302129
57EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.30653293
58EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.30613471
59SMAD4_21741376_ChIP-Seq_EPCs_Human1.30088308
60REST_21632747_ChIP-Seq_MESCs_Mouse1.29934192
61P53_22387025_ChIP-Seq_ESCs_Mouse1.29303201
62CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.26873582
63FOXA1_27270436_Chip-Seq_PROSTATE_Human1.25364667
64FOXA1_25329375_ChIP-Seq_VCAP_Human1.25364667
65STAT3_18555785_Chip-Seq_ESCs_Mouse1.24371536
66P300_18555785_Chip-Seq_ESCs_Mouse1.24073874
67FOXA1_21572438_ChIP-Seq_LNCaP_Human1.23177244
68E2F1_18555785_Chip-Seq_ESCs_Mouse1.22276236
69CRX_20693478_ChIP-Seq_RETINA_Mouse1.18465981
70HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.18207215
71NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17459846
72NANOG_19829295_ChIP-Seq_ESCs_Human1.16928216
73SOX2_19829295_ChIP-Seq_ESCs_Human1.16928216
74BCAT_22108803_ChIP-Seq_LS180_Human1.16448058
75TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16343637
76PRDM14_20953172_ChIP-Seq_ESCs_Human1.14999131
77KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.14677755
78MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14503573
79EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.12860141
80OCT4_21477851_ChIP-Seq_ESCs_Mouse1.12805021
81RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.12493046
82SUZ12_18555785_Chip-Seq_ESCs_Mouse1.12408752
83CDX2_22108803_ChIP-Seq_LS180_Human1.12376616
84CMYC_18555785_Chip-Seq_ESCs_Mouse1.11771903
85OCT4_18555785_Chip-Seq_ESCs_Mouse1.09925425
86TCF4_22108803_ChIP-Seq_LS180_Human1.08698134
87NCOR_22424771_ChIP-Seq_293T_Human1.08584849
88ETV1_20927104_ChIP-Seq_GIST48_Human1.05294078
89ETV2_25802403_ChIP-Seq_MESCs_Mouse1.04499894
90SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.03936054
91GATA3_21878914_ChIP-Seq_MCF-7_Human1.03766503
92MYC_19829295_ChIP-Seq_ESCs_Human1.02767305
93TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01598824
94SOX2_18555785_Chip-Seq_ESCs_Mouse1.00881927
95FLI1_21867929_ChIP-Seq_TH2_Mouse1.00654989
96NMYC_18555785_Chip-Seq_ESCs_Mouse0.99924391
97SOX2_21211035_ChIP-Seq_LN229_Gbm0.99895377
98HOXB7_26014856_ChIP-Seq_BT474_Human0.99412043
99RNF2_27304074_Chip-Seq_NSC_Mouse0.99409175
100DROSHA_22980978_ChIP-Seq_HELA_Human0.98751204

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.14376177
2MP0005410_abnormal_fertilization3.43796415
3MP0002102_abnormal_ear_morphology3.20705009
4MP0001968_abnormal_touch/_nociception3.19029024
5MP0006292_abnormal_olfactory_placode2.76810165
6MP0002736_abnormal_nociception_after2.42826920
7MP0008877_abnormal_DNA_methylation2.28442919
8MP0001529_abnormal_vocalization2.13700273
9MP0002234_abnormal_pharynx_morphology2.10271266
10MP0005075_abnormal_melanosome_morpholog1.99614693
11MP0003646_muscle_fatigue1.98205906
12MP0008872_abnormal_physiological_respon1.97871754
13MP0005423_abnormal_somatic_nervous1.91261899
14MP0003880_abnormal_central_pattern1.90896776
15MP0005646_abnormal_pituitary_gland1.90672873
16MP0001984_abnormal_olfaction1.88481183
17MP0003698_abnormal_male_reproductive1.87616656
18MP0004885_abnormal_endolymph1.85941049
19MP0005551_abnormal_eye_electrophysiolog1.83781115
20MP0004270_analgesia1.81048747
21MP0008875_abnormal_xenobiotic_pharmacok1.74074117
22MP0003195_calcinosis1.72413406
23MP0001929_abnormal_gametogenesis1.68957526
24MP0001486_abnormal_startle_reflex1.67446807
25MP0000566_synostosis1.65802331
26MP0002272_abnormal_nervous_system1.61087307
27MP0006072_abnormal_retinal_apoptosis1.56791891
28MP0002837_dystrophic_cardiac_calcinosis1.56402275
29MP0004742_abnormal_vestibular_system1.52406812
30MP0009745_abnormal_behavioral_response1.51555604
31MP0009046_muscle_twitch1.48879293
32MP0002733_abnormal_thermal_nociception1.45482577
33MP0009780_abnormal_chondrocyte_physiolo1.45197438
34MP0001501_abnormal_sleep_pattern1.43477348
35MP0005379_endocrine/exocrine_gland_phen1.41514538
36MP0008058_abnormal_DNA_repair1.39355774
37MP0003878_abnormal_ear_physiology1.38182381
38MP0005377_hearing/vestibular/ear_phenot1.38182381
39MP0002734_abnormal_mechanical_nocicepti1.37413597
40MP0000631_abnormal_neuroendocrine_gland1.36695250
41MP0002138_abnormal_hepatobiliary_system1.35015600
42MP0000372_irregular_coat_pigmentation1.30922867
43MP0002735_abnormal_chemical_nociception1.27920649
44MP0004924_abnormal_behavior1.26197133
45MP0005386_behavior/neurological_phenoty1.26197133
46MP0004043_abnormal_pH_regulation1.25300554
47MP0003635_abnormal_synaptic_transmissio1.22708195
48MP0002210_abnormal_sex_determination1.22653824
49MP0002572_abnormal_emotion/affect_behav1.20453577
50MP0001905_abnormal_dopamine_level1.18781976
51MP0008995_early_reproductive_senescence1.18191626
52MP0005253_abnormal_eye_physiology1.17429835
53MP0000013_abnormal_adipose_tissue1.15070000
54MP0001970_abnormal_pain_threshold1.12958375
55MP0002184_abnormal_innervation1.11495472
56MP0000653_abnormal_sex_gland1.11462255
57MP0003567_abnormal_fetal_cardiomyocyte1.10431753
58MP0001145_abnormal_male_reproductive1.09473581
59MP0002067_abnormal_sensory_capabilities1.08537291
60MP0006035_abnormal_mitochondrial_morpho1.08193360
61MP0008789_abnormal_olfactory_epithelium1.06133749
62MP0002064_seizures1.04265443
63MP0005220_abnormal_exocrine_pancreas1.03091192
64MP0004147_increased_porphyrin_level1.02978068
65MP0002095_abnormal_skin_pigmentation1.02700901
66MP0002132_abnormal_respiratory_system1.02599475
67MP0004142_abnormal_muscle_tone0.99644164
68MP0002938_white_spotting0.98396103
69MP0002160_abnormal_reproductive_system0.98040559
70MP0001188_hyperpigmentation0.98025497
71MP0001986_abnormal_taste_sensitivity0.97306244
72MP0000015_abnormal_ear_pigmentation0.96630527
73MP0003718_maternal_effect0.96401768
74MP0005636_abnormal_mineral_homeostasis0.94453730
75MP0005174_abnormal_tail_pigmentation0.94366055
76MP0005084_abnormal_gallbladder_morpholo0.92209214
77MP0005367_renal/urinary_system_phenotyp0.91977708
78MP0000516_abnormal_urinary_system0.91977708
79MP0002876_abnormal_thyroid_physiology0.91802185
80MP0002557_abnormal_social/conspecific_i0.91059896
81MP0004133_heterotaxia0.90658735
82MP0001944_abnormal_pancreas_morphology0.90628588
83MP0006276_abnormal_autonomic_nervous0.90140925
84MP0002161_abnormal_fertility/fecundity0.89797158
85MP0005645_abnormal_hypothalamus_physiol0.89251145
86MP0002063_abnormal_learning/memory/cond0.87685240
87MP0002229_neurodegeneration0.86974878
88MP0001963_abnormal_hearing_physiology0.85397134
89MP0000026_abnormal_inner_ear0.79843266
90MP0002751_abnormal_autonomic_nervous0.79688109
91MP0000427_abnormal_hair_cycle0.79430598
92MP0005389_reproductive_system_phenotype0.76452411
93MP0003786_premature_aging0.76027865
94MP0002233_abnormal_nose_morphology0.75021206
95MP0002928_abnormal_bile_duct0.73461440
96MP0005670_abnormal_white_adipose0.71429712
97MP0004145_abnormal_muscle_electrophysio0.70434717
98MP0001764_abnormal_homeostasis0.68830875
99MP0001765_abnormal_ion_homeostasis0.67932158
100MP0003252_abnormal_bile_duct0.67895353

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)5.42237331
2Absent/shortened dynein arms (HP:0200106)5.42237331
3Focal motor seizures (HP:0011153)4.28015603
4Abnormal rod and cone electroretinograms (HP:0008323)3.90974854
5Abnormal respiratory motile cilium morphology (HP:0005938)3.79490255
6Abnormal respiratory epithelium morphology (HP:0012253)3.79490255
7Abnormal ciliary motility (HP:0012262)3.70405688
8Pancreatic fibrosis (HP:0100732)3.59172700
9True hermaphroditism (HP:0010459)3.55006250
10Decreased central vision (HP:0007663)3.40751270
11Nephronophthisis (HP:0000090)3.39913344
12Abnormal respiratory motile cilium physiology (HP:0012261)3.34113439
13Hyperventilation (HP:0002883)3.16900371
14Attenuation of retinal blood vessels (HP:0007843)3.15975487
15Pancreatic cysts (HP:0001737)3.14251748
16Abnormality of the renal medulla (HP:0100957)3.10030655
17Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.94551034
18Abnormality of midbrain morphology (HP:0002418)2.89791812
19Molar tooth sign on MRI (HP:0002419)2.89791812
20Congenital stationary night blindness (HP:0007642)2.88532637
21Absent rod-and cone-mediated responses on ERG (HP:0007688)2.88294977
22Bony spicule pigmentary retinopathy (HP:0007737)2.69093082
23Stomatitis (HP:0010280)2.66651445
24Keratoconus (HP:0000563)2.63294684
25Increased corneal curvature (HP:0100692)2.63294684
26Medial flaring of the eyebrow (HP:0010747)2.61289395
27Cone-rod dystrophy (HP:0000548)2.60942410
28Hypoplasia of the thymus (HP:0000778)2.60419250
29Type II lissencephaly (HP:0007260)2.58171831
30Tubulointerstitial nephritis (HP:0001970)2.46468439
31Thyroiditis (HP:0100646)2.45367847
32Abolished electroretinogram (ERG) (HP:0000550)2.44799355
33Pendular nystagmus (HP:0012043)2.42409128
34Abnormal drinking behavior (HP:0030082)2.41668499
35Polydipsia (HP:0001959)2.41668499
36Nephrogenic diabetes insipidus (HP:0009806)2.38514311
37Azoospermia (HP:0000027)2.32223823
38Chronic hepatic failure (HP:0100626)2.29212458
39Hemiparesis (HP:0001269)2.28845247
40Febrile seizures (HP:0002373)2.27241201
41Gait imbalance (HP:0002141)2.26727242
42Aplasia/Hypoplasia of the tongue (HP:0010295)2.25959225
43Abnormality of the renal cortex (HP:0011035)2.25888694
44Widely spaced teeth (HP:0000687)2.22442655
45Male pseudohermaphroditism (HP:0000037)2.22159699
46Focal seizures (HP:0007359)2.19546743
47Severe combined immunodeficiency (HP:0004430)2.16634563
48Decreased electroretinogram (ERG) amplitude (HP:0000654)2.15388134
49Congenital primary aphakia (HP:0007707)2.13757953
50Cystic liver disease (HP:0006706)2.09696153
51Gaze-evoked nystagmus (HP:0000640)2.09660677
52Volvulus (HP:0002580)2.08843683
53Hypothermia (HP:0002045)2.07192302
54Methylmalonic acidemia (HP:0002912)2.00933835
55Postaxial foot polydactyly (HP:0001830)1.99764216
56Genital tract atresia (HP:0001827)1.98080600
57Dialeptic seizures (HP:0011146)1.96335300
58Broad-based gait (HP:0002136)1.96105089
59Polyuria (HP:0000103)1.94561089
60Arthropathy (HP:0003040)1.93576647
61Tubulointerstitial abnormality (HP:0001969)1.93147241
62Lissencephaly (HP:0001339)1.92972047
63Intestinal atresia (HP:0011100)1.91873636
64Abnormal spermatogenesis (HP:0008669)1.89670820
65Rhinitis (HP:0012384)1.88408799
66Sclerocornea (HP:0000647)1.84726396
67Congenital hepatic fibrosis (HP:0002612)1.84363161
68Amelogenesis imperfecta (HP:0000705)1.84027142
69Drooling (HP:0002307)1.84008090
70Hypoproteinemia (HP:0003075)1.83080875
71Abnormal urine output (HP:0012590)1.82619689
72Poor eye contact (HP:0000817)1.82063526
73Chronic bronchitis (HP:0004469)1.82056175
74Bronchiectasis (HP:0002110)1.81652767
75Absence seizures (HP:0002121)1.75430893
76Abnormality of macular pigmentation (HP:0008002)1.74720883
77Colon cancer (HP:0003003)1.74669176
78Abnormality of the labia minora (HP:0012880)1.73357261
79Abnormality of B cell number (HP:0010975)1.72589064
80Type 2 muscle fiber atrophy (HP:0003554)1.70858327
81Panhypogammaglobulinemia (HP:0003139)1.70776856
82Median cleft lip (HP:0000161)1.70652379
83Specific learning disability (HP:0001328)1.69717516
84Retinitis pigmentosa (HP:0000510)1.69646284
85Ketoacidosis (HP:0001993)1.68954180
86Hypokalemic alkalosis (HP:0001949)1.68836907
87Chorioretinal atrophy (HP:0000533)1.67878010
88Cerebellar dysplasia (HP:0007033)1.67447878
89Infertility (HP:0000789)1.67283973
90Severe visual impairment (HP:0001141)1.67177365
91B lymphocytopenia (HP:0010976)1.66981417
92Vaginal atresia (HP:0000148)1.66360353
93Abnormality of endocrine pancreas physiology (HP:0012093)1.65206876
94Abnormality of the pancreatic islet cells (HP:0006476)1.65206876
95Postaxial hand polydactyly (HP:0001162)1.64161264
96Excessive salivation (HP:0003781)1.62539314
97Tubular atrophy (HP:0000092)1.62507566
98Abnormality of renal excretion (HP:0011036)1.60882332
99Fair hair (HP:0002286)1.60845305
100Polyphagia (HP:0002591)1.60703139

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K24.90836837
2PNCK3.58336054
3TNIK3.47598974
4FRK3.46600000
5WNK43.33981446
6TAF12.59581634
7NUAK12.42619096
8STK392.30555151
9NTRK32.27487265
10OXSR12.06396270
11MAPK131.90529069
12TAOK11.80683671
13CASK1.79112293
14PLK41.79064621
15BMPR1B1.77221031
16PINK11.67733553
17PLK21.65330455
18ZAK1.62841975
19TAOK31.61780606
20ADRBK21.58661036
21NTRK21.52494380
22STK38L1.48832538
23PHKG21.42319874
24PHKG11.42319874
25MST41.42017010
26MAP2K61.40486408
27MARK11.39302803
28BRD41.36772336
29TNK21.36358499
30GRK11.36188504
31VRK21.31031608
32WNK31.30734516
33NLK1.24557512
34ERBB31.18945793
35DAPK21.16500802
36INSRR1.09874668
37MAPKAPK31.01615394
38TLK10.95296204
39MAPK150.93703462
40WNK10.93693870
41FGFR20.93613637
42EIF2AK30.92743696
43DYRK20.90460699
44CDK30.85690370
45CLK10.81306988
46MAP3K40.79677711
47NME10.78083215
48MUSK0.77106381
49VRK10.73904345
50MATK0.70999630
51MKNK20.70927072
52CDK190.69981016
53FES0.69092888
54CAMK1G0.67822547
55NTRK10.65203601
56PRKCQ0.62232107
57SIK20.62187076
58TRPM70.62030666
59OBSCN0.58469467
60MAP2K70.57772004
61CSNK1G10.57090803
62PRKCG0.56899443
63STK110.55331480
64PLK30.54746045
65PAK30.53001514
66MAPKAPK50.52080857
67PRKCE0.50695172
68RPS6KB10.46783087
69MKNK10.46469060
70PRKG10.45810293
71CSNK1G20.45100379
72TEC0.44407449
73CAMK10.43292157
74SGK10.42902011
75ADRBK10.42243370
76ATM0.42093912
77KIT0.41806692
78CSNK1G30.40424493
79TYRO30.38512149
80STK30.37708799
81CSNK1D0.36959164
82EPHA40.36489021
83MAP3K20.35847102
84SGK20.35805647
85WEE10.35771627
86CSNK1E0.35757022
87TGFBR20.35570798
88PLK10.33960315
89FGFR30.33516732
90PKN10.32792686
91IKBKB0.31825136
92RPS6KA40.31591197
93DYRK1A0.31563183
94UHMK10.30632252
95CSNK1A10.30127279
96PIK3CG0.30122828
97GRK50.29801974
98MINK10.29532727
99LATS10.29011041
100PRKACA0.28992145

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.36628441
2Phototransduction_Homo sapiens_hsa047443.10944711
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.64271007
4Olfactory transduction_Homo sapiens_hsa047402.51225772
5Asthma_Homo sapiens_hsa053102.25368479
6Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.20948931
7Basal transcription factors_Homo sapiens_hsa030222.06958251
8Nicotine addiction_Homo sapiens_hsa050331.96536215
9Fanconi anemia pathway_Homo sapiens_hsa034601.94147792
10Butanoate metabolism_Homo sapiens_hsa006501.93483338
11Homologous recombination_Homo sapiens_hsa034401.87416842
12Allograft rejection_Homo sapiens_hsa053301.86167831
13Type I diabetes mellitus_Homo sapiens_hsa049401.79679302
14One carbon pool by folate_Homo sapiens_hsa006701.76333729
15Linoleic acid metabolism_Homo sapiens_hsa005911.75790552
16RNA polymerase_Homo sapiens_hsa030201.74840665
17Autoimmune thyroid disease_Homo sapiens_hsa053201.72373761
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.70286597
19Taste transduction_Homo sapiens_hsa047421.66796794
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.64115007
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.55225395
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.54415420
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.54112501
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.51662469
25Primary immunodeficiency_Homo sapiens_hsa053401.50411172
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.45785734
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.42163915
28Salivary secretion_Homo sapiens_hsa049701.33148264
29Propanoate metabolism_Homo sapiens_hsa006401.31853301
30Nitrogen metabolism_Homo sapiens_hsa009101.31203048
31Vitamin B6 metabolism_Homo sapiens_hsa007501.29465864
32Caffeine metabolism_Homo sapiens_hsa002321.28429829
33RNA degradation_Homo sapiens_hsa030181.24234445
34RNA transport_Homo sapiens_hsa030131.22143508
35Non-homologous end-joining_Homo sapiens_hsa034501.16884654
36Regulation of autophagy_Homo sapiens_hsa041401.14621998
37Purine metabolism_Homo sapiens_hsa002301.14046987
38Renin secretion_Homo sapiens_hsa049241.13857618
39Selenocompound metabolism_Homo sapiens_hsa004501.13479964
40Dorso-ventral axis formation_Homo sapiens_hsa043201.10370229
41Glutamatergic synapse_Homo sapiens_hsa047241.10163444
42Ether lipid metabolism_Homo sapiens_hsa005651.09842814
43Chemical carcinogenesis_Homo sapiens_hsa052041.09610355
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.06756236
45Graft-versus-host disease_Homo sapiens_hsa053321.06584867
46Circadian entrainment_Homo sapiens_hsa047131.06438011
47Mismatch repair_Homo sapiens_hsa034301.05023244
48Tryptophan metabolism_Homo sapiens_hsa003801.03063296
49Protein export_Homo sapiens_hsa030601.00072230
50Insulin secretion_Homo sapiens_hsa049110.97068103
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.94313147
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.92364038
53Morphine addiction_Homo sapiens_hsa050320.87083334
54Oxidative phosphorylation_Homo sapiens_hsa001900.86845393
55Fatty acid biosynthesis_Homo sapiens_hsa000610.84609320
56Arachidonic acid metabolism_Homo sapiens_hsa005900.84406889
57Retinol metabolism_Homo sapiens_hsa008300.83431528
58Peroxisome_Homo sapiens_hsa041460.80413648
59mRNA surveillance pathway_Homo sapiens_hsa030150.79714555
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79020403
61Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.78829279
62Proteasome_Homo sapiens_hsa030500.76695992
63Calcium signaling pathway_Homo sapiens_hsa040200.74466000
64Serotonergic synapse_Homo sapiens_hsa047260.72891809
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72743772
66Nucleotide excision repair_Homo sapiens_hsa034200.69447482
67Long-term depression_Homo sapiens_hsa047300.68735662
68Collecting duct acid secretion_Homo sapiens_hsa049660.66612184
69GABAergic synapse_Homo sapiens_hsa047270.65864639
70Cardiac muscle contraction_Homo sapiens_hsa042600.65599839
71Fatty acid elongation_Homo sapiens_hsa000620.64181708
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63204307
73Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.62575670
74Amphetamine addiction_Homo sapiens_hsa050310.62092618
75Steroid biosynthesis_Homo sapiens_hsa001000.61449843
76Huntingtons disease_Homo sapiens_hsa050160.60039663
77Antigen processing and presentation_Homo sapiens_hsa046120.58410312
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.54981856
79Dopaminergic synapse_Homo sapiens_hsa047280.54475204
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.53961547
81ABC transporters_Homo sapiens_hsa020100.53221107
82Fat digestion and absorption_Homo sapiens_hsa049750.52146611
83Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51325094
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48634686
85Rheumatoid arthritis_Homo sapiens_hsa053230.47311948
86NOD-like receptor signaling pathway_Homo sapiens_hsa046210.46775736
87Long-term potentiation_Homo sapiens_hsa047200.45202550
88Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.45127598
89Spliceosome_Homo sapiens_hsa030400.44473717
90Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44051933
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43913181
92cAMP signaling pathway_Homo sapiens_hsa040240.42360856
93Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.42137013
94Sphingolipid metabolism_Homo sapiens_hsa006000.42053833
95Metabolic pathways_Homo sapiens_hsa011000.41386348
96Oocyte meiosis_Homo sapiens_hsa041140.40921377
97Fatty acid degradation_Homo sapiens_hsa000710.40784635
98Oxytocin signaling pathway_Homo sapiens_hsa049210.39819739
99Type II diabetes mellitus_Homo sapiens_hsa049300.39361989
100Fatty acid metabolism_Homo sapiens_hsa012120.38630623

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