NPIPA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome reaction (GO:0007340)6.37517326
2protein K11-linked deubiquitination (GO:0035871)6.26982156
3sperm motility (GO:0030317)6.02095081
4single strand break repair (GO:0000012)5.38174233
5fusion of sperm to egg plasma membrane (GO:0007342)4.88582933
6organic cation transport (GO:0015695)4.80571180
7establishment of protein localization to Golgi (GO:0072600)4.69289709
8piRNA metabolic process (GO:0034587)4.68877259
9response to pheromone (GO:0019236)4.67565566
10microtubule depolymerization (GO:0007019)4.65874256
11spermatid development (GO:0007286)4.65551718
12seminiferous tubule development (GO:0072520)4.58710084
13protein polyglutamylation (GO:0018095)4.52190253
14regulation of centriole replication (GO:0046599)4.49242685
15regulation of meiosis I (GO:0060631)4.36812286
16microtubule polymerization or depolymerization (GO:0031109)4.36018794
17centriole replication (GO:0007099)4.35633581
18protein targeting to Golgi (GO:0000042)4.29165567
19DNA double-strand break processing (GO:0000729)4.23994506
20serotonin receptor signaling pathway (GO:0007210)4.19819350
21rRNA methylation (GO:0031167)4.15804009
22rRNA modification (GO:0000154)4.15498275
23sperm-egg recognition (GO:0035036)3.91340729
24retrograde transport, vesicle recycling within Golgi (GO:0000301)3.75589965
25plasma membrane fusion (GO:0045026)3.67859209
26regulation of cilium movement (GO:0003352)3.65976607
27centriole assembly (GO:0098534)3.58203472
28regulation of appetite (GO:0032098)3.57334037
29coenzyme catabolic process (GO:0009109)3.56190283
30binding of sperm to zona pellucida (GO:0007339)3.49544750
31hematopoietic stem cell proliferation (GO:0071425)3.49338694
32synapsis (GO:0007129)3.48833463
33chromosome condensation (GO:0030261)3.43422005
34replication fork processing (GO:0031297)3.42247658
35sperm capacitation (GO:0048240)3.40518696
36protein sumoylation (GO:0016925)3.39609401
37DNA packaging (GO:0006323)3.39135004
38spermatogenesis (GO:0007283)3.37801093
39male gamete generation (GO:0048232)3.37309240
40cilium or flagellum-dependent cell motility (GO:0001539)3.35238652
41cellular ketone body metabolic process (GO:0046950)3.32734085
42male meiosis (GO:0007140)3.30961027
43negative regulation of interleukin-8 production (GO:0032717)3.26395487
44protein localization to Golgi apparatus (GO:0034067)3.23161633
45calcium ion-dependent exocytosis (GO:0017156)3.20669641
46spermatid nucleus differentiation (GO:0007289)3.16432624
47multicellular organism reproduction (GO:0032504)3.15245603
48negative regulation of circadian rhythm (GO:0042754)3.15041732
49gamete generation (GO:0007276)3.12622914
50ketone body metabolic process (GO:1902224)3.10084702
51cell-cell recognition (GO:0009988)3.04781886
52axonemal dynein complex assembly (GO:0070286)3.02106516
53sulfation (GO:0051923)2.99950544
54DNA methylation involved in gamete generation (GO:0043046)2.98334989
55nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.97330969
56carnitine transmembrane transport (GO:1902603)2.97305342
57single fertilization (GO:0007338)2.95827307
58germ cell development (GO:0007281)2.95748837
59glycerol ether metabolic process (GO:0006662)2.94108234
60negative regulation of metanephros development (GO:0072217)2.93356152
61resolution of meiotic recombination intermediates (GO:0000712)2.91789967
62detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.89834560
63exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.87694859
64negative regulation of DNA-dependent DNA replication (GO:2000104)2.86403187
65male meiosis I (GO:0007141)2.86230275
66maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.84935080
67meiotic cell cycle (GO:0051321)2.84760702
68regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.82718700
69lymphangiogenesis (GO:0001946)2.82546487
70epithelial cilium movement (GO:0003351)2.81527771
71protein-cofactor linkage (GO:0018065)2.81453885
72negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.81097362
73regulation of penile erection (GO:0060405)2.81057101
74ether metabolic process (GO:0018904)2.74107239
75histone exchange (GO:0043486)2.74081373
76positive regulation of digestive system process (GO:0060456)2.67866235
77carnitine transport (GO:0015879)2.66921253
78amino-acid betaine transport (GO:0015838)2.66921253
79intra-S DNA damage checkpoint (GO:0031573)2.64454935
80cysteine metabolic process (GO:0006534)2.64237198
81negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.59891217
82detection of light stimulus involved in sensory perception (GO:0050962)2.58656171
83detection of light stimulus involved in visual perception (GO:0050908)2.58656171
84DNA integration (GO:0015074)2.58585559
85fertilization (GO:0009566)2.58138921
86motile cilium assembly (GO:0044458)2.57924149
87reproduction (GO:0000003)2.56402403
88regulation of sarcomere organization (GO:0060297)2.55657768
89RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.55015629
90tryptophan catabolic process (GO:0006569)2.54920137
91indole-containing compound catabolic process (GO:0042436)2.54920137
92indolalkylamine catabolic process (GO:0046218)2.54920137
93gene silencing by RNA (GO:0031047)2.54837668
94regulation of Cdc42 GTPase activity (GO:0043088)2.54311243
95nephron tubule morphogenesis (GO:0072078)2.53669481
96nephron epithelium morphogenesis (GO:0072088)2.53669481
97histone mRNA catabolic process (GO:0071044)2.53382308
98sex differentiation (GO:0007548)2.53203656
99proteasome assembly (GO:0043248)2.49986798
100mannosylation (GO:0097502)2.49036289

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.62953934
2GBX2_23144817_ChIP-Seq_PC3_Human3.44789809
3IGF1R_20145208_ChIP-Seq_DFB_Human3.14273996
4FUS_26573619_Chip-Seq_HEK293_Human2.94370479
5TAF15_26573619_Chip-Seq_HEK293_Human2.57006162
6CTBP2_25329375_ChIP-Seq_LNCAP_Human2.55659811
7CTBP1_25329375_ChIP-Seq_LNCAP_Human2.54699191
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.51328440
9IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.20177267
10CBP_20019798_ChIP-Seq_JUKART_Human2.20177267
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.19069606
12EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.14172945
13ER_23166858_ChIP-Seq_MCF-7_Human2.08678472
14VDR_22108803_ChIP-Seq_LS180_Human2.08566261
15P300_19829295_ChIP-Seq_ESCs_Human2.08533771
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.03058807
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.02257773
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.00645246
19EWS_26573619_Chip-Seq_HEK293_Human2.00593729
20UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.94650262
21SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.93115763
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.92466743
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.90998904
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.88899754
25EST1_17652178_ChIP-ChIP_JURKAT_Human1.84737134
26AR_25329375_ChIP-Seq_VCAP_Human1.74558488
27GABP_17652178_ChIP-ChIP_JURKAT_Human1.72321332
28SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.71982492
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.68168870
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57607721
31E2F7_22180533_ChIP-Seq_HELA_Human1.57340992
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56032776
33KLF5_20875108_ChIP-Seq_MESCs_Mouse1.55334006
34SMAD3_21741376_ChIP-Seq_EPCs_Human1.48724380
35SMAD4_21741376_ChIP-Seq_EPCs_Human1.47632532
36MYC_18940864_ChIP-ChIP_HL60_Human1.46558757
37SMAD4_21799915_ChIP-Seq_A2780_Human1.44610495
38FOXA1_27270436_Chip-Seq_PROSTATE_Human1.42127883
39FOXA1_25329375_ChIP-Seq_VCAP_Human1.42127883
40STAT3_23295773_ChIP-Seq_U87_Human1.41069133
41EZH2_22144423_ChIP-Seq_EOC_Human1.40093073
42GATA1_26923725_Chip-Seq_HPCs_Mouse1.39024603
43IKZF1_21737484_ChIP-ChIP_HCT116_Human1.37608872
44RUNX2_22187159_ChIP-Seq_PCA_Human1.36898661
45TP53_22573176_ChIP-Seq_HFKS_Human1.35508861
46TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34083267
47AUTS2_25519132_ChIP-Seq_293T-REX_Human1.32372943
48RBPJ_22232070_ChIP-Seq_NCS_Mouse1.29834783
49E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.28689358
50FOXA1_21572438_ChIP-Seq_LNCaP_Human1.28362829
51PHF8_20622853_ChIP-Seq_HELA_Human1.28063008
52TCF4_23295773_ChIP-Seq_U87_Human1.27732792
53GATA3_21878914_ChIP-Seq_MCF-7_Human1.26882583
54E2F4_17652178_ChIP-ChIP_JURKAT_Human1.26801595
55TCF4_22108803_ChIP-Seq_LS180_Human1.26326620
56SOX2_19829295_ChIP-Seq_ESCs_Human1.24563006
57NANOG_19829295_ChIP-Seq_ESCs_Human1.24563006
58ERG_20517297_ChIP-Seq_VCAP_Human1.23212497
59WDR5_24793694_ChIP-Seq_LNCAP_Human1.21477500
60GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21474605
61TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18987370
62POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18987370
63EZH2_27294783_Chip-Seq_NPCs_Mouse1.18911462
64NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.18677738
65CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.18341912
66AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18230626
67RBPJ_21746931_ChIP-Seq_IB4_Human1.17626649
68VDR_23849224_ChIP-Seq_CD4+_Human1.15739395
69FLI1_21867929_ChIP-Seq_TH2_Mouse1.15081861
70TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14244798
71SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13975896
72ERA_21632823_ChIP-Seq_H3396_Human1.12154360
73IRF1_19129219_ChIP-ChIP_H3396_Human1.11451832
74NFYB_21822215_ChIP-Seq_K562_Human1.10567582
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.10209791
76NCOR_22424771_ChIP-Seq_293T_Human1.07292177
77MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07235845
78MYC_19829295_ChIP-Seq_ESCs_Human1.07138421
79LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06990854
80PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.06990845
81HNFA_21074721_ChIP-Seq_CACO-2_Human1.05849320
82CBX2_22325352_ChIP-Seq_293T-Rex_Human1.05707900
83ETV1_20927104_ChIP-Seq_GIST48_Human1.05541822
84RNF2_27304074_Chip-Seq_NSC_Mouse1.05467654
85TBL1_22424771_ChIP-Seq_293T_Human1.05419519
86HOXB7_26014856_ChIP-Seq_BT474_Human1.05239117
87FOXP3_21729870_ChIP-Seq_TREG_Human1.04613513
88CDX2_22108803_ChIP-Seq_LS180_Human1.04407623
89TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.03354425
90ETV2_25802403_ChIP-Seq_MESCs_Mouse1.03185690
91PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03114134
92CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.02255771
93JUN_21703547_ChIP-Seq_K562_Human1.02132456
94NANOG_20526341_ChIP-Seq_ESCs_Human1.00736826
95JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.00432289
96AR_20517297_ChIP-Seq_VCAP_Human1.00313036
97BCAT_22108803_ChIP-Seq_LS180_Human1.00083652
98EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.99494489
99GATA6_21074721_ChIP-Seq_CACO-2_Human0.99060470
100MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.98795277

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization4.78437690
2MP0002254_reproductive_system_inflammat3.47577943
3MP0005084_abnormal_gallbladder_morpholo2.82491599
4MP0005670_abnormal_white_adipose2.77436529
5MP0001529_abnormal_vocalization2.71906879
6MP0002138_abnormal_hepatobiliary_system2.65113197
7MP0003718_maternal_effect2.63497124
8MP0005377_hearing/vestibular/ear_phenot2.62197683
9MP0003878_abnormal_ear_physiology2.62197683
10MP0003806_abnormal_nucleotide_metabolis2.53474285
11MP0001984_abnormal_olfaction2.52844465
12MP0003698_abnormal_male_reproductive2.41237527
13MP0008058_abnormal_DNA_repair2.40673575
14MP0008877_abnormal_DNA_methylation2.33778383
15MP0001929_abnormal_gametogenesis2.27230358
16MP0002735_abnormal_chemical_nociception2.13331152
17MP0000372_irregular_coat_pigmentation2.02289439
18MP0001968_abnormal_touch/_nociception1.90588452
19MP0003646_muscle_fatigue1.89835804
20MP0002736_abnormal_nociception_after1.84663015
21MP0002102_abnormal_ear_morphology1.84179397
22MP0006276_abnormal_autonomic_nervous1.81344732
23MP0003183_abnormal_peptide_metabolism1.77549646
24MP0004957_abnormal_blastocyst_morpholog1.74483442
25MP0005551_abnormal_eye_electrophysiolog1.66451835
26MP0002210_abnormal_sex_determination1.66234969
27MP0005310_abnormal_salivary_gland1.57096780
28MP0010094_abnormal_chromosome_stability1.56760167
29MP0002822_catalepsy1.51652702
30MP0009697_abnormal_copulation1.44169864
31MP0008875_abnormal_xenobiotic_pharmacok1.39668625
32MP0001145_abnormal_male_reproductive1.39381272
33MP0006292_abnormal_olfactory_placode1.36860941
34MP0005083_abnormal_biliary_tract1.36481790
35MP0001486_abnormal_startle_reflex1.36121740
36MP0008995_early_reproductive_senescence1.35887785
37MP0000653_abnormal_sex_gland1.33562845
38MP0002161_abnormal_fertility/fecundity1.30522114
39MP0009745_abnormal_behavioral_response1.27210697
40MP0003880_abnormal_central_pattern1.26012502
41MP0001348_abnormal_lacrimal_gland1.25259526
42MP0009046_muscle_twitch1.22596492
43MP0005253_abnormal_eye_physiology1.17541782
44MP0001485_abnormal_pinna_reflex1.17473571
45MP0000613_abnormal_salivary_gland1.15694975
46MP0002938_white_spotting1.14290581
47MP0003136_yellow_coat_color1.13352651
48MP0003693_abnormal_embryo_hatching1.08923435
49MP0003567_abnormal_fetal_cardiomyocyte1.06114309
50MP0002572_abnormal_emotion/affect_behav1.05857298
51MP0005389_reproductive_system_phenotype1.05320075
52MP0000383_abnormal_hair_follicle1.03117083
53MP0003011_delayed_dark_adaptation1.00749693
54MP0005187_abnormal_penis_morphology0.99999183
55MP0001293_anophthalmia0.99247552
56MP0002734_abnormal_mechanical_nocicepti0.97633040
57MP0002272_abnormal_nervous_system0.96147330
58MP0002160_abnormal_reproductive_system0.95466117
59MP0003077_abnormal_cell_cycle0.93853389
60MP0001970_abnormal_pain_threshold0.93156875
61MP0006035_abnormal_mitochondrial_morpho0.92811230
62MP0001919_abnormal_reproductive_system0.92154575
63MP0001905_abnormal_dopamine_level0.91023498
64MP0000230_abnormal_systemic_arterial0.89968466
65MP0000516_abnormal_urinary_system0.89310181
66MP0005367_renal/urinary_system_phenotyp0.89310181
67MP0000049_abnormal_middle_ear0.88642730
68MP0002928_abnormal_bile_duct0.86590072
69MP0000569_abnormal_digit_pigmentation0.85732807
70MP0008872_abnormal_physiological_respon0.85582891
71MP0004142_abnormal_muscle_tone0.84783565
72MP0002127_abnormal_cardiovascular_syste0.83379315
73MP0003195_calcinosis0.82782133
74MP0002837_dystrophic_cardiac_calcinosis0.82651011
75MP0001324_abnormal_eye_pigmentation0.82303891
76MP0005395_other_phenotype0.82278984
77MP0001764_abnormal_homeostasis0.81976866
78MP0000631_abnormal_neuroendocrine_gland0.79986806
79MP0002733_abnormal_thermal_nociception0.76814670
80MP0002229_neurodegeneration0.75202151
81MP0001986_abnormal_taste_sensitivity0.74728761
82MP0004085_abnormal_heartbeat0.73765849
83MP0002067_abnormal_sensory_capabilities0.73032209
84MP0006072_abnormal_retinal_apoptosis0.72734800
85MP0002095_abnormal_skin_pigmentation0.71003456
86MP0008789_abnormal_olfactory_epithelium0.70720167
87MP0006036_abnormal_mitochondrial_physio0.70575891
88MP0005423_abnormal_somatic_nervous0.70178647
89MP0002064_seizures0.70163123
90MP0003936_abnormal_reproductive_system0.68678351
91MP0002557_abnormal_social/conspecific_i0.68138408
92MP0002234_abnormal_pharynx_morphology0.68004785
93MP0008932_abnormal_embryonic_tissue0.67462135
94MP0005174_abnormal_tail_pigmentation0.66741891
95MP0001879_abnormal_lymphatic_vessel0.66689266
96MP0004484_altered_response_of0.66520107
97MP0003137_abnormal_impulse_conducting0.66234282
98MP0002876_abnormal_thyroid_physiology0.65653509
99MP0003252_abnormal_bile_duct0.65538780
100MP0005647_abnormal_sex_gland0.65219615

Predicted human phenotypes

RankGene SetZ-score
1Attenuation of retinal blood vessels (HP:0007843)4.05122459
2Tubulointerstitial nephritis (HP:0001970)3.99523165
3True hermaphroditism (HP:0010459)3.58436328
4Chronic hepatic failure (HP:0100626)3.51440226
5Nephronophthisis (HP:0000090)3.36087549
6Pancreatic cysts (HP:0001737)3.31414193
7Abolished electroretinogram (ERG) (HP:0000550)3.31061968
8Bony spicule pigmentary retinopathy (HP:0007737)3.24313841
9Absent/shortened dynein arms (HP:0200106)3.22906305
10Dynein arm defect of respiratory motile cilia (HP:0012255)3.22906305
11Hyperglycinuria (HP:0003108)3.16412360
12Hyperglycinemia (HP:0002154)3.14918787
13Pancreatic fibrosis (HP:0100732)3.12045078
14Aplasia/hypoplasia of the uterus (HP:0008684)2.84178067
15Decreased electroretinogram (ERG) amplitude (HP:0000654)2.82680207
16Abnormality of the renal medulla (HP:0100957)2.67863260
17Abnormal rod and cone electroretinograms (HP:0008323)2.63961560
18Lower limb hyperreflexia (HP:0002395)2.61406532
19Severe visual impairment (HP:0001141)2.57027203
20Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.54634403
21Stage 5 chronic kidney disease (HP:0003774)2.49952206
22Hypoplasia of the uterus (HP:0000013)2.48844339
23Male pseudohermaphroditism (HP:0000037)2.45746755
24Abnormality of serine family amino acid metabolism (HP:0010894)2.44872035
25Abnormality of glycine metabolism (HP:0010895)2.44872035
26Abnormal respiratory motile cilium morphology (HP:0005938)2.42322634
27Abnormal respiratory epithelium morphology (HP:0012253)2.42322634
28Acute encephalopathy (HP:0006846)2.40664336
29Volvulus (HP:0002580)2.40376521
30Colon cancer (HP:0003003)2.38793981
31Abnormal ciliary motility (HP:0012262)2.30070064
32Abnormality of the ileum (HP:0001549)2.29996057
33Congenital sensorineural hearing impairment (HP:0008527)2.28701435
34Retinal dysplasia (HP:0007973)2.25771393
35Abnormal respiratory motile cilium physiology (HP:0012261)2.25251472
36Bilateral microphthalmos (HP:0007633)2.20728409
37Abnormality of urine glucose concentration (HP:0011016)2.19147807
38Glycosuria (HP:0003076)2.19147807
39Meckel diverticulum (HP:0002245)2.18470743
40Small hand (HP:0200055)2.18018745
41Medial flaring of the eyebrow (HP:0010747)2.17272106
42Abnormal lung lobation (HP:0002101)2.15417041
43Intestinal atresia (HP:0011100)2.14609565
44Acute necrotizing encephalopathy (HP:0006965)2.10526907
45Molar tooth sign on MRI (HP:0002419)2.10362828
46Abnormality of midbrain morphology (HP:0002418)2.10362828
47Occipital encephalocele (HP:0002085)2.10008913
48Aplasia/Hypoplasia of the uvula (HP:0010293)2.08858601
49Ependymoma (HP:0002888)2.06159750
50Congenital stationary night blindness (HP:0007642)2.02389043
51Cerebellar dysplasia (HP:0007033)2.00281511
52Abnormality of the labia minora (HP:0012880)1.98464741
53Abnormal protein glycosylation (HP:0012346)1.97487183
54Abnormal glycosylation (HP:0012345)1.97487183
55Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.97487183
56Abnormal protein N-linked glycosylation (HP:0012347)1.97487183
57Unilateral renal agenesis (HP:0000122)1.97389587
58Nephrogenic diabetes insipidus (HP:0009806)1.97007188
59Abnormal drinking behavior (HP:0030082)1.96578764
60Polydipsia (HP:0001959)1.96578764
61Abnormality of macular pigmentation (HP:0008002)1.95924606
62Genital tract atresia (HP:0001827)1.94485849
63Abnormality of serum amino acid levels (HP:0003112)1.94233786
64Hepatocellular necrosis (HP:0001404)1.93228541
65Postaxial foot polydactyly (HP:0001830)1.92896515
66Cystic liver disease (HP:0006706)1.91275912
67Sloping forehead (HP:0000340)1.91022635
68Aplasia/Hypoplasia of the tibia (HP:0005772)1.90376746
69Gastrointestinal atresia (HP:0002589)1.90249377
70Hyperkalemia (HP:0002153)1.89059424
71Gait imbalance (HP:0002141)1.88990220
72Impulsivity (HP:0100710)1.88566653
73Congenital primary aphakia (HP:0007707)1.88276549
74Absent speech (HP:0001344)1.85589822
75Aplasia/Hypoplasia of the tongue (HP:0010295)1.85101270
76Hyperventilation (HP:0002883)1.85012354
77Glioma (HP:0009733)1.84287039
78Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.84074227
79Duodenal stenosis (HP:0100867)1.81784775
80Small intestinal stenosis (HP:0012848)1.81784775
81Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.81635199
82Degeneration of the lateral corticospinal tracts (HP:0002314)1.81635199
83Abnormality of dental color (HP:0011073)1.81291675
84Increased CSF lactate (HP:0002490)1.80165279
85Confusion (HP:0001289)1.79892649
86Amelogenesis imperfecta (HP:0000705)1.78645739
87Absent rod-and cone-mediated responses on ERG (HP:0007688)1.77350438
88Optic nerve hypoplasia (HP:0000609)1.76222028
89Mitochondrial inheritance (HP:0001427)1.75309088
90Preaxial foot polydactyly (HP:0001841)1.75239234
91Pendular nystagmus (HP:0012043)1.74345303
92Hepatic necrosis (HP:0002605)1.72051335
93Type II lissencephaly (HP:0007260)1.71354355
94Vaginal atresia (HP:0000148)1.71094568
95Abnormality of chromosome stability (HP:0003220)1.69081703
96Sclerocornea (HP:0000647)1.69002323
97Aplasia/Hypoplasia involving the musculature (HP:0001460)1.68452211
98Renal Fanconi syndrome (HP:0001994)1.67504527
99Infertility (HP:0000789)1.67461010
100Chronic bronchitis (HP:0004469)1.65525564

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK45.30742574
2FRK3.97578548
3MAP4K23.90526532
4WNK33.73121958
5PBK3.08749750
6PINK12.68848206
7PLK22.59496225
8STK38L2.58070498
9ZAK2.41965159
10INSRR2.05721358
11PNCK2.05140375
12CASK1.93230126
13MAP3K41.91414354
14TRIM281.80295280
15TXK1.58568214
16EIF2AK31.58336301
17SRPK11.50278334
18WNK41.49801625
19TIE11.48139138
20TESK11.39460381
21TTK1.38111460
22CDK191.37676988
23MAP2K71.30004630
24STK391.29088999
25TAF11.28473247
26VRK21.24872069
27GRK11.24828524
28PLK31.24776699
29VRK11.20663160
30FER1.19251920
31DYRK21.11223721
32NEK11.10411245
33BCR1.09797918
34BMPR1B1.08633275
35BCKDK1.08300130
36MAP3K61.06475407
37WEE11.05704845
38MAPK131.05300877
39OXSR11.03552466
40CDC71.03278745
41ADRBK20.99691102
42MKNK10.97734698
43NME10.95785588
44RPS6KA40.94335238
45PAK30.90456542
46NUAK10.89234034
47STK380.86950923
48PLK10.84172833
49TAOK30.82427054
50TSSK60.79588750
51MAPKAPK30.77335516
52DDR20.77240045
53FLT30.74580088
54BRSK20.73401400
55MUSK0.73236395
56ACVR1B0.72432709
57CDK30.71069833
58STK160.70556294
59MST40.70234043
60CSNK1G20.66250710
61MARK10.65024943
62ERBB30.63729089
63CHEK20.59351511
64MAP2K60.56807012
65WNK10.55664706
66PRKCG0.55228349
67DYRK30.52428846
68MINK10.51340846
69ADRBK10.49323112
70CAMK1G0.48227172
71MKNK20.47875618
72PASK0.47718210
73PIK3CG0.47696180
74MAP2K40.46313572
75PRKCE0.45419164
76CSNK1G10.45237306
77LIMK10.44705772
78NEK60.42553598
79CDK70.42515492
80PRKCZ0.41969122
81CAMK10.41263517
82MAPK150.40580128
83CSNK1G30.40457168
84PRKG10.40065452
85CSNK1A10.39290633
86CAMK2A0.37601934
87MAP2K10.35532412
88ATR0.35200598
89PRKCB0.35109454
90IGF1R0.32903269
91KSR10.32214609
92ATM0.31784305
93CSNK1E0.31434014
94MAPKAPK50.31378434
95DYRK1A0.30971345
96CSNK2A10.29046447
97FGFR10.28993725
98PRKACA0.28948891
99KIT0.28758965
100YES10.28600675

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.53131600
2Proteasome_Homo sapiens_hsa030502.83713090
3Propanoate metabolism_Homo sapiens_hsa006402.65738066
4Butanoate metabolism_Homo sapiens_hsa006502.48321400
5RNA transport_Homo sapiens_hsa030132.42213241
6Selenocompound metabolism_Homo sapiens_hsa004502.40577486
7Fanconi anemia pathway_Homo sapiens_hsa034602.34181388
8DNA replication_Homo sapiens_hsa030302.11943158
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.06496140
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.03727399
11Non-homologous end-joining_Homo sapiens_hsa034502.02963942
12Base excision repair_Homo sapiens_hsa034101.93707908
13Protein export_Homo sapiens_hsa030601.81249293
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.81114233
15Oxidative phosphorylation_Homo sapiens_hsa001901.80691229
16RNA degradation_Homo sapiens_hsa030181.79049972
17Mismatch repair_Homo sapiens_hsa034301.77989365
18Basal transcription factors_Homo sapiens_hsa030221.77662262
19Homologous recombination_Homo sapiens_hsa034401.75146487
20RNA polymerase_Homo sapiens_hsa030201.74484639
21Linoleic acid metabolism_Homo sapiens_hsa005911.73501438
22Olfactory transduction_Homo sapiens_hsa047401.71047984
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.71005564
24Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.68087150
25Phototransduction_Homo sapiens_hsa047441.61577371
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.61025385
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.55977011
28Parkinsons disease_Homo sapiens_hsa050121.50582481
29Peroxisome_Homo sapiens_hsa041461.45864919
30Steroid biosynthesis_Homo sapiens_hsa001001.45118410
31Nicotine addiction_Homo sapiens_hsa050331.41225808
32Ether lipid metabolism_Homo sapiens_hsa005651.37408719
33Huntingtons disease_Homo sapiens_hsa050161.32783438
34Fatty acid metabolism_Homo sapiens_hsa012121.28504286
35Glutathione metabolism_Homo sapiens_hsa004801.24606999
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.23054335
37Fatty acid elongation_Homo sapiens_hsa000621.20949173
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.20613141
39Cyanoamino acid metabolism_Homo sapiens_hsa004601.19538076
40Glycosaminoglycan degradation_Homo sapiens_hsa005311.18941902
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.16561245
42Taste transduction_Homo sapiens_hsa047421.12591473
43Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.12283325
44Fatty acid biosynthesis_Homo sapiens_hsa000611.11088041
45Primary bile acid biosynthesis_Homo sapiens_hsa001201.10927179
46One carbon pool by folate_Homo sapiens_hsa006701.09273254
47Spliceosome_Homo sapiens_hsa030401.07985600
48Purine metabolism_Homo sapiens_hsa002301.05690454
49Pyrimidine metabolism_Homo sapiens_hsa002401.05189002
50Tryptophan metabolism_Homo sapiens_hsa003801.04014616
51Arachidonic acid metabolism_Homo sapiens_hsa005901.02715521
52Fatty acid degradation_Homo sapiens_hsa000710.99219554
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.91953774
54Fat digestion and absorption_Homo sapiens_hsa049750.91705135
55N-Glycan biosynthesis_Homo sapiens_hsa005100.91436178
56Metabolic pathways_Homo sapiens_hsa011000.91084986
57Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.89644534
58Maturity onset diabetes of the young_Homo sapiens_hsa049500.85007912
59ABC transporters_Homo sapiens_hsa020100.80814078
60mRNA surveillance pathway_Homo sapiens_hsa030150.78935993
61Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.76663298
62beta-Alanine metabolism_Homo sapiens_hsa004100.74973316
63Salivary secretion_Homo sapiens_hsa049700.73758434
64Alzheimers disease_Homo sapiens_hsa050100.73753022
65Nitrogen metabolism_Homo sapiens_hsa009100.73207794
66Pyruvate metabolism_Homo sapiens_hsa006200.71461594
67Oocyte meiosis_Homo sapiens_hsa041140.70803062
68Glycerophospholipid metabolism_Homo sapiens_hsa005640.70480875
69Serotonergic synapse_Homo sapiens_hsa047260.70049957
70Retinol metabolism_Homo sapiens_hsa008300.69900034
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.68091873
72Dorso-ventral axis formation_Homo sapiens_hsa043200.67364287
73Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.64483872
74Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62701710
75Arginine and proline metabolism_Homo sapiens_hsa003300.60982551
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59155006
77Cardiac muscle contraction_Homo sapiens_hsa042600.57884642
78Nucleotide excision repair_Homo sapiens_hsa034200.57138558
79Folate biosynthesis_Homo sapiens_hsa007900.56548296
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54952384
81Calcium signaling pathway_Homo sapiens_hsa040200.53792342
82p53 signaling pathway_Homo sapiens_hsa041150.50989193
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47513782
84Morphine addiction_Homo sapiens_hsa050320.47346674
85Collecting duct acid secretion_Homo sapiens_hsa049660.46673912
86Regulation of autophagy_Homo sapiens_hsa041400.46120696
87GABAergic synapse_Homo sapiens_hsa047270.45648675
88Ribosome_Homo sapiens_hsa030100.45552419
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45530874
90Glycerolipid metabolism_Homo sapiens_hsa005610.44773886
91Vitamin digestion and absorption_Homo sapiens_hsa049770.44457407
92Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.42852601
93Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.40226111
94Hedgehog signaling pathway_Homo sapiens_hsa043400.39000000
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38144683
96Cell cycle_Homo sapiens_hsa041100.37581323
97Biosynthesis of amino acids_Homo sapiens_hsa012300.37367817
98Synaptic vesicle cycle_Homo sapiens_hsa047210.34551425
99Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.32859078
100Carbon metabolism_Homo sapiens_hsa012000.31142337

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