NPHP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein involved in renal tubular development and function. This protein interacts with nephrocystin, and belongs to a multifunctional complex that is localized to actin- and microtubule-based structures. Mutations in this gene are associated with nephronophthisis type 4, a renal disease, and with Senior-Loken syndrome type 4, a combination of nephronophthisis and retinitis pigmentosa. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.51076040
2positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.32111595
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.25836448
4regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.74439205
5synaptic vesicle maturation (GO:0016188)4.70714720
6vocalization behavior (GO:0071625)4.57245512
7synaptic vesicle docking involved in exocytosis (GO:0016081)4.42773062
8synaptic vesicle exocytosis (GO:0016079)4.31942068
9glutamate secretion (GO:0014047)4.28910322
10locomotory exploration behavior (GO:0035641)4.26490382
11cell-cell junction maintenance (GO:0045217)4.17791917
12axonemal dynein complex assembly (GO:0070286)4.12260612
13regulation of synaptic vesicle exocytosis (GO:2000300)4.11281187
14protein localization to synapse (GO:0035418)4.09564099
15ionotropic glutamate receptor signaling pathway (GO:0035235)4.09072915
16regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.07151690
17histone H3-K9 demethylation (GO:0033169)3.99418782
18positive regulation of synapse maturation (GO:0090129)3.96727075
19regulation of glutamate receptor signaling pathway (GO:1900449)3.91196549
20synaptic transmission, glutamatergic (GO:0035249)3.90719670
21lung epithelium development (GO:0060428)3.84309513
22camera-type eye morphogenesis (GO:0048593)3.82358426
23motile cilium assembly (GO:0044458)3.81230137
24planar cell polarity pathway involved in neural tube closure (GO:0090179)3.79622115
25glutamate receptor signaling pathway (GO:0007215)3.77784674
26fat-soluble vitamin catabolic process (GO:0042363)3.75181099
27vitamin catabolic process (GO:0009111)3.75181099
28regulation of neuronal synaptic plasticity (GO:0048168)3.71776579
29neurotransmitter secretion (GO:0007269)3.69705665
30neuron cell-cell adhesion (GO:0007158)3.62950218
31dendritic spine morphogenesis (GO:0060997)3.60971927
32regulation of synaptic vesicle transport (GO:1902803)3.58333485
33regulation of long-term neuronal synaptic plasticity (GO:0048169)3.55515104
34neuron-neuron synaptic transmission (GO:0007270)3.54112147
35positive regulation of membrane potential (GO:0045838)3.50545977
36regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.48945084
37cellular potassium ion homeostasis (GO:0030007)3.45151004
38intracellular estrogen receptor signaling pathway (GO:0030520)3.43997548
39protein-DNA complex disassembly (GO:0032986)3.43252307
40nucleosome disassembly (GO:0006337)3.43252307
41layer formation in cerebral cortex (GO:0021819)3.42945727
42positive regulation of dendritic spine morphogenesis (GO:0061003)3.40072464
43regulation of excitatory postsynaptic membrane potential (GO:0060079)3.38073737
44response to pheromone (GO:0019236)3.38030612
45apoptotic process involved in morphogenesis (GO:0060561)3.35166477
46regulation of synapse structural plasticity (GO:0051823)3.34120681
47membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.33986253
48cerebellar Purkinje cell differentiation (GO:0021702)3.30649724
49membrane hyperpolarization (GO:0060081)3.30153730
50regulation of postsynaptic membrane potential (GO:0060078)3.29169226
51negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.28772508
52histone H3-K4 methylation (GO:0051568)3.27144751
53positive regulation of gene expression, epigenetic (GO:0045815)3.27012935
54exploration behavior (GO:0035640)3.26661074
55neuron recognition (GO:0008038)3.25334059
56innervation (GO:0060384)3.24929908
57axonal fasciculation (GO:0007413)3.24597384
58membrane depolarization during action potential (GO:0086010)3.23024544
59dendritic spine organization (GO:0097061)3.22057669
60regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.21475465
61neural tube development (GO:0021915)3.20349548
62calcium ion-dependent exocytosis (GO:0017156)3.19699102
63positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.18151850
64neuronal action potential propagation (GO:0019227)3.16347289
65histone H3-K4 trimethylation (GO:0080182)3.15838368
66G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.15794317
67long-term memory (GO:0007616)3.11527859
68DNA synthesis involved in DNA repair (GO:0000731)3.10815339
69histone H3-K36 demethylation (GO:0070544)3.08882396
70establishment of spindle orientation (GO:0051294)3.08183665
71protein insertion into membrane (GO:0051205)3.07704444
72transmission of nerve impulse (GO:0019226)3.06560867
73snRNA metabolic process (GO:0016073)3.06446246
74regulation of dendritic spine morphogenesis (GO:0061001)3.06352252
75sodium ion export (GO:0071436)3.05684265
76establishment of mitotic spindle localization (GO:0040001)3.05620509
77histone lysine demethylation (GO:0070076)3.05592149
78G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.05499138
79establishment of spindle localization (GO:0051293)3.04310739
80regulation of synaptic plasticity (GO:0048167)3.04141594
81endothelial cell chemotaxis (GO:0035767)3.03756045
82establishment of nucleus localization (GO:0040023)3.02908309
83cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.02673333
84neuromuscular process controlling balance (GO:0050885)3.02625871
85establishment of mitotic spindle orientation (GO:0000132)3.02121623
86cell communication by electrical coupling (GO:0010644)2.99916851
87epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.99086857
88negative regulation of histone methylation (GO:0031061)2.98433920
89mitotic chromosome condensation (GO:0007076)2.98316751
90spinal cord development (GO:0021510)2.98199375
91behavioral fear response (GO:0001662)2.98006284
92behavioral defense response (GO:0002209)2.98006284
93regulation of vesicle fusion (GO:0031338)2.97469748
94DNA replication initiation (GO:0006270)2.93655131
95negative regulation of organelle assembly (GO:1902116)2.93579183
96semaphorin-plexin signaling pathway (GO:0071526)2.93417012
97cell junction maintenance (GO:0034331)2.93189332
98regulation of cholesterol biosynthetic process (GO:0045540)2.91863160
99neurotransmitter transport (GO:0006836)2.91730121
100cytoskeletal anchoring at plasma membrane (GO:0007016)2.91578537
101histone demethylation (GO:0016577)2.91246011
102histone H4 deacetylation (GO:0070933)2.90927190
103synaptic vesicle endocytosis (GO:0048488)2.89672875
104negative regulation of cell size (GO:0045792)2.88262877
105regulation of synaptic transmission, glutamatergic (GO:0051966)2.87723812
106regulation of chromatin binding (GO:0035561)2.87275687
107membrane depolarization (GO:0051899)2.85785228
108glucocorticoid receptor signaling pathway (GO:0042921)2.84511021
109neurotransmitter-gated ion channel clustering (GO:0072578)2.83793831
110cell migration in hindbrain (GO:0021535)2.83730535
111cerebral cortex neuron differentiation (GO:0021895)2.83688778
112positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.81423112
113negative regulation of erythrocyte differentiation (GO:0045647)2.80547260
114regulation of ARF GTPase activity (GO:0032312)2.80531544
115regulation of synapse maturation (GO:0090128)2.80323497
116long-term synaptic potentiation (GO:0060291)2.80074845
117mating behavior (GO:0007617)2.79382823
118fat-soluble vitamin biosynthetic process (GO:0042362)2.79344720
119snRNA processing (GO:0016180)2.79247526
120gamma-aminobutyric acid signaling pathway (GO:0007214)2.78825239
121lens morphogenesis in camera-type eye (GO:0002089)2.77359087
122vesicle transport along microtubule (GO:0047496)2.76963268
123pre-miRNA processing (GO:0031054)2.75875641
124apoptotic process involved in development (GO:1902742)2.75600780
125activation of protein kinase A activity (GO:0034199)2.75480495
126chemosensory behavior (GO:0007635)2.75412457
127regulation of NFAT protein import into nucleus (GO:0051532)2.74417437
128fear response (GO:0042596)2.74200127
129regulation of monocyte differentiation (GO:0045655)2.73520545
130regulation of RNA export from nucleus (GO:0046831)2.72790949
131regulation of neurotransmitter secretion (GO:0046928)2.72182770
132establishment or maintenance of monopolar cell polarity (GO:0061339)2.71938019
133establishment of monopolar cell polarity (GO:0061162)2.71938019
134cilium movement (GO:0003341)2.70698427
135DNA unwinding involved in DNA replication (GO:0006268)2.70173800
136neuronal ion channel clustering (GO:0045161)2.68987952
137positive regulation of dendritic spine development (GO:0060999)2.68192267
138stress granule assembly (GO:0034063)2.67469050
139synaptonemal complex assembly (GO:0007130)2.65934279
140histone lysine methylation (GO:0034968)2.65862666
141cilium or flagellum-dependent cell motility (GO:0001539)2.65749226
142dendrite morphogenesis (GO:0048813)2.65500499
143striatum development (GO:0021756)2.65373057
144auditory behavior (GO:0031223)2.64756439
145insulin-like growth factor receptor signaling pathway (GO:0048009)2.63920672
146positive regulation of synaptic transmission, GABAergic (GO:0032230)2.63564432
147regulation of calcium ion-dependent exocytosis (GO:0017158)2.63436149
148positive regulation of vesicle fusion (GO:0031340)2.63353059
149renal system development (GO:0072001)2.62671751
150gamma-aminobutyric acid transport (GO:0015812)2.62623725
151suckling behavior (GO:0001967)2.62222339
152establishment of apical/basal cell polarity (GO:0035089)2.61249078
153neuromuscular process controlling posture (GO:0050884)2.61138401
154protein demethylation (GO:0006482)2.59939363
155protein dealkylation (GO:0008214)2.59939363
156learning (GO:0007612)2.59644157
157mannose metabolic process (GO:0006013)2.59597932
158regulation of neurotransmitter levels (GO:0001505)2.59411689
159growth hormone secretion (GO:0030252)2.59045316
160body morphogenesis (GO:0010171)2.58423609
161activation of Rac GTPase activity (GO:0032863)2.57584123
162chromatin silencing (GO:0006342)2.57409710
163protein retention in ER lumen (GO:0006621)2.57067237
164microtubule severing (GO:0051013)2.56288703
165regulation of nucleobase-containing compound transport (GO:0032239)2.56083612
166regulation of histone H3-K4 methylation (GO:0051569)2.55651843
167positive regulation of neurotransmitter transport (GO:0051590)2.55645799
168positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.55198115
169regulation of neurotransmitter transport (GO:0051588)2.54950428
170left/right pattern formation (GO:0060972)2.54875741
171chromosome condensation (GO:0030261)2.53422371
172positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.53339983
173regulation of cilium assembly (GO:1902017)2.53150160
174microtubule depolymerization (GO:0007019)2.52381668
175negative regulation of gene expression, epigenetic (GO:0045814)2.51195328
176cellular protein complex localization (GO:0034629)2.51056417
177regulation of ARF protein signal transduction (GO:0032012)2.50199911
178activation of MAPKKK activity (GO:0000185)2.49099721
179ventricular system development (GO:0021591)2.47078053
180embryonic camera-type eye development (GO:0031076)2.47016806
181histone H3 deacetylation (GO:0070932)2.46778663
182DNA methylation (GO:0006306)2.46218213
183DNA alkylation (GO:0006305)2.46218213
184eye morphogenesis (GO:0048592)2.45469087
185positive regulation of DNA-dependent DNA replication (GO:2000105)2.44472914
186axon extension involved in axon guidance (GO:0048846)2.40400116
187neuron projection extension involved in neuron projection guidance (GO:1902284)2.40400116
188intraciliary transport (GO:0042073)2.40318111
189regulation of histone H3-K27 methylation (GO:0061085)2.39751444

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.80972913
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.89137899
3GBX2_23144817_ChIP-Seq_PC3_Human3.24491504
4RARB_27405468_Chip-Seq_BRAIN_Mouse3.10362087
5LXR_22292898_ChIP-Seq_THP-1_Human3.06451128
6REST_21632747_ChIP-Seq_MESCs_Mouse2.77638083
7KDM2B_26808549_Chip-Seq_SUP-B15_Human2.68524293
8DROSHA_22980978_ChIP-Seq_HELA_Human2.66051096
9VDR_21846776_ChIP-Seq_THP-1_Human2.63503903
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.54551202
11E2F7_22180533_ChIP-Seq_HELA_Human2.53931569
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.53299590
13EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.47675593
14* MYC_22102868_ChIP-Seq_BL_Human2.47256292
15CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.46237196
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.45414186
17SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.43949626
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.42615204
19* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.40394647
20REST_18959480_ChIP-ChIP_MESCs_Mouse2.34306888
21EZH2_18974828_ChIP-Seq_MESCs_Mouse2.30058188
22RNF2_18974828_ChIP-Seq_MESCs_Mouse2.30058188
23EZH2_27304074_Chip-Seq_ESCs_Mouse2.24573470
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.21583873
25SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.21366976
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.21192078
27* KDM2B_26808549_Chip-Seq_DND41_Human2.17375194
28MTF2_20144788_ChIP-Seq_MESCs_Mouse2.14454962
29IKZF1_21737484_ChIP-ChIP_HCT116_Human2.12668123
30EZH2_27294783_Chip-Seq_ESCs_Mouse2.07818812
31SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.07643215
32* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.07575703
33SUZ12_27294783_Chip-Seq_ESCs_Mouse2.07034845
34TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.04840629
35P68_20966046_ChIP-Seq_HELA_Human2.04389766
36* ELK3_25401928_ChIP-Seq_HUVEC_Human2.04226781
37TP63_17297297_ChIP-ChIP_HaCaT_Human2.03936284
38SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.96434284
39NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.95426008
40TCF7_22412390_ChIP-Seq_EML_Mouse1.93323994
41* KDM2B_26808549_Chip-Seq_JURKAT_Human1.92481574
42EED_16625203_ChIP-ChIP_MESCs_Mouse1.91298340
43RACK7_27058665_Chip-Seq_MCF-7_Human1.90497552
44PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.90317737
45* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.89365497
46FOXM1_23109430_ChIP-Seq_U2OS_Human1.82731133
47ZNF274_21170338_ChIP-Seq_K562_Hela1.75760529
48MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.73730130
49GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.73141073
50* SA1_27219007_Chip-Seq_ERYTHROID_Human1.69173903
51SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.69144890
52* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.66206361
53* CREB1_26743006_Chip-Seq_LNCaP_Human1.62792337
54* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.60056129
55* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.53547216
56SMAD4_21799915_ChIP-Seq_A2780_Human1.50988164
57ZFP281_18757296_ChIP-ChIP_E14_Mouse1.50783688
58CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.47499226
59TET1_21451524_ChIP-Seq_MESCs_Mouse1.47202230
60ERG_21242973_ChIP-ChIP_JURKAT_Human1.45942628
61* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.45785797
62* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41935642
63RING1B_27294783_Chip-Seq_ESCs_Mouse1.41821908
64DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.38530936
65* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.38343554
66RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.38326494
67RUNX1_27514584_Chip-Seq_MCF-7_Human1.37376836
68RING1B_27294783_Chip-Seq_NPCs_Mouse1.37250165
69EGR1_19374776_ChIP-ChIP_THP-1_Human1.36937719
70AR_19668381_ChIP-Seq_PC3_Human1.36070853
71* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.34150728
72* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.34119836
73* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.33706588
74ESR2_21235772_ChIP-Seq_MCF-7_Human1.33461620
75PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29147905
76RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.28844170
77TP53_22127205_ChIP-Seq_IMR90_Human1.28802307
78EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.27766320
79* SOX2_21211035_ChIP-Seq_LN229_Gbm1.27731992
80HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.27416987
81BCOR_27268052_Chip-Seq_Bcells_Human1.27148188
82* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.26885331
83* KDM2B_26808549_Chip-Seq_K562_Human1.26668507
84TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.25098287
85ZFP281_27345836_Chip-Seq_ESCs_Mouse1.25055494
86WT1_25993318_ChIP-Seq_PODOCYTE_Human1.24322137
87PHF8_20622854_ChIP-Seq_HELA_Human1.23655076
88* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.23195609
89ELF1_20517297_ChIP-Seq_JURKAT_Human1.23159847
90SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.22921204
91* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.22565752
92* TP63_22573176_ChIP-Seq_HFKS_Human1.21763287
93WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.21729075
94TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.21603129
95SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21314616
96* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.20572476
97SRY_22984422_ChIP-ChIP_TESTIS_Rat1.20308471
98STAT3_23295773_ChIP-Seq_U87_Human1.19180852
99SMAD3_21741376_ChIP-Seq_EPCs_Human1.18949395
100* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18846081
101GATA1_26923725_Chip-Seq_HPCs_Mouse1.17862149
102NCOR1_26117541_ChIP-Seq_K562_Human1.17615783
103KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.15921088
104SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.15795495
105ESR1_15608294_ChIP-ChIP_MCF-7_Human1.15522927
106OCT4_19829295_ChIP-Seq_ESCs_Human1.14540107
107CBX2_27304074_Chip-Seq_ESCs_Mouse1.13897709
108ZNF263_19887448_ChIP-Seq_K562_Human1.13127243
109NR3C1_23031785_ChIP-Seq_PC12_Mouse1.12975595
110ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.12097402
111TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.12069544
112NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.11860065
113YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11681060
114BCL6_27268052_Chip-Seq_Bcells_Human1.11275922
115SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11118584
116AR_21572438_ChIP-Seq_LNCaP_Human1.10843790
117RNF2_27304074_Chip-Seq_NSC_Mouse1.10719788
118SMAD3_21741376_ChIP-Seq_ESCs_Human1.10411622
119OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.10405575
120TCF4_23295773_ChIP-Seq_U87_Human1.08585051
121RARG_19884340_ChIP-ChIP_MEFs_Mouse1.08141081
122* MAF_26560356_Chip-Seq_TH2_Human1.06994910
123* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.06340115
124NFIB_24661679_ChIP-Seq_LUNG_Mouse1.05451199
125CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.05074332
126NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.04525312
127* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02930859
128TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02407749
129P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02228308
130IGF1R_20145208_ChIP-Seq_DFB_Human1.01994130
131TET1_21490601_ChIP-Seq_MESCs_Mouse1.01842022
132KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01711656
133MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01562757
134* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.01261064
135TP53_20018659_ChIP-ChIP_R1E_Mouse1.00666883
136POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00440295
137TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00440295
138SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.00301408
139* CTCF_27219007_Chip-Seq_Bcells_Human0.99565186
140E2F1_20622854_ChIP-Seq_HELA_Human0.99165549
141TP53_23651856_ChIP-Seq_MEFs_Mouse0.98955826
142* AR_25329375_ChIP-Seq_VCAP_Human0.98202971
143* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.98098687
144STAT6_21828071_ChIP-Seq_BEAS2B_Human0.97508267
145PKCTHETA_26484144_Chip-Seq_BREAST_Human0.97472400
146VDR_24763502_ChIP-Seq_THP-1_Human0.97266616
147DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96964622
148WDR5_24793694_ChIP-Seq_LNCAP_Human0.96886358
149GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96467676
150P300_19829295_ChIP-Seq_ESCs_Human0.96145099
151ZNF217_24962896_ChIP-Seq_MCF-7_Human0.93579569
152TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93135360
153BMI1_23680149_ChIP-Seq_NPCS_Mouse0.93093619
154NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92133191
155ARNT_22903824_ChIP-Seq_MCF-7_Human0.91492819
156BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.90747416
157FUS_26573619_Chip-Seq_HEK293_Human0.87276837
158CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.86690813
159VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.86652982
160SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.86414067
161* SOX9_26525672_Chip-Seq_HEART_Mouse0.85525143
162SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.85336585
163CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.84548381
164SMC4_20622854_ChIP-Seq_HELA_Human0.83912498

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.78151880
2MP0000566_synostosis5.19352236
3MP0003880_abnormal_central_pattern3.57726898
4MP0003635_abnormal_synaptic_transmissio3.56770766
5MP0005076_abnormal_cell_differentiation3.17294606
6MP0002063_abnormal_learning/memory/cond2.94492376
7MP0004270_analgesia2.91620545
8MP0003705_abnormal_hypodermis_morpholog2.81048841
9MP0009745_abnormal_behavioral_response2.79083434
10MP0010030_abnormal_orbit_morphology2.74651715
11MP0002822_catalepsy2.68293250
12MP0005409_darkened_coat_color2.66151263
13MP0002249_abnormal_larynx_morphology2.57361890
14MP0002064_seizures2.45639826
15MP0002572_abnormal_emotion/affect_behav2.41767228
16MP0008877_abnormal_DNA_methylation2.41731949
17MP0003878_abnormal_ear_physiology2.38717532
18MP0005377_hearing/vestibular/ear_phenot2.38717532
19MP0002653_abnormal_ependyma_morphology2.32596591
20MP0009046_muscle_twitch2.25694639
21MP0005423_abnormal_somatic_nervous2.22995196
22MP0001968_abnormal_touch/_nociception2.17080513
23MP0002272_abnormal_nervous_system2.14402424
24MP0003122_maternal_imprinting2.03186560
25MP0002735_abnormal_chemical_nociception2.01632226
26MP0003283_abnormal_digestive_organ1.98454569
27MP0001486_abnormal_startle_reflex1.90971116
28MP0001501_abnormal_sleep_pattern1.90784306
29MP0002734_abnormal_mechanical_nocicepti1.86097368
30MP0002184_abnormal_innervation1.83812601
31MP0000778_abnormal_nervous_system1.81271394
32MP0005257_abnormal_intraocular_pressure1.75739908
33MP0003787_abnormal_imprinting1.73592385
34MP0002736_abnormal_nociception_after1.71472566
35MP0000678_abnormal_parathyroid_gland1.71176583
36MP0005551_abnormal_eye_electrophysiolog1.70722041
37MP0002089_abnormal_postnatal_growth/wei1.69236352
38MP0002909_abnormal_adrenal_gland1.67847414
39MP0001348_abnormal_lacrimal_gland1.66527729
40MP0009278_abnormal_bone_marrow1.66308403
41MP0001984_abnormal_olfaction1.64350132
42MP0002557_abnormal_social/conspecific_i1.61715130
43MP0004811_abnormal_neuron_physiology1.61337135
44MP0004885_abnormal_endolymph1.59356091
45MP0003115_abnormal_respiratory_system1.58649125
46MP0002234_abnormal_pharynx_morphology1.57889100
47MP0000015_abnormal_ear_pigmentation1.56876229
48MP0003879_abnormal_hair_cell1.56717561
49MP0000955_abnormal_spinal_cord1.55983926
50MP0006072_abnormal_retinal_apoptosis1.55290329
51MP0001440_abnormal_grooming_behavior1.51784588
52MP0002067_abnormal_sensory_capabilities1.50835726
53MP0004858_abnormal_nervous_system1.49124509
54MP0002733_abnormal_thermal_nociception1.46954064
55MP0002882_abnormal_neuron_morphology1.46043465
56MP0002697_abnormal_eye_size1.42005155
57MP0001529_abnormal_vocalization1.41882228
58MP0001970_abnormal_pain_threshold1.41329195
59MP0005394_taste/olfaction_phenotype1.41217284
60MP0005499_abnormal_olfactory_system1.41217284
61MP0003123_paternal_imprinting1.39577736
62MP0005623_abnormal_meninges_morphology1.39528127
63MP0005410_abnormal_fertilization1.39397999
64MP0008569_lethality_at_weaning1.37233259
65MP0008260_abnormal_autophagy1.35856053
66MP0004233_abnormal_muscle_weight1.35252976
67MP0002092_abnormal_eye_morphology1.34745129
68MP0003938_abnormal_ear_development1.34620329
69MP0001502_abnormal_circadian_rhythm1.33997521
70MP0005645_abnormal_hypothalamus_physiol1.33618013
71MP0009780_abnormal_chondrocyte_physiolo1.32706770
72MP0003121_genomic_imprinting1.30017902
73MP0001346_abnormal_lacrimal_gland1.29714099
74MP0003172_abnormal_lysosome_physiology1.28572120
75MP0001849_ear_inflammation1.28307201
76MP0004924_abnormal_behavior1.27800326
77MP0005386_behavior/neurological_phenoty1.27800326
78MP0005646_abnormal_pituitary_gland1.27662410
79MP0002152_abnormal_brain_morphology1.27486066
80MP0005058_abnormal_lysosome_morphology1.25461652
81MP0002116_abnormal_craniofacial_bone1.22842579
82MP0006292_abnormal_olfactory_placode1.22053842
83MP0000579_abnormal_nail_morphology1.20740429
84MP0001730_embryonic_growth_arrest1.20203961
85MP0002066_abnormal_motor_capabilities/c1.18826815
86MP0000003_abnormal_adipose_tissue1.17725643
87MP0008961_abnormal_basal_metabolism1.15974772
88MP0003111_abnormal_nucleus_morphology1.15682513
89MP0005253_abnormal_eye_physiology1.14021704
90MP0003861_abnormal_nervous_system1.11388690
91MP0000631_abnormal_neuroendocrine_gland1.09869196
92MP0000569_abnormal_digit_pigmentation1.09313816
93MP0009053_abnormal_anal_canal1.07722701
94MP0003698_abnormal_male_reproductive1.06462913
95MP0004145_abnormal_muscle_electrophysio1.04615673
96MP0000026_abnormal_inner_ear1.04156110
97MP0005670_abnormal_white_adipose1.03491964
98MP0005248_abnormal_Harderian_gland1.03412322
99MP0003136_yellow_coat_color1.00417943
100MP0002075_abnormal_coat/hair_pigmentati0.97728542
101MP0004742_abnormal_vestibular_system0.96672670
102MP0006276_abnormal_autonomic_nervous0.96566815
103MP0002752_abnormal_somatic_nervous0.95853175
104MP0003959_abnormal_lean_body0.95646897
105MP0000383_abnormal_hair_follicle0.95442511
106MP0004133_heterotaxia0.95327234
107MP0000013_abnormal_adipose_tissue0.95279191
108MP0000534_abnormal_ureter_morphology0.95220206
109MP0003329_amyloid_beta_deposits0.95036057
110MP0003119_abnormal_digestive_system0.93688632
111MP0004185_abnormal_adipocyte_glucose0.91647903
112MP0002638_abnormal_pupillary_reflex0.90709332
113MP0005666_abnormal_adipose_tissue0.90118063
114MP0002229_neurodegeneration0.89633749
115MP0008789_abnormal_olfactory_epithelium0.89050524
116MP0009672_abnormal_birth_weight0.88505287
117MP0005375_adipose_tissue_phenotype0.87285838
118MP0000733_abnormal_muscle_development0.86923003
119MP0002085_abnormal_embryonic_tissue0.86337324
120MP0010307_abnormal_tumor_latency0.85926261
121MP0003453_abnormal_keratinocyte_physiol0.85867976
122MP0001485_abnormal_pinna_reflex0.85189828
123MP0000049_abnormal_middle_ear0.84083691
124MP0004808_abnormal_hematopoietic_stem0.83798184
125MP0003943_abnormal_hepatobiliary_system0.83109849
126MP0002084_abnormal_developmental_patter0.81448572
127MP0002970_abnormal_white_adipose0.81357324
128MP0003385_abnormal_body_wall0.80613211
129MP0001286_abnormal_eye_development0.80032847
130MP0002081_perinatal_lethality0.79636834
131MP0001929_abnormal_gametogenesis0.79616560
132MP0000428_abnormal_craniofacial_morphol0.79023845
133MP0000751_myopathy0.76951951
134MP0002069_abnormal_eating/drinking_beha0.75885416
135MP0005195_abnormal_posterior_eye0.74648811
136MP0002233_abnormal_nose_morphology0.73931637
137MP0004142_abnormal_muscle_tone0.73233639
138MP0003091_abnormal_cell_migration0.73026100
139MP0003935_abnormal_craniofacial_develop0.72806181
140MP0010094_abnormal_chromosome_stability0.72685430
141MP0004197_abnormal_fetal_growth/weight/0.72132229
142MP0003077_abnormal_cell_cycle0.72064695
143MP0003633_abnormal_nervous_system0.71632362
144MP0001963_abnormal_hearing_physiology0.71465281
145MP0001905_abnormal_dopamine_level0.71106183
146MP0003937_abnormal_limbs/digits/tail_de0.69945115
147MP0002932_abnormal_joint_morphology0.69226712
148MP0001944_abnormal_pancreas_morphology0.68528228
149MP0003634_abnormal_glial_cell0.68084907
150MP0003631_nervous_system_phenotype0.67775896
151MP0003890_abnormal_embryonic-extraembry0.66670438
152MP0001188_hyperpigmentation0.66203326
153MP0002161_abnormal_fertility/fecundity0.66188035
154MP0004085_abnormal_heartbeat0.66054158
155MP0010386_abnormal_urinary_bladder0.65526139
156MP0002751_abnormal_autonomic_nervous0.64986588
157MP0002090_abnormal_vision0.64348676
158MP0001299_abnormal_eye_distance/0.61923359
159MP0002210_abnormal_sex_determination0.61824099
160MP0001177_atelectasis0.61603891
161MP0003942_abnormal_urinary_system0.60875767

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.14437686
2Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.70522481
3Myokymia (HP:0002411)4.14674451
4Focal seizures (HP:0007359)4.01429359
5Visual hallucinations (HP:0002367)3.81984748
6Epileptic encephalopathy (HP:0200134)3.62440677
7Obstructive sleep apnea (HP:0002870)3.58880593
8Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.54587063
9Abnormal respiratory motile cilium physiology (HP:0012261)3.25110380
10Abnormality of the lower motor neuron (HP:0002366)3.25087677
11Renovascular hypertension (HP:0100817)3.21282148
12Atonic seizures (HP:0010819)3.06733796
13Broad face (HP:0000283)3.05141136
14Absent/shortened dynein arms (HP:0200106)3.03989621
15Dynein arm defect of respiratory motile cilia (HP:0012255)3.03989621
16Abnormality of the fingertips (HP:0001211)2.95049023
17Abnormal ciliary motility (HP:0012262)2.92509925
18Progressive cerebellar ataxia (HP:0002073)2.77204588
19Rhinitis (HP:0012384)2.70036203
20Febrile seizures (HP:0002373)2.67430291
21Atelectasis (HP:0100750)2.65093201
22Abnormal respiratory motile cilium morphology (HP:0005938)2.62172012
23Abnormal respiratory epithelium morphology (HP:0012253)2.62172012
24Thin bony cortex (HP:0002753)2.61506392
25Absence seizures (HP:0002121)2.58071165
26Dialeptic seizures (HP:0011146)2.57775516
27Impaired smooth pursuit (HP:0007772)2.57362722
28Elfin facies (HP:0004428)2.53730317
29Overriding aorta (HP:0002623)2.52609719
30Impaired vibration sensation in the lower limbs (HP:0002166)2.49239304
31Increased nuchal translucency (HP:0010880)2.46477117
32Ankle clonus (HP:0011448)2.46463478
33Alacrima (HP:0000522)2.45333539
34Gaze-evoked nystagmus (HP:0000640)2.44795769
35Tubulointerstitial nephritis (HP:0001970)2.43940919
36Generalized tonic-clonic seizures (HP:0002069)2.43344041
37Abnormality of calcium-phosphate metabolism (HP:0100530)2.41808542
38Abnormality of the aortic arch (HP:0012303)2.41123144
39Precocious puberty (HP:0000826)2.41049548
40Genetic anticipation (HP:0003743)2.38468776
41Dysdiadochokinesis (HP:0002075)2.32169678
42Abnormality of ocular smooth pursuit (HP:0000617)2.31846618
43Bony spicule pigmentary retinopathy (HP:0007737)2.29051396
44Absent epiphyses (HP:0010577)2.28970362
45Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.28970362
46Urinary bladder sphincter dysfunction (HP:0002839)2.26591528
47Epileptiform EEG discharges (HP:0011182)2.25862324
48Supranuclear gaze palsy (HP:0000605)2.24135551
49Poor eye contact (HP:0000817)2.23807937
50Pointed chin (HP:0000307)2.22511187
51Truncal ataxia (HP:0002078)2.20907925
52Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.20842478
53Chronic bronchitis (HP:0004469)2.20019798
54Disproportionate tall stature (HP:0001519)2.18832707
55Urethral obstruction (HP:0000796)2.18727167
56Shallow orbits (HP:0000586)2.18667356
57* Amblyopia (HP:0000646)2.15534819
58Long palpebral fissure (HP:0000637)2.15122215
59Flat cornea (HP:0007720)2.14469008
60Self-mutilation (HP:0000742)2.14313844
61Heterotopia (HP:0002282)2.14248178
62EEG with generalized epileptiform discharges (HP:0011198)2.13591343
63Hemiparesis (HP:0001269)2.12559904
64Abnormality of cochlea (HP:0000375)2.11823148
65Action tremor (HP:0002345)2.10829506
66Central scotoma (HP:0000603)2.10766808
67Natal tooth (HP:0000695)2.10334009
68Truncal obesity (HP:0001956)2.10176565
69Lip pit (HP:0100267)2.08016966
70Decreased circulating renin level (HP:0003351)2.07579623
71Widely patent fontanelles and sutures (HP:0004492)2.06683725
72Insomnia (HP:0100785)2.06174652
73Hypoplasia of the capital femoral epiphysis (HP:0003090)2.06135532
74Depression (HP:0000716)2.06062483
75Patellar dislocation (HP:0002999)2.03804365
76Ulnar bowing (HP:0003031)2.03200366
77Long eyelashes (HP:0000527)2.01121515
78Deep palmar crease (HP:0006191)2.00127932
79Postural instability (HP:0002172)1.99531363
80Broad-based gait (HP:0002136)1.99324226
81Abnormality of abdominal situs (HP:0011620)1.98774435
82Abdominal situs inversus (HP:0003363)1.98774435
83Abnormal number of incisors (HP:0011064)1.97988781
84Facial hemangioma (HP:0000329)1.97662379
85Hypsarrhythmia (HP:0002521)1.95788410
86Urinary urgency (HP:0000012)1.95526392
87Hyperparathyroidism (HP:0000843)1.93813087
88Distal upper limb amyotrophy (HP:0007149)1.92439670
89Upper limb amyotrophy (HP:0009129)1.92439670
90Bronchomalacia (HP:0002780)1.91979621
91Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.91946222
92Impaired social interactions (HP:0000735)1.91788484
93Abnormal social behavior (HP:0012433)1.91788484
94Gait imbalance (HP:0002141)1.90674801
95High anterior hairline (HP:0009890)1.90279535
96Dysmetria (HP:0001310)1.89598499
97Arnold-Chiari malformation (HP:0002308)1.88952037
98Cerebral aneurysm (HP:0004944)1.88523239
99Neoplasm of the heart (HP:0100544)1.88365327
100Abnormality of macular pigmentation (HP:0008002)1.85092384
101Chronic hepatic failure (HP:0100626)1.84154117
102Congenital stationary night blindness (HP:0007642)1.83980950
103* Polycystic kidney dysplasia (HP:0000113)1.83894353
104Oligodactyly (HP:0012165)1.83862925
105Hemiplegia (HP:0002301)1.83484445
106Hyperventilation (HP:0002883)1.83246357
107Excessive salivation (HP:0003781)1.82691571
108Drooling (HP:0002307)1.82691571
109Spina bifida occulta (HP:0003298)1.82293541
110Sleep apnea (HP:0010535)1.81491376
111Choroideremia (HP:0001139)1.81149070
112Shoulder girdle muscle weakness (HP:0003547)1.80817679
113Bell-shaped thorax (HP:0001591)1.80809181
114Trigonocephaly (HP:0000243)1.80316683
115Abnormality of the distal phalanx of the thumb (HP:0009617)1.80313776
116Spastic gait (HP:0002064)1.79058565
117Metaphyseal cupping (HP:0003021)1.78753205
118Optic nerve coloboma (HP:0000588)1.78411617
119Astrocytoma (HP:0009592)1.78329266
120Abnormality of the astrocytes (HP:0100707)1.78329266
121Absent speech (HP:0001344)1.78228112
122Abnormality of the diencephalon (HP:0010662)1.78015000
123Short nail (HP:0001799)1.77256699
124Nasal polyposis (HP:0100582)1.76646416
125Impulsivity (HP:0100710)1.76295328
126Annular pancreas (HP:0001734)1.75879799
127Type II diabetes mellitus (HP:0005978)1.73651618
128Obsessive-compulsive behavior (HP:0000722)1.73156078
129Ependymoma (HP:0002888)1.73068978
130Abnormal rod and cone electroretinograms (HP:0008323)1.73049155
131Broad phalanges of the hand (HP:0009768)1.72814469
132Peripheral hypomyelination (HP:0007182)1.72715471
133Abnormality of the thoracic spine (HP:0100711)1.72412871
134Congenital primary aphakia (HP:0007707)1.71855178
135Turricephaly (HP:0000262)1.71037136
136Anxiety (HP:0000739)1.71006284
137Dysmetric saccades (HP:0000641)1.70664218
138Scotoma (HP:0000575)1.70430356
139Molar tooth sign on MRI (HP:0002419)1.70329531
140Abnormality of midbrain morphology (HP:0002418)1.70329531
141Diplopia (HP:0000651)1.69436560
142Abnormality of binocular vision (HP:0011514)1.69436560
143Megalocornea (HP:0000485)1.69087367
144Hypoventilation (HP:0002791)1.68580228
145Flat acetabular roof (HP:0003180)1.68248395
146Ectopic kidney (HP:0000086)1.68025193
147Megalencephaly (HP:0001355)1.67928635
148Mitral regurgitation (HP:0001653)1.67572956
149Bradykinesia (HP:0002067)1.67372858
150Symptomatic seizures (HP:0011145)1.66858722
151Broad thumb (HP:0011304)1.66407578
152Abnormality of the corticospinal tract (HP:0002492)1.65831669
153Truncus arteriosus (HP:0001660)1.65671873
154Hand muscle atrophy (HP:0009130)1.65190506
155Abnormality of the radial head (HP:0003995)1.63926550
156Specific learning disability (HP:0001328)1.63844517
157Cervical subluxation (HP:0003308)1.63729762
158Occipital encephalocele (HP:0002085)1.63448900
159Decreased lacrimation (HP:0000633)1.62342804
160Papilledema (HP:0001085)1.60319056
161Dislocated radial head (HP:0003083)1.59858120
162Aplasia involving bones of the extremities (HP:0009825)1.59754856
163Aplasia involving bones of the upper limbs (HP:0009823)1.59754856
164Aplasia of the phalanges of the hand (HP:0009802)1.59754856
165Morphological abnormality of the inner ear (HP:0011390)1.59489499
166Medial flaring of the eyebrow (HP:0010747)1.59321241
167Advanced eruption of teeth (HP:0006288)1.59204779
168Anal stenosis (HP:0002025)1.59026327
169Hyperacusis (HP:0010780)1.58856869
170Amyotrophic lateral sclerosis (HP:0007354)1.58658656
171Attention deficit hyperactivity disorder (HP:0007018)1.58480309
172Broad finger (HP:0001500)1.58460076
173Stereotypic behavior (HP:0000733)1.58141831
174Cystic liver disease (HP:0006706)1.57409747
175Delayed epiphyseal ossification (HP:0002663)1.57219916
176Abnormality of the intervertebral disk (HP:0005108)1.56939434
177* Nephronophthisis (HP:0000090)1.56138051
178Broad hallux (HP:0010055)1.55755843
179Lower limb muscle weakness (HP:0007340)1.54766165
180Flat occiput (HP:0005469)1.54584031
181Renal duplication (HP:0000075)1.53684237
182Nephrogenic diabetes insipidus (HP:0009806)1.52555379
183Broad distal phalanx of finger (HP:0009836)1.52487530

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.62114547
2EPHA44.19766484
3PRKD33.40524785
4MAP3K93.35593443
5MAPK153.18303172
6SIK22.95641396
7MARK12.65536541
8MAP3K42.53757743
9MINK12.49643929
10SIK12.43406438
11KSR12.38662069
12PAK62.17525016
13DAPK22.11682253
14PNCK2.06410292
15NTRK22.01595980
16KSR21.95732406
17ICK1.87976690
18RIPK11.87789154
19SMG11.85857069
20IRAK31.69963404
21IRAK21.67207561
22CAMKK11.66765400
23DAPK11.59178229
24MAP3K61.55136868
25MTOR1.51971540
26MAP2K71.51501340
27PRPF4B1.46007115
28UHMK11.34934340
29NTRK11.32335599
30RIPK41.31381074
31CDK51.28166217
32PTK2B1.27120069
33TYRO31.27014742
34STK381.26450687
35TRIB31.20027491
36CAMK1G1.19669499
37MAP3K111.17755877
38CDK181.13017427
39MAPK131.12227179
40MARK21.08548866
41PLK21.08332383
42CDK151.07931907
43BMX1.07669642
44MAP3K21.06164286
45LATS21.02118570
46CDK141.00617057
47PRKCG1.00450715
48SIK30.96770911
49MAP3K70.96371229
50CDK11A0.96193444
51MAP3K130.95548727
52NEK20.95511550
53FGFR40.94355066
54RPS6KA20.94343302
55DYRK1A0.92492260
56MST1R0.91287472
57MAP2K40.89920780
58CDC42BPA0.89710301
59EPHA20.87838063
60CDC70.87529119
61AURKA0.86600579
62WNK40.86167404
63CDK120.85797126
64ALK0.81792883
65MAP2K30.80836212
66PASK0.80821051
67TAOK20.80488820
68NME10.79820468
69WNK10.77347444
70FES0.75527529
71SCYL20.75306433
72CDK80.74973488
73CAMK2A0.74765536
74INSRR0.72909836
75ERN10.72876645
76PRKCH0.72715765
77TAOK10.72018666
78PDPK10.71943401
79PAK30.71462948
80IRAK40.71373607
81GRK50.69853095
82CCNB10.69218145
83MET0.68714765
84CAMK10.68697173
85BRSK10.68563916
86NEK10.68232614
87RPS6KC10.67979454
88RPS6KL10.67979454
89MAP3K100.67801775
90CAMKK20.66804807
91CSNK1G20.65934101
92CDK40.65604377
93PTK60.64464330
94MAPK110.63200168
95SGK10.62912485
96CHEK20.62768010
97CAMK2B0.61319691
98PDGFRA0.61010709
99RET0.60610610
100CDK70.59656645
101SGK2230.59103136
102SGK4940.59103136
103TNK20.58100863
104MAP3K30.58038834
105STK110.57783574
106ARAF0.57115399
107PRKAA10.57110147
108MAPK100.57059342
109RPS6KA60.57021083
110RPS6KA30.55851431
111CSNK1E0.54901928
112CDK10.54149639
113LIMK10.54112788
114BCR0.53989500
115RPS6KB20.53831005
116LMTK20.52957454
117EEF2K0.52272106
118CAMK1D0.52152030
119MAP2K20.50982156
120WNK30.50772660
121FER0.50443956
122RAF10.49863275
123DYRK1B0.49701239
124TESK10.49141875
125RPS6KA10.48984717
126MAPKAPK30.48380968
127CAMK40.48129637
128EPHB10.46782846
129TNIK0.45847630
130BRAF0.44682542
131GSK3B0.44546032
132PDK10.43760610
133FGR0.43622446
134HIPK20.42572215
135YES10.42488368
136MAP3K80.42477251
137PRKCB0.42240929
138PTK20.39697598
139PRKD20.38906730
140AKT10.38821671
141MAPK90.37995687
142PKN20.37825576
143BRD40.37740068
144BMPR20.36990569
145CAMK2D0.36740039
146MAPK80.36590772
147PRKDC0.35878207
148CHEK10.35195810
149CDK20.34584228
150SGK20.34518220
151CSNK1D0.34086110
152DDR20.33242535

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041223.34481412
2Nicotine addiction_Homo sapiens_hsa050333.25354105
3Notch signaling pathway_Homo sapiens_hsa043302.98268952
4Synaptic vesicle cycle_Homo sapiens_hsa047212.96188664
5Circadian entrainment_Homo sapiens_hsa047132.75127550
6Olfactory transduction_Homo sapiens_hsa047402.74799244
7Long-term potentiation_Homo sapiens_hsa047202.65616676
8Amphetamine addiction_Homo sapiens_hsa050312.59165441
9GABAergic synapse_Homo sapiens_hsa047272.53091467
10Glutamatergic synapse_Homo sapiens_hsa047242.48432686
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.43944029
12Insulin secretion_Homo sapiens_hsa049112.36266119
13Morphine addiction_Homo sapiens_hsa050322.32660871
14Dopaminergic synapse_Homo sapiens_hsa047282.25798945
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.17069504
16Lysine degradation_Homo sapiens_hsa003102.08763421
17Phototransduction_Homo sapiens_hsa047441.98109683
18Chronic myeloid leukemia_Homo sapiens_hsa052201.81938435
19Cholinergic synapse_Homo sapiens_hsa047251.81235091
20Salivary secretion_Homo sapiens_hsa049701.77056660
21Cocaine addiction_Homo sapiens_hsa050301.76989239
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.69437742
23Other glycan degradation_Homo sapiens_hsa005111.66535515
24Oxytocin signaling pathway_Homo sapiens_hsa049211.60615870
25Taste transduction_Homo sapiens_hsa047421.59570667
26Long-term depression_Homo sapiens_hsa047301.57693988
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.57583934
28Renin secretion_Homo sapiens_hsa049241.53939611
29Serotonergic synapse_Homo sapiens_hsa047261.49571021
30Gastric acid secretion_Homo sapiens_hsa049711.49246764
31Calcium signaling pathway_Homo sapiens_hsa040201.43285536
32Type II diabetes mellitus_Homo sapiens_hsa049301.42181289
33Oocyte meiosis_Homo sapiens_hsa041141.38871200
34Acute myeloid leukemia_Homo sapiens_hsa052211.36622405
35GnRH signaling pathway_Homo sapiens_hsa049121.32862002
36Gap junction_Homo sapiens_hsa045401.28919837
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.27583347
38Glycosaminoglycan degradation_Homo sapiens_hsa005311.25348624
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.25240873
40cGMP-PKG signaling pathway_Homo sapiens_hsa040221.22675195
41cAMP signaling pathway_Homo sapiens_hsa040241.22670648
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.21591660
43Estrogen signaling pathway_Homo sapiens_hsa049151.21242660
44Bladder cancer_Homo sapiens_hsa052191.19945668
45Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.18433795
46Cell cycle_Homo sapiens_hsa041101.18071026
47Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.17957851
48Axon guidance_Homo sapiens_hsa043601.17496788
49Prion diseases_Homo sapiens_hsa050201.15739459
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15141631
51Melanogenesis_Homo sapiens_hsa049161.11108613
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.10848192
53Glioma_Homo sapiens_hsa052141.08345278
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.07439384
55Vibrio cholerae infection_Homo sapiens_hsa051101.07202774
56Collecting duct acid secretion_Homo sapiens_hsa049661.01401505
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.01009799
58Pancreatic cancer_Homo sapiens_hsa052120.99887597
59Glucagon signaling pathway_Homo sapiens_hsa049220.96377850
60Carbohydrate digestion and absorption_Homo sapiens_hsa049730.94690844
61Base excision repair_Homo sapiens_hsa034100.93699372
62Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.89832971
63Vascular smooth muscle contraction_Homo sapiens_hsa042700.89747234
64Alcoholism_Homo sapiens_hsa050340.89614009
65DNA replication_Homo sapiens_hsa030300.89559784
66Small cell lung cancer_Homo sapiens_hsa052220.89266175
67ErbB signaling pathway_Homo sapiens_hsa040120.88521182
68Circadian rhythm_Homo sapiens_hsa047100.85856596
69Thyroid cancer_Homo sapiens_hsa052160.85039325
70Dorso-ventral axis formation_Homo sapiens_hsa043200.83657324
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82921612
72Cyanoamino acid metabolism_Homo sapiens_hsa004600.82627062
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.82526107
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.81631619
75Thyroid hormone synthesis_Homo sapiens_hsa049180.80183244
76Wnt signaling pathway_Homo sapiens_hsa043100.79477849
77Prostate cancer_Homo sapiens_hsa052150.79395458
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78605744
79Cardiac muscle contraction_Homo sapiens_hsa042600.78089234
80Dilated cardiomyopathy_Homo sapiens_hsa054140.77122214
81MAPK signaling pathway_Homo sapiens_hsa040100.77094605
82VEGF signaling pathway_Homo sapiens_hsa043700.76879823
83Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75809963
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.75095404
85Focal adhesion_Homo sapiens_hsa045100.75060584
86Hedgehog signaling pathway_Homo sapiens_hsa043400.74709526
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.72306225
88Proteoglycans in cancer_Homo sapiens_hsa052050.71935270
89Pancreatic secretion_Homo sapiens_hsa049720.70968840
90Prolactin signaling pathway_Homo sapiens_hsa049170.70635205
91mTOR signaling pathway_Homo sapiens_hsa041500.68214871
92Choline metabolism in cancer_Homo sapiens_hsa052310.66512479
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.66058930
94Inositol phosphate metabolism_Homo sapiens_hsa005620.65714299
95Pathways in cancer_Homo sapiens_hsa052000.64994539
96Fanconi anemia pathway_Homo sapiens_hsa034600.64989609
97Central carbon metabolism in cancer_Homo sapiens_hsa052300.62994681
98mRNA surveillance pathway_Homo sapiens_hsa030150.62088317
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59420987
100Type I diabetes mellitus_Homo sapiens_hsa049400.58498039
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.57980971
102Rap1 signaling pathway_Homo sapiens_hsa040150.56424943
103Vitamin B6 metabolism_Homo sapiens_hsa007500.56114735
104Fatty acid biosynthesis_Homo sapiens_hsa000610.55645496
105Hepatitis B_Homo sapiens_hsa051610.55403084
106Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55167920
107Viral carcinogenesis_Homo sapiens_hsa052030.54010930
108Hippo signaling pathway_Homo sapiens_hsa043900.53492551
109Non-small cell lung cancer_Homo sapiens_hsa052230.53460640
110Colorectal cancer_Homo sapiens_hsa052100.53364052
111FoxO signaling pathway_Homo sapiens_hsa040680.53323292
112B cell receptor signaling pathway_Homo sapiens_hsa046620.52601825
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51986213
114Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51899385
115Ras signaling pathway_Homo sapiens_hsa040140.51784218
116Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.50999031
117Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50687535
118Endometrial cancer_Homo sapiens_hsa052130.50171955
119Melanoma_Homo sapiens_hsa052180.49841053
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49070009
121Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48740258
122Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48687590
123HIF-1 signaling pathway_Homo sapiens_hsa040660.48599875
124ECM-receptor interaction_Homo sapiens_hsa045120.47498832
125T cell receptor signaling pathway_Homo sapiens_hsa046600.47175587
126HTLV-I infection_Homo sapiens_hsa051660.47159394
127Endocytosis_Homo sapiens_hsa041440.46779976
128Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46394842
129Basal cell carcinoma_Homo sapiens_hsa052170.44086348
130Renal cell carcinoma_Homo sapiens_hsa052110.43860974
131Tight junction_Homo sapiens_hsa045300.38604358
132Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.37990741
133Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36008536
134Insulin signaling pathway_Homo sapiens_hsa049100.33045670
135Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30333532
136Ovarian steroidogenesis_Homo sapiens_hsa049130.29144168
137Sphingolipid signaling pathway_Homo sapiens_hsa040710.28644938
138Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.26751949
139Adherens junction_Homo sapiens_hsa045200.26621349
140Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.24812352
141Regulation of actin cytoskeleton_Homo sapiens_hsa048100.23870310
142AMPK signaling pathway_Homo sapiens_hsa041520.23488066
143MicroRNAs in cancer_Homo sapiens_hsa052060.23145590

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