NPFF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the FMRFamide related peptide (FARP) family of neuropeptides. The encoded preproprotein is proteolytically processed to generate multiple amidated peptides. These peptides may play a role in the regulation of heart rate and blood pressure and the modulation of morphine-induced antinociception. Patients with hypertension exhibit decreased expression of the encoded protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline metabolic process (GO:0006560)8.82253031
2transcription from mitochondrial promoter (GO:0006390)8.73215805
3embryonic process involved in female pregnancy (GO:0060136)8.39371624
4replication fork processing (GO:0031297)7.77221567
5positive regulation of protein homooligomerization (GO:0032464)7.51161801
6oxidative demethylation (GO:0070989)6.96673110
7regulation of integrin activation (GO:0033623)6.92240520
8DNA deamination (GO:0045006)6.57931397
9establishment of apical/basal cell polarity (GO:0035089)6.53015300
10regulation of protein homooligomerization (GO:0032462)6.41618993
11maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)6.18971100
12regulation of meiosis I (GO:0060631)5.70873610
13establishment of monopolar cell polarity (GO:0061162)5.63066440
14establishment or maintenance of monopolar cell polarity (GO:0061339)5.63066440
15mitochondrial DNA metabolic process (GO:0032042)5.61766329
16regulation of DNA endoreduplication (GO:0032875)5.52835978
17poly(A)+ mRNA export from nucleus (GO:0016973)5.50559992
18resolution of meiotic recombination intermediates (GO:0000712)5.46962034
19DNA strand renaturation (GO:0000733)5.44073330
20protein polyglutamylation (GO:0018095)5.33371305
21ribosomal small subunit assembly (GO:0000028)5.31338850
22regulation of cilium movement (GO:0003352)5.22017378
23mitotic G1 DNA damage checkpoint (GO:0031571)5.19754242
24somatic diversification of immune receptors via somatic mutation (GO:0002566)5.19638538
25somatic hypermutation of immunoglobulin genes (GO:0016446)5.19638538
26negative regulation of JAK-STAT cascade (GO:0046426)5.19149182
27cellular response to ATP (GO:0071318)5.15922066
28embryonic placenta development (GO:0001892)5.02743182
29glutamine family amino acid biosynthetic process (GO:0009084)4.84335553
30viral transcription (GO:0019083)4.69969044
31mRNA cleavage (GO:0006379)4.68559370
32mitotic G1/S transition checkpoint (GO:0044819)4.67399728
33G1 DNA damage checkpoint (GO:0044783)4.67122943
34viral mRNA export from host cell nucleus (GO:0046784)4.64435444
35cellular response to zinc ion (GO:0071294)4.61370689
36negative regulation of protein oligomerization (GO:0032460)4.60392193
37negative regulation of cell cycle arrest (GO:0071157)4.60385219
38mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.59479461
39translational termination (GO:0006415)4.56127684
40negative regulation of fatty acid biosynthetic process (GO:0045717)4.49331245
41negative regulation of Ras GTPase activity (GO:0034261)4.44832320
42positive regulation of developmental pigmentation (GO:0048087)4.42908223
43regulation of translational fidelity (GO:0006450)4.40368182
44mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.39210272
45embryonic camera-type eye development (GO:0031076)4.35388970
46establishment of protein localization to mitochondrial membrane (GO:0090151)4.35170200
47positive regulation of protein oligomerization (GO:0032461)4.28334955
48neurofilament cytoskeleton organization (GO:0060052)4.23689460
49DNA integration (GO:0015074)4.20984211
50piRNA metabolic process (GO:0034587)4.19778188
51convergent extension (GO:0060026)4.14759388
52regulation of protein oligomerization (GO:0032459)4.14303332
53spliceosomal tri-snRNP complex assembly (GO:0000244)4.13069559
54male meiosis I (GO:0007141)4.11957400
55negative regulation of DNA-dependent DNA replication (GO:2000104)4.08937096
56tachykinin receptor signaling pathway (GO:0007217)4.07303858
57protein neddylation (GO:0045116)4.04195466
58regulation of nuclear cell cycle DNA replication (GO:0033262)4.01393893
59base-excision repair (GO:0006284)4.00450496
60negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.99984613
61glial cell migration (GO:0008347)3.99783334
62positive regulation by host of viral transcription (GO:0043923)3.98969918
63face development (GO:0060324)3.95457638
64apoptotic process involved in morphogenesis (GO:0060561)3.94389692
65ATP synthesis coupled proton transport (GO:0015986)3.94085385
66energy coupled proton transport, down electrochemical gradient (GO:0015985)3.94085385
67negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.89827152
68base-excision repair, AP site formation (GO:0006285)3.87768018
69double-strand break repair via nonhomologous end joining (GO:0006303)3.87709558
70non-recombinational repair (GO:0000726)3.87709558
71ribosomal small subunit biogenesis (GO:0042274)3.85033263
72regulation of microtubule-based movement (GO:0060632)3.80690874
73regulation of RNA export from nucleus (GO:0046831)3.76270868
74positive regulation of gastrulation (GO:2000543)3.75564062
75electron transport chain (GO:0022900)3.75367732
76respiratory electron transport chain (GO:0022904)3.74859400
77epithelial cilium movement (GO:0003351)3.66561137
78mitochondrial RNA metabolic process (GO:0000959)3.66422902
79cotranslational protein targeting to membrane (GO:0006613)3.64352059
80formation of translation preinitiation complex (GO:0001731)3.63661157
81anatomical structure regression (GO:0060033)3.61037210
82SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.60042823
83protein targeting to ER (GO:0045047)3.59397419
84dosage compensation (GO:0007549)3.58539129
85cellular protein complex disassembly (GO:0043624)3.56271066
86epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.56242833
87labyrinthine layer development (GO:0060711)3.55776072
88pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.55244948
89histone H4-K12 acetylation (GO:0043983)3.55072354
90DNA topological change (GO:0006265)3.54078583
91negative regulation of mRNA processing (GO:0050686)3.52528000
92DNA double-strand break processing (GO:0000729)3.51801490
93proteasome assembly (GO:0043248)3.51449123
94translational elongation (GO:0006414)3.51139194
95behavioral response to nicotine (GO:0035095)3.49591572
96meiosis I (GO:0007127)3.47906807
97positive regulation of mitotic sister chromatid separation (GO:1901970)3.47631434
98positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.47631434
99positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.47631434
100olfactory bulb development (GO:0021772)3.47561953
101establishment of protein localization to endoplasmic reticulum (GO:0072599)3.44857677
102microtubule severing (GO:0051013)3.44213586
103positive regulation of DNA repair (GO:0045739)3.43862999
104alkaloid metabolic process (GO:0009820)3.43381345
105establishment of protein localization to vacuole (GO:0072666)3.42253537
106protein targeting to vacuole (GO:0006623)3.42253537
107protein targeting to lysosome (GO:0006622)3.42253537
108trophectodermal cell differentiation (GO:0001829)3.40896536
109activation of Rac GTPase activity (GO:0032863)3.40029243
110regulation of cAMP-dependent protein kinase activity (GO:2000479)3.39760844
111regulation of mitochondrial depolarization (GO:0051900)3.38681793
112DNA demethylation (GO:0080111)3.38465151
113protein localization to endoplasmic reticulum (GO:0070972)3.37174315
114telomere maintenance via semi-conservative replication (GO:0032201)3.36294596
115signal complex assembly (GO:0007172)3.35456957
116regulation of sister chromatid cohesion (GO:0007063)3.34923563
117positive regulation of receptor recycling (GO:0001921)3.34423675
118meiotic chromosome segregation (GO:0045132)3.34103546
119DNA ligation (GO:0006266)3.32755261
120sulfur amino acid catabolic process (GO:0000098)3.32740627
121nuclear envelope reassembly (GO:0031468)3.32116835
122mitotic nuclear envelope reassembly (GO:0007084)3.32116835
123hypotonic response (GO:0006971)3.31409692
124GDP-mannose metabolic process (GO:0019673)3.30443973
125nucleotide-excision repair, DNA gap filling (GO:0006297)3.30221709
126nodal signaling pathway (GO:0038092)3.30115619
127single strand break repair (GO:0000012)3.29147631
128termination of RNA polymerase II transcription (GO:0006369)3.28748212
129cerebral cortex neuron differentiation (GO:0021895)3.26680109
130regulation of podosome assembly (GO:0071801)3.25466386
131motile cilium assembly (GO:0044458)3.25210901
132maturation of SSU-rRNA (GO:0030490)3.24273820
133negative regulation of tumor necrosis factor production (GO:0032720)3.23756570
134viral life cycle (GO:0019058)3.22945230
135cell proliferation in forebrain (GO:0021846)3.21113763
136maturation of 5.8S rRNA (GO:0000460)3.20924329
137regulation of response to reactive oxygen species (GO:1901031)3.19699880
138very-low-density lipoprotein particle assembly (GO:0034379)3.19445690
139regulation of cell size (GO:0008361)3.19035414
140auditory receptor cell stereocilium organization (GO:0060088)3.18891124
141translational initiation (GO:0006413)3.18242259
142nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.17800322
143regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.16045072
144negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)3.11982151
145protein localization to endosome (GO:0036010)3.11389011
146chaperone-mediated protein transport (GO:0072321)3.11137462
147DNA methylation involved in gamete generation (GO:0043046)3.09869465
148ventricular trabecula myocardium morphogenesis (GO:0003222)3.08288033
149seminiferous tubule development (GO:0072520)3.07825454
150cilium movement (GO:0003341)3.04929313
151centriole replication (GO:0007099)3.01932654
152fucose catabolic process (GO:0019317)3.01855470
153L-fucose metabolic process (GO:0042354)3.01855470
154L-fucose catabolic process (GO:0042355)3.01855470
155sperm motility (GO:0030317)3.00947162
156dentate gyrus development (GO:0021542)2.98771683
157protein complex disassembly (GO:0043241)2.97636227
158macromolecular complex disassembly (GO:0032984)2.93596620
159regulation of monocyte differentiation (GO:0045655)2.90917255
160microtubule bundle formation (GO:0001578)2.90237382
161regulation of timing of cell differentiation (GO:0048505)2.88648494
162DNA-dependent DNA replication (GO:0006261)2.86698287
163postsynaptic membrane organization (GO:0001941)2.85913718
164protein complex biogenesis (GO:0070271)2.85049808
165kinetochore assembly (GO:0051382)2.80794824
166pyrimidine nucleotide catabolic process (GO:0006244)2.79400801
167neuromuscular process controlling posture (GO:0050884)2.78409719
168heterochromatin organization (GO:0070828)2.76347057
169negative regulation of macrophage differentiation (GO:0045650)2.74767607
170substrate-independent telencephalic tangential migration (GO:0021826)2.74400294
171substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.74400294
172pyrimidine dimer repair (GO:0006290)2.67118531
173microtubule nucleation (GO:0007020)2.67040055
174regulation of centriole replication (GO:0046599)2.65598756
175oxidative phosphorylation (GO:0006119)2.64938537
176synapsis (GO:0007129)2.64726516
177mismatch repair (GO:0006298)2.63440777
178RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.62911202
179tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.62911202
180gonadal mesoderm development (GO:0007506)2.61516909
181presynaptic membrane organization (GO:0097090)2.59417195
182kinetochore organization (GO:0051383)2.59088009
183ventricular cardiac muscle cell development (GO:0055015)2.58744652
184positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.57914576
185presynaptic membrane assembly (GO:0097105)2.57549767
186establishment of protein localization to mitochondrion (GO:0072655)2.56715598
187negative regulation of meiosis (GO:0045835)2.56397046
188positive regulation of action potential (GO:0045760)2.55889125
189deoxyribonucleotide catabolic process (GO:0009264)2.55379108
190anterograde synaptic vesicle transport (GO:0048490)2.55178780
191mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.53710094
192mitochondrial respiratory chain complex I assembly (GO:0032981)2.53710094
193NADH dehydrogenase complex assembly (GO:0010257)2.53710094
194adaptation of signaling pathway (GO:0023058)2.53575619
195proline biosynthetic process (GO:0006561)11.4831564

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.90651103
2EZH2_22144423_ChIP-Seq_EOC_Human4.30426780
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.08713751
4SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.49484270
5ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.42263910
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.38496722
7KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.38496722
8KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.38496722
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.34331286
10RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.20748131
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.16773576
12SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.92159972
13ZNF274_21170338_ChIP-Seq_K562_Hela2.85907701
14VDR_21846776_ChIP-Seq_THP-1_Human2.81557607
15RBPJ_22232070_ChIP-Seq_NCS_Mouse2.73305649
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.65718781
17SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.63285524
18IGF1R_20145208_ChIP-Seq_DFB_Human2.60184767
19BP1_19119308_ChIP-ChIP_Hs578T_Human2.53968045
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.52375027
21CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.47103278
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.44089615
23POU5F1_16518401_ChIP-PET_MESCs_Mouse2.37299260
24NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.37237777
25EST1_17652178_ChIP-ChIP_JURKAT_Human2.36177480
26LXR_22292898_ChIP-Seq_THP-1_Human2.33994399
27DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.33468622
28NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.31703757
29ERG_21242973_ChIP-ChIP_JURKAT_Human2.26863533
30KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.22367295
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.21204387
32VDR_22108803_ChIP-Seq_LS180_Human2.20849689
33CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.20033417
34TCF3_18692474_ChIP-Seq_MESCs_Mouse2.11311619
35ETS1_20019798_ChIP-Seq_JURKAT_Human2.03439956
36EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.03216078
37PU.1_20513432_ChIP-Seq_Bcells_Mouse1.97788199
38SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.97276831
39MYC_18555785_ChIP-Seq_MESCs_Mouse1.91988021
40NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.91664166
41CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.90617778
42JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.85953821
43TCF3_18692474_ChIP-Seq_MEFs_Mouse1.80656160
44NANOG_21062744_ChIP-ChIP_HESCs_Human1.78445538
45REST_21632747_ChIP-Seq_MESCs_Mouse1.74659693
46STAT3_1855785_ChIP-Seq_MESCs_Mouse1.73928797
47ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.71641759
48MYC_19079543_ChIP-ChIP_MESCs_Mouse1.68032943
49RACK7_27058665_Chip-Seq_MCF-7_Human1.67877065
50TET1_21451524_ChIP-Seq_MESCs_Mouse1.66355623
51POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.64441035
52* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.64283056
53AR_21572438_ChIP-Seq_LNCaP_Human1.63824584
54NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.62570466
55* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.62380119
56TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61006135
57POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.61006135
58MYC_22102868_ChIP-Seq_BL_Human1.60595719
59KDM2B_26808549_Chip-Seq_SUP-B15_Human1.58827043
60ZFP281_27345836_Chip-Seq_ESCs_Mouse1.58579221
61PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.56110058
62ZFP281_18757296_ChIP-ChIP_E14_Mouse1.55701475
63HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.54231557
64EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.53907437
65EZH2_27304074_Chip-Seq_ESCs_Mouse1.51721639
66MYC_18358816_ChIP-ChIP_MESCs_Mouse1.49286560
67KDM2B_26808549_Chip-Seq_DND41_Human1.47525689
68SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.45514752
69CBX2_27304074_Chip-Seq_ESCs_Mouse1.45503044
70ZNF263_19887448_ChIP-Seq_K562_Human1.42583643
71CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42536209
72DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.41955515
73GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.41649708
74RXRA_24833708_ChIP-Seq_LIVER_Mouse1.41641883
75KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.41184208
76RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.39546968
77IRF1_19129219_ChIP-ChIP_H3396_Human1.38902703
78BMI1_23680149_ChIP-Seq_NPCS_Mouse1.38763566
79POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.37279894
80SOX2_18555785_ChIP-Seq_MESCs_Mouse1.36954977
81KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.35993804
82SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.35905790
83NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.35753746
84KLF4_18555785_ChIP-Seq_MESCs_Mouse1.34163622
85ESR1_15608294_ChIP-ChIP_MCF-7_Human1.33971681
86ETS1_21867929_ChIP-Seq_TH2_Mouse1.33732313
87IKZF1_21737484_ChIP-ChIP_HCT116_Human1.33599118
88SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32593930
89CREB1_15753290_ChIP-ChIP_HEK293T_Human1.30045933
90SALL1_21062744_ChIP-ChIP_HESCs_Human1.29435224
91NANOG_18692474_ChIP-Seq_MESCs_Mouse1.29007988
92TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28429180
93RARB_24833708_ChIP-Seq_LIVER_Mouse1.26650869
94GATA3_21878914_ChIP-Seq_MCF-7_Human1.25905491
95NANOG_18555785_ChIP-Seq_MESCs_Mouse1.25387919
96PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.23594359
97SOX2_18692474_ChIP-Seq_MESCs_Mouse1.22870124
98CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21319671
99BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.20332384
100* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.20024853
101NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.19803599
102* ELK3_25401928_ChIP-Seq_HUVEC_Human1.18691389
103EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.18426796
104SOX2_16153702_ChIP-ChIP_HESCs_Human1.18014578
105MYC_19030024_ChIP-ChIP_MESCs_Mouse1.17954948
106SRY_22984422_ChIP-ChIP_TESTIS_Rat1.16625135
107SOX2_18692474_ChIP-Seq_MEFs_Mouse1.16580465
108RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.16083106
109CDX2_20551321_ChIP-Seq_CACO-2_Human1.15960510
110POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.15688767
111REST_18959480_ChIP-ChIP_MESCs_Mouse1.15335035
112SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.15098601
113GBX2_23144817_ChIP-Seq_PC3_Human1.14159548
114THAP11_20581084_ChIP-Seq_MESCs_Mouse1.14148426
115* SPI1_26923725_Chip-Seq_HPCs_Mouse1.13709524
116P300_27058665_Chip-Seq_ZR-75-30cells_Human1.12881857
117RARA_24833708_ChIP-Seq_LIVER_Mouse1.12761579
118CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.12646407
119PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.12527602
120STAT1_20625510_ChIP-Seq_HELA_Human1.11456253
121FOXM1_23109430_ChIP-Seq_U2OS_Human1.11267804
122TP63_17297297_ChIP-ChIP_HaCaT_Human1.11233743
123MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.10265573
124TP53_20018659_ChIP-ChIP_R1E_Mouse1.10142440
125SRF_21415370_ChIP-Seq_HL-1_Mouse1.09986109
126NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.09742186
127BCOR_27268052_Chip-Seq_Bcells_Human1.09383288
128* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.08590839
129TP63_19390658_ChIP-ChIP_HaCaT_Human1.07168036
130TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.07062338
131FUS_26573619_Chip-Seq_HEK293_Human1.06565191
132TAF15_26573619_Chip-Seq_HEK293_Human1.06370245
133YY1_21170310_ChIP-Seq_MESCs_Mouse1.06275086
134KDM2B_26808549_Chip-Seq_K562_Human1.06165530
135OCT4_18692474_ChIP-Seq_MEFs_Mouse1.05666657
136PHF8_20622854_ChIP-Seq_HELA_Human1.05007343
137TDRD3_21172665_ChIP-Seq_MCF-7_Human1.04994490
138E2F1_20622854_ChIP-Seq_HELA_Human1.04882997
139ETV2_25802403_ChIP-Seq_MESCs_Mouse1.04449266
140NANOG_16518401_ChIP-PET_MESCs_Mouse1.04016016
141TP53_22573176_ChIP-Seq_HFKS_Human1.03736810
142RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.03644606
143POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03394148
144CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02023596
145ERA_21632823_ChIP-Seq_H3396_Human1.01723927
146EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.01463455
147THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.01266917
148JARID2_20064375_ChIP-Seq_MESCs_Mouse1.01256560
149SUZ12_27294783_Chip-Seq_ESCs_Mouse1.01200117
150* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.00371071
151CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00091699
152EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.00069016
153E2F1_18555785_ChIP-Seq_MESCs_Mouse0.99911568
154BCAT_22108803_ChIP-Seq_LS180_Human0.99740259
155MYC_19829295_ChIP-Seq_ESCs_Human0.99611869
156VDR_24763502_ChIP-Seq_THP-1_Human0.97915338
157PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.97774134
158SA1_27219007_Chip-Seq_ERYTHROID_Human0.97446495
159KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.97026140
160GATA1_22383799_ChIP-Seq_G1ME_Mouse0.96306402
161HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.96203688
162CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.95762371
163SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.95571905
164CTBP2_25329375_ChIP-Seq_LNCAP_Human0.95489832
165CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.95371431
166VDR_23849224_ChIP-Seq_CD4+_Human0.95286115
167* CTCF_27219007_Chip-Seq_Bcells_Human0.94506594
168NANOG_19829295_ChIP-Seq_ESCs_Human0.94168677
169SOX2_19829295_ChIP-Seq_ESCs_Human0.94168677
170ELK1_19687146_ChIP-ChIP_HELA_Human0.92138243
171RBPJ_21746931_ChIP-Seq_IB4_Human0.92131468
172NANOG_20526341_ChIP-Seq_ESCs_Human0.89074539
173E2F1_17053090_ChIP-ChIP_MCF-7_Human0.87827634
174YY1_22570637_ChIP-Seq_MALME-3M_Human0.87403267
175VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.87039794
176WDR5_24793694_ChIP-Seq_LNCAP_Human0.86584378
177FOXP3_21729870_ChIP-Seq_TREG_Human0.85737639
178NCOR_22424771_ChIP-Seq_293T_Human0.85246047
179OCT4_19829295_ChIP-Seq_ESCs_Human0.84843905
180NFE2_27457419_Chip-Seq_LIVER_Mouse0.83742710
181MYC_18940864_ChIP-ChIP_HL60_Human0.83553285
182POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.82648908
183ZFP57_27257070_Chip-Seq_ESCs_Mouse0.82465681
184GABP_19822575_ChIP-Seq_HepG2_Human0.82140936
185FOXH1_21741376_ChIP-Seq_EPCs_Human0.81079738
186TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80673778
187P300_19829295_ChIP-Seq_ESCs_Human0.80264164
188RNF2_27304074_Chip-Seq_NSC_Mouse0.79740844
189FOXA1_27270436_Chip-Seq_PROSTATE_Human0.78740858

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication6.10001886
2MP0005171_absent_coat_pigmentation5.58202183
3MP0009278_abnormal_bone_marrow4.90981598
4MP0010030_abnormal_orbit_morphology4.27224439
5MP0004233_abnormal_muscle_weight3.77895857
6MP0002009_preneoplasia3.68536359
7MP0006292_abnormal_olfactory_placode3.50156580
8MP0009379_abnormal_foot_pigmentation3.40650109
9MP0003123_paternal_imprinting3.04259757
10MP0008995_early_reproductive_senescence2.72817437
11MP0003787_abnormal_imprinting2.70082772
12MP0006276_abnormal_autonomic_nervous2.50852605
13MP0003283_abnormal_digestive_organ2.40974256
14MP0005174_abnormal_tail_pigmentation2.37793949
15MP0003646_muscle_fatigue2.25173745
16MP0005397_hematopoietic_system_phenotyp2.24254209
17MP0001545_abnormal_hematopoietic_system2.24254209
18MP0002249_abnormal_larynx_morphology2.21156034
19MP0004133_heterotaxia2.20743779
20MP0004885_abnormal_endolymph2.19337974
21MP0003890_abnormal_embryonic-extraembry2.16106808
22MP0006072_abnormal_retinal_apoptosis2.13351496
23MP0003453_abnormal_keratinocyte_physiol2.11359397
24MP0001968_abnormal_touch/_nociception2.08644078
25MP0000778_abnormal_nervous_system2.08539315
26MP0002736_abnormal_nociception_after2.04456302
27MP0010368_abnormal_lymphatic_system2.01679653
28MP0003806_abnormal_nucleotide_metabolis2.00326922
29MP0002160_abnormal_reproductive_system1.98278333
30MP0005551_abnormal_eye_electrophysiolog1.97449773
31MP0003119_abnormal_digestive_system1.92401595
32MP0000631_abnormal_neuroendocrine_gland1.91336766
33MP0000579_abnormal_nail_morphology1.89673256
34MP0001485_abnormal_pinna_reflex1.84650707
35MP0010094_abnormal_chromosome_stability1.83506277
36MP0003786_premature_aging1.82950174
37MP0000569_abnormal_digit_pigmentation1.80516653
38MP0002653_abnormal_ependyma_morphology1.79098069
39MP0004742_abnormal_vestibular_system1.77774085
40MP0005076_abnormal_cell_differentiation1.77531004
41MP0003880_abnormal_central_pattern1.76040920
42MP0002282_abnormal_trachea_morphology1.75145910
43MP0002938_white_spotting1.71956831
44MP0009764_decreased_sensitivity_to1.67509153
45MP0001293_anophthalmia1.66799244
46MP0002210_abnormal_sex_determination1.65433674
47MP0002272_abnormal_nervous_system1.63986354
48MP0008789_abnormal_olfactory_epithelium1.63380844
49MP0003172_abnormal_lysosome_physiology1.62754400
50MP0004145_abnormal_muscle_electrophysio1.60816869
51MP0000015_abnormal_ear_pigmentation1.54619345
52MP0000371_diluted_coat_color1.52686770
53MP0002735_abnormal_chemical_nociception1.52037147
54MP0002086_abnormal_extraembryonic_tissu1.51600465
55MP0005075_abnormal_melanosome_morpholog1.51372509
56MP0005394_taste/olfaction_phenotype1.44546451
57MP0005499_abnormal_olfactory_system1.44546451
58MP0002084_abnormal_developmental_patter1.44435016
59MP0000470_abnormal_stomach_morphology1.43488419
60MP0005058_abnormal_lysosome_morphology1.42965080
61MP0000462_abnormal_digestive_system1.41393824
62MP0001727_abnormal_embryo_implantation1.38719868
63MP0001529_abnormal_vocalization1.38605886
64MP0010352_gastrointestinal_tract_polyps1.35750303
65MP0002557_abnormal_social/conspecific_i1.34753546
66MP0002269_muscular_atrophy1.32301105
67MP0004270_analgesia1.31730316
68MP0004197_abnormal_fetal_growth/weight/1.30563165
69MP0001697_abnormal_embryo_size1.30232889
70MP0002085_abnormal_embryonic_tissue1.29615346
71MP0002184_abnormal_innervation1.29379780
72MP0003121_genomic_imprinting1.28813208
73MP0001340_abnormal_eyelid_morphology1.28584508
74MP0002796_impaired_skin_barrier1.28573581
75MP0005085_abnormal_gallbladder_physiolo1.28090436
76MP0003698_abnormal_male_reproductive1.27879007
77MP0002067_abnormal_sensory_capabilities1.27458858
78MP0004957_abnormal_blastocyst_morpholog1.25634869
79MP0000639_abnormal_adrenal_gland1.25596565
80MP0003878_abnormal_ear_physiology1.25479530
81MP0005377_hearing/vestibular/ear_phenot1.25479530
82MP0009745_abnormal_behavioral_response1.24889145
83MP0000490_abnormal_crypts_of1.22945972
84MP0008877_abnormal_DNA_methylation1.22851469
85MP0005389_reproductive_system_phenotype1.21875360
86MP0003567_abnormal_fetal_cardiomyocyte1.21068522
87MP0002752_abnormal_somatic_nervous1.20242474
88MP0001970_abnormal_pain_threshold1.18166207
89MP0003635_abnormal_synaptic_transmissio1.17858487
90MP0005410_abnormal_fertilization1.17741624
91MP0002111_abnormal_tail_morphology1.17430073
92MP0001145_abnormal_male_reproductive1.17124114
93MP0003828_pulmonary_edema1.16972013
94MP0008058_abnormal_DNA_repair1.16695125
95MP0008932_abnormal_embryonic_tissue1.16436031
96MP0002882_abnormal_neuron_morphology1.15597644
97MP0000955_abnormal_spinal_cord1.15507763
98MP0003941_abnormal_skin_development1.15459207
99MP0000762_abnormal_tongue_morphology1.14756285
100MP0002277_abnormal_respiratory_mucosa1.14415192
101MP0000685_abnormal_immune_system1.13752550
102MP0001929_abnormal_gametogenesis1.13426013
103MP0009053_abnormal_anal_canal1.12630987
104MP0002095_abnormal_skin_pigmentation1.10540303
105MP0001963_abnormal_hearing_physiology1.09073960
106MP0002837_dystrophic_cardiac_calcinosis1.07756873
107MP0002932_abnormal_joint_morphology1.07044361
108MP0002734_abnormal_mechanical_nocicepti1.06817945
109MP0003045_fibrosis1.06719515
110MP0009046_muscle_twitch1.06476549
111MP0002572_abnormal_emotion/affect_behav1.06263265
112MP0009765_abnormal_xenobiotic_induced1.05381104
113MP0005365_abnormal_bile_salt1.04625543
114MP0005423_abnormal_somatic_nervous1.03245913
115MP0000653_abnormal_sex_gland1.02440934
116MP0008872_abnormal_physiological_respon1.00762807
117MP0004811_abnormal_neuron_physiology1.00287302
118MP0005380_embryogenesis_phenotype0.99877979
119MP0001672_abnormal_embryogenesis/_devel0.99877979
120MP0002063_abnormal_learning/memory/cond0.99017080
121MP0002060_abnormal_skin_morphology0.98056523
122MP0003111_abnormal_nucleus_morphology0.97668094
123MP0002733_abnormal_thermal_nociception0.97259559
124MP0002075_abnormal_coat/hair_pigmentati0.95886049
125MP0006035_abnormal_mitochondrial_morpho0.95538493
126MP0003755_abnormal_palate_morphology0.94491607
127MP0008260_abnormal_autophagy0.94112742
128MP0002751_abnormal_autonomic_nervous0.93546299
129MP0009115_abnormal_fat_cell0.93224454
130MP0000026_abnormal_inner_ear0.92812459
131MP0002822_catalepsy0.91988662
132MP0005195_abnormal_posterior_eye0.91424149
133MP0003935_abnormal_craniofacial_develop0.91240821
134MP0001324_abnormal_eye_pigmentation0.90776931
135MP0003879_abnormal_hair_cell0.89544007
136MP0002114_abnormal_axial_skeleton0.88679013
137MP0003137_abnormal_impulse_conducting0.88473305
138MP0003183_abnormal_peptide_metabolism0.88299598
139MP0001188_hyperpigmentation0.87329609
140MP0006082_CNS_inflammation0.87275599
141MP0002019_abnormal_tumor_incidence0.85855537
142MP0003861_abnormal_nervous_system0.84788758
143MP0004264_abnormal_extraembryonic_tissu0.84268360
144MP0002163_abnormal_gland_morphology0.83616172
145MP0002152_abnormal_brain_morphology0.82556101
146MP0002405_respiratory_system_inflammati0.81321509
147MP0005645_abnormal_hypothalamus_physiol0.81247073
148MP0005330_cardiomyopathy0.81104134
149MP0001186_pigmentation_phenotype0.80237419
150MP0002116_abnormal_craniofacial_bone0.79657839
151MP0000467_abnormal_esophagus_morphology0.79075533
152MP0003136_yellow_coat_color0.78921822
153MP0005266_abnormal_metabolism0.78669623
154MP0001905_abnormal_dopamine_level0.78257122
155MP0000516_abnormal_urinary_system0.77569378
156MP0005367_renal/urinary_system_phenotyp0.77569378
157MP0004142_abnormal_muscle_tone0.75407696
158MP0000350_abnormal_cell_proliferation0.75090763
159MP0002080_prenatal_lethality0.74905417
160MP0003718_maternal_effect0.74520326
161MP0005501_abnormal_skin_physiology0.73929445
162MP0000432_abnormal_head_morphology0.73811106
163MP0003656_abnormal_erythrocyte_physiolo0.73415400
164MP0010630_abnormal_cardiac_muscle0.72189399
165MP0005508_abnormal_skeleton_morphology0.71310828
166MP0002229_neurodegeneration0.70989205
167MP0002064_seizures0.70871407
168MP0001486_abnormal_startle_reflex0.70486483
169MP0002332_abnormal_exercise_endurance0.70175527
170MP0003984_embryonic_growth_retardation0.69750767
171MP0001177_atelectasis0.69569418
172MP0003936_abnormal_reproductive_system0.69384423
173MP0001730_embryonic_growth_arrest0.68949695
174MP0003938_abnormal_ear_development0.68891125
175MP0004134_abnormal_chest_morphology0.67876783
176MP0002088_abnormal_embryonic_growth/wei0.65305434
177MP0002166_altered_tumor_susceptibility0.64798971
178MP0001784_abnormal_fluid_regulation0.63294667
179MP0000049_abnormal_middle_ear0.63080564
180MP0004185_abnormal_adipocyte_glucose0.62225546
181MP0003077_abnormal_cell_cycle0.61705117
182MP0002970_abnormal_white_adipose0.59440591
183MP0005253_abnormal_eye_physiology0.58714509
184MP0003385_abnormal_body_wall0.58501896
185MP0005391_vision/eye_phenotype0.58206546
186MP0004019_abnormal_vitamin_homeostasis0.57621481

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)5.70176924
2Concave nail (HP:0001598)5.48542940
3Pustule (HP:0200039)5.33633733
4Annular pancreas (HP:0001734)5.12331459
5Rectal fistula (HP:0100590)5.09027960
6Rectovaginal fistula (HP:0000143)5.09027960
7Turricephaly (HP:0000262)5.06984031
8Facial hemangioma (HP:0000329)5.04028677
9Increased IgM level (HP:0003496)4.98944217
10Alopecia of scalp (HP:0002293)4.84341871
11Intestinal fistula (HP:0100819)4.70058153
12Vaginal fistula (HP:0004320)4.55245539
13Poikiloderma (HP:0001029)4.54785990
14Hypochromic microcytic anemia (HP:0004840)4.53460342
15Coronal craniosynostosis (HP:0004440)4.52219958
16Acute necrotizing encephalopathy (HP:0006965)4.48191089
17Ulnar bowing (HP:0003031)4.47891593
18Abnormality of cells of the erythroid lineage (HP:0012130)4.21771139
19Nephronophthisis (HP:0000090)4.06800689
20Alacrima (HP:0000522)4.05395276
21Abnormal mitochondria in muscle tissue (HP:0008316)4.04641622
22Absent/shortened dynein arms (HP:0200106)3.85161381
23Dynein arm defect of respiratory motile cilia (HP:0012255)3.85161381
24Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.82949648
25Male infertility (HP:0003251)3.80205664
26Tongue fasciculations (HP:0001308)3.78422209
27Abnormal number of erythroid precursors (HP:0012131)3.78312403
28Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.75369882
29Anteriorly placed anus (HP:0001545)3.73641958
30Acute encephalopathy (HP:0006846)3.66452002
31Short humerus (HP:0005792)3.65783631
32Abnormal hemoglobin (HP:0011902)3.57668671
33Orthostatic hypotension (HP:0001278)3.56152247
34Renal Fanconi syndrome (HP:0001994)3.52132423
35Muscle fibrillation (HP:0010546)3.48695771
36Aplasia/hypoplasia of the humerus (HP:0006507)3.47026640
37Reticulocytopenia (HP:0001896)3.44226305
38Mitochondrial inheritance (HP:0001427)3.43415492
39Progressive macrocephaly (HP:0004481)3.41255219
40Increased CSF lactate (HP:0002490)3.37710652
41Intestinal atresia (HP:0011100)3.36677297
42Abnormality of male internal genitalia (HP:0000022)3.30399244
43Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.30111728
44Vertebral hypoplasia (HP:0008417)3.30111728
45Mucopolysacchariduria (HP:0008155)3.26861710
46Urinary glycosaminoglycan excretion (HP:0003541)3.26861710
47Increased hepatocellular lipid droplets (HP:0006565)3.26568608
48Premature skin wrinkling (HP:0100678)3.25959078
49Congenital hip dislocation (HP:0001374)3.24891901
50Pancreatic fibrosis (HP:0100732)3.23289777
51Absent radius (HP:0003974)3.14927682
52Short chin (HP:0000331)3.14115647
53Agnosia (HP:0010524)3.13838304
54Lipid accumulation in hepatocytes (HP:0006561)3.09432270
55Abnormality of the renal medulla (HP:0100957)3.08808844
56Large for gestational age (HP:0001520)3.06865213
57Dysautonomia (HP:0002459)3.05337477
58Decreased lacrimation (HP:0000633)3.03162648
59Albinism (HP:0001022)2.99876205
60Broad alveolar ridges (HP:0000187)2.98997064
61Aplasia involving forearm bones (HP:0009822)2.98618705
62Absent forearm bone (HP:0003953)2.98618705
63Diaphragmatic weakness (HP:0009113)2.98160015
64Abnormality of mucopolysaccharide metabolism (HP:0011020)2.94493607
65Abnormality of polysaccharide metabolism (HP:0011012)2.94493607
66Abnormality of glycosaminoglycan metabolism (HP:0004371)2.94493607
67Neoplasm of the adrenal cortex (HP:0100641)2.93740458
68Dysostosis multiplex (HP:0000943)2.91558347
69Hypotrichosis (HP:0001006)2.91350603
70Squamous cell carcinoma (HP:0002860)2.91161372
71Abnormality of midbrain morphology (HP:0002418)2.90350965
72Molar tooth sign on MRI (HP:0002419)2.90350965
73Pancreatic islet-cell hyperplasia (HP:0004510)2.89705010
74Hypochromic anemia (HP:0001931)2.89120070
75Hamartoma (HP:0010566)2.88944599
76Absent rod-and cone-mediated responses on ERG (HP:0007688)2.88503454
77Poor suck (HP:0002033)2.85281908
78Abnormal respiratory epithelium morphology (HP:0012253)2.81453244
79Abnormal respiratory motile cilium morphology (HP:0005938)2.81453244
80Abnormal ciliary motility (HP:0012262)2.79547859
81Abnormality of the aortic arch (HP:0012303)2.79354522
82Rhinitis (HP:0012384)2.77189308
83Abnormal respiratory motile cilium physiology (HP:0012261)2.76095542
84Basal cell carcinoma (HP:0002671)2.72924612
85Clumsiness (HP:0002312)2.69737057
86Cerebral edema (HP:0002181)2.69073855
87Bifid uvula (HP:0000193)2.66258425
88Growth hormone excess (HP:0000845)2.65573645
89Joint stiffness (HP:0001387)2.63919972
90Absent thumb (HP:0009777)2.63459972
91Aplasia of the musculature (HP:0100854)2.63164920
92Abnormality of renal resorption (HP:0011038)2.60448670
93Volvulus (HP:0002580)2.59996072
94Agitation (HP:0000713)2.59899239
95Choanal stenosis (HP:0000452)2.58893629
96Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.56818231
97Exertional dyspnea (HP:0002875)2.56262547
98Increased number of teeth (HP:0011069)2.55655456
99Bowed forearm bones (HP:0003956)2.51229690
100Bowing of the arm (HP:0006488)2.51229690
101Hypotelorism (HP:0000601)2.50805964
102Colon cancer (HP:0003003)2.48846596
103Narrow nasal bridge (HP:0000446)2.46630143
104IgA deficiency (HP:0002720)2.46340022
105Polycythemia (HP:0001901)2.46096257
106Cerebral aneurysm (HP:0004944)2.45892345
107Septo-optic dysplasia (HP:0100842)2.43213064
108Severe visual impairment (HP:0001141)2.42204127
109Myokymia (HP:0002411)2.40420327
110Hypokinesia (HP:0002375)2.40241739
111Capillary hemangiomas (HP:0005306)2.39424350
112Amelogenesis imperfecta (HP:0000705)2.39357321
113Premature graying of hair (HP:0002216)2.37968250
114Chronic bronchitis (HP:0004469)2.37165988
115Pancreatic cysts (HP:0001737)2.35836757
116Split hand (HP:0001171)2.35755482
117Acute lymphatic leukemia (HP:0006721)2.33735112
118Selective tooth agenesis (HP:0001592)2.33313195
119True hermaphroditism (HP:0010459)2.28325984
120Optic disc pallor (HP:0000543)2.26905945
121Vertebral fusion (HP:0002948)2.25915499
122Medial flaring of the eyebrow (HP:0010747)2.23056147
123Tubular atrophy (HP:0000092)2.22006300
124Thyroid-stimulating hormone excess (HP:0002925)2.20423014
125Pallor (HP:0000980)2.19510853
126Respiratory difficulties (HP:0002880)2.19180564
127Redundant skin (HP:0001582)2.18768480
128Bulbar palsy (HP:0001283)2.18171915
129Osteomalacia (HP:0002749)2.16882105
130Lower limb hyperreflexia (HP:0002395)2.16824926
131Popliteal pterygium (HP:0009756)2.15939113
132Hypoplasia of the ulna (HP:0003022)2.15880845
133Patellar aplasia (HP:0006443)2.14828374
134Macrocytic anemia (HP:0001972)2.13854266
135Decreased electroretinogram (ERG) amplitude (HP:0000654)2.12648247
136Asymmetric septal hypertrophy (HP:0001670)2.12400441
137Chronic hepatic failure (HP:0100626)2.11838515
138Hypoplasia of the radius (HP:0002984)2.10586234
139Aplasia/Hypoplasia of the sacrum (HP:0008517)2.10493649
140Gastrointestinal atresia (HP:0002589)2.10154643
141Stenosis of the external auditory canal (HP:0000402)2.09942466
142Male pseudohermaphroditism (HP:0000037)2.08704370
143Abnormal rod and cone electroretinograms (HP:0008323)2.06256501
144Glioma (HP:0009733)2.05052690
145Impulsivity (HP:0100710)2.03942024
146Decreased central vision (HP:0007663)2.03041428
147Generalized amyotrophy (HP:0003700)2.02889608
148Decreased activity of mitochondrial respiratory chain (HP:0008972)2.01730257
149Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.01730257
150Anencephaly (HP:0002323)2.01287360
151Cheilitis (HP:0100825)2.00752478
152Congenital, generalized hypertrichosis (HP:0004540)2.00381324
153Ependymoma (HP:0002888)1.98748641
154Hyperphosphaturia (HP:0003109)1.97751041
155Hypercortisolism (HP:0001578)1.94449621
156Aplasia/Hypoplasia of the patella (HP:0006498)1.93029827
157Abnormality of the labia minora (HP:0012880)1.90618978
158Leukodystrophy (HP:0002415)1.90120459
159Muscle fiber atrophy (HP:0100295)1.89879296
160Diminished movement (HP:0002374)1.89611178
161Increased intramyocellular lipid droplets (HP:0012240)1.88761895
162Short 5th finger (HP:0009237)1.88447480
163Hepatocellular necrosis (HP:0001404)1.88210371
164Inappropriate behavior (HP:0000719)1.85835692
165Bilateral sensorineural hearing impairment (HP:0008619)1.85400972
166Colitis (HP:0002583)1.84972018
1673-Methylglutaconic aciduria (HP:0003535)1.83885926
168Median cleft lip (HP:0000161)1.83728640
169Porencephaly (HP:0002132)1.83597285
170Abnormality of the astrocytes (HP:0100707)1.82874569
171Gait imbalance (HP:0002141)1.82231721
172Congenital hepatic fibrosis (HP:0002612)1.81026302
173Mutism (HP:0002300)1.80452962
174Hypogonadotrophic hypogonadism (HP:0000044)1.78355181
175Sclerocornea (HP:0000647)1.76268990
176Abnormality of the corticospinal tract (HP:0002492)1.75727493
177Disinhibition (HP:0000734)1.75535900
178Congenital stationary night blindness (HP:0007642)1.75493879
179Narrow forehead (HP:0000341)1.75487148
180Abnormality of lateral ventricle (HP:0030047)1.72020393
181X-linked dominant inheritance (HP:0001423)1.69979087
182Horseshoe kidney (HP:0000085)1.69172947
183Progressive microcephaly (HP:0000253)1.69096107
184Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.68649126
185Broad-based gait (HP:0002136)1.68311887
186Respiratory failure (HP:0002878)1.67719175
187Growth hormone deficiency (HP:0000824)1.67554952
188Retinal atrophy (HP:0001105)1.67357171
189Drooling (HP:0002307)1.65939586
190Abnormality of urine glucose concentration (HP:0011016)1.65684102
191Glycosuria (HP:0003076)1.65684102
192Oculomotor apraxia (HP:0000657)1.64795820
193Anophthalmia (HP:0000528)1.64740392
194Abnormality of the renal collecting system (HP:0004742)1.64322118
195Prominent nasal bridge (HP:0000426)1.64249962

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK7.05036941
2ICK6.22463696
3MAPK155.28918753
4DDR25.19426993
5MAP3K64.63013738
6STK164.17897764
7MAP3K113.42310183
8PINK13.28343297
9FGR3.24630764
10TYRO33.14915637
11CDK193.11507427
12MATK3.06351866
13PNCK2.84290258
14BMX2.47709250
15DAPK12.46714745
16NUAK12.46403752
17UHMK12.43386362
18PRKD22.39341964
19TNIK2.37196027
20CSK2.33634227
21PLK42.31579447
22ACVR1B2.18519574
23EPHB22.15007422
24YES12.13006241
25PIM22.08466127
26PDGFRA2.07777652
27TTK2.07756484
28DYRK1B2.00940667
29CDC71.93598615
30NTRK31.93232097
31LATS11.80637304
32CASK1.80086590
33TRPM71.79984650
34TAOK31.66538261
35CDK71.57849340
36ADRBK21.56761980
37WEE11.54761123
38MARK11.36743343
39PIM11.36028426
40CDK61.35287828
41AKT31.30141282
42MINK11.30043369
43CDC42BPA1.25603405
44RPS6KC11.24791177
45RPS6KL11.24791177
46MAP2K71.24618189
47PKN11.23374706
48MAP3K41.22638091
49PHKG21.22363164
50PHKG11.22363164
51ABL21.17860106
52LATS21.16419350
53PRKCG1.14879217
54GSK3A1.14350952
55TAF11.10926068
56PRPF4B1.09646961
57RPS6KA61.08420459
58WNK31.08096596
59VRK21.07314587
60PLK21.06435746
61NME21.06421607
62MAPK111.04415542
63MAPK131.01663460
64EPHA40.93960707
65CSNK1G20.90258978
66PBK0.88843995
67MAP3K100.87656307
68TLK10.86049392
69HIPK20.82047661
70CAMKK20.81178588
71CHEK20.80879188
72CAMK10.79542482
73CCNB10.78784955
74WNK40.70538356
75TAOK20.70473983
76MTOR0.68995140
77DYRK30.68987303
78BRAF0.68634750
79PRKAA10.68131104
80PLK30.67447149
81CDK120.65520538
82RPS6KA10.64327026
83INSRR0.63207831
84PLK10.61683442
85CLK10.58017285
86ERBB30.56840290
87CSNK1E0.56474792
88GRK70.56369267
89VRK10.55013880
90EIF2AK20.54291540
91CSNK1G30.54245986
92GRK10.53797551
93ERBB20.53122003
94EGFR0.51466507
95ADRBK10.51440458
96PRKCQ0.50258420
97PDGFRB0.48399447
98TIE10.47873233
99CSNK1A1L0.47395257
100STK390.45902252
101CAMK1G0.45753872
102LYN0.45360140
103RAF10.45249603
104MKNK20.44837683
105CAMK2B0.44546901
106BMPR1B0.44176070
107TNK20.43438418
108WNK10.42542366
109CAMK2G0.42351728
110SGK2230.41183372
111SGK4940.41183372
112OXSR10.40577643
113RPS6KB10.39386988
114ATR0.39220797
115PRKAA20.38530185
116CSNK1G10.38273011
117STK38L0.37352693
118MAPK30.37220633
119CDK20.37214786
120PRKACA0.37040476
121MAPK10.36947421
122MAPK40.36660229
123STK110.35808304
124TRIB30.35762354
125PAK30.35682521
126CSNK2A10.35169307
127NME10.34649521
128CSNK1A10.34491803
129PRKG10.34470421
130STK100.33282609
131RPS6KB20.32342411
132PRKCE0.32275120
133MAPK100.32131924
134MAP2K40.30743634
135INSR0.30721799
136STK240.30463078
137EPHA20.29614021
138MAPK120.29247664
139PRKCZ0.29163215
140CAMK2D0.28498871
141RIPK10.27953610
142MAPK140.27384058
143GSK3B0.27340961
144DYRK20.27254377
145SGK10.26194996
146CAMK2A0.25222595
147PRKD10.24944503
148MAPKAPK20.24740946
149MAP4K10.23458173
150AURKA0.23212031
151SIK20.22989970
152PTK20.22322668
153FGFR10.22228081
154CDK80.21877078
155CSNK2A20.21525687
156LCK0.20689654
157SIK10.20519509
158PAK20.20300178
159ALK0.19959625
160ATM0.19795377
161STK30.18505412
162TAOK10.18339321
163PRKCD0.17525580
164RPS6KA30.17473536
165MAP3K90.17052252
166CDK10.16810616
167MARK20.16313824
168PAK60.15836554
169DMPK0.15633174
170CDK11A0.15589232
171CHEK10.14534867
172CDK150.14125724
173STK380.13813872

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000616.60423247
2Oxidative phosphorylation_Homo sapiens_hsa001904.72818617
3Base excision repair_Homo sapiens_hsa034104.60458726
4Mismatch repair_Homo sapiens_hsa034304.54296719
5Parkinsons disease_Homo sapiens_hsa050123.99306396
6Huntingtons disease_Homo sapiens_hsa050163.12444001
7Cardiac muscle contraction_Homo sapiens_hsa042603.07234527
8DNA replication_Homo sapiens_hsa030303.04782371
9Alzheimers disease_Homo sapiens_hsa050102.93500903
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.82846297
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.74520139
12Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.71848621
13Asthma_Homo sapiens_hsa053102.62719057
14Notch signaling pathway_Homo sapiens_hsa043302.37148359
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.36613313
16Circadian rhythm_Homo sapiens_hsa047102.24968037
17Hedgehog signaling pathway_Homo sapiens_hsa043402.23700059
18mTOR signaling pathway_Homo sapiens_hsa041502.19994537
19Arginine and proline metabolism_Homo sapiens_hsa003302.19144723
20Hippo signaling pathway_Homo sapiens_hsa043902.04687930
21Sulfur relay system_Homo sapiens_hsa041221.91046952
22Nucleotide excision repair_Homo sapiens_hsa034201.84812682
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.82273527
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.81258837
25mRNA surveillance pathway_Homo sapiens_hsa030151.81248011
26Adherens junction_Homo sapiens_hsa045201.77943772
27Fatty acid metabolism_Homo sapiens_hsa012121.77519105
28Protein export_Homo sapiens_hsa030601.72233809
29Phototransduction_Homo sapiens_hsa047441.62570779
30RNA polymerase_Homo sapiens_hsa030201.55193954
31Nicotine addiction_Homo sapiens_hsa050331.54354771
32Regulation of autophagy_Homo sapiens_hsa041401.54337985
33Allograft rejection_Homo sapiens_hsa053301.54281992
34Spliceosome_Homo sapiens_hsa030401.54059894
35Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.54032491
36Biosynthesis of amino acids_Homo sapiens_hsa012301.52924095
37Longevity regulating pathway - mammal_Homo sapiens_hsa042111.50911613
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.50580683
39Bladder cancer_Homo sapiens_hsa052191.47199889
40Basal transcription factors_Homo sapiens_hsa030221.44876008
41Proteasome_Homo sapiens_hsa030501.44166324
42Transcriptional misregulation in cancer_Homo sapiens_hsa052021.43498791
43Olfactory transduction_Homo sapiens_hsa047401.43487808
44Lysine degradation_Homo sapiens_hsa003101.42994526
45p53 signaling pathway_Homo sapiens_hsa041151.41478169
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.39037136
47TGF-beta signaling pathway_Homo sapiens_hsa043501.38774620
48RNA transport_Homo sapiens_hsa030131.38505626
49Rheumatoid arthritis_Homo sapiens_hsa053231.37124311
50Basal cell carcinoma_Homo sapiens_hsa052171.36477234
51Fanconi anemia pathway_Homo sapiens_hsa034601.34900879
52Graft-versus-host disease_Homo sapiens_hsa053321.34799889
53Autoimmune thyroid disease_Homo sapiens_hsa053201.33858776
54Wnt signaling pathway_Homo sapiens_hsa043101.31008629
55Homologous recombination_Homo sapiens_hsa034401.26753792
56Primary immunodeficiency_Homo sapiens_hsa053401.24372955
57Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.21677637
58Pyrimidine metabolism_Homo sapiens_hsa002401.20695472
59Pentose and glucuronate interconversions_Homo sapiens_hsa000401.20296306
60Shigellosis_Homo sapiens_hsa051311.16579417
61Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.15093066
62Arginine biosynthesis_Homo sapiens_hsa002201.12351151
63Folate biosynthesis_Homo sapiens_hsa007901.10870008
64VEGF signaling pathway_Homo sapiens_hsa043701.09694933
65Dorso-ventral axis formation_Homo sapiens_hsa043201.03728109
66Maturity onset diabetes of the young_Homo sapiens_hsa049501.03698937
67Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.00590714
68Type I diabetes mellitus_Homo sapiens_hsa049400.99646749
69Fructose and mannose metabolism_Homo sapiens_hsa000510.92985871
70Regulation of actin cytoskeleton_Homo sapiens_hsa048100.89162635
71Steroid biosynthesis_Homo sapiens_hsa001000.87677381
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.85054707
73Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.84315966
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.83112315
75Synaptic vesicle cycle_Homo sapiens_hsa047210.82594810
76Staphylococcus aureus infection_Homo sapiens_hsa051500.82413152
77Cell cycle_Homo sapiens_hsa041100.82218468
78Colorectal cancer_Homo sapiens_hsa052100.81203401
79Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79477853
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.78850921
81Glycosaminoglycan degradation_Homo sapiens_hsa005310.77214911
82Axon guidance_Homo sapiens_hsa043600.77108896
83MicroRNAs in cancer_Homo sapiens_hsa052060.75745856
84Choline metabolism in cancer_Homo sapiens_hsa052310.75098492
85Purine metabolism_Homo sapiens_hsa002300.74709172
86Oocyte meiosis_Homo sapiens_hsa041140.73381492
87Glutamatergic synapse_Homo sapiens_hsa047240.71875553
88Linoleic acid metabolism_Homo sapiens_hsa005910.71791293
89Tight junction_Homo sapiens_hsa045300.70648080
90ErbB signaling pathway_Homo sapiens_hsa040120.69524552
91Morphine addiction_Homo sapiens_hsa050320.67924301
92Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.67421016
93Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.67415122
94Collecting duct acid secretion_Homo sapiens_hsa049660.67298101
95Acute myeloid leukemia_Homo sapiens_hsa052210.65592900
96Butanoate metabolism_Homo sapiens_hsa006500.65082328
97Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.63643240
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.62959998
99AMPK signaling pathway_Homo sapiens_hsa041520.62890399
100Viral myocarditis_Homo sapiens_hsa054160.61957693
101Gap junction_Homo sapiens_hsa045400.60535911
102RNA degradation_Homo sapiens_hsa030180.59235224
103Chronic myeloid leukemia_Homo sapiens_hsa052200.58736620
104Insulin signaling pathway_Homo sapiens_hsa049100.57364937
105Ether lipid metabolism_Homo sapiens_hsa005650.56718452
106Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.56636447
107Small cell lung cancer_Homo sapiens_hsa052220.55950645
108Taste transduction_Homo sapiens_hsa047420.53160199
109Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.50515310
110Glycerolipid metabolism_Homo sapiens_hsa005610.48456593
111Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46745764
112Metabolic pathways_Homo sapiens_hsa011000.45746454
113Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45281244
114Proteoglycans in cancer_Homo sapiens_hsa052050.43451349
115Legionellosis_Homo sapiens_hsa051340.41743791
116Galactose metabolism_Homo sapiens_hsa000520.41306406
117Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.40278780
118MAPK signaling pathway_Homo sapiens_hsa040100.40188936
119Glutathione metabolism_Homo sapiens_hsa004800.38178846
120Epstein-Barr virus infection_Homo sapiens_hsa051690.37566887
121Chemical carcinogenesis_Homo sapiens_hsa052040.37551205
122Systemic lupus erythematosus_Homo sapiens_hsa053220.36425929
123Viral carcinogenesis_Homo sapiens_hsa052030.36390837
124Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35891186
125Caffeine metabolism_Homo sapiens_hsa002320.35547127
126PI3K-Akt signaling pathway_Homo sapiens_hsa041510.35018064
127Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.32357519
128Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.31541777
129Phagosome_Homo sapiens_hsa041450.30430656
130Thyroid cancer_Homo sapiens_hsa052160.30143896
131Central carbon metabolism in cancer_Homo sapiens_hsa052300.29370626
132Long-term depression_Homo sapiens_hsa047300.29233016
133Fatty acid elongation_Homo sapiens_hsa000620.29157065
134Hematopoietic cell lineage_Homo sapiens_hsa046400.28970269
135Tryptophan metabolism_Homo sapiens_hsa003800.27785181
136Focal adhesion_Homo sapiens_hsa045100.27763035
137B cell receptor signaling pathway_Homo sapiens_hsa046620.27235564
138Steroid hormone biosynthesis_Homo sapiens_hsa001400.26400155
139Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26304047
140NOD-like receptor signaling pathway_Homo sapiens_hsa046210.25931414
141Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.25648050
142Serotonergic synapse_Homo sapiens_hsa047260.25158345
143Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.24859770
144Dopaminergic synapse_Homo sapiens_hsa047280.24845622
145Mineral absorption_Homo sapiens_hsa049780.23584832
146Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.23249434
147Pathways in cancer_Homo sapiens_hsa052000.22307892
148Endometrial cancer_Homo sapiens_hsa052130.21931685
149Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.21828032
150Leishmaniasis_Homo sapiens_hsa051400.21051480
151Endocytosis_Homo sapiens_hsa041440.20848988
152Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.20799795
153GABAergic synapse_Homo sapiens_hsa047270.19768578
154Antigen processing and presentation_Homo sapiens_hsa046120.19498907
155HTLV-I infection_Homo sapiens_hsa051660.18640169
156Non-homologous end-joining_Homo sapiens_hsa034500.17785530
157Vitamin digestion and absorption_Homo sapiens_hsa049770.17750651
158RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.17720722
159Drug metabolism - other enzymes_Homo sapiens_hsa009830.17584634
160Toll-like receptor signaling pathway_Homo sapiens_hsa046200.17351847
161Prostate cancer_Homo sapiens_hsa052150.16767530
162Circadian entrainment_Homo sapiens_hsa047130.16652092
163Salmonella infection_Homo sapiens_hsa051320.15701564
164Hepatitis B_Homo sapiens_hsa051610.15614423
165Ribosome_Homo sapiens_hsa030100.12760270
166GnRH signaling pathway_Homo sapiens_hsa049120.12730050
167Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.11378422
168Herpes simplex infection_Homo sapiens_hsa051680.11254616
169Pancreatic cancer_Homo sapiens_hsa052120.11145239
170Rap1 signaling pathway_Homo sapiens_hsa040150.10688121
171Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.10680712
172One carbon pool by folate_Homo sapiens_hsa006700.09834577
173Estrogen signaling pathway_Homo sapiens_hsa049150.09152241
174ABC transporters_Homo sapiens_hsa020100.08887027
175Sphingolipid signaling pathway_Homo sapiens_hsa040710.08483770

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