NPC1L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins. This protein takes up free cholesterol into cells through vesicular endocytosis and plays a critical role in the absorption of intestinal cholesterol. It also has the ability to transport alpha-tocopherol (vitamin E). The drug ezetimibe targets this protein and inhibits the absorption of intestinal cholesterol and alpha-tocopherol. In addition, this protein may play a critical role in regulating lipid metabolism. Polymorphic variations in this gene are associated with plasma total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels and coronary heart disease (CHD) risk. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)8.74393147
2* intestinal cholesterol absorption (GO:0030299)8.25783105
3vitamin A metabolic process (GO:0006776)7.89271403
4L-phenylalanine catabolic process (GO:0006559)7.50786899
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.50786899
6adhesion of symbiont to host cell (GO:0044650)7.47337332
7virion attachment to host cell (GO:0019062)7.47337332
8regulation of fibrinolysis (GO:0051917)7.45202675
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.96906543
10L-phenylalanine metabolic process (GO:0006558)6.96906543
11negative regulation of fibrinolysis (GO:0051918)6.80130517
12peptidyl-glutamic acid carboxylation (GO:0017187)6.32225238
13protein carboxylation (GO:0018214)6.32225238
14actin filament depolymerization (GO:0030042)6.29528718
15adhesion of symbiont to host (GO:0044406)6.11487485
16flavonoid metabolic process (GO:0009812)6.10141280
17triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.09227418
18exogenous drug catabolic process (GO:0042738)5.95619781
19phospholipid efflux (GO:0033700)5.92958577
20drug catabolic process (GO:0042737)5.92878220
21regulation of protein activation cascade (GO:2000257)5.90795004
22modified amino acid transport (GO:0072337)5.89118085
23regulation of cholesterol esterification (GO:0010872)5.73749103
24regulation of bile acid biosynthetic process (GO:0070857)5.72035940
25plasma lipoprotein particle assembly (GO:0034377)5.70572393
26positive regulation of lipoprotein lipase activity (GO:0051006)5.68500429
27positive regulation of triglyceride lipase activity (GO:0061365)5.68500429
28regulation of complement activation (GO:0030449)5.62669693
29protein-lipid complex assembly (GO:0065005)5.44081584
30regulation of triglyceride catabolic process (GO:0010896)5.41381717
31aromatic amino acid family catabolic process (GO:0009074)5.40520608
32peptide hormone processing (GO:0016486)5.26521112
33cholesterol efflux (GO:0033344)5.23703951
34glyoxylate metabolic process (GO:0046487)5.21412821
35glucose 6-phosphate metabolic process (GO:0051156)5.14983851
36drinking behavior (GO:0042756)5.09958293
37hormone catabolic process (GO:0042447)5.09870691
38very-low-density lipoprotein particle assembly (GO:0034379)5.09774116
39* digestive system process (GO:0022600)4.94021377
40digestion (GO:0007586)4.92901064
41lipoprotein transport (GO:0042953)4.91498048
42blood coagulation, intrinsic pathway (GO:0007597)4.88762451
433-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.88164086
44purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.88164086
45regulation of plasminogen activation (GO:0010755)4.83769085
46complement activation, alternative pathway (GO:0006957)4.82519585
47response to hepatocyte growth factor (GO:0035728)4.78675211
48cellular response to hepatocyte growth factor stimulus (GO:0035729)4.78675211
49omega-hydroxylase P450 pathway (GO:0097267)4.70357719
50diacylglycerol metabolic process (GO:0046339)4.56778738
51cellular glucuronidation (GO:0052695)4.56608579
52ethanol oxidation (GO:0006069)4.55144941
53peptide catabolic process (GO:0043171)4.51611721
54fibrinolysis (GO:0042730)4.50304077
55triglyceride homeostasis (GO:0070328)4.48249120
56acylglycerol homeostasis (GO:0055090)4.48249120
57cholesterol homeostasis (GO:0042632)4.41797483
58sterol homeostasis (GO:0055092)4.36516118
59glucuronate metabolic process (GO:0019585)4.36382118
60uronic acid metabolic process (GO:0006063)4.36382118
61negative regulation of sterol transport (GO:0032372)4.34365981
62negative regulation of cholesterol transport (GO:0032375)4.34365981
63purine nucleotide salvage (GO:0032261)4.28616945
64bundle of His cell to Purkinje myocyte communication (GO:0086069)4.25269790
65sulfate transmembrane transport (GO:1902358)4.25160673
66plasma lipoprotein particle clearance (GO:0034381)4.23938495
67negative regulation of protein activation cascade (GO:2000258)4.19200164
68oligosaccharide catabolic process (GO:0009313)4.17402037
69positive regulation of fatty acid biosynthetic process (GO:0045723)4.08279813
70reverse cholesterol transport (GO:0043691)4.07672900
71* lipoprotein metabolic process (GO:0042157)4.07188665
72low-density lipoprotein particle remodeling (GO:0034374)4.06292391
73sulfur compound transport (GO:0072348)4.04242224
74bile acid biosynthetic process (GO:0006699)3.94369688
75regulation of systemic arterial blood pressure by hormone (GO:0001990)3.90380979
76regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.90380979
77endocrine process (GO:0050886)3.90380979
78bile acid metabolic process (GO:0008206)3.86271500
79bile acid and bile salt transport (GO:0015721)3.83563155
80UDP-N-acetylglucosamine metabolic process (GO:0006047)3.80149435
81phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.80129312
82NADH metabolic process (GO:0006734)3.79656303
83sphingomyelin metabolic process (GO:0006684)3.79003179
84negative regulation of lipase activity (GO:0060192)3.75824782
85thyroid hormone metabolic process (GO:0042403)3.75282336
86negative regulation of digestive system process (GO:0060457)3.74712921
87glutamate metabolic process (GO:0006536)3.73499520
88negative regulation of blood coagulation (GO:0030195)3.68792195
89negative regulation of hemostasis (GO:1900047)3.68792195
90ethanol metabolic process (GO:0006067)3.68235509
91cellular ketone body metabolic process (GO:0046950)3.67197596
92aromatic amino acid family metabolic process (GO:0009072)3.63219342
93urea metabolic process (GO:0019627)3.63118146
94protein-lipid complex remodeling (GO:0034368)3.61331936
95macromolecular complex remodeling (GO:0034367)3.61331936
96plasma lipoprotein particle remodeling (GO:0034369)3.61331936
97serine family amino acid catabolic process (GO:0009071)3.61079730
98oxidative demethylation (GO:0070989)3.60836307
99peptidyl-glutamic acid modification (GO:0018200)3.59682021
100high-density lipoprotein particle remodeling (GO:0034375)3.58647100
101nucleobase catabolic process (GO:0046113)3.57380452
102amino-acid betaine metabolic process (GO:0006577)3.57053010
103S-adenosylmethionine metabolic process (GO:0046500)3.55742998
104acute-phase response (GO:0006953)3.55535627
105response to hydroperoxide (GO:0033194)3.55510272
106tyrosine metabolic process (GO:0006570)3.55129214
107positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.54909609
108plasma lipoprotein particle organization (GO:0071827)3.53766936
109regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.53631206
110indolalkylamine catabolic process (GO:0046218)3.53617239
111tryptophan catabolic process (GO:0006569)3.53617239
112indole-containing compound catabolic process (GO:0042436)3.53617239
113protein-lipid complex subunit organization (GO:0071825)3.52372625
114regulation of cholesterol homeostasis (GO:2000188)3.51577525
115sulfate transport (GO:0008272)3.48979351
116polyol transport (GO:0015791)3.48761056
117protein activation cascade (GO:0072376)3.46771305
118positive regulation of triglyceride metabolic process (GO:0090208)3.44982178
119maintenance of gastrointestinal epithelium (GO:0030277)3.44930718
120cellular carbohydrate catabolic process (GO:0044275)3.44853041
121imidazole-containing compound metabolic process (GO:0052803)3.44334253
122transepithelial transport (GO:0070633)3.44160256
123sulfation (GO:0051923)3.44127773
124regulation of digestive system process (GO:0044058)3.42634299
125regulation of systemic arterial blood pressure (GO:0003073)3.42544651
126positive regulation of T cell differentiation in thymus (GO:0033089)3.40067339
127negative regulation of coagulation (GO:0050819)3.39080437
128negative regulation of complement activation (GO:0045916)3.39055514
129intestinal epithelial cell development (GO:0060576)3.38238048
130negative regulation of wound healing (GO:0061045)3.33804708
131alpha-amino acid catabolic process (GO:1901606)3.29734526
132regulation of apoptotic cell clearance (GO:2000425)3.29391046
133heme transport (GO:0015886)3.28367365
134bicarbonate transport (GO:0015701)3.28077406
135* sterol transport (GO:0015918)3.24564806
136* cholesterol transport (GO:0030301)3.24564806
137nitrogen cycle metabolic process (GO:0071941)3.21803651
138regulation of lipoprotein metabolic process (GO:0050746)3.21384286
139neutral amino acid transport (GO:0015804)3.21303961
140ketone body metabolic process (GO:1902224)3.21236295
141fat-soluble vitamin biosynthetic process (GO:0042362)3.19495259
142regulation of humoral immune response (GO:0002920)3.18796122
143positive regulation of blood coagulation (GO:0030194)3.17657354
144positive regulation of hemostasis (GO:1900048)3.17657354
145drug transmembrane transport (GO:0006855)3.16713743
146regulation of actin nucleation (GO:0051125)3.16496351
147glycine metabolic process (GO:0006544)3.15785895
148epoxygenase P450 pathway (GO:0019373)3.10601439
149arginine metabolic process (GO:0006525)3.10382545
150protein kinase C signaling (GO:0070528)3.10234689
151coenzyme catabolic process (GO:0009109)3.08552609
152regulation of cholesterol transport (GO:0032374)3.07580773
153regulation of sterol transport (GO:0032371)3.07580773
154phenylpropanoid metabolic process (GO:0009698)3.06416716
155L-alpha-amino acid transmembrane transport (GO:1902475)3.05432102
156sperm capacitation (GO:0048240)3.05185129
157drug transport (GO:0015893)3.04131867
158glycerol metabolic process (GO:0006071)3.03398252
159drug metabolic process (GO:0017144)3.02607241
160positive regulation of lipid catabolic process (GO:0050996)3.01836974
161activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.01097472
162lipid homeostasis (GO:0055088)2.99828265
163transcytosis (GO:0045056)2.96416572
164negative regulation of sodium ion transport (GO:0010766)2.96402771
165angiotensin maturation (GO:0002003)13.5626354
166* intestinal absorption (GO:0050892)11.6861838

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.74087397
2CDX2_20551321_ChIP-Seq_CACO-2_Human5.73024762
3* SOX2_27498859_Chip-Seq_STOMACH_Mouse3.49069346
4HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.24801937
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.11286749
6GATA4_25053715_ChIP-Seq_YYC3_Human3.08581307
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.01075797
8PPARA_22158963_ChIP-Seq_LIVER_Mouse2.80582549
9GATA6_25053715_ChIP-Seq_YYC3_Human2.75216424
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.75038574
11LXR_22158963_ChIP-Seq_LIVER_Mouse2.63007530
12TRIM28_21343339_ChIP-Seq_HEK293_Human2.58147991
13SOX2_20726797_ChIP-Seq_SW620_Human2.44306965
14RXR_22158963_ChIP-Seq_LIVER_Mouse2.38936603
15TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.34898667
16PPAR_26484153_Chip-Seq_NCI-H1993_Human2.17109905
17CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.13653804
18CDX2_19796622_ChIP-Seq_MESCs_Mouse2.10453925
19SRY_22984422_ChIP-ChIP_TESTIS_Rat2.05925584
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.98087961
21NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.83619688
22KLF5_25053715_ChIP-Seq_YYC3_Human1.80081085
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.80051481
24ZNF274_21170338_ChIP-Seq_K562_Hela1.75690576
25TCF4_18268006_ChIP-ChIP_LS174T_Human1.73279964
26PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.71422174
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.70350720
28STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.68914502
29RUNX1_27514584_Chip-Seq_MCF-7_Human1.63968979
30CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.62922610
31EGR1_23403033_ChIP-Seq_LIVER_Mouse1.62397296
32NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.59360900
33ESR2_21235772_ChIP-Seq_MCF-7_Human1.58532586
34KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.56238401
35GATA2_19941826_ChIP-Seq_K562_Human1.53479601
36TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.53110965
37RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51207854
38KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.50071018
39HNF4A_19822575_ChIP-Seq_HepG2_Human1.49284485
40CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.47647050
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.46879661
42GBX2_23144817_ChIP-Seq_PC3_Human1.44080028
43NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.42252973
44HTT_18923047_ChIP-ChIP_STHdh_Human1.40662493
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.38498985
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.37911283
47SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.37275329
48ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.36058065
49BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.35461470
50FOXO3_23340844_ChIP-Seq_DLD1_Human1.33170757
51ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.33003575
52CLOCK_20551151_ChIP-Seq_293T_Human1.31826550
53GATA1_22025678_ChIP-Seq_K562_Human1.31163064
54HIF1A_21447827_ChIP-Seq_MCF-7_Human1.30921626
55* RACK7_27058665_Chip-Seq_MCF-7_Human1.29326135
56BCAT_22108803_ChIP-Seq_LS180_Human1.28594126
57ER_23166858_ChIP-Seq_MCF-7_Human1.27462309
58TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.27102531
59POU3F2_20337985_ChIP-ChIP_501MEL_Human1.26890940
60GATA1_26923725_Chip-Seq_HPCs_Mouse1.26531594
61* ATF3_27146783_Chip-Seq_COLON_Human1.26295391
62FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.24847361
63FOXA2_19822575_ChIP-Seq_HepG2_Human1.24703132
64NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.24432274
65NFE2_27457419_Chip-Seq_LIVER_Mouse1.24407970
66RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.23659909
67IGF1R_20145208_ChIP-Seq_DFB_Human1.23160706
68IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22629236
69CBP_20019798_ChIP-Seq_JUKART_Human1.22629236
70CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22264236
71ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.21500050
72PCGF2_27294783_Chip-Seq_NPCs_Mouse1.20938620
73CDX2_22108803_ChIP-Seq_LS180_Human1.20418980
74ETV2_25802403_ChIP-Seq_MESCs_Mouse1.19992245
75THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.17297112
76* MYC_19829295_ChIP-Seq_ESCs_Human1.16873315
77SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15303101
78CREB1_26743006_Chip-Seq_LNCaP_Human1.14565314
79TCF3_18692474_ChIP-Seq_MEFs_Mouse1.14022710
80EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13930667
81* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.12928663
82ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12630217
83ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12149567
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09565248
85SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.09282784
86PIAS1_25552417_ChIP-Seq_VCAP_Human1.08766301
87CTNNB1_20460455_ChIP-Seq_HCT116_Human1.08171109
88SALL4_18804426_ChIP-ChIP_XEN_Mouse1.08084676
89RAC3_21632823_ChIP-Seq_H3396_Human1.06623452
90FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.06172652
91AR_21909140_ChIP-Seq_LNCAP_Human1.05686091
92P300_19829295_ChIP-Seq_ESCs_Human1.05051333
93EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.05040274
94AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04131930
95PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.04122064
96STAT3_23295773_ChIP-Seq_U87_Human1.03632991
97FOXA1_25329375_ChIP-Seq_VCAP_Human1.03379134
98FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03379134
99ZFP57_27257070_Chip-Seq_ESCs_Mouse1.03070067
100SMAD3_21741376_ChIP-Seq_HESCs_Human1.02027804
101ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.01834230
102KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01790439
103TCF4_22108803_ChIP-Seq_LS180_Human1.01151274
104AR_20517297_ChIP-Seq_VCAP_Human1.00927977
105ZNF263_19887448_ChIP-Seq_K562_Human1.00751098
106* KAP1_22055183_ChIP-Seq_ESCs_Mouse1.00096488
107EZH2_27294783_Chip-Seq_NPCs_Mouse1.00091411
108NANOG_19829295_ChIP-Seq_ESCs_Human0.99947282
109SOX2_19829295_ChIP-Seq_ESCs_Human0.99947282
110AR_25329375_ChIP-Seq_VCAP_Human0.99184308
111AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.99132496
112CEBPB_22108803_ChIP-Seq_LS180_Human0.99022461
113EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.98684667
114ERA_21632823_ChIP-Seq_H3396_Human0.98276861
115SMAD4_21741376_ChIP-Seq_EPCs_Human0.98225551
116SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.97398869
117GATA1_19941826_ChIP-Seq_K562_Human0.94727382
118POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94544727
119TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94544727
120FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.94433634
121TAF15_26573619_Chip-Seq_HEK293_Human0.94299492
122* TAF2_19829295_ChIP-Seq_ESCs_Human0.93446733
123SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93446432
124ESR1_21235772_ChIP-Seq_MCF-7_Human0.93296650
125* GATA3_21878914_ChIP-Seq_MCF-7_Human0.93235329
126VDR_22108803_ChIP-Seq_LS180_Human0.93014221
127NCOR_22424771_ChIP-Seq_293T_Human0.92914365
128TCF4_23295773_ChIP-Seq_U87_Human0.92899560
129STAT3_18555785_Chip-Seq_ESCs_Mouse0.92514012
130EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.92403523
131CBP_21632823_ChIP-Seq_H3396_Human0.92232383
132TCF3_18692474_ChIP-Seq_MESCs_Mouse0.90879708
133OCT4_18555785_Chip-Seq_ESCs_Mouse0.90699963
134SMAD4_21799915_ChIP-Seq_A2780_Human0.89134205
135PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.88696638
136CTCF_27219007_Chip-Seq_Bcells_Human0.88645702
137EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.88569520
138OCT4_20526341_ChIP-Seq_ESCs_Human0.88405919
139KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.88357681
140* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88293566
141CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.88212895
142SUZ12_18555785_Chip-Seq_ESCs_Mouse0.88151027
143EGR1_19032775_ChIP-ChIP_M12_Human0.87654414
144FOXH1_21741376_ChIP-Seq_EPCs_Human0.87450844
145CTCF_18555785_Chip-Seq_ESCs_Mouse0.87031473
146LXR_22292898_ChIP-Seq_THP-1_Human0.86539134
147SMAD4_21741376_ChIP-Seq_HESCs_Human0.84953221
148STAT6_21828071_ChIP-Seq_BEAS2B_Human0.84668119
149NANOG_18555785_Chip-Seq_ESCs_Mouse0.84548554
150SMAD1_18555785_Chip-Seq_ESCs_Mouse0.84210645
151P300_27058665_Chip-Seq_ZR-75-30cells_Human0.84034729
152PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.83491600
153DROSHA_22980978_ChIP-Seq_HELA_Human0.83490497
154SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82949759
155GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82370735
156TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79731334
157NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.79183194
158TP63_23658742_ChIP-Seq_EP156T_Human0.78164411
159PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.77326697
160TP53_16413492_ChIP-PET_HCT116_Human0.76944564
161NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.76645271
162POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.76444224
163NANOG_20526341_ChIP-Seq_ESCs_Human0.76201860
164ESR1_20079471_ChIP-ChIP_T-47D_Human0.75568397
165JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.74136248
166* BCOR_27268052_Chip-Seq_Bcells_Human0.74026244
167TP63_22573176_ChIP-Seq_HFKS_Human0.73986140
168STAT1_17558387_ChIP-Seq_HELA_Human0.72493142
169FOXA1_25552417_ChIP-Seq_VCAP_Human0.71826955
170UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.70931314
171RARA_24833708_ChIP-Seq_LIVER_Mouse0.69582574
172SOX9_24532713_ChIP-Seq_HFSC_Mouse0.67846723

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0001666_abnormal_nutrient_absorption5.57353668
2MP0003195_calcinosis5.43016118
3MP0009840_abnormal_foam_cell4.56755566
4MP0003183_abnormal_peptide_metabolism4.56341716
5MP0002139_abnormal_hepatobiliary_system3.79476253
6MP0004264_abnormal_extraembryonic_tissu3.56372865
7MP0005085_abnormal_gallbladder_physiolo3.41783496
8MP0003252_abnormal_bile_duct3.33128046
9MP0010234_abnormal_vibrissa_follicle3.28188944
10MP0008875_abnormal_xenobiotic_pharmacok3.04380936
11MP0000462_abnormal_digestive_system2.84845221
12MP0003122_maternal_imprinting2.82369988
13MP0003866_abnormal_defecation2.54124982
14MP0002822_catalepsy2.34320053
15MP0004147_increased_porphyrin_level2.30899326
16* MP0010329_abnormal_lipoprotein_level2.27787061
17MP0005377_hearing/vestibular/ear_phenot2.19164688
18MP0003878_abnormal_ear_physiology2.19164688
19MP0002138_abnormal_hepatobiliary_system2.10806354
20MP0004019_abnormal_vitamin_homeostasis2.10299174
21MP0005360_urolithiasis10.9577652
22MP0005365_abnormal_bile_salt1.98478800
23MP0005410_abnormal_fertilization1.96649467
24MP0002909_abnormal_adrenal_gland1.85951023
25MP0005408_hypopigmentation1.85824334
26MP0000537_abnormal_urethra_morphology1.80650065
27MP0000538_abnormal_urinary_bladder1.72881287
28MP0004043_abnormal_pH_regulation1.71308613
29MP0009697_abnormal_copulation1.65647915
30MP0001664_abnormal_digestion1.59008017
31MP0005381_digestive/alimentary_phenotyp1.55060338
32MP0010352_gastrointestinal_tract_polyps1.52692229
33MP0001663_abnormal_digestive_system1.50336210
34MP0003705_abnormal_hypodermis_morpholog1.49872621
35MP0003172_abnormal_lysosome_physiology1.49246717
36MP0003011_delayed_dark_adaptation1.40275186
37MP0010155_abnormal_intestine_physiology1.38787775
38MP0000477_abnormal_intestine_morphology1.37170148
39MP0002254_reproductive_system_inflammat1.37060313
40MP0002089_abnormal_postnatal_growth/wei1.37016082
41MP0005379_endocrine/exocrine_gland_phen1.36202390
42MP0003191_abnormal_cellular_cholesterol1.34504250
43MP0001873_stomach_inflammation1.31390457
44MP0001944_abnormal_pancreas_morphology1.26056275
45MP0001661_extended_life_span1.23368023
46MP0002796_impaired_skin_barrier1.22469917
47MP0001756_abnormal_urination1.22205328
48MP0005670_abnormal_white_adipose1.20491301
49MP0005332_abnormal_amino_acid1.19056567
50MP0004270_analgesia1.19016143
51MP0003300_gastrointestinal_ulcer1.18343750
52MP0000490_abnormal_crypts_of1.17076722
53* MP0002078_abnormal_glucose_homeostasis1.15592425
54* MP0005448_abnormal_energy_balance1.14847126
55MP0009379_abnormal_foot_pigmentation1.11336837
56MP0002876_abnormal_thyroid_physiology1.07109254
57MP0009643_abnormal_urine_homeostasis1.06981522
58MP0005551_abnormal_eye_electrophysiolog1.06058894
59MP0003718_maternal_effect1.05486995
60MP0000639_abnormal_adrenal_gland1.05395613
61MP0000566_synostosis1.04661825
62MP0005451_abnormal_body_composition1.04555980
63MP0005220_abnormal_exocrine_pancreas1.04230220
64MP0006054_spinal_hemorrhage0.99280254
65MP0005646_abnormal_pituitary_gland0.98894582
66* MP0002118_abnormal_lipid_homeostasis0.95549022
67MP0003806_abnormal_nucleotide_metabolis0.95495763
68MP0003123_paternal_imprinting0.90948523
69MP0005167_abnormal_blood-brain_barrier0.90199662
70MP0001849_ear_inflammation0.89972272
71MP0002693_abnormal_pancreas_physiology0.89014369
72* MP0000609_abnormal_liver_physiology0.87363342
73MP0005367_renal/urinary_system_phenotyp0.85936555
74MP0000516_abnormal_urinary_system0.85936555
75MP0000598_abnormal_liver_morphology0.84963373
76MP0009046_muscle_twitch0.84845193
77MP0003953_abnormal_hormone_level0.84102328
78MP0005266_abnormal_metabolism0.84046229
79MP0004947_skin_inflammation0.83652312
80MP0003121_genomic_imprinting0.82187740
81MP0002837_dystrophic_cardiac_calcinosis0.82058103
82MP0003879_abnormal_hair_cell0.81246635
83MP0000467_abnormal_esophagus_morphology0.79495616
84MP0009384_cardiac_valve_regurgitation0.77755201
85MP0005083_abnormal_biliary_tract0.76648813
86MP0008872_abnormal_physiological_respon0.76436852
87MP0010368_abnormal_lymphatic_system0.76128763
88MP0009780_abnormal_chondrocyte_physiolo0.75882721
89MP0010678_abnormal_skin_adnexa0.75551255
90MP0005395_other_phenotype0.74998241
91MP0002132_abnormal_respiratory_system0.74836426
92MP0003698_abnormal_male_reproductive0.74111317
93MP0001529_abnormal_vocalization0.73502693
94MP0005501_abnormal_skin_physiology0.73464263
95MP0009053_abnormal_anal_canal0.72939569
96MP0004133_heterotaxia0.71820648
97MP0003633_abnormal_nervous_system0.71575365
98MP0006138_congestive_heart_failure0.69772653
99MP0001764_abnormal_homeostasis0.67542984
100MP0003283_abnormal_digestive_organ0.67191195
101MP0003656_abnormal_erythrocyte_physiolo0.66870419
102MP0003950_abnormal_plasma_membrane0.65802449
103* MP0005084_abnormal_gallbladder_morpholo0.65161088
104MP0002098_abnormal_vibrissa_morphology0.65032287
105MP0002938_white_spotting0.64170810
106MP0005319_abnormal_enzyme/_coenzyme0.63512138
107MP0001929_abnormal_gametogenesis0.62386316
108MP0010386_abnormal_urinary_bladder0.61777412
109MP0000013_abnormal_adipose_tissue0.61213881
110MP0005166_decreased_susceptibility_to0.60640480
111MP0005058_abnormal_lysosome_morphology0.59538526
112MP0001984_abnormal_olfaction0.59521147
113MP0005645_abnormal_hypothalamus_physiol0.59052132
114MP0002136_abnormal_kidney_physiology0.58014440
115MP0001765_abnormal_ion_homeostasis0.57173510
116MP0002928_abnormal_bile_duct0.55876844
117MP0005535_abnormal_body_temperature0.55683776
118MP0008469_abnormal_protein_level0.55604338
119MP0000678_abnormal_parathyroid_gland0.55234488
120MP0005376_homeostasis/metabolism_phenot0.54896209
121MP0002168_other_aberrant_phenotype0.54022535
122MP0003453_abnormal_keratinocyte_physiol0.53658956
123MP0001915_intracranial_hemorrhage0.53626782
124MP0009115_abnormal_fat_cell0.53586384
125MP0005636_abnormal_mineral_homeostasis0.52291537
126MP0000604_amyloidosis0.52155282
127MP0003315_abnormal_perineum_morphology0.51540209
128MP0002557_abnormal_social/conspecific_i0.51371415
129MP0003631_nervous_system_phenotype0.51200921
130MP0009765_abnormal_xenobiotic_induced0.51069752
131* MP0009642_abnormal_blood_homeostasis0.49877256
132MP0003638_abnormal_response/metabolism_0.49559961
133MP0005310_abnormal_salivary_gland0.49494743
134MP0002638_abnormal_pupillary_reflex0.49041617
135MP0001216_abnormal_epidermal_layer0.48001876
136MP0004142_abnormal_muscle_tone0.47277776
137MP0001485_abnormal_pinna_reflex0.46735725
138MP0000003_abnormal_adipose_tissue0.46206796
139MP0005584_abnormal_enzyme/coenzyme_acti0.46084330
140MP0000371_diluted_coat_color0.45124616
141MP0002161_abnormal_fertility/fecundity0.44824886
142MP0001881_abnormal_mammary_gland0.44224631
143MP0000427_abnormal_hair_cycle0.43700867
144MP0001191_abnormal_skin_condition0.43208995
145MP0000230_abnormal_systemic_arterial0.39935718
146MP0003119_abnormal_digestive_system0.38407871
147MP0003868_abnormal_feces_composition0.38205322
148MP0008873_increased_physiological_sensi0.36661976
149MP0003938_abnormal_ear_development0.35339332
150MP0002971_abnormal_brown_adipose0.35259201
151MP0003693_abnormal_embryo_hatching0.35182439
152MP0010307_abnormal_tumor_latency0.33612396
153MP0005334_abnormal_fat_pad0.32159944
154MP0000470_abnormal_stomach_morphology0.31805717
155MP0005023_abnormal_wound_healing0.31754676
156MP0005409_darkened_coat_color0.31525579

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)8.39951186
2Ileus (HP:0002595)8.20598972
3Abnormality of glutamine family amino acid metabolism (HP:0010902)7.96943340
4Acanthocytosis (HP:0001927)7.86164704
5Abnormality of aromatic amino acid family metabolism (HP:0004338)7.80991797
6Hypobetalipoproteinemia (HP:0003563)7.75971071
7Prolonged partial thromboplastin time (HP:0003645)7.71836377
8Autoimmune thrombocytopenia (HP:0001973)6.27320507
9Hydroxyprolinuria (HP:0003080)6.24352914
10Abnormality of proline metabolism (HP:0010907)6.24352914
11Malnutrition (HP:0004395)6.08997026
12Complement deficiency (HP:0004431)5.65049921
13Joint hemorrhage (HP:0005261)5.50854420
14Conjugated hyperbilirubinemia (HP:0002908)5.43216313
15Cupped ribs (HP:0000887)4.73591903
16Right ventricular cardiomyopathy (HP:0011663)4.72694751
17Poikilocytosis (HP:0004447)4.71916077
18Autoimmune hemolytic anemia (HP:0001890)4.68767238
19Pigmentary retinal degeneration (HP:0001146)4.47672112
20Fat malabsorption (HP:0002630)4.46013360
21Hypolipoproteinemia (HP:0010981)4.44155999
22Abnormality of the common coagulation pathway (HP:0010990)4.36595008
23Hyperglycinuria (HP:0003108)4.30940658
24Hyperlipoproteinemia (HP:0010980)4.19074525
25Abnormality of complement system (HP:0005339)4.11654479
26Chronic diarrhea (HP:0002028)4.10401425
27Widely patent fontanelles and sutures (HP:0004492)4.08948431
28Spontaneous abortion (HP:0005268)4.06827140
29Increased IgE level (HP:0003212)3.73288569
30Mesangial abnormality (HP:0001966)3.65186014
31Glomerulonephritis (HP:0000099)3.63456677
32Systemic lupus erythematosus (HP:0002725)3.62658629
33Facial shape deformation (HP:0011334)3.54169559
34Potter facies (HP:0002009)3.54169559
35Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.42533917
36Hypoglycemic coma (HP:0001325)3.38699443
37Vascular calcification (HP:0004934)3.34736018
38Abdominal distention (HP:0003270)3.32044636
39Abnormality of the vitamin B12 metabolism (HP:0004341)3.29584578
40Generalized aminoaciduria (HP:0002909)3.19829022
41B lymphocytopenia (HP:0010976)3.19782780
42Abnormality of B cell number (HP:0010975)3.19782780
43Glycosuria (HP:0003076)3.18607754
44Abnormality of urine glucose concentration (HP:0011016)3.18607754
45Hyperglycinemia (HP:0002154)3.16124974
46Xanthomatosis (HP:0000991)3.13129313
47Hypercholesterolemia (HP:0003124)3.10107909
48Reticulocytosis (HP:0001923)3.07145417
49Abnormality of vitamin B metabolism (HP:0004340)3.07032973
50Abnormal glucose tolerance (HP:0001952)3.05403022
51Severe combined immunodeficiency (HP:0004430)2.98689871
52Abnormality of serine family amino acid metabolism (HP:0010894)2.97073770
53Abnormality of glycine metabolism (HP:0010895)2.97073770
54Nephrolithiasis (HP:0000787)2.94629031
55Hypothermia (HP:0002045)2.90639970
56Increased mean platelet volume (HP:0011877)2.89880844
57Gastrointestinal dysmotility (HP:0002579)2.88872021
58Osteomalacia (HP:0002749)2.85915633
59Hypoalphalipoproteinemia (HP:0003233)2.85330406
60Cardiovascular calcification (HP:0011915)2.83834591
61Hypophosphatemic rickets (HP:0004912)2.82293300
62Rickets (HP:0002748)2.78912431
63Dehydration (HP:0001944)2.77839999
64Confusion (HP:0001289)2.77135829
65Abnormality of aspartate family amino acid metabolism (HP:0010899)2.72501719
66Mitral stenosis (HP:0001718)2.70782558
67Combined immunodeficiency (HP:0005387)2.65942975
68Thyroiditis (HP:0100646)2.63584858
69Polycythemia (HP:0001901)2.62851089
70Abnormality of the intrinsic pathway (HP:0010989)2.62250378
71Abnormality of purine metabolism (HP:0004352)2.61876295
72Abnormality of monocarboxylic acid metabolism (HP:0010996)2.61443062
73Wide cranial sutures (HP:0010537)2.58990381
74Abnormality of vitamin metabolism (HP:0100508)2.56853638
75Mildly elevated creatine phosphokinase (HP:0008180)2.56144362
76Abnormality of sulfur amino acid metabolism (HP:0004339)2.55499785
77Gingival bleeding (HP:0000225)2.53964572
78Abnormal platelet volume (HP:0011876)2.53503729
79Ketosis (HP:0001946)2.51744850
80Hypoglycemic seizures (HP:0002173)2.51651307
81Epidermoid cyst (HP:0200040)2.50632618
82Ketoacidosis (HP:0001993)2.47294603
83Megaloblastic anemia (HP:0001889)2.47127399
84Pancreatic islet-cell hyperplasia (HP:0004510)2.44947826
85Menorrhagia (HP:0000132)2.44505922
86Proximal tubulopathy (HP:0000114)2.43730093
87Delayed CNS myelination (HP:0002188)2.43200587
88Myopathic facies (HP:0002058)2.42316760
89Retinal atrophy (HP:0001105)2.39360027
90Enlarged kidneys (HP:0000105)2.39005868
91Steatorrhea (HP:0002570)2.37513068
92Arthropathy (HP:0003040)2.37320266
93Hyperglycemia (HP:0003074)2.36623426
94Progressive sensorineural hearing impairment (HP:0000408)2.35238666
95Pustule (HP:0200039)2.33506852
96Nephritis (HP:0000123)2.32211984
97Hemorrhage of the eye (HP:0011885)2.29404999
98Hyperphosphaturia (HP:0003109)2.28437794
99Hyperinsulinemic hypoglycemia (HP:0000825)2.24753015
100Intrahepatic cholestasis (HP:0001406)2.24527526
101Abnormality of the gastric mucosa (HP:0004295)2.24048456
102Late onset (HP:0003584)2.23630142
103Abnormality of small intestinal villus morphology (HP:0011472)2.23304896
104Villous atrophy (HP:0011473)2.23304896
105Syncope (HP:0001279)2.22892566
106Urinary glycosaminoglycan excretion (HP:0003541)2.15392045
107Mucopolysacchariduria (HP:0008155)2.15392045
108Flat acetabular roof (HP:0003180)2.14694058
109Metabolic acidosis (HP:0001942)2.12086821
110Abnormality of nucleobase metabolism (HP:0010932)2.10175678
111Abnormality of mucopolysaccharide metabolism (HP:0011020)2.08715499
112Abnormality of polysaccharide metabolism (HP:0011012)2.08715499
113Abnormality of glycosaminoglycan metabolism (HP:0004371)2.08715499
114Abnormality of methionine metabolism (HP:0010901)2.08022362
115Alopecia of scalp (HP:0002293)2.07496839
116Hypoproteinemia (HP:0003075)2.06187326
117Skin nodule (HP:0200036)2.05501742
118Goiter (HP:0000853)2.04059292
119Hyperammonemia (HP:0001987)2.02702235
120Abnormal biliary tract morphology (HP:0012440)2.02435717
121Broad alveolar ridges (HP:0000187)2.01502064
122Palpitations (HP:0001962)2.01148951
123Cheilitis (HP:0100825)2.01073005
124Progressive hearing impairment (HP:0001730)1.98926345
125Abnormal platelet function (HP:0011869)1.98724962
126Impaired platelet aggregation (HP:0003540)1.98724962
127Congenital sensorineural hearing impairment (HP:0008527)1.97896564
128Gout (HP:0001997)1.95819240
129Milia (HP:0001056)1.95775485
130Woolly hair (HP:0002224)1.93465798
131Abnormal urine phosphate concentration (HP:0012599)1.93165366
132Hepatocellular carcinoma (HP:0001402)1.92950671
133Abnormality of the 1st metacarpal (HP:0010009)1.91554252
134Hyperparathyroidism (HP:0000843)1.91296466
135Abnormality of eosinophils (HP:0001879)1.90325509
136Fair hair (HP:0002286)1.88130629
137Bundle branch block (HP:0011710)1.87248328
138Nausea (HP:0002018)1.86604664
139Vaginal fistula (HP:0004320)1.86602579
140Hepatoblastoma (HP:0002884)1.85807687
141Abnormality of the nasal septum (HP:0000419)1.85176768
142Abnormal gallbladder physiology (HP:0012438)1.84814790
143Cholecystitis (HP:0001082)1.84814790
144Thin bony cortex (HP:0002753)1.84554826
145Abnormality of serum amino acid levels (HP:0003112)1.82179421
146Abnormality of endocrine pancreas physiology (HP:0012093)1.81169801
147Abnormality of the pancreatic islet cells (HP:0006476)1.81169801
148Abnormal albumin level (HP:0012116)1.80827732
149Hypoalbuminemia (HP:0003073)1.80827732
150Pili torti (HP:0003777)1.80606552
151Polygenic inheritance (HP:0010982)1.78956429
152Purpura (HP:0000979)1.77696863
153Renal cortical cysts (HP:0000803)1.77475986
154Thrombophlebitis (HP:0004418)1.77468973
155Gingivitis (HP:0000230)1.74778711
156Eosinophilia (HP:0001880)1.73163899
157Symptomatic seizures (HP:0011145)1.70858080
158Hyperbilirubinemia (HP:0002904)1.70643305
159Joint swelling (HP:0001386)1.69586689
160Rectal prolapse (HP:0002035)1.69392965
161Fragile skin (HP:0001030)1.68322381
162Bifid scrotum (HP:0000048)1.67272272
163Abnormality of pyrimidine metabolism (HP:0004353)1.65342495
164Abnormality of the vitreous humor (HP:0004327)1.64024046
165Abnormality of reticulocytes (HP:0004312)1.62286979
166Azoospermia (HP:0000027)1.62191634
167Irritability (HP:0000737)1.61051940
168Abnormality of fatty-acid metabolism (HP:0004359)1.54493837

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.46229112
2MST45.99864879
3AKT34.57635305
4MST1R4.00843544
5NME13.86495098
6FGFR43.79075621
7FGFR33.77659946
8GRK63.75075942
9LMTK23.69039451
10WNK43.28497995
11MAP3K43.14645895
12PRKG23.10081463
13NTRK32.98451251
14EPHA22.87822831
15RIPK12.59990699
16MAP3K102.55082981
17MAP4K22.47896115
18FGFR22.46140729
19MAP2K22.17507100
20NUAK12.15174357
21PTK62.09679177
22MAP3K22.01235753
23DAPK22.00471640
24ERN11.90136040
25INSRR1.86315181
26PHKG21.84146664
27PHKG11.84146664
28PINK11.81123962
29EPHB21.67657997
30TESK21.62981733
31ADRBK21.59911398
32WNK31.59307701
33STK38L1.55204120
34STK101.47880236
35TAOK11.47523112
36FGFR11.46484581
37PLK41.43294816
38MET1.42370365
39BRSK21.41049993
40STK391.40031272
41PNCK1.33663116
42CAMKK21.31431610
43MAPKAPK31.28510893
44RIPK41.27624096
45PRKCG1.27517359
46CASK1.26963500
47DDR21.26578559
48PLK21.23424041
49TNK21.20689142
50PRKCI1.20126283
51WNK11.14471820
52TESK11.12874008
53STK381.04473881
54TRPM71.03002635
55BMX1.02889626
56PRKCE1.02220963
57PKN21.01360529
58KSR20.99718615
59CAMK1G0.98317083
60TTK0.97753955
61MATK0.97510588
62MAP3K80.96917321
63PTK20.93671285
64EPHB10.93067979
65LATS10.91783164
66SIK20.91255926
67ACVR1B0.88710419
68SGK4940.88102781
69SGK2230.88102781
70MAP3K70.87973745
71MAP3K110.82774172
72MAP3K90.82632917
73PRKAA20.81491194
74FER0.79936923
75NLK0.77688336
76ERBB20.76165638
77MAP2K60.76014885
78TAOK30.75842131
79MYLK0.75094660
80PIK3CA0.73461746
81PRKG10.71851612
82SGK20.69800999
83ZAK0.67223918
84PAK40.65733071
85MAP3K10.60976061
86OXSR10.60360064
87BMPR1B0.60244403
88PRKACA0.60213555
89MAPK110.59737337
90SGK10.59435307
91ICK0.59046436
92MAP2K10.58961065
93CSNK1D0.58215843
94CSNK1E0.54888586
95FLT30.54888049
96PDPK10.53654156
97MAPK130.53652000
98CAMK1D0.52182579
99CSNK1G10.51997500
100TBK10.51118129
101MAP3K30.48173474
102PIM20.48107973
103SCYL20.46777883
104MAP2K40.46486848
105EPHA30.45704635
106PRKAA10.44678503
107PIK3CG0.42477429
108EEF2K0.42423361
109PBK0.42297177
110DMPK0.42223158
111BRD40.42038256
112STK30.40554397
113SGK30.40456605
114PAK30.39996847
115PDK20.39890152
116RET0.39457957
117PRKACB0.39307231
118MAPK150.39130060
119IGF1R0.37863129
120EPHA40.37269181
121GRK10.36897634
122RPS6KB10.36825092
123TNIK0.36095348
124MAP2K70.35095907
125IRAK30.35004575
126CDK120.34811859
127PRKCB0.34399696
128LRRK20.34066446
129BRSK10.33954075
130NEK90.33677229
131CHUK0.33621754
132DYRK1B0.32922074
133PDK10.31546529
134FGR0.31162917
135ERBB40.30547622
136PRKCA0.30311754
137AKT20.30133194
138LIMK10.27564225
139CSNK1A10.27492007
140PAK10.27427777
141MAP4K10.26544120
142AURKB0.26408770
143CSK0.26119900
144SRC0.24865135
145TYK20.24745647
146TYRO30.23544302
147MAPKAPK20.23398306
148ARAF0.23095233
149PRKACG0.22174586
150CAMK2D0.21409351
151MAP3K120.21395498
152BRAF0.21053458
153STK110.20922549
154PRKCQ0.20279778
155PRKCD0.20167181
156PAK20.18275798
157STK240.16737875
158FYN0.16656024
159CDK60.15895548
160CDK50.15430958
161MELK0.12331736
162CAMK2G0.12140718
163PRKCZ0.11343853
164ROCK10.09751971
165PDGFRA0.09285288
166ITK0.08774055
167CAMK2B0.07351730

Predicted pathways (KEGG)

RankGene SetZ-score
1* Fat digestion and absorption_Homo sapiens_hsa049755.66314259
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005245.34697059
3Renin-angiotensin system_Homo sapiens_hsa046145.23801153
4Vitamin digestion and absorption_Homo sapiens_hsa049774.51463183
5Mineral absorption_Homo sapiens_hsa049784.26294051
6Complement and coagulation cascades_Homo sapiens_hsa046103.54691299
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.44737993
8Caffeine metabolism_Homo sapiens_hsa002323.24159575
9Galactose metabolism_Homo sapiens_hsa000523.14762684
10Primary bile acid biosynthesis_Homo sapiens_hsa001203.13217813
11Carbohydrate digestion and absorption_Homo sapiens_hsa049733.00451393
12Starch and sucrose metabolism_Homo sapiens_hsa005002.81564433
13Protein digestion and absorption_Homo sapiens_hsa049742.57274462
14Folate biosynthesis_Homo sapiens_hsa007902.30055447
15Bile secretion_Homo sapiens_hsa049762.21295655
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.05297394
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.99996630
18Phenylalanine metabolism_Homo sapiens_hsa003601.96232967
19Fructose and mannose metabolism_Homo sapiens_hsa000511.88574965
20Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.83043415
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.80562994
22Sulfur metabolism_Homo sapiens_hsa009201.76960700
23Tyrosine metabolism_Homo sapiens_hsa003501.70849114
24Vitamin B6 metabolism_Homo sapiens_hsa007501.65472156
25Histidine metabolism_Homo sapiens_hsa003401.63733805
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.54771431
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.48560878
28Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.45889305
29PPAR signaling pathway_Homo sapiens_hsa033201.43065417
30Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.38741649
31Propanoate metabolism_Homo sapiens_hsa006401.38211573
32Glycerolipid metabolism_Homo sapiens_hsa005611.38203633
33Sphingolipid metabolism_Homo sapiens_hsa006001.36210959
34Glutathione metabolism_Homo sapiens_hsa004801.35863995
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.30864159
36Cyanoamino acid metabolism_Homo sapiens_hsa004601.29668821
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.25103699
38Tryptophan metabolism_Homo sapiens_hsa003801.08652479
39Arginine biosynthesis_Homo sapiens_hsa002201.08479892
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00885301
41Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.00632495
42Glycosaminoglycan degradation_Homo sapiens_hsa005310.96508913
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.95478954
44Arginine and proline metabolism_Homo sapiens_hsa003300.91869655
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.88301626
46One carbon pool by folate_Homo sapiens_hsa006700.87774090
47ABC transporters_Homo sapiens_hsa020100.86621305
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.85254244
49Glycerophospholipid metabolism_Homo sapiens_hsa005640.84913472
50Pentose and glucuronate interconversions_Homo sapiens_hsa000400.81154298
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.80231100
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.77518165
53Fatty acid degradation_Homo sapiens_hsa000710.77095965
54Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.77053236
55Drug metabolism - other enzymes_Homo sapiens_hsa009830.75360405
56Thyroid hormone synthesis_Homo sapiens_hsa049180.72615114
57Other glycan degradation_Homo sapiens_hsa005110.72049310
58Staphylococcus aureus infection_Homo sapiens_hsa051500.70453220
59Fatty acid elongation_Homo sapiens_hsa000620.68675027
60Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.66301031
61Nitrogen metabolism_Homo sapiens_hsa009100.62038266
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.60567049
63Tight junction_Homo sapiens_hsa045300.60269013
64Pentose phosphate pathway_Homo sapiens_hsa000300.58652290
65Type II diabetes mellitus_Homo sapiens_hsa049300.55446055
66Carbon metabolism_Homo sapiens_hsa012000.54764498
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53927792
68Protein export_Homo sapiens_hsa030600.50785620
69Pyruvate metabolism_Homo sapiens_hsa006200.49960457
70Retinol metabolism_Homo sapiens_hsa008300.44553210
71Glucagon signaling pathway_Homo sapiens_hsa049220.43467047
72beta-Alanine metabolism_Homo sapiens_hsa004100.42835173
73Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.42145105
74Chemical carcinogenesis_Homo sapiens_hsa052040.40223369
75Linoleic acid metabolism_Homo sapiens_hsa005910.39788546
76Sulfur relay system_Homo sapiens_hsa041220.39589864
77Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.38297260
78Pancreatic secretion_Homo sapiens_hsa049720.37843360
79Arachidonic acid metabolism_Homo sapiens_hsa005900.35249262
80Gastric acid secretion_Homo sapiens_hsa049710.30519851
81Fatty acid biosynthesis_Homo sapiens_hsa000610.30069205
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.29371307
83Circadian rhythm_Homo sapiens_hsa047100.27478739
84Prion diseases_Homo sapiens_hsa050200.26764764
85Biosynthesis of amino acids_Homo sapiens_hsa012300.26670991
86African trypanosomiasis_Homo sapiens_hsa051430.26595795
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.26369140
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.24426731
89Salmonella infection_Homo sapiens_hsa051320.24314532
90Collecting duct acid secretion_Homo sapiens_hsa049660.24140955
91Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.23630241
92Metabolic pathways_Homo sapiens_hsa011000.23348273
93Ether lipid metabolism_Homo sapiens_hsa005650.23310363
94N-Glycan biosynthesis_Homo sapiens_hsa005100.22971251
95Leukocyte transendothelial migration_Homo sapiens_hsa046700.22581554
96Bladder cancer_Homo sapiens_hsa052190.22027886
97Intestinal immune network for IgA production_Homo sapiens_hsa046720.20780790
98GnRH signaling pathway_Homo sapiens_hsa049120.20375570
99Thyroid cancer_Homo sapiens_hsa052160.20205200
100Hepatitis C_Homo sapiens_hsa051600.19224429
101Adherens junction_Homo sapiens_hsa045200.18779881
102Insulin secretion_Homo sapiens_hsa049110.18541672
103Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.18531905
104Peroxisome_Homo sapiens_hsa041460.16911643
105Renin secretion_Homo sapiens_hsa049240.16902671
106Steroid hormone biosynthesis_Homo sapiens_hsa001400.16710910
107Salivary secretion_Homo sapiens_hsa049700.15047121
108Fatty acid metabolism_Homo sapiens_hsa012120.13643660
109Lysine degradation_Homo sapiens_hsa003100.13565003
110Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.13167450
111Hematopoietic cell lineage_Homo sapiens_hsa046400.13076988
112Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.13018320
113Steroid biosynthesis_Homo sapiens_hsa001000.11959736
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.09565629
115Inositol phosphate metabolism_Homo sapiens_hsa005620.09498319
116Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.08411466
117Selenocompound metabolism_Homo sapiens_hsa004500.07251960
118Insulin resistance_Homo sapiens_hsa049310.06718920
119Choline metabolism in cancer_Homo sapiens_hsa052310.05579154
120Serotonergic synapse_Homo sapiens_hsa047260.05351438
121Oxidative phosphorylation_Homo sapiens_hsa001900.04903638
122Butanoate metabolism_Homo sapiens_hsa006500.04502864
123Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.03985683
124AMPK signaling pathway_Homo sapiens_hsa041520.03537176
125Ovarian steroidogenesis_Homo sapiens_hsa049130.03536121
126Long-term depression_Homo sapiens_hsa047300.03253228
127Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.03154741
128Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.02990124
129Gap junction_Homo sapiens_hsa045400.02763345
130Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.00288317
131VEGF signaling pathway_Homo sapiens_hsa043700.00088906
132Aldosterone synthesis and secretion_Homo sapiens_hsa04925-0.0551333
133Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280-0.0231115
134Purine metabolism_Homo sapiens_hsa00230-0.0139303
135Sphingolipid signaling pathway_Homo sapiens_hsa04071-0.0029092

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