NPAS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. A similar mouse protein may play a regulatory role in the acquisition of specific types of memory. It also may function as a part of a molecular clock operative in the mammalian forebrain. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)5.78765669
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.64886211
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.36090068
4synaptic vesicle docking involved in exocytosis (GO:0016081)5.29781656
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.19772173
6synaptic vesicle maturation (GO:0016188)4.97364507
7locomotory exploration behavior (GO:0035641)4.83960403
8regulation of glutamate receptor signaling pathway (GO:1900449)4.80757231
9glutamate secretion (GO:0014047)4.78091920
10synaptic vesicle exocytosis (GO:0016079)4.70776038
11neurotransmitter-gated ion channel clustering (GO:0072578)4.55542327
12regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.47324305
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.45353639
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.33960160
15protein localization to synapse (GO:0035418)4.26164183
16regulation of synaptic vesicle exocytosis (GO:2000300)4.25182534
17regulation of long-term neuronal synaptic plasticity (GO:0048169)4.16080025
18regulation of neuronal synaptic plasticity (GO:0048168)4.12988577
19regulation of synapse structural plasticity (GO:0051823)4.03626081
20synaptic transmission, glutamatergic (GO:0035249)4.03275379
21membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.00156548
22hemidesmosome assembly (GO:0031581)3.99134446
23desmosome organization (GO:0002934)3.96501696
24gamma-aminobutyric acid transport (GO:0015812)3.91650826
25regulation of excitatory postsynaptic membrane potential (GO:0060079)3.91202002
26glutamate receptor signaling pathway (GO:0007215)3.88519302
27positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.87387576
28neuron cell-cell adhesion (GO:0007158)3.83679623
29neuron-neuron synaptic transmission (GO:0007270)3.82063517
30regulation of synaptic vesicle transport (GO:1902803)3.80602413
31neuronal action potential propagation (GO:0019227)3.79840784
32neurotransmitter secretion (GO:0007269)3.76540895
33exploration behavior (GO:0035640)3.68869831
34regulation of postsynaptic membrane potential (GO:0060078)3.66560050
35auditory behavior (GO:0031223)3.66550124
36presynaptic membrane assembly (GO:0097105)3.62196260
37positive regulation of membrane potential (GO:0045838)3.60678396
38regulation of synaptic plasticity (GO:0048167)3.59986411
39long-term synaptic potentiation (GO:0060291)3.59654988
40striatum development (GO:0021756)3.55807966
41regulation of synaptic transmission, glutamatergic (GO:0051966)3.52505840
42postsynaptic membrane organization (GO:0001941)3.51592177
43skin morphogenesis (GO:0043589)3.49588283
44negative regulation of fibrinolysis (GO:0051918)3.46925722
45response to histamine (GO:0034776)3.46214146
46regulation of dendritic spine morphogenesis (GO:0061001)3.45834142
47regulation of female receptivity (GO:0045924)3.44156276
48response to auditory stimulus (GO:0010996)3.40930993
49dendritic spine morphogenesis (GO:0060997)3.40415369
50long-term memory (GO:0007616)3.40391770
51regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.38880678
52cellular potassium ion homeostasis (GO:0030007)3.34819972
53positive regulation of synapse maturation (GO:0090129)3.31853401
54positive regulation of neurotransmitter secretion (GO:0001956)3.31031224
55intestinal cholesterol absorption (GO:0030299)3.29569474
56regulation of plasminogen activation (GO:0010755)3.29417732
57prepulse inhibition (GO:0060134)3.26654718
58sodium ion export (GO:0071436)3.25911319
59lung epithelium development (GO:0060428)3.23838299
60G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.22091212
61presynaptic membrane organization (GO:0097090)3.21613662
62positive regulation of neurotransmitter transport (GO:0051590)3.19474005
63layer formation in cerebral cortex (GO:0021819)3.18317088
64proline transport (GO:0015824)3.18223784
65behavioral response to cocaine (GO:0048148)3.14065420
66endothelial cell chemotaxis (GO:0035767)3.12103873
67neuromuscular process controlling balance (GO:0050885)3.11980657
68regulation of fibrinolysis (GO:0051917)3.11377659
69female mating behavior (GO:0060180)3.10708161
70G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.09709569
71regulation of neurotransmitter secretion (GO:0046928)3.07848876
72membrane hyperpolarization (GO:0060081)3.06251496
73mechanosensory behavior (GO:0007638)3.05829030
74gamma-aminobutyric acid signaling pathway (GO:0007214)3.05402457
75behavioral defense response (GO:0002209)3.05260243
76behavioral fear response (GO:0001662)3.05260243
77regulation of glutamate secretion (GO:0014048)3.05005101
78positive regulation of synaptic transmission, GABAergic (GO:0032230)3.04906272
79learning (GO:0007612)3.01167458
80regulation of dendritic spine development (GO:0060998)2.99855142
81visual learning (GO:0008542)2.99199966
82neurotransmitter transport (GO:0006836)2.98623976
83positive regulation of synaptic transmission (GO:0050806)2.98124622
84L-amino acid import (GO:0043092)2.96903921
85membrane depolarization (GO:0051899)2.94938547
86adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.94886917
87regulation of voltage-gated calcium channel activity (GO:1901385)2.94099641
88synaptic vesicle endocytosis (GO:0048488)2.92663148
89long term synaptic depression (GO:0060292)2.92529788
90transmission of nerve impulse (GO:0019226)2.91390141
91regulation of neurotransmitter transport (GO:0051588)2.90927304
92negative regulation of fatty acid transport (GO:2000192)2.90617829
93negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.87048579
94response to amphetamine (GO:0001975)2.86487161
95negative regulation of dendrite development (GO:2000171)2.85597227
96synaptic transmission, dopaminergic (GO:0001963)2.83944520
97negative regulation of synaptic transmission, GABAergic (GO:0032229)2.83895305
98cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.83711027
99visual behavior (GO:0007632)2.83297260
100bundle of His cell to Purkinje myocyte communication (GO:0086069)2.83150852
101regulation of neurotransmitter levels (GO:0001505)2.82647558
102cell adhesion mediated by integrin (GO:0033627)2.82608822
103regulation of vesicle fusion (GO:0031338)2.82530522
104dendritic spine organization (GO:0097061)2.81518961
105regulation of cholesterol homeostasis (GO:2000188)2.81466473
106negative regulation of amino acid transport (GO:0051956)2.81088269
107protein carboxylation (GO:0018214)2.81085590
108peptidyl-glutamic acid carboxylation (GO:0017187)2.81085590
109chondrocyte proliferation (GO:0035988)2.80648787
110negative regulation of cytosolic calcium ion concentration (GO:0051481)2.78792675
111neuron recognition (GO:0008038)2.77587782
112actin filament depolymerization (GO:0030042)2.77012517
113fear response (GO:0042596)2.76910213
114regulation of synaptic transmission (GO:0050804)2.76532535
115activation of protein kinase A activity (GO:0034199)2.76024404
116dopamine receptor signaling pathway (GO:0007212)2.75815257
117regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.75181965
118membrane depolarization during action potential (GO:0086010)2.74858654
119lung vasculature development (GO:0060426)2.74772127
120regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.73957549
121nephron tubule morphogenesis (GO:0072078)2.69702005
122nephron epithelium morphogenesis (GO:0072088)2.69702005
123positive regulation of fatty acid beta-oxidation (GO:0032000)2.69449866
124cell-substrate junction assembly (GO:0007044)2.61261422
125mesodermal cell differentiation (GO:0048333)2.59668307
126endocardial cushion development (GO:0003197)2.55852581
127positive regulation of extracellular matrix organization (GO:1903055)2.52807689
128glomerular basement membrane development (GO:0032836)2.52042777
129basement membrane organization (GO:0071711)2.51548063
130intestinal absorption (GO:0050892)2.49586417
131response to gravity (GO:0009629)2.48824127
132embryonic retina morphogenesis in camera-type eye (GO:0060059)2.47913771
133positive regulation of fatty acid oxidation (GO:0046321)2.46692638
134cell-cell junction maintenance (GO:0045217)2.43065304
135negative regulation of catenin import into nucleus (GO:0035414)2.41030354
136regulation of protein activation cascade (GO:2000257)2.39958249
137regulation of complement activation (GO:0030449)2.39719809
138retina vasculature morphogenesis in camera-type eye (GO:0061299)2.32170588
139positive regulation of osteoblast proliferation (GO:0033690)2.31014865
140cell volume homeostasis (GO:0006884)2.30177723
141substrate-dependent cell migration (GO:0006929)2.29591218
142myelin maintenance (GO:0043217)2.29451194
143macroautophagy (GO:0016236)2.28663440
144phosphate ion transmembrane transport (GO:0035435)2.27732790
145regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.26998104
146keratinocyte proliferation (GO:0043616)2.26077028
147regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.24311422
148negative regulation of sodium ion transport (GO:0010766)2.21294942
149regulation of hippo signaling (GO:0035330)2.19549088
150negative regulation of protein activation cascade (GO:2000258)2.17752368
151cell junction maintenance (GO:0034331)2.17574866
152renal filtration (GO:0097205)2.17455222
153fibrinolysis (GO:0042730)2.16945699
154tonic smooth muscle contraction (GO:0014820)2.15384495
155cell communication involved in cardiac conduction (GO:0086065)2.15116235
156semaphorin-plexin signaling pathway (GO:0071526)2.13647215
157cytoskeletal anchoring at plasma membrane (GO:0007016)2.13143109
158cell proliferation involved in metanephros development (GO:0072203)2.12419720
159gap junction assembly (GO:0016264)2.11937697
160inositol phosphate-mediated signaling (GO:0048016)2.09610308
161cellular sodium ion homeostasis (GO:0006883)2.08756010
162erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.07875405
163L-phenylalanine metabolic process (GO:0006558)2.07875405
164endothelial cell morphogenesis (GO:0001886)2.07255332
165negative regulation of coagulation (GO:0050819)2.06999067
166regulation of the force of heart contraction (GO:0002026)2.06520182
167cell communication by electrical coupling (GO:0010644)2.06302523
168hypotonic response (GO:0006971)2.06031311
169embryonic foregut morphogenesis (GO:0048617)2.05877248
170negative regulation of blood coagulation (GO:0030195)2.05395548
171negative regulation of hemostasis (GO:1900047)2.05395548
172negative regulation of wound healing (GO:0061045)2.05135377
173regulation of axon extension involved in axon guidance (GO:0048841)2.05043672
174negative regulation of chondrocyte differentiation (GO:0032331)2.04132619
175negative regulation of complement activation (GO:0045916)2.03750257
176cell proliferation involved in kidney development (GO:0072111)2.03627504
177plasma membrane repair (GO:0001778)2.03616532
178renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.03501253
179lymphangiogenesis (GO:0001946)2.03363820
180regulation of extracellular matrix organization (GO:1903053)2.01979581
181peristalsis (GO:0030432)2.01623248
182negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.01438099
183regulation of bile acid biosynthetic process (GO:0070857)2.00605277
184regulation of fatty acid oxidation (GO:0046320)2.00459806
185negative regulation of hormone metabolic process (GO:0032351)1.98354798
186regulation of fatty acid beta-oxidation (GO:0031998)1.98069795
187positive regulation of astrocyte differentiation (GO:0048711)1.97905726
188very-low-density lipoprotein particle assembly (GO:0034379)1.97897668
189cell-substrate adherens junction assembly (GO:0007045)1.96427145
190focal adhesion assembly (GO:0048041)1.96427145
191regulation of extracellular matrix disassembly (GO:0010715)1.96421882
192regulation of type B pancreatic cell apoptotic process (GO:2000674)1.96029805
193positive regulation of sodium ion transmembrane transporter activity (GO:2000651)1.95739049
194epithelial cell-cell adhesion (GO:0090136)1.94685046
195neuron projection extension involved in neuron projection guidance (GO:1902284)1.94481687

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.58661763
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.25241365
3GBX2_23144817_ChIP-Seq_PC3_Human3.15153617
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.87442617
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.84712196
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.80288248
7* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.61221008
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.54079306
9* RARB_27405468_Chip-Seq_BRAIN_Mouse2.47828535
10DROSHA_22980978_ChIP-Seq_HELA_Human2.47684569
11* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.47119661
12* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.44598857
13* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.44598857
14* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.41576770
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.39106967
16NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.33086329
17* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.32386016
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.31234270
19* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.30829726
20* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.27540651
21ESR1_21235772_ChIP-Seq_MCF-7_Human2.21093895
22REST_21632747_ChIP-Seq_MESCs_Mouse2.16589927
23PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.16424511
24* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.07182382
25SMAD_19615063_ChIP-ChIP_OVARY_Human2.06199959
26* EZH2_27304074_Chip-Seq_ESCs_Mouse2.05683683
27* EZH2_27294783_Chip-Seq_ESCs_Mouse2.03467021
28* EED_16625203_ChIP-ChIP_MESCs_Mouse2.02127695
29* RNF2_27304074_Chip-Seq_ESCs_Mouse2.01460954
30AR_21572438_ChIP-Seq_LNCaP_Human1.90519026
31EP300_21415370_ChIP-Seq_HL-1_Mouse1.88401624
32IKZF1_21737484_ChIP-ChIP_HCT116_Human1.83986431
33CJUN_26792858_Chip-Seq_BT549_Human1.81545057
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.81025747
35FOXA2_19822575_ChIP-Seq_HepG2_Human1.80582987
36HIF1A_21447827_ChIP-Seq_MCF-7_Human1.76537559
37ZNF263_19887448_ChIP-Seq_K562_Human1.75780319
38CDX2_20551321_ChIP-Seq_CACO-2_Human1.74741847
39REST_18959480_ChIP-ChIP_MESCs_Mouse1.69347764
40ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.68900517
41SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.64023988
42* LXR_22158963_ChIP-Seq_LIVER_Mouse1.63649969
43* RXR_22158963_ChIP-Seq_LIVER_Mouse1.62472085
44* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.59778413
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58566501
46EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57342224
47GATA2_21666600_ChIP-Seq_HMVEC_Human1.55388261
48* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.55030125
49ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.51980209
50SMAD4_21799915_ChIP-Seq_A2780_Human1.51637151
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.51334161
52ERG_21242973_ChIP-ChIP_JURKAT_Human1.49873653
53* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.47144718
54TAF15_26573619_Chip-Seq_HEK293_Human1.42237270
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41435279
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40950449
57* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.39793145
58FOXO3_23340844_ChIP-Seq_DLD1_Human1.36905409
59TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.36757455
60SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.36301921
61GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.35770842
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.35081777
63JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.34990177
64TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.34597563
65TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.33802553
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30181612
67GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30042787
68SOX2_20726797_ChIP-Seq_SW620_Human1.29997566
69PIAS1_25552417_ChIP-Seq_VCAP_Human1.26429295
70* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.26404215
71P300_19829295_ChIP-Seq_ESCs_Human1.25815949
72CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25661946
73WT1_25993318_ChIP-Seq_PODOCYTE_Human1.24298250
74SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.23912104
75SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.23912104
76NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23626791
77SOX2_21211035_ChIP-Seq_LN229_Gbm1.23625023
78P53_22127205_ChIP-Seq_FIBROBLAST_Human1.22865239
79AR_25329375_ChIP-Seq_VCAP_Human1.22360485
80AHR_22903824_ChIP-Seq_MCF-7_Human1.21593923
81RXR_22108803_ChIP-Seq_LS180_Human1.20622273
82TP53_16413492_ChIP-PET_HCT116_Human1.20176425
83VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.20142835
84RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.19671007
85ZFP57_27257070_Chip-Seq_ESCs_Mouse1.19270128
86CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.19002798
87NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.18835429
88* RING1B_27294783_Chip-Seq_ESCs_Mouse1.18088053
89ARNT_22903824_ChIP-Seq_MCF-7_Human1.17827434
90JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17297036
91* STAT3_23295773_ChIP-Seq_U87_Human1.16423969
92* TP53_23651856_ChIP-Seq_MEFs_Mouse1.15896274
93GATA4_25053715_ChIP-Seq_YYC3_Human1.15211765
94SMAD3_21741376_ChIP-Seq_HESCs_Human1.14584740
95TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14397512
96STAT6_21828071_ChIP-Seq_BEAS2B_Human1.14171090
97* AR_19668381_ChIP-Seq_PC3_Human1.14009332
98RACK7_27058665_Chip-Seq_MCF-7_Human1.13969431
99DNAJC2_21179169_ChIP-ChIP_NT2_Human1.13920022
100FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.13315533
101KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.11810924
102TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11575822
103AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10722611
104P63_26484246_Chip-Seq_KERATINOCYTES_Human1.08029134
105* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.07728942
106* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.07075006
107* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.06796734
108* TBX20_22080862_ChIP-Seq_HEART_Mouse1.06120794
109* TBX20_22328084_ChIP-Seq_HEART_Mouse1.06120794
110TP53_22127205_ChIP-Seq_IMR90_Human1.05802863
111TP53_18474530_ChIP-ChIP_U2OS_Human1.05649425
112* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04954847
113* TCF4_18268006_ChIP-ChIP_LS174T_Human1.04854415
114LXR_22292898_ChIP-Seq_THP-1_Human1.04303923
115TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04049593
116* HNF4A_19822575_ChIP-Seq_HepG2_Human1.03601904
117SOX2_27498859_Chip-Seq_STOMACH_Mouse1.03541282
118* RING1B_27294783_Chip-Seq_NPCs_Mouse1.03424754
119TCF4_23295773_ChIP-Seq_U87_Human1.03314615
120KDM2B_26808549_Chip-Seq_K562_Human1.01882928
121* PRDM14_20953172_ChIP-Seq_ESCs_Human1.00809868
122EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.00467272
123POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00457212
124TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00457212
125RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99616485
126BCAT_22108803_ChIP-Seq_LS180_Human0.99515177
127BRD4_25478319_ChIP-Seq_HGPS_Human0.99243096
128NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98232665
129KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.98092159
130GATA6_25053715_ChIP-Seq_YYC3_Human0.97836671
131* PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.97670989
132RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.97573676
133FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97155142
134* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.96243152
135CTCF_27219007_Chip-Seq_Bcells_Human0.95944065
136THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.95853622
137SMAD4_21741376_ChIP-Seq_HESCs_Human0.95702118
138TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.95008311
139MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94108191
140* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.93698129
141ATF3_27146783_Chip-Seq_COLON_Human0.92556681
142YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92445805
143SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91834904
144* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91757534
145TET1_21490601_ChIP-Seq_MESCs_Mouse0.90789058
146TP63_22573176_ChIP-Seq_HFKS_Human0.90330160
147TRIM28_21343339_ChIP-Seq_HEK293_Human0.90098053
148OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89988818
149CTNNB1_20460455_ChIP-Seq_HCT116_Human0.89954036
150ESR1_20079471_ChIP-ChIP_T-47D_Human0.89757782
151CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.89750213
152SMAD3_21741376_ChIP-Seq_ESCs_Human0.89651180
153ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89464788
154BMI1_23680149_ChIP-Seq_NPCS_Mouse0.89454359
155BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.88175017
156ESR2_21235772_ChIP-Seq_MCF-7_Human0.86440054
157UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.86036200
158RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.85293643

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.64859087
2MP0002822_catalepsy4.60385717
3MP0003880_abnormal_central_pattern4.22178964
4MP0003635_abnormal_synaptic_transmissio3.97962130
5MP0004270_analgesia3.93468716
6MP0009745_abnormal_behavioral_response3.47880770
7* MP0002063_abnormal_learning/memory/cond3.38310195
8MP0010368_abnormal_lymphatic_system3.29957431
9MP0004272_abnormal_basement_membrane3.16409207
10MP0000566_synostosis3.16278843
11MP0008438_abnormal_cutaneous_collagen3.06133933
12MP0002064_seizures2.93915026
13MP0002572_abnormal_emotion/affect_behav2.76965193
14MP0009780_abnormal_chondrocyte_physiolo2.70669058
15MP0009046_muscle_twitch2.57057546
16MP0001968_abnormal_touch/_nociception2.56838297
17MP0005423_abnormal_somatic_nervous2.55687978
18MP0001486_abnormal_startle_reflex2.47047608
19MP0005360_urolithiasis2.43474508
20MP0002734_abnormal_mechanical_nocicepti2.32909893
21* MP0002272_abnormal_nervous_system2.29135668
22* MP0001501_abnormal_sleep_pattern2.29008141
23MP0003879_abnormal_hair_cell2.26476128
24MP0002254_reproductive_system_inflammat2.24597213
25MP0002909_abnormal_adrenal_gland2.15214407
26MP0005646_abnormal_pituitary_gland2.12156126
27MP0010234_abnormal_vibrissa_follicle2.07645560
28MP0005257_abnormal_intraocular_pressure2.04383582
29MP0001984_abnormal_olfaction1.93373093
30MP0002139_abnormal_hepatobiliary_system1.89362322
31MP0002736_abnormal_nociception_after1.88102669
32MP0005365_abnormal_bile_salt1.87791432
33MP0001440_abnormal_grooming_behavior1.85020534
34MP0003950_abnormal_plasma_membrane1.84697981
35MP0003566_abnormal_cell_adhesion1.84362491
36MP0008569_lethality_at_weaning1.81200491
37MP0002067_abnormal_sensory_capabilities1.68948930
38MP0005023_abnormal_wound_healing1.68732108
39MP0005670_abnormal_white_adipose1.67189427
40MP0002089_abnormal_postnatal_growth/wei1.67070775
41MP0004084_abnormal_cardiac_muscle1.66552640
42MP0000762_abnormal_tongue_morphology1.64814993
43MP0002876_abnormal_thyroid_physiology1.64358589
44MP0002557_abnormal_social/conspecific_i1.63552203
45MP0002733_abnormal_thermal_nociception1.62385024
46MP0001970_abnormal_pain_threshold1.61913361
47MP0001666_abnormal_nutrient_absorption1.60672903
48MP0004858_abnormal_nervous_system1.59374298
49MP0004924_abnormal_behavior1.59043621
50MP0005386_behavior/neurological_phenoty1.59043621
51MP0000003_abnormal_adipose_tissue1.56832740
52MP0002735_abnormal_chemical_nociception1.56753331
53MP0000579_abnormal_nail_morphology1.52568738
54MP0010030_abnormal_orbit_morphology1.51603957
55MP0003705_abnormal_hypodermis_morpholog1.49606923
56MP0003283_abnormal_digestive_organ1.49596218
57MP0003329_amyloid_beta_deposits1.48487251
58MP0005085_abnormal_gallbladder_physiolo1.45841287
59MP0009840_abnormal_foam_cell1.44281165
60MP0001502_abnormal_circadian_rhythm1.41209915
61MP0010329_abnormal_lipoprotein_level1.39856490
62MP0004885_abnormal_endolymph1.38907517
63MP0001879_abnormal_lymphatic_vessel1.38299740
64MP0003868_abnormal_feces_composition1.38037972
65MP0004811_abnormal_neuron_physiology1.37383190
66MP0000778_abnormal_nervous_system1.35089118
67MP0005275_abnormal_skin_tensile1.34845632
68MP0005503_abnormal_tendon_morphology1.34458303
69MP0009384_cardiac_valve_regurgitation1.32155620
70MP0005499_abnormal_olfactory_system1.31938520
71MP0005394_taste/olfaction_phenotype1.31938520
72MP0003633_abnormal_nervous_system1.31732718
73MP0003075_altered_response_to1.30154268
74MP0001299_abnormal_eye_distance/1.29600965
75MP0008872_abnormal_physiological_respon1.29506755
76MP0005623_abnormal_meninges_morphology1.27339808
77MP0001188_hyperpigmentation1.26739652
78MP0002184_abnormal_innervation1.25026558
79MP0001529_abnormal_vocalization1.24948831
80MP0003279_aneurysm1.23961904
81MP0002060_abnormal_skin_morphology1.22865936
82MP0000467_abnormal_esophagus_morphology1.19255982
83MP0002066_abnormal_motor_capabilities/c1.16801177
84MP0004510_myositis1.16545970
85MP0008874_decreased_physiological_sensi1.16385462
86MP0008961_abnormal_basal_metabolism1.15884036
87MP0006138_congestive_heart_failure1.15277897
88MP0002896_abnormal_bone_mineralization1.15012017
89MP0001958_emphysema1.12793094
90MP0003091_abnormal_cell_migration1.11192888
91MP0003195_calcinosis1.10555716
92MP0000534_abnormal_ureter_morphology1.10551851
93MP0005171_absent_coat_pigmentation1.10406448
94MP0001177_atelectasis1.09845340
95MP0003183_abnormal_peptide_metabolism1.08947115
96MP0005330_cardiomyopathy1.08731800
97MP0002295_abnormal_pulmonary_circulatio1.06435880
98MP0002882_abnormal_neuron_morphology1.03977208
99MP0000751_myopathy1.03818783
100MP0000955_abnormal_spinal_cord1.03116061
101MP0005408_hypopigmentation1.01912789
102MP0000749_muscle_degeneration1.00897999
103MP0003252_abnormal_bile_duct1.00239435
104MP0003631_nervous_system_phenotype0.98993317
105MP0005645_abnormal_hypothalamus_physiol0.96309925
106MP0001905_abnormal_dopamine_level0.94599202
107MP0002069_abnormal_eating/drinking_beha0.94439423
108MP0000767_abnormal_smooth_muscle0.93869863
109MP0001756_abnormal_urination0.93603104
110MP0004484_altered_response_of0.92167287
111MP0004036_abnormal_muscle_relaxation0.91473725
112MP0003787_abnormal_imprinting0.91418479
113MP0001664_abnormal_digestion0.91328950
114MP0001485_abnormal_pinna_reflex0.90470205
115MP0005165_increased_susceptibility_to0.90100563
116MP0002938_white_spotting0.88896177
117MP0005508_abnormal_skeleton_morphology0.86984875
118MP0002234_abnormal_pharynx_morphology0.85747511
119MP0001346_abnormal_lacrimal_gland0.84796662
120* MP0004085_abnormal_heartbeat0.83749175
121MP0001270_distended_abdomen0.81206680
122MP0002090_abnormal_vision0.81143555
123MP0002933_joint_inflammation0.80630551
124MP0010386_abnormal_urinary_bladder0.79049157
125MP0001849_ear_inflammation0.78960106
126MP0000163_abnormal_cartilage_morphology0.78054793
127MP0005076_abnormal_cell_differentiation0.77790967
128MP0005084_abnormal_gallbladder_morpholo0.77492391
129MP0008775_abnormal_heart_ventricle0.77270389
130MP0004019_abnormal_vitamin_homeostasis0.77216474
131MP0003690_abnormal_glial_cell0.76644907
132MP0005535_abnormal_body_temperature0.75689777
133MP0005409_darkened_coat_color0.75674704
134MP0002108_abnormal_muscle_morphology0.75370710
135MP0005310_abnormal_salivary_gland0.75355641
136MP0002152_abnormal_brain_morphology0.75168790
137MP0002269_muscular_atrophy0.75051081
138MP0005332_abnormal_amino_acid0.74899062
139MP0000604_amyloidosis0.74655179
140MP0000462_abnormal_digestive_system0.74319791
141MP0004087_abnormal_muscle_fiber0.70913935
142MP0001963_abnormal_hearing_physiology0.70652679
143MP0001661_extended_life_span0.69146185
144MP0003122_maternal_imprinting0.68699633
145MP0005166_decreased_susceptibility_to0.68406361
146MP0001765_abnormal_ion_homeostasis0.68178347
147MP0005375_adipose_tissue_phenotype0.67893005
148MP0002168_other_aberrant_phenotype0.67291325
149MP0006276_abnormal_autonomic_nervous0.66528883
150MP0000639_abnormal_adrenal_gland0.65746757
151MP0005620_abnormal_muscle_contractility0.65663020
152MP0002282_abnormal_trachea_morphology0.65518207
153MP0002118_abnormal_lipid_homeostasis0.65493607
154MP0002972_abnormal_cardiac_muscle0.65332519
155MP0000537_abnormal_urethra_morphology0.64788491
156MP0005167_abnormal_blood-brain_barrier0.63987235
157MP0010678_abnormal_skin_adnexa0.63933181
158MP0002229_neurodegeneration0.63601714
159MP0000569_abnormal_digit_pigmentation0.62577616
160MP0004043_abnormal_pH_regulation0.60736820
161MP0000631_abnormal_neuroendocrine_gland0.60097503
162MP0005551_abnormal_eye_electrophysiolog0.59969830
163MP0004142_abnormal_muscle_tone0.57925126
164MP0004215_abnormal_myocardial_fiber0.57128049
165MP0005595_abnormal_vascular_smooth0.57016569
166MP0000013_abnormal_adipose_tissue0.55983466
167MP0005448_abnormal_energy_balance0.50339608
168MP0004145_abnormal_muscle_electrophysio0.50123009
169MP0004742_abnormal_vestibular_system0.49085916
170MP0008875_abnormal_xenobiotic_pharmacok0.44080111
171MP0003137_abnormal_impulse_conducting0.43948802
172MP0003632_abnormal_nervous_system0.43432897
173MP0001943_abnormal_respiration0.43198305
174MP0002752_abnormal_somatic_nervous0.42077334
175MP0008004_abnormal_stomach_pH0.41863424
176MP0003045_fibrosis0.41488502

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.26168368
2Myokymia (HP:0002411)6.68055461
3Focal seizures (HP:0007359)5.75634478
4Epileptic encephalopathy (HP:0200134)5.64523829
5Protrusio acetabuli (HP:0003179)4.71835509
6Deep venous thrombosis (HP:0002625)4.48598687
7Febrile seizures (HP:0002373)4.45350144
8Atonic seizures (HP:0010819)3.89288946
9Broad-based gait (HP:0002136)3.84576741
10Visual hallucinations (HP:0002367)3.82246382
11Hyperventilation (HP:0002883)3.81996698
12Aplasia involving bones of the upper limbs (HP:0009823)3.81116519
13Aplasia of the phalanges of the hand (HP:0009802)3.81116519
14Aplasia involving bones of the extremities (HP:0009825)3.81116519
15Absence seizures (HP:0002121)3.67108125
16Annular pancreas (HP:0001734)3.59983215
17Generalized tonic-clonic seizures (HP:0002069)3.56399143
18Arterial tortuosity (HP:0005116)3.55455607
19Poor eye contact (HP:0000817)3.55415719
20Dialeptic seizures (HP:0011146)3.45957479
21Vascular tortuosity (HP:0004948)3.35959716
22Premature rupture of membranes (HP:0001788)3.32479271
23Impaired social interactions (HP:0000735)3.29142249
24Abnormal social behavior (HP:0012433)3.29142249
25Gaze-evoked nystagmus (HP:0000640)3.26704302
26Action tremor (HP:0002345)3.24518636
27Progressive cerebellar ataxia (HP:0002073)3.23267493
28Torticollis (HP:0000473)3.16761289
29Right ventricular cardiomyopathy (HP:0011663)3.09357461
30Fibular aplasia (HP:0002990)3.05558233
31Amblyopia (HP:0000646)3.03978783
32Stereotypic behavior (HP:0000733)2.96269826
33Abnormal eating behavior (HP:0100738)2.95813202
34Dysdiadochokinesis (HP:0002075)2.93496466
35Vascular calcification (HP:0004934)2.92244512
36Cardiovascular calcification (HP:0011915)2.91145510
37Atrophic scars (HP:0001075)2.85791472
38Depression (HP:0000716)2.83195802
39Ankyloglossia (HP:0010296)2.80516385
40Dysmetric saccades (HP:0000641)2.80403012
41Broad face (HP:0000283)2.77255968
42Abnormality of carpal bone ossification (HP:0006257)2.77034040
43Anxiety (HP:0000739)2.76015817
44Impaired vibration sensation in the lower limbs (HP:0002166)2.74484448
45Cervical subluxation (HP:0003308)2.74192444
46Mitral stenosis (HP:0001718)2.70104487
47Shallow orbits (HP:0000586)2.67957418
48Focal dystonia (HP:0004373)2.63612976
49Hydroxyprolinuria (HP:0003080)2.62906883
50Abnormality of proline metabolism (HP:0010907)2.62906883
51Postural instability (HP:0002172)2.61844469
52Aortic dissection (HP:0002647)2.58695003
53Dysmetria (HP:0001310)2.57901517
54Neonatal short-limb short stature (HP:0008921)2.55597832
55Obstructive sleep apnea (HP:0002870)2.55063538
56Aortic aneurysm (HP:0004942)2.54286446
57Ventricular fibrillation (HP:0001663)2.54030992
58Flat acetabular roof (HP:0003180)2.52849242
59Prolonged QT interval (HP:0001657)2.50547439
60Prolonged partial thromboplastin time (HP:0003645)2.50053100
61Fragile skin (HP:0001030)2.49719612
62Short nail (HP:0001799)2.49264286
63Urinary bladder sphincter dysfunction (HP:0002839)2.48836123
64Genetic anticipation (HP:0003743)2.44833432
65Coxa vara (HP:0002812)2.42809955
66Distal upper limb amyotrophy (HP:0007149)2.42606112
67Upper limb amyotrophy (HP:0009129)2.42606112
68Scanning speech (HP:0002168)2.42017593
69Craniofacial dystonia (HP:0012179)2.42001818
70Ankle clonus (HP:0011448)2.41774816
71Lower limb amyotrophy (HP:0007210)2.40329879
72Abnormal ossification of hand bones (HP:0005921)2.39582969
73Drooling (HP:0002307)2.36776989
74Excessive salivation (HP:0003781)2.36776989
75Epileptiform EEG discharges (HP:0011182)2.35340418
76Xanthomatosis (HP:0000991)2.34064587
77Abnormality of dentin (HP:0010299)2.33266540
78Bundle branch block (HP:0011710)2.32396511
79Truncal ataxia (HP:0002078)2.22990750
80Abnormal hand bone ossification (HP:0010660)2.22795626
81Status epilepticus (HP:0002133)2.22709765
82Hemiplegia (HP:0002301)2.22678088
83Abnormal EKG (HP:0003115)2.21495510
84Alopecia of scalp (HP:0002293)2.21334295
85Wormian bones (HP:0002645)2.20447504
86Syncope (HP:0001279)2.19843322
87Vertebral compression fractures (HP:0002953)2.18540514
88Cerebral aneurysm (HP:0004944)2.16522108
89Supranuclear gaze palsy (HP:0000605)2.15976066
90Impaired smooth pursuit (HP:0007772)2.15585382
91Spinal canal stenosis (HP:0003416)2.13633543
92Broad metatarsal (HP:0001783)2.13456589
93Hemiparesis (HP:0001269)2.13056562
94Papilledema (HP:0001085)2.12657357
95Asymmetry of the thorax (HP:0001555)2.11666857
96Abnormality of the nasal septum (HP:0000419)2.11341762
97Bradykinesia (HP:0002067)2.10474693
98Skin nodule (HP:0200036)2.09203173
99Spinal rigidity (HP:0003306)2.06502155
100Neonatal death (HP:0003811)2.06014497
101Incomplete penetrance (HP:0003829)2.05911061
102EEG with generalized epileptiform discharges (HP:0011198)2.05134132
103Spinal cord compression (HP:0002176)2.04778358
104Megalencephaly (HP:0001355)2.03704070
105Impaired vibratory sensation (HP:0002495)2.03279994
106Intention tremor (HP:0002080)2.02001442
107Urinary urgency (HP:0000012)2.01130014
108Resting tremor (HP:0002322)2.00589164
109Pointed chin (HP:0000307)1.98910303
110Lower limb asymmetry (HP:0100559)1.98395012
111Hand muscle atrophy (HP:0009130)1.98270865
112Pterygium (HP:0001059)1.97256514
113Small epiphyses (HP:0010585)1.96484031
114Hemorrhage of the eye (HP:0011885)1.96198948
115Protruding tongue (HP:0010808)1.94772146
116Thyroid-stimulating hormone excess (HP:0002925)1.91834961
117Joint hemorrhage (HP:0005261)1.91229060
118Milia (HP:0001056)1.90270303
119Thickened helices (HP:0000391)1.90191679
120Hypsarrhythmia (HP:0002521)1.89540288
121Fetal akinesia sequence (HP:0001989)1.89443568
122Abnormality of oral frenula (HP:0000190)1.89250885
123Abnormality of the acetabulum (HP:0003170)1.88956928
124Abnormality of glutamine family amino acid metabolism (HP:0010902)1.88887456
125Abnormality of the lower motor neuron (HP:0002366)1.87200701
126Mildly elevated creatine phosphokinase (HP:0008180)1.86491385
127Bladder diverticulum (HP:0000015)1.86483662
128Glomerulosclerosis (HP:0000096)1.84593637
129Epiphyseal dysplasia (HP:0002656)1.84201472
130Limited hip movement (HP:0008800)1.83982999
131Aneurysm (HP:0002617)1.83883779
132Blue irides (HP:0000635)1.83299661
133Absent speech (HP:0001344)1.82784969
134Palpebral edema (HP:0100540)1.82153395
135Late onset (HP:0003584)1.81305926
136Bronchomalacia (HP:0002780)1.81136199
137Ulnar bowing (HP:0003031)1.80266473
138Inability to walk (HP:0002540)1.80107554
139Follicular hyperkeratosis (HP:0007502)1.79983515
140Alacrima (HP:0000522)1.79467705
141Heart block (HP:0012722)1.79441891
142Mutism (HP:0002300)1.79300298
143Distal lower limb amyotrophy (HP:0008944)1.78147219
144Distal lower limb muscle weakness (HP:0009053)1.78025288
145Complement deficiency (HP:0004431)1.76097265
146Abnormality of the Achilles tendon (HP:0005109)1.76083502
147Deeply set eye (HP:0000490)1.75939454
148Hypercortisolism (HP:0001578)1.75313130
149Abnormal atrioventricular conduction (HP:0005150)1.74447630
150Hyperacusis (HP:0010780)1.71956927
151Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.70466768
152Bradycardia (HP:0001662)1.68741504
153Sleep apnea (HP:0010535)1.68568855
154Abnormality of ocular smooth pursuit (HP:0000617)1.67963530
155Coronal craniosynostosis (HP:0004440)1.66643419
156Generalized myoclonic seizures (HP:0002123)1.66401551
157Abnormality of the periventricular white matter (HP:0002518)1.66389948
158Cerebral inclusion bodies (HP:0100314)1.66155294
159Pigmentary retinal degeneration (HP:0001146)1.65322503
160Focal segmental glomerulosclerosis (HP:0000097)1.64382138
161Confusion (HP:0001289)1.64220638
162Hypercholesterolemia (HP:0003124)1.63884057
163Diplopia (HP:0000651)1.63370430
164Abnormality of binocular vision (HP:0011514)1.63370430
165Atrial fibrillation (HP:0005110)1.61560422
166Neurofibrillary tangles (HP:0002185)1.61354906
167Increased circulating renin level (HP:0000848)1.61153688
168Hypoventilation (HP:0002791)1.61068690
169Menorrhagia (HP:0000132)1.60585921
170Hypoplasia of the capital femoral epiphysis (HP:0003090)1.60062462
171Plantar hyperkeratosis (HP:0007556)1.59531888
172Oligodontia (HP:0000677)1.59514363
173Hypoplasia of dental enamel (HP:0006297)1.57810954
174Abnormality of aromatic amino acid family metabolism (HP:0004338)1.56865568
175Striae distensae (HP:0001065)1.55823316
176Achilles tendon contracture (HP:0001771)1.54252394
177Osteoarthritis (HP:0002758)1.53794074
178Sudden death (HP:0001699)1.53742385
179Tibial bowing (HP:0002982)1.53556787
180Natal tooth (HP:0000695)1.53125047
181Bowed forearm bones (HP:0003956)1.52759347
182Bowing of the arm (HP:0006488)1.52759347
183Abnormality of complement system (HP:0005339)1.51537904
184Advanced eruption of teeth (HP:0006288)1.51122137
185Acanthosis nigricans (HP:0000956)1.51045788
186Ventricular tachycardia (HP:0004756)1.50132874
187Nuclear cataract (HP:0100018)1.50025087
188Ankle contracture (HP:0006466)1.49379876

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.81082778
2EPHA24.89159751
3MST1R4.08120478
4NTRK33.94177953
5DAPK23.55963864
6MAP3K93.36435052
7MET3.01071828
8CASK2.89222111
9TRIB32.38934512
10PTK22.36335060
11ICK2.26792141
12MAP3K42.23992623
13KSR22.16954004
14RIPK42.12279179
15CDK192.09290828
16PDGFRA2.08779145
17MAP2K71.97882143
18DAPK11.86925995
19TNIK1.85823922
20MINK11.84011678
21WNK41.83411440
22EPHB11.83410995
23MYLK1.77269200
24PAK61.76408654
25PRKD31.70461816
26MAP3K131.67527818
27CAMKK11.66759406
28ERBB41.65699817
29MAP3K21.62059451
30NTRK21.61246803
31SIK11.60244052
32IRAK31.56955183
33ERN11.56647069
34KSR11.55893702
35SGK21.55530692
36MAP2K41.52581761
37NTRK11.51437052
38EPHB21.50082397
39FGFR41.47089256
40CCNB11.43686115
41TAOK11.43158298
42LATS11.42719923
43PRPF4B1.40033187
44CDK51.39566712
45SGK4941.37681948
46SGK2231.37681948
47SGK31.35411045
48FGFR21.28677481
49PLK21.27927235
50MARK11.26028985
51MAP3K121.24178839
52LIMK11.24167689
53WNK11.23412000
54STK381.22985383
55SIK21.20777661
56AKT31.20370599
57BMPR21.17651386
58OXSR11.16248231
59FGFR31.08521466
60CDK121.06213361
61ARAF1.04778626
62TTN1.01784525
63LMTK21.01535061
64FES0.99944793
65PAK40.99933893
66TESK10.98098595
67PINK10.97904077
68MAPKAPK30.97686856
69GRK50.96916597
70TYRO30.96606249
71TGFBR20.94668388
72PIK3CA0.94565853
73CAMKK20.94395086
74CDK80.94013652
75PDGFRB0.92538103
76RAF10.90540574
77SGK10.89958038
78MAP3K70.88961998
79CAMK10.88952169
80PRKCG0.88737164
81CAMK2A0.88715938
82PDPK10.87737967
83FRK0.86926743
84TIE10.86475990
85STK110.85971877
86NME10.83743844
87MARK20.82987262
88PNCK0.82962217
89ROCK10.82957875
90PTK2B0.82694630
91PDK10.81769716
92STK390.80485742
93DYRK1A0.78307177
94TRPM70.77499865
95DMPK0.76497456
96RIPK10.76295587
97MUSK0.76055072
98PTK60.76051713
99MTOR0.73809963
100CAMK2B0.73469295
101STK38L0.72441089
102PRKD20.70896251
103RET0.70615437
104MAP3K10.69054668
105ROCK20.68764925
106MAPK130.68158925
107MAP2K10.66480409
108MAP3K60.65879716
109PRKCH0.65583315
110CDK180.64229998
111SIK30.63779728
112CDK150.61903156
113PAK20.60894301
114FER0.53762294
115LATS20.53664999
116MAPK120.53577968
117CAMK40.53227992
118CDK11A0.52867284
119CDK140.51637891
120PRKAA20.51545004
121MELK0.50254127
122NEK90.49757773
123PKN20.49111517
124MAPK110.49011024
125MAPK70.48748180
126TAOK20.48704177
127PRKCE0.47997761
128TGFBR10.46985992
129MAP3K30.46533549
130FGFR10.45322670
131DAPK30.45223472
132NEK60.45110932
133RPS6KA30.44495629
134NEK20.44161848
135CAMK2D0.43770828
136INSRR0.42852971
137BMX0.42366787
138GSK3A0.41539638
139TNK20.40751066
140PRKCZ0.40730820
141MAPK150.40667132
142FLT30.40630910
143BRSK10.39934907
144PAK30.39770309
145MAP2K60.39748392
146PRKAA10.38787992
147ADRBK10.38198649
148PHKG20.37376386
149PHKG10.37376386
150FGR0.36977252
151PRKG20.36714573
152CDC42BPA0.34299512
153BRAF0.33720580
154DDR20.33021483
155PRKCA0.32898343
156CAMK2G0.32448699
157MOS0.31890018

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.33436513
2Synaptic vesicle cycle_Homo sapiens_hsa047212.83364878
3Olfactory transduction_Homo sapiens_hsa047402.72374128
4Circadian entrainment_Homo sapiens_hsa047132.56676119
5Amphetamine addiction_Homo sapiens_hsa050312.49272367
6Long-term potentiation_Homo sapiens_hsa047202.42654577
7Glutamatergic synapse_Homo sapiens_hsa047242.37166477
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.37029568
9Morphine addiction_Homo sapiens_hsa050322.36919342
10ECM-receptor interaction_Homo sapiens_hsa045122.34904008
11GABAergic synapse_Homo sapiens_hsa047272.32026255
12Complement and coagulation cascades_Homo sapiens_hsa046102.19793308
13Salivary secretion_Homo sapiens_hsa049702.16621365
14Maturity onset diabetes of the young_Homo sapiens_hsa049501.93532973
15Insulin secretion_Homo sapiens_hsa049111.91608025
16Cocaine addiction_Homo sapiens_hsa050301.89883818
17Dopaminergic synapse_Homo sapiens_hsa047281.89277707
18Gastric acid secretion_Homo sapiens_hsa049711.87382534
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.83253166
20Cholinergic synapse_Homo sapiens_hsa047251.79503949
21Renin secretion_Homo sapiens_hsa049241.78132510
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.74025620
23Fat digestion and absorption_Homo sapiens_hsa049751.68529008
24Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.61835313
25Nitrogen metabolism_Homo sapiens_hsa009101.58795522
26Calcium signaling pathway_Homo sapiens_hsa040201.58287460
27Taste transduction_Homo sapiens_hsa047421.58137284
28Oxytocin signaling pathway_Homo sapiens_hsa049211.56615529
29Cyanoamino acid metabolism_Homo sapiens_hsa004601.50432612
30Long-term depression_Homo sapiens_hsa047301.49655614
31Histidine metabolism_Homo sapiens_hsa003401.49259319
32Focal adhesion_Homo sapiens_hsa045101.44346871
33GnRH signaling pathway_Homo sapiens_hsa049121.43792154
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.42856309
35Serotonergic synapse_Homo sapiens_hsa047261.42614726
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.40310481
37Glycosaminoglycan degradation_Homo sapiens_hsa005311.39494299
38cAMP signaling pathway_Homo sapiens_hsa040241.35190368
39Phenylalanine metabolism_Homo sapiens_hsa003601.32063042
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.25909059
41Collecting duct acid secretion_Homo sapiens_hsa049661.23909247
42Gap junction_Homo sapiens_hsa045401.22682638
43Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.22198784
44Vitamin B6 metabolism_Homo sapiens_hsa007501.21218131
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.19932411
46Type II diabetes mellitus_Homo sapiens_hsa049301.18345355
47ABC transporters_Homo sapiens_hsa020101.13590971
48Phosphatidylinositol signaling system_Homo sapiens_hsa040701.12684841
49Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.10253453
50Pentose and glucuronate interconversions_Homo sapiens_hsa000401.09989900
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.08748752
52Steroid hormone biosynthesis_Homo sapiens_hsa001401.07504544
53PPAR signaling pathway_Homo sapiens_hsa033201.07036907
54cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02666563
55Starch and sucrose metabolism_Homo sapiens_hsa005001.00864787
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.97822837
57Adherens junction_Homo sapiens_hsa045200.96917963
58Arginine and proline metabolism_Homo sapiens_hsa003300.96713783
59Chemical carcinogenesis_Homo sapiens_hsa052040.95889278
60Vascular smooth muscle contraction_Homo sapiens_hsa042700.95484318
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93834375
62Estrogen signaling pathway_Homo sapiens_hsa049150.93015207
63Hippo signaling pathway_Homo sapiens_hsa043900.92852134
64Glioma_Homo sapiens_hsa052140.92549939
65Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.91904860
66Pancreatic secretion_Homo sapiens_hsa049720.91818753
67Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.89500328
68ErbB signaling pathway_Homo sapiens_hsa040120.88763104
69Melanogenesis_Homo sapiens_hsa049160.88161962
70Vitamin digestion and absorption_Homo sapiens_hsa049770.87327011
71Dorso-ventral axis formation_Homo sapiens_hsa043200.85953137
72Primary bile acid biosynthesis_Homo sapiens_hsa001200.84717274
73Tyrosine metabolism_Homo sapiens_hsa003500.81758171
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81678814
75Proteoglycans in cancer_Homo sapiens_hsa052050.81588834
76Bile secretion_Homo sapiens_hsa049760.80305425
77Axon guidance_Homo sapiens_hsa043600.79833021
78Tight junction_Homo sapiens_hsa045300.79706381
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.78405888
80Butanoate metabolism_Homo sapiens_hsa006500.77671433
81Basal cell carcinoma_Homo sapiens_hsa052170.77479831
82* Circadian rhythm_Homo sapiens_hsa047100.76652676
83Lysine degradation_Homo sapiens_hsa003100.75559470
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.75001393
85Vibrio cholerae infection_Homo sapiens_hsa051100.74750036
86Linoleic acid metabolism_Homo sapiens_hsa005910.74378145
87Thyroid hormone synthesis_Homo sapiens_hsa049180.74172642
88Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74012753
89Prion diseases_Homo sapiens_hsa050200.72488285
90Fructose and mannose metabolism_Homo sapiens_hsa000510.71673388
91MAPK signaling pathway_Homo sapiens_hsa040100.71517052
92Dilated cardiomyopathy_Homo sapiens_hsa054140.70851231
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70333975
94Retinol metabolism_Homo sapiens_hsa008300.69816973
95African trypanosomiasis_Homo sapiens_hsa051430.68903171
96Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.68303746
97Choline metabolism in cancer_Homo sapiens_hsa052310.67265211
98Insulin resistance_Homo sapiens_hsa049310.66613326
99Fatty acid degradation_Homo sapiens_hsa000710.65835553
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.64854253
101Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.63380227
102Glycerolipid metabolism_Homo sapiens_hsa005610.62493266
103Rap1 signaling pathway_Homo sapiens_hsa040150.62475399
104Galactose metabolism_Homo sapiens_hsa000520.62052803
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61764686
106Ras signaling pathway_Homo sapiens_hsa040140.61129603
107beta-Alanine metabolism_Homo sapiens_hsa004100.59958271
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57889996
109Fatty acid metabolism_Homo sapiens_hsa012120.55302299
110Inositol phosphate metabolism_Homo sapiens_hsa005620.55178987
111Amoebiasis_Homo sapiens_hsa051460.54565028
112Small cell lung cancer_Homo sapiens_hsa052220.54002181
113Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53568866
114Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.53406182
115Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52950446
116PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52845732
117Arginine biosynthesis_Homo sapiens_hsa002200.51426297
118Sulfur metabolism_Homo sapiens_hsa009200.51378575
119VEGF signaling pathway_Homo sapiens_hsa043700.51344197
120Mineral absorption_Homo sapiens_hsa049780.49680586
121Glucagon signaling pathway_Homo sapiens_hsa049220.48672408
122Ovarian steroidogenesis_Homo sapiens_hsa049130.46819871
123Neurotrophin signaling pathway_Homo sapiens_hsa047220.44929272
124Fatty acid biosynthesis_Homo sapiens_hsa000610.43446825
125Non-small cell lung cancer_Homo sapiens_hsa052230.43176444
126Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43122699
127Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43006694
128Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42940521
129Phototransduction_Homo sapiens_hsa047440.41680752
130Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41013608
131Prolactin signaling pathway_Homo sapiens_hsa049170.40585963
132Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40095767
133Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.38335170
134Sphingolipid signaling pathway_Homo sapiens_hsa040710.38200476
135Cardiac muscle contraction_Homo sapiens_hsa042600.38197227
136Oocyte meiosis_Homo sapiens_hsa041140.37015107
137Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36022845
138mTOR signaling pathway_Homo sapiens_hsa041500.35974508
139Chemokine signaling pathway_Homo sapiens_hsa040620.35909191
140Wnt signaling pathway_Homo sapiens_hsa043100.35503261
141Endometrial cancer_Homo sapiens_hsa052130.32758733
142Protein digestion and absorption_Homo sapiens_hsa049740.31664158
143Glycerophospholipid metabolism_Homo sapiens_hsa005640.30550612
144Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.29043688
145Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.28047375
146Endocytosis_Homo sapiens_hsa041440.27761610
147Type I diabetes mellitus_Homo sapiens_hsa049400.25833635
148Insulin signaling pathway_Homo sapiens_hsa049100.25725880

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »