NOXO1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an NADPH oxidase (NOX) organizer, which positively regulates NOX1 and NOX3. The protein contains a PX domain and two SH3 domains. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)7.14075716
2rRNA methylation (GO:0031167)6.54192430
3multicellular organism reproduction (GO:0032504)6.18516333
4fusion of sperm to egg plasma membrane (GO:0007342)5.98765773
5piRNA metabolic process (GO:0034587)5.94497240
6sperm capacitation (GO:0048240)5.93964213
7rRNA modification (GO:0000154)5.80908758
8cell wall macromolecule metabolic process (GO:0044036)5.68033905
9cell wall macromolecule catabolic process (GO:0016998)5.68033905
10intestinal epithelial cell development (GO:0060576)5.58178746
11cilium or flagellum-dependent cell motility (GO:0001539)5.53181956
12sperm-egg recognition (GO:0035036)5.34976890
13regulation of DNA endoreduplication (GO:0032875)5.33524768
14acrosome assembly (GO:0001675)5.24660528
15flavonoid metabolic process (GO:0009812)5.24385123
16axonemal dynein complex assembly (GO:0070286)5.20086658
17sperm motility (GO:0030317)5.15415824
18reproduction (GO:0000003)5.14767488
19motile cilium assembly (GO:0044458)5.08661537
20sensory perception of taste (GO:0050909)5.03283984
21cell-cell recognition (GO:0009988)5.01406199
22antibacterial humoral response (GO:0019731)5.00050549
23interferon-gamma secretion (GO:0072643)4.99715073
24calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.93791694
25antimicrobial humoral response (GO:0019730)4.84389618
26bundle of His cell to Purkinje myocyte communication (GO:0086069)4.82657518
27binding of sperm to zona pellucida (GO:0007339)4.72863520
28intestinal absorption (GO:0050892)4.71179002
29male meiosis (GO:0007140)4.67260632
30epithelial cilium movement (GO:0003351)4.63544494
31sulfate transmembrane transport (GO:1902358)4.63145182
32DNA deamination (GO:0045006)4.61243884
33UDP-N-acetylglucosamine metabolic process (GO:0006047)4.57976406
34spermatid development (GO:0007286)4.54657037
35acrosome reaction (GO:0007340)4.50387395
36cellular response to ATP (GO:0071318)4.46564397
37maintenance of gastrointestinal epithelium (GO:0030277)4.33105574
38sulfation (GO:0051923)4.31209073
39plasma membrane fusion (GO:0045026)4.25967466
40single fertilization (GO:0007338)4.16156751
41cilium movement (GO:0003341)4.14565805
42negative regulation of keratinocyte proliferation (GO:0010839)4.14447760
43hemidesmosome assembly (GO:0031581)4.05178266
44hepatocyte apoptotic process (GO:0097284)4.02484085
45viral transcription (GO:0019083)4.01198236
46sulfate transport (GO:0008272)3.97577044
47response to pheromone (GO:0019236)3.79643916
48translational termination (GO:0006415)3.79609611
493-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.77818193
50purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.77818193
51ribosomal small subunit assembly (GO:0000028)3.69840109
52fertilization (GO:0009566)3.69639742
53synaptonemal complex assembly (GO:0007130)3.66743106
54ribosomal large subunit biogenesis (GO:0042273)3.66731473
55proline biosynthetic process (GO:0006561)3.66436350
56DNA methylation involved in gamete generation (GO:0043046)3.64756401
57* regulation of respiratory burst (GO:0060263)3.60223714
58DNA strand renaturation (GO:0000733)3.57497140
59synaptonemal complex organization (GO:0070193)3.57392800
60O-glycan processing (GO:0016266)3.53459330
61digestive system process (GO:0022600)3.51182509
62meiotic cell cycle (GO:0051321)3.51162186
63regulation of guanylate cyclase activity (GO:0031282)3.50504364
64tight junction assembly (GO:0070830)3.50245980
65nucleotide transmembrane transport (GO:1901679)3.50192946
66negative regulation of epidermal cell differentiation (GO:0045605)3.47383444
67regulation of viral entry into host cell (GO:0046596)3.45935317
68cell proliferation in forebrain (GO:0021846)3.45502256
69negative regulation of cell aging (GO:0090344)3.45210431
70regulation of cilium movement (GO:0003352)3.44034367
71regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.43584522
72ribosomal small subunit biogenesis (GO:0042274)3.41667424
73meiotic chromosome segregation (GO:0045132)3.38831908
74translational elongation (GO:0006414)3.38178273
75pyrimidine nucleobase catabolic process (GO:0006208)3.37207183
76regulation of keratinocyte proliferation (GO:0010837)3.37127466
77regulation of cellular extravasation (GO:0002691)3.36961628
78nucleobase catabolic process (GO:0046113)3.35866747
79glutathione biosynthetic process (GO:0006750)3.33464002
80negative regulation of glial cell proliferation (GO:0060253)3.32123987
81epithelial structure maintenance (GO:0010669)3.31491334
82regulation of chemokine secretion (GO:0090196)3.28333548
83SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.26470493
84negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.26420813
85citrulline biosynthetic process (GO:0019240)3.26222044
86epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.25850722
87nonribosomal peptide biosynthetic process (GO:0019184)3.25837146
88purine ribonucleotide transport (GO:0015868)3.25283997
89water-soluble vitamin biosynthetic process (GO:0042364)3.25199756
90diol metabolic process (GO:0034311)3.25142577
91negative regulation of viral entry into host cell (GO:0046597)3.24667467
92cilium morphogenesis (GO:0060271)3.24588336
93negative regulation of DNA-dependent DNA replication (GO:2000104)3.24237121
94glycerol ether metabolic process (GO:0006662)3.22441812
95defense response to fungus (GO:0050832)3.20009050
96protein targeting to ER (GO:0045047)3.18631970
97primary alcohol catabolic process (GO:0034310)3.17297030
98cotranslational protein targeting to membrane (GO:0006613)3.17251744
99potassium ion export (GO:0071435)3.11748237
100cellular protein complex disassembly (GO:0043624)3.10823557
101chromosome condensation (GO:0030261)3.06363278
102protein polyglutamylation (GO:0018095)3.04606783
103positive regulation of Cdc42 GTPase activity (GO:0043089)3.03584519
104synaptic transmission, cholinergic (GO:0007271)3.00634740
105establishment of protein localization to endoplasmic reticulum (GO:0072599)3.00477969
106regulation of viral release from host cell (GO:1902186)3.00352531
107negative regulation of T cell differentiation in thymus (GO:0033085)2.97246775
108viral life cycle (GO:0019058)2.96011109
109protein localization to endoplasmic reticulum (GO:0070972)2.95911995
110ethanol metabolic process (GO:0006067)2.95386440
111cell differentiation involved in embryonic placenta development (GO:0060706)2.95260820
112lens fiber cell differentiation (GO:0070306)2.94843195
113spermatogenesis (GO:0007283)2.94499197
114transepithelial transport (GO:0070633)2.94354172
115sulfur compound transport (GO:0072348)2.94233056
116male gamete generation (GO:0048232)2.93588847
117sialylation (GO:0097503)2.92801380
118positive regulation of guanylate cyclase activity (GO:0031284)2.92751556
119auditory receptor cell differentiation (GO:0042491)2.91830759
120RNA destabilization (GO:0050779)2.90490596
121fucose catabolic process (GO:0019317)2.90240188
122L-fucose metabolic process (GO:0042354)2.90240188
123L-fucose catabolic process (GO:0042355)2.90240188
124neuromuscular synaptic transmission (GO:0007274)2.89445689
125positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.89241052
126mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.89241052
127endocrine pancreas development (GO:0031018)2.89240074
128ether metabolic process (GO:0018904)2.89069977
129intestinal cholesterol absorption (GO:0030299)2.88516190
130axoneme assembly (GO:0035082)2.88500703
131phenylpropanoid metabolic process (GO:0009698)2.87885921
132membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.87583814
133negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.85585336
134nucleoside transmembrane transport (GO:1901642)2.84906832
135regulation of cytokine production involved in inflammatory response (GO:1900015)2.84870913
136protein localization to Golgi apparatus (GO:0034067)2.83634916
137GDP-mannose metabolic process (GO:0019673)2.83496666
138detection of light stimulus involved in visual perception (GO:0050908)2.83372046
139detection of light stimulus involved in sensory perception (GO:0050962)2.83372046
140somite development (GO:0061053)2.82783007
141tRNA modification (GO:0006400)2.81781545
142sulfur amino acid catabolic process (GO:0000098)2.81726244
143microtubule depolymerization (GO:0007019)2.81324034
144bicarbonate transport (GO:0015701)2.80958348
145oligosaccharide biosynthetic process (GO:0009312)2.75651401
146membrane repolarization during action potential (GO:0086011)2.74730121
147arginine metabolic process (GO:0006525)2.74463517
148carnitine metabolic process (GO:0009437)2.73700227
149amino-acid betaine metabolic process (GO:0006577)2.71508443
150regulation of nuclear cell cycle DNA replication (GO:0033262)2.70787864
151sphingosine metabolic process (GO:0006670)2.69210080
152purinergic nucleotide receptor signaling pathway (GO:0035590)2.68959242
153respiratory chain complex IV assembly (GO:0008535)2.64540306
154regulation of synapse structural plasticity (GO:0051823)2.64187777
155arginine catabolic process (GO:0006527)2.61427449
156adenine nucleotide transport (GO:0051503)2.59925334
157establishment of protein localization to Golgi (GO:0072600)2.59831591
158positive regulation of fatty acid beta-oxidation (GO:0032000)2.57804239
159response to misfolded protein (GO:0051788)2.57682229
160indolalkylamine metabolic process (GO:0006586)2.57639070
161positive regulation of respiratory burst (GO:0060267)2.54506459
162short-chain fatty acid metabolic process (GO:0046459)2.51868603
163cytochrome complex assembly (GO:0017004)2.50846842
164GPI anchor metabolic process (GO:0006505)2.50752862
165cellular response to exogenous dsRNA (GO:0071360)2.50727060
166positive regulation of protein homooligomerization (GO:0032464)2.50432300
167fucosylation (GO:0036065)2.50238780
168regulation of protein kinase A signaling (GO:0010738)2.49893080
169neural tube formation (GO:0001841)2.49703984
170sensory perception of chemical stimulus (GO:0007606)2.48069853
171GPI anchor biosynthetic process (GO:0006506)2.47569229
172preassembly of GPI anchor in ER membrane (GO:0016254)2.47434609
173RNA methylation (GO:0001510)2.46679406
174response to ATP (GO:0033198)2.46175556
175peristalsis (GO:0030432)2.43963838
176thrombin receptor signaling pathway (GO:0070493)2.43074579
177negative regulation of transcription regulatory region DNA binding (GO:2000678)2.42919390
178cellular ketone body metabolic process (GO:0046950)2.42899584
179NADH dehydrogenase complex assembly (GO:0010257)2.42615362
180mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.42615362

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.21933204
2STAT6_21828071_ChIP-Seq_BEAS2B_Human4.52690176
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.50897189
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.26067892
5CDX2_20551321_ChIP-Seq_CACO-2_Human3.71495656
6SOX2_27498859_Chip-Seq_STOMACH_Mouse3.47219937
7GATA4_25053715_ChIP-Seq_YYC3_Human2.93551221
8CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.88386797
9GATA6_25053715_ChIP-Seq_YYC3_Human2.72154783
10ZNF274_21170338_ChIP-Seq_K562_Hela2.70787114
11CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.59167652
12SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.55954649
13GATA1_26923725_Chip-Seq_HPCs_Mouse2.27865233
14KAP1_22055183_ChIP-Seq_ESCs_Mouse2.26642308
15CTCF_27219007_Chip-Seq_Bcells_Human2.22869530
16IGF1R_20145208_ChIP-Seq_DFB_Human2.13738911
17HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.10915351
18EBNA2_21746931_ChIP-Seq_IB4-LCL_Human2.06018900
19* SOX2_20726797_ChIP-Seq_SW620_Human2.04543621
20RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.95538653
21LXR_22292898_ChIP-Seq_THP-1_Human1.94139885
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.90079854
23EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.84442836
24* ERA_21632823_ChIP-Seq_H3396_Human1.84033266
25RUNX1_27514584_Chip-Seq_MCF-7_Human1.83655625
26STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.77978356
27SRY_22984422_ChIP-ChIP_TESTIS_Rat1.77141305
28TET1_21451524_ChIP-Seq_MESCs_Mouse1.73762113
29* FOXP1_21924763_ChIP-Seq_HESCs_Human1.72667600
30YY1_22570637_ChIP-Seq_MALME-3M_Human1.71136094
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.69351111
32STAT1_17558387_ChIP-Seq_HELA_Human1.68979936
33FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.66235907
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.64371534
35ESR1_21235772_ChIP-Seq_MCF-7_Human1.63970944
36DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.62073142
37TAF2_19829295_ChIP-Seq_ESCs_Human1.61364145
38EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.56202485
39FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.55945660
40TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.55651717
41NANOG_20526341_ChIP-Seq_ESCs_Human1.54667942
42RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54659761
43KLF5_25053715_ChIP-Seq_YYC3_Human1.54162012
44MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.52981901
45EZH2_27294783_Chip-Seq_ESCs_Mouse1.52605250
46NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.52283158
47GATA3_21867929_ChIP-Seq_CD8_Mouse1.49469436
48SMC4_20622854_ChIP-Seq_HELA_Human1.48651365
49ERG_21242973_ChIP-ChIP_JURKAT_Human1.45546534
50VDR_21846776_ChIP-Seq_THP-1_Human1.44303061
51ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.44101744
52* OCT4_20526341_ChIP-Seq_ESCs_Human1.43967490
53AR_21909140_ChIP-Seq_LNCAP_Human1.42877910
54ETV2_25802403_ChIP-Seq_MESCs_Mouse1.38204509
55SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.37374733
56SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36991938
57PHF8_20622854_ChIP-Seq_HELA_Human1.36919388
58PPARA_22158963_ChIP-Seq_LIVER_Mouse1.36502767
59* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.35560683
60TP53_22127205_ChIP-Seq_IMR90_Human1.35481915
61MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.34649230
62SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.33761947
63EGR1_23403033_ChIP-Seq_LIVER_Mouse1.33552741
64DROSHA_22980978_ChIP-Seq_HELA_Human1.33273374
65PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.32121034
66* GATA3_21878914_ChIP-Seq_MCF-7_Human1.30769886
67NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.28939539
68ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.28772676
69CDX2_19796622_ChIP-Seq_MESCs_Mouse1.26966827
70BCOR_27268052_Chip-Seq_Bcells_Human1.26803931
71FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26169453
72SA1_27219007_Chip-Seq_Bcells_Human1.25983235
73* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.24677029
74GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.24660571
75* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.21771724
76ERG_20517297_ChIP-Seq_VCAP_Human1.19739764
77STAT1_20625510_ChIP-Seq_HELA_Human1.19717348
78JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.19715276
79SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19108926
80* ATF3_27146783_Chip-Seq_COLON_Human1.18665124
81SUZ12_27294783_Chip-Seq_ESCs_Mouse1.18258112
82CTCF_26484167_Chip-Seq_Bcells_Mouse1.17214694
83TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16598012
84EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.16487091
85* PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.16038052
86NCOR_22424771_ChIP-Seq_293T_Human1.15616225
87TP63_22573176_ChIP-Seq_HFKS_Human1.15540207
88RARG_19884340_ChIP-ChIP_MEFs_Mouse1.14249907
89OCT4_19829295_ChIP-Seq_ESCs_Human1.13965615
90* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.13169997
91PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.13059312
92PPAR_26484153_Chip-Seq_NCI-H1993_Human1.12992195
93SOX2_22085726_ChIP-Seq_NPCs_Mouse1.11891779
94CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.11227226
95JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.10866690
96CTCF_21964334_ChIP-Seq_BJAB-B_Human1.10623340
97FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.10457880
98NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.08742163
99SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.08655184
100HOXB7_26014856_ChIP-Seq_BT474_Human1.08184731
101TP53_22573176_ChIP-Seq_HFKS_Human1.08095277
102* BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.08073013
103PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.07252992
104RAD21_21589869_ChIP-Seq_MESCs_Mouse1.07081869
105ESR2_21235772_ChIP-Seq_MCF-7_Human1.06824707
106FOXO3_23340844_ChIP-Seq_DLD1_Human1.06708280
107REST_21632747_ChIP-Seq_MESCs_Mouse1.06521802
108RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.05828976
109BCL6_27268052_Chip-Seq_Bcells_Human1.05443396
110CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05022856
111ZNF263_19887448_ChIP-Seq_K562_Human1.04776676
112RACK7_27058665_Chip-Seq_MCF-7_Human1.04142082
113TCF4_18268006_ChIP-ChIP_LS174T_Human1.03597440
114TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03452970
115RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.03073011
116CREB1_26743006_Chip-Seq_LNCaP_Human1.02942440
117CTCF_20526341_ChIP-Seq_ESCs_Human1.02349418
118P63_26484246_Chip-Seq_KERATINOCYTES_Human1.02319268
119GABP_19822575_ChIP-Seq_HepG2_Human1.02244282
120RARA_24833708_ChIP-Seq_LIVER_Mouse1.00994253
121* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.00691184
122LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.00411792
123FOXM1_26456572_ChIP-Seq_MCF-7_Human1.00051148
124LXR_22158963_ChIP-Seq_LIVER_Mouse0.99785501
125CDX2_22108803_ChIP-Seq_LS180_Human0.99308569
126FOXH1_21741376_ChIP-Seq_ESCs_Human0.99284791
127P300_27268052_Chip-Seq_Bcells_Human0.98446370
128SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.98041616
129CEBPB_22108803_ChIP-Seq_LS180_Human0.97277684
130ELK4_26923725_Chip-Seq_MESODERM_Mouse0.97094339
131VDR_22108803_ChIP-Seq_LS180_Human0.96271268
132CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.94628991
133* P68_20966046_ChIP-Seq_HELA_Human0.94139737
134RUNX1_26923725_Chip-Seq_HPCs_Mouse0.94035268
135ETS1_21867929_ChIP-Seq_TH2_Mouse0.93264913
136RXRA_24833708_ChIP-Seq_LIVER_Mouse0.93144841
137EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.93133107
138HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.92971056
139SA1_27219007_Chip-Seq_ERYTHROID_Human0.92782648
140GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.92131177
141ELF1_20517297_ChIP-Seq_JURKAT_Human0.91937020
142SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.91722100
143SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.91722100
144ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.89545121
145RAC3_21632823_ChIP-Seq_H3396_Human0.89078460
146* E2F1_20622854_ChIP-Seq_HELA_Human0.87878240
147ESET_19884257_ChIP-Seq_ESCs_Mouse0.87302259
148STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.85512648
149FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85283966
150* P53_21459846_ChIP-Seq_SAOS-2_Human0.85172172
151FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.85139960
152FOXA1_25329375_ChIP-Seq_VCAP_Human0.84046474
153FOXA1_27270436_Chip-Seq_PROSTATE_Human0.84046474
154FLI1_21867929_ChIP-Seq_CD8_Mouse0.83889378
155GATA2_22383799_ChIP-Seq_G1ME_Mouse0.83372095
156P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.81874522
157SMC1_22415368_ChIP-Seq_MEFs_Mouse0.81750231
158* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.80641800
159* MYC_19829295_ChIP-Seq_ESCs_Human0.80625669
160RARB_24833708_ChIP-Seq_LIVER_Mouse0.79917311

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001986_abnormal_taste_sensitivity5.29675892
2MP0005410_abnormal_fertilization4.70289443
3MP0004264_abnormal_extraembryonic_tissu4.33666119
4MP0010234_abnormal_vibrissa_follicle3.89466728
5MP0000462_abnormal_digestive_system3.74869653
6MP0001873_stomach_inflammation3.52421434
7MP0005423_abnormal_somatic_nervous3.39541115
8MP0000490_abnormal_crypts_of3.20590284
9MP0008004_abnormal_stomach_pH3.19731421
10MP0005360_urolithiasis3.18120565
11MP0003866_abnormal_defecation3.18098812
12MP0010155_abnormal_intestine_physiology3.01932338
13MP0001663_abnormal_digestive_system2.94444323
14MP0003136_yellow_coat_color2.85778993
15MP0009379_abnormal_foot_pigmentation2.79627035
16MP0005381_digestive/alimentary_phenotyp2.71073741
17MP0003300_gastrointestinal_ulcer2.66417127
18MP0003693_abnormal_embryo_hatching2.60024445
19MP0001968_abnormal_touch/_nociception2.58587529
20MP0005451_abnormal_body_composition2.35819199
21MP0001666_abnormal_nutrient_absorption2.32666843
22MP0010386_abnormal_urinary_bladder2.30772655
23MP0002163_abnormal_gland_morphology2.22243825
24MP0005171_absent_coat_pigmentation2.18130074
25MP0004043_abnormal_pH_regulation2.09114255
26MP0001929_abnormal_gametogenesis2.08743390
27MP0000477_abnormal_intestine_morphology2.08142637
28MP0000537_abnormal_urethra_morphology2.05844557
29MP0005645_abnormal_hypothalamus_physiol1.99517725
30MP0002254_reproductive_system_inflammat1.91891443
31MP0005174_abnormal_tail_pigmentation1.91767847
32MP0001849_ear_inflammation1.90130366
33MP0001664_abnormal_digestion1.89983038
34MP0000566_synostosis1.89438928
35MP0005551_abnormal_eye_electrophysiolog1.84495704
36MP0001188_hyperpigmentation1.74640111
37MP0000427_abnormal_hair_cycle1.73064515
38MP0003453_abnormal_keratinocyte_physiol1.65671791
39MP0001756_abnormal_urination1.61131005
40MP0003698_abnormal_male_reproductive1.60951577
41MP0002653_abnormal_ependyma_morphology1.57523783
42MP0002160_abnormal_reproductive_system1.57314664
43MP0002736_abnormal_nociception_after1.57151096
44MP0004782_abnormal_surfactant_physiolog1.53891602
45MP0005085_abnormal_gallbladder_physiolo1.52750740
46MP0010352_gastrointestinal_tract_polyps1.52747153
47MP0002138_abnormal_hepatobiliary_system1.51882240
48MP0001485_abnormal_pinna_reflex1.49776734
49MP0009840_abnormal_foam_cell1.46363516
50MP0003718_maternal_effect1.43257046
51MP0000470_abnormal_stomach_morphology1.42807624
52MP0000613_abnormal_salivary_gland1.42178469
53MP0002638_abnormal_pupillary_reflex1.41464955
54MP0002735_abnormal_chemical_nociception1.41135032
55MP0000538_abnormal_urinary_bladder1.37848662
56MP0001970_abnormal_pain_threshold1.34074808
57MP0005379_endocrine/exocrine_gland_phen1.33287598
58MP0001765_abnormal_ion_homeostasis1.32299569
59MP0003315_abnormal_perineum_morphology1.32145976
60MP0004133_heterotaxia1.28875401
61MP0001764_abnormal_homeostasis1.28195090
62MP0002210_abnormal_sex_determination1.27159914
63MP0005310_abnormal_salivary_gland1.26647489
64MP0005332_abnormal_amino_acid1.25407047
65MP0005083_abnormal_biliary_tract1.25074215
66MP0004957_abnormal_blastocyst_morpholog1.21385058
67MP0006276_abnormal_autonomic_nervous1.21078204
68MP0002098_abnormal_vibrissa_morphology1.18508923
69MP0006054_spinal_hemorrhage1.16689399
70MP0003878_abnormal_ear_physiology1.15671117
71MP0005377_hearing/vestibular/ear_phenot1.15671117
72MP0002060_abnormal_skin_morphology1.14835600
73MP0002139_abnormal_hepatobiliary_system1.14136246
74MP0000653_abnormal_sex_gland1.14089075
75MP0000579_abnormal_nail_morphology1.13832698
76MP0004270_analgesia1.12751355
77MP0002796_impaired_skin_barrier1.12434443
78MP0002909_abnormal_adrenal_gland1.11360396
79MP0005409_darkened_coat_color1.11220757
80MP0008872_abnormal_physiological_respon1.10158707
81MP0005670_abnormal_white_adipose1.09938318
82MP0004858_abnormal_nervous_system1.09476594
83MP0001216_abnormal_epidermal_layer1.08428135
84MP0001905_abnormal_dopamine_level1.08279260
85MP0001145_abnormal_male_reproductive1.08224170
86MP0009643_abnormal_urine_homeostasis1.06214930
87MP0002277_abnormal_respiratory_mucosa1.05690307
88MP0005389_reproductive_system_phenotype1.04800455
89MP0010678_abnormal_skin_adnexa1.03080060
90MP0002734_abnormal_mechanical_nocicepti1.02828536
91MP0002557_abnormal_social/conspecific_i1.01768449
92* MP0000026_abnormal_inner_ear1.00679234
93MP0002733_abnormal_thermal_nociception1.00642749
94MP0005636_abnormal_mineral_homeostasis1.00023233
95MP0002282_abnormal_trachea_morphology0.99247142
96MP0005408_hypopigmentation0.99030830
97MP0000372_irregular_coat_pigmentation0.98969216
98MP0002161_abnormal_fertility/fecundity0.97899497
99MP0008995_early_reproductive_senescence0.94666161
100MP0000778_abnormal_nervous_system0.94051779
101MP0003011_delayed_dark_adaptation0.93946032
102MP0005365_abnormal_bile_salt0.93462040
103MP0001486_abnormal_startle_reflex0.92641953
104MP0005646_abnormal_pituitary_gland0.92452273
105MP0000013_abnormal_adipose_tissue0.92410459
106MP0004147_increased_porphyrin_level0.91423031
107MP0001919_abnormal_reproductive_system0.91388021
108MP0010329_abnormal_lipoprotein_level0.90750081
109MP0000678_abnormal_parathyroid_gland0.89654073
110MP0004885_abnormal_endolymph0.88394534
111MP0004019_abnormal_vitamin_homeostasis0.88119342
112MP0004947_skin_inflammation0.87418952
113MP0000230_abnormal_systemic_arterial0.85570054
114MP0000516_abnormal_urinary_system0.82701136
115MP0005367_renal/urinary_system_phenotyp0.82701136
116MP0003868_abnormal_feces_composition0.81839759
117MP0005084_abnormal_gallbladder_morpholo0.78465778
118MP0001502_abnormal_circadian_rhythm0.78105791
119MP0009333_abnormal_splenocyte_physiolog0.77898269
120MP0000685_abnormal_immune_system0.76682086
121MP0001963_abnormal_hearing_physiology0.76572206
122MP0001270_distended_abdomen0.76246082
123MP0004130_abnormal_muscle_cell0.75327565
124MP0002249_abnormal_larynx_morphology0.74780645
125MP0005584_abnormal_enzyme/coenzyme_acti0.74683739
126MP0002118_abnormal_lipid_homeostasis0.74247902
127MP0002069_abnormal_eating/drinking_beha0.73219320
128MP0003699_abnormal_female_reproductive0.72649337
129MP0002752_abnormal_somatic_nervous0.72193102
130MP0002572_abnormal_emotion/affect_behav0.71843298
131MP0005167_abnormal_blood-brain_barrier0.69235356
132MP0009785_altered_susceptibility_to0.68633018
133MP0000377_abnormal_hair_follicle0.67497267
134MP0005253_abnormal_eye_physiology0.67483090
135MP0003252_abnormal_bile_duct0.67474784
136MP0003806_abnormal_nucleotide_metabolis0.67409234
137MP0002229_neurodegeneration0.66010579
138MP0003123_paternal_imprinting0.65672893
139MP0008877_abnormal_DNA_methylation0.64387019
140MP0002876_abnormal_thyroid_physiology0.62945084
141MP0003115_abnormal_respiratory_system0.62873395
142MP0005501_abnormal_skin_physiology0.61196054
143MP0000015_abnormal_ear_pigmentation0.60083958
144MP0001119_abnormal_female_reproductive0.60067933
145MP0003119_abnormal_digestive_system0.59951515
146MP0003879_abnormal_hair_cell0.59517697
147MP0002102_abnormal_ear_morphology0.59255501
148MP0009384_cardiac_valve_regurgitation0.58558648
149MP0003763_abnormal_thymus_physiology0.58448024
150MP0001845_abnormal_inflammatory_respons0.57216206
151MP0005166_decreased_susceptibility_to0.56926418
152MP0002693_abnormal_pancreas_physiology0.56034223
153MP0003787_abnormal_imprinting0.55170248
154MP0010094_abnormal_chromosome_stability0.54384013
155MP0002089_abnormal_postnatal_growth/wei0.54057075
156MP0000467_abnormal_esophagus_morphology0.52861456
157MP0010771_integument_phenotype0.52799926
158MP0008875_abnormal_xenobiotic_pharmacok0.52322034
159MP0001881_abnormal_mammary_gland0.51302937
160MP0002136_abnormal_kidney_physiology0.51217186

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.54377759
2Ventricular fibrillation (HP:0001663)4.98097291
3Ileus (HP:0002595)4.96680656
4Chronic bronchitis (HP:0004469)4.81100567
5Absent/shortened dynein arms (HP:0200106)4.78615975
6Dynein arm defect of respiratory motile cilia (HP:0012255)4.78615975
7Abnormal respiratory motile cilium physiology (HP:0012261)4.61588584
8Rib fusion (HP:0000902)4.53656063
9Male infertility (HP:0003251)4.44810758
10Congenital sensorineural hearing impairment (HP:0008527)4.37110027
11Pustule (HP:0200039)4.34299686
12Decreased circulating renin level (HP:0003351)4.20185118
13Tubular atrophy (HP:0000092)4.09643933
14Right ventricular cardiomyopathy (HP:0011663)4.07411622
15Rhinitis (HP:0012384)4.04526728
16Abnormality of midbrain morphology (HP:0002418)3.99743408
17Molar tooth sign on MRI (HP:0002419)3.99743408
18Chronic hepatic failure (HP:0100626)3.95517386
19Milia (HP:0001056)3.94771079
20Abnormality of small intestinal villus morphology (HP:0011472)3.77602752
21Villous atrophy (HP:0011473)3.77602752
22Nephronophthisis (HP:0000090)3.70991183
23Pili torti (HP:0003777)3.68793438
24Abnormal respiratory motile cilium morphology (HP:0005938)3.67426698
25Abnormal respiratory epithelium morphology (HP:0012253)3.67426698
26Pendular nystagmus (HP:0012043)3.56160237
27Attenuation of retinal blood vessels (HP:0007843)3.52494741
28Infertility (HP:0000789)3.49798552
29Onycholysis (HP:0001806)3.47940289
30Bronchiectasis (HP:0002110)3.41524648
31Nasal polyposis (HP:0100582)3.36666127
32Congenital stationary night blindness (HP:0007642)3.27547944
33Bony spicule pigmentary retinopathy (HP:0007737)3.16917885
34Amniotic constriction ring (HP:0009775)3.15736812
35Abnormality of placental membranes (HP:0011409)3.15736812
36Micronodular cirrhosis (HP:0001413)3.13761919
37Reticulocytopenia (HP:0001896)3.08041688
38Hyperactive renin-angiotensin system (HP:0000841)3.06318038
39Fragile nails (HP:0001808)3.02627495
40Abnormal ciliary motility (HP:0012262)3.01799380
41Metabolic alkalosis (HP:0200114)2.93863123
42Patellar aplasia (HP:0006443)2.91592012
43Abdominal distention (HP:0003270)2.88323655
44Abnormality of macular pigmentation (HP:0008002)2.87218813
45Abnormality of the gastric mucosa (HP:0004295)2.85327970
46Bronchitis (HP:0012387)2.83528366
47Plantar hyperkeratosis (HP:0007556)2.81152782
48Abnormality of chloride homeostasis (HP:0011422)2.80898275
49Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.80860438
50Abnormality of the renal medulla (HP:0100957)2.77774785
51Aplasia/Hypoplasia of the patella (HP:0006498)2.76599293
52Amelogenesis imperfecta (HP:0000705)2.75270751
53Type 2 muscle fiber atrophy (HP:0003554)2.67639005
54Atrophic scars (HP:0001075)2.64061654
55Abnormality of the nasal mucosa (HP:0000433)2.62589606
56Pancreatic cysts (HP:0001737)2.61280977
57Submucous cleft hard palate (HP:0000176)2.60403507
58Hypoplasia of dental enamel (HP:0006297)2.58743614
59Abnormal hair laboratory examination (HP:0003328)2.52991501
60Fragile skin (HP:0001030)2.51390611
61Abnormality of the 1st metacarpal (HP:0010009)2.51019052
62Malnutrition (HP:0004395)2.50849139
63Rectal prolapse (HP:0002035)2.49822220
64Facial hemangioma (HP:0000329)2.49707139
65Abnormal biliary tract morphology (HP:0012440)2.45548135
66Bile duct proliferation (HP:0001408)2.44980078
67Abnormal biliary tract physiology (HP:0012439)2.44980078
68Biliary tract neoplasm (HP:0100574)2.43482484
69Abnormal hemoglobin (HP:0011902)2.41519744
7011 pairs of ribs (HP:0000878)2.39918100
71Abnormal albumin level (HP:0012116)2.36267671
72Hypoalbuminemia (HP:0003073)2.36267671
73Trismus (HP:0000211)2.35874696
74Polydipsia (HP:0001959)2.32686114
75Abnormal drinking behavior (HP:0030082)2.32686114
76Absent speech (HP:0001344)2.32618011
77True hermaphroditism (HP:0010459)2.32517798
78Inflammation of the large intestine (HP:0002037)2.31106608
79Woolly hair (HP:0002224)2.30143284
80Abnormality of the distal phalanx of the thumb (HP:0009617)2.29950406
81Delayed CNS myelination (HP:0002188)2.29498883
82Cheilitis (HP:0100825)2.29444360
83Cystic liver disease (HP:0006706)2.28907751
84Popliteal pterygium (HP:0009756)2.24273359
85Squamous cell carcinoma (HP:0002860)2.23926501
86Thyroid-stimulating hormone excess (HP:0002925)2.23831028
87Occipital encephalocele (HP:0002085)2.23663238
88Ureteral stenosis (HP:0000071)2.22323349
89Muscle fiber atrophy (HP:0100295)2.21580154
90Flat acetabular roof (HP:0003180)2.21538982
91Pancreatic fibrosis (HP:0100732)2.21433781
92Methylmalonic aciduria (HP:0012120)2.19623339
93Abnormal spermatogenesis (HP:0008669)2.18970969
94Adrenal hypoplasia (HP:0000835)2.18135868
95Abnormal rod and cone electroretinograms (HP:0008323)2.17545610
96Abnormality of cells of the erythroid lineage (HP:0012130)2.17468391
97Lipid accumulation in hepatocytes (HP:0006561)2.16475208
98Abnormality of the phalanges of the hallux (HP:0010057)2.16400597
99Abnormality of dental color (HP:0011073)2.14687009
100Annular pancreas (HP:0001734)2.13370035
101Abnormal number of erythroid precursors (HP:0012131)2.12975877
102Poikiloderma (HP:0001029)2.12482716
103Chronic sinusitis (HP:0011109)2.12288653
104Abnormality of dicarboxylic acid metabolism (HP:0010995)2.11196782
105Dicarboxylic aciduria (HP:0003215)2.11196782
106Enlarged epiphyses (HP:0010580)2.11135095
107Macrocytic anemia (HP:0001972)2.10465693
108Rectovaginal fistula (HP:0000143)2.10298595
109Rectal fistula (HP:0100590)2.10298595
110Testicular atrophy (HP:0000029)2.09961167
111Short phalanx of the thumb (HP:0009660)2.09404378
112Tubulointerstitial fibrosis (HP:0005576)2.09354774
113Polygenic inheritance (HP:0010982)2.08601392
114Widely patent fontanelles and sutures (HP:0004492)2.07940203
115Ridged nail (HP:0001807)2.07791609
116Vaginal fistula (HP:0004320)2.06771730
117Abnormality of glutamine family amino acid metabolism (HP:0010902)2.05081906
118Chorioretinal atrophy (HP:0000533)2.04105352
119Gastrointestinal inflammation (HP:0004386)2.03669069
120Alkalosis (HP:0001948)2.03597584
121Pallor (HP:0000980)2.02901124
122Thrombocytosis (HP:0001894)2.01206111
123Akinesia (HP:0002304)2.00265449
124Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.98759381
125Ureteral obstruction (HP:0006000)1.98641817
126Fatigable weakness (HP:0003473)1.98530416
127Abnormality of the neuromuscular junction (HP:0003398)1.98530416
128Posterior subcapsular cataract (HP:0007787)1.98490361
129Flat capital femoral epiphysis (HP:0003370)1.98371270
130Fetal akinesia sequence (HP:0001989)1.97763404
131Azoospermia (HP:0000027)1.97407697
132Premature loss of primary teeth (HP:0006323)1.94073240
133Long clavicles (HP:0000890)1.92841898
134Autoimmune hemolytic anemia (HP:0001890)1.91717081
135Polyuria (HP:0000103)1.91567297
136Dehydration (HP:0001944)1.91400635
137Abnormal urine output (HP:0012590)1.91062697
138Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.89593051
139Aplasia/Hypoplasia of the sacrum (HP:0008517)1.88535642
140Conjugated hyperbilirubinemia (HP:0002908)1.88465510
141Sclerocornea (HP:0000647)1.88416748
142Absent thumb (HP:0009777)1.88198378
143Curly hair (HP:0002212)1.86962059
144Stage 5 chronic kidney disease (HP:0003774)1.86804260
145Microretrognathia (HP:0000308)1.86316173
146Aplasia cutis congenita (HP:0001057)1.85165988
147Abnormality of renal excretion (HP:0011036)1.84259902
148Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.82588018
149Renal Fanconi syndrome (HP:0001994)1.82124418
150Short femoral neck (HP:0100864)1.82111849
151Medial flaring of the eyebrow (HP:0010747)1.81816639
152Delayed epiphyseal ossification (HP:0002663)1.81270569
153Glycosuria (HP:0003076)1.78434710
154Abnormality of urine glucose concentration (HP:0011016)1.78434710
155Retinitis pigmentosa (HP:0000510)1.77105520
156Increased muscle lipid content (HP:0009058)1.76846952
157Esophageal varix (HP:0002040)1.76809804
158Hypoplasia of the radius (HP:0002984)1.76558515
159Hyperparathyroidism (HP:0000843)1.76545664
160Severe visual impairment (HP:0001141)1.75690078
161Abnormality of renin-angiotensin system (HP:0000847)1.74946205
162Chronic diarrhea (HP:0002028)1.71242052
163Short 1st metacarpal (HP:0010034)1.71201550
164Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.71201550
165Flattened epiphyses (HP:0003071)1.70705480
166Intestinal fistula (HP:0100819)1.70349156
167Goiter (HP:0000853)1.69997526
168Xerostomia (HP:0000217)1.69926219
169Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.69727104
170Periodontitis (HP:0000704)1.68719959
171Syncope (HP:0001279)1.68315804
172Thin bony cortex (HP:0002753)1.67913500
173Abnormal tarsal ossification (HP:0008369)1.66747901
174Palmoplantar hyperkeratosis (HP:0000972)1.65890395
175Progressive hearing impairment (HP:0001730)1.65774933
176Abnormality of the preputium (HP:0100587)1.65688952
177Uterine neoplasm (HP:0010784)1.65535703
178Neoplasm of the small intestine (HP:0100833)1.64750218

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK24.68605603
2EPHA23.45883525
3TESK13.44146688
4FRK3.21510259
5LATS13.03195557
6SIK22.93806855
7MST1R2.90367891
8ACVR1B2.82996676
9BCKDK2.79924086
10PDK42.74885626
11PDK32.74885626
12EEF2K2.73503872
13MST42.65494598
14TRIM282.59320727
15ADRBK22.58985408
16PRKD32.57001650
17NME12.52794340
18MUSK2.44064520
19STK38L2.35303847
20MAP2K22.30315201
21PINK12.21680030
22BCR2.06586021
23PRKG22.02622623
24OXSR11.94131890
25MAP2K61.93704747
26NUAK11.78266467
27CDK81.67646511
28SIK31.61865313
29MAPK151.61075266
30SIK11.60609415
31EIF2AK11.60139231
32TTK1.60040723
33MAPKAPK31.55901192
34RIPK11.54955150
35NEK21.49604387
36RPS6KB21.46252734
37EPHB21.45603284
38STK391.42160281
39TNK21.41756553
40MAP4K21.41377576
41TAOK31.35365123
42PDK21.34297391
43ADRBK11.33964902
44DYRK21.32987350
45WNK31.28826418
46TAOK11.27044601
47MAP3K121.26797595
48PTK61.25776868
49ERBB41.21824624
50CDK91.20495276
51MAP3K101.18436217
52DAPK21.15545869
53WNK41.14790009
54ERN11.09394667
55STK31.09102428
56STK101.08245279
57NME21.08070503
58MAP2K71.06983444
59BLK1.06404469
60BRAF1.02459826
61STK161.00612066
62BMPR1B0.96608758
63ICK0.94174723
64MAP3K110.91816590
65AURKB0.89025758
66NEK60.88370131
67MATK0.85472062
68PBK0.85399899
69MAP3K20.85368771
70DYRK1B0.79519131
71TLK10.79254914
72MAP4K10.77233108
73FER0.75898496
74PIK3CA0.75625251
75STK380.74845275
76PHKG10.74670384
77PHKG20.74670384
78PIM20.74416558
79TXK0.73167771
80PRKAA20.72808713
81PTK20.71766932
82TESK20.70924307
83CASK0.68970477
84PAK40.68288186
85MAP3K10.67934981
86MINK10.67622893
87ERBB20.67228346
88BTK0.66933340
89MAP2K10.66527263
90ARAF0.66334471
91PASK0.64715268
92PRKCI0.62485978
93MAPKAPK50.62211314
94IRAK30.61900807
95MAP3K40.61020053
96ITK0.58450131
97MAPK130.58365331
98IRAK20.57739674
99NLK0.57506962
100HIPK20.57442328
101CHEK20.57045421
102INSRR0.56881860
103CSNK1A10.56486053
104TBK10.55925198
105EPHA40.53482764
106MAP3K80.53382045
107PRKCE0.51768008
108PRKCZ0.51741878
109MAP3K60.51519556
110PTK2B0.51378845
111CHUK0.50832577
112IRAK10.50443818
113PLK10.48344434
114MAPK110.47520482
115STK110.47152910
116TYK20.46753825
117DYRK30.45903535
118NEK10.45691856
119PAK10.44049623
120MELK0.43652155
121RPS6KA20.42353835
122BUB10.41314309
123GRK10.40612840
124TRPM70.40592196
125MAP3K90.39754685
126DDR20.39458514
127CAMK2D0.39230130
128MYLK0.38334888
129MET0.38180768
130DAPK10.37004833
131PRKCH0.36495425
132TEC0.34623265
133MOS0.34338782
134PLK20.33507456
135GRK60.32740734
136IGF1R0.32638084
137CSNK1G10.32193461
138PRKAA10.32175506
139LRRK20.31820976
140MAP3K70.31673895
141MAP2K40.30863307
142CDK60.30859920
143BMPR20.30653482
144DMPK0.30431309
145ERBB30.28092343
146PRKACA0.27656608
147CDC42BPA0.27024740
148RPS6KA10.27014971
149PDPK10.26435665
150IKBKE0.26330731
151PRKCG0.26277015
152CSNK1G30.25496576
153PDK10.25405267
154PRKCA0.24317887
155EPHA30.24028546
156CDK50.23277812
157RPS6KA40.22713042

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009203.68438416
2Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.50205764
3Maturity onset diabetes of the young_Homo sapiens_hsa049503.45848765
4Caffeine metabolism_Homo sapiens_hsa002323.42013076
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.33444325
6Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.98709791
7Ribosome_Homo sapiens_hsa030102.87975460
8Mineral absorption_Homo sapiens_hsa049782.77193014
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.61644695
10Fat digestion and absorption_Homo sapiens_hsa049752.54749141
11Linoleic acid metabolism_Homo sapiens_hsa005912.53263527
12Nitrogen metabolism_Homo sapiens_hsa009102.51937724
13Fatty acid biosynthesis_Homo sapiens_hsa000612.50603527
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.49059197
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.47268533
16Pentose and glucuronate interconversions_Homo sapiens_hsa000402.46312161
17Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.35178845
18Pentose phosphate pathway_Homo sapiens_hsa000302.32202503
19Taste transduction_Homo sapiens_hsa047422.20661102
20Fructose and mannose metabolism_Homo sapiens_hsa000512.14920456
21Histidine metabolism_Homo sapiens_hsa003402.09384739
22Glutathione metabolism_Homo sapiens_hsa004802.08760840
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.02850857
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.00123671
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.88499802
26Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.87050728
27Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.80686826
28Phototransduction_Homo sapiens_hsa047441.75649756
29Chemical carcinogenesis_Homo sapiens_hsa052041.72130663
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.63605242
31Pyruvate metabolism_Homo sapiens_hsa006201.62600256
32Cyanoamino acid metabolism_Homo sapiens_hsa004601.62061856
33Huntingtons disease_Homo sapiens_hsa050161.61195670
34Arachidonic acid metabolism_Homo sapiens_hsa005901.60861125
35Oxidative phosphorylation_Homo sapiens_hsa001901.52856952
36N-Glycan biosynthesis_Homo sapiens_hsa005101.41746313
37Fatty acid metabolism_Homo sapiens_hsa012121.41315510
38Homologous recombination_Homo sapiens_hsa034401.40958324
39Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.33128667
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.28985434
41Ether lipid metabolism_Homo sapiens_hsa005651.26343359
42Parkinsons disease_Homo sapiens_hsa050121.24384035
43Pancreatic secretion_Homo sapiens_hsa049721.24146454
44Tight junction_Homo sapiens_hsa045301.21881784
45Glycerolipid metabolism_Homo sapiens_hsa005611.20775767
46Butanoate metabolism_Homo sapiens_hsa006501.20186371
47Thyroid hormone synthesis_Homo sapiens_hsa049181.18259629
48Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.16975798
49Sulfur relay system_Homo sapiens_hsa041221.15381841
50Protein digestion and absorption_Homo sapiens_hsa049741.14646548
51Alzheimers disease_Homo sapiens_hsa050101.06130928
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.05626044
53Bile secretion_Homo sapiens_hsa049760.99434242
54Regulation of autophagy_Homo sapiens_hsa041400.97994130
55Renin-angiotensin system_Homo sapiens_hsa046140.96221539
56Fatty acid degradation_Homo sapiens_hsa000710.94760216
57Galactose metabolism_Homo sapiens_hsa000520.93250864
58Thyroid cancer_Homo sapiens_hsa052160.91631640
59Steroid biosynthesis_Homo sapiens_hsa001000.91287909
60Other glycan degradation_Homo sapiens_hsa005110.89513349
61Leukocyte transendothelial migration_Homo sapiens_hsa046700.89119174
62Hepatitis C_Homo sapiens_hsa051600.88231001
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.86945624
64Peroxisome_Homo sapiens_hsa041460.85594043
65Bladder cancer_Homo sapiens_hsa052190.85498381
66Retinol metabolism_Homo sapiens_hsa008300.84041263
67Arginine and proline metabolism_Homo sapiens_hsa003300.82347122
68Selenocompound metabolism_Homo sapiens_hsa004500.80791924
69Folate biosynthesis_Homo sapiens_hsa007900.80545411
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.79772923
71Tryptophan metabolism_Homo sapiens_hsa003800.77239983
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.77210328
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76597832
74Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.75535667
75Fanconi anemia pathway_Homo sapiens_hsa034600.75242875
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.73685370
77Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.72272579
78Nicotine addiction_Homo sapiens_hsa050330.71379915
79Toxoplasmosis_Homo sapiens_hsa051450.67803919
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.65625917
81Glycerophospholipid metabolism_Homo sapiens_hsa005640.64997107
82Starch and sucrose metabolism_Homo sapiens_hsa005000.64559730
83Purine metabolism_Homo sapiens_hsa002300.61760368
84Arginine biosynthesis_Homo sapiens_hsa002200.61548495
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60766103
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.59058662
87NOD-like receptor signaling pathway_Homo sapiens_hsa046210.58536795
88Adherens junction_Homo sapiens_hsa045200.58390674
89Influenza A_Homo sapiens_hsa051640.58090069
90Base excision repair_Homo sapiens_hsa034100.57919755
91Small cell lung cancer_Homo sapiens_hsa052220.55734271
92Carbon metabolism_Homo sapiens_hsa012000.55056621
93Intestinal immune network for IgA production_Homo sapiens_hsa046720.54876305
94Notch signaling pathway_Homo sapiens_hsa043300.54453783
95Propanoate metabolism_Homo sapiens_hsa006400.52163628
96Calcium signaling pathway_Homo sapiens_hsa040200.51894139
97Metabolic pathways_Homo sapiens_hsa011000.51626323
98Insulin secretion_Homo sapiens_hsa049110.51035825
99Basal transcription factors_Homo sapiens_hsa030220.50165987
100Antigen processing and presentation_Homo sapiens_hsa046120.48196930
101Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46567383
102Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.44641853
103Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44550896
104Morphine addiction_Homo sapiens_hsa050320.44479683
105Sphingolipid metabolism_Homo sapiens_hsa006000.44204539
106Inositol phosphate metabolism_Homo sapiens_hsa005620.43198347
107Cholinergic synapse_Homo sapiens_hsa047250.43003632
108Pyrimidine metabolism_Homo sapiens_hsa002400.42891687
109Vitamin digestion and absorption_Homo sapiens_hsa049770.42007281
110AMPK signaling pathway_Homo sapiens_hsa041520.40963033
111Cardiac muscle contraction_Homo sapiens_hsa042600.38660230
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.38466192
113p53 signaling pathway_Homo sapiens_hsa041150.38354306
114Salmonella infection_Homo sapiens_hsa051320.37316919
115Olfactory transduction_Homo sapiens_hsa047400.36921290
116TNF signaling pathway_Homo sapiens_hsa046680.36404507
117Protein export_Homo sapiens_hsa030600.36276672
118Collecting duct acid secretion_Homo sapiens_hsa049660.35092589
119Tyrosine metabolism_Homo sapiens_hsa003500.34327491
120beta-Alanine metabolism_Homo sapiens_hsa004100.32849099
121Legionellosis_Homo sapiens_hsa051340.32787822
122RNA polymerase_Homo sapiens_hsa030200.32556356
123Axon guidance_Homo sapiens_hsa043600.31418466
124Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.31133995
125Glutamatergic synapse_Homo sapiens_hsa047240.31008780
126Serotonergic synapse_Homo sapiens_hsa047260.30499784
127Dopaminergic synapse_Homo sapiens_hsa047280.30316141
128Ovarian steroidogenesis_Homo sapiens_hsa049130.30137386
129Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.29573898
130ABC transporters_Homo sapiens_hsa020100.29446027
131Phenylalanine metabolism_Homo sapiens_hsa003600.28885983
1322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.28798020
133PPAR signaling pathway_Homo sapiens_hsa033200.27942631
134Glucagon signaling pathway_Homo sapiens_hsa049220.27773119
135Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.27646146
136RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.27566858
137Vibrio cholerae infection_Homo sapiens_hsa051100.27527528
138Dorso-ventral axis formation_Homo sapiens_hsa043200.26327727
139ECM-receptor interaction_Homo sapiens_hsa045120.24738900
140Gastric acid secretion_Homo sapiens_hsa049710.23826320
141Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.22346668
142Leishmaniasis_Homo sapiens_hsa051400.21289271
143Cysteine and methionine metabolism_Homo sapiens_hsa002700.20802366
144Cell cycle_Homo sapiens_hsa041100.19213259
145Pancreatic cancer_Homo sapiens_hsa052120.18993485
146Pertussis_Homo sapiens_hsa051330.18074807
147Lysine degradation_Homo sapiens_hsa003100.17689161

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