NOX4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1urate metabolic process (GO:0046415)7.23600980
2drug transmembrane transport (GO:0006855)7.01204529
3tryptophan catabolic process (GO:0006569)6.61409807
4indole-containing compound catabolic process (GO:0042436)6.61409807
5indolalkylamine catabolic process (GO:0046218)6.61409807
6aminoglycoside antibiotic metabolic process (GO:0030647)6.42619025
7aromatic amino acid family catabolic process (GO:0009074)6.31384353
8tryptophan metabolic process (GO:0006568)6.21727154
9lysine catabolic process (GO:0006554)6.21215898
10lysine metabolic process (GO:0006553)6.21215898
11L-phenylalanine catabolic process (GO:0006559)5.90525196
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.90525196
13glyoxylate metabolic process (GO:0046487)5.87922656
14drug transport (GO:0015893)5.85691666
15behavioral response to nicotine (GO:0035095)5.70398035
16L-phenylalanine metabolic process (GO:0006558)5.70087825
17erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.70087825
18kynurenine metabolic process (GO:0070189)5.36070033
19organic cation transport (GO:0015695)5.18164254
20drug catabolic process (GO:0042737)5.15609717
21exogenous drug catabolic process (GO:0042738)5.05483800
22cysteine metabolic process (GO:0006534)5.04957570
23cellular biogenic amine catabolic process (GO:0042402)4.78677304
24amine catabolic process (GO:0009310)4.78677304
25fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.77732641
26indolalkylamine metabolic process (GO:0006586)4.75464310
27phosphate ion transport (GO:0006817)4.70620097
28aromatic amino acid family metabolic process (GO:0009072)4.56840430
29serine family amino acid catabolic process (GO:0009071)4.56118336
30amino-acid betaine metabolic process (GO:0006577)4.49973310
31short-chain fatty acid metabolic process (GO:0046459)4.36073474
32bile acid biosynthetic process (GO:0006699)4.35849932
33response to mercury ion (GO:0046689)4.34644079
34* homocysteine metabolic process (GO:0050667)4.30500008
35vitamin D metabolic process (GO:0042359)4.18908185
36phosphate ion transmembrane transport (GO:0035435)4.12182372
37alpha-amino acid catabolic process (GO:1901606)4.11801996
38cellular modified amino acid catabolic process (GO:0042219)4.05683599
39trivalent inorganic anion homeostasis (GO:0072506)4.04943341
40phosphate ion homeostasis (GO:0055062)4.04943341
41quaternary ammonium group transport (GO:0015697)3.99908640
42water-soluble vitamin biosynthetic process (GO:0042364)3.96015389
43indole-containing compound metabolic process (GO:0042430)3.92928254
44aspartate family amino acid catabolic process (GO:0009068)3.90064899
45valine metabolic process (GO:0006573)3.88562408
46branched-chain amino acid metabolic process (GO:0009081)3.87989037
47excretion (GO:0007588)3.87061166
48cellular amino acid catabolic process (GO:0009063)3.84838974
49serine family amino acid metabolic process (GO:0009069)3.77857907
50benzene-containing compound metabolic process (GO:0042537)3.77683880
51fructose metabolic process (GO:0006000)3.75701001
52NAD biosynthetic process (GO:0009435)3.75569849
53sulfur amino acid catabolic process (GO:0000098)3.72303804
54cellular glucuronidation (GO:0052695)3.70906867
55urea cycle (GO:0000050)3.67582907
56urea metabolic process (GO:0019627)3.67582907
57glucuronate metabolic process (GO:0019585)3.66115438
58uronic acid metabolic process (GO:0006063)3.66115438
59detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.66109101
60carnitine metabolic process (GO:0009437)3.65719229
61platelet dense granule organization (GO:0060155)3.65282660
62fatty acid beta-oxidation (GO:0006635)3.64945898
63cellular ketone body metabolic process (GO:0046950)3.63294879
64mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.62114633
65mitochondrial respiratory chain complex I assembly (GO:0032981)3.62114633
66NADH dehydrogenase complex assembly (GO:0010257)3.62114633
67branched-chain amino acid catabolic process (GO:0009083)3.60784647
68aldehyde catabolic process (GO:0046185)3.54509592
69glutamate metabolic process (GO:0006536)3.53313576
70acetyl-CoA metabolic process (GO:0006084)3.52597110
71coenzyme catabolic process (GO:0009109)3.50363631
722-oxoglutarate metabolic process (GO:0006103)3.50016855
73bile acid metabolic process (GO:0008206)3.49288418
74fatty acid oxidation (GO:0019395)3.48621468
75tyrosine metabolic process (GO:0006570)3.46964603
76pyridine nucleotide biosynthetic process (GO:0019363)3.45470090
77nicotinamide nucleotide biosynthetic process (GO:0019359)3.45470090
78renal absorption (GO:0070293)3.45199076
79lipid oxidation (GO:0034440)3.45063340
80carboxylic acid catabolic process (GO:0046395)3.44383661
81organic acid catabolic process (GO:0016054)3.44383661
82protein-cofactor linkage (GO:0018065)3.42974113
83epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.42170030
84detection of light stimulus involved in sensory perception (GO:0050962)3.39163469
85detection of light stimulus involved in visual perception (GO:0050908)3.39163469
86nitrogen cycle metabolic process (GO:0071941)3.38739559
87complement activation, alternative pathway (GO:0006957)3.38316940
88lymphangiogenesis (GO:0001946)3.32465239
89nonmotile primary cilium assembly (GO:0035058)3.30581632
90cullin deneddylation (GO:0010388)3.29585935
91regulation of protein activation cascade (GO:2000257)3.28812139
92regulation of bile acid biosynthetic process (GO:0070857)3.27932139
93dicarboxylic acid biosynthetic process (GO:0043650)3.26879188
94toxin transport (GO:1901998)3.22976475
95sulfation (GO:0051923)3.22190506
96metanephric tubule development (GO:0072170)3.21128185
97metanephric nephron tubule development (GO:0072234)3.21128185
98regulation of complement activation (GO:0030449)3.20765647
99fatty acid catabolic process (GO:0009062)3.20049381
100cellular response to ATP (GO:0071318)3.19963459
101monocarboxylic acid catabolic process (GO:0072329)3.19065077
102tricarboxylic acid metabolic process (GO:0072350)3.15736044
103protein complex biogenesis (GO:0070271)3.15666785
104proline metabolic process (GO:0006560)3.14989283
105gamma-aminobutyric acid transport (GO:0015812)3.12445407
106ethanol oxidation (GO:0006069)3.11725326
107ketone body metabolic process (GO:1902224)3.10113902
108response to phenylpropanoid (GO:0080184)3.09339897
109protein deneddylation (GO:0000338)3.08903520
110nonribosomal peptide biosynthetic process (GO:0019184)3.08060309
111cilium morphogenesis (GO:0060271)3.07867280
112polyol transport (GO:0015791)3.07216454
113amino-acid betaine transport (GO:0015838)3.06676241
114carnitine transport (GO:0015879)3.06676241
115somite development (GO:0061053)3.05040902
116serine family amino acid biosynthetic process (GO:0009070)3.04045713
117drug metabolic process (GO:0017144)3.00998820
118cell proliferation in forebrain (GO:0021846)3.00032116
119small molecule catabolic process (GO:0044282)2.99387623
120arginine metabolic process (GO:0006525)2.98480506
121peptidyl-glutamic acid carboxylation (GO:0017187)2.97901876
122protein carboxylation (GO:0018214)2.97901876
123photoreceptor cell maintenance (GO:0045494)2.97752123
124L-fucose catabolic process (GO:0042355)2.96120152
125fucose catabolic process (GO:0019317)2.96120152
126L-fucose metabolic process (GO:0042354)2.96120152
127mitochondrial respiratory chain complex assembly (GO:0033108)2.90342707
128inner ear receptor stereocilium organization (GO:0060122)2.87834731
129epithelial cilium movement (GO:0003351)2.87706352
130cornea development in camera-type eye (GO:0061303)2.83049682
131protein polyglutamylation (GO:0018095)2.82631273
132photoreceptor cell development (GO:0042461)2.81733215
133protein neddylation (GO:0045116)2.80057220
134negative regulation of transcription regulatory region DNA binding (GO:2000678)2.77038441
135reflex (GO:0060004)2.72872260
136DNA deamination (GO:0045006)2.69781159
137retinal ganglion cell axon guidance (GO:0031290)2.66643662
138response to pheromone (GO:0019236)2.63612915
139negative regulation of response to food (GO:0032096)2.62392294
140negative regulation of appetite (GO:0032099)2.62392294
141appendage development (GO:0048736)2.60681295
142limb development (GO:0060173)2.60681295
143protein K6-linked ubiquitination (GO:0085020)2.60294870
144negative regulation of systemic arterial blood pressure (GO:0003085)2.59886496
145intraciliary transport (GO:0042073)2.58900972
146auditory receptor cell stereocilium organization (GO:0060088)2.57906546
147pseudouridine synthesis (GO:0001522)2.57751903
148negative regulation of mast cell activation (GO:0033004)2.54468797
149regulation of hippo signaling (GO:0035330)2.53773901
150cilium or flagellum-dependent cell motility (GO:0001539)2.53549097
151visual perception (GO:0007601)2.52574299
152artery development (GO:0060840)2.51679506
153mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.51592711
154RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.50850984
155tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.50850984
156sensory perception of light stimulus (GO:0050953)2.50467275
157transmission of nerve impulse (GO:0019226)2.48172245
158primary amino compound metabolic process (GO:1901160)2.47617278
159negative regulation of synaptic transmission, GABAergic (GO:0032229)2.47368538
160behavioral response to ethanol (GO:0048149)2.46841818
161cilium organization (GO:0044782)2.46652497
162preassembly of GPI anchor in ER membrane (GO:0016254)2.46390273
163negative chemotaxis (GO:0050919)2.45705588
164retinal cone cell development (GO:0046549)2.45649196
165eye photoreceptor cell development (GO:0042462)2.43789153
166cAMP catabolic process (GO:0006198)2.43512180
167negative regulation of telomere maintenance (GO:0032205)2.43154679
168kidney morphogenesis (GO:0060993)2.41812481
169cilium assembly (GO:0042384)2.40355487
170detection of mechanical stimulus involved in sensory perception (GO:0050974)2.39984038
171mannosylation (GO:0097502)2.38606615
172neuronal action potential (GO:0019228)2.38270873
173G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.38138866
174positive regulation of oligodendrocyte differentiation (GO:0048714)2.38091666
175regulation of cilium movement (GO:0003352)2.35826621
176smoothened signaling pathway (GO:0007224)2.35819721
177positive regulation of fatty acid oxidation (GO:0046321)2.35655440
178nephron tubule morphogenesis (GO:0072078)2.35179999
179nephron epithelium morphogenesis (GO:0072088)2.35179999
180limb bud formation (GO:0060174)2.34913465
181regulation of rhodopsin mediated signaling pathway (GO:0022400)2.34550098
182retina development in camera-type eye (GO:0060041)2.33570261
183multicellular organism reproduction (GO:0032504)2.32749096
184startle response (GO:0001964)2.32368123
185regulation of glomerulus development (GO:0090192)2.30934412
186L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.30377609
187outer ear morphogenesis (GO:0042473)2.30245196
188regulation of mesoderm development (GO:2000380)2.30133782
189cardiovascular system development (GO:0072358)2.29965944
190rhodopsin mediated signaling pathway (GO:0016056)2.29780767
191respiratory chain complex IV assembly (GO:0008535)2.28965436

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.47511957
2EGR1_23403033_ChIP-Seq_LIVER_Mouse4.29137625
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.20609921
4LXR_22158963_ChIP-Seq_LIVER_Mouse3.39182849
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.38122977
6ZNF274_21170338_ChIP-Seq_K562_Hela3.34685422
7EZH2_22144423_ChIP-Seq_EOC_Human3.20531309
8GBX2_23144817_ChIP-Seq_PC3_Human2.81614084
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.62719667
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.49938435
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.46245195
12IGF1R_20145208_ChIP-Seq_DFB_Human2.39220160
13EWS_26573619_Chip-Seq_HEK293_Human2.30973454
14FUS_26573619_Chip-Seq_HEK293_Human2.24094628
15SUZ12_27294783_Chip-Seq_NPCs_Mouse2.01498836
16FLI1_27457419_Chip-Seq_LIVER_Mouse1.92174802
17ZFP57_27257070_Chip-Seq_ESCs_Mouse1.90822716
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.90454194
19PCGF2_27294783_Chip-Seq_ESCs_Mouse1.88730703
20CTBP1_25329375_ChIP-Seq_LNCAP_Human1.86594421
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.85667165
22NFE2_27457419_Chip-Seq_LIVER_Mouse1.85518429
23PIAS1_25552417_ChIP-Seq_VCAP_Human1.83566879
24PCGF2_27294783_Chip-Seq_NPCs_Mouse1.82856042
25ESR1_21235772_ChIP-Seq_MCF-7_Human1.80615445
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.80018521
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.79468900
28CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.78159389
29EZH2_27294783_Chip-Seq_NPCs_Mouse1.73155302
30PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.71437156
31CBX2_27304074_Chip-Seq_ESCs_Mouse1.70731594
32MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.69290400
33TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.61489573
34IRF1_19129219_ChIP-ChIP_H3396_Human1.60647739
35EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.59425040
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.58038852
37PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.52883839
38CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.52290720
39RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50244536
40PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.47988394
41SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47649966
42EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.46655040
43CBP_20019798_ChIP-Seq_JUKART_Human1.46625311
44IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46625311
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.46377427
46TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46055084
47STAT3_23295773_ChIP-Seq_U87_Human1.45835947
48NR3C1_21868756_ChIP-Seq_MCF10A_Human1.45175834
49GABP_17652178_ChIP-ChIP_JURKAT_Human1.43089756
50P53_22387025_ChIP-Seq_ESCs_Mouse1.41120438
51CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.39245602
52SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37901092
53TCF4_23295773_ChIP-Seq_U87_Human1.37747569
54E2F1_18555785_Chip-Seq_ESCs_Mouse1.37530512
55CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.37403219
56RNF2_27304074_Chip-Seq_NSC_Mouse1.35729995
57SUZ12_18555785_Chip-Seq_ESCs_Mouse1.35335921
58STAT3_18555785_Chip-Seq_ESCs_Mouse1.35058443
59OCT4_18555785_Chip-Seq_ESCs_Mouse1.34778239
60P300_19829295_ChIP-Seq_ESCs_Human1.34559850
61TRIM28_21343339_ChIP-Seq_HEK293_Human1.34252842
62AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.33606793
63E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.33165586
64HTT_18923047_ChIP-ChIP_STHdh_Human1.32729319
65TCF4_22108803_ChIP-Seq_LS180_Human1.32550758
66EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.32529941
67MYC_18940864_ChIP-ChIP_HL60_Human1.32115037
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.32046869
69* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31789708
70NANOG_18555785_Chip-Seq_ESCs_Mouse1.31574195
71SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.30829846
72CRX_20693478_ChIP-Seq_RETINA_Mouse1.30362845
73TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30212205
74NOTCH1_21737748_ChIP-Seq_TLL_Human1.30030879
75NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.29817787
76TP53_16413492_ChIP-PET_HCT116_Human1.29773718
77RUNX1_27457419_Chip-Seq_LIVER_Mouse1.29306273
78STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.28856062
79TP53_22573176_ChIP-Seq_HFKS_Human1.28415522
80AR_25329375_ChIP-Seq_VCAP_Human1.27202893
81POU5F1_16153702_ChIP-ChIP_HESCs_Human1.27202614
82Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.27134920
83MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27021984
84OCT4_21477851_ChIP-Seq_ESCs_Mouse1.26669765
85POU3F2_20337985_ChIP-ChIP_501MEL_Human1.25690892
86CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.25115130
87NMYC_18555785_Chip-Seq_ESCs_Mouse1.24725729
88OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24157257
89P300_18555785_Chip-Seq_ESCs_Mouse1.23677632
90ESRRB_18555785_Chip-Seq_ESCs_Mouse1.23380133
91RUNX2_22187159_ChIP-Seq_PCA_Human1.23161453
92FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.22717719
93SOX2_18555785_Chip-Seq_ESCs_Mouse1.21740619
94EZH2_27304074_Chip-Seq_ESCs_Mouse1.21362032
95ZFX_18555785_Chip-Seq_ESCs_Mouse1.20136976
96PU1_27457419_Chip-Seq_LIVER_Mouse1.19504802
97NRF2_20460467_ChIP-Seq_MEFs_Mouse1.19467552
98NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.19467552
99SOX2_19829295_ChIP-Seq_ESCs_Human1.19265079
100NANOG_19829295_ChIP-Seq_ESCs_Human1.19265079
101FLI1_21867929_ChIP-Seq_TH2_Mouse1.19202819
102CMYC_18555785_Chip-Seq_ESCs_Mouse1.19189096
103FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.19127573
104TAF15_26573619_Chip-Seq_HEK293_Human1.18688213
105KLF4_18555785_Chip-Seq_ESCs_Mouse1.17202784
106GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16636416
107TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.16608829
108ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.16605031
109SMAD1_18555785_Chip-Seq_ESCs_Mouse1.16337370
110KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15854444
111SMAD4_21799915_ChIP-Seq_A2780_Human1.15481330
112BMI1_23680149_ChIP-Seq_NPCS_Mouse1.14389884
113CDX2_20551321_ChIP-Seq_CACO-2_Human1.13778150
114TP53_18474530_ChIP-ChIP_U2OS_Human1.13495896
115PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.13391977
116CTCF_18555785_Chip-Seq_ESCs_Mouse1.12972124
117EED_16625203_ChIP-ChIP_MESCs_Mouse1.12734204
118JUN_21703547_ChIP-Seq_K562_Human1.12523467
119SMAD4_21741376_ChIP-Seq_EPCs_Human1.12422739
120JARID2_20064375_ChIP-Seq_MESCs_Mouse1.12387223
121VDR_22108803_ChIP-Seq_LS180_Human1.11688778
122TAL1_26923725_Chip-Seq_HPCs_Mouse1.11150042
123STAT1_17558387_ChIP-Seq_HELA_Human1.11084255
124IRF8_22096565_ChIP-ChIP_GC-B_Human1.09959697
125SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.07464246
126FOXA1_25329375_ChIP-Seq_VCAP_Human1.07354898
127FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07354898
128RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.06412225
129TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06255088
130POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06255088
131HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.06240426
132ELK1_19687146_ChIP-ChIP_HELA_Human1.06158707
133* KAP1_22055183_ChIP-Seq_ESCs_Mouse1.04618771
134SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.04510164
135FOXA2_19822575_ChIP-Seq_HepG2_Human1.03846067
136KDM2B_26808549_Chip-Seq_REH_Human1.03386153
137AUTS2_25519132_ChIP-Seq_293T-REX_Human1.03169689
138KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.03135479
139CJUN_26792858_Chip-Seq_BT549_Human1.02678634
140PRDM14_20953172_ChIP-Seq_ESCs_Human1.02675102
141ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01593259
142EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01414300
143ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00749475
144TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.00524771
145BCAT_22108803_ChIP-Seq_LS180_Human0.99827266
146HNF4A_19822575_ChIP-Seq_HepG2_Human0.98803292
147EST1_17652178_ChIP-ChIP_JURKAT_Human0.98685437
148MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97537471
149CDX2_22108803_ChIP-Seq_LS180_Human0.97151735
150ER_23166858_ChIP-Seq_MCF-7_Human0.97148118
151CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.96870926
152UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96656974
153SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.96612067
154SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.93562121
155BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93220233
156* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.92809883
157ARNT_22903824_ChIP-Seq_MCF-7_Human0.92721862
158TOP2B_26459242_ChIP-Seq_MCF-7_Human0.90474879
159CTBP2_25329375_ChIP-Seq_LNCAP_Human0.88987035
160SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.88405736

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.94824632
2MP0002139_abnormal_hepatobiliary_system6.32503645
3MP0005085_abnormal_gallbladder_physiolo4.60840076
4MP0004019_abnormal_vitamin_homeostasis4.38753732
5MP0005365_abnormal_bile_salt4.37350962
6MP0003195_calcinosis4.31828603
7MP0003252_abnormal_bile_duct4.05086855
8MP0002138_abnormal_hepatobiliary_system4.04568366
9MP0005332_abnormal_amino_acid3.89881789
10MP0008875_abnormal_xenobiotic_pharmacok3.61090396
11MP0004043_abnormal_pH_regulation3.36455653
12MP0002102_abnormal_ear_morphology3.29313524
13MP0009643_abnormal_urine_homeostasis2.66063040
14MP0005551_abnormal_eye_electrophysiolog2.57616872
15MP0003646_muscle_fatigue2.20039220
16MP0006072_abnormal_retinal_apoptosis2.19848775
17MP0001765_abnormal_ion_homeostasis2.18394827
18MP0001958_emphysema2.18134408
19MP0003136_yellow_coat_color2.13074990
20MP0005253_abnormal_eye_physiology2.11637328
21MP0005636_abnormal_mineral_homeostasis2.11631489
22MP0002876_abnormal_thyroid_physiology2.04828005
23MP0004133_heterotaxia2.02428073
24MP0005451_abnormal_body_composition1.96990399
25MP0001756_abnormal_urination1.94048685
26MP0006292_abnormal_olfactory_placode1.89179207
27* MP0002136_abnormal_kidney_physiology1.88972802
28MP0000049_abnormal_middle_ear1.85886319
29MP0002837_dystrophic_cardiac_calcinosis1.82596010
30MP0010329_abnormal_lipoprotein_level1.81328606
31MP0004145_abnormal_muscle_electrophysio1.81179822
32MP0003283_abnormal_digestive_organ1.80685846
33MP0008877_abnormal_DNA_methylation1.80538493
34MP0004142_abnormal_muscle_tone1.76719410
35MP0003806_abnormal_nucleotide_metabolis1.76687208
36MP0002638_abnormal_pupillary_reflex1.75633161
37MP0001485_abnormal_pinna_reflex1.74215808
38MP0009046_muscle_twitch1.72352402
39MP0002938_white_spotting1.65885276
40MP0001968_abnormal_touch/_nociception1.64174744
41MP0005670_abnormal_white_adipose1.62947703
42MP0009250_abnormal_appendicular_skeleto1.62528528
43MP0002736_abnormal_nociception_after1.57325544
44MP0002653_abnormal_ependyma_morphology1.54580360
45MP0001764_abnormal_homeostasis1.54086451
46MP0001666_abnormal_nutrient_absorption1.53752566
47MP0006276_abnormal_autonomic_nervous1.52146883
48MP0002928_abnormal_bile_duct1.51113966
49MP0000538_abnormal_urinary_bladder1.49918861
50MP0000631_abnormal_neuroendocrine_gland1.49400060
51MP0010030_abnormal_orbit_morphology1.46908369
52MP0000372_irregular_coat_pigmentation1.46130721
53MP0005084_abnormal_gallbladder_morpholo1.45045060
54MP0005319_abnormal_enzyme/_coenzyme1.43198610
55MP0009697_abnormal_copulation1.42401214
56MP0004215_abnormal_myocardial_fiber1.37753705
57MP0001986_abnormal_taste_sensitivity1.35483476
58MP0002272_abnormal_nervous_system1.35275367
59MP0005584_abnormal_enzyme/coenzyme_acti1.34052119
60MP0005195_abnormal_posterior_eye1.34038504
61MP0008872_abnormal_physiological_respon1.32558628
62MP0003191_abnormal_cellular_cholesterol1.32392479
63MP0003868_abnormal_feces_composition1.30649348
64MP0003937_abnormal_limbs/digits/tail_de1.30285521
65MP0009745_abnormal_behavioral_response1.29201205
66MP0005167_abnormal_blood-brain_barrier1.28439312
67MP0005083_abnormal_biliary_tract1.28116191
68MP0002168_other_aberrant_phenotype1.28076176
69MP0005503_abnormal_tendon_morphology1.27614715
70MP0002163_abnormal_gland_morphology1.25697065
71MP0004134_abnormal_chest_morphology1.25418621
72MP0005377_hearing/vestibular/ear_phenot1.25388240
73MP0003878_abnormal_ear_physiology1.25388240
74MP0004782_abnormal_surfactant_physiolog1.25037468
75MP0003724_increased_susceptibility_to1.24988567
76MP0002118_abnormal_lipid_homeostasis1.23900699
77MP0003880_abnormal_central_pattern1.23566937
78MP0008775_abnormal_heart_ventricle1.23113396
79MP0001486_abnormal_startle_reflex1.21828104
80* MP0009764_decreased_sensitivity_to1.21526730
81MP0000778_abnormal_nervous_system1.19789483
82MP0001529_abnormal_vocalization1.19233003
83MP0003787_abnormal_imprinting1.18910705
84* MP0003186_abnormal_redox_activity1.14107896
85MP0002282_abnormal_trachea_morphology1.13841087
86MP0000427_abnormal_hair_cycle1.13261553
87MP0004742_abnormal_vestibular_system1.09842597
88MP0002752_abnormal_somatic_nervous1.09451186
89MP0001293_anophthalmia1.08959302
90MP0006054_spinal_hemorrhage1.07691893
91MP0005389_reproductive_system_phenotype1.03795040
92MP0002160_abnormal_reproductive_system1.03213450
93MP0000609_abnormal_liver_physiology1.02931422
94MP0005187_abnormal_penis_morphology1.00813483
95MP0000230_abnormal_systemic_arterial1.00513613
96MP0008789_abnormal_olfactory_epithelium0.99110503
97MP0005391_vision/eye_phenotype0.98988287
98MP0002751_abnormal_autonomic_nervous0.98781572
99MP0005647_abnormal_sex_gland0.98749544
100MP0002557_abnormal_social/conspecific_i0.96972453
101MP0003119_abnormal_digestive_system0.96821845
102MP0003755_abnormal_palate_morphology0.96751289
103MP0003011_delayed_dark_adaptation0.96353549
104MP0003122_maternal_imprinting0.95189962
105MP0008438_abnormal_cutaneous_collagen0.93942178
106MP0010368_abnormal_lymphatic_system0.93776258
107MP0001502_abnormal_circadian_rhythm0.91597671
108MP0002233_abnormal_nose_morphology0.90748709
109MP0001324_abnormal_eye_pigmentation0.89429655
110MP0000647_abnormal_sebaceous_gland0.89267698
111MP0009384_cardiac_valve_regurgitation0.88833640
112MP0004272_abnormal_basement_membrane0.88280461
113MP0002734_abnormal_mechanical_nocicepti0.87577866
114MP0001963_abnormal_hearing_physiology0.87335711
115MP0005220_abnormal_exocrine_pancreas0.86425408
116MP0002572_abnormal_emotion/affect_behav0.85445339
117MP0005379_endocrine/exocrine_gland_phen0.84968297
118MP0001970_abnormal_pain_threshold0.84319393
119MP0005535_abnormal_body_temperature0.83946180
120MP0001984_abnormal_olfaction0.83740655
121MP0004085_abnormal_heartbeat0.83735275
122MP0010386_abnormal_urinary_bladder0.82670491
123MP0003121_genomic_imprinting0.82264255
124MP0002733_abnormal_thermal_nociception0.81593613
125MP0001501_abnormal_sleep_pattern0.81026635
126MP0002067_abnormal_sensory_capabilities0.80340714
127MP0005508_abnormal_skeleton_morphology0.79501500
128MP0002064_seizures0.79439763
129MP0002135_abnormal_kidney_morphology0.77822688
130MP0008469_abnormal_protein_level0.77788229
131MP0005386_behavior/neurological_phenoty0.77419388
132MP0004924_abnormal_behavior0.77419388
133MP0009642_abnormal_blood_homeostasis0.77411742
134MP0002184_abnormal_innervation0.77272226
135MP0005395_other_phenotype0.77198702
136MP0002735_abnormal_chemical_nociception0.76630636
137MP0001286_abnormal_eye_development0.76238917
138MP0004147_increased_porphyrin_level0.73317745
139MP0001177_atelectasis0.69996375
140MP0005408_hypopigmentation0.67359036
141MP0005058_abnormal_lysosome_morphology0.66129085
142MP0005646_abnormal_pituitary_gland0.64875679
143MP0001661_extended_life_span0.64751486
144MP0002896_abnormal_bone_mineralization0.63151848
145MP0000566_synostosis0.61952603
146MP0002108_abnormal_muscle_morphology0.60461416
147MP0005257_abnormal_intraocular_pressure0.58816836
148MP0005595_abnormal_vascular_smooth0.56612852
149MP0000678_abnormal_parathyroid_gland0.55507892
150MP0000598_abnormal_liver_morphology0.55477961
151MP0000579_abnormal_nail_morphology0.55128762
152MP0002998_abnormal_bone_remodeling0.52374416
153MP0002115_abnormal_skeleton_extremities0.50452113
154MP0003941_abnormal_skin_development0.50014162
155MP0002295_abnormal_pulmonary_circulatio0.49989111
156MP0009763_increased_sensitivity_to0.49566261
157MP0000163_abnormal_cartilage_morphology0.48900498
158MP0005275_abnormal_skin_tensile0.48642573
159MP0003638_abnormal_response/metabolism_0.47484822
160MP0001542_abnormal_bone_strength0.47296732
161MP0000383_abnormal_hair_follicle0.46299680
162MP0001879_abnormal_lymphatic_vessel0.45732938
163MP0002098_abnormal_vibrissa_morphology0.45138983
164MP0006082_CNS_inflammation0.43964297
165MP0001188_hyperpigmentation0.43472744
166MP0004885_abnormal_endolymph0.42958252
167MP0002060_abnormal_skin_morphology0.42699371
168MP0008961_abnormal_basal_metabolism0.41991122
169MP0005376_homeostasis/metabolism_phenot0.39933635
170MP0002078_abnormal_glucose_homeostasis0.39440334
171MP0003300_gastrointestinal_ulcer0.39207459
172MP0005171_absent_coat_pigmentation0.38743408
173MP0002254_reproductive_system_inflammat0.38674087
174MP0003959_abnormal_lean_body0.38585048
175MP0000026_abnormal_inner_ear0.38575330
176MP0002132_abnormal_respiratory_system0.38461475
177MP0005334_abnormal_fat_pad0.37880585
178MP0003953_abnormal_hormone_level0.37876822
179MP0005666_abnormal_adipose_tissue0.37473458
180MP0009765_abnormal_xenobiotic_induced0.36319547
181MP0005248_abnormal_Harderian_gland0.35816822

Predicted human phenotypes

RankGene SetZ-score
1Increased circulating renin level (HP:0000848)5.90986680
2Hyperactive renin-angiotensin system (HP:0000841)5.70199169
3Metabolic alkalosis (HP:0200114)5.48919996
4Hypokalemic alkalosis (HP:0001949)5.45680504
5Hypomagnesemia (HP:0002917)5.36735443
6Abnormality of glutamine family amino acid metabolism (HP:0010902)5.28360618
7Gout (HP:0001997)5.15720638
8Polyuria (HP:0000103)4.99527794
9Abnormality of chloride homeostasis (HP:0011422)4.85987568
10Proximal tubulopathy (HP:0000114)4.82349979
11Abnormal urine output (HP:0012590)4.76042459
12Hyperglycinuria (HP:0003108)4.60439263
13Abnormality of renal excretion (HP:0011036)4.55787921
14Pancreatic cysts (HP:0001737)4.54282448
15Pancreatic fibrosis (HP:0100732)4.52608916
16Tetany (HP:0001281)4.41424080
17Alkalosis (HP:0001948)4.36424009
18Abnormality of magnesium homeostasis (HP:0004921)4.33549509
19Molar tooth sign on MRI (HP:0002419)4.22897074
20Abnormality of midbrain morphology (HP:0002418)4.22897074
21True hermaphroditism (HP:0010459)4.21890880
22Polydipsia (HP:0001959)4.00910492
23Abnormal drinking behavior (HP:0030082)4.00910492
24Abnormality of purine metabolism (HP:0004352)3.99681912
25Hyperuricemia (HP:0002149)3.93929957
26Increased purine levels (HP:0004368)3.93929957
27Abnormality of aromatic amino acid family metabolism (HP:0004338)3.90789153
28Abnormality of renin-angiotensin system (HP:0000847)3.90598667
29Abnormality of serine family amino acid metabolism (HP:0010894)3.88948005
30Abnormality of glycine metabolism (HP:0010895)3.88948005
31Increased corneal curvature (HP:0100692)3.87907125
32Keratoconus (HP:0000563)3.87907125
33Hyperaldosteronism (HP:0000859)3.84572925
34Congenital stationary night blindness (HP:0007642)3.81571089
35Intrahepatic cholestasis (HP:0001406)3.77395737
36Abnormality of aspartate family amino acid metabolism (HP:0010899)3.77002429
37Pendular nystagmus (HP:0012043)3.76789334
38Generalized aminoaciduria (HP:0002909)3.67108607
39Abnormality of nucleobase metabolism (HP:0010932)3.57532120
40Hydroxyprolinuria (HP:0003080)3.45765000
41Abnormality of proline metabolism (HP:0010907)3.45765000
42Nephronophthisis (HP:0000090)3.42710071
43Hyperglycinemia (HP:0002154)3.36045394
44Renal salt wasting (HP:0000127)3.34816357
45Vascular calcification (HP:0004934)3.34602234
46Renal tubular acidosis (HP:0001947)3.27679608
47Abolished electroretinogram (ERG) (HP:0000550)3.27330084
48Ketosis (HP:0001946)3.27169641
49Aplasia/Hypoplasia of the tibia (HP:0005772)3.20321897
50Cardiovascular calcification (HP:0011915)3.18468378
51Abnormality of monocarboxylic acid metabolism (HP:0010996)3.14967008
52Ketoacidosis (HP:0001993)3.13998979
53Abnormality of the renal medulla (HP:0100957)3.06174140
54Enlarged kidneys (HP:0000105)3.03305332
55Xanthomatosis (HP:0000991)3.02364150
56Abnormality of fatty-acid metabolism (HP:0004359)3.00952346
57Chronic hepatic failure (HP:0100626)2.98953261
58Abnormality of sulfur amino acid metabolism (HP:0004339)2.98917689
59Hyperammonemia (HP:0001987)2.97458491
60Glycosuria (HP:0003076)2.96113585
61Abnormality of urine glucose concentration (HP:0011016)2.96113585
62Short tibia (HP:0005736)2.92289831
63Hypokalemia (HP:0002900)2.92118396
64Chorioretinal atrophy (HP:0000533)2.91773296
65Hypercalciuria (HP:0002150)2.90797823
66Conjugated hyperbilirubinemia (HP:0002908)2.87579715
67Cystic liver disease (HP:0006706)2.83894055
68Joint hemorrhage (HP:0005261)2.78201063
69Medial flaring of the eyebrow (HP:0010747)2.77646635
70Delayed CNS myelination (HP:0002188)2.77206691
71Rickets (HP:0002748)2.74008082
72Abnormality of pyrimidine metabolism (HP:0004353)2.73232535
73Prolonged partial thromboplastin time (HP:0003645)2.69368145
74Aplasia/Hypoplasia of the tongue (HP:0010295)2.66593466
75Abnormal rod and cone electroretinograms (HP:0008323)2.62066506
76Deep venous thrombosis (HP:0002625)2.59201769
77Type II lissencephaly (HP:0007260)2.58884930
78Widely patent fontanelles and sutures (HP:0004492)2.58352931
79Attenuation of retinal blood vessels (HP:0007843)2.57699881
80Abnormality of potassium homeostasis (HP:0011042)2.56810299
81Acute necrotizing encephalopathy (HP:0006965)2.56480042
82Absent rod-and cone-mediated responses on ERG (HP:0007688)2.55173306
83Tubular atrophy (HP:0000092)2.53342136
84Decreased central vision (HP:0007663)2.53286595
85Nephrocalcinosis (HP:0000121)2.50701793
86Metabolic acidosis (HP:0001942)2.50265658
87Alveolar cell carcinoma (HP:0006519)2.49115417
88Complement deficiency (HP:0004431)2.49105527
89Abnormality of serum amino acid levels (HP:0003112)2.47404794
90Renal cortical cysts (HP:0000803)2.47342922
91Hypophosphatemia (HP:0002148)2.43209931
92Sclerocornea (HP:0000647)2.42748797
93Nephrolithiasis (HP:0000787)2.42165086
94Congenital hepatic fibrosis (HP:0002612)2.38113586
95Congenital sensorineural hearing impairment (HP:0008527)2.37557364
96Hepatocellular carcinoma (HP:0001402)2.37438711
97Dicarboxylic aciduria (HP:0003215)2.37348112
98Abnormality of dicarboxylic acid metabolism (HP:0010995)2.37348112
99Hypophosphatemic rickets (HP:0004912)2.36693285
100Acute encephalopathy (HP:0006846)2.36360061
101Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.35857641
102Abnormality of alanine metabolism (HP:0010916)2.35857641
103Hyperalaninemia (HP:0003348)2.35857641
104Abnormality of the phalanges of the 2nd finger (HP:0009541)2.35709240
105Abnormal number of erythroid precursors (HP:0012131)2.32357070
106Neoplasm of the tracheobronchial system (HP:0100552)2.32068772
107Postaxial foot polydactyly (HP:0001830)2.28619151
108Abnormality of the renal cortex (HP:0011035)2.26857351
109Anencephaly (HP:0002323)2.25056752
110Abnormality of methionine metabolism (HP:0010901)2.24751138
111Fat malabsorption (HP:0002630)2.23687736
112Bony spicule pigmentary retinopathy (HP:0007737)2.23547741
113Progressive macrocephaly (HP:0004481)2.22903974
1143-Methylglutaconic aciduria (HP:0003535)2.22211087
115Vomiting (HP:0002013)2.21993771
116Lethargy (HP:0001254)2.21370278
117Abnormal enzyme/coenzyme activity (HP:0012379)2.18682139
118Abnormal urine phosphate concentration (HP:0012599)2.18538772
119Optic nerve hypoplasia (HP:0000609)2.17975041
120Mitochondrial inheritance (HP:0001427)2.16335060
121Hypoglycemic coma (HP:0001325)2.15536964
122Congenital primary aphakia (HP:0007707)2.15089063
123Gait imbalance (HP:0002141)2.15060128
124Decreased electroretinogram (ERG) amplitude (HP:0000654)2.13784973
125Methylmalonic acidemia (HP:0002912)2.13593281
126Congenital, generalized hypertrichosis (HP:0004540)2.13055202
127Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.12213112
128Epidermoid cyst (HP:0200040)2.12138071
129Abnormal mitochondria in muscle tissue (HP:0008316)2.11982807
130Bile duct proliferation (HP:0001408)2.11752505
131Abnormal biliary tract physiology (HP:0012439)2.11752505
132Hyperphosphaturia (HP:0003109)2.11026040
133Methylmalonic aciduria (HP:0012120)2.10735518
134Furrowed tongue (HP:0000221)2.06647847
135Renal tubular dysfunction (HP:0000124)2.06508025
136Occipital encephalocele (HP:0002085)2.06464999
137Dehydration (HP:0001944)2.06103936
138Vacuolated lymphocytes (HP:0001922)2.05678343
139Abnormality of alkaline phosphatase activity (HP:0004379)2.05277670
140Stenosis of the external auditory canal (HP:0000402)2.05039789
141Genital tract atresia (HP:0001827)2.04113799
142Fibular hypoplasia (HP:0003038)2.03472516
143Male pseudohermaphroditism (HP:0000037)2.02797701
144Confusion (HP:0001289)2.02491865
145Potter facies (HP:0002009)2.02351888
146Facial shape deformation (HP:0011334)2.02351888
147Genetic anticipation (HP:0003743)2.02022030
148Increased CSF lactate (HP:0002490)2.01800497
149Postaxial hand polydactyly (HP:0001162)2.01255366
150Hyperventilation (HP:0002883)1.99201033
151Abnormal respiratory motile cilium morphology (HP:0005938)1.98820316
152Abnormal respiratory epithelium morphology (HP:0012253)1.98820316
153Aplasia/Hypoplasia of the spleen (HP:0010451)1.98187361
154Abnormality of cells of the erythroid lineage (HP:0012130)1.98105574
155Preaxial hand polydactyly (HP:0001177)1.96650532
156Delayed epiphyseal ossification (HP:0002663)1.95700578
157Small hand (HP:0200055)1.94528912
158Fair hair (HP:0002286)1.92544376
159Systemic lupus erythematosus (HP:0002725)1.92030559
160Absent/shortened dynein arms (HP:0200106)1.91963682
161Dynein arm defect of respiratory motile cilia (HP:0012255)1.91963682
162Nephrogenic diabetes insipidus (HP:0009806)1.91862647
163Vaginal atresia (HP:0000148)1.91735481
164Elevated alkaline phosphatase (HP:0003155)1.91263724
165Mitral stenosis (HP:0001718)1.90841590
166Nausea (HP:0002018)1.90033995
167Tubulointerstitial fibrosis (HP:0005576)1.89510221
168Aplasia/Hypoplasia of the fibula (HP:0006492)1.88673989
169Progressive cerebellar ataxia (HP:0002073)1.88188226
170Metaphyseal irregularity (HP:0003025)1.87553285
171Asplenia (HP:0001746)1.87414402
172Abnormality of Sharpey fibers (HP:0100685)1.86279297
173Aplasia/Hypoplasia of the uvula (HP:0010293)1.82154449
174Optic disc pallor (HP:0000543)1.80385278
175Malnutrition (HP:0004395)1.79636127
176Rib fusion (HP:0000902)1.78261611
177Chondrocalcinosis (HP:0000934)1.78104577
178Abnormality of renal resorption (HP:0011038)1.76910250
179Hemiparesis (HP:0001269)1.74537417
180Inability to walk (HP:0002540)1.72944720
181Hepatocellular necrosis (HP:0001404)1.72359080
182Dandy-Walker malformation (HP:0001305)1.72098821
183Broad-based gait (HP:0002136)1.71909742
184Narrow forehead (HP:0000341)1.71907901
185Median cleft lip (HP:0000161)1.71110985
186Abnormality of the renal collecting system (HP:0004742)1.70166140
187Short 4th metacarpal (HP:0010044)1.66651608
188Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.66651608
189Cerebellar dysplasia (HP:0007033)1.65001667
190Gaze-evoked nystagmus (HP:0000640)1.64816447
191Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.64122991
192Abnormality of the phalanges of the 5th finger (HP:0004213)1.64118482
193Large for gestational age (HP:0001520)1.63817718

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK35.79838956
2WNK45.60258087
3OXSR15.23086903
4STK38L3.91824366
5BMPR1B2.93338441
6MAP4K22.79790941
7BCKDK2.61445599
8STK392.56591025
9INSRR2.44376737
10IRAK32.09398642
11MAP3K142.00268109
12CASK1.90580920
13LATS11.90188273
14TLK11.85952406
15MAP3K41.77326406
16SGK21.75819126
17SGK4941.72962906
18SGK2231.72962906
19PINK11.70626613
20TIE11.68953437
21MST1R1.63613295
22EPHA31.58510818
23TGFBR21.58092434
24FRK1.56305344
25FGFR41.52296886
26TGFBR11.50837477
27STK161.45881508
28ZAK1.45439365
29EIF2AK21.45188278
30ERBB41.39954667
31PAK31.31900509
32DYRK21.29150326
33PIK3CG1.28459604
34NUAK11.28418122
35TXK1.27038527
36SGK31.25441926
37PLK21.17775442
38TAOK31.13604014
39TNIK1.11843904
40IRAK11.09142966
41NTRK31.08708521
42PTK2B1.05267065
43GRK11.04814348
44ADRBK11.01838989
45MAPK130.99079225
46EPHA40.97487504
47CSNK1G10.95608220
48FGFR20.93720089
49WNK10.93047568
50MKNK20.92562370
51PRKAA20.91590948
52MARK10.89541233
53STK30.88840494
54DYRK30.88778466
55ACVR1B0.88192302
56MAPK110.86555273
57NEK90.81644104
58CSNK1G30.77100782
59CSNK1G20.76758619
60SIK10.76749441
61NME10.76636668
62AKT30.76559460
63JAK10.75949766
64PNCK0.74392090
65IRAK20.74010576
66FLT30.73817924
67STK380.73533702
68ADRBK20.73007476
69STK240.71855226
70PRKCG0.70764468
71VRK10.69765498
72PDK20.67273546
73IRAK40.67178489
74CAMKK20.67036166
75CSNK1A1L0.66837510
76PLK30.66111120
77BMPR20.65423537
78MAP3K70.64012895
79PDK40.63567471
80PDK30.63567471
81SGK10.63531895
82KDR0.63190289
83NTRK20.62798226
84PRKAA10.61945077
85MAP2K70.61742655
86TAF10.59716162
87LIMK10.57710666
88CAMK2A0.55837835
89TEC0.55714270
90YES10.55450909
91MAP3K30.55156701
92PRPF4B0.54887795
93EPHB20.54593719
94RPS6KA50.53996778
95TAOK20.53391871
96TRIM280.53285182
97CDC70.53093654
98GSK3A0.52361593
99MUSK0.51902920
100TRPM70.51399069
101EIF2AK30.50701231
102PRKCE0.50370513
103IKBKE0.50333216
104CAMK10.49982192
105PKN10.49887661
106CHEK20.49298991
107CSNK1A10.48933343
108PLK40.47644821
109PRKD20.47412707
110ERBB20.47091160
111PBK0.47090499
112ABL20.46429476
113MYLK0.46036313
114RPS6KA40.45831497
115ERBB30.45236151
116CAMK1D0.45192814
117PIK3CA0.44715911
118PLK10.44658307
119WEE10.43230965
120ERN10.42842356
121BUB10.42170194
122CHUK0.42065154
123BRSK20.41840183
124CAMK2D0.40866579
125NLK0.38019948
126DYRK1A0.37508085
127CLK10.37247306
128VRK20.37240816
129SIK30.36945468
130EPHA20.36643701
131PRKCD0.36611553
132TBK10.36189196
133NEK60.36127254
134CDK80.36047578
135PRKCZ0.35689879
136IKBKB0.35094115
137FER0.35024000
138MAPK150.34858194
139MST40.34817232
140MAPK70.34014942
141IGF1R0.32647691
142AKT20.31583044
143CDK30.31122043
144PRKACG0.31024353
145MAP2K60.30821952
146JAK30.30538013
147TYK20.30448903
148PRKCQ0.29758719
149GRK70.29686521
150MKNK10.29453167
151PRKCA0.29234782
152BCR0.29163106
153MET0.29139893
154PRKCH0.28570600
155RIPK10.28218667
156PRKACA0.27456897
157DAPK20.26881020
158OBSCN0.26313459
159MAP2K40.26229596

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.48405311
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.26429923
3Pentose and glucuronate interconversions_Homo sapiens_hsa000403.02517196
4Tryptophan metabolism_Homo sapiens_hsa003802.92913618
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.88218895
6Butanoate metabolism_Homo sapiens_hsa006502.84652123
7Propanoate metabolism_Homo sapiens_hsa006402.76980597
8Phototransduction_Homo sapiens_hsa047442.75997374
9Fatty acid degradation_Homo sapiens_hsa000712.60477820
10Peroxisome_Homo sapiens_hsa041462.60406400
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.55837744
12Oxidative phosphorylation_Homo sapiens_hsa001902.47186374
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.37566196
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.36708272
15Protein export_Homo sapiens_hsa030602.30106965
16Linoleic acid metabolism_Homo sapiens_hsa005912.29263262
17beta-Alanine metabolism_Homo sapiens_hsa004102.21572320
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.21507331
19Vitamin digestion and absorption_Homo sapiens_hsa049772.16785705
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.16643577
21Arginine biosynthesis_Homo sapiens_hsa002202.02100800
22Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.01657891
23Parkinsons disease_Homo sapiens_hsa050122.01106369
24Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.97030639
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.95805988
26Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.95519176
27Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.92870549
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.89038605
29Complement and coagulation cascades_Homo sapiens_hsa046101.86577105
30Cyanoamino acid metabolism_Homo sapiens_hsa004601.86372251
31RNA polymerase_Homo sapiens_hsa030201.85633498
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.81907324
33Histidine metabolism_Homo sapiens_hsa003401.81048358
34Fatty acid metabolism_Homo sapiens_hsa012121.78062831
35Retinol metabolism_Homo sapiens_hsa008301.73995001
36Nicotine addiction_Homo sapiens_hsa050331.67665822
37Fanconi anemia pathway_Homo sapiens_hsa034601.67468177
38Homologous recombination_Homo sapiens_hsa034401.66601872
39Nitrogen metabolism_Homo sapiens_hsa009101.65152261
40PPAR signaling pathway_Homo sapiens_hsa033201.62197343
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.57901748
42Huntingtons disease_Homo sapiens_hsa050161.57757093
43Ribosome_Homo sapiens_hsa030101.56499682
44Chemical carcinogenesis_Homo sapiens_hsa052041.55810244
45Bile secretion_Homo sapiens_hsa049761.53704682
46Pyruvate metabolism_Homo sapiens_hsa006201.53395842
47Phenylalanine metabolism_Homo sapiens_hsa003601.50812357
48Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.49549408
49Starch and sucrose metabolism_Homo sapiens_hsa005001.44707958
50Sulfur metabolism_Homo sapiens_hsa009201.44422395
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.42314247
52Cardiac muscle contraction_Homo sapiens_hsa042601.41934008
53Ether lipid metabolism_Homo sapiens_hsa005651.37351640
54Selenocompound metabolism_Homo sapiens_hsa004501.37169186
55Basal transcription factors_Homo sapiens_hsa030221.35704444
56Arginine and proline metabolism_Homo sapiens_hsa003301.33818411
57Alzheimers disease_Homo sapiens_hsa050101.32988499
58Lysine degradation_Homo sapiens_hsa003101.28159435
59Morphine addiction_Homo sapiens_hsa050321.27679042
60Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.27672663
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.23513843
62Proteasome_Homo sapiens_hsa030501.22878349
63Taste transduction_Homo sapiens_hsa047421.20302543
64ABC transporters_Homo sapiens_hsa020101.19687060
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.17185969
66Drug metabolism - other enzymes_Homo sapiens_hsa009831.15881459
67RNA degradation_Homo sapiens_hsa030181.15841748
68Glutathione metabolism_Homo sapiens_hsa004801.14776989
69Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.12927051
70Steroid biosynthesis_Homo sapiens_hsa001001.12317518
71Fatty acid elongation_Homo sapiens_hsa000621.05315392
72Olfactory transduction_Homo sapiens_hsa047401.04818348
73Tyrosine metabolism_Homo sapiens_hsa003501.04160382
74Staphylococcus aureus infection_Homo sapiens_hsa051501.03313274
75Collecting duct acid secretion_Homo sapiens_hsa049661.00633932
76Folate biosynthesis_Homo sapiens_hsa007900.98932999
77Basal cell carcinoma_Homo sapiens_hsa052170.95172861
78Carbon metabolism_Homo sapiens_hsa012000.92396230
79Maturity onset diabetes of the young_Homo sapiens_hsa049500.92256906
80Serotonergic synapse_Homo sapiens_hsa047260.90798399
81Protein digestion and absorption_Homo sapiens_hsa049740.88699910
82Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.88533971
83GABAergic synapse_Homo sapiens_hsa047270.83530190
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83427431
85Glutamatergic synapse_Homo sapiens_hsa047240.77782077
86Hedgehog signaling pathway_Homo sapiens_hsa043400.76088943
87TGF-beta signaling pathway_Homo sapiens_hsa043500.73031701
88Glycerolipid metabolism_Homo sapiens_hsa005610.72884882
89Circadian entrainment_Homo sapiens_hsa047130.71400792
90Caffeine metabolism_Homo sapiens_hsa002320.70764378
91Cysteine and methionine metabolism_Homo sapiens_hsa002700.70455515
92Mineral absorption_Homo sapiens_hsa049780.68055249
93Pyrimidine metabolism_Homo sapiens_hsa002400.67164616
94Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.66429634
95Purine metabolism_Homo sapiens_hsa002300.66354715
96One carbon pool by folate_Homo sapiens_hsa006700.65741542
97Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.62888669
98Insulin secretion_Homo sapiens_hsa049110.62533687
99Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.61320748
100Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.60305789
101Biosynthesis of amino acids_Homo sapiens_hsa012300.57499627
102Circadian rhythm_Homo sapiens_hsa047100.57135344
103Metabolic pathways_Homo sapiens_hsa011000.57045747
104Hippo signaling pathway_Homo sapiens_hsa043900.56382912
105p53 signaling pathway_Homo sapiens_hsa041150.56202756
106Other glycan degradation_Homo sapiens_hsa005110.54424840
107Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52206773
108Melanoma_Homo sapiens_hsa052180.47951917
109Calcium signaling pathway_Homo sapiens_hsa040200.47821344
110Vascular smooth muscle contraction_Homo sapiens_hsa042700.46700001
111Arachidonic acid metabolism_Homo sapiens_hsa005900.46371337
112Fructose and mannose metabolism_Homo sapiens_hsa000510.45397748
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44798142
114Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43940221
115Glycosaminoglycan degradation_Homo sapiens_hsa005310.42878447
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.38474338
117Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34543030
118Renin-angiotensin system_Homo sapiens_hsa046140.30494286
119Vitamin B6 metabolism_Homo sapiens_hsa007500.29741123
120Sulfur relay system_Homo sapiens_hsa041220.25757016
121Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.25529164
122Pentose phosphate pathway_Homo sapiens_hsa000300.22620354
123alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.21645272
124ECM-receptor interaction_Homo sapiens_hsa045120.20308133
125Rheumatoid arthritis_Homo sapiens_hsa053230.16293659
126Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.16273522
127Sphingolipid metabolism_Homo sapiens_hsa006000.15260698
128Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.14071177
129Fat digestion and absorption_Homo sapiens_hsa049750.13918463
130Ovarian steroidogenesis_Homo sapiens_hsa049130.13388177
131Intestinal immune network for IgA production_Homo sapiens_hsa046720.12990905
132Lysosome_Homo sapiens_hsa041420.10017025
133Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.09014473
134Thyroid hormone synthesis_Homo sapiens_hsa049180.08794096
135Hepatitis C_Homo sapiens_hsa051600.06787530
136Malaria_Homo sapiens_hsa051440.06241816
137Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.05633658
138Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.03953324
139Fatty acid biosynthesis_Homo sapiens_hsa000610.03372045
140Phagosome_Homo sapiens_hsa041450.03168822
141Galactose metabolism_Homo sapiens_hsa000520.03002494
142NF-kappa B signaling pathway_Homo sapiens_hsa040640.02373561
143Autoimmune thyroid disease_Homo sapiens_hsa053200.01556781
144Inositol phosphate metabolism_Homo sapiens_hsa00562-0.0236064
145Regulation of autophagy_Homo sapiens_hsa04140-0.0198342
146Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0095027

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