NOX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the NADPH oxidase family of enzymes responsible for the catalytic one-electron transfer of oxygen to generate superoxide or hydrogen peroxide. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of respiratory burst (GO:0060267)8.64362765
2negative regulation of telomerase activity (GO:0051974)7.47844801
3sulfate transmembrane transport (GO:1902358)6.58214238
4glomerular filtration (GO:0003094)6.24413813
5DNA damage induced protein phosphorylation (GO:0006975)6.20241975
6regulation of telomere maintenance via telomerase (GO:0032210)6.03621321
7regulation of respiratory burst (GO:0060263)5.92713764
8presynaptic membrane assembly (GO:0097105)5.91560768
9regulation of telomerase activity (GO:0051972)5.89803343
10neuron cell-cell adhesion (GO:0007158)5.64225179
11oligosaccharide biosynthetic process (GO:0009312)5.63260173
12negative regulation of telomere maintenance (GO:0032205)5.61458611
13bicarbonate transport (GO:0015701)5.61212603
14central nervous system myelination (GO:0022010)5.60439739
15axon ensheathment in central nervous system (GO:0032291)5.60439739
16sulfate transport (GO:0008272)5.53875859
17renal filtration (GO:0097205)5.53616691
18intestinal absorption (GO:0050892)5.46759409
19regulation of helicase activity (GO:0051095)5.44867027
20ventricular trabecula myocardium morphogenesis (GO:0003222)5.30129968
21presynaptic membrane organization (GO:0097090)5.24903625
22bundle of His cell to Purkinje myocyte communication (GO:0086069)5.24876144
23mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.20441854
24regulation of guanylate cyclase activity (GO:0031282)5.18883980
25positive regulation of fatty acid beta-oxidation (GO:0032000)5.06449188
26cellular glucuronidation (GO:0052695)4.94315163
27artery development (GO:0060840)4.92723101
28negative regulation of DNA biosynthetic process (GO:2000279)4.92469302
29calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.86814296
30energy coupled proton transport, down electrochemical gradient (GO:0015985)4.86615314
31ATP synthesis coupled proton transport (GO:0015986)4.86615314
32positive regulation of synaptic transmission, GABAergic (GO:0032230)4.83920573
33mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.79295760
34sperm capacitation (GO:0048240)4.77285116
35negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.69849356
36ethanol oxidation (GO:0006069)4.69717387
37uronic acid metabolic process (GO:0006063)4.66599066
38glucuronate metabolic process (GO:0019585)4.66599066
39negative regulation of leukocyte chemotaxis (GO:0002689)4.56790141
40auditory receptor cell differentiation (GO:0042491)4.53290286
41O-glycan processing (GO:0016266)4.42703570
42one-carbon metabolic process (GO:0006730)4.39586017
43long-chain fatty acid biosynthetic process (GO:0042759)4.35782217
44receptor guanylyl cyclase signaling pathway (GO:0007168)4.32915225
45maintenance of gastrointestinal epithelium (GO:0030277)4.31175368
46sulfur amino acid catabolic process (GO:0000098)4.28207402
47neuron recognition (GO:0008038)4.23993235
48bile acid and bile salt transport (GO:0015721)4.21313863
49limb bud formation (GO:0060174)4.20226172
50renal system process involved in regulation of blood volume (GO:0001977)4.17690707
51heart trabecula morphogenesis (GO:0061384)4.14691043
52positive regulation of synapse assembly (GO:0051965)4.09183606
53flavonoid metabolic process (GO:0009812)4.07580379
54dopamine biosynthetic process (GO:0042416)4.06226286
55exogenous drug catabolic process (GO:0042738)3.99791559
56lymphangiogenesis (GO:0001946)3.99759194
57telomere maintenance via telomerase (GO:0007004)3.99731503
58respiratory electron transport chain (GO:0022904)3.90005198
59nucleotide transmembrane transport (GO:1901679)3.89647926
60pyrimidine-containing compound transmembrane transport (GO:0072531)3.89010960
61ionotropic glutamate receptor signaling pathway (GO:0035235)3.88732839
62postsynaptic membrane organization (GO:0001941)3.88630583
63transmission of nerve impulse (GO:0019226)3.88481130
64glucocorticoid biosynthetic process (GO:0006704)3.83357830
65neuronal action potential propagation (GO:0019227)3.82183625
66electron transport chain (GO:0022900)3.81684642
67transcytosis (GO:0045056)3.77600595
68positive regulation of pseudopodium assembly (GO:0031274)3.76007561
69regulation of vitamin metabolic process (GO:0030656)3.73754261
70desmosome organization (GO:0002934)3.73615348
71positive regulation of DNA biosynthetic process (GO:2000573)3.73380455
72purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.64990950
733-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.64990950
74dendritic spine morphogenesis (GO:0060997)3.64973104
75positive regulation of guanylate cyclase activity (GO:0031284)3.64166598
76negative regulation of myotube differentiation (GO:0010832)3.62654023
77fucosylation (GO:0036065)3.62362907
78ethanol metabolic process (GO:0006067)3.61962724
79protein neddylation (GO:0045116)3.60744607
80glutamate receptor signaling pathway (GO:0007215)3.58799505
81drug catabolic process (GO:0042737)3.58683266
82positive regulation of fatty acid oxidation (GO:0046321)3.56620641
83protein localization to synapse (GO:0035418)3.54234715
84fatty acid elongation (GO:0030497)3.53550410
85negative regulation of synaptic transmission, GABAergic (GO:0032229)3.52299603
86retina homeostasis (GO:0001895)3.49223374
87axonal fasciculation (GO:0007413)3.47162546
88regulation of catecholamine metabolic process (GO:0042069)3.45504231
89regulation of dopamine metabolic process (GO:0042053)3.45504231
90RNA-dependent DNA replication (GO:0006278)3.44490824
91ribosomal small subunit biogenesis (GO:0042274)3.44474481
92intermediate filament organization (GO:0045109)3.44304174
93gamma-aminobutyric acid signaling pathway (GO:0007214)3.44019284
94negative regulation of neurotransmitter transport (GO:0051589)3.42361541
95vocalization behavior (GO:0071625)3.41104381
96endothelial cell differentiation (GO:0045446)3.37678189
97regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.34206056
98chaperone-mediated protein transport (GO:0072321)3.32944192
99regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.32586420
100sulfur compound transport (GO:0072348)3.32273718
101regulation of pseudopodium assembly (GO:0031272)3.28885216
102complement activation, classical pathway (GO:0006958)3.28315827
103establishment of protein localization to mitochondrial membrane (GO:0090151)3.27261466
104regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.27018193
105arginine catabolic process (GO:0006527)3.25474038
106positive regulation of prostaglandin secretion (GO:0032308)3.22932860
107trabecula morphogenesis (GO:0061383)3.20671434
108myelination (GO:0042552)3.19664367
109short-term memory (GO:0007614)3.16596389
110regulation of respiratory gaseous exchange (GO:0043576)3.16408631
111axon ensheathment (GO:0008366)3.15901402
112ensheathment of neurons (GO:0007272)3.15901402
113regulation of cGMP biosynthetic process (GO:0030826)3.14292930
114labyrinthine layer development (GO:0060711)3.13836457
115regulation of respiratory system process (GO:0044065)3.13462140
116renal system development (GO:0072001)3.13359722
117cGMP-mediated signaling (GO:0019934)3.13150148
118GTP biosynthetic process (GO:0006183)3.11447252
119startle response (GO:0001964)3.11075851
120regulation of synapse assembly (GO:0051963)3.07905803
121histone H2B ubiquitination (GO:0033523)3.04928792
122negative regulation of keratinocyte proliferation (GO:0010839)3.04343580
123negative regulation of striated muscle cell apoptotic process (GO:0010664)3.02170664
124drug metabolic process (GO:0017144)3.01653385
125neuron remodeling (GO:0016322)2.97512679
126regulation of cellular extravasation (GO:0002691)2.97431449
127epithelial structure maintenance (GO:0010669)2.96532883
128substantia nigra development (GO:0021762)2.95810870
129dendrite development (GO:0016358)2.95510561
130regulation of cardiac muscle cell apoptotic process (GO:0010665)2.95442604
131cGMP biosynthetic process (GO:0006182)2.94631220
132neuron-neuron synaptic transmission (GO:0007270)2.94401543
133sodium ion homeostasis (GO:0055078)2.93305127
134mating behavior (GO:0007617)2.92993639
135renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.91786216
136phenylpropanoid metabolic process (GO:0009698)2.91459617
137mitochondrial respiratory chain complex I assembly (GO:0032981)2.90132592
138NADH dehydrogenase complex assembly (GO:0010257)2.90132592
139mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.90132592
140synaptic transmission, glutamatergic (GO:0035249)2.89965251
141purine nucleoside bisphosphate biosynthetic process (GO:0034033)2.88976881
142ribonucleoside bisphosphate biosynthetic process (GO:0034030)2.88976881
143nucleoside bisphosphate biosynthetic process (GO:0033866)2.88976881
144positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.88044540
145positive regulation of action potential (GO:0045760)2.88016861
146oligodendrocyte differentiation (GO:0048709)2.86914258
147dopamine transport (GO:0015872)2.86407768
148cellular ketone body metabolic process (GO:0046950)2.85633682
149carnitine shuttle (GO:0006853)2.85255719
150digestive system process (GO:0022600)2.84104582
151antibacterial humoral response (GO:0019731)2.83523977
152eye photoreceptor cell differentiation (GO:0001754)2.82394065
153photoreceptor cell differentiation (GO:0046530)2.82394065
154G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.82308583
155glycerophospholipid catabolic process (GO:0046475)2.80746409
156arginine metabolic process (GO:0006525)2.80222469
157regulation of viral release from host cell (GO:1902186)2.80057216
158DNA damage response, detection of DNA damage (GO:0042769)2.76836969
159righting reflex (GO:0060013)2.75840918
160regulation of protein kinase A signaling (GO:0010738)2.75274334
161cerebral cortex radially oriented cell migration (GO:0021799)2.73673186
162keratinocyte development (GO:0003334)2.71595189
163synaptic vesicle exocytosis (GO:0016079)2.71564085
164regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.69921095
165membrane assembly (GO:0071709)2.68465927
166spinal cord motor neuron differentiation (GO:0021522)2.65990433
167cranial nerve morphogenesis (GO:0021602)2.65303676
168hydrogen ion transmembrane transport (GO:1902600)2.64607756
169regulation of glutamate secretion (GO:0014048)2.64365616
170regulation of pigment cell differentiation (GO:0050932)2.64364734
171establishment of mitochondrion localization (GO:0051654)2.63884901
172negative regulation of neurotransmitter secretion (GO:0046929)2.63283721
173regulation of glutamate receptor signaling pathway (GO:1900449)2.62705194
174adult walking behavior (GO:0007628)2.62682403
175negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.62284767
176neurotransmitter uptake (GO:0001504)2.61497416
177negative regulation of axon extension (GO:0030517)2.60956956
178synapse assembly (GO:0007416)2.59441739
179retina layer formation (GO:0010842)2.58639163
180regulation of collateral sprouting (GO:0048670)2.53508827
181positive regulation of membrane potential (GO:0045838)2.51612452
182positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.50650310
183negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.49772668
184regulation of dendritic spine development (GO:0060998)2.49164329
185catecholamine biosynthetic process (GO:0042423)2.49087871
186catechol-containing compound biosynthetic process (GO:0009713)2.49087871
187regulation of feeding behavior (GO:0060259)2.47987842
188positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.47653222
189neural nucleus development (GO:0048857)2.46740125
190synaptic transmission, dopaminergic (GO:0001963)2.45315808
191activated T cell proliferation (GO:0050798)2.44173949
192regulation of excitatory postsynaptic membrane potential (GO:0060079)2.43205321
193regulation of vesicle fusion (GO:0031338)2.42242479
194cellular response to epinephrine stimulus (GO:0071872)2.40515251
195UTP biosynthetic process (GO:0006228)2.40234865
196regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.40232330

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CDX2_20551321_ChIP-Seq_CACO-2_Human6.36510507
2EZH2_22144423_ChIP-Seq_EOC_Human4.89830593
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.74761051
4CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human3.88149467
5GBX2_23144817_ChIP-Seq_PC3_Human3.70440424
6TAF15_26573619_Chip-Seq_HEK293_Human3.46258283
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.36045797
8FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human3.25543513
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.23522846
10SOX2_27498859_Chip-Seq_STOMACH_Mouse3.09868644
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.94433226
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.72135670
13GATA4_25053715_ChIP-Seq_YYC3_Human2.71446617
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.63047337
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.62813416
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.58498377
17SOX2_20726797_ChIP-Seq_SW620_Human2.54923350
18BMI1_23680149_ChIP-Seq_NPCS_Mouse2.52443607
19CTBP1_25329375_ChIP-Seq_LNCAP_Human2.46562612
20FOXO3_23340844_ChIP-Seq_DLD1_Human2.41418088
21GATA6_25053715_ChIP-Seq_YYC3_Human2.40953892
22VDR_22108803_ChIP-Seq_LS180_Human2.35877750
23CBX2_27304074_Chip-Seq_ESCs_Mouse2.34019780
24ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.32627888
25FUS_26573619_Chip-Seq_HEK293_Human2.29578718
26SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.29523531
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.24448319
28POU3F2_20337985_ChIP-ChIP_501MEL_Human2.24227691
29EED_16625203_ChIP-ChIP_MESCs_Mouse2.23970542
30CTBP2_25329375_ChIP-Seq_LNCAP_Human2.22632489
31SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.22393763
32JARID2_20075857_ChIP-Seq_MESCs_Mouse2.21103663
33ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse2.20483841
34RNF2_18974828_ChIP-Seq_MESCs_Mouse2.13853821
35EZH2_18974828_ChIP-Seq_MESCs_Mouse2.13853821
36HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.10721912
37* HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.09465788
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.08269445
39FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.07277713
40IGF1R_20145208_ChIP-Seq_DFB_Human2.06399506
41CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.03178133
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.00498291
43P300_19829295_ChIP-Seq_ESCs_Human1.97508195
44TCF4_18268006_ChIP-ChIP_LS174T_Human1.96814565
45SUZ12_27294783_Chip-Seq_ESCs_Mouse1.91055218
46EZH2_27294783_Chip-Seq_ESCs_Mouse1.89079669
47MTF2_20144788_ChIP-Seq_MESCs_Mouse1.87545369
48AR_21572438_ChIP-Seq_LNCaP_Human1.85252252
49PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.83086512
50RNF2_27304074_Chip-Seq_NSC_Mouse1.82620604
51STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.81656052
52SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.77385130
53SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.76298615
54ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.75630109
55RNF2_27304074_Chip-Seq_ESCs_Mouse1.74402371
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.72407784
57ER_23166858_ChIP-Seq_MCF-7_Human1.72393451
58PCGF2_27294783_Chip-Seq_ESCs_Mouse1.69542744
59PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.69223182
60CDX2_22108803_ChIP-Seq_LS180_Human1.67190551
61RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.66215570
62AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.64864822
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.62925357
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.62778803
65FLI1_27457419_Chip-Seq_LIVER_Mouse1.61536795
66TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.60003923
67REST_21632747_ChIP-Seq_MESCs_Mouse1.58389221
68KLF5_25053715_ChIP-Seq_YYC3_Human1.57717044
69EWS_26573619_Chip-Seq_HEK293_Human1.54965799
70GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.54063526
71ESR1_21235772_ChIP-Seq_MCF-7_Human1.51388156
72PPARA_22158963_ChIP-Seq_LIVER_Mouse1.50292391
73EGR1_23403033_ChIP-Seq_LIVER_Mouse1.48565888
74PIAS1_25552417_ChIP-Seq_VCAP_Human1.48523693
75HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.48411000
76ESR2_21235772_ChIP-Seq_MCF-7_Human1.47836445
77POU5F1_16153702_ChIP-ChIP_HESCs_Human1.47536886
78POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.46896492
79FOXA1_25552417_ChIP-Seq_VCAP_Human1.46400177
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.45653473
81NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.45423319
82ZNF274_21170338_ChIP-Seq_K562_Hela1.45289412
83CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.44180185
84NANOG_18555785_Chip-Seq_ESCs_Mouse1.41095875
85ERG_21242973_ChIP-ChIP_JURKAT_Human1.39939592
86SMAD4_21799915_ChIP-Seq_A2780_Human1.39117731
87IRF1_19129219_ChIP-ChIP_H3396_Human1.39013740
88* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.36662196
89CDX2_19796622_ChIP-Seq_MESCs_Mouse1.36596911
90AR_21909140_ChIP-Seq_LNCAP_Human1.36106217
91RXR_22158963_ChIP-Seq_LIVER_Mouse1.34193317
92E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.32690258
93EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.32502105
94MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.32315002
95IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.31514307
96BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.31317945
97TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30691026
98SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27794219
99PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.27541883
100BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.27197498
101DROSHA_22980978_ChIP-Seq_HELA_Human1.27019355
102P53_21459846_ChIP-Seq_SAOS-2_Human1.25843302
103FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.25509549
104CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.24828165
105SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.24742391
106LXR_22158963_ChIP-Seq_LIVER_Mouse1.24485110
107CMYC_18555785_Chip-Seq_ESCs_Mouse1.23250101
108SUZ12_18555785_Chip-Seq_ESCs_Mouse1.22844082
109PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22267767
110P53_22387025_ChIP-Seq_ESCs_Mouse1.21871238
111CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.20909723
112SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20537315
113RUNX1_27514584_Chip-Seq_MCF-7_Human1.20393055
114IKZF1_21737484_ChIP-ChIP_HCT116_Human1.18670948
115EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.18176932
116E2F1_18555785_Chip-Seq_ESCs_Mouse1.17823189
117BCAT_22108803_ChIP-Seq_LS180_Human1.17311312
118P300_18555785_Chip-Seq_ESCs_Mouse1.17070408
119CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.15702537
120PRDM14_20953172_ChIP-Seq_ESCs_Human1.15146363
121EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.14984393
122SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.14418661
123RUNX2_22187159_ChIP-Seq_PCA_Human1.14377410
124WT1_19549856_ChIP-ChIP_CCG9911_Human1.13891031
125NFE2_27457419_Chip-Seq_LIVER_Mouse1.13741207
126GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12827530
127TRIM28_21343339_ChIP-Seq_HEK293_Human1.12822398
128TAL1_26923725_Chip-Seq_HPCs_Mouse1.12762443
129CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12380525
130AR_25329375_ChIP-Seq_VCAP_Human1.11485915
131TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10179574
132POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10179574
133STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.09864134
134TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09549938
135EZH2_27294783_Chip-Seq_NPCs_Mouse1.09101704
136TP53_18474530_ChIP-ChIP_U2OS_Human1.08649095
137NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.08416071
138JUN_21703547_ChIP-Seq_K562_Human1.07986496
139REST_18959480_ChIP-ChIP_MESCs_Mouse1.07880704
140TCF4_22108803_ChIP-Seq_LS180_Human1.07804133
141AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07440138
142TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07439115
143SRY_22984422_ChIP-ChIP_TESTIS_Rat1.07040959
144STAT1_20625510_ChIP-Seq_HELA_Human1.06087040
145RUNX1_27457419_Chip-Seq_LIVER_Mouse1.05642565
146SMAD_19615063_ChIP-ChIP_OVARY_Human1.04434736
147RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04108166
148STAT3_18555785_Chip-Seq_ESCs_Mouse1.03721248
149ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03278955
150SOX2_18555785_Chip-Seq_ESCs_Mouse1.02975504
151FOXM1_26456572_ChIP-Seq_MCF-7_Human1.02778530
152RING1B_27294783_Chip-Seq_ESCs_Mouse1.00810441
153RING1B_27294783_Chip-Seq_NPCs_Mouse0.99953537
154* CEBPB_22108803_ChIP-Seq_LS180_Human0.99676042
155TP53_16413492_ChIP-PET_HCT116_Human0.99457194
156NMYC_18555785_Chip-Seq_ESCs_Mouse0.99053939
157MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98896513
158PPAR_26484153_Chip-Seq_NCI-H1993_Human0.98888945
159KAP1_22055183_ChIP-Seq_ESCs_Mouse0.97516837
160ZNF217_24962896_ChIP-Seq_MCF-7_Human0.92986460
161ESR1_15608294_ChIP-ChIP_MCF-7_Human0.92755514
162NANOG_20526341_ChIP-Seq_ESCs_Human0.92716645
163PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.91418352
164HNF4A_19822575_ChIP-Seq_HepG2_Human0.84899733
165AUTS2_25519132_ChIP-Seq_293T-REX_Human0.84842774
166* SOX2_21211035_ChIP-Seq_LN229_Human0.82719142
167PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.82276473
168GATA3_24758297_ChIP-Seq_MCF-7_Human0.75621660
169AR_20517297_ChIP-Seq_VCAP_Human0.75141794
170CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.75106472
171RXR_22108803_ChIP-Seq_LS180_Human0.72011804
172RACK7_27058665_Chip-Seq_MCF-7_Human0.72007814
173* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.71673456
174ERA_21632823_ChIP-Seq_H3396_Human0.71344994
175GATA1_26923725_Chip-Seq_HPCs_Mouse0.69457530
176E2F1_20622854_ChIP-Seq_HELA_Human0.69365130

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern6.07381689
2MP0002139_abnormal_hepatobiliary_system5.60804057
3MP0010234_abnormal_vibrissa_follicle5.21013513
4MP0004043_abnormal_pH_regulation4.27168506
5MP0009379_abnormal_foot_pigmentation3.52108045
6MP0001529_abnormal_vocalization3.22799957
7MP0003136_yellow_coat_color3.09292790
8MP0006276_abnormal_autonomic_nervous3.05442976
9MP0005085_abnormal_gallbladder_physiolo3.05007404
10MP0004147_increased_porphyrin_level2.96788876
11MP0000537_abnormal_urethra_morphology2.91783899
12MP0001188_hyperpigmentation2.88659905
13MP0003866_abnormal_defecation2.77625966
14MP0001905_abnormal_dopamine_level2.75579542
15MP0004270_analgesia2.73690546
16MP0001663_abnormal_digestive_system2.68787844
17MP0003635_abnormal_synaptic_transmissio2.65404457
18MP0009745_abnormal_behavioral_response2.63125153
19MP0001486_abnormal_startle_reflex2.58628652
20MP0005409_darkened_coat_color2.52692159
21MP0005381_digestive/alimentary_phenotyp2.47325660
22MP0001968_abnormal_touch/_nociception2.45261434
23MP0002064_seizures2.39138924
24MP0005423_abnormal_somatic_nervous2.36579665
25MP0002272_abnormal_nervous_system2.36469640
26MP0000778_abnormal_nervous_system2.34918399
27MP0000477_abnormal_intestine_morphology2.31042521
28MP0003283_abnormal_digestive_organ2.28725513
29MP0004859_abnormal_synaptic_plasticity2.27671437
30MP0010352_gastrointestinal_tract_polyps2.25478231
31MP0000490_abnormal_crypts_of2.23386788
32MP0002572_abnormal_emotion/affect_behav2.23142572
33MP0008875_abnormal_xenobiotic_pharmacok2.22132530
34MP0005365_abnormal_bile_salt2.18767835
35MP0001765_abnormal_ion_homeostasis2.15889453
36MP0006292_abnormal_olfactory_placode2.11922667
37MP0004142_abnormal_muscle_tone2.10725032
38MP0009046_muscle_twitch2.09098730
39MP0002734_abnormal_mechanical_nocicepti2.04983860
40MP0001440_abnormal_grooming_behavior2.03438604
41MP0001501_abnormal_sleep_pattern2.00502081
42MP0003868_abnormal_feces_composition1.98971576
43MP0004742_abnormal_vestibular_system1.97562495
44MP0002063_abnormal_learning/memory/cond1.97529515
45MP0010155_abnormal_intestine_physiology1.94182161
46MP0003693_abnormal_embryo_hatching1.92593990
47MP0001873_stomach_inflammation1.91470169
48MP0002736_abnormal_nociception_after1.89422899
49MP0000920_abnormal_myelination1.87318069
50MP0005636_abnormal_mineral_homeostasis1.87018224
51MP0002067_abnormal_sensory_capabilities1.83667089
52MP0002098_abnormal_vibrissa_morphology1.82067810
53MP0004264_abnormal_extraembryonic_tissu1.79199246
54MP0001666_abnormal_nutrient_absorption1.75958670
55MP0002735_abnormal_chemical_nociception1.71932678
56MP0004381_abnormal_hair_follicle1.68737971
57MP0002138_abnormal_hepatobiliary_system1.66956529
58MP0002102_abnormal_ear_morphology1.58566697
59MP0010678_abnormal_skin_adnexa1.58018158
60MP0001970_abnormal_pain_threshold1.57779315
61MP0002733_abnormal_thermal_nociception1.57442268
62MP0002557_abnormal_social/conspecific_i1.55936079
63MP0005386_behavior/neurological_phenoty1.53517131
64MP0004924_abnormal_behavior1.53517131
65MP0005187_abnormal_penis_morphology1.53236007
66MP0002184_abnormal_innervation1.52110253
67MP0002796_impaired_skin_barrier1.51349591
68MP0003806_abnormal_nucleotide_metabolis1.44409619
69MP0005645_abnormal_hypothalamus_physiol1.42909551
70MP0004133_heterotaxia1.34558177
71MP0005551_abnormal_eye_electrophysiolog1.31984011
72MP0003122_maternal_imprinting1.31829713
73MP0003938_abnormal_ear_development1.31499110
74MP0005646_abnormal_pituitary_gland1.31270187
75MP0001485_abnormal_pinna_reflex1.28279895
76MP0002882_abnormal_neuron_morphology1.26890566
77MP0004782_abnormal_surfactant_physiolog1.26841346
78MP0002638_abnormal_pupillary_reflex1.25947340
79MP0000465_gastrointestinal_hemorrhage1.25871135
80MP0005379_endocrine/exocrine_gland_phen1.22644931
81MP0009250_abnormal_appendicular_skeleto1.22356016
82MP0005670_abnormal_white_adipose1.21141240
83MP0010030_abnormal_orbit_morphology1.20679229
84MP0002066_abnormal_motor_capabilities/c1.19757521
85MP0000678_abnormal_parathyroid_gland1.19211298
86MP0001764_abnormal_homeostasis1.18788040
87MP0008775_abnormal_heart_ventricle1.16963880
88MP0000026_abnormal_inner_ear1.16554727
89MP0001963_abnormal_hearing_physiology1.16471101
90MP0000955_abnormal_spinal_cord1.15496957
91MP0002249_abnormal_larynx_morphology1.14350816
92MP0000647_abnormal_sebaceous_gland1.13255795
93MP0008872_abnormal_physiological_respon1.12998110
94MP0002752_abnormal_somatic_nervous1.12941773
95MP0000470_abnormal_stomach_morphology1.12588790
96MP0000383_abnormal_hair_follicle1.12108042
97MP0000631_abnormal_neuroendocrine_gland1.09615918
98MP0000462_abnormal_digestive_system1.09246779
99MP0005166_decreased_susceptibility_to1.07504455
100MP0002127_abnormal_cardiovascular_syste1.06208494
101MP0005501_abnormal_skin_physiology1.05114667
102MP0006072_abnormal_retinal_apoptosis1.04973901
103MP0003315_abnormal_perineum_morphology1.04113917
104MP0001984_abnormal_olfaction1.01437884
105MP0001756_abnormal_urination1.01024888
106MP0005332_abnormal_amino_acid1.00875403
107MP0005171_absent_coat_pigmentation1.00110565
108MP0002751_abnormal_autonomic_nervous0.99238188
109MP0001664_abnormal_digestion0.98939207
110MP0002229_neurodegeneration0.98580176
111MP0003329_amyloid_beta_deposits0.98059373
112MP0000467_abnormal_esophagus_morphology0.94452498
113MP0003879_abnormal_hair_cell0.92971519
114MP0002152_abnormal_brain_morphology0.92404085
115MP0004885_abnormal_endolymph0.91783112
116* MP0000230_abnormal_systemic_arterial0.90722696
117MP0008569_lethality_at_weaning0.89290459
118MP0003634_abnormal_glial_cell0.89287069
119MP0002163_abnormal_gland_morphology0.88609061
120MP0001986_abnormal_taste_sensitivity0.87691251
121MP0000566_synostosis0.87241574
122MP0002277_abnormal_respiratory_mucosa0.83544940
123MP0002932_abnormal_joint_morphology0.83129707
124MP0004145_abnormal_muscle_electrophysio0.81724529
125MP0000049_abnormal_middle_ear0.80991526
126MP0001727_abnormal_embryo_implantation0.78320023
127MP0000015_abnormal_ear_pigmentation0.77326755
128MP0002822_catalepsy0.76469734
129MP0003252_abnormal_bile_duct0.75054250
130MP0003787_abnormal_imprinting0.74812372
131MP0005174_abnormal_tail_pigmentation0.74548114
132MP0002177_abnormal_outer_ear0.74472067
133MP0001502_abnormal_circadian_rhythm0.73801136
134MP0002111_abnormal_tail_morphology0.73729307
135MP0005253_abnormal_eye_physiology0.73324867
136MP0000538_abnormal_urinary_bladder0.73119733
137MP0009643_abnormal_urine_homeostasis0.72920094
138MP0002876_abnormal_thyroid_physiology0.72705715
139MP0008260_abnormal_autophagy0.72480112
140MP0003937_abnormal_limbs/digits/tail_de0.72045066
141MP0005195_abnormal_posterior_eye0.71542241
142* MP0005595_abnormal_vascular_smooth0.71254328
143MP0001943_abnormal_respiration0.70445033
144MP0003861_abnormal_nervous_system0.70419743
145MP0002089_abnormal_postnatal_growth/wei0.69568218
146MP0002136_abnormal_kidney_physiology0.68091241
147MP0005310_abnormal_salivary_gland0.67889940
148MP0000427_abnormal_hair_cycle0.67187564
149MP0000377_abnormal_hair_follicle0.66846554
150MP0004811_abnormal_neuron_physiology0.66371334
151MP0002233_abnormal_nose_morphology0.66305808
152MP0005410_abnormal_fertilization0.65762256
153MP0000613_abnormal_salivary_gland0.65364158
154MP0002069_abnormal_eating/drinking_beha0.63592361
155MP0005451_abnormal_body_composition0.63252395
156MP0003121_genomic_imprinting0.62908342
157MP0005394_taste/olfaction_phenotype0.62770281
158MP0005499_abnormal_olfactory_system0.62770281
159MP0001346_abnormal_lacrimal_gland0.61753473
160MP0000762_abnormal_tongue_morphology0.61537856
161MP0003567_abnormal_fetal_cardiomyocyte0.60894698
162MP0001177_atelectasis0.60598506
163MP0003632_abnormal_nervous_system0.60328954
164MP0010386_abnormal_urinary_bladder0.60121646
165MP0001216_abnormal_epidermal_layer0.60084613
166MP0003724_increased_susceptibility_to0.59886674
167MP0003941_abnormal_skin_development0.59779006
168MP0003385_abnormal_body_wall0.59417181
169MP0002896_abnormal_bone_mineralization0.57178323
170* MP0005319_abnormal_enzyme/_coenzyme0.54526898
171MP0009053_abnormal_anal_canal0.53537818
172MP0005360_urolithiasis0.52866984
173MP0008004_abnormal_stomach_pH0.52647082
174MP0001919_abnormal_reproductive_system0.49874259
175MP0003953_abnormal_hormone_level0.49163699
176MP0004484_altered_response_of0.48853575

Predicted human phenotypes

RankGene SetZ-score
1Decreased circulating renin level (HP:0003351)8.01755727
2Abnormality of renin-angiotensin system (HP:0000847)7.27687167
3Metabolic alkalosis (HP:0200114)7.17279686
4Abnormality of chloride homeostasis (HP:0011422)5.84408222
5Hyperaldosteronism (HP:0000859)5.33795237
6Alkalosis (HP:0001948)5.17323746
7Esophageal atresia (HP:0002032)4.71539720
8Hyponatremia (HP:0002902)4.33023035
9Acute necrotizing encephalopathy (HP:0006965)4.22533900
10Focal motor seizures (HP:0011153)4.20474255
11Parakeratosis (HP:0001036)4.04833942
12Intrahepatic cholestasis (HP:0001406)4.03702601
13Hypokalemia (HP:0002900)3.98881680
14Right ventricular cardiomyopathy (HP:0011663)3.98412101
15Conjugated hyperbilirubinemia (HP:0002908)3.98172222
16Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.93454208
17Ileus (HP:0002595)3.84947868
18Progressive macrocephaly (HP:0004481)3.83618735
19Flat acetabular roof (HP:0003180)3.74202949
20Abnormality of potassium homeostasis (HP:0011042)3.64040790
21Congenital sensorineural hearing impairment (HP:0008527)3.58553274
22Abnormality of the distal phalanx of the thumb (HP:0009617)3.57846772
23Mitochondrial inheritance (HP:0001427)3.54738606
24Abnormality of monocarboxylic acid metabolism (HP:0010996)3.53131156
25Atonic seizures (HP:0010819)3.48355927
26Abnormality of the aortic arch (HP:0012303)3.48287950
27Hyperkalemia (HP:0002153)3.48019741
28Abnormal mitochondria in muscle tissue (HP:0008316)3.39675505
29Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.31711688
30Degeneration of the lateral corticospinal tracts (HP:0002314)3.31711688
31Increased hepatocellular lipid droplets (HP:0006565)3.24294838
32Pili torti (HP:0003777)3.23414370
33Abnormality of sodium homeostasis (HP:0010931)3.16686620
34Acute encephalopathy (HP:0006846)3.16094686
35Broad-based gait (HP:0002136)3.15732589
36Optic disc pallor (HP:0000543)3.14726805
37Renal Fanconi syndrome (HP:0001994)3.12173434
38Abdominal distention (HP:0003270)3.09567838
39Flattened epiphyses (HP:0003071)3.08438071
40Neonatal short-limb short stature (HP:0008921)3.04146030
41Progressive inability to walk (HP:0002505)3.03937915
42Hepatocellular necrosis (HP:0001404)2.96457563
43Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.95760140
44Symphalangism affecting the phalanges of the hand (HP:0009773)2.93320706
45Flat capital femoral epiphysis (HP:0003370)2.90578098
46Dynein arm defect of respiratory motile cilia (HP:0012255)2.89572945
47Absent/shortened dynein arms (HP:0200106)2.89572945
48Abnormal tarsal ossification (HP:0008369)2.88226243
49Hyperventilation (HP:0002883)2.84559574
50Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.82347674
51Aplasia cutis congenita (HP:0001057)2.81091225
52Abnormality of the vitamin B12 metabolism (HP:0004341)2.79544062
53Curly hair (HP:0002212)2.79252846
54Limb dystonia (HP:0002451)2.75578420
55Abnormality of glutamine family amino acid metabolism (HP:0010902)2.75225910
56Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.73674627
57Large earlobe (HP:0009748)2.73235658
58Focal seizures (HP:0007359)2.73090325
59Sensory axonal neuropathy (HP:0003390)2.70726072
60Hypothermia (HP:0002045)2.70595289
61Increased CSF lactate (HP:0002490)2.69302401
62Dialeptic seizures (HP:0011146)2.65342567
63Excessive salivation (HP:0003781)2.64081301
64Drooling (HP:0002307)2.64081301
65Gastrointestinal atresia (HP:0002589)2.62436968
66Absence seizures (HP:0002121)2.61868485
67Neurofibrillary tangles (HP:0002185)2.59819065
68Adrenal overactivity (HP:0002717)2.55647205
69Concave nail (HP:0001598)2.53817310
70Abnormality of vitamin B metabolism (HP:0004340)2.51991152
71Lipid accumulation in hepatocytes (HP:0006561)2.50941823
72Chronic bronchitis (HP:0004469)2.48608953
73Leukodystrophy (HP:0002415)2.47801319
74Ureteral stenosis (HP:0000071)2.47352294
75Abnormality of the 1st metacarpal (HP:0010009)2.46613017
76Epileptic encephalopathy (HP:0200134)2.45591862
77Abnormal ciliary motility (HP:0012262)2.45479736
78Abnormality of the corticospinal tract (HP:0002492)2.44647316
79Abnormality of the axillary hair (HP:0100134)2.42754255
80Abnormality of secondary sexual hair (HP:0009888)2.42754255
81Congenital ichthyosiform erythroderma (HP:0007431)2.42475321
82Hypokinesia (HP:0002375)2.41708077
83Esotropia (HP:0000565)2.41543281
84Syncope (HP:0001279)2.41303100
85Retinal dysplasia (HP:0007973)2.41234894
86Medial flaring of the eyebrow (HP:0010747)2.41161871
87Hypophosphatemic rickets (HP:0004912)2.35866375
88Villous atrophy (HP:0011473)2.33295916
89Abnormality of small intestinal villus morphology (HP:0011472)2.33295916
90Abnormal hair whorl (HP:0010721)2.32932675
91Gait imbalance (HP:0002141)2.32788490
923-Methylglutaconic aciduria (HP:0003535)2.32065739
93Spinal cord compression (HP:0002176)2.29132308
94Fat malabsorption (HP:0002630)2.28786369
95Visceral angiomatosis (HP:0100761)2.25860262
96Short middle phalanx of finger (HP:0005819)2.25391409
97Aplasia/Hypoplasia of the tibia (HP:0005772)2.25073399
98Congenital, generalized hypertrichosis (HP:0004540)2.23736301
99Febrile seizures (HP:0002373)2.22578447
100Inability to walk (HP:0002540)2.21501664
101Abnormal biliary tract morphology (HP:0012440)2.21175132
102Hemorrhage of the eye (HP:0011885)2.21062144
103Myokymia (HP:0002411)2.20557415
104Protruding tongue (HP:0010808)2.20125423
105Metabolic acidosis (HP:0001942)2.18936569
106Abnormal respiratory epithelium morphology (HP:0012253)2.18581970
107Abnormal respiratory motile cilium morphology (HP:0005938)2.18581970
108Abnormal pupillary function (HP:0007686)2.18337383
109Abnormal respiratory motile cilium physiology (HP:0012261)2.17373876
110Dehydration (HP:0001944)2.15853331
111Abnormality of the septum pellucidum (HP:0007375)2.14845922
112Abnormal hair laboratory examination (HP:0003328)2.14328430
113Increased serum pyruvate (HP:0003542)2.14303838
114Abnormality of glycolysis (HP:0004366)2.14303838
115Ureteral obstruction (HP:0006000)2.13928999
116Cerebral hypomyelination (HP:0006808)2.13474339
117Hemangiomatosis (HP:0007461)2.13225967
118Polyphagia (HP:0002591)2.13018826
119Abnormality of salivation (HP:0100755)2.11284974
120Genital tract atresia (HP:0001827)2.10651465
121Abnormality of the phalanges of the hallux (HP:0010057)2.10184186
122Abnormality of dicarboxylic acid metabolism (HP:0010995)2.10063842
123Dicarboxylic aciduria (HP:0003215)2.10063842
124Vertebral hypoplasia (HP:0008417)2.09230051
125Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.09230051
126X-linked dominant inheritance (HP:0001423)2.09192854
127Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.08973883
128Short phalanx of the thumb (HP:0009660)2.08461758
129Vaginal atresia (HP:0000148)2.07054894
130Absent septum pellucidum (HP:0001331)2.07016865
131Generalized tonic-clonic seizures (HP:0002069)2.06832264
132Absent speech (HP:0001344)2.06073541
133Progressive cerebellar ataxia (HP:0002073)2.04384919
134Peripheral hypomyelination (HP:0007182)2.04137527
135Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.03869630
136Abnormal vertebral ossification (HP:0100569)2.02501237
137Congenital primary aphakia (HP:0007707)2.00955158
138Abnormality of renal resorption (HP:0011038)2.00597865
139Atelectasis (HP:0100750)2.00080783
140Hyperactive renin-angiotensin system (HP:0000841)10.4903048
141Fragile skin (HP:0001030)1.99081619
142Flat occiput (HP:0005469)1.98526503
143Aplasia/Hypoplasia of the sacrum (HP:0008517)1.97312429
144Mutism (HP:0002300)1.96011384
145Visual hallucinations (HP:0002367)1.95363787
146Abnormality of vitamin metabolism (HP:0100508)1.95304000
147Partial duplication of thumb phalanx (HP:0009944)1.94129576
148Fair hair (HP:0002286)1.93952287
149Renal salt wasting (HP:0000127)1.93722019
150Abnormality of carpal bone ossification (HP:0006257)1.90755530
151Abnormal foot bone ossification (HP:0010675)1.90715951
152Irregular epiphyses (HP:0010582)1.89508774
153Hepatic necrosis (HP:0002605)1.88650015
154Macrocytic anemia (HP:0001972)1.88389007
155Milia (HP:0001056)1.85996243
156Cupped ear (HP:0000378)1.85433772
157Cerebral inclusion bodies (HP:0100314)1.85352440
158Exertional dyspnea (HP:0002875)1.85125473
159Vertebral clefting (HP:0008428)1.82424506
160Respiratory failure (HP:0002878)1.82157567
161Abnormal hand bone ossification (HP:0010660)1.81886539
162Spastic gait (HP:0002064)1.79705999
163Palpitations (HP:0001962)1.79439060
164Hip contracture (HP:0003273)1.79067321
165Upper limb muscle weakness (HP:0003484)1.78407168
166Exercise intolerance (HP:0003546)1.77863523
167Increased intramyocellular lipid droplets (HP:0012240)1.77726597
168Amblyopia (HP:0000646)1.75271470
169Nephrogenic diabetes insipidus (HP:0009806)1.74352680
170Dysmetria (HP:0001310)1.73594244
171Hypoplastic pelvis (HP:0008839)1.73478711
172Pterygium (HP:0001059)1.72087330
173Clumsiness (HP:0002312)1.71717285
174Breech presentation (HP:0001623)1.71640884
175Generalized myoclonic seizures (HP:0002123)1.71223996
176Rectal prolapse (HP:0002035)1.70969948
177Cerebral edema (HP:0002181)1.70905638
178Short tibia (HP:0005736)1.70619618
179Nasolacrimal duct obstruction (HP:0000579)1.69692326
180Ventricular fibrillation (HP:0001663)1.69367263
181Neoplasm of the pancreas (HP:0002894)1.69171215
182Exotropia (HP:0000577)1.69125070
183Septo-optic dysplasia (HP:0100842)1.69122309
184Broad metatarsal (HP:0001783)1.67938934
185Abnormality of the middle phalanges of the toes (HP:0010183)1.67758302
186Woolly hair (HP:0002224)1.67416477
187Hyperparathyroidism (HP:0000843)1.65913736
188Partial duplication of the phalanx of hand (HP:0009999)1.64087443
189Renal tubular acidosis (HP:0001947)1.63894669
190Hyperammonemia (HP:0001987)1.63653308
191Aplasia/hypoplasia of the femur (HP:0005613)1.63396431
192Ragged-red muscle fibers (HP:0003200)1.59167336

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK28.64777777
2MAP2K64.84587676
3CASK4.69756843
4PIK3CA4.35324660
5MST1R4.19371826
6EPHA24.19082541
7LMTK23.41570745
8STK393.34463479
9RIPK13.12769925
10PNCK3.06848639
11ACVR1B2.84254426
12TNIK2.84117331
13OXSR12.54552684
14STK162.43505778
15MAP3K52.37245677
16INSRR2.30777486
17MARK12.28750633
18NME12.20241419
19BMPR1B2.16504460
20MAP4K22.05674311
21CDK192.02933418
22MET1.95035243
23NTRK31.86723732
24MUSK1.83941285
25BRSK21.79515877
26TLK11.75776651
27FES1.72191223
28MAPKAPK51.69691317
29MAP3K121.67562313
30MAPK131.64854822
31PKN11.63173825
32UHMK11.62704378
33IRAK21.58283793
34MAP2K71.53698304
35PBK1.53317290
36MST41.49147029
37CAMK2B1.41398785
38FGR1.38690145
39WNK41.38682588
40BCR1.38613062
41CSNK1G31.38535477
42MKNK21.36991202
43IRAK41.33705347
44GRK71.29645062
45EPHA41.27312615
46MAP3K41.21460110
47MKNK11.20365796
48VRK21.20174299
49STK241.20133482
50IRAK11.19351350
51WEE11.13234444
52TAF11.10366381
53ARAF1.08694331
54CAMK2A1.08068388
55MAP3K81.07179745
56DYRK21.06194061
57CSNK1G21.05947828
58CSNK1G11.00825492
59NUAK10.99402819
60SIK20.98711480
61ADRBK20.98684761
62NTRK20.97503845
63CSNK1A1L0.96416272
64EPHB10.96270234
65CAMK2D0.94060480
66VRK10.93137474
67BMPR20.92610399
68PLK20.91015189
69RIPK40.88711732
70PRKG20.85294696
71CLK10.84366219
72BLK0.83050229
73MAP3K100.77622450
74MINK10.75753869
75CDK50.73820581
76PTK60.72561730
77IRAK30.70511201
78GRK50.69027390
79WNK30.67936092
80DMPK0.66433482
81NEK60.66001954
82NTRK10.65643757
83ROCK20.65281887
84CDK140.64982070
85LIMK10.64744444
86MAPK150.63922844
87PRKCE0.62731078
88MAPKAPK30.62448331
89STK110.62404412
90CAMK2G0.61965522
91PDK20.60074643
92MARK20.57639197
93SMG10.57469498
94CDK30.55306471
95DYRK1A0.55209631
96ADRBK10.53373711
97BRSK10.51659899
98PRPF4B0.51443387
99CDK150.51363762
100CDK180.50735983
101MELK0.50558766
102CDK11A0.49194246
103YES10.49004187
104SIK10.48763539
105RPS6KA50.48085182
106MAP2K40.47062694
107NME20.46991148
108PRKD20.46380463
109TYRO30.46282582
110KSR10.44858568
111BUB10.44570696
112WNK10.44511879
113TTK0.41971831
114ERBB40.41750817
115PRKCG0.41260351
116PRKACA0.41106789
117SRPK10.40422219
118EPHB20.37506067
119PAK30.37465731
120PRKCQ0.37243215
121DDR20.36978813
122CSNK1E0.36662826
123DYRK30.36654220
124MAPK40.36404689
125CAMK10.35319898
126PRKG10.34998476
127EIF2AK20.34382500
128MAP3K60.33258461
129FYN0.29978872
130HIPK20.29281276
131CSNK1A10.28504489
132ABL20.28048100
133PRKAA20.28016461
134FGFR20.27427733
135RPS6KB20.26473368
136ERBB20.25199444
137PRKCI0.23501012
138EPHA30.23089771
139MAP2K20.22342351
140MATK0.21668339
141GRK10.21071531
142PRKCA0.17657481
143PDPK10.15782721
144MAP3K20.15604502
145PRKACG0.15141963
146MYLK0.14254129
147TESK20.14058472
148FER0.13626089
149MAPK110.10984819
150PLK10.10825560
151PAK40.10213046
152FRK0.07355887
153STK38L0.07133284
154CSNK2A10.06747269
155NEK90.06698123
156STK40.06204705
157BMX0.05956458
158PRKAA10.05900687
159CSNK2A20.04248470
160ERN10.03017104
161PLK40.01282215
162AURKB0.00765947

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009105.29463916
2Oxidative phosphorylation_Homo sapiens_hsa001904.49064230
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.88696476
4Nicotine addiction_Homo sapiens_hsa050333.63477986
5Parkinsons disease_Homo sapiens_hsa050123.45713335
6Caffeine metabolism_Homo sapiens_hsa002323.45318430
7Alzheimers disease_Homo sapiens_hsa050103.03798974
8Cyanoamino acid metabolism_Homo sapiens_hsa004603.02378177
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.60197138
10Ribosome_Homo sapiens_hsa030102.56890782
11Huntingtons disease_Homo sapiens_hsa050162.43872576
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.42451672
13Mineral absorption_Homo sapiens_hsa049782.36874032
14Protein export_Homo sapiens_hsa030602.35014666
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.22810954
16Serotonergic synapse_Homo sapiens_hsa047262.19905231
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.18511780
18Retinol metabolism_Homo sapiens_hsa008302.16698959
19Cardiac muscle contraction_Homo sapiens_hsa042602.05745742
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.00744895
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.99267077
22Glutamatergic synapse_Homo sapiens_hsa047241.94361407
23Collecting duct acid secretion_Homo sapiens_hsa049661.93975536
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.92430234
25Fatty acid degradation_Homo sapiens_hsa000711.89544042
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.86272975
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.82699450
28GABAergic synapse_Homo sapiens_hsa047271.81408171
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.80209141
30Morphine addiction_Homo sapiens_hsa050321.76550749
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.75694040
32Fat digestion and absorption_Homo sapiens_hsa049751.75633790
33Ether lipid metabolism_Homo sapiens_hsa005651.72441499
34Long-term depression_Homo sapiens_hsa047301.72188784
35Chemical carcinogenesis_Homo sapiens_hsa052041.70664462
36Taste transduction_Homo sapiens_hsa047421.68958640
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.68850139
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.66573590
39Steroid biosynthesis_Homo sapiens_hsa001001.66273445
40Amphetamine addiction_Homo sapiens_hsa050311.57972782
41Arginine biosynthesis_Homo sapiens_hsa002201.57951524
42RNA polymerase_Homo sapiens_hsa030201.55221573
43Phototransduction_Homo sapiens_hsa047441.55001930
44Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.54569654
45Sulfur relay system_Homo sapiens_hsa041221.54496999
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.47715236
47Fatty acid elongation_Homo sapiens_hsa000621.47341997
48Cocaine addiction_Homo sapiens_hsa050301.45566799
49Axon guidance_Homo sapiens_hsa043601.45459037
50Vibrio cholerae infection_Homo sapiens_hsa051101.44717554
51Maturity onset diabetes of the young_Homo sapiens_hsa049501.43808835
52Synaptic vesicle cycle_Homo sapiens_hsa047211.42415673
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.39697521
54Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.39485427
55Dopaminergic synapse_Homo sapiens_hsa047281.37151850
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.31633179
57Circadian entrainment_Homo sapiens_hsa047131.31158798
58Long-term potentiation_Homo sapiens_hsa047201.30098551
59Sphingolipid metabolism_Homo sapiens_hsa006001.26506185
60Bile secretion_Homo sapiens_hsa049761.26045356
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.17539790
62PPAR signaling pathway_Homo sapiens_hsa033201.17391305
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.16021124
64Tryptophan metabolism_Homo sapiens_hsa003801.13678083
65Salivary secretion_Homo sapiens_hsa049701.12296202
66Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.10937260
67Starch and sucrose metabolism_Homo sapiens_hsa005001.10251119
68Cholinergic synapse_Homo sapiens_hsa047251.09598845
69Sulfur metabolism_Homo sapiens_hsa009201.04839395
70Arginine and proline metabolism_Homo sapiens_hsa003301.02361153
71Propanoate metabolism_Homo sapiens_hsa006400.98565024
72Renin secretion_Homo sapiens_hsa049240.94609132
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.92165722
74Calcium signaling pathway_Homo sapiens_hsa040200.91801198
75Glutathione metabolism_Homo sapiens_hsa004800.90340497
76Fructose and mannose metabolism_Homo sapiens_hsa000510.90076391
77Olfactory transduction_Homo sapiens_hsa047400.89383124
78Proteasome_Homo sapiens_hsa030500.87360171
79Primary bile acid biosynthesis_Homo sapiens_hsa001200.86774188
802-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.86767275
81Rheumatoid arthritis_Homo sapiens_hsa053230.86159629
82Oxytocin signaling pathway_Homo sapiens_hsa049210.82474307
83Linoleic acid metabolism_Homo sapiens_hsa005910.82389644
84Glycerolipid metabolism_Homo sapiens_hsa005610.81332977
85Fatty acid metabolism_Homo sapiens_hsa012120.80892655
86Pyruvate metabolism_Homo sapiens_hsa006200.76306873
87Gastric acid secretion_Homo sapiens_hsa049710.72033571
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.69704090
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69297846
90Basal transcription factors_Homo sapiens_hsa030220.69048557
91Arachidonic acid metabolism_Homo sapiens_hsa005900.68774767
92Melanogenesis_Homo sapiens_hsa049160.67056239
93Peroxisome_Homo sapiens_hsa041460.63716573
94Gap junction_Homo sapiens_hsa045400.63391879
95Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59166690
96Tight junction_Homo sapiens_hsa045300.58594017
97Insulin secretion_Homo sapiens_hsa049110.56576109
98Ras signaling pathway_Homo sapiens_hsa040140.56271130
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54996616
100Alcoholism_Homo sapiens_hsa050340.54899978
101Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54213812
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.53972047
103Wnt signaling pathway_Homo sapiens_hsa043100.53284156
104GnRH signaling pathway_Homo sapiens_hsa049120.52733314
105Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.51490858
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51139110
107Aldosterone synthesis and secretion_Homo sapiens_hsa049250.51003411
108Cysteine and methionine metabolism_Homo sapiens_hsa002700.50237962
109cAMP signaling pathway_Homo sapiens_hsa040240.48346120
110Pancreatic secretion_Homo sapiens_hsa049720.47693487
111African trypanosomiasis_Homo sapiens_hsa051430.47376852
112Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47246883
113Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46980538
114alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46009243
115ErbB signaling pathway_Homo sapiens_hsa040120.45657670
116Intestinal immune network for IgA production_Homo sapiens_hsa046720.44182176
117Renin-angiotensin system_Homo sapiens_hsa046140.43397776
118Phospholipase D signaling pathway_Homo sapiens_hsa040720.41908173
119Choline metabolism in cancer_Homo sapiens_hsa052310.40728169
120Metabolic pathways_Homo sapiens_hsa011000.40227237
121* Phagosome_Homo sapiens_hsa041450.39598861
122Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.39133646
123Histidine metabolism_Homo sapiens_hsa003400.38181243
124Ovarian steroidogenesis_Homo sapiens_hsa049130.37708764
125Phenylalanine metabolism_Homo sapiens_hsa003600.36963118
126Autoimmune thyroid disease_Homo sapiens_hsa053200.34917813
127Purine metabolism_Homo sapiens_hsa002300.34205083
128beta-Alanine metabolism_Homo sapiens_hsa004100.33674529
129MAPK signaling pathway_Homo sapiens_hsa040100.33589585
130Pyrimidine metabolism_Homo sapiens_hsa002400.33091588
131Tyrosine metabolism_Homo sapiens_hsa003500.32773813
132Thyroid hormone synthesis_Homo sapiens_hsa049180.32695481
133Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32196402
134Spliceosome_Homo sapiens_hsa030400.32137145
135Homologous recombination_Homo sapiens_hsa034400.32035763
136Renal cell carcinoma_Homo sapiens_hsa052110.32012382
137Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.30520828
138Hedgehog signaling pathway_Homo sapiens_hsa043400.30161189
139Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.30112101
140Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.28887858
141Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.26666127
142Phosphatidylinositol signaling system_Homo sapiens_hsa040700.26098884
143Protein digestion and absorption_Homo sapiens_hsa049740.25240239
144Butanoate metabolism_Homo sapiens_hsa006500.25185760
145Estrogen signaling pathway_Homo sapiens_hsa049150.25153641
146Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.24874026
147Non-homologous end-joining_Homo sapiens_hsa034500.24594196
148Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.24559812
149Galactose metabolism_Homo sapiens_hsa000520.24397784
150Carbon metabolism_Homo sapiens_hsa012000.23632962
151cGMP-PKG signaling pathway_Homo sapiens_hsa040220.23204690
152Oocyte meiosis_Homo sapiens_hsa041140.23148690
153Fatty acid biosynthesis_Homo sapiens_hsa000610.23082462
154Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.23002924
155Regulation of autophagy_Homo sapiens_hsa041400.22572311
156Asthma_Homo sapiens_hsa053100.21886796
157TGF-beta signaling pathway_Homo sapiens_hsa043500.21729006
158Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.15793183
159Complement and coagulation cascades_Homo sapiens_hsa046100.14231763
160Selenocompound metabolism_Homo sapiens_hsa004500.03796908
161Hepatitis C_Homo sapiens_hsa051600.02487876
162Vitamin digestion and absorption_Homo sapiens_hsa049770.00514077
163Folate biosynthesis_Homo sapiens_hsa00790-0.0014948

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