NOTCH3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1atrioventricular valve morphogenesis (GO:0003181)4.66060992
2epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)4.60366165
3paraxial mesoderm development (GO:0048339)4.56829713
4cell migration involved in heart development (GO:0060973)4.42533084
5endocardial cushion morphogenesis (GO:0003203)4.34478279
6cardiac myofibril assembly (GO:0055003)4.25409929
7planar cell polarity pathway involved in neural tube closure (GO:0090179)4.19649015
8protein heterotrimerization (GO:0070208)4.17530890
9regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.99133544
10polarized epithelial cell differentiation (GO:0030859)3.91991901
11convergent extension (GO:0060026)3.82775674
12vascular endothelial growth factor signaling pathway (GO:0038084)3.75195365
13plasma membrane repair (GO:0001778)3.63292864
14mesenchyme morphogenesis (GO:0072132)3.53592835
15cell proliferation involved in metanephros development (GO:0072203)3.52814109
16hippo signaling (GO:0035329)3.52417371
17glomerular filtration (GO:0003094)3.48755486
18renal filtration (GO:0097205)3.48066788
19semaphorin-plexin signaling pathway (GO:0071526)3.45448462
20aorta morphogenesis (GO:0035909)3.41140586
21regulation of hippo signaling (GO:0035330)3.38678017
22retina vasculature morphogenesis in camera-type eye (GO:0061299)3.38284303
23basement membrane organization (GO:0071711)3.38213045
24coronary vasculature morphogenesis (GO:0060977)3.32448425
25myofibril assembly (GO:0030239)3.31322875
26establishment of apical/basal cell polarity (GO:0035089)3.29628899
27regulation of posttranscriptional gene silencing (GO:0060147)3.27012458
28regulation of gene silencing by miRNA (GO:0060964)3.27012458
29regulation of gene silencing by RNA (GO:0060966)3.27012458
30regulation of water loss via skin (GO:0033561)3.24433973
31endothelial cell chemotaxis (GO:0035767)3.24026956
32lateral sprouting from an epithelium (GO:0060601)3.19283013
33cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.17718512
34cell surface receptor signaling pathway involved in heart development (GO:0061311)3.14831700
35adherens junction assembly (GO:0034333)3.14721225
36epithelial cell-cell adhesion (GO:0090136)3.14527938
37regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.13576404
38establishment of skin barrier (GO:0061436)3.11817264
39metanephric mesenchyme development (GO:0072075)3.11286517
40hemidesmosome assembly (GO:0031581)3.08444958
41cytoskeletal anchoring at plasma membrane (GO:0007016)3.05358436
42cell-substrate junction assembly (GO:0007044)3.04998141
43negative regulation of catenin import into nucleus (GO:0035414)3.04544191
44cardiac cell development (GO:0055006)3.04509202
45bone trabecula formation (GO:0060346)3.04335616
46heart trabecula formation (GO:0060347)3.03997281
47regulation of axon extension involved in axon guidance (GO:0048841)3.03562880
48sarcomere organization (GO:0045214)3.00165096
49chondrocyte proliferation (GO:0035988)2.99723743
50negative regulation of cartilage development (GO:0061037)2.95658075
51branching involved in salivary gland morphogenesis (GO:0060445)2.95289294
52cell-substrate adherens junction assembly (GO:0007045)2.95277903
53focal adhesion assembly (GO:0048041)2.95277903
54notochord development (GO:0030903)2.95200090
55desmosome organization (GO:0002934)2.93206701
56camera-type eye morphogenesis (GO:0048593)2.93205384
57cardiac epithelial to mesenchymal transition (GO:0060317)2.92642894
58cardiac muscle cell development (GO:0055013)2.92374748
59Notch signaling involved in heart development (GO:0061314)2.91498539
60apical protein localization (GO:0045176)2.90042716
61epithelial cell differentiation involved in prostate gland development (GO:0060742)2.89651182
62kidney mesenchyme development (GO:0072074)2.88832698
63glomerular basement membrane development (GO:0032836)2.87490910
64trabecula formation (GO:0060343)2.86612915
65regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.86155238
66G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.86086114
67apoptotic process involved in morphogenesis (GO:0060561)2.83697141
68regulation of endothelial cell chemotaxis (GO:2001026)2.83360812
69collagen metabolic process (GO:0032963)2.83332553
70heart valve morphogenesis (GO:0003179)2.82635808
71regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.81698959
72cell proliferation involved in kidney development (GO:0072111)2.81607993
73non-canonical Wnt signaling pathway (GO:0035567)2.80475656
74negative regulation of axon extension involved in axon guidance (GO:0048843)2.78994139
75neural tube development (GO:0021915)2.76956481
76cardiac muscle cell proliferation (GO:0060038)2.76430108
77establishment of monopolar cell polarity (GO:0061162)2.75695574
78establishment or maintenance of monopolar cell polarity (GO:0061339)2.75695574
79endothelial cell morphogenesis (GO:0001886)2.74520158
80regulation of SMAD protein import into nucleus (GO:0060390)2.74331571
81negative regulation of cell fate specification (GO:0009996)2.72775320
82insulin-like growth factor receptor signaling pathway (GO:0048009)2.72689763
83collagen catabolic process (GO:0030574)2.72653578
84negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.72568535
85negative regulation of chondrocyte differentiation (GO:0032331)2.70177340
86ventricular trabecula myocardium morphogenesis (GO:0003222)2.69801400
87positive regulation of SMAD protein import into nucleus (GO:0060391)2.69602282
88pre-miRNA processing (GO:0031054)2.69579712
89negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.69400731
90establishment of tissue polarity (GO:0007164)2.68645925
91establishment of planar polarity (GO:0001736)2.68645925
92regulation of catenin import into nucleus (GO:0035412)2.68553072
93establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.67261682
94ventricular septum morphogenesis (GO:0060412)2.66943013
95outer ear morphogenesis (GO:0042473)2.66507483
96Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.66051642
97trabecula morphogenesis (GO:0061383)2.65786053
98dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.65448977
99patterning of blood vessels (GO:0001569)2.65358578
100regulation of axon guidance (GO:1902667)2.65153656
101collagen fibril organization (GO:0030199)2.64819860
102glomerulus development (GO:0032835)2.63817771
103skin morphogenesis (GO:0043589)2.63435709
104multicellular organismal macromolecule metabolic process (GO:0044259)2.63047911
105positive regulation of epithelial to mesenchymal transition (GO:0010718)2.62886094
106extracellular matrix disassembly (GO:0022617)2.62832503
107heart morphogenesis (GO:0003007)2.62829134
108somatic stem cell division (GO:0048103)2.61857799
109endodermal cell differentiation (GO:0035987)2.61625935
110cardiac right ventricle morphogenesis (GO:0003215)2.61556099
111heart valve formation (GO:0003188)2.60342364
112regulation of establishment of planar polarity (GO:0090175)2.60242110
113cardiac ventricle morphogenesis (GO:0003208)2.58888769
114vasculogenesis (GO:0001570)2.58677939
115regulation of cardioblast differentiation (GO:0051890)2.57365568
116dermatan sulfate metabolic process (GO:0030205)2.56901745
117regulation of heart morphogenesis (GO:2000826)2.56653877
118cell migration involved in sprouting angiogenesis (GO:0002042)2.56472129
119negative regulation of potassium ion transmembrane transport (GO:1901380)2.56432123
120eye morphogenesis (GO:0048592)2.54055887
121myelination in peripheral nervous system (GO:0022011)2.54015491
122peripheral nervous system axon ensheathment (GO:0032292)2.54015491
123anatomical structure regression (GO:0060033)2.53424104
124heart trabecula morphogenesis (GO:0061384)2.53228527
125cochlea morphogenesis (GO:0090103)2.52213008
126bundle of His cell to Purkinje myocyte communication (GO:0086069)2.51918138
127neuron projection extension involved in neuron projection guidance (GO:1902284)2.51572481
128axon extension involved in axon guidance (GO:0048846)2.51572481
129gastrulation with mouth forming second (GO:0001702)2.51362678
130actomyosin structure organization (GO:0031032)2.51287090
131regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.50899678
132gap junction assembly (GO:0016264)2.49899917
133positive regulation of catenin import into nucleus (GO:0035413)2.49769694
134asymmetric protein localization (GO:0008105)2.49477148
135negative regulation of embryonic development (GO:0045992)2.48803309
136multicellular organismal catabolic process (GO:0044243)2.46220315
137adherens junction organization (GO:0034332)2.46030112
138regulation of cell fate specification (GO:0042659)2.45876232
139multicellular organismal metabolic process (GO:0044236)2.45406784

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.18539969
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.32367540
3CLOCK_20551151_ChIP-Seq_293T_Human2.91006089
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.80371432
5STAT6_21828071_ChIP-Seq_BEAS2B_Human2.63832415
6EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.63453493
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.56843790
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.55861949
9ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.50638600
10SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.46266861
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.43414414
12* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.34904030
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.31802143
14ZNF263_19887448_ChIP-Seq_K562_Human2.26832304
15* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.20048420
16ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.18779826
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.16313043
18ZFP281_27345836_Chip-Seq_ESCs_Mouse2.07602788
19ERG_21242973_ChIP-ChIP_JURKAT_Human2.07255875
20E2F7_22180533_ChIP-Seq_HELA_Human2.03357487
21KDM2B_26808549_Chip-Seq_SUP-B15_Human2.01133341
22HIF1A_21447827_ChIP-Seq_MCF-7_Human1.98935366
23NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.97022401
24ELK3_25401928_ChIP-Seq_HUVEC_Human1.94267292
25* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.89523197
26* ESR2_21235772_ChIP-Seq_MCF-7_Human1.89383385
27TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.88376041
28PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.87639622
29EZH2_18974828_ChIP-Seq_MESCs_Mouse1.82217311
30RNF2_18974828_ChIP-Seq_MESCs_Mouse1.82217311
31TCF3_18692474_ChIP-Seq_MEFs_Mouse1.78718488
32RNF2_27304074_Chip-Seq_ESCs_Mouse1.78077433
33ESR1_21235772_ChIP-Seq_MCF-7_Human1.78052562
34EP300_21415370_ChIP-Seq_HL-1_Mouse1.77711472
35POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.74163225
36* KDM2B_26808549_Chip-Seq_DND41_Human1.74016189
37KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.69673417
38TBX20_22080862_ChIP-Seq_HEART_Mouse1.68456012
39TBX20_22328084_ChIP-Seq_HEART_Mouse1.68456012
40DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.68219034
41STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.68084374
42* KDM2B_26808549_Chip-Seq_K562_Human1.64722704
43SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.64019801
44* ISL1_27105846_Chip-Seq_CPCs_Mouse1.63536730
45SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.62125294
46EED_16625203_ChIP-ChIP_MESCs_Mouse1.61432539
47EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60347660
48RACK7_27058665_Chip-Seq_MCF-7_Human1.57602274
49TP53_20018659_ChIP-ChIP_R1E_Mouse1.55917119
50P300_27058665_Chip-Seq_ZR-75-30cells_Human1.55792238
51TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.52685423
52SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.50805546
53SOX9_24532713_ChIP-Seq_HFSC_Mouse1.50541071
54KDM2B_26808549_Chip-Seq_JURKAT_Human1.47921333
55MYC_22102868_ChIP-Seq_BL_Human1.46921064
56SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.46579069
57JARID2_20075857_ChIP-Seq_MESCs_Mouse1.44410697
58KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.43497274
59ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.43116282
60EZH2_27304074_Chip-Seq_ESCs_Mouse1.42549811
61UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.41853827
62SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.41358778
63TCF3_18692474_ChIP-Seq_MESCs_Mouse1.40048803
64LXR_22292898_ChIP-Seq_THP-1_Human1.39724833
65HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.39194094
66TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.38330971
67NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.38257526
68CTCF_27219007_Chip-Seq_Bcells_Human1.37221847
69TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.35519573
70TP63_19390658_ChIP-ChIP_HaCaT_Human1.35269592
71EZH2_27294783_Chip-Seq_ESCs_Mouse1.35262734
72TCF7_22412390_ChIP-Seq_EML_Mouse1.34316723
73SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.33770809
74* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.33400706
75ZNF217_24962896_ChIP-Seq_MCF-7_Human1.32198687
76ESR1_15608294_ChIP-ChIP_MCF-7_Human1.31287694
77SOX2_18555785_ChIP-Seq_MESCs_Mouse1.29175670
78TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28114829
79* KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.27826822
80* KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.27826822
81* KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.27826822
82KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.27748952
83CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.26293416
84ATF3_27146783_Chip-Seq_COLON_Human1.25344187
85* RUNX1_27514584_Chip-Seq_MCF-7_Human1.25067074
86MTF2_20144788_ChIP-Seq_MESCs_Mouse1.24465133
87* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.23964482
88SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.21663329
89ESR1_20079471_ChIP-ChIP_T-47D_Human1.21651094
90DROSHA_22980978_ChIP-Seq_HELA_Human1.21143915
91PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.20233486
92PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.16685528
93* TP53_22127205_ChIP-Seq_IMR90_Human1.16572334
94TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.15453039
95RBPJ_22232070_ChIP-Seq_NCS_Mouse1.15067429
96* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.14912932
97* UBF1/2_26484160_Chip-Seq_HMECs_Human1.14907612
98NFIB_24661679_ChIP-Seq_LUNG_Mouse1.14655275
99FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.14314312
100JARID2_20064375_ChIP-Seq_MESCs_Mouse1.13826645
101* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.12264160
102SMC3_22415368_ChIP-Seq_MEFs_Mouse1.12088359
103POU5F1_16518401_ChIP-PET_MESCs_Mouse1.10257876
104FOXO3_23340844_ChIP-Seq_DLD1_Human1.09915783
105RING1B_27294783_Chip-Seq_NPCs_Mouse1.09907557
106WT1_19549856_ChIP-ChIP_CCG9911_Human1.09889837
107NANOG_21062744_ChIP-ChIP_HESCs_Human1.09694190
108BRD4_25478319_ChIP-Seq_HGPS_Human1.09396981
109SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.09333667
110* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08450785
111TET1_21490601_ChIP-Seq_MESCs_Mouse1.08334462
112* CREB1_26743006_Chip-Seq_LNCaP_Human1.08067026
113* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.08059764
114SMC1_22415368_ChIP-Seq_MEFs_Mouse1.05844618
115KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04626459
116* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.02939453
117* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.02828420
118* RING1B_27294783_Chip-Seq_ESCs_Mouse1.02014053
119DNAJC2_21179169_ChIP-ChIP_NT2_Human1.01938606
120SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.01903710
121PPAR_26484153_Chip-Seq_NCI-H1993_Human1.01614256
122* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.01370555
123SMC4_20622854_ChIP-Seq_HELA_Human1.01323106
124MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.00760440
125ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.00757164
126TP53_23651856_ChIP-Seq_MEFs_Mouse1.00583077
127SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.00348136
128SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.00348136
129OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.00093853
130RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.99903286
131CJUN_26792858_Chip-Seq_BT549_Human0.99528536
132SA1_27219007_Chip-Seq_ERYTHROID_Human0.99134356
133FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.99100894
134TP63_22573176_ChIP-Seq_HFKS_Human0.98206020
135STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97891880
136SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97315234
137NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.96738660

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004272_abnormal_basement_membrane3.23627680
2MP0003705_abnormal_hypodermis_morpholog3.18126158
3MP0000579_abnormal_nail_morphology3.11514644
4MP0008438_abnormal_cutaneous_collagen3.01989499
5MP0000751_myopathy2.97161538
6MP0010030_abnormal_orbit_morphology2.84705695
7MP0005275_abnormal_skin_tensile2.59481924
8MP0003279_aneurysm2.50179205
9MP0004084_abnormal_cardiac_muscle2.43505563
10MP0005623_abnormal_meninges_morphology2.27493083
11MP0005257_abnormal_intraocular_pressure2.13517519
12MP0002837_dystrophic_cardiac_calcinosis2.13064937
13MP0000750_abnormal_muscle_regeneration2.09969133
14MP0004858_abnormal_nervous_system2.08680886
15MP0002254_reproductive_system_inflammat2.00400620
16MP0003566_abnormal_cell_adhesion1.93652698
17MP0009278_abnormal_bone_marrow1.87144033
18MP0003941_abnormal_skin_development1.84164106
19MP0000733_abnormal_muscle_development1.81728910
20MP0000537_abnormal_urethra_morphology1.74232479
21MP0005076_abnormal_cell_differentiation1.70927959
22MP0004087_abnormal_muscle_fiber1.70783002
23MP0002098_abnormal_vibrissa_morphology1.65628452
24MP0003385_abnormal_body_wall1.64990732
25MP0010368_abnormal_lymphatic_system1.63762472
26MP0005409_darkened_coat_color1.63133267
27MP0004233_abnormal_muscle_weight1.63044242
28MP0004215_abnormal_myocardial_fiber1.60757226
29MP0006138_congestive_heart_failure1.60600943
30MP0010630_abnormal_cardiac_muscle1.60038203
31MP0009053_abnormal_anal_canal1.59426131
32MP0004185_abnormal_adipocyte_glucose1.54352384
33MP0005330_cardiomyopathy1.53778385
34MP0005503_abnormal_tendon_morphology1.50763522
35MP0003283_abnormal_digestive_organ1.48564469
36MP0004381_abnormal_hair_follicle1.47776970
37MP0004036_abnormal_muscle_relaxation1.47624645
38MP0003453_abnormal_keratinocyte_physiol1.47466849
39MP0001849_ear_inflammation1.47079559
40MP0000749_muscle_degeneration1.46015456
41MP0000428_abnormal_craniofacial_morphol1.44740083
42MP0005501_abnormal_skin_physiology1.43123620
43* MP0000767_abnormal_smooth_muscle1.38656580
44MP0002249_abnormal_larynx_morphology1.35918864
45MP0001958_emphysema1.35647084
46MP0003828_pulmonary_edema1.35575282
47MP0010352_gastrointestinal_tract_polyps1.34791622
48MP0010234_abnormal_vibrissa_follicle1.34214331
49MP0008775_abnormal_heart_ventricle1.32807970
50MP0003935_abnormal_craniofacial_develop1.31245991
51MP0000462_abnormal_digestive_system1.29637781
52MP0000534_abnormal_ureter_morphology1.29537765
53MP0002234_abnormal_pharynx_morphology1.26956283
54MP0002108_abnormal_muscle_morphology1.26898616
55MP0005666_abnormal_adipose_tissue1.25392371
56MP0005508_abnormal_skeleton_morphology1.25215632
57* MP0002925_abnormal_cardiovascular_devel1.23994156
58MP0003123_paternal_imprinting1.23929526
59MP0002653_abnormal_ependyma_morphology1.23356493
60MP0005187_abnormal_penis_morphology1.23267243
61MP0003567_abnormal_fetal_cardiomyocyte1.22216953
62MP0002106_abnormal_muscle_physiology1.21540964
63MP0001544_abnormal_cardiovascular_syste1.21219984
64MP0005385_cardiovascular_system_phenoty1.21219984
65MP0000762_abnormal_tongue_morphology1.20788229
66MP0003115_abnormal_respiratory_system1.20626859
67MP0004197_abnormal_fetal_growth/weight/1.19955058
68MP0005375_adipose_tissue_phenotype1.19871021
69MP0002796_impaired_skin_barrier1.19413267
70MP0003119_abnormal_digestive_system1.18886494
71MP0002060_abnormal_skin_morphology1.18049717
72MP0003122_maternal_imprinting1.17741909
73MP0001879_abnormal_lymphatic_vessel1.17574466
74MP0000759_abnormal_skeletal_muscle1.17534866
75MP0002282_abnormal_trachea_morphology1.16682453
76MP0003942_abnormal_urinary_system1.16511152
77MP0000003_abnormal_adipose_tissue1.16347362
78MP0005620_abnormal_muscle_contractility1.15870435
79MP0002932_abnormal_joint_morphology1.14158933
80MP0004145_abnormal_muscle_electrophysio1.13429563
81MP0002972_abnormal_cardiac_muscle1.12149517
82MP0002116_abnormal_craniofacial_bone1.12052346
83MP0009250_abnormal_appendicular_skeleto1.11963789
84MP0000049_abnormal_middle_ear1.10608378
85MP0005369_muscle_phenotype1.09838539
86MP0006054_spinal_hemorrhage1.09229889
87MP0000383_abnormal_hair_follicle1.08923638
88MP0005023_abnormal_wound_healing1.08550347
89MP0000377_abnormal_hair_follicle1.08296645
90MP0002084_abnormal_developmental_patter1.08269721
91MP0010771_integument_phenotype1.07726557
92MP0009384_cardiac_valve_regurgitation1.06070521
93MP0009780_abnormal_chondrocyte_physiolo1.05733323
94MP0000266_abnormal_heart_morphology1.05638394
95MP0003137_abnormal_impulse_conducting1.04105294
96MP0002896_abnormal_bone_mineralization1.03350266
97MP0003091_abnormal_cell_migration1.02604053
98MP0002269_muscular_atrophy1.02145531
99MP0002085_abnormal_embryonic_tissue1.01634925
100MP0003755_abnormal_palate_morphology1.01387586
101MP0002127_abnormal_cardiovascular_syste1.00915757
102MP0005670_abnormal_white_adipose0.99226047
103MP0000467_abnormal_esophagus_morphology0.98824596
104MP0002088_abnormal_embryonic_growth/wei0.97949087
105* MP0002128_abnormal_blood_circulation0.97315271
106* MP0001614_abnormal_blood_vessel0.97176069
107MP0000432_abnormal_head_morphology0.96997295
108MP0003984_embryonic_growth_retardation0.96343894
109MP0002111_abnormal_tail_morphology0.96262274
110MP0002233_abnormal_nose_morphology0.96070157
111MP0000566_synostosis0.95739420
112MP0003937_abnormal_limbs/digits/tail_de0.95717304
113MP0002697_abnormal_eye_size0.95337572
114MP0001216_abnormal_epidermal_layer0.94265097
115MP0004130_abnormal_muscle_cell0.93948168
116MP0005595_abnormal_vascular_smooth0.93919933
117MP0001299_abnormal_eye_distance/0.93898982
118MP0005380_embryogenesis_phenotype0.93785034
119MP0001672_abnormal_embryogenesis/_devel0.93785034
120MP0002089_abnormal_postnatal_growth/wei0.92439962
121MP0001243_abnormal_dermal_layer0.92249234
122MP0000013_abnormal_adipose_tissue0.92194649
123MP0010678_abnormal_skin_adnexa0.90775204
124MP0004264_abnormal_extraembryonic_tissu0.89817885
125MP0005377_hearing/vestibular/ear_phenot0.89064613
126MP0003878_abnormal_ear_physiology0.89064613
127MP0002092_abnormal_eye_morphology0.87575735
128MP0009379_abnormal_foot_pigmentation0.80439856
129MP0000163_abnormal_cartilage_morphology0.76501203
130MP0005171_absent_coat_pigmentation0.74179747
131MP0001340_abnormal_eyelid_morphology0.71069733
132MP0003938_abnormal_ear_development0.70193442
133MP0009672_abnormal_birth_weight0.70190573
134MP0000678_abnormal_parathyroid_gland0.69575570
135MP0002295_abnormal_pulmonary_circulatio0.68097047
136MP0004133_heterotaxia0.67708814
137MP0009931_abnormal_skin_appearance0.67439865
138MP0003136_yellow_coat_color0.66093424

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.00097976
2Increased connective tissue (HP:0009025)3.94158759
3Ankle contracture (HP:0006466)3.90776161
4Premature rupture of membranes (HP:0001788)3.64507351
5Shallow orbits (HP:0000586)3.62388968
6Broad metatarsal (HP:0001783)3.62147158
7Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.61037105
8Short 4th metacarpal (HP:0010044)3.61037105
9Cerebral aneurysm (HP:0004944)3.55000796
10Muscle fiber splitting (HP:0003555)3.35063888
11Type 1 muscle fiber predominance (HP:0003803)3.32571330
12Abnormality of the 4th metacarpal (HP:0010012)3.25599427
13Right ventricular cardiomyopathy (HP:0011663)3.09502660
14Ventricular tachycardia (HP:0004756)2.93892440
15Aortic dissection (HP:0002647)2.90398153
16Mildly elevated creatine phosphokinase (HP:0008180)2.90197729
17Increased variability in muscle fiber diameter (HP:0003557)2.87524984
18Sudden death (HP:0001699)2.84303072
19Difficulty climbing stairs (HP:0003551)2.84047681
20Difficulty running (HP:0009046)2.82169209
21Abnormality of dentin (HP:0010299)2.73977940
22Aortic aneurysm (HP:0004942)2.72919334
23Abnormality of the calf musculature (HP:0001430)2.69676008
24Obstructive sleep apnea (HP:0002870)2.68752174
25Bladder diverticulum (HP:0000015)2.66075807
26Hyporeflexia of lower limbs (HP:0002600)2.62444704
27Atrophic scars (HP:0001075)2.60190242
28Spinal rigidity (HP:0003306)2.58247556
29Abnormality of skeletal muscle fiber size (HP:0012084)2.54396789
30Broad face (HP:0000283)2.51453244
31Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.50080123
32Turricephaly (HP:0000262)2.46277372
33Pterygium (HP:0001059)2.42353718
34Short hallux (HP:0010109)2.38059996
35Distal lower limb amyotrophy (HP:0008944)2.37668500
36Coronal craniosynostosis (HP:0004440)2.35424463
37Renal duplication (HP:0000075)2.33673472
38Hypoplastic ischia (HP:0003175)2.32094085
39Mitral valve prolapse (HP:0001634)2.30524428
40Ulnar bowing (HP:0003031)2.30357570
41Abnormality of nail color (HP:0100643)2.30308173
42Natal tooth (HP:0000695)2.29673577
43Blue sclerae (HP:0000592)2.29456205
44Aplasia involving bones of the extremities (HP:0009825)2.28234583
45Aplasia involving bones of the upper limbs (HP:0009823)2.28234583
46Aplasia of the phalanges of the hand (HP:0009802)2.28234583
47Advanced eruption of teeth (HP:0006288)2.27153739
48Aneurysm (HP:0002617)2.25755240
49Skull defect (HP:0001362)2.24032893
50Joint laxity (HP:0001388)2.22443885
51Cervical subluxation (HP:0003308)2.21823495
52Scapular winging (HP:0003691)2.21089128
53Arterial tortuosity (HP:0005116)2.20313942
54Vertebral arch anomaly (HP:0008438)2.20291143
55Vascular tortuosity (HP:0004948)2.19431995
56Aplasia/Hypoplasia of the hallux (HP:0008362)2.18986939
57Alopecia of scalp (HP:0002293)2.18545169
58Fragile skin (HP:0001030)2.18066107
59Dilatation of the ascending aorta (HP:0005111)2.17494157
60Thin ribs (HP:0000883)2.17316073
61Biconcave vertebral bodies (HP:0004586)2.16287161
62Hyperacusis (HP:0010780)2.15868883
63Wrist flexion contracture (HP:0001239)2.12320342
64Selective tooth agenesis (HP:0001592)2.11430041
65Mitral regurgitation (HP:0001653)2.09082092
66Ectopia lentis (HP:0001083)2.08532025
67Hyperextensible skin (HP:0000974)2.06490452
68Lymphangioma (HP:0100764)2.05399076
69Round ear (HP:0100830)2.04017071
70Lipoatrophy (HP:0100578)2.04014329
71Wormian bones (HP:0002645)2.01008500
72Mesomelia (HP:0003027)2.00569949
73Calf muscle hypertrophy (HP:0008981)2.00258671
74Abnormality of the ischium (HP:0003174)1.99681431
75Soft skin (HP:0000977)1.99362985
76Atrial fibrillation (HP:0005110)1.98457667
77Limb-girdle muscle weakness (HP:0003325)1.98313474
78Bowel diverticulosis (HP:0005222)1.96126202
79Morphological abnormality of the middle ear (HP:0008609)1.96118160
80Vitreoretinal degeneration (HP:0000655)1.95198940
81Infantile muscular hypotonia (HP:0008947)1.95143855
82Neonatal short-limb short stature (HP:0008921)1.95034676
83Supraventricular arrhythmia (HP:0005115)1.93717784
84Arnold-Chiari malformation (HP:0002308)1.93563943
85Follicular hyperkeratosis (HP:0007502)1.91053092
86Broad toe (HP:0001837)1.90743678
87Hypoplasia of the iris (HP:0007676)1.90358823
88Overgrowth (HP:0001548)1.89094239
89Primary atrial arrhythmia (HP:0001692)1.88179740
90Broad long bones (HP:0005622)1.87373680
91Fibroma (HP:0010614)1.87312730
92Pili torti (HP:0003777)1.86382401
93Disproportionate tall stature (HP:0001519)1.85067189
94Mesangial abnormality (HP:0001966)1.84316323
95Broad hallux (HP:0010055)1.84106012
96Fragile nails (HP:0001808)1.83922411
97Hip contracture (HP:0003273)1.83718317
98Lower limb amyotrophy (HP:0007210)1.82721496
99Genu recurvatum (HP:0002816)1.82394409
100Hypotrichosis (HP:0001006)1.81979955
101Aortic regurgitation (HP:0001659)1.81685920
102Renovascular hypertension (HP:0100817)1.81622546
103Abnormality of the calcaneus (HP:0008364)1.81084533
104Fibrous tissue neoplasm (HP:0012316)1.81056457
105Milia (HP:0001056)1.81031344
106Supraventricular tachycardia (HP:0004755)1.80835675
107Bicuspid aortic valve (HP:0001647)1.79552650
108Calcaneovalgus deformity (HP:0001848)1.78935068
109Laryngomalacia (HP:0001601)1.78305688
110Deviation of the hallux (HP:0010051)1.77289436
111Absent toe (HP:0010760)1.77138427
112Broad thumb (HP:0011304)1.77130935
113Preaxial foot polydactyly (HP:0001841)1.76914066
114EMG: myopathic abnormalities (HP:0003458)1.76066737
115Pulmonary artery stenosis (HP:0004415)1.75698302
116Thin bony cortex (HP:0002753)1.74695612
117Supernumerary ribs (HP:0005815)1.74302927
118Short phalanx of the thumb (HP:0009660)1.73998566
119Exercise-induced muscle cramps (HP:0003710)1.73001702
120Abnormality of molar (HP:0011077)1.72739596
121Abnormality of molar morphology (HP:0011070)1.72739596
122Rectal prolapse (HP:0002035)1.72027858
123Bronchomalacia (HP:0002780)1.71676243
124Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.71287112
125Abnormality of the distal phalanx of the thumb (HP:0009617)1.70033382
126Muscle hypertrophy of the lower extremities (HP:0008968)1.69979357
127Slender build (HP:0001533)1.69317506
128Abnormality of the diencephalon (HP:0010662)1.68337055
129Trigonocephaly (HP:0000243)1.68047615
130Breech presentation (HP:0001623)1.67674207
131Flat cornea (HP:0007720)1.66998513
132Tracheomalacia (HP:0002779)1.66636068
133Elfin facies (HP:0004428)1.66508056
134Overriding aorta (HP:0002623)1.66424194
135Broad phalanges of the hand (HP:0009768)1.66157586
136Abnormality of the left ventricular outflow tract (HP:0011103)1.66136039
137Subaortic stenosis (HP:0001682)1.66136039
138Broad phalanx (HP:0006009)1.65465220
139Broad finger (HP:0001500)1.65453110
140Limited hip movement (HP:0008800)1.64532168
141Hallux valgus (HP:0001822)1.64454073
142Limb-girdle muscle atrophy (HP:0003797)1.64388044
143Camptodactyly of toe (HP:0001836)1.63485035
144Adactyly (HP:0009776)1.63471802
145Abnormality of the pubic bones (HP:0003172)1.62978536
146Aplasia cutis congenita (HP:0001057)1.62714266
147Radial bowing (HP:0002986)1.62665344
148Neoplasm of the heart (HP:0100544)1.62639132
149Popliteal pterygium (HP:0009756)1.61566715
150Wide anterior fontanel (HP:0000260)1.61528990
151Abnormality of the salivary glands (HP:0010286)1.60690859
152Muscle fiber inclusion bodies (HP:0100299)1.60311979
153Absent eyelashes (HP:0000561)1.60053221
154Ependymoma (HP:0002888)1.59651364
155Down-sloping shoulders (HP:0200021)1.58338253
156Midline defect of the nose (HP:0004122)1.57456933

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN4.37464347
2PDGFRA3.60336507
3TRIB33.55248810
4PKN22.74360040
5EPHB22.66570542
6CDK122.52509617
7RIPK12.48809210
8LATS12.46948529
9EEF2K2.44328435
10MAP3K102.42584233
11MYLK2.41356104
12SMG12.38155806
13NTRK12.21222081
14DMPK2.21080200
15TIE12.13041706
16DDR22.00579345
17SIK11.99854983
18PAK21.68551209
19ICK1.68012185
20FGFR41.65176369
21LATS21.62701381
22EPHA21.60887631
23PTK61.57491038
24PASK1.57242010
25MAP3K61.51399604
26RPS6KB21.45375992
27PAK41.45117479
28FER1.40047993
29PDGFRB1.39144260
30MTOR1.39057561
31MAPK151.38846177
32CAMK1D1.38289871
33TGFBR11.28277242
34TGFBR21.21401017
35OBSCN1.18603036
36CAMK1G1.16869824
37NEK11.16752270
38FGFR11.14533262
39MST1R1.11631534
40ILK1.11506919
41BMX1.04751616
42LMTK21.03755877
43CDK61.02632143
44CDC42BPA1.01334046
45ERN10.99425070
46FGFR20.99211661
47EPHA30.97721038
48TESK10.97138360
49ROCK10.94377494
50EPHB10.91975720
51PTK20.88148036
52MET0.86452792
53LRRK20.85367198
54MAPK70.84931116
55PHKG20.82756802
56PHKG10.82756802
57MUSK0.82476439
58PRKD30.75029378
59KDR0.74849170
60BRD40.74549822
61STK38L0.74268365
62TYRO30.73849173
63NME10.73841988
64PAK30.71800542
65MAPKAPK30.71771794
66TSSK60.70455736
67ERBB20.69157494
68MAP3K70.68513849
69PRKD10.68229602
70FGFR30.67020987
71ALK0.65938048
72DAPK30.65760597
73NEK20.65139584
74KIT0.62851234
75ROCK20.61365747
76MAP2K20.60962869
77PDK40.60939798
78PDK30.60939798
79AKT20.60654451
80STK380.59495837
81NLK0.58796435
82CDK40.58568169
83STK30.57708607
84RPS6KC10.57582286
85RPS6KL10.57582286
86HIPK20.56297103
87CDC70.53210559
88RET0.51886703
89CAMK10.47216635
90MARK20.46751909
91RPS6KA60.46280658
92PNCK0.45627030
93CHUK0.44290676
94MAP3K30.43410012
95RPS6KA20.42313951
96CDK90.40798044
97STK100.40242630
98KSR10.40149511
99MAPK40.39081870
100MAP3K20.37143844
101TAF10.36705730
102RPS6KA10.36455926
103TTK0.36179884
104MAP3K80.36091063
105ADRBK10.35344209
106AURKB0.34120478
107CDK70.33624646
108PIK3CA0.33385312
109PDK20.33234912
110DYRK1B0.32632209
111PAK60.32459680
112PRKAA10.32357789
113CAMK2G0.32320985
114MAPK90.32166875
115TRPM70.32137103
116NEK60.31611838
117MKNK10.31494275
118STK240.31149192
119MAPK80.30766100
120MAPK10.30744253
121AKT10.30506403
122CAMK40.30457862
123PRKD20.30380823
124INSR0.29961395
125MAPK100.29685731
126CSNK1D0.29306402
127MAPKAPK20.29110134
128GSK3A0.29075941
129CAMK2B0.29058466
130PRKG20.28901149
131CAMK2D0.27412993
132MARK10.27172316
133PRKAA20.26607562
134NTRK20.26563846
135MAPK120.26343903
136WNK10.25569534

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052173.20085746
2ECM-receptor interaction_Homo sapiens_hsa045123.05986730
3Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.79774075
4Dilated cardiomyopathy_Homo sapiens_hsa054142.71485299
5Focal adhesion_Homo sapiens_hsa045102.63556541
6Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.52926436
7Adherens junction_Homo sapiens_hsa045202.42475799
8Hippo signaling pathway_Homo sapiens_hsa043902.42367537
9Hedgehog signaling pathway_Homo sapiens_hsa043402.30947010
10* Notch signaling pathway_Homo sapiens_hsa043302.15717797
11Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.13352128
12Proteoglycans in cancer_Homo sapiens_hsa052052.04150958
13Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.89727476
14Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.82360339
15Viral myocarditis_Homo sapiens_hsa054161.80018154
16* MicroRNAs in cancer_Homo sapiens_hsa052061.79912924
17Tight junction_Homo sapiens_hsa045301.75457226
18Small cell lung cancer_Homo sapiens_hsa052221.74764063
19TGF-beta signaling pathway_Homo sapiens_hsa043501.60732197
20Protein digestion and absorption_Homo sapiens_hsa049741.58773773
21Amoebiasis_Homo sapiens_hsa051461.53064336
22Central carbon metabolism in cancer_Homo sapiens_hsa052301.43599580
23Wnt signaling pathway_Homo sapiens_hsa043101.42077697
24Pathways in cancer_Homo sapiens_hsa052001.40707095
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.40474010
26AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.37258545
27Melanogenesis_Homo sapiens_hsa049161.34241718
28Axon guidance_Homo sapiens_hsa043601.31326888
29Lysine degradation_Homo sapiens_hsa003101.30169593
30Chronic myeloid leukemia_Homo sapiens_hsa052201.29680190
31Bladder cancer_Homo sapiens_hsa052191.29144950
32HTLV-I infection_Homo sapiens_hsa051661.22949455
33Leukocyte transendothelial migration_Homo sapiens_hsa046701.22474130
34Regulation of actin cytoskeleton_Homo sapiens_hsa048101.22206754
35PI3K-Akt signaling pathway_Homo sapiens_hsa041511.20288726
36Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.19077969
37Melanoma_Homo sapiens_hsa052181.18524336
38Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.16049941
39Rap1 signaling pathway_Homo sapiens_hsa040151.15413334
40Cyanoamino acid metabolism_Homo sapiens_hsa004601.14440941
41* Thyroid hormone signaling pathway_Homo sapiens_hsa049191.14187657
42Endometrial cancer_Homo sapiens_hsa052131.13355236
43Insulin resistance_Homo sapiens_hsa049311.12892523
44Gap junction_Homo sapiens_hsa045401.12192999
45cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09821020
46Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.05339727
47mTOR signaling pathway_Homo sapiens_hsa041501.03798523
48Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.02899304
49Colorectal cancer_Homo sapiens_hsa052101.02071677
50Glioma_Homo sapiens_hsa052141.02068762
51Prostate cancer_Homo sapiens_hsa052151.01908963
52AMPK signaling pathway_Homo sapiens_hsa041521.01086038
53Renal cell carcinoma_Homo sapiens_hsa052111.00018390
54Estrogen signaling pathway_Homo sapiens_hsa049150.97508562
55Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.96067930
56Fatty acid biosynthesis_Homo sapiens_hsa000610.95720549
57Vascular smooth muscle contraction_Homo sapiens_hsa042700.93567666
58Aldosterone synthesis and secretion_Homo sapiens_hsa049250.93519023
59Cardiac muscle contraction_Homo sapiens_hsa042600.91668971
60Insulin signaling pathway_Homo sapiens_hsa049100.91549304
61* Dorso-ventral axis formation_Homo sapiens_hsa043200.88949259
62Adipocytokine signaling pathway_Homo sapiens_hsa049200.87678350
63HIF-1 signaling pathway_Homo sapiens_hsa040660.86827277
64Thyroid cancer_Homo sapiens_hsa052160.85324816
65mRNA surveillance pathway_Homo sapiens_hsa030150.84052957
66Renin secretion_Homo sapiens_hsa049240.83622276
67Platelet activation_Homo sapiens_hsa046110.82467657
68Glucagon signaling pathway_Homo sapiens_hsa049220.77998797
69Longevity regulating pathway - mammal_Homo sapiens_hsa042110.77636820
70Spliceosome_Homo sapiens_hsa030400.73643617
71VEGF signaling pathway_Homo sapiens_hsa043700.70627076
72Oxytocin signaling pathway_Homo sapiens_hsa049210.69801381
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68948718
74Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.67881716
75Ovarian steroidogenesis_Homo sapiens_hsa049130.67145843
76Cell cycle_Homo sapiens_hsa041100.66573855
77Toxoplasmosis_Homo sapiens_hsa051450.66355597
78Pancreatic cancer_Homo sapiens_hsa052120.65773898
79MAPK signaling pathway_Homo sapiens_hsa040100.64713344
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62237684
81Fatty acid metabolism_Homo sapiens_hsa012120.61208782
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.60113958
83Non-small cell lung cancer_Homo sapiens_hsa052230.59997510
84Thyroid hormone synthesis_Homo sapiens_hsa049180.59335679
85p53 signaling pathway_Homo sapiens_hsa041150.58935065
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.58713402
87Acute myeloid leukemia_Homo sapiens_hsa052210.57980788
88Ras signaling pathway_Homo sapiens_hsa040140.57361078
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56677623
90cAMP signaling pathway_Homo sapiens_hsa040240.55014005
91Type II diabetes mellitus_Homo sapiens_hsa049300.54146052
92Long-term depression_Homo sapiens_hsa047300.53913897
93Glycosaminoglycan degradation_Homo sapiens_hsa005310.53491909
94Viral carcinogenesis_Homo sapiens_hsa052030.52289608
95Carbon metabolism_Homo sapiens_hsa012000.51497691
96FoxO signaling pathway_Homo sapiens_hsa040680.48900399
97RNA transport_Homo sapiens_hsa030130.48645445
98Bile secretion_Homo sapiens_hsa049760.47430622
99Inositol phosphate metabolism_Homo sapiens_hsa005620.47227844
100GnRH signaling pathway_Homo sapiens_hsa049120.45883689
101Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.45680824
102Circadian entrainment_Homo sapiens_hsa047130.44853325
103PPAR signaling pathway_Homo sapiens_hsa033200.44644489
104ErbB signaling pathway_Homo sapiens_hsa040120.44437753
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43773187
106Prolactin signaling pathway_Homo sapiens_hsa049170.42161485
107Fatty acid degradation_Homo sapiens_hsa000710.41973284
108Cocaine addiction_Homo sapiens_hsa050300.41396185
109Salivary secretion_Homo sapiens_hsa049700.40995177
110Choline metabolism in cancer_Homo sapiens_hsa052310.39760127
111Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39747854
112Oocyte meiosis_Homo sapiens_hsa041140.39116156
113Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37117705
114Circadian rhythm_Homo sapiens_hsa047100.36995372
115Prion diseases_Homo sapiens_hsa050200.36321563
116Gastric acid secretion_Homo sapiens_hsa049710.36120330
117Calcium signaling pathway_Homo sapiens_hsa040200.35609579
118Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.34318964
119Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.34070440
120Sulfur relay system_Homo sapiens_hsa041220.32085042
121Galactose metabolism_Homo sapiens_hsa000520.31206737

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