NOTCH2NL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of molecule of bacterial origin (GO:0032490)4.30222149
2protein K11-linked deubiquitination (GO:0035871)4.14908163
3cellular response to ethanol (GO:0071361)4.00086381
4microglial cell activation (GO:0001774)3.96289089
5monoubiquitinated protein deubiquitination (GO:0035520)3.77155253
6phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.73520148
7positive regulation of gamma-delta T cell activation (GO:0046645)3.61933538
8regulation of B cell receptor signaling pathway (GO:0050855)3.43253513
9interleukin-6-mediated signaling pathway (GO:0070102)3.41987549
10hepatocyte apoptotic process (GO:0097284)3.36408720
11interkinetic nuclear migration (GO:0022027)3.35058176
12protein targeting to lysosome (GO:0006622)3.27878437
13establishment of protein localization to vacuole (GO:0072666)3.27878437
14protein targeting to vacuole (GO:0006623)3.27878437
15establishment of protein localization to Golgi (GO:0072600)3.26967588
16macrophage activation involved in immune response (GO:0002281)3.25592488
17mature B cell differentiation involved in immune response (GO:0002313)3.24675888
18histone mRNA catabolic process (GO:0071044)3.21666670
19positive regulation of mast cell activation involved in immune response (GO:0033008)3.11982795
20positive regulation of mast cell degranulation (GO:0043306)3.11982795
21positive regulation of mast cell activation (GO:0033005)3.11917130
22neutrophil mediated immunity (GO:0002446)3.11068186
23positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.10187046
24mature B cell differentiation (GO:0002335)3.09422426
25cellular extravasation (GO:0045123)3.07160196
26macrophage activation (GO:0042116)3.04411728
27negative regulation of complement activation (GO:0045916)3.02913184
28positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.00658886
29protein K63-linked deubiquitination (GO:0070536)2.99543538
30protein K48-linked deubiquitination (GO:0071108)2.97479647
31positive regulation of granulocyte differentiation (GO:0030854)2.96804911
32regulation of gamma-delta T cell activation (GO:0046643)2.92568553
33detection of external biotic stimulus (GO:0098581)2.91198846
34neutrophil activation involved in immune response (GO:0002283)2.88453353
35regulation of mast cell activation (GO:0033003)2.86441035
36positive regulation by symbiont of host defense response (GO:0052509)2.83579748
37modulation by symbiont of host defense response (GO:0052031)2.83579748
38modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.83579748
39modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.83579748
40positive regulation by organism of defense response of other organism involved in symbiotic interact2.83579748
41modulation by symbiont of host immune response (GO:0052553)2.83579748
42regulation of mast cell activation involved in immune response (GO:0033006)2.81246132
43regulation of gamma-delta T cell differentiation (GO:0045586)2.81082512
44fibroblast migration (GO:0010761)2.79851666
45response to peptidoglycan (GO:0032494)2.79168597
46regulation of interleukin-12 biosynthetic process (GO:0045075)2.78313073
47regulation of establishment of cell polarity (GO:2000114)2.77442519
48retrograde transport, vesicle recycling within Golgi (GO:0000301)2.77213580
49definitive hemopoiesis (GO:0060216)2.75349846
50lipid translocation (GO:0034204)2.74202975
51phospholipid translocation (GO:0045332)2.74202975
52regulation of pigment cell differentiation (GO:0050932)2.72815643
53regulation of hypersensitivity (GO:0002883)2.68723066
54negative regulation of B cell proliferation (GO:0030889)2.66356733
55positive regulation of developmental pigmentation (GO:0048087)2.65850116
56protein targeting to Golgi (GO:0000042)2.63978735
57negative regulation of protein activation cascade (GO:2000258)2.63438825
58negative regulation of interleukin-12 production (GO:0032695)2.61079379
59negative regulation of interleukin-8 production (GO:0032717)2.60808821
60regulation of mast cell degranulation (GO:0043304)2.59235727
61B cell receptor signaling pathway (GO:0050853)2.56902782
62regulation of germinal center formation (GO:0002634)2.54400672
63regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.54080721
64myeloid leukocyte mediated immunity (GO:0002444)2.52023782
65iron ion import (GO:0097286)2.51471586
66positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.47191050
67regulation of necroptotic process (GO:0060544)2.46169815
68T-helper 1 type immune response (GO:0042088)2.45572551
69regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.45345402
70positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.45309193
71positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.44153932
72negative regulation of humoral immune response (GO:0002921)2.43871808
73myeloid cell activation involved in immune response (GO:0002275)2.43313647
74detection of biotic stimulus (GO:0009595)2.42938153
75histone H3-K4 trimethylation (GO:0080182)2.41697618
76response to host immune response (GO:0052572)2.41666045
77response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.41666045
78early endosome to late endosome transport (GO:0045022)2.41180154
79antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.38796023
80negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.36684425
81regulation of interferon-beta biosynthetic process (GO:0045357)2.36091117
82germinal center formation (GO:0002467)2.33725768
83negative regulation of interleukin-17 production (GO:0032700)2.32974128
84detection of other organism (GO:0098543)2.32534308
85response to host (GO:0075136)2.31914463
86response to host defenses (GO:0052200)2.31914463
87response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.31914463
88histone H3-K36 demethylation (GO:0070544)2.31712997
89gonadal mesoderm development (GO:0007506)2.31207056
90regulation of B cell proliferation (GO:0030888)2.30112489
91neutrophil activation (GO:0042119)2.28647659
92regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.28071336
93regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.27333266
94positive regulation of chemokine secretion (GO:0090197)2.26630158
95neural tube formation (GO:0001841)2.26504776
96regulation of establishment or maintenance of cell polarity (GO:0032878)2.25374599
97positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.24599781
98regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.23688905
99protein localization to vacuole (GO:0072665)2.23535313
100protein localization to lysosome (GO:0061462)2.23535313

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.76575247
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.66124004
3SMAD_19615063_ChIP-ChIP_OVARY_Human3.61274169
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.69974850
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.66023740
6* ESR1_20079471_ChIP-ChIP_T-47D_Human2.63281060
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.58216205
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.45094771
9SCL_19346495_ChIP-Seq_HPC-7_Human2.28517617
10GBX2_23144817_ChIP-Seq_PC3_Human2.25620178
11Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.21618406
12TP53_16413492_ChIP-PET_HCT116_Human2.06017270
13IRF8_21731497_ChIP-ChIP_J774_Mouse1.94881341
14POU3F2_20337985_ChIP-ChIP_501MEL_Human1.92269904
15AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.92072967
16IRF8_27001747_Chip-Seq_BMDM_Mouse1.89374039
17CDX2_19796622_ChIP-Seq_MESCs_Mouse1.89338198
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.88722124
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.88026325
20ZNF217_24962896_ChIP-Seq_MCF-7_Human1.85974268
21RUNX_20019798_ChIP-Seq_JUKART_Human1.79921435
22MYB_21317192_ChIP-Seq_ERMYB_Mouse1.78864091
23VDR_24787735_ChIP-Seq_THP-1_Human1.70996533
24MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.70108227
25BP1_19119308_ChIP-ChIP_Hs578T_Human1.70041002
26TAF15_26573619_Chip-Seq_HEK293_Human1.68041840
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.64551754
28CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.64393748
29ER_23166858_ChIP-Seq_MCF-7_Human1.61584327
30GATA1_22025678_ChIP-Seq_K562_Human1.59154734
31STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.58861991
32AHR_22903824_ChIP-Seq_MCF-7_Human1.58114053
33GATA2_21666600_ChIP-Seq_HMVEC_Human1.56725070
34RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54153243
35PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.53978721
36NRF2_20460467_ChIP-Seq_MEFs_Mouse1.50271415
37NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.50271415
38* CJUN_26792858_Chip-Seq_BT549_Human1.49506901
39PIAS1_25552417_ChIP-Seq_VCAP_Human1.48105084
40PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.47435010
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.46136140
42NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.44894985
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44589033
44IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.41191657
45CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.39439880
46EGR1_23403033_ChIP-Seq_LIVER_Mouse1.38605279
47EZH2_27294783_Chip-Seq_NPCs_Mouse1.38397229
48ARNT_22903824_ChIP-Seq_MCF-7_Human1.38311995
49FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.36954187
50GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.35649815
51* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.33991123
52SMAD4_21799915_ChIP-Seq_A2780_Human1.33275900
53STAT3_23295773_ChIP-Seq_U87_Human1.32450666
54IGF1R_20145208_ChIP-Seq_DFB_Human1.31543157
55* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.31381156
56BRD4_25478319_ChIP-Seq_HGPS_Human1.29881596
57CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.29383072
58* MYB_26560356_Chip-Seq_TH2_Human1.28915028
59ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.28223149
60ZFP57_27257070_Chip-Seq_ESCs_Mouse1.27835176
61SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24860061
62AR_21572438_ChIP-Seq_LNCaP_Human1.24232132
63JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22706985
64TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.21802574
65* SPI1_23127762_ChIP-Seq_K562_Human1.18405216
66NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.18281252
67VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.18169595
68GATA3_26560356_Chip-Seq_TH2_Human1.17335175
69PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.16888719
70NFE2_27457419_Chip-Seq_LIVER_Mouse1.16841741
71* TP63_23658742_ChIP-Seq_EP156T_Human1.16839496
72GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16539012
73GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14613673
74P300_19829295_ChIP-Seq_ESCs_Human1.14356497
75PCGF2_27294783_Chip-Seq_ESCs_Mouse1.14291181
76CBP_20019798_ChIP-Seq_JUKART_Human1.13734966
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.13734966
78OCT4_21477851_ChIP-Seq_ESCs_Mouse1.12847827
79* TCF4_23295773_ChIP-Seq_U87_Human1.11853518
80NANOG_18555785_Chip-Seq_ESCs_Mouse1.11831181
81CDX2_22108803_ChIP-Seq_LS180_Human1.11334058
82OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11297779
83CRX_20693478_ChIP-Seq_RETINA_Mouse1.11227225
84FLI1_21867929_ChIP-Seq_TH2_Mouse1.11106849
85* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10557469
86UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10425626
87* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10393432
88SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10333032
89NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.10177940
90E2F1_18555785_Chip-Seq_ESCs_Mouse1.09389011
91STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.09154136
92EWS_26573619_Chip-Seq_HEK293_Human1.08286886
93MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07677204
94BCAT_22108803_ChIP-Seq_LS180_Human1.05695879
95SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05038603
96* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.04265285
97* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.04265285
98TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04153836
99GATA3_27048872_Chip-Seq_THYMUS_Human1.03640298
100* MYB_26560356_Chip-Seq_TH1_Human1.01549160

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.24634815
2MP0003724_increased_susceptibility_to3.16784254
3MP0001835_abnormal_antigen_presentation2.96587557
4MP0008057_abnormal_DNA_replication2.46603000
5MP0000465_gastrointestinal_hemorrhage2.23696451
6MP0003656_abnormal_erythrocyte_physiolo2.21619668
7MP0000383_abnormal_hair_follicle2.16861475
8MP0003950_abnormal_plasma_membrane2.16632335
9MP0002009_preneoplasia2.12669512
10MP0005464_abnormal_platelet_physiology2.02639527
11MP0003763_abnormal_thymus_physiology2.00948685
12MP0006054_spinal_hemorrhage2.00882228
13MP0001800_abnormal_humoral_immune1.88207843
14MP0005275_abnormal_skin_tensile1.87927276
15MP0004883_abnormal_blood_vessel1.83326434
16MP0005174_abnormal_tail_pigmentation1.83091706
17MP0002419_abnormal_innate_immunity1.82165083
18MP0000015_abnormal_ear_pigmentation1.82165033
19MP0003828_pulmonary_edema1.72426255
20MP0005164_abnormal_response_to1.71513585
21MP0005397_hematopoietic_system_phenotyp1.69149974
22MP0001545_abnormal_hematopoietic_system1.69149974
23MP0010678_abnormal_skin_adnexa1.68550506
24MP0002452_abnormal_antigen_presenting1.66602236
25MP0002166_altered_tumor_susceptibility1.65794765
26MP0005310_abnormal_salivary_gland1.65433401
27MP0003045_fibrosis1.64224309
28MP0000427_abnormal_hair_cycle1.62612452
29MP0000371_diluted_coat_color1.62260621
30MP0003191_abnormal_cellular_cholesterol1.58876249
31MP0002148_abnormal_hypersensitivity_rea1.57538346
32MP0002723_abnormal_immune_serum1.56513804
33MP0004381_abnormal_hair_follicle1.52594963
34MP0003300_gastrointestinal_ulcer1.51472583
35MP0009764_decreased_sensitivity_to1.49961662
36MP0003303_peritoneal_inflammation1.48472946
37MP0003183_abnormal_peptide_metabolism1.44906415
38MP0001958_emphysema1.39243107
39MP0005000_abnormal_immune_tolerance1.35506026
40MP0008260_abnormal_autophagy1.35503802
41MP0005025_abnormal_response_to1.34936414
42MP0002405_respiratory_system_inflammati1.32650700
43MP0002420_abnormal_adaptive_immunity1.31785067
44MP0001819_abnormal_immune_cell1.31610444
45MP0003195_calcinosis1.31598296
46MP0004808_abnormal_hematopoietic_stem1.30375985
47MP0002168_other_aberrant_phenotype1.30255506
48MP0001851_eye_inflammation1.28132345
49MP0000685_abnormal_immune_system1.27463821
50MP0003436_decreased_susceptibility_to1.27334058
51MP0003091_abnormal_cell_migration1.22930291
52MP0009785_altered_susceptibility_to1.22678508
53MP0005408_hypopigmentation1.22575669
54MP0005075_abnormal_melanosome_morpholog1.20180601
55MP0003172_abnormal_lysosome_physiology1.19076733
56MP0009697_abnormal_copulation1.18615064
57MP0008004_abnormal_stomach_pH1.18343428
58MP0001853_heart_inflammation1.18338327
59MP0002332_abnormal_exercise_endurance1.18185313
60MP0005387_immune_system_phenotype1.16215417
61MP0001790_abnormal_immune_system1.16215417
62MP0003252_abnormal_bile_duct1.14850992
63MP0002396_abnormal_hematopoietic_system1.14562427
64MP0004484_altered_response_of1.11416301
65MP0002006_tumorigenesis1.11074286
66MP0000716_abnormal_immune_system1.09843093
67MP0002998_abnormal_bone_remodeling1.09726792
68MP0002398_abnormal_bone_marrow1.07672835
69MP0008438_abnormal_cutaneous_collagen1.06856770
70MP0004947_skin_inflammation1.05774651
71MP0009278_abnormal_bone_marrow1.04020353
72MP0006082_CNS_inflammation1.03963023
73MP0005647_abnormal_sex_gland1.03100651
74MP0001845_abnormal_inflammatory_respons1.03067858
75MP0000249_abnormal_blood_vessel1.00795917
76MP0000689_abnormal_spleen_morphology0.99161732
77MP0002095_abnormal_skin_pigmentation0.93898703
78MP0005171_absent_coat_pigmentation0.91652056
79MP0001533_abnormal_skeleton_physiology0.91584212
80MP0005376_homeostasis/metabolism_phenot0.91460089
81MP0002928_abnormal_bile_duct0.89059199
82MP0002722_abnormal_immune_system0.88953723
83MP0010155_abnormal_intestine_physiology0.87405686
84MP0005671_abnormal_response_to0.85232870
85MP0005058_abnormal_lysosome_morphology0.83040057
86MP0010352_gastrointestinal_tract_polyps0.81585946
87MP0004043_abnormal_pH_regulation0.80578656
88MP0005248_abnormal_Harderian_gland0.79755080
89MP0005670_abnormal_white_adipose0.79323721
90MP0002429_abnormal_blood_cell0.77982973
91MP0008469_abnormal_protein_level0.77978618
92MP0001873_stomach_inflammation0.77631848
93MP0004084_abnormal_cardiac_muscle0.77100047
94MP0005595_abnormal_vascular_smooth0.76479528
95MP0003279_aneurysm0.76122849
96MP0000767_abnormal_smooth_muscle0.73462129
97MP0009115_abnormal_fat_cell0.72422579
98MP0000230_abnormal_systemic_arterial0.70961757
99MP0009763_increased_sensitivity_to0.70481967
100MP0003690_abnormal_glial_cell0.68042717

Predicted human phenotypes

RankGene SetZ-score
1Absent frontal sinuses (HP:0002688)3.85807346
2T lymphocytopenia (HP:0005403)3.29051643
3Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)3.20305296
4Abnormality of T cell number (HP:0011839)3.17462580
5Gingival bleeding (HP:0000225)3.16613470
6Recurrent bacterial skin infections (HP:0005406)3.00825887
7Osteolytic defects of the phalanges of the hand (HP:0009771)2.91027084
8Osteolytic defects of the hand bones (HP:0009699)2.91027084
9Periodontitis (HP:0000704)2.90015831
10Genetic anticipation (HP:0003743)2.88635399
11Prolonged bleeding time (HP:0003010)2.81842578
12Fair hair (HP:0002286)2.73455415
13Abnormality of the frontal sinuses (HP:0002687)2.71751672
14Retrobulbar optic neuritis (HP:0100654)2.69287370
15Optic neuritis (HP:0100653)2.69287370
16Epistaxis (HP:0000421)2.66746295
17Orchitis (HP:0100796)2.65491890
18Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.62840220
19Recurrent fungal infections (HP:0002841)2.61873618
20Spondylolisthesis (HP:0003302)2.61280344
21Abnormality of the axillary hair (HP:0100134)2.60104504
22Abnormality of secondary sexual hair (HP:0009888)2.60104504
23Recurrent abscess formation (HP:0002722)2.59948984
24Pulmonary artery stenosis (HP:0004415)2.57262465
25Aortic aneurysm (HP:0004942)2.56542166
26Myositis (HP:0100614)2.56028690
27Mitral stenosis (HP:0001718)2.53267765
28Chronic mucocutaneous candidiasis (HP:0002728)2.48355067
29Recurrent cutaneous fungal infections (HP:0011370)2.48355067
30Increased neuronal autofluorescent lipopigment (HP:0002074)2.47912813
31Spinal cord lesions (HP:0100561)2.44505872
32Syringomyelia (HP:0003396)2.44505872
33Increased cerebral lipofuscin (HP:0011813)2.41290922
34Generalized hypopigmentation of hair (HP:0011358)2.39539061
35Acute myeloid leukemia (HP:0004808)2.38105813
36Stomach cancer (HP:0012126)2.38066471
37Papillary thyroid carcinoma (HP:0002895)2.37661237
38Eczematoid dermatitis (HP:0000976)2.32274783
39Eosinophilia (HP:0001880)2.31007896
40Abnormality of the vasculature of the conjunctiva (HP:0008054)2.29881847
41Hematochezia (HP:0002573)2.27189739
42Prostate neoplasm (HP:0100787)2.27008254
43Autoimmune thrombocytopenia (HP:0001973)2.24838114
44Widely spaced teeth (HP:0000687)2.23719867
45Clumsiness (HP:0002312)2.23599223
46Hyperventilation (HP:0002883)2.23115397
47Deformed sella turcica (HP:0002681)2.22519168
48Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.21138696
49Abnormality of glycolipid metabolism (HP:0010969)2.19054858
50Abnormality of liposaccharide metabolism (HP:0010968)2.19054858
51Abnormality of glycosphingolipid metabolism (HP:0004343)2.19054858
52Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.18857694
53Narrow palate (HP:0000189)2.17820691
54Recurrent bronchitis (HP:0002837)2.15605203
55Autoimmune hemolytic anemia (HP:0001890)2.15487786
56Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.14416218
57Abnormal delayed hypersensitivity skin test (HP:0002963)2.14183635
58Thyroiditis (HP:0100646)2.12932666
59Recurrent skin infections (HP:0001581)2.12398677
60Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.11976846
61Neoplasm of the tracheobronchial system (HP:0100552)2.11178624
62Conjunctival telangiectasia (HP:0000524)2.11071109
63Abnormality of the sella turcica (HP:0002679)2.10884368
64Stomatitis (HP:0010280)2.10462417
65Colitis (HP:0002583)2.09646959
66Subacute progressive viral hepatitis (HP:0006572)2.08801760
67Chest pain (HP:0100749)2.07618236
68Large earlobe (HP:0009748)2.07260284
69Abnormality of the prostate (HP:0008775)2.05659397
70Ectropion (HP:0000656)2.05314571
71Increased mean platelet volume (HP:0011877)2.03822707
72Recurrent viral infections (HP:0004429)2.03679635
73Portal hypertension (HP:0001409)2.02613034
74Elevated erythrocyte sedimentation rate (HP:0003565)2.02530454
75Aortic dissection (HP:0002647)2.00874068
76Gingivitis (HP:0000230)1.99920411
77Facial diplegia (HP:0001349)1.99513898
78Mediastinal lymphadenopathy (HP:0100721)1.99357009
79Spontaneous hematomas (HP:0007420)1.99173997
80Keratoconjunctivitis sicca (HP:0001097)1.98969596
81Arterial thrombosis (HP:0004420)1.98270346
82Glucose intolerance (HP:0000833)1.97827144
83Hemoptysis (HP:0002105)1.97496544
84Gaze-evoked nystagmus (HP:0000640)1.96464900
85Menorrhagia (HP:0000132)1.92319280
86Keratoconjunctivitis (HP:0001096)1.91839208
87Abnormality of the pericardium (HP:0001697)1.91664677
88Absent speech (HP:0001344)1.90102666
89Pulmonary infiltrates (HP:0002113)1.89855001
90Gangrene (HP:0100758)1.89425387
91Abnormal platelet volume (HP:0011876)1.88909109
92Leukocytosis (HP:0001974)1.87169239
93Granulocytopenia (HP:0001913)1.84320331
94Viral hepatitis (HP:0006562)1.83787742
95Prominent nose (HP:0000448)1.83195394
96Abnormality of the epiphyses of the hand (HP:0005924)1.81847411
97Macular degeneration (HP:0000608)1.81837367
98Metaphyseal dysplasia (HP:0100255)1.80518652
99Anhidrosis (HP:0000970)1.80191934
100Abnormality of T cells (HP:0002843)1.80176430

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.84814804
2BLK3.48813972
3TAOK33.46950865
4BMPR1B2.82131507
5AKT32.71270818
6PIK3CG2.54680355
7BMPR21.99504989
8IKBKE1.91558616
9ACVR1B1.76979270
10IRAK11.75208917
11SGK21.67896929
12TXK1.61547377
13FLT31.59729462
14KIT1.56713495
15MAP3K141.53183722
16IKBKB1.50017095
17NEK91.49689059
18LATS11.47816879
19TRPM71.45996305
20PTK2B1.45313651
21JAK11.44231457
22GRK61.42009113
23PIK3CA1.39690018
24TEC1.35562524
25MARK31.32214724
26NUAK11.31054123
27JAK31.30430277
28SYK1.27580247
29BTK1.23016258
30MAP2K31.19563943
31GRK71.19506072
32TGFBR21.18290235
33TYK21.17854889
34MAP4K21.17512810
35CSF1R1.16659875
36ZAP701.14173631
37SGK31.11930539
38CDK121.09686788
39MELK1.07866840
40CSK1.07790834
41NLK1.05076731
42CAMK1D1.00598439
43CHUK0.98932703
44STK38L0.98342743
45MYLK0.97199829
46MAPK70.94866266
47BRSK20.94256543
48CAMK1G0.93308679
49HCK0.92729708
50CAMKK20.89944380
51PDGFRB0.89419565
52MAP3K30.88125988
53FER0.87827727
54CSNK1A1L0.85450099
55STK380.83711686
56ERBB20.82878085
57LCK0.81473769
58ADRBK10.79392154
59WNK10.79233067
60LYN0.75767279
61MAP3K20.75197118
62JAK20.74454868
63FGR0.74229072
64EPHA30.72349268
65MAP3K70.71821171
66BRD40.71010257
67SGK4940.70967531
68SGK2230.70967531
69IRAK40.69739978
70EGFR0.69221366
71TBK10.68044037
72STK240.65515234
73PIM10.61720611
74HIPK20.60242067
75CDK60.58171796
76FES0.57591134
77RIPK40.57324011
78ABL10.56460773
79PRKAA20.55529853
80MAP3K130.54506532
81ADRBK20.54229767
82TNK20.54034774
83ITK0.53174129
84MATK0.52951418
85INSRR0.52872999
86MARK20.52306796
87YES10.51905673
88NEK60.51627632
89GRK50.49849172
90PLK20.49593731
91FGFR30.49344301
92STK30.49025767
93MST40.48894339
94DYRK30.48532230
95MAP3K10.48253358
96GRK10.46237470
97MAPK110.46226696
98MET0.43780641
99PIM20.43208697
100MAP3K60.42109764

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051502.52820897
2Asthma_Homo sapiens_hsa053102.45086130
3Leishmaniasis_Homo sapiens_hsa051402.17764838
4Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.16425839
5Graft-versus-host disease_Homo sapiens_hsa053322.02506994
6Allograft rejection_Homo sapiens_hsa053301.92860706
7Intestinal immune network for IgA production_Homo sapiens_hsa046721.92122460
8Osteoclast differentiation_Homo sapiens_hsa043801.76120589
9Autoimmune thyroid disease_Homo sapiens_hsa053201.76032888
10NOD-like receptor signaling pathway_Homo sapiens_hsa046211.75796721
11RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.71976508
12NF-kappa B signaling pathway_Homo sapiens_hsa040641.68383502
13Platelet activation_Homo sapiens_hsa046111.67403346
14Tuberculosis_Homo sapiens_hsa051521.62883970
15Toll-like receptor signaling pathway_Homo sapiens_hsa046201.58559073
16Dorso-ventral axis formation_Homo sapiens_hsa043201.52237478
17Malaria_Homo sapiens_hsa051441.51306241
18TNF signaling pathway_Homo sapiens_hsa046681.45097881
19Toxoplasmosis_Homo sapiens_hsa051451.43704698
20Jak-STAT signaling pathway_Homo sapiens_hsa046301.42533714
21Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.42525900
22B cell receptor signaling pathway_Homo sapiens_hsa046621.40127897
23Hematopoietic cell lineage_Homo sapiens_hsa046401.38375743
24Glycosaminoglycan degradation_Homo sapiens_hsa005311.21964037
25Influenza A_Homo sapiens_hsa051641.21613739
26ABC transporters_Homo sapiens_hsa020101.18314082
27SNARE interactions in vesicular transport_Homo sapiens_hsa041301.17064027
28Rheumatoid arthritis_Homo sapiens_hsa053231.13971853
29Measles_Homo sapiens_hsa051621.10699323
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.09614686
31Legionellosis_Homo sapiens_hsa051341.09344261
32Primary bile acid biosynthesis_Homo sapiens_hsa001201.08633191
33Circadian rhythm_Homo sapiens_hsa047101.07011790
34Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.06397630
35Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.05005638
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.01221526
37FoxO signaling pathway_Homo sapiens_hsa040681.00819327
38Viral myocarditis_Homo sapiens_hsa054161.00283484
39Complement and coagulation cascades_Homo sapiens_hsa046100.99502901
40Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.98381906
41Acute myeloid leukemia_Homo sapiens_hsa052210.96303724
42Lysosome_Homo sapiens_hsa041420.96216073
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.94839052
44Type I diabetes mellitus_Homo sapiens_hsa049400.94225880
45Non-small cell lung cancer_Homo sapiens_hsa052230.91540463
46T cell receptor signaling pathway_Homo sapiens_hsa046600.91510078
47Transcriptional misregulation in cancer_Homo sapiens_hsa052020.91245487
48Regulation of autophagy_Homo sapiens_hsa041400.89669128
49Herpes simplex infection_Homo sapiens_hsa051680.87030558
50Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87000555
51Arachidonic acid metabolism_Homo sapiens_hsa005900.86192173
52Hepatitis B_Homo sapiens_hsa051610.85312450
53Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.84794854
54Antigen processing and presentation_Homo sapiens_hsa046120.82840608
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.81814741
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80084978
57Pertussis_Homo sapiens_hsa051330.79788745
58Inositol phosphate metabolism_Homo sapiens_hsa005620.78738523
59Pancreatic cancer_Homo sapiens_hsa052120.78684135
60African trypanosomiasis_Homo sapiens_hsa051430.75699155
61Lysine degradation_Homo sapiens_hsa003100.75266621
62Small cell lung cancer_Homo sapiens_hsa052220.75083852
63AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74327801
64Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.74060937
65Primary immunodeficiency_Homo sapiens_hsa053400.73106509
66Hepatitis C_Homo sapiens_hsa051600.72657882
67Chemokine signaling pathway_Homo sapiens_hsa040620.72593166
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71548579
69Phagosome_Homo sapiens_hsa041450.71052160
70ECM-receptor interaction_Homo sapiens_hsa045120.67790455
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67720840
72Systemic lupus erythematosus_Homo sapiens_hsa053220.64700943
73Leukocyte transendothelial migration_Homo sapiens_hsa046700.64435923
74Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.63394497
75mTOR signaling pathway_Homo sapiens_hsa041500.63208858
76Prolactin signaling pathway_Homo sapiens_hsa049170.62970174
77Nitrogen metabolism_Homo sapiens_hsa009100.62906171
78Choline metabolism in cancer_Homo sapiens_hsa052310.61838674
79Prostate cancer_Homo sapiens_hsa052150.61412766
80Amoebiasis_Homo sapiens_hsa051460.61144001
81Insulin resistance_Homo sapiens_hsa049310.58434285
82Focal adhesion_Homo sapiens_hsa045100.58375101
83Chronic myeloid leukemia_Homo sapiens_hsa052200.58280795
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55671339
85Other glycan degradation_Homo sapiens_hsa005110.53808908
86MicroRNAs in cancer_Homo sapiens_hsa052060.53663518
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.53561082
88Apoptosis_Homo sapiens_hsa042100.53139572
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.52624198
90Chemical carcinogenesis_Homo sapiens_hsa052040.50872034
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49634967
92Renal cell carcinoma_Homo sapiens_hsa052110.49570633
93TGF-beta signaling pathway_Homo sapiens_hsa043500.47031000
94Histidine metabolism_Homo sapiens_hsa003400.46853027
95Peroxisome_Homo sapiens_hsa041460.46248516
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.46198794
97Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45631226
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45614629
99Linoleic acid metabolism_Homo sapiens_hsa005910.45175438
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44373197

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