NOTCH1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron projection extension involved in neuron projection guidance (GO:1902284)6.88107081
2axon extension involved in axon guidance (GO:0048846)6.88107081
3lung epithelium development (GO:0060428)6.30494884
4lens fiber cell development (GO:0070307)5.62185883
5radial glial cell differentiation (GO:0060019)4.95209847
6negative regulation of erythrocyte differentiation (GO:0045647)4.64385749
7* epithelial cell fate commitment (GO:0072148)4.36511488
8negative regulation of cell killing (GO:0031342)4.31314196
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.31314196
10positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)4.28373869
11positive regulation by symbiont of host defense response (GO:0052509)4.11842093
12modulation by symbiont of host defense response (GO:0052031)4.11842093
13modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.11842093
14modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.11842093
15positive regulation by organism of defense response of other organism involved in symbiotic interact4.11842093
16modulation by symbiont of host immune response (GO:0052553)4.11842093
17axon ensheathment in central nervous system (GO:0032291)4.01775596
18central nervous system myelination (GO:0022010)4.01775596
19positive thymic T cell selection (GO:0045059)4.00982852
20antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.97969884
21lateral sprouting from an epithelium (GO:0060601)3.94631097
22renal system development (GO:0072001)3.90764727
23regulation of gamma-delta T cell differentiation (GO:0045586)3.83594531
24detection of other organism (GO:0098543)3.80928980
25astrocyte differentiation (GO:0048708)3.77588651
26regulation of gamma-delta T cell activation (GO:0046643)3.75199916
27positive regulation of gamma-delta T cell activation (GO:0046645)3.72678577
28chondrocyte proliferation (GO:0035988)3.68085548
29leukocyte aggregation (GO:0070486)3.66850061
30planar cell polarity pathway involved in neural tube closure (GO:0090179)3.66385248
31negative regulation of astrocyte differentiation (GO:0048712)3.64167920
32detection of bacterium (GO:0016045)3.64068817
33auditory receptor cell differentiation (GO:0042491)3.63333541
34regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.61942781
35inner ear receptor cell differentiation (GO:0060113)3.60222305
36mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.57284430
37somite development (GO:0061053)3.55381029
38positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.54537959
39positive T cell selection (GO:0043368)3.50449152
40negative T cell selection (GO:0043383)3.44896357
41antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.44388538
42antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.44388538
43* Notch signaling involved in heart development (GO:0061314)3.42869645
44* response to muramyl dipeptide (GO:0032495)3.42623972
45macrophage activation involved in immune response (GO:0002281)3.42182081
46embryonic camera-type eye development (GO:0031076)3.39429850
47regulation of B cell receptor signaling pathway (GO:0050855)3.36706065
48thymic T cell selection (GO:0045061)3.34634609
49negative thymic T cell selection (GO:0045060)3.28496754
50embryonic foregut morphogenesis (GO:0048617)3.27737801
51* epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.24363277
52midgut development (GO:0007494)3.20420399
53germinal center formation (GO:0002467)3.20345032
54* neuronal stem cell maintenance (GO:0097150)3.20158207
55detection of external biotic stimulus (GO:0098581)3.19304545
56response to peptidoglycan (GO:0032494)3.17802666
57response to interleukin-15 (GO:0070672)3.13036148
58negative regulation of chondrocyte differentiation (GO:0032331)3.10549031
59cellular extravasation (GO:0045123)3.08625987
60exocrine pancreas development (GO:0031017)3.05644811
61positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.01477817
62detection of molecule of bacterial origin (GO:0032490)3.00181845
63Peyers patch development (GO:0048541)2.98200631
64mucosal-associated lymphoid tissue development (GO:0048537)2.98200631
65type B pancreatic cell development (GO:0003323)2.97707564
66digestive tract morphogenesis (GO:0048546)2.97542353
67negative regulation of epidermis development (GO:0045683)2.97005038
68T cell selection (GO:0045058)2.95914304
69negative regulation of interleukin-12 production (GO:0032695)2.95374418
70positive regulation of neuroblast proliferation (GO:0002052)2.94404707
71negative regulation of axon guidance (GO:1902668)2.92423179
72response to laminar fluid shear stress (GO:0034616)2.91203731
73negative regulation of lymphocyte mediated immunity (GO:0002707)2.89664518
74detection of biotic stimulus (GO:0009595)2.89637702
75histone H3-K36 demethylation (GO:0070544)2.89394584
76lens morphogenesis in camera-type eye (GO:0002089)2.86332207
77negative regulation of leukocyte mediated immunity (GO:0002704)2.86060549
78cell proliferation involved in metanephros development (GO:0072203)2.85909202
79positive regulation of histone deacetylation (GO:0031065)2.83816263
80antigen processing and presentation of endogenous antigen (GO:0019883)2.82793289
81B cell receptor signaling pathway (GO:0050853)2.82458485
82lung lobe morphogenesis (GO:0060463)2.82088322
83regulation of leukocyte degranulation (GO:0043300)2.81558167
84neutrophil activation involved in immune response (GO:0002283)2.81020168
85positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.79180921
86negative regulation of smoothened signaling pathway (GO:0045879)2.78769821
87* endocardial cushion morphogenesis (GO:0003203)2.78532189
88hair cell differentiation (GO:0035315)2.78504078
89establishment of planar polarity (GO:0001736)2.77113479
90establishment of tissue polarity (GO:0007164)2.77113479
91atrial septum morphogenesis (GO:0060413)2.76664111
92negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.75828203
93thalamus development (GO:0021794)2.75492509
94embryonic viscerocranium morphogenesis (GO:0048703)2.75070089
95protein localization to endosome (GO:0036010)2.74124144
96dorsal/ventral neural tube patterning (GO:0021904)2.73416047
97negative regulation of T cell mediated immunity (GO:0002710)2.72012823
98positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.71857013
99positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.70575848
100response to host immune response (GO:0052572)2.70552842
101response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.70552842
102regulation of interferon-beta biosynthetic process (GO:0045357)2.70371354
103mannose metabolic process (GO:0006013)2.69916602
104cellular response to interleukin-15 (GO:0071350)2.69615447
105establishment of nucleus localization (GO:0040023)2.69136014
106regulation of myeloid leukocyte mediated immunity (GO:0002886)2.68789616
107positive regulation of extracellular matrix organization (GO:1903055)2.67898523
108mammary gland epithelial cell differentiation (GO:0060644)2.67188625
109T cell migration (GO:0072678)2.66462660
110positive regulation of B cell differentiation (GO:0045579)2.66131029
111tolerance induction (GO:0002507)2.65964026
112positive regulation of Notch signaling pathway (GO:0045747)2.65617341
113glandular epithelial cell development (GO:0002068)2.65416181
114dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.65286769
115negative regulation of toll-like receptor signaling pathway (GO:0034122)2.63809216
116DNA unwinding involved in DNA replication (GO:0006268)2.62855459
117peptidyl-tyrosine autophosphorylation (GO:0038083)2.62370685
118* regulation of extracellular matrix organization (GO:1903053)2.61879428
119signal complex assembly (GO:0007172)2.61685892
120osteoblast development (GO:0002076)2.61541638
121natural killer cell differentiation (GO:0001779)2.60093200
122* cell surface receptor signaling pathway involved in heart development (GO:0061311)2.60050112
123response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.59768036
124response to host (GO:0075136)2.59768036
125response to host defenses (GO:0052200)2.59768036
126* positive regulation of BMP signaling pathway (GO:0030513)2.59122906
127regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)2.58966320
128* positive regulation of epithelial to mesenchymal transition (GO:0010718)2.58362020
129regulation of T cell tolerance induction (GO:0002664)2.57465386
130macrophage activation (GO:0042116)2.57143058
131regulation of extracellular matrix disassembly (GO:0010715)2.55907754
132negative regulation of cartilage development (GO:0061037)2.55882203
133NIK/NF-kappaB signaling (GO:0038061)2.54771225
134* heart valve formation (GO:0003188)2.53611241
135regulation of mast cell degranulation (GO:0043304)2.53440817
136regulation of ARF GTPase activity (GO:0032312)2.52269617
137regulation of B cell differentiation (GO:0045577)2.51784582
138bone morphogenesis (GO:0060349)2.51594743
139forebrain morphogenesis (GO:0048853)2.51065743
140V(D)J recombination (GO:0033151)2.50667980
141positive regulation of granulocyte differentiation (GO:0030854)2.49872253
142negative regulation of granulocyte differentiation (GO:0030853)2.49468047
1433-UTR-mediated mRNA stabilization (GO:0070935)2.49130853
144* negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.48801055
145regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.48734434
146positive regulation of neural precursor cell proliferation (GO:2000179)2.48005409
147negative regulation of axon extension involved in axon guidance (GO:0048843)2.47555104
148regulation of transforming growth factor beta2 production (GO:0032909)2.47373853
149* Notch receptor processing (GO:0007220)2.46704444
150paraxial mesoderm development (GO:0048339)2.46255145
151regulation of granulocyte differentiation (GO:0030852)2.45620029
152neuron fate determination (GO:0048664)2.45069401
153myoblast migration (GO:0051451)2.45006624
154neutrophil activation (GO:0042119)2.45005327
155leukocyte migration involved in inflammatory response (GO:0002523)2.44240305
156regulation of tolerance induction (GO:0002643)2.44034037
157aorta morphogenesis (GO:0035909)2.44028455
158regulation of dendritic cell antigen processing and presentation (GO:0002604)2.43786537
159antigen processing and presentation via MHC class Ib (GO:0002475)2.41623974
160* apoptotic process involved in morphogenesis (GO:0060561)2.41444425
161anatomical structure regression (GO:0060033)2.40712277
162glomerular filtration (GO:0003094)2.40318249
163positive regulation of receptor recycling (GO:0001921)2.39043829
164regulation of heart morphogenesis (GO:2000826)2.38867811
165cellular response to cholesterol (GO:0071397)2.38427342
166respiratory tube development (GO:0030323)2.37771361
167negative regulation of phagocytosis (GO:0050765)2.36966312
168negative regulation of osteoblast proliferation (GO:0033689)2.36860133
169* epithelial cell differentiation involved in prostate gland development (GO:0060742)2.36286022
170mechanoreceptor differentiation (GO:0042490)2.36032503
171histone lysine demethylation (GO:0070076)2.35986205
172* regulation of astrocyte differentiation (GO:0048710)2.35400135
173* trabecula morphogenesis (GO:0061383)2.35320090
174negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.35044627
175response to type I interferon (GO:0034340)2.34800275
176lipopolysaccharide-mediated signaling pathway (GO:0031663)2.34425144
177regulation of NFAT protein import into nucleus (GO:0051532)2.34192623
178hemidesmosome assembly (GO:0031581)2.33620076
179type I interferon signaling pathway (GO:0060337)2.32707293
180cellular response to type I interferon (GO:0071357)2.32707293
181JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.29684670
182positive regulation of Rap GTPase activity (GO:0032854)2.29340243
183modulation by symbiont of host cellular process (GO:0044068)2.28958977
184granulocyte activation (GO:0036230)2.28925455

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* TP63_17297297_ChIP-ChIP_HaCaT_Human5.45606115
2E2F7_22180533_ChIP-Seq_HELA_Human5.16912063
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.46041761
4FOXM1_23109430_ChIP-Seq_U2OS_Human4.30316312
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.13049979
6MYC_22102868_ChIP-Seq_BL_Human3.83604434
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.68345207
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.17995140
9* VDR_21846776_ChIP-Seq_THP-1_Human2.65511285
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.63770915
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.60941144
12VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.57760145
13* TCF7_22412390_ChIP-Seq_EML_Mouse2.50407724
14KDM2B_26808549_Chip-Seq_DND41_Human2.42191729
15* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.41060042
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.23669649
17KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.22620395
18* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.20136642
19* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.17226054
20* ELK3_25401928_ChIP-Seq_HUVEC_Human2.17187289
21SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.13042217
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.06854088
23MAF_26560356_Chip-Seq_TH1_Human2.05670810
24RUNX_20019798_ChIP-Seq_JUKART_Human2.01153641
25TRIM28_21343339_ChIP-Seq_HEK293_Human1.97745476
26* KDM2B_26808549_Chip-Seq_JURKAT_Human1.88069726
27* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.81511983
28UTX_26944678_Chip-Seq_JUKART_Human1.77452182
29IRF8_27001747_Chip-Seq_BMDM_Mouse1.72410947
30STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.68337479
31ZFP281_27345836_Chip-Seq_ESCs_Mouse1.64902269
32* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.63558941
33ZFP281_18757296_ChIP-ChIP_E14_Mouse1.58327436
34BP1_19119308_ChIP-ChIP_Hs578T_Human1.57523077
35RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.56779071
36* LXR_22292898_ChIP-Seq_THP-1_Human1.55854014
37CLOCK_20551151_ChIP-Seq_293T_Human1.53726420
38* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.53482266
39MYB_26560356_Chip-Seq_TH2_Human1.52360347
40* VDR_24763502_ChIP-Seq_THP-1_Human1.52241490
41ESR2_21235772_ChIP-Seq_MCF-7_Human1.51501396
42IRF8_21731497_ChIP-ChIP_J774_Mouse1.50124261
43TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49267405
44GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.48538180
45FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.47998459
46SCL_19346495_ChIP-Seq_HPC-7_Human1.47745360
47FOXO3_23340844_ChIP-Seq_DLD1_Human1.45245345
48EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45143628
49KDM2B_26808549_Chip-Seq_K562_Human1.43023833
50* RACK7_27058665_Chip-Seq_MCF-7_Human1.42916077
51DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.42497617
52* GATA1_19941827_ChIP-Seq_MEL_Mouse1.41862742
53SOX9_24532713_ChIP-Seq_HFSC_Mouse1.41582135
54HIF1A_21447827_ChIP-Seq_MCF-7_Human1.38983371
55FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.37726602
56* TP63_19390658_ChIP-ChIP_HaCaT_Human1.30006854
57SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.28785422
58* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.27446269
59CIITA_25753668_ChIP-Seq_RAJI_Human1.26846787
60SPI1_23547873_ChIP-Seq_NB4_Human1.26383040
61MAF_26560356_Chip-Seq_TH2_Human1.26139662
62* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.25576005
63* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.24983561
64MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.24807151
65RARG_19884340_ChIP-ChIP_MEFs_Mouse1.24794264
66CTCF_27219007_Chip-Seq_ERYTHROID_Human1.23003571
67ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.22672439
68ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.22504780
69P300_27058665_Chip-Seq_ZR-75-30cells_Human1.22276276
70BRD4_27068464_Chip-Seq_AML-cells_Mouse1.21989460
71ESR1_21235772_ChIP-Seq_MCF-7_Human1.21829852
72MYB_26560356_Chip-Seq_TH1_Human1.21277612
73STAT4_19710469_ChIP-ChIP_TH1__Mouse1.20591100
74SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17185930
75IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.16819699
76TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14620095
77SA1_27219007_Chip-Seq_ERYTHROID_Human1.14536101
78CDX2_20551321_ChIP-Seq_CACO-2_Human1.13293917
79ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.12898088
80* SPI1_23127762_ChIP-Seq_K562_Human1.12616593
81NFIB_24661679_ChIP-Seq_LUNG_Mouse1.12088866
82ZNF263_19887448_ChIP-Seq_K562_Human1.11816990
83KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11221112
84E2F4_17652178_ChIP-ChIP_JURKAT_Human1.11017298
85NOTCH1_21737748_ChIP-Seq_TLL_Human1.10321465
86TP53_20018659_ChIP-ChIP_R1E_Mouse1.09299923
87VDR_24787735_ChIP-Seq_THP-1_Human1.08742112
88UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.08544585
89GATA2_21666600_ChIP-Seq_HMVEC_Human1.08437238
90GATA1_19941826_ChIP-Seq_K562_Human1.08268205
91* SMC4_20622854_ChIP-Seq_HELA_Human1.08193965
92RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.07130989
93CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.05975766
94GATA1_22383799_ChIP-Seq_G1ME_Mouse1.04960365
95* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.04460280
96* RUNX1_27514584_Chip-Seq_MCF-7_Human1.03182851
97* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.02329372
98* UBF1/2_26484160_Chip-Seq_HMECs_Human1.02111270
99DROSHA_22980978_ChIP-Seq_HELA_Human1.01863430
100MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.00874126
101* P68_20966046_ChIP-Seq_HELA_Human0.99741116
102FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.98706064
103THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.98001618
104PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97724984
105ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.97620986
106* GATA3_27048872_Chip-Seq_THYMUS_Human0.97480356
107RUNX1_22412390_ChIP-Seq_EML_Mouse0.97303532
108Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.96792188
109ERG_21242973_ChIP-ChIP_JURKAT_Human0.96564227
110CREB1_26743006_Chip-Seq_LNCaP_Human0.95342548
111GATA2_22383799_ChIP-Seq_G1ME_Mouse0.94409143
112* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94021706
113TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.93659784
114* TBX20_22328084_ChIP-Seq_HEART_Mouse0.93207043
115* TBX20_22080862_ChIP-Seq_HEART_Mouse0.93207043
116* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93132079
117PU_27001747_Chip-Seq_BMDM_Mouse0.92975139
118TCF3_18692474_ChIP-Seq_MEFs_Mouse0.92549994
119TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.91812035
120ISL1_27105846_Chip-Seq_CPCs_Mouse0.91509585
121NCOR1_26117541_ChIP-Seq_K562_Human0.91050020
122* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90941529
123CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.90529563
124NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.90264857
125ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.89759397
126AR_21909140_ChIP-Seq_LNCAP_Human0.89546082
127SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.88933755
128POU5F1_16518401_ChIP-PET_MESCs_Mouse0.87539429
129NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.87296790
130* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.86216176
131TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.86102597
132PPAR_26484153_Chip-Seq_NCI-H1993_Human0.86059386
133ATF3_27146783_Chip-Seq_COLON_Human0.85691497
134FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.84382937
135CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.82783669

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis6.86341836
2MP0010030_abnormal_orbit_morphology4.40228118
3MP0009780_abnormal_chondrocyte_physiolo3.58700445
4MP0003724_increased_susceptibility_to3.19334807
5MP0000383_abnormal_hair_follicle2.62373275
6MP0009278_abnormal_bone_marrow2.41257809
7MP0008961_abnormal_basal_metabolism2.23792353
8MP0005076_abnormal_cell_differentiation2.20455527
9MP0008260_abnormal_autophagy2.20259810
10MP0002419_abnormal_innate_immunity2.17069581
11MP0003763_abnormal_thymus_physiology2.16132720
12MP0003300_gastrointestinal_ulcer2.15060007
13MP0002249_abnormal_larynx_morphology2.10144968
14MP0000685_abnormal_immune_system2.03879035
15MP0001835_abnormal_antigen_presentation2.03073760
16MP0010678_abnormal_skin_adnexa2.01069286
17MP0005409_darkened_coat_color2.00732085
18MP0005000_abnormal_immune_tolerance1.99169045
19* MP0001800_abnormal_humoral_immune1.98825727
20* MP0005025_abnormal_response_to1.92027051
21MP0003705_abnormal_hypodermis_morpholog1.87337670
22* MP0002420_abnormal_adaptive_immunity1.85648013
23MP0002089_abnormal_postnatal_growth/wei1.85466183
24* MP0001819_abnormal_immune_cell1.83482214
25MP0000428_abnormal_craniofacial_morphol1.82704147
26* MP0004381_abnormal_hair_follicle1.81199551
27MP0002452_abnormal_antigen_presenting1.74935383
28* MP0002723_abnormal_immune_serum1.74373114
29MP0000465_gastrointestinal_hemorrhage1.71039690
30MP0003191_abnormal_cellular_cholesterol1.70367531
31MP0003172_abnormal_lysosome_physiology1.68236093
32MP0000537_abnormal_urethra_morphology1.66453921
33MP0005451_abnormal_body_composition1.64548861
34MP0003453_abnormal_keratinocyte_physiol1.60700596
35MP0001958_emphysema1.59397869
36MP0000467_abnormal_esophagus_morphology1.57073837
37MP0004858_abnormal_nervous_system1.53737099
38MP0001533_abnormal_skeleton_physiology1.53725334
39MP0000049_abnormal_middle_ear1.53366191
40MP0000579_abnormal_nail_morphology1.51952790
41MP0009053_abnormal_anal_canal1.50205674
42MP0002282_abnormal_trachea_morphology1.49731535
43MP0002098_abnormal_vibrissa_morphology1.49000022
44MP0010352_gastrointestinal_tract_polyps1.48987435
45* MP0000716_abnormal_immune_system1.48645897
46MP0002396_abnormal_hematopoietic_system1.48586987
47MP0003115_abnormal_respiratory_system1.48229269
48MP0004808_abnormal_hematopoietic_stem1.47343360
49MP0002009_preneoplasia1.45135222
50MP0000858_altered_metastatic_potential1.43101933
51MP0010368_abnormal_lymphatic_system1.38613097
52MP0003303_peritoneal_inflammation1.37323615
53MP0002092_abnormal_eye_morphology1.37011906
54MP0004510_myositis1.36985231
55MP0002877_abnormal_melanocyte_morpholog1.34736161
56MP0002998_abnormal_bone_remodeling1.32392692
57MP0001851_eye_inflammation1.31353945
58MP0005423_abnormal_somatic_nervous1.30366972
59MP0005058_abnormal_lysosome_morphology1.29805630
60MP0001293_anophthalmia1.29397813
61MP0009785_altered_susceptibility_to1.28708526
62MP0005257_abnormal_intraocular_pressure1.28375825
63* MP0002722_abnormal_immune_system1.27616954
64MP0001873_stomach_inflammation1.25573955
65MP0002234_abnormal_pharynx_morphology1.23191279
66MP0002148_abnormal_hypersensitivity_rea1.22990111
67* MP0000703_abnormal_thymus_morphology1.22726447
68MP0005464_abnormal_platelet_physiology1.22226239
69MP0003941_abnormal_skin_development1.21531657
70MP0009333_abnormal_splenocyte_physiolog1.18606881
71MP0002166_altered_tumor_susceptibility1.18358511
72MP0004947_skin_inflammation1.18131994
73MP0003566_abnormal_cell_adhesion1.17558553
74* MP0002429_abnormal_blood_cell1.17474285
75MP0005671_abnormal_response_to1.17125508
76MP0006082_CNS_inflammation1.15056556
77MP0003690_abnormal_glial_cell1.14681562
78MP0001849_ear_inflammation1.14121287
79MP0005023_abnormal_wound_healing1.13891969
80* MP0000377_abnormal_hair_follicle1.12960448
81MP0000762_abnormal_tongue_morphology1.09660297
82MP0003828_pulmonary_edema1.07990953
83MP0000689_abnormal_spleen_morphology1.07393421
84MP0000733_abnormal_muscle_development1.07160263
85MP0002796_impaired_skin_barrier1.06323975
86MP0005167_abnormal_blood-brain_barrier1.02428907
87MP0004134_abnormal_chest_morphology1.00696367
88MP0002653_abnormal_ependyma_morphology1.00580595
89MP0003935_abnormal_craniofacial_develop1.00284298
90MP0010155_abnormal_intestine_physiology0.99697141
91MP0003938_abnormal_ear_development0.99219249
92MP0002933_joint_inflammation0.99096610
93MP0003436_decreased_susceptibility_to0.98893677
94MP0004272_abnormal_basement_membrane0.98798304
95MP0002751_abnormal_autonomic_nervous0.97227811
96MP0010234_abnormal_vibrissa_follicle0.95821231
97MP0005508_abnormal_skeleton_morphology0.95722419
98MP0001845_abnormal_inflammatory_respons0.95056635
99MP0000569_abnormal_digit_pigmentation0.93987498
100MP0006054_spinal_hemorrhage0.93983529
101MP0005397_hematopoietic_system_phenotyp0.92793407
102MP0001545_abnormal_hematopoietic_system0.92793407
103MP0004264_abnormal_extraembryonic_tissu0.92367845
104MP0003075_altered_response_to0.91317872
105MP0000767_abnormal_smooth_muscle0.90457196
106MP0002932_abnormal_joint_morphology0.90297754
107MP0005310_abnormal_salivary_gland0.89717203
108* MP0002925_abnormal_cardiovascular_devel0.88633329
109MP0003045_fibrosis0.88012694
110MP0005666_abnormal_adipose_tissue0.88000744
111MP0003283_abnormal_digestive_organ0.87979835
112MP0003755_abnormal_palate_morphology0.87918508
113MP0008007_abnormal_cellular_replicative0.87868670
114MP0002405_respiratory_system_inflammati0.87398881
115MP0000249_abnormal_blood_vessel0.87046163
116MP0002254_reproductive_system_inflammat0.86596601
117MP0005248_abnormal_Harderian_gland0.86006863
118MP0001879_abnormal_lymphatic_vessel0.85892455
119MP0000350_abnormal_cell_proliferation0.85589269
120MP0002006_tumorigenesis0.85258162
121MP0003279_aneurysm0.85181578
122* MP0001216_abnormal_epidermal_layer0.84739585
123MP0003091_abnormal_cell_migration0.84359689
124* MP0000647_abnormal_sebaceous_gland0.84178741
125MP0002233_abnormal_nose_morphology0.82474399
126MP0004185_abnormal_adipocyte_glucose0.82197960
127MP0002102_abnormal_ear_morphology0.81732815
128MP0002116_abnormal_craniofacial_bone0.81540045
129MP0002060_abnormal_skin_morphology0.81373080
130MP0001286_abnormal_eye_development0.80725466
131MP0003329_amyloid_beta_deposits0.80311226
132MP0005390_skeleton_phenotype0.80147395
133* MP0002398_abnormal_bone_marrow0.79807878
134* MP0009931_abnormal_skin_appearance0.79722724
135MP0004883_abnormal_blood_vessel0.78540943
136MP0001299_abnormal_eye_distance/0.77925126
137MP0001915_intracranial_hemorrhage0.77919879
138* MP0002084_abnormal_developmental_patter0.77841737
139* MP0002088_abnormal_embryonic_growth/wei0.77805931
140* MP0003984_embryonic_growth_retardation0.77004514
141MP0002111_abnormal_tail_morphology0.76910444
142MP0003183_abnormal_peptide_metabolism0.76753032
143MP0004197_abnormal_fetal_growth/weight/0.76646821
144MP0002138_abnormal_hepatobiliary_system0.76413977
145MP0000432_abnormal_head_morphology0.75451275
146* MP0002085_abnormal_embryonic_tissue0.75197163
147MP0003111_abnormal_nucleus_morphology0.75015213
148MP0003866_abnormal_defecation0.74293109
149MP0001790_abnormal_immune_system0.74226212
150MP0005387_immune_system_phenotype0.74226212
151MP0000490_abnormal_crypts_of0.74013375
152MP0003448_altered_tumor_morphology0.74005320
153MP0006138_congestive_heart_failure0.72253420
154MP0005388_respiratory_system_phenotype0.72181874
155MP0002133_abnormal_respiratory_system0.72181874

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.92271155
2Neonatal short-limb short stature (HP:0008921)4.42493858
3Partial duplication of thumb phalanx (HP:0009944)3.96528584
4Increased IgE level (HP:0003212)3.90750098
5Coronal craniosynostosis (HP:0004440)3.74925020
6Aplasia involving bones of the upper limbs (HP:0009823)3.60931365
7Aplasia of the phalanges of the hand (HP:0009802)3.60931365
8Aplasia involving bones of the extremities (HP:0009825)3.60931365
9Alacrima (HP:0000522)3.60493471
10Partial duplication of the phalanx of hand (HP:0009999)3.50151849
11Broad face (HP:0000283)3.44476807
12Spontaneous hematomas (HP:0007420)3.38982668
13Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.28625473
14Short 4th metacarpal (HP:0010044)3.28625473
15Recurrent bacterial skin infections (HP:0005406)3.14871126
16Recurrent abscess formation (HP:0002722)3.11660830
17Heterotopia (HP:0002282)3.03818489
18Obstructive sleep apnea (HP:0002870)3.02227021
19Myositis (HP:0100614)2.97311191
20Cellulitis (HP:0100658)2.90493269
21Broad hallux (HP:0010055)2.86281461
22Decreased lacrimation (HP:0000633)2.85395403
23Orchitis (HP:0100796)2.81196284
24Abnormality of macrophages (HP:0004311)2.79427200
25Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.77288878
26Recurrent fungal infections (HP:0002841)2.74327817
27Abnormality of the salivary glands (HP:0010286)2.67639222
28Gingivitis (HP:0000230)2.62540308
29Germ cell neoplasia (HP:0100728)2.61881811
30Neonatal death (HP:0003811)2.61182312
31Megalencephaly (HP:0001355)2.59635558
32Abnormality of the antihelix (HP:0009738)2.59226524
33Aortic aneurysm (HP:0004942)2.58953936
34Abnormality of the lumbar spine (HP:0100712)2.49768420
35Increased nuchal translucency (HP:0010880)2.48875208
36Retrobulbar optic neuritis (HP:0100654)2.48520047
37Optic neuritis (HP:0100653)2.48520047
38Abnormality of the middle phalanges of the toes (HP:0010183)2.48473607
39Uterine leiomyosarcoma (HP:0002891)2.48394130
40Leiomyosarcoma (HP:0100243)2.48394130
41Broad toe (HP:0001837)2.47958427
42Thickened helices (HP:0000391)2.44917884
43Thick nail (HP:0001805)2.44562790
44Abnormality of the 4th metacarpal (HP:0010012)2.44038880
45Meningitis (HP:0001287)2.43964910
46Hallux valgus (HP:0001822)2.42657720
47Recurrent corneal erosions (HP:0000495)2.42536472
48Xerostomia (HP:0000217)2.42371080
49Duplication of thumb phalanx (HP:0009942)2.40034147
50Trigonocephaly (HP:0000243)2.39093078
51Recurrent gram-negative bacterial infections (HP:0005420)2.37776331
52Arterial tortuosity (HP:0005116)2.36793220
53Mediastinal lymphadenopathy (HP:0100721)2.33712892
54Deviation of the hallux (HP:0010051)2.33459689
55Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.31741058
56Limited elbow extension (HP:0001377)2.31587666
57Esophageal atresia (HP:0002032)2.30117623
58Abnormal number of incisors (HP:0011064)2.27968036
59Spondylolisthesis (HP:0003302)2.27631652
60Abnormality of the fingertips (HP:0001211)2.24930682
61Plagiocephaly (HP:0001357)2.24166024
62Milia (HP:0001056)2.23287115
63Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.22863297
64Chronic obstructive pulmonary disease (HP:0006510)2.22649980
65Obstructive lung disease (HP:0006536)2.22649980
66Gastrointestinal inflammation (HP:0004386)2.20638979
67Ankyloglossia (HP:0010296)2.20354862
68Visceral angiomatosis (HP:0100761)2.20063348
69Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.19658900
70Polygenic inheritance (HP:0010982)2.19051335
71Mixed hearing impairment (HP:0000410)2.18468603
72Subacute progressive viral hepatitis (HP:0006572)2.18032229
73Colitis (HP:0002583)2.17599434
74Camptodactyly of toe (HP:0001836)2.17414812
75Atrophic scars (HP:0001075)2.17232025
76Cerebral aneurysm (HP:0004944)2.16964302
77Nasolacrimal duct obstruction (HP:0000579)2.16909141
78Infantile muscular hypotonia (HP:0008947)2.15045113
79Keratoconjunctivitis sicca (HP:0001097)2.14291431
80Transitional cell carcinoma of the bladder (HP:0006740)2.11000860
81Vascular tortuosity (HP:0004948)2.09552556
82Bifid scrotum (HP:0000048)2.09360426
83Abnormality of oral frenula (HP:0000190)2.08673114
84Elevated erythrocyte sedimentation rate (HP:0003565)2.08525549
85Inflammation of the large intestine (HP:0002037)2.08419105
86Abnormal delayed hypersensitivity skin test (HP:0002963)2.08320563
87Gastrointestinal infarctions (HP:0005244)2.07395038
88Recurrent viral infections (HP:0004429)2.07061573
89Hemangiomatosis (HP:0007461)2.04550294
90Abnormality of incisor morphology (HP:0011063)2.04070486
91Abnormality of nail color (HP:0100643)2.04064172
92Abnormality of the incisor (HP:0000676)2.03394481
93Panhypogammaglobulinemia (HP:0003139)2.03143552
94Protrusio acetabuli (HP:0003179)2.02871226
95Malignant gastrointestinal tract tumors (HP:0006749)2.02796285
96Gastrointestinal carcinoma (HP:0002672)2.02796285
97Aplasia/Hypoplasia of the scapulae (HP:0006713)2.02088843
98Hypoplastic scapulae (HP:0000882)2.02088843
99Segmental peripheral demyelination/remyelination (HP:0003481)1.99946806
100Preaxial foot polydactyly (HP:0001841)1.99797049
101Recurrent skin infections (HP:0001581)1.99747566
102Down-sloping shoulders (HP:0200021)1.97502222
103Pseudobulbar signs (HP:0002200)1.97366894
104Prolonged bleeding time (HP:0003010)1.96990858
105Arnold-Chiari malformation (HP:0002308)1.96875884
106Shallow orbits (HP:0000586)1.96819884
107Chest pain (HP:0100749)1.95025799
108Proximal placement of thumb (HP:0009623)1.92663640
109Hemorrhage of the eye (HP:0011885)1.92345552
110Broad alveolar ridges (HP:0000187)1.92266329
111Sepsis (HP:0100806)1.92028861
112Viral hepatitis (HP:0006562)1.91714119
113Interstitial pulmonary disease (HP:0006530)1.91491942
114Low anterior hairline (HP:0000294)1.90817112
115Premature skin wrinkling (HP:0100678)1.89637578
116Pustule (HP:0200039)1.88735821
117Recurrent cutaneous fungal infections (HP:0011370)1.88337148
118Chronic mucocutaneous candidiasis (HP:0002728)1.88337148
119Vasculitis (HP:0002633)1.87378795
120Hyperacusis (HP:0010780)1.87034532
121Abnormal vertebral ossification (HP:0100569)1.86769030
122Abnormality of the costochondral junction (HP:0000919)1.86611926
123Bladder neoplasm (HP:0009725)1.86355796
124Bladder carcinoma (HP:0002862)1.86355796
125Abnormally folded helix (HP:0008544)1.85934120
126Abnormality of the intervertebral disk (HP:0005108)1.85067926
127Aortic dissection (HP:0002647)1.83984843
128Joint contractures involving the joints of the feet (HP:0100492)1.82765672
129Flexion contracture of toe (HP:0005830)1.82765672
130Synostosis of carpal bones (HP:0005048)1.82668079
131Abnormality of the distal phalanx of the thumb (HP:0009617)1.82241780
132T lymphocytopenia (HP:0005403)1.82081134
133Deviation of the thumb (HP:0009603)1.81220285
134Urticaria (HP:0001025)1.81045946
135Metaphyseal cupping (HP:0003021)1.80034187
136Keratoconjunctivitis (HP:0001096)1.79869354
137Disproportionate tall stature (HP:0001519)1.79178685
138Granulocytopenia (HP:0001913)1.78596463
139Abnormality of the lacrimal duct (HP:0011481)1.78341707
140Skin tags (HP:0010609)1.78232038
141Aneurysm (HP:0002617)1.78113499
142Overfolded helix (HP:0000396)1.76708677
143Increased density of long bones (HP:0006392)1.76682162
144Encephalitis (HP:0002383)1.75233295
145Neurofibrillary tangles (HP:0002185)1.74735827
146Hemoptysis (HP:0002105)1.74014438
147Ureteral stenosis (HP:0000071)1.73903334
148Dilatation of the ascending aorta (HP:0005111)1.73839213
149Increased variability in muscle fiber diameter (HP:0003557)1.73724827
150Conical tooth (HP:0000698)1.73558656
151Lymphopenia (HP:0001888)1.73284998
152Slow saccadic eye movements (HP:0000514)1.73072963
153Increased connective tissue (HP:0009025)1.72429837
154Skin ulcer (HP:0200042)1.71872588
155Tarsal synostosis (HP:0008368)1.71712116
156Selective tooth agenesis (HP:0001592)1.71347586
157Stomatitis (HP:0010280)1.70644701
158Mitral valve prolapse (HP:0001634)1.70443255
159Spinal canal stenosis (HP:0003416)1.69670247
160Onion bulb formation (HP:0003383)1.69626694
161Abnormality of T cell number (HP:0011839)1.69290025
162Verrucae (HP:0200043)1.69101610
163Papilloma (HP:0012740)1.69101610
164Abnormality of the musculature of the hand (HP:0001421)1.69009039
165Abnormality of the columella (HP:0009929)1.68978251
166Long eyelashes (HP:0000527)1.68575910
167Peritonitis (HP:0002586)1.68201123
168Vertebral arch anomaly (HP:0008438)1.67480896
169Large earlobe (HP:0009748)1.67101727
170Epistaxis (HP:0000421)1.67046795
171Supernumerary nipples (HP:0002558)1.66928385
172Woolly hair (HP:0002224)1.66882677
173Osteomyelitis (HP:0002754)1.66599803
174Hematochezia (HP:0002573)1.65457406
175Premature loss of primary teeth (HP:0006323)1.65215574
176Dislocated radial head (HP:0003083)1.64917751
177Abnormality of cells of the lymphoid lineage (HP:0012140)1.63730810
178Difficulty running (HP:0009046)1.63398197
179Absent forearm bone (HP:0003953)1.63200017
180Aplasia involving forearm bones (HP:0009822)1.63200017
181Mitral regurgitation (HP:0001653)1.62879533
182Supernumerary ribs (HP:0005815)1.62633698
183Amyloidosis (HP:0011034)1.60456577
184Autoimmune thrombocytopenia (HP:0001973)1.59901347
185Leukocytosis (HP:0001974)1.59748296
186Arterial thrombosis (HP:0004420)1.59569013
187Pointed chin (HP:0000307)1.59441236
188Thin bony cortex (HP:0002753)1.58633916
189Persistence of primary teeth (HP:0006335)1.58270240

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR34.36236824
2MAP3K103.71999947
3BUB13.56072123
4EEF2K3.34146337
5PRPF4B3.28879444
6TRIB32.89971390
7EPHB22.86807912
8SMG12.77091433
9FGFR42.62710070
10CDK122.49542134
11FES2.47065989
12FGFR22.26701372
13RIPK42.18231511
14SIK12.18003060
15FGFR12.08627830
16MAP4K12.08475818
17PKN21.97417840
18PASK1.90015299
19ERN11.89960966
20BLK1.85062491
21IRAK41.84901563
22MARK21.72687150
23MAP2K31.70040928
24EPHB11.67302140
25MAP3K71.64879981
26MELK1.62449474
27PDGFRA1.61450487
28TYRO31.56182569
29STK101.56120806
30PTK61.54112634
31CDK81.51151561
32BRD41.49216481
33MAP3K131.47682342
34TXK1.45238211
35SIK31.40618060
36TNK21.37185034
37ICK1.36731463
38CDK91.33979922
39TGFBR21.33445075
40TTN1.24796876
41PAK41.22657386
42JAK31.20923118
43RIPK11.20224840
44CDK41.19528509
45ITK1.19480333
46TAOK11.19247974
47EPHA31.16375518
48KSR21.14515792
49NEK21.14416090
50DMPK1.13686505
51FGR1.11787932
52CHUK1.10626435
53MAP3K31.09545688
54LRRK21.06852072
55CDC42BPA1.05913488
56CSK1.04904927
57MTOR1.02730651
58TGFBR11.02488556
59GRK61.02260536
60MAP3K10.99943214
61KDR0.99616883
62TIE10.99199938
63PRKD20.98243525
64NLK0.95906599
65NTRK20.94913037
66KSR10.92865669
67RPS6KB20.92508562
68PDGFRB0.90220587
69IRAK10.89638048
70MAP3K60.88076104
71CAMK1D0.83692930
72IRAK20.83666575
73MAP3K110.83005302
74SYK0.82379867
75RPS6KC10.81872490
76RPS6KL10.81872490
77RPS6KA20.81063229
78TYK20.80934348
79CLK10.80772178
80MAPK70.79776427
81BTK0.79229678
82CDK60.79194821
83ROCK20.78157064
84ERBB20.77582960
85HIPK20.76826013
86ZAP700.74494942
87YES10.73572420
88LYN0.72408365
89MAPK120.70760311
90CAMK1G0.70645764
91HCK0.68452235
92IRAK30.68287728
93SGK30.67439454
94CDC70.64693403
95RPS6KA40.63501632
96RPS6KA60.61996843
97SIK20.61442983
98DDR20.60494010
99TLK10.59381514
100JAK10.59263439
101FYN0.57920488
102NTRK10.55170377
103BMX0.54000027
104LCK0.53528346
105UHMK10.52684753
106WNK10.50350912
107MAP3K20.48701279
108MOS0.48655926
109CAMKK10.48211409
110CSF1R0.46845398
111PDPK10.45946047
112PAK20.43930312
113ATR0.43001816
114KIT0.41086429
115SGK20.40150402
116JAK20.40129331
117DYRK1B0.40074908
118MAP3K80.40061974
119RPS6KA10.39849574
120MAPK110.39178913
121ALK0.39049255
122IKBKE0.39035450
123ROCK10.37940557
124TBK10.37634427
125MAPKAPK20.37533350
126MAP3K140.36797660
127AKT20.36466161
128STK40.36460489
129MAPK90.36214322
130AURKB0.36086115
131ILK0.35588951
132TSSK60.35358673
133PRKCH0.35206874
134CDK70.34635437
135CHEK10.32713029
136PIM10.32166274
137DYRK30.31980906
138RET0.30102679
139IGF1R0.30002266
140LATS10.29475151

Predicted pathways (KEGG)

RankGene SetZ-score
1* Notch signaling pathway_Homo sapiens_hsa043303.94246876
2Basal cell carcinoma_Homo sapiens_hsa052173.10286722
3Hedgehog signaling pathway_Homo sapiens_hsa043402.01683228
4Chronic myeloid leukemia_Homo sapiens_hsa052201.98676945
5* MicroRNAs in cancer_Homo sapiens_hsa052061.88274014
6T cell receptor signaling pathway_Homo sapiens_hsa046601.84249636
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.82417652
8Primary immunodeficiency_Homo sapiens_hsa053401.80735955
9Viral myocarditis_Homo sapiens_hsa054161.78862001
10HTLV-I infection_Homo sapiens_hsa051661.73213882
11Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.71616413
12Bladder cancer_Homo sapiens_hsa052191.69556689
13Adherens junction_Homo sapiens_hsa045201.69486312
14Small cell lung cancer_Homo sapiens_hsa052221.67215615
15Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.65999067
16Lysine degradation_Homo sapiens_hsa003101.59839256
17AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.58294084
18Proteoglycans in cancer_Homo sapiens_hsa052051.54903599
19Hippo signaling pathway_Homo sapiens_hsa043901.50540394
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.50424656
21Measles_Homo sapiens_hsa051621.47096611
22Pancreatic cancer_Homo sapiens_hsa052121.41790928
23Colorectal cancer_Homo sapiens_hsa052101.38300002
24Leukocyte transendothelial migration_Homo sapiens_hsa046701.38295767
25Leishmaniasis_Homo sapiens_hsa051401.35270247
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.34483479
27Acute myeloid leukemia_Homo sapiens_hsa052211.33746113
28Toxoplasmosis_Homo sapiens_hsa051451.31656699
29Other glycan degradation_Homo sapiens_hsa005111.28743094
30Hepatitis B_Homo sapiens_hsa051611.25871819
31Pathways in cancer_Homo sapiens_hsa052001.25173049
32Base excision repair_Homo sapiens_hsa034101.25064658
33Tuberculosis_Homo sapiens_hsa051521.24882451
34Central carbon metabolism in cancer_Homo sapiens_hsa052301.23735225
35Transcriptional misregulation in cancer_Homo sapiens_hsa052021.21536465
36Focal adhesion_Homo sapiens_hsa045101.19673297
37Osteoclast differentiation_Homo sapiens_hsa043801.19133103
38Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.18439242
39Spliceosome_Homo sapiens_hsa030401.17842529
40mRNA surveillance pathway_Homo sapiens_hsa030151.17397632
41Jak-STAT signaling pathway_Homo sapiens_hsa046301.16768907
42Phospholipase D signaling pathway_Homo sapiens_hsa040721.16269072
43Cell cycle_Homo sapiens_hsa041101.15902958
44* Dorso-ventral axis formation_Homo sapiens_hsa043201.12720365
45Wnt signaling pathway_Homo sapiens_hsa043101.11214335
46* Thyroid hormone signaling pathway_Homo sapiens_hsa049191.11122668
47ErbB signaling pathway_Homo sapiens_hsa040121.10986130
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.09045692
49Non-small cell lung cancer_Homo sapiens_hsa052231.08045137
50TGF-beta signaling pathway_Homo sapiens_hsa043501.07653928
51Viral carcinogenesis_Homo sapiens_hsa052031.05215024
52B cell receptor signaling pathway_Homo sapiens_hsa046621.04135758
53DNA replication_Homo sapiens_hsa030301.01449243
54Herpes simplex infection_Homo sapiens_hsa051681.01163657
55Endometrial cancer_Homo sapiens_hsa052130.98908320
56Choline metabolism in cancer_Homo sapiens_hsa052310.98245267
57Axon guidance_Homo sapiens_hsa043600.96095192
58ECM-receptor interaction_Homo sapiens_hsa045120.94673146
59Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.94649803
60GnRH signaling pathway_Homo sapiens_hsa049120.94439251
61Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93823755
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.93464431
63Apoptosis_Homo sapiens_hsa042100.92693843
64Graft-versus-host disease_Homo sapiens_hsa053320.92642341
65TNF signaling pathway_Homo sapiens_hsa046680.92396317
66Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.92226347
67Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.91917330
68Prostate cancer_Homo sapiens_hsa052150.89619711
69Antigen processing and presentation_Homo sapiens_hsa046120.89377371
70Intestinal immune network for IgA production_Homo sapiens_hsa046720.87833956
71Insulin resistance_Homo sapiens_hsa049310.86790675
72Hematopoietic cell lineage_Homo sapiens_hsa046400.85805346
73VEGF signaling pathway_Homo sapiens_hsa043700.85101602
74mTOR signaling pathway_Homo sapiens_hsa041500.85035634
75Renal cell carcinoma_Homo sapiens_hsa052110.84926891
76Inositol phosphate metabolism_Homo sapiens_hsa005620.84561314
77Toll-like receptor signaling pathway_Homo sapiens_hsa046200.83550609
78Rap1 signaling pathway_Homo sapiens_hsa040150.83476526
79Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.82020376
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.81968790
81Regulation of actin cytoskeleton_Homo sapiens_hsa048100.81381072
82Prolactin signaling pathway_Homo sapiens_hsa049170.81301234
83Salmonella infection_Homo sapiens_hsa051320.81103145
84Autoimmune thyroid disease_Homo sapiens_hsa053200.80368272
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.79981070
86Influenza A_Homo sapiens_hsa051640.79015907
87Estrogen signaling pathway_Homo sapiens_hsa049150.78483145
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77946190
89Non-homologous end-joining_Homo sapiens_hsa034500.77649222
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.76362580
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74720833
92Malaria_Homo sapiens_hsa051440.71779023
93Endocytosis_Homo sapiens_hsa041440.71683835
94Thyroid cancer_Homo sapiens_hsa052160.71481029
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71318519
96PI3K-Akt signaling pathway_Homo sapiens_hsa041510.70255702
97Staphylococcus aureus infection_Homo sapiens_hsa051500.70136317
98Melanogenesis_Homo sapiens_hsa049160.69621584
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69498823
100Insulin signaling pathway_Homo sapiens_hsa049100.68492767
101Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68409531
102Chemokine signaling pathway_Homo sapiens_hsa040620.68182652
103p53 signaling pathway_Homo sapiens_hsa041150.67619998
104Platelet activation_Homo sapiens_hsa046110.67307351
105Amoebiasis_Homo sapiens_hsa051460.66557849
106HIF-1 signaling pathway_Homo sapiens_hsa040660.66550308
107Glioma_Homo sapiens_hsa052140.64498043
108Legionellosis_Homo sapiens_hsa051340.64486977
109MAPK signaling pathway_Homo sapiens_hsa040100.64364637
110Shigellosis_Homo sapiens_hsa051310.62530965
111Phagosome_Homo sapiens_hsa041450.59996848
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.59745619
113Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58941515
114FoxO signaling pathway_Homo sapiens_hsa040680.58440100
115Ras signaling pathway_Homo sapiens_hsa040140.58000790
116RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.57033033
117Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56698135
118Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.55386356
119Epstein-Barr virus infection_Homo sapiens_hsa051690.54533742
120Allograft rejection_Homo sapiens_hsa053300.54348571
121Pertussis_Homo sapiens_hsa051330.51865918
122Hepatitis C_Homo sapiens_hsa051600.47907056
123NOD-like receptor signaling pathway_Homo sapiens_hsa046210.46446991
124AMPK signaling pathway_Homo sapiens_hsa041520.44899041

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