NOS2P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.23980762
2fucose catabolic process (GO:0019317)4.72368206
3L-fucose metabolic process (GO:0042354)4.72368206
4L-fucose catabolic process (GO:0042355)4.72368206
5piRNA metabolic process (GO:0034587)4.34749995
6indole-containing compound catabolic process (GO:0042436)4.26962131
7indolalkylamine catabolic process (GO:0046218)4.26962131
8tryptophan catabolic process (GO:0006569)4.26962131
9protein-cofactor linkage (GO:0018065)4.17833214
10DNA deamination (GO:0045006)4.11766805
11detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.97834723
12kynurenine metabolic process (GO:0070189)3.81435468
13indolalkylamine metabolic process (GO:0006586)3.69871268
14cellular ketone body metabolic process (GO:0046950)3.67634631
15tryptophan metabolic process (GO:0006568)3.60637351
16epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.56719259
17water-soluble vitamin biosynthetic process (GO:0042364)3.50996251
18platelet dense granule organization (GO:0060155)3.50409321
19response to pheromone (GO:0019236)3.47802368
20DNA methylation involved in gamete generation (GO:0043046)3.39427907
21negative regulation of synaptic transmission, GABAergic (GO:0032229)3.35242288
22ketone body metabolic process (GO:1902224)3.31296712
23protein polyglutamylation (GO:0018095)3.29948978
24somatic diversification of immune receptors via somatic mutation (GO:0002566)3.29897782
25somatic hypermutation of immunoglobulin genes (GO:0016446)3.29897782
26negative regulation of mast cell activation (GO:0033004)3.28536417
27protein neddylation (GO:0045116)3.25076920
28gamma-aminobutyric acid transport (GO:0015812)3.17949218
29negative regulation of telomere maintenance (GO:0032205)3.13275607
30regulation of action potential (GO:0098900)3.08046990
31epithelial cilium movement (GO:0003351)3.08005506
32regulation of nuclear cell cycle DNA replication (GO:0033262)3.07084703
33regulation of cilium movement (GO:0003352)3.06082566
34behavioral response to ethanol (GO:0048149)3.05074471
35protein localization to cilium (GO:0061512)3.03722652
36preassembly of GPI anchor in ER membrane (GO:0016254)3.03042016
37detection of light stimulus involved in visual perception (GO:0050908)2.99532823
38detection of light stimulus involved in sensory perception (GO:0050962)2.99532823
39male meiosis (GO:0007140)2.99431534
40synapsis (GO:0007129)2.98295966
41axoneme assembly (GO:0035082)2.98148524
42cilium morphogenesis (GO:0060271)2.96093867
43regulation of rhodopsin mediated signaling pathway (GO:0022400)2.95618178
44photoreceptor cell maintenance (GO:0045494)2.91052686
45protein K11-linked deubiquitination (GO:0035871)2.88890376
46amine catabolic process (GO:0009310)2.87064334
47cellular biogenic amine catabolic process (GO:0042402)2.87064334
48reflex (GO:0060004)2.86796180
49rhodopsin mediated signaling pathway (GO:0016056)2.84704478
50nonmotile primary cilium assembly (GO:0035058)2.84303933
51photoreceptor cell development (GO:0042461)2.83426486
52indole-containing compound metabolic process (GO:0042430)2.82621504
53negative regulation of cytosolic calcium ion concentration (GO:0051481)2.82128770
54mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.80395873
55mitochondrial respiratory chain complex I assembly (GO:0032981)2.80395873
56NADH dehydrogenase complex assembly (GO:0010257)2.80395873
57cilium or flagellum-dependent cell motility (GO:0001539)2.80346700
58sulfation (GO:0051923)2.78797830
59adaptation of signaling pathway (GO:0023058)2.77974868
60pyrimidine nucleobase catabolic process (GO:0006208)2.71550935
61tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.71481419
62RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.71481419
63retinal cone cell development (GO:0046549)2.71138841
64protein complex biogenesis (GO:0070271)2.67793162
65regulation of meiosis I (GO:0060631)2.67014405
66multicellular organism reproduction (GO:0032504)2.65335931
67sperm motility (GO:0030317)2.61406061
68ubiquinone biosynthetic process (GO:0006744)2.60116735
69negative regulation of fibroblast apoptotic process (GO:2000270)2.59169889
70cellular response to ATP (GO:0071318)2.57853035
71synaptic transmission, cholinergic (GO:0007271)2.57372919
72neuronal action potential (GO:0019228)2.57233841
73neurotransmitter-gated ion channel clustering (GO:0072578)2.56443848
74L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.55536732
75mitochondrial respiratory chain complex assembly (GO:0033108)2.53568607
76inner ear receptor stereocilium organization (GO:0060122)2.52781119
77respiratory chain complex IV assembly (GO:0008535)2.52542402
78auditory receptor cell stereocilium organization (GO:0060088)2.52515435
79cytidine deamination (GO:0009972)2.51144908
80cytidine metabolic process (GO:0046087)2.51144908
81cytidine catabolic process (GO:0006216)2.51144908
82regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.50926301
83cilium organization (GO:0044782)2.50278685
84cilium movement (GO:0003341)2.49936959
85nucleobase catabolic process (GO:0046113)2.49579592
86aromatic amino acid family catabolic process (GO:0009074)2.49536722
87kidney morphogenesis (GO:0060993)2.47985259
88cilium assembly (GO:0042384)2.47823534
89recombinational repair (GO:0000725)2.47502508
90tongue development (GO:0043586)2.47411591
91GPI anchor metabolic process (GO:0006505)2.46363704
92cAMP catabolic process (GO:0006198)2.46126663
93regulation of fibroblast apoptotic process (GO:2000269)2.44737712
94regulation of neurotransmitter uptake (GO:0051580)2.44590241
95eye photoreceptor cell development (GO:0042462)2.43949466
96detection of mechanical stimulus involved in sensory perception (GO:0050974)2.43897005
97double-strand break repair via homologous recombination (GO:0000724)2.43887774
98ubiquinone metabolic process (GO:0006743)2.43575038
99regulation of telomere maintenance (GO:0032204)2.42060162
100regulation of memory T cell differentiation (GO:0043380)2.42016826

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.86217700
2VDR_22108803_ChIP-Seq_LS180_Human3.48859359
3EZH2_22144423_ChIP-Seq_EOC_Human3.31219808
4GBX2_23144817_ChIP-Seq_PC3_Human2.96166803
5IGF1R_20145208_ChIP-Seq_DFB_Human2.87556182
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.72039682
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.62034687
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.56470806
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.37516933
10TAF15_26573619_Chip-Seq_HEK293_Human2.25497503
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.23966663
12CTBP1_25329375_ChIP-Seq_LNCAP_Human2.18426106
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.15137866
14FUS_26573619_Chip-Seq_HEK293_Human2.10989048
15P300_19829295_ChIP-Seq_ESCs_Human2.08150570
16ER_23166858_ChIP-Seq_MCF-7_Human2.04855147
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.01158753
18SALL1_21062744_ChIP-ChIP_HESCs_Human1.95405231
19EWS_26573619_Chip-Seq_HEK293_Human1.91839373
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.90906095
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.90394079
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.89335607
23BCAT_22108803_ChIP-Seq_LS180_Human1.72103390
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.70390934
25CBP_20019798_ChIP-Seq_JUKART_Human1.68667805
26IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.68667805
27IRF1_19129219_ChIP-ChIP_H3396_Human1.65674593
28NOTCH1_21737748_ChIP-Seq_TLL_Human1.62889163
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.62762885
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.53925585
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.53517665
32UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.52535576
33STAT3_23295773_ChIP-Seq_U87_Human1.51195692
34TP53_22573176_ChIP-Seq_HFKS_Human1.50484733
35NR3C1_21868756_ChIP-Seq_MCF10A_Human1.47876382
36AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.47649308
37MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.47310315
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46798321
39POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.46352924
40TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46352924
41SMAD4_21799915_ChIP-Seq_A2780_Human1.44504313
42CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.44137522
43FOXA1_25329375_ChIP-Seq_VCAP_Human1.43696224
44FOXA1_27270436_Chip-Seq_PROSTATE_Human1.43696224
45AR_25329375_ChIP-Seq_VCAP_Human1.43622375
46MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.42054728
47KLF5_20875108_ChIP-Seq_MESCs_Mouse1.38019318
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37842766
49TCF4_23295773_ChIP-Seq_U87_Human1.35969630
50REST_21632747_ChIP-Seq_MESCs_Mouse1.34480931
51NANOG_19829295_ChIP-Seq_ESCs_Human1.34007063
52SOX2_19829295_ChIP-Seq_ESCs_Human1.34007063
53KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.30800131
54RUNX2_22187159_ChIP-Seq_PCA_Human1.30629453
55NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.30065108
56TCF4_22108803_ChIP-Seq_LS180_Human1.29399415
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29319531
58GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.29113702
59GABP_17652178_ChIP-ChIP_JURKAT_Human1.27298628
60AR_21572438_ChIP-Seq_LNCaP_Human1.26759846
61BMI1_23680149_ChIP-Seq_NPCS_Mouse1.26554307
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24800396
63FOXA1_21572438_ChIP-Seq_LNCaP_Human1.24079804
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.23877927
65ETV2_25802403_ChIP-Seq_MESCs_Mouse1.22150179
66EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.21641096
67NCOR_22424771_ChIP-Seq_293T_Human1.21269435
68MYC_18940864_ChIP-ChIP_HL60_Human1.20847562
69SMAD4_21741376_ChIP-Seq_EPCs_Human1.20610601
70PRDM14_20953172_ChIP-Seq_ESCs_Human1.19949425
71SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19168134
72EZH2_27294783_Chip-Seq_NPCs_Mouse1.19035864
73PCGF2_27294783_Chip-Seq_NPCs_Mouse1.17899891
74NFE2_27457419_Chip-Seq_LIVER_Mouse1.16981050
75CBX2_27304074_Chip-Seq_ESCs_Mouse1.15372465
76GATA3_21878914_ChIP-Seq_MCF-7_Human1.14076288
77SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12505239
78AR_20517297_ChIP-Seq_VCAP_Human1.11630761
79HOXB7_26014856_ChIP-Seq_BT474_Human1.09913430
80FLI1_21867929_ChIP-Seq_TH2_Mouse1.07157265
81MYC_19829295_ChIP-Seq_ESCs_Human1.06163400
82HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.05574938
83TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05232341
84NANOG_18555785_Chip-Seq_ESCs_Mouse1.04860801
85TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04375489
86CDX2_22108803_ChIP-Seq_LS180_Human1.03986107
87CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01755243
88CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.01707157
89P53_22387025_ChIP-Seq_ESCs_Mouse1.01278198
90REST_18959480_ChIP-ChIP_MESCs_Mouse1.00228506
91OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99919103
92EST1_17652178_ChIP-ChIP_JURKAT_Human0.99482111
93CRX_20693478_ChIP-Seq_RETINA_Mouse0.98672322
94NANOG_20526341_ChIP-Seq_ESCs_Human0.98209255
95EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98145231
96ERA_21632823_ChIP-Seq_H3396_Human0.93360340
97TBL1_22424771_ChIP-Seq_293T_Human0.93148151
98TAL1_26923725_Chip-Seq_HPCs_Mouse0.90124804
99RNF2_27304074_Chip-Seq_NSC_Mouse0.89780573
100AUTS2_25519132_ChIP-Seq_293T-REX_Human0.89647861

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.01025234
2MP0003195_calcinosis2.92813645
3MP0002102_abnormal_ear_morphology2.75104267
4MP0001986_abnormal_taste_sensitivity2.72421100
5MP0001968_abnormal_touch/_nociception2.62441179
6MP0002837_dystrophic_cardiac_calcinosis2.53724699
7MP0005551_abnormal_eye_electrophysiolog2.49758561
8MP0006292_abnormal_olfactory_placode2.25145249
9MP0002736_abnormal_nociception_after2.21041608
10MP0009745_abnormal_behavioral_response2.04963901
11MP0004885_abnormal_endolymph2.04539939
12MP0001501_abnormal_sleep_pattern2.04156482
13MP0003787_abnormal_imprinting2.02207149
14MP0005646_abnormal_pituitary_gland1.99977191
15MP0006072_abnormal_retinal_apoptosis1.99495460
16MP0009046_muscle_twitch1.98915921
17MP0008875_abnormal_xenobiotic_pharmacok1.97269475
18MP0001485_abnormal_pinna_reflex1.96889878
19MP0008872_abnormal_physiological_respon1.89512158
20MP0005410_abnormal_fertilization1.81419712
21MP0002272_abnormal_nervous_system1.79466087
22MP0001529_abnormal_vocalization1.77945144
23MP0004147_increased_porphyrin_level1.77789427
24MP0004742_abnormal_vestibular_system1.77709435
25MP0005253_abnormal_eye_physiology1.73901699
26MP0002876_abnormal_thyroid_physiology1.67613118
27MP0004142_abnormal_muscle_tone1.59600317
28MP0003011_delayed_dark_adaptation1.58034377
29MP0000631_abnormal_neuroendocrine_gland1.57551051
30MP0002638_abnormal_pupillary_reflex1.57357966
31MP0001486_abnormal_startle_reflex1.52607679
32MP0003136_yellow_coat_color1.50858455
33MP0003646_muscle_fatigue1.49656574
34MP0005645_abnormal_hypothalamus_physiol1.46078128
35MP0004133_heterotaxia1.43477164
36MP0006276_abnormal_autonomic_nervous1.42685434
37MP0003880_abnormal_central_pattern1.42510362
38MP0001984_abnormal_olfaction1.38044018
39MP0002064_seizures1.34600187
40MP0000427_abnormal_hair_cycle1.34163600
41MP0002572_abnormal_emotion/affect_behav1.31965551
42MP0005377_hearing/vestibular/ear_phenot1.31926055
43MP0003878_abnormal_ear_physiology1.31926055
44MP0005389_reproductive_system_phenotype1.31741953
45MP0002160_abnormal_reproductive_system1.28327828
46MP0002557_abnormal_social/conspecific_i1.27445813
47MP0000372_irregular_coat_pigmentation1.27026385
48MP0004043_abnormal_pH_regulation1.26575374
49MP0005084_abnormal_gallbladder_morpholo1.25939843
50MP0000569_abnormal_digit_pigmentation1.23530682
51MP0002735_abnormal_chemical_nociception1.22038908
52MP0001919_abnormal_reproductive_system1.21168080
53MP0004215_abnormal_myocardial_fiber1.19849779
54MP0003718_maternal_effect1.19707353
55MP0003635_abnormal_synaptic_transmissio1.19334274
56MP0003315_abnormal_perineum_morphology1.19070009
57MP0002277_abnormal_respiratory_mucosa1.18292224
58MP0010386_abnormal_urinary_bladder1.16463048
59MP0008995_early_reproductive_senescence1.12809836
60MP0005187_abnormal_penis_morphology1.12425039
61MP0003890_abnormal_embryonic-extraembry1.12285275
62MP0002733_abnormal_thermal_nociception1.11264242
63MP0002822_catalepsy1.10933833
64MP0001970_abnormal_pain_threshold1.10892634
65MP0003698_abnormal_male_reproductive1.10654213
66MP0002067_abnormal_sensory_capabilities1.09943427
67MP0005386_behavior/neurological_phenoty1.09930172
68MP0004924_abnormal_behavior1.09930172
69MP0002938_white_spotting1.09721156
70MP0008058_abnormal_DNA_repair1.09398018
71MP0002928_abnormal_bile_duct1.06982766
72MP0005423_abnormal_somatic_nervous1.06957556
73MP0001905_abnormal_dopamine_level1.04586148
74MP0002063_abnormal_learning/memory/cond1.04255237
75MP0002229_neurodegeneration1.02783714
76MP0001963_abnormal_hearing_physiology1.00697190
77MP0002138_abnormal_hepatobiliary_system1.00088631
78MP0002653_abnormal_ependyma_morphology0.99910803
79MP0005174_abnormal_tail_pigmentation0.99600703
80MP0005195_abnormal_posterior_eye0.99481586
81MP0001929_abnormal_gametogenesis0.98401985
82MP0002234_abnormal_pharynx_morphology0.97986270
83MP0003283_abnormal_digestive_organ0.96732539
84MP0003252_abnormal_bile_duct0.95853776
85MP0002734_abnormal_mechanical_nocicepti0.95604166
86MP0000026_abnormal_inner_ear0.95345044
87MP0008775_abnormal_heart_ventricle0.93625702
88MP0001764_abnormal_homeostasis0.93552879
89MP0003119_abnormal_digestive_system0.92286924
90MP0003137_abnormal_impulse_conducting0.91322136
91MP0002752_abnormal_somatic_nervous0.89830321
92MP0002210_abnormal_sex_determination0.89693348
93MP0002254_reproductive_system_inflammat0.86890613
94MP0003121_genomic_imprinting0.86354597
95MP0002693_abnormal_pancreas_physiology0.85636532
96MP0002751_abnormal_autonomic_nervous0.84933948
97MP0000383_abnormal_hair_follicle0.84917859
98MP0000230_abnormal_systemic_arterial0.83794767
99MP0002909_abnormal_adrenal_gland0.81268511
100MP0008789_abnormal_olfactory_epithelium0.80821840

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.34064486
2Pancreatic fibrosis (HP:0100732)3.85730203
3Molar tooth sign on MRI (HP:0002419)3.76180149
4Abnormality of midbrain morphology (HP:0002418)3.76180149
5True hermaphroditism (HP:0010459)3.72693851
6Type II lissencephaly (HP:0007260)3.41882938
7Congenital stationary night blindness (HP:0007642)3.37984719
8Nephronophthisis (HP:0000090)3.19279028
9Hyperventilation (HP:0002883)3.15910558
10Abnormality of the renal cortex (HP:0011035)3.05709452
11Pendular nystagmus (HP:0012043)3.00929126
12Abolished electroretinogram (ERG) (HP:0000550)2.94742278
13Progressive cerebellar ataxia (HP:0002073)2.88451747
14Abnormality of the renal medulla (HP:0100957)2.80050240
15Attenuation of retinal blood vessels (HP:0007843)2.75695131
16Medial flaring of the eyebrow (HP:0010747)2.75542762
17Inability to walk (HP:0002540)2.75490036
18Retinal dysplasia (HP:0007973)2.73604033
19Cystic liver disease (HP:0006706)2.72738735
20Large for gestational age (HP:0001520)2.61533846
21Gaze-evoked nystagmus (HP:0000640)2.60538990
22Polydipsia (HP:0001959)2.59028727
23Abnormal drinking behavior (HP:0030082)2.59028727
24Chronic hepatic failure (HP:0100626)2.55867287
25Tubular atrophy (HP:0000092)2.55161038
26Genetic anticipation (HP:0003743)2.50210133
27Thyroid-stimulating hormone excess (HP:0002925)2.38221204
28Chorioretinal atrophy (HP:0000533)2.35833828
29Sclerocornea (HP:0000647)2.35535362
30Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.33840024
31Abnormality of alanine metabolism (HP:0010916)2.33840024
32Hyperalaninemia (HP:0003348)2.33840024
33Lissencephaly (HP:0001339)2.32158318
34Aplasia/hypoplasia of the uterus (HP:0008684)2.31601287
35Broad-based gait (HP:0002136)2.30500909
36Hyperglycinemia (HP:0002154)2.25915204
37Hypothermia (HP:0002045)2.24117087
38Abnormal rod and cone electroretinograms (HP:0008323)2.22776315
39Renal cortical cysts (HP:0000803)2.21218298
40Progressive inability to walk (HP:0002505)2.18959044
41Bony spicule pigmentary retinopathy (HP:0007737)2.18011942
42Cerebellar dysplasia (HP:0007033)2.17521810
43Male pseudohermaphroditism (HP:0000037)2.16505730
44Hyperglycinuria (HP:0003108)2.15590032
45Protruding tongue (HP:0010808)2.15204953
46Gait imbalance (HP:0002141)2.15192614
47Absent/shortened dynein arms (HP:0200106)2.14000175
48Dynein arm defect of respiratory motile cilia (HP:0012255)2.14000175
49Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.13335133
50Methylmalonic acidemia (HP:0002912)2.13073558
51Abnormal biliary tract physiology (HP:0012439)2.12882008
52Bile duct proliferation (HP:0001408)2.12882008
53Acute encephalopathy (HP:0006846)2.12383071
54Toxemia of pregnancy (HP:0100603)2.10642719
55Increased corneal curvature (HP:0100692)2.10368969
56Keratoconus (HP:0000563)2.10368969
57Congenital, generalized hypertrichosis (HP:0004540)2.08938149
58Optic nerve hypoplasia (HP:0000609)2.08391073
59Congenital primary aphakia (HP:0007707)2.06714191
60Polyuria (HP:0000103)2.04303608
61Anencephaly (HP:0002323)2.04225886
62Limb hypertonia (HP:0002509)2.03072377
63Acute necrotizing encephalopathy (HP:0006965)2.02456614
64Clumsiness (HP:0002312)2.02258457
65Febrile seizures (HP:0002373)2.01452117
66Pachygyria (HP:0001302)2.00951156
67Aplasia/Hypoplasia of the tongue (HP:0010295)2.00774904
68Absent rod-and cone-mediated responses on ERG (HP:0007688)1.99962224
693-Methylglutaconic aciduria (HP:0003535)1.99588913
70Severe muscular hypotonia (HP:0006829)1.99037975
71Polyphagia (HP:0002591)1.98576391
72Abnormality of the pons (HP:0007361)1.98440828
73Hypoplasia of the uterus (HP:0000013)1.96950459
74Furrowed tongue (HP:0000221)1.96265790
75Abnormal respiratory motile cilium morphology (HP:0005938)1.95149354
76Abnormal respiratory epithelium morphology (HP:0012253)1.95149354
77Mitochondrial inheritance (HP:0001427)1.94227120
78Methylmalonic aciduria (HP:0012120)1.92697942
79Concave nail (HP:0001598)1.92394902
80Disproportionate short-trunk short stature (HP:0003521)1.90616260
81Stomach cancer (HP:0012126)1.90370644
82Nephrogenic diabetes insipidus (HP:0009806)1.89867768
83Abnormality of the labia minora (HP:0012880)1.88945811
84Congenital hepatic fibrosis (HP:0002612)1.88822891
85Decreased central vision (HP:0007663)1.88198819
86Increased CSF lactate (HP:0002490)1.86918251
87Hepatic necrosis (HP:0002605)1.85181801
88Tachypnea (HP:0002789)1.84730399
89Hypoplasia of the pons (HP:0012110)1.84068516
90Ketosis (HP:0001946)1.84008798
91Intestinal atresia (HP:0011100)1.83848340
92Abnormality of serine family amino acid metabolism (HP:0010894)1.83611949
93Abnormality of glycine metabolism (HP:0010895)1.83611949
94Progressive macrocephaly (HP:0004481)1.83118365
95Decreased electroretinogram (ERG) amplitude (HP:0000654)1.81348943
96Retinitis pigmentosa (HP:0000510)1.80650385
97Ketoacidosis (HP:0001993)1.80397814
98Hemiparesis (HP:0001269)1.79473270
99Postaxial foot polydactyly (HP:0001830)1.78305847
100Genital tract atresia (HP:0001827)1.77824525

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.05655213
2ZAK3.60307467
3ADRBK23.30929722
4PINK13.25561459
5GRK12.69883841
6MAP4K22.53108677
7BMPR1B2.28459502
8TAOK32.27969052
9WNK32.26244745
10WNK42.23915518
11NUAK12.20239561
12ACVR1B2.13885380
13CASK2.06856439
14OXSR12.06687642
15TLK11.90656185
16MAP3K41.68097934
17PHKG11.64276964
18PHKG21.64276964
19MAPK131.62308661
20DAPK21.54557553
21STK38L1.52271688
22CDK191.50866718
23TXK1.48992921
24MAP2K71.48813132
25INSRR1.43216587
26MST41.40267117
27DYRK21.39957088
28MARK11.38849100
29STK391.35642877
30PAK31.29012162
31PRKCE1.09990113
32PNCK1.08728517
33TSSK61.03217609
34CSNK1G11.03047426
35CSNK1G31.00157161
36ADRBK11.00086143
37TAF10.97376342
38CSNK1G20.96031380
39MKNK20.95272163
40TEC0.94186083
41TGFBR10.93974765
42TRIM280.93239144
43TIE10.91729216
44BCKDK0.91491617
45PRKCG0.91163542
46FER0.87542462
47CSNK1A1L0.86138143
48FGFR20.84424279
49PLK20.82790753
50ITK0.82776277
51RPS6KA50.79655579
52PKN10.79055602
53TNIK0.71969510
54PIK3CA0.68233912
55PRKCQ0.67797795
56NTRK20.66581154
57BRSK20.64987413
58ERBB30.64845731
59MAPKAPK50.64104968
60PRKAA20.62489394
61MAPK150.61636742
62VRK10.60113357
63CAMKK20.59073776
64MAPKAPK30.57428072
65ERBB20.55410606
66MKNK10.53404603
67EPHB20.53101635
68WEE10.52681446
69NTRK30.52126590
70PRKCI0.52114587
71MARK30.51901915
72EPHA40.50966560
73PLK30.49348275
74NEK10.47451309
75CAMK2A0.47415840
76PLK40.47134243
77IKBKB0.46661699
78TNK20.45220311
79EIF2AK30.44031065
80PTK2B0.43924432
81PRKACA0.43001797
82STK30.41703161
83NME10.40935904
84CSNK1A10.40781155
85MUSK0.40725872
86PRKG10.40462174
87BCR0.39719526
88MAP2K60.36450297
89PRKCZ0.36392894
90FES0.36116782
91PRKAA10.36062507
92PLK10.34881280
93NLK0.33813084
94STK110.33524301
95PRKCA0.32969093
96CSNK1D0.32688539
97EPHA30.31723783
98NEK20.30811925
99CDK30.30793271
100IRAK10.30553645

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.74057056
2Phototransduction_Homo sapiens_hsa047442.72579020
3Butanoate metabolism_Homo sapiens_hsa006502.67612324
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.51977930
5Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.50259292
6Nitrogen metabolism_Homo sapiens_hsa009102.44391739
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.37014565
8Linoleic acid metabolism_Homo sapiens_hsa005912.29038041
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.17469971
10Propanoate metabolism_Homo sapiens_hsa006402.12874103
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.08268169
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.03726144
13Selenocompound metabolism_Homo sapiens_hsa004502.00132668
14Nicotine addiction_Homo sapiens_hsa050331.96954149
15Maturity onset diabetes of the young_Homo sapiens_hsa049501.96405799
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.95960233
17Protein export_Homo sapiens_hsa030601.94714976
18Tryptophan metabolism_Homo sapiens_hsa003801.86837783
19Oxidative phosphorylation_Homo sapiens_hsa001901.85977514
20Caffeine metabolism_Homo sapiens_hsa002321.74386534
21Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.74096048
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.73929548
23RNA polymerase_Homo sapiens_hsa030201.71434049
24Basal transcription factors_Homo sapiens_hsa030221.62955207
25Ether lipid metabolism_Homo sapiens_hsa005651.58515536
26Primary bile acid biosynthesis_Homo sapiens_hsa001201.53435464
27Fanconi anemia pathway_Homo sapiens_hsa034601.41981481
28Homologous recombination_Homo sapiens_hsa034401.41887081
29Parkinsons disease_Homo sapiens_hsa050121.39834836
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.34884157
31Olfactory transduction_Homo sapiens_hsa047401.30720296
32Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.28975865
33Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.21939533
34Morphine addiction_Homo sapiens_hsa050321.20998877
35Taste transduction_Homo sapiens_hsa047421.15521706
36Chemical carcinogenesis_Homo sapiens_hsa052041.13818453
37Retinol metabolism_Homo sapiens_hsa008301.09997165
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.09826905
39Peroxisome_Homo sapiens_hsa041461.09508028
40Dorso-ventral axis formation_Homo sapiens_hsa043201.07063541
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.03024500
42GABAergic synapse_Homo sapiens_hsa047271.01804682
43Steroid biosynthesis_Homo sapiens_hsa001001.01370487
44One carbon pool by folate_Homo sapiens_hsa006700.97454378
45RNA degradation_Homo sapiens_hsa030180.96821470
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.96100510
47Vitamin digestion and absorption_Homo sapiens_hsa049770.94256663
48ABC transporters_Homo sapiens_hsa020100.93590668
49Proteasome_Homo sapiens_hsa030500.92070084
50Collecting duct acid secretion_Homo sapiens_hsa049660.91683581
51beta-Alanine metabolism_Homo sapiens_hsa004100.90155394
52Circadian entrainment_Homo sapiens_hsa047130.89972736
53Huntingtons disease_Homo sapiens_hsa050160.88193078
54Insulin secretion_Homo sapiens_hsa049110.85914224
55Regulation of autophagy_Homo sapiens_hsa041400.85599137
56Glycerolipid metabolism_Homo sapiens_hsa005610.85494150
57Cardiac muscle contraction_Homo sapiens_hsa042600.83092850
58Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.82255467
59Arachidonic acid metabolism_Homo sapiens_hsa005900.80310459
60Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.79729981
61Intestinal immune network for IgA production_Homo sapiens_hsa046720.79187430
62Sulfur metabolism_Homo sapiens_hsa009200.79139688
63Alzheimers disease_Homo sapiens_hsa050100.78036144
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.77884068
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.77438473
66Glutamatergic synapse_Homo sapiens_hsa047240.77019397
67Serotonergic synapse_Homo sapiens_hsa047260.76268929
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75098645
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74450880
70Purine metabolism_Homo sapiens_hsa002300.74343630
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73111097
72Salivary secretion_Homo sapiens_hsa049700.68574289
73Fat digestion and absorption_Homo sapiens_hsa049750.66874467
74Metabolic pathways_Homo sapiens_hsa011000.66867718
75Ovarian steroidogenesis_Homo sapiens_hsa049130.65759331
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61617902
77Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.61441821
78Mineral absorption_Homo sapiens_hsa049780.60651383
79Histidine metabolism_Homo sapiens_hsa003400.59707666
80Calcium signaling pathway_Homo sapiens_hsa040200.55112964
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51325093
82Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.49757662
83Circadian rhythm_Homo sapiens_hsa047100.45714775
84Vitamin B6 metabolism_Homo sapiens_hsa007500.45335789
85Type I diabetes mellitus_Homo sapiens_hsa049400.44869343
86Fatty acid degradation_Homo sapiens_hsa000710.44164884
87Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.43905846
88Cyanoamino acid metabolism_Homo sapiens_hsa004600.43760191
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40681052
90Pyrimidine metabolism_Homo sapiens_hsa002400.39940360
91Long-term depression_Homo sapiens_hsa047300.39452203
92Non-homologous end-joining_Homo sapiens_hsa034500.38046504
93Asthma_Homo sapiens_hsa053100.37550903
94Sulfur relay system_Homo sapiens_hsa041220.37532980
95Dopaminergic synapse_Homo sapiens_hsa047280.36661889
96Hedgehog signaling pathway_Homo sapiens_hsa043400.35573667
97Fatty acid biosynthesis_Homo sapiens_hsa000610.34419691
98Pyruvate metabolism_Homo sapiens_hsa006200.33864746
99Arginine and proline metabolism_Homo sapiens_hsa003300.32092729
100Cocaine addiction_Homo sapiens_hsa050300.31152128

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