NOS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5' UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.08986822
2synaptic vesicle maturation (GO:0016188)5.64550024
3locomotory exploration behavior (GO:0035641)5.56140252
4regulation of glutamate receptor signaling pathway (GO:1900449)5.38900871
5vocalization behavior (GO:0071625)5.38012177
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.36843050
7regulation of skeletal muscle contraction (GO:0014819)5.31146090
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.16873286
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.16640260
10muscle filament sliding (GO:0030049)5.06804193
11actin-myosin filament sliding (GO:0033275)5.06804193
12regulation of synaptic vesicle exocytosis (GO:2000300)4.97545712
13regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.97081204
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.95820253
15behavioral response to nicotine (GO:0035095)4.95006180
16neuronal action potential propagation (GO:0019227)4.80892707
17sarcoplasmic reticulum calcium ion transport (GO:0070296)4.78843284
18synaptic vesicle docking involved in exocytosis (GO:0016081)4.76956033
19neuron cell-cell adhesion (GO:0007158)4.70310488
20synaptic vesicle exocytosis (GO:0016079)4.67822680
21neurotransmitter secretion (GO:0007269)4.49826468
22skeletal muscle contraction (GO:0003009)4.43049070
23regulation of synaptic vesicle transport (GO:1902803)4.43029115
24glutamate secretion (GO:0014047)4.42371640
25synaptic transmission, glutamatergic (GO:0035249)4.39962891
26neuron-neuron synaptic transmission (GO:0007270)4.39134266
27glutamate receptor signaling pathway (GO:0007215)4.35092966
28behavioral response to ethanol (GO:0048149)4.28087354
29exploration behavior (GO:0035640)4.23461169
30positive regulation of synaptic transmission, GABAergic (GO:0032230)4.21190172
31actin-mediated cell contraction (GO:0070252)4.15478114
32gamma-aminobutyric acid transport (GO:0015812)4.07259308
33proline transport (GO:0015824)4.05740269
34membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.97981037
35regulation of neuronal synaptic plasticity (GO:0048168)3.94950749
36regulation of relaxation of muscle (GO:1901077)3.93203092
37glycine transport (GO:0015816)3.92017861
38cellular potassium ion homeostasis (GO:0030007)3.91442896
39long-term memory (GO:0007616)3.89739161
40cell migration in hindbrain (GO:0021535)3.87063386
41regulation of synapse structural plasticity (GO:0051823)3.86254387
42neuromuscular process controlling posture (GO:0050884)3.85875077
43regulation of long-term neuronal synaptic plasticity (GO:0048169)3.83880142
44protein localization to synapse (GO:0035418)3.83473915
45negative regulation of cytosolic calcium ion concentration (GO:0051481)3.80635773
46neurotransmitter-gated ion channel clustering (GO:0072578)3.77913967
47aggressive behavior (GO:0002118)3.72323270
48cerebellar Purkinje cell differentiation (GO:0021702)3.66653921
49neurotransmitter transport (GO:0006836)3.66168676
50positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.65870706
51G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.61058134
52myotube cell development (GO:0014904)3.60099767
53suckling behavior (GO:0001967)3.59751137
54sodium ion export (GO:0071436)3.55848665
55skeletal muscle fiber development (GO:0048741)3.55633299
56regulation of excitatory postsynaptic membrane potential (GO:0060079)3.54983199
57membrane depolarization during action potential (GO:0086010)3.52941095
58detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.51300347
59positive regulation of membrane potential (GO:0045838)3.50305236
60myofibril assembly (GO:0030239)3.48872925
61negative regulation of synaptic transmission, GABAergic (GO:0032229)3.47053129
62synaptic vesicle endocytosis (GO:0048488)3.46329835
63regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.46207997
64regulation of neurotransmitter secretion (GO:0046928)3.45500428
65innervation (GO:0060384)3.43876708
66neuromuscular process controlling balance (GO:0050885)3.42895046
67positive regulation of neurotransmitter transport (GO:0051590)3.42755141
68L-fucose metabolic process (GO:0042354)3.42703635
69L-fucose catabolic process (GO:0042355)3.42703635
70fucose catabolic process (GO:0019317)3.42703635
71response to auditory stimulus (GO:0010996)3.40493729
72positive regulation of synapse maturation (GO:0090129)3.38683480
73gamma-aminobutyric acid signaling pathway (GO:0007214)3.37294057
74layer formation in cerebral cortex (GO:0021819)3.36947037
75regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.36418250
76response to pheromone (GO:0019236)3.35166637
77auditory receptor cell stereocilium organization (GO:0060088)3.33582580
78regulation of postsynaptic membrane potential (GO:0060078)3.33153430
79* regulation of neurotransmitter levels (GO:0001505)3.32755738
80regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.32294079
81activation of protein kinase A activity (GO:0034199)3.31689424
82dendritic spine morphogenesis (GO:0060997)3.28975836
83kynurenine metabolic process (GO:0070189)3.28112959
84cellular ketone body metabolic process (GO:0046950)3.24981406
85cerebellar granule cell differentiation (GO:0021707)3.24367852
86response to inactivity (GO:0014854)3.24223336
87cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.24202570
88epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.24021476
89detection of light stimulus involved in sensory perception (GO:0050962)3.23321835
90detection of light stimulus involved in visual perception (GO:0050908)3.23321835
91synaptic transmission, dopaminergic (GO:0001963)3.21507121
92* regulation of neurotransmitter transport (GO:0051588)3.20409022
93positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.20302167
94transmission of nerve impulse (GO:0019226)3.20239364
95positive regulation of neurotransmitter secretion (GO:0001956)3.18125472
96response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.17578928
97regulation of synaptic plasticity (GO:0048167)3.17105706
98regulation of hexokinase activity (GO:1903299)3.16694962
99regulation of glucokinase activity (GO:0033131)3.16694962
100prepulse inhibition (GO:0060134)3.15930962
101* striated muscle contraction (GO:0006941)3.14576723
102membrane depolarization (GO:0051899)3.14534830
103postsynaptic membrane organization (GO:0001941)3.12916518
104negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.12685444
105regulation of synaptic transmission, glutamatergic (GO:0051966)3.12345477
106regulation of synapse maturation (GO:0090128)3.11093337
107positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.10633875
108neuromuscular synaptic transmission (GO:0007274)3.09286804
109regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.08472200
110muscle fiber development (GO:0048747)3.07994240
111neuron recognition (GO:0008038)3.07335171
112membrane hyperpolarization (GO:0060081)3.06433641
113long term synaptic depression (GO:0060292)3.06297963
114cell communication by electrical coupling (GO:0010644)3.04263966
115regulation of synaptic transmission, GABAergic (GO:0032228)3.03875299
116synaptic transmission (GO:0007268)3.02381486
117auditory behavior (GO:0031223)3.01449473
118behavioral fear response (GO:0001662)3.01069225
119behavioral defense response (GO:0002209)3.01069225
120positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.00069553
121neuromuscular process (GO:0050905)2.99153047
122response to muscle activity (GO:0014850)2.99113003
123neuronal ion channel clustering (GO:0045161)2.97244975
124synaptic transmission, cholinergic (GO:0007271)2.97088104
125G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.96419485
126ubiquinone biosynthetic process (GO:0006744)2.96063393
127neuronal action potential (GO:0019228)2.95230180
128cell differentiation in hindbrain (GO:0021533)2.94783759
129ketone body metabolic process (GO:1902224)2.94216398
130regulation of sarcomere organization (GO:0060297)2.93861632
131regulation of respiratory gaseous exchange (GO:0043576)2.93847369
132vesicle transport along microtubule (GO:0047496)2.92113381
133intraspecies interaction between organisms (GO:0051703)2.92048196
134social behavior (GO:0035176)2.92048196
135cellular response to ammonium ion (GO:0071242)2.89770420
136skeletal muscle adaptation (GO:0043501)2.89559017
137positive regulation of synaptic transmission (GO:0050806)2.89172297
138indole-containing compound catabolic process (GO:0042436)2.88661757
139indolalkylamine catabolic process (GO:0046218)2.88661757
140tryptophan catabolic process (GO:0006569)2.88661757
141indolalkylamine metabolic process (GO:0006586)2.86778749
142regulation of nuclear cell cycle DNA replication (GO:0033262)2.85875815
143reflex (GO:0060004)2.74998865
144somite development (GO:0061053)2.73929700
145axoneme assembly (GO:0035082)2.72302088
146regulation of action potential (GO:0098900)2.66999201
147L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.65990121
148negative regulation of reactive oxygen species metabolic process (GO:2000378)2.65093898
149ubiquinone metabolic process (GO:0006743)2.64348217
150cornea development in camera-type eye (GO:0061303)2.63887944
151primary amino compound metabolic process (GO:1901160)2.62246819
152respiratory chain complex IV assembly (GO:0008535)2.61571347
153actin filament-based movement (GO:0030048)2.61285984
154negative regulation of telomere maintenance (GO:0032205)2.61238238
155positive regulation of meiosis (GO:0045836)2.59319104
156regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.58989149
157regulation of cell communication by electrical coupling (GO:0010649)2.58730580
158piRNA metabolic process (GO:0034587)2.58304243
159inner ear receptor stereocilium organization (GO:0060122)2.58263798
160plasma membrane repair (GO:0001778)2.58147298
161regulation of sequestering of triglyceride (GO:0010889)2.57975821
162* muscle contraction (GO:0006936)2.56704390
163sarcomere organization (GO:0045214)2.56543921
164calcium ion import (GO:0070509)2.55578726
165regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.54748740
166C4-dicarboxylate transport (GO:0015740)2.53300478
167glycerophospholipid catabolic process (GO:0046475)2.53107012
168creatine metabolic process (GO:0006600)2.52554625
169protein polyglutamylation (GO:0018095)2.52018606
170protein K11-linked deubiquitination (GO:0035871)2.51921560
171action potential (GO:0001508)2.51532363
172kidney morphogenesis (GO:0060993)2.50747932
173myotube differentiation (GO:0014902)2.47186975
174cardiac myofibril assembly (GO:0055003)2.46448578
175epithelial cilium movement (GO:0003351)2.43921336
176adenosine metabolic process (GO:0046085)2.42749790
177retinal cone cell development (GO:0046549)2.41617601
178rhodopsin mediated signaling pathway (GO:0016056)2.41611968
179positive regulation of meiotic cell cycle (GO:0051446)2.41183674
180regulation of rhodopsin mediated signaling pathway (GO:0022400)2.40932231
181indole-containing compound metabolic process (GO:0042430)2.38194188
182response to caffeine (GO:0031000)2.37667089
183DNA deamination (GO:0045006)2.37006851
184positive regulation of fatty acid oxidation (GO:0046321)2.36900913
185quinone biosynthetic process (GO:1901663)2.35968269
186alanine transport (GO:0032328)2.35673995
187tryptophan metabolic process (GO:0006568)2.35608125
188regulation of hippo signaling (GO:0035330)2.35263571
189* muscle system process (GO:0003012)2.34715107

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.83057917
2GBX2_23144817_ChIP-Seq_PC3_Human3.69275110
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.05921302
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.04726814
5VDR_22108803_ChIP-Seq_LS180_Human2.99909786
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.94595803
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.86826893
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.86826893
9* REST_21632747_ChIP-Seq_MESCs_Mouse2.84923886
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.70845521
11* DROSHA_22980978_ChIP-Seq_HELA_Human2.69958190
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.58820383
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.55480132
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.50501461
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.42535892
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.42285749
17* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.38674213
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.32039137
19* RARB_27405468_Chip-Seq_BRAIN_Mouse2.31104236
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.30265683
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.27738169
22EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.26443956
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.26408220
24* REST_18959480_ChIP-ChIP_MESCs_Mouse2.23568293
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.14856510
26IKZF1_21737484_ChIP-ChIP_HCT116_Human2.09666659
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.92416487
28PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.92080563
29RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.91632324
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.89707917
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.79151914
32ERG_21242973_ChIP-ChIP_JURKAT_Human1.76819425
33FUS_26573619_Chip-Seq_HEK293_Human1.74511378
34ER_23166858_ChIP-Seq_MCF-7_Human1.73271209
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.65577252
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.64379199
37EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.62056878
38NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.61872102
39AR_21572438_ChIP-Seq_LNCaP_Human1.60259477
40* SMAD4_21799915_ChIP-Seq_A2780_Human1.57758613
41CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.57423797
42CBP_20019798_ChIP-Seq_JUKART_Human1.54300501
43IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.54300501
44ZNF274_21170338_ChIP-Seq_K562_Hela1.53486122
45EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.50760397
46UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.50015133
47* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.48188327
48SALL1_21062744_ChIP-ChIP_HESCs_Human1.46314972
49* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.45437732
50TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45125617
51POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.45125617
52* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.43500099
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.43299423
54GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42460804
55RING1B_27294783_Chip-Seq_ESCs_Mouse1.41529158
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41132653
57EWS_26573619_Chip-Seq_HEK293_Human1.39449645
58BMI1_23680149_ChIP-Seq_NPCS_Mouse1.36011407
59SOX2_19829295_ChIP-Seq_ESCs_Human1.34425404
60NANOG_19829295_ChIP-Seq_ESCs_Human1.34425404
61BCAT_22108803_ChIP-Seq_LS180_Human1.33537501
62ZFP57_27257070_Chip-Seq_ESCs_Mouse1.33322447
63SUZ12_27294783_Chip-Seq_NPCs_Mouse1.32900961
64SOX2_21211035_ChIP-Seq_LN229_Gbm1.31677485
65CBX2_27304074_Chip-Seq_ESCs_Mouse1.31568521
66NR3C1_23031785_ChIP-Seq_PC12_Mouse1.31314373
67KLF5_20875108_ChIP-Seq_MESCs_Mouse1.30697899
68* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27420494
69MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27379562
70PCGF2_27294783_Chip-Seq_NPCs_Mouse1.27242630
71STAT3_23295773_ChIP-Seq_U87_Human1.27043576
72* RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.27007715
73RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.26378651
74EZH2_27294783_Chip-Seq_NPCs_Mouse1.25874279
75* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25714998
76TP53_22573176_ChIP-Seq_HFKS_Human1.24720966
77AR_25329375_ChIP-Seq_VCAP_Human1.23912772
78AR_19668381_ChIP-Seq_PC3_Human1.22510652
79* P300_19829295_ChIP-Seq_ESCs_Human1.19725672
80TAF15_26573619_Chip-Seq_HEK293_Human1.19281335
81RING1B_27294783_Chip-Seq_NPCs_Mouse1.19060875
82GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.18125407
83* TCF4_22108803_ChIP-Seq_LS180_Human1.17283829
84* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.16126571
85TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15222107
86MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14054349
87* SMAD3_21741376_ChIP-Seq_EPCs_Human1.13165487
88CRX_20693478_ChIP-Seq_RETINA_Mouse1.12584543
89NFE2_27457419_Chip-Seq_LIVER_Mouse1.12362887
90WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12008010
91IGF1R_20145208_ChIP-Seq_DFB_Human1.10952452
92SMAD_19615063_ChIP-ChIP_OVARY_Human1.10803399
93FLI1_21867929_ChIP-Seq_TH2_Mouse1.10456632
94CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09857166
95TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.09375167
96KDM2B_26808549_Chip-Seq_K562_Human1.08667308
97ZFP281_18757296_ChIP-ChIP_E14_Mouse1.08538848
98RNF2_27304074_Chip-Seq_NSC_Mouse1.08353841
99TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04813748
100HOXB7_26014856_ChIP-Seq_BT474_Human1.04667182
101TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04641210
102TCF4_23295773_ChIP-Seq_U87_Human1.04454186
103MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.02391333
104* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02093116
105BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.02044618
106P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01237823
107MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01021369
108* PIAS1_25552417_ChIP-Seq_VCAP_Human1.00970113
109SMAD3_21741376_ChIP-Seq_HESCs_Human1.00893277
110SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.00743646
111CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00183939
112NCOR_22424771_ChIP-Seq_293T_Human1.00066390
113FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.99506521
114GATA3_21878914_ChIP-Seq_MCF-7_Human0.99358619
115CDX2_19796622_ChIP-Seq_MESCs_Mouse0.98906223
116* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.98624018
117OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98480846
118TP53_20018659_ChIP-ChIP_R1E_Mouse0.98425240
119* SMAD4_21741376_ChIP-Seq_HESCs_Human0.98164910
120SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.97505189
121ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97184660
122* SMAD3_21741376_ChIP-Seq_ESCs_Human0.97148940
123OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96735284
124FOXA1_27270436_Chip-Seq_PROSTATE_Human0.96486717
125FOXA1_25329375_ChIP-Seq_VCAP_Human0.96486717
126AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96021876
127OCT4_20526341_ChIP-Seq_ESCs_Human0.95959557
128TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.95510986
129NANOG_18555785_Chip-Seq_ESCs_Mouse0.95431597
130RXR_22108803_ChIP-Seq_LS180_Human0.95249465
131P53_22387025_ChIP-Seq_ESCs_Mouse0.95174990
132* CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.94682651
133TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.92954405
134TP53_16413492_ChIP-PET_HCT116_Human0.92502795
135AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92104654
136NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91982135
137RUNX2_22187159_ChIP-Seq_PCA_Human0.91628470
138* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90713492
139ARNT_22903824_ChIP-Seq_MCF-7_Human0.89754405
140SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89073256
141TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88632933
142TET1_21490601_ChIP-Seq_MESCs_Mouse0.88303214
143POU3F2_20337985_ChIP-ChIP_501MEL_Human0.86570816
144AHR_22903824_ChIP-Seq_MCF-7_Human0.86095056
145* CTCF_27219007_Chip-Seq_Bcells_Human0.85905435
146ZFP281_27345836_Chip-Seq_ESCs_Mouse0.85623291
147PRDM14_20953172_ChIP-Seq_ESCs_Human0.85145008
148WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.84420873
149SMAD4_21741376_ChIP-Seq_EPCs_Human0.83983258

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.02258516
2* MP0003635_abnormal_synaptic_transmissio4.00849846
3MP0003880_abnormal_central_pattern3.79558162
4MP0009046_muscle_twitch3.58895002
5* MP0009745_abnormal_behavioral_response3.22051647
6MP0005423_abnormal_somatic_nervous3.19238685
7MP0000749_muscle_degeneration3.14348525
8* MP0002064_seizures3.00296682
9* MP0002063_abnormal_learning/memory/cond2.97261778
10MP0001968_abnormal_touch/_nociception2.97109327
11MP0004270_analgesia2.95794618
12MP0002735_abnormal_chemical_nociception2.72661866
13* MP0002572_abnormal_emotion/affect_behav2.70464126
14MP0002837_dystrophic_cardiac_calcinosis2.60821946
15* MP0002272_abnormal_nervous_system2.57071390
16MP0002736_abnormal_nociception_after2.52408055
17MP0002734_abnormal_mechanical_nocicepti2.52236928
18MP0003787_abnormal_imprinting2.51505646
19MP0001486_abnormal_startle_reflex2.45137124
20MP0004130_abnormal_muscle_cell2.35429454
21MP0002234_abnormal_pharynx_morphology2.15602957
22MP0004147_increased_porphyrin_level2.13237447
23MP0002822_catalepsy2.12526812
24MP0001529_abnormal_vocalization2.10384898
25MP0008569_lethality_at_weaning2.10366133
26* MP0002106_abnormal_muscle_physiology2.06252995
27* MP0004036_abnormal_muscle_relaxation2.05554366
28* MP0001440_abnormal_grooming_behavior2.01837812
29MP0002067_abnormal_sensory_capabilities2.00015924
30* MP0002184_abnormal_innervation1.99934422
31MP0001970_abnormal_pain_threshold1.96986898
32MP0004145_abnormal_muscle_electrophysio1.93546431
33MP0002332_abnormal_exercise_endurance1.91218162
34MP0002733_abnormal_thermal_nociception1.85868087
35* MP0001501_abnormal_sleep_pattern1.84825829
36MP0003122_maternal_imprinting1.83618937
37MP0003879_abnormal_hair_cell1.81413523
38MP0006276_abnormal_autonomic_nervous1.78893401
39* MP0005369_muscle_phenotype1.76852236
40* MP0002557_abnormal_social/conspecific_i1.76407545
41* MP0004811_abnormal_neuron_physiology1.72170283
42MP0004924_abnormal_behavior1.71533979
43MP0005386_behavior/neurological_phenoty1.71533979
44MP0002653_abnormal_ependyma_morphology1.70616306
45MP0000778_abnormal_nervous_system1.68895178
46MP0009780_abnormal_chondrocyte_physiolo1.67464328
47MP0003195_calcinosis1.66599659
48MP0002909_abnormal_adrenal_gland1.62090876
49* MP0000955_abnormal_spinal_cord1.60151405
50MP0001502_abnormal_circadian_rhythm1.51853599
51MP0004885_abnormal_endolymph1.51498429
52MP0000372_irregular_coat_pigmentation1.51376437
53MP0005646_abnormal_pituitary_gland1.51111951
54MP0002876_abnormal_thyroid_physiology1.48441634
55MP0000750_abnormal_muscle_regeneration1.46454546
56MP0004142_abnormal_muscle_tone1.44441597
57* MP0002066_abnormal_motor_capabilities/c1.40033405
58MP0002638_abnormal_pupillary_reflex1.38179602
59* MP0005645_abnormal_hypothalamus_physiol1.37608509
60MP0000751_myopathy1.36677340
61* MP0002882_abnormal_neuron_morphology1.34604687
62MP0006036_abnormal_mitochondrial_physio1.33175344
63MP0000569_abnormal_digit_pigmentation1.31242932
64MP0004742_abnormal_vestibular_system1.29688049
65* MP0000759_abnormal_skeletal_muscle1.29317871
66MP0004087_abnormal_muscle_fiber1.29074365
67MP0002102_abnormal_ear_morphology1.27619121
68MP0002269_muscular_atrophy1.27227454
69MP0001986_abnormal_taste_sensitivity1.25872935
70MP0003329_amyloid_beta_deposits1.25864684
71MP0005266_abnormal_metabolism1.25105423
72MP0005253_abnormal_eye_physiology1.24638258
73MP0001984_abnormal_olfaction1.18879798
74MP0008877_abnormal_DNA_methylation1.18879784
75* MP0004858_abnormal_nervous_system1.18023787
76* MP0004084_abnormal_cardiac_muscle1.15836779
77MP0000566_synostosis1.14884014
78MP0005670_abnormal_white_adipose1.13865194
79MP0003137_abnormal_impulse_conducting1.11038117
80MP0004133_heterotaxia1.08717130
81MP0003123_paternal_imprinting1.08716952
82MP0003136_yellow_coat_color1.06332951
83MP0001188_hyperpigmentation1.04307455
84MP0002108_abnormal_muscle_morphology1.03097293
85* MP0002152_abnormal_brain_morphology1.02369285
86MP0000427_abnormal_hair_cycle1.02004615
87MP0002751_abnormal_autonomic_nervous1.01496656
88* MP0002069_abnormal_eating/drinking_beha1.01097597
89MP0003950_abnormal_plasma_membrane0.98339671
90MP0000383_abnormal_hair_follicle0.97528226
91MP0001485_abnormal_pinna_reflex0.97129763
92* MP0003633_abnormal_nervous_system0.96247961
93MP0003283_abnormal_digestive_organ0.96221569
94MP0008961_abnormal_basal_metabolism0.94464603
95* MP0003631_nervous_system_phenotype0.91522648
96MP0001963_abnormal_hearing_physiology0.90177942
97MP0008875_abnormal_xenobiotic_pharmacok0.89044579
98* MP0002972_abnormal_cardiac_muscle0.87717853
99MP0002229_neurodegeneration0.84678871
100MP0003632_abnormal_nervous_system0.84049661
101MP0003121_genomic_imprinting0.83926048
102* MP0000230_abnormal_systemic_arterial0.81763392
103MP0005330_cardiomyopathy0.81368612
104MP0003011_delayed_dark_adaptation0.81360939
105* MP0002752_abnormal_somatic_nervous0.79461388
106* MP0008872_abnormal_physiological_respon0.78481153
107MP0003878_abnormal_ear_physiology0.78151146
108MP0005377_hearing/vestibular/ear_phenot0.78151146
109MP0001177_atelectasis0.77585569
110MP0005394_taste/olfaction_phenotype0.77571021
111MP0005499_abnormal_olfactory_system0.77571021
112MP0005623_abnormal_meninges_morphology0.76220850
113MP0006292_abnormal_olfactory_placode0.76156073
114MP0000747_muscle_weakness0.74679645
115* MP0008874_decreased_physiological_sensi0.74577380
116MP0005389_reproductive_system_phenotype0.74030017
117MP0002938_white_spotting0.73804215
118* MP0004484_altered_response_of0.73778193
119MP0001905_abnormal_dopamine_level0.73660985
120MP0005174_abnormal_tail_pigmentation0.70994984
121MP0001919_abnormal_reproductive_system0.70771710
122MP0010386_abnormal_urinary_bladder0.68696517
123MP0000631_abnormal_neuroendocrine_gland0.68638283
124* MP0003646_muscle_fatigue0.66917588
125MP0001299_abnormal_eye_distance/0.65485789
126* MP0004085_abnormal_heartbeat0.64517147
127* MP0001664_abnormal_digestion0.64491308
128MP0006072_abnormal_retinal_apoptosis0.64025135
129MP0004215_abnormal_myocardial_fiber0.63922674
130MP0003634_abnormal_glial_cell0.62061632
131MP0000534_abnormal_ureter_morphology0.60030319
132MP0000678_abnormal_parathyroid_gland0.59570460
133* MP0010769_abnormal_survival0.58413867
134MP0005551_abnormal_eye_electrophysiolog0.57860587
135MP0003690_abnormal_glial_cell0.56135977
136MP0000639_abnormal_adrenal_gland0.55444738
137* MP0010768_mortality/aging0.54969466
138* MP0005620_abnormal_muscle_contractility0.54766495
139* MP0003861_abnormal_nervous_system0.54630757
140MP0000013_abnormal_adipose_tissue0.54622304

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.22125052
2Muscle fiber inclusion bodies (HP:0100299)6.99515801
3Nemaline bodies (HP:0003798)6.77517632
4Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)6.58427835
5Myokymia (HP:0002411)6.21005535
6Focal seizures (HP:0007359)5.30084995
7Visual hallucinations (HP:0002367)5.09477176
8Progressive cerebellar ataxia (HP:0002073)4.65927194
9Exercise-induced muscle cramps (HP:0003710)4.63879027
10Muscle hypertrophy of the lower extremities (HP:0008968)4.61016832
11Action tremor (HP:0002345)4.52674991
12Febrile seizures (HP:0002373)4.46704504
13Type 1 muscle fiber predominance (HP:0003803)4.44417601
14Calf muscle hypertrophy (HP:0008981)4.17342739
15Epileptic encephalopathy (HP:0200134)4.02656805
16Atonic seizures (HP:0010819)3.96807060
17Generalized tonic-clonic seizures (HP:0002069)3.80727280
18Absence seizures (HP:0002121)3.66845824
19Distal arthrogryposis (HP:0005684)3.56849728
20Pheochromocytoma (HP:0002666)3.52195529
21Pancreatic cysts (HP:0001737)3.30167256
22Dialeptic seizures (HP:0011146)3.27936188
23Broad-based gait (HP:0002136)3.26276094
24Gaze-evoked nystagmus (HP:0000640)3.24730465
25Dysdiadochokinesis (HP:0002075)3.17452110
26Congenital stationary night blindness (HP:0007642)3.15955250
27Depression (HP:0000716)3.15143687
28Fetal akinesia sequence (HP:0001989)3.10789606
29Neuroendocrine neoplasm (HP:0100634)3.07954294
30Myopathic facies (HP:0002058)3.04389400
31Amblyopia (HP:0000646)3.04272802
32Impaired vibration sensation in the lower limbs (HP:0002166)3.04014489
33Failure to thrive in infancy (HP:0001531)3.01408147
34Genetic anticipation (HP:0003743)2.99933348
35Ankle clonus (HP:0011448)2.95821382
36Type II lissencephaly (HP:0007260)2.95503821
37Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.92876271
38Poor eye contact (HP:0000817)2.90749217
39Supranuclear gaze palsy (HP:0000605)2.89596546
40Abnormality of calcium-phosphate metabolism (HP:0100530)2.86641770
41Abnormality of the renal cortex (HP:0011035)2.85018517
42Anxiety (HP:0000739)2.82499941
43Truncal ataxia (HP:0002078)2.78491954
44Frequent falls (HP:0002359)2.78305424
45Abnormality of the calf musculature (HP:0001430)2.77489005
46Urinary bladder sphincter dysfunction (HP:0002839)2.76073709
47Abnormal eating behavior (HP:0100738)2.75294765
48Pancreatic fibrosis (HP:0100732)2.75265423
49Nephronophthisis (HP:0000090)2.73359779
50Rimmed vacuoles (HP:0003805)2.72853197
51Dysmetria (HP:0001310)2.72635699
52Agitation (HP:0000713)2.69159466
53Absent phalangeal crease (HP:0006109)2.68808514
54Impaired smooth pursuit (HP:0007772)2.65810702
55Impaired social interactions (HP:0000735)2.65323190
56Abnormal social behavior (HP:0012433)2.65323190
57Polydipsia (HP:0001959)2.64651037
58Abnormal drinking behavior (HP:0030082)2.64651037
59EMG: myopathic abnormalities (HP:0003458)2.63925107
60Myoglobinuria (HP:0002913)2.63838071
61Postural instability (HP:0002172)2.63703265
62Molar tooth sign on MRI (HP:0002419)2.62536455
63Abnormality of midbrain morphology (HP:0002418)2.62536455
64Hypoventilation (HP:0002791)2.56047661
65Mutism (HP:0002300)2.55462717
66Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.49971901
67Abnormality of alanine metabolism (HP:0010916)2.49971901
68Hyperalaninemia (HP:0003348)2.49971901
69Ventricular fibrillation (HP:0001663)2.47968347
70Round ear (HP:0100830)2.46019632
71True hermaphroditism (HP:0010459)2.45422374
72Abnormality of the renal medulla (HP:0100957)2.44043374
73Abnormality of ocular smooth pursuit (HP:0000617)2.40492608
74Abnormality of the lower motor neuron (HP:0002366)2.38288986
75Tubular atrophy (HP:0000092)2.38118584
76Abnormality of the corticospinal tract (HP:0002492)2.36646176
77Dysmetric saccades (HP:0000641)2.36364520
78Abnormal finger flexion creases (HP:0006143)2.34930749
79Rhabdomyolysis (HP:0003201)2.34379937
80Urinary urgency (HP:0000012)2.34152414
81Hypercortisolism (HP:0001578)2.32254595
82Hemiparesis (HP:0001269)2.31744751
83Hyporeflexia of lower limbs (HP:0002600)2.30151253
84Muscle fiber splitting (HP:0003555)2.29569027
85Diplopia (HP:0000651)2.29305448
86Abnormality of binocular vision (HP:0011514)2.29305448
87Hyperkalemia (HP:0002153)2.24834897
88Intention tremor (HP:0002080)2.24799830
89Annular pancreas (HP:0001734)2.23724231
90Ulnar deviation of the wrist (HP:0003049)2.22865044
91Attenuation of retinal blood vessels (HP:0007843)2.22825205
92Hemiplegia (HP:0002301)2.22616507
93Scanning speech (HP:0002168)2.21423947
94Exercise-induced myalgia (HP:0003738)2.21190151
95Large for gestational age (HP:0001520)2.21056235
96Hyperventilation (HP:0002883)2.20908106
97Depressed nasal tip (HP:0000437)2.20839966
98Neoplasm of the peripheral nervous system (HP:0100007)2.17779595
99Spastic gait (HP:0002064)2.17731617
100Hyperphosphatemia (HP:0002905)2.15913149
101Inability to walk (HP:0002540)2.14993631
102Cerebellar dysplasia (HP:0007033)2.14958005
103Areflexia of lower limbs (HP:0002522)2.13483061
104Chronic hepatic failure (HP:0100626)2.12595063
105Lissencephaly (HP:0001339)2.07033328
106Subaortic stenosis (HP:0001682)2.05125307
107Abnormality of the left ventricular outflow tract (HP:0011103)2.05125307
108Excessive salivation (HP:0003781)2.04214143
109Drooling (HP:0002307)2.04214143
110Menstrual irregularities (HP:0000858)2.03441598
111Stereotypic behavior (HP:0000733)2.03244612
112Fatigable weakness (HP:0003473)2.03094404
113Abnormality of the neuromuscular junction (HP:0003398)2.03094404
114Bradykinesia (HP:0002067)2.02052102
115Neck muscle weakness (HP:0000467)2.01604912
116Impaired vibratory sensation (HP:0002495)2.01018528
117Status epilepticus (HP:0002133)2.00496178
118Absent speech (HP:0001344)2.00443982
119Epileptiform EEG discharges (HP:0011182)2.00016414
120Horizontal nystagmus (HP:0000666)1.99358315
121Polyphagia (HP:0002591)1.98800429
122Medial flaring of the eyebrow (HP:0010747)1.96545052
123Pointed chin (HP:0000307)1.96020413
124Hyperthyroidism (HP:0000836)1.94727546
125Polyuria (HP:0000103)1.93201995
126Incomplete penetrance (HP:0003829)1.91924298
127Abnormality of the labia minora (HP:0012880)1.90586961
128EEG with generalized epileptiform discharges (HP:0011198)1.90238858
129Ketoacidosis (HP:0001993)1.90077866
130Cystic liver disease (HP:0006706)1.87458092
131Torticollis (HP:0000473)1.86286513
132Malignant hyperthermia (HP:0002047)1.84928261
133Progressive inability to walk (HP:0002505)1.83662226
134Abnormal EKG (HP:0003115)1.82798616
135Hypsarrhythmia (HP:0002521)1.82724245
136Insomnia (HP:0100785)1.82422855
137Renal cortical cysts (HP:0000803)1.82135913
138Hyperglycinuria (HP:0003108)1.81310774
139Psychosis (HP:0000709)1.81222949
140Generalized myoclonic seizures (HP:0002123)1.80757427
141Lower limb muscle weakness (HP:0007340)1.79146440
142Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.78669250
143Severe muscular hypotonia (HP:0006829)1.78470064
144Exotropia (HP:0000577)1.77422214
145Difficulty running (HP:0009046)1.77303932
146Abnormality of saccadic eye movements (HP:0000570)1.76597135
147Focal dystonia (HP:0004373)1.76356052
148Pendular nystagmus (HP:0012043)1.75653787
149Type 2 muscle fiber atrophy (HP:0003554)1.75146113
150Calcaneovalgus deformity (HP:0001848)1.75086215
151Unilateral renal agenesis (HP:0000122)1.74642821
152Gait ataxia (HP:0002066)1.74047951
153Aqueductal stenosis (HP:0002410)1.73750720
154Tetraplegia (HP:0002445)1.73087300
155Muscular dystrophy (HP:0003560)1.72783348
156Postural tremor (HP:0002174)1.72420242
157Bundle branch block (HP:0011710)1.72217108
158Ketosis (HP:0001946)1.71600107
159Anterior segment dysgenesis (HP:0007700)1.71065822
160Generalized muscle weakness (HP:0003324)1.70935813
161Resting tremor (HP:0002322)1.70875646
162Lower limb amyotrophy (HP:0007210)1.70184548
163Narrow nasal bridge (HP:0000446)1.69644109
164Congenital sensorineural hearing impairment (HP:0008527)1.69194245
165Decreased central vision (HP:0007663)1.69010096
166Absent/shortened dynein arms (HP:0200106)1.68091118
167Dynein arm defect of respiratory motile cilia (HP:0012255)1.68091118
168Myotonia (HP:0002486)1.67863392
169Pachygyria (HP:0001302)1.67194405
170Acute necrotizing encephalopathy (HP:0006965)1.66819193
171Keratoconus (HP:0000563)1.65900115
172Increased corneal curvature (HP:0100692)1.65900115
173Clumsiness (HP:0002312)1.65813130
174Weak cry (HP:0001612)1.65630454
175Nonprogressive disorder (HP:0003680)1.65242087
176Anosmia (HP:0000458)1.65146284
177Congenital hepatic fibrosis (HP:0002612)1.65079406
178Abnormality of potassium homeostasis (HP:0011042)1.65065030
179Popliteal pterygium (HP:0009756)1.64900683
180Abnormality of the aortic arch (HP:0012303)1.64711120
181Deformed tarsal bones (HP:0008119)1.64393425
182Decreased circulating renin level (HP:0003351)1.62111046

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN6.06882301
2NTRK34.54436065
3FRK4.52555107
4MAP3K93.91010324
5MAP3K43.56202714
6EPHA43.24080647
7MAP2K72.96208126
8MARK12.68865175
9MINK12.51475355
10NTRK22.45565081
11ADRBK22.44153841
12WNK42.42748052
13MAP2K42.35841512
14MAP3K122.24673655
15BMPR1B2.19326684
16NTRK12.17502426
17STK392.11397481
18ACVR1B1.98468008
19PAK61.98365612
20DAPK21.96918789
21ZAK1.94600662
22MAP4K21.93468673
23SIK21.90209620
24CAMKK11.85836174
25GRK11.82177539
26WNK31.81180066
27PRKD31.76239231
28STK381.73651464
29TAOK31.68711317
30SIK31.64526442
31KSR21.63451209
32PRPF4B1.63343340
33CASK1.62358216
34MAPKAPK31.61255413
35STK241.58059624
36PIK3CG1.56630338
37INSRR1.53416943
38PHKG11.50552080
39PHKG21.50552080
40TTN1.50461995
41LATS21.47816053
42TNIK1.46753388
43MUSK1.46231135
44CCNB11.45886429
45ALK1.45352490
46MAPK131.42333785
47TLK11.37168435
48NUAK11.33228056
49CAMKK21.29375688
50GRK51.27048850
51CDK51.26844648
52NEK11.26523807
53PRKCG1.25805277
54SGK21.24799670
55DAPK11.18701691
56PLK21.17744881
57SGK2231.16089809
58SGK4941.16089809
59FES1.15323044
60OXSR11.14854459
61KSR11.13317204
62RET1.11875178
63SGK31.08708239
64GRK71.03178546
65RIPK41.00511839
66PINK11.00497580
67PNCK0.99914239
68TYRO30.94917047
69ADRBK10.94182853
70ARAF0.92742584
71NME10.90210277
72MARK20.89976844
73TIE10.88872401
74UHMK10.88431182
75TRPM70.87537597
76MAP3K130.83765391
77CDK190.81881219
78MAPK120.81666402
79TNK20.81230986
80WNK10.81029815
81STK110.79669543
82LMTK20.79404745
83PRKAA20.79027994
84PKN10.78992939
85* CAMK10.78629482
86* CAMK2A0.77703138
87AKT30.76669581
88SGK10.75163088
89TAOK10.74517368
90PRKAA10.74336942
91PRKCH0.72836958
92STK38L0.71771095
93BCKDK0.70850046
94MKNK20.70512105
95TXK0.66833505
96PRKCQ0.66721511
97CDK180.65693198
98SIK10.65516319
99MAPKAPK50.65308101
100CDK150.64787428
101TGFBR10.63557293
102DYRK1A0.62577795
103PTK20.62211267
104PIK3CA0.62068412
105MAP3K20.62034719
106PTK2B0.61916395
107CAMK2B0.58862641
108RPS6KA20.57410198
109MAPK100.57237969
110CDK140.55936154
111ERBB30.55908429
112CDK11A0.55752694
113CDC42BPA0.53611706
114MAP3K60.53121609
115RPS6KA30.52977509
116CAMK1G0.51531485
117RIPK10.49096739
118EEF2K0.48623271
119* PRKACA0.48075721
120DDR20.48067785
121CAMK2G0.47719149
122PDK10.47511901
123DYRK20.46353182
124RAF10.45854440
125MAP3K70.43852203
126MAP3K10.42364645
127PRKCE0.42127518
128FER0.42007346
129PDPK10.39304784
130NEK60.38010136
131MAPK80.37635005
132MAP2K10.37155696
133CSNK1A10.36388857
134BMPR20.36146534
135MAP2K60.36023449
136BRAF0.35776195
137PDGFRA0.35579535
138PAK30.35116577
139BRSK10.34609131
140FYN0.34265895
141PRKG10.33768183
142CSNK1G20.32995494
143PRKCZ0.32278144
144CAMK2D0.31044640
145RPS6KB10.30825325
146* PRKCA0.29042702
147CSNK1G10.28086438
148FGFR20.28065374
149CSNK1D0.26772576
150CAMK1D0.26767621
151TRIM280.26729328
152LIMK10.25572705
153PRKACB0.22674614
154MAPK110.21098794
155NLK0.20957867
156ROCK10.20172833

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.90266783
2Synaptic vesicle cycle_Homo sapiens_hsa047213.19131109
3Nitrogen metabolism_Homo sapiens_hsa009102.78494559
4GABAergic synapse_Homo sapiens_hsa047272.69147764
5Olfactory transduction_Homo sapiens_hsa047402.62562344
6* Circadian entrainment_Homo sapiens_hsa047132.62015017
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.59749334
8Glutamatergic synapse_Homo sapiens_hsa047242.57255324
9Long-term potentiation_Homo sapiens_hsa047202.52863634
10Morphine addiction_Homo sapiens_hsa050322.50098955
11Linoleic acid metabolism_Homo sapiens_hsa005912.35144125
12Butanoate metabolism_Homo sapiens_hsa006502.25176439
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.24665228
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.18956501
15Amphetamine addiction_Homo sapiens_hsa050312.14579805
16* Salivary secretion_Homo sapiens_hsa049702.12982975
17Taste transduction_Homo sapiens_hsa047422.03824551
18Insulin secretion_Homo sapiens_hsa049111.98592015
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.94693123
20Dopaminergic synapse_Homo sapiens_hsa047281.92236806
21Gastric acid secretion_Homo sapiens_hsa049711.92039452
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.87469045
23* Long-term depression_Homo sapiens_hsa047301.86453868
24Cholinergic synapse_Homo sapiens_hsa047251.83966601
25* Calcium signaling pathway_Homo sapiens_hsa040201.80907652
26Propanoate metabolism_Homo sapiens_hsa006401.73332425
27Oxidative phosphorylation_Homo sapiens_hsa001901.70436257
28Oxytocin signaling pathway_Homo sapiens_hsa049211.68874547
29Tryptophan metabolism_Homo sapiens_hsa003801.64714939
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.64648389
31Renin secretion_Homo sapiens_hsa049241.62911443
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.62502689
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.56420705
34Serotonergic synapse_Homo sapiens_hsa047261.54140476
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.52976926
36GnRH signaling pathway_Homo sapiens_hsa049121.48742616
37Ether lipid metabolism_Homo sapiens_hsa005651.47728087
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.46898822
39Parkinsons disease_Homo sapiens_hsa050121.46050961
40Type II diabetes mellitus_Homo sapiens_hsa049301.45788610
41Selenocompound metabolism_Homo sapiens_hsa004501.41292212
42Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.38244857
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.38033873
44cAMP signaling pathway_Homo sapiens_hsa040241.37648212
45ABC transporters_Homo sapiens_hsa020101.35267093
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.35097723
47Cocaine addiction_Homo sapiens_hsa050301.34092661
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.33832394
49Gap junction_Homo sapiens_hsa045401.33008259
50Phosphatidylinositol signaling system_Homo sapiens_hsa040701.31072854
51Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.26819190
52Collecting duct acid secretion_Homo sapiens_hsa049661.26252435
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.21519256
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.17648848
55Alzheimers disease_Homo sapiens_hsa050101.13037065
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.12541403
57Estrogen signaling pathway_Homo sapiens_hsa049151.12455960
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.11280912
59ErbB signaling pathway_Homo sapiens_hsa040121.06551284
60cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05382727
61beta-Alanine metabolism_Homo sapiens_hsa004101.03625024
62Axon guidance_Homo sapiens_hsa043601.02155108
63Glioma_Homo sapiens_hsa052141.00535460
64Vascular smooth muscle contraction_Homo sapiens_hsa042701.00384995
65Melanogenesis_Homo sapiens_hsa049160.99199982
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.99130208
67Huntingtons disease_Homo sapiens_hsa050160.94779375
68Peroxisome_Homo sapiens_hsa041460.93438063
69Histidine metabolism_Homo sapiens_hsa003400.93364312
70Oocyte meiosis_Homo sapiens_hsa041140.91309801
71Dilated cardiomyopathy_Homo sapiens_hsa054140.90674334
72* Arginine and proline metabolism_Homo sapiens_hsa003300.89658221
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.89542280
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.89283222
75Regulation of autophagy_Homo sapiens_hsa041400.85875571
76Cardiac muscle contraction_Homo sapiens_hsa042600.85101886
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84846578
78Pancreatic secretion_Homo sapiens_hsa049720.83592271
79Lysine degradation_Homo sapiens_hsa003100.82765410
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.82469417
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.81813713
82Thyroid hormone synthesis_Homo sapiens_hsa049180.81729501
83Vibrio cholerae infection_Homo sapiens_hsa051100.81521578
84RNA polymerase_Homo sapiens_hsa030200.81454698
85Homologous recombination_Homo sapiens_hsa034400.81314981
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80229963
87Choline metabolism in cancer_Homo sapiens_hsa052310.79723659
88Caffeine metabolism_Homo sapiens_hsa002320.79062539
89Dorso-ventral axis formation_Homo sapiens_hsa043200.78263447
90MAPK signaling pathway_Homo sapiens_hsa040100.77525218
91mTOR signaling pathway_Homo sapiens_hsa041500.77423883
92Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.76906595
93Glycerolipid metabolism_Homo sapiens_hsa005610.76770178
94Fanconi anemia pathway_Homo sapiens_hsa034600.75192826
95Arachidonic acid metabolism_Homo sapiens_hsa005900.74533351
96Fatty acid degradation_Homo sapiens_hsa000710.73896806
97Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.73061587
98Chemical carcinogenesis_Homo sapiens_hsa052040.71749486
99Type I diabetes mellitus_Homo sapiens_hsa049400.71735855
100Ovarian steroidogenesis_Homo sapiens_hsa049130.70584536
101Glucagon signaling pathway_Homo sapiens_hsa049220.70580084
102Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.69969924
103Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69559427
104Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.68394050
105Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68305055
106Basal transcription factors_Homo sapiens_hsa030220.68201349
107Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.67030878
108One carbon pool by folate_Homo sapiens_hsa006700.66940287
109Neurotrophin signaling pathway_Homo sapiens_hsa047220.66679302
110* Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65413497
1112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.65363724
112Circadian rhythm_Homo sapiens_hsa047100.64349893
113Inositol phosphate metabolism_Homo sapiens_hsa005620.63023180
114Retinol metabolism_Homo sapiens_hsa008300.59640330
115Rap1 signaling pathway_Homo sapiens_hsa040150.59490235
116Ras signaling pathway_Homo sapiens_hsa040140.58552442
117RNA degradation_Homo sapiens_hsa030180.58147959
118Fat digestion and absorption_Homo sapiens_hsa049750.57229394
119Cyanoamino acid metabolism_Homo sapiens_hsa004600.57115296
120Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56988974
121Insulin signaling pathway_Homo sapiens_hsa049100.54083964
122Purine metabolism_Homo sapiens_hsa002300.53738942
123Intestinal immune network for IgA production_Homo sapiens_hsa046720.52858871
124Starch and sucrose metabolism_Homo sapiens_hsa005000.52759981
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50574265
126Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.49522022
127Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48745749
128Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48688851
129Bile secretion_Homo sapiens_hsa049760.48507742
130Non-small cell lung cancer_Homo sapiens_hsa052230.48401129
131Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48337564
132* Metabolic pathways_Homo sapiens_hsa011000.48062159
133Wnt signaling pathway_Homo sapiens_hsa043100.47984468
134Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47954570
135Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.47215047
136Fatty acid metabolism_Homo sapiens_hsa012120.45883580
137AMPK signaling pathway_Homo sapiens_hsa041520.45850986
138VEGF signaling pathway_Homo sapiens_hsa043700.45538362
139Renal cell carcinoma_Homo sapiens_hsa052110.44578750
140Sphingolipid signaling pathway_Homo sapiens_hsa040710.44528812
141Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44327884
142Endocytosis_Homo sapiens_hsa041440.42223322
143Phototransduction_Homo sapiens_hsa047440.39095034
144Central carbon metabolism in cancer_Homo sapiens_hsa052300.38342888
145Endometrial cancer_Homo sapiens_hsa052130.37983851
146Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36595414
147Alcoholism_Homo sapiens_hsa050340.36210080
148Hedgehog signaling pathway_Homo sapiens_hsa043400.32762467
149Melanoma_Homo sapiens_hsa052180.30797644
150Mineral absorption_Homo sapiens_hsa049780.30755500
151Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30426378
152Glycerophospholipid metabolism_Homo sapiens_hsa005640.29553286
153Prolactin signaling pathway_Homo sapiens_hsa049170.28944704
154Chemokine signaling pathway_Homo sapiens_hsa040620.27971114
155Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.27742024
156Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27521191
157Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.27055115

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