NOL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an anti-apoptotic protein that has been shown to down-regulate the enzyme activities of caspase 2, caspase 8 and tumor protein p53. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)3.97404603
2L-phenylalanine metabolic process (GO:0006558)3.70798758
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.70798758
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.64529593
54-hydroxyproline metabolic process (GO:0019471)3.61509893
6positive regulation of action potential (GO:0045760)3.60521172
7creatine metabolic process (GO:0006600)3.56689463
8neuronal action potential propagation (GO:0019227)3.53968773
9presynaptic membrane assembly (GO:0097105)3.43204675
10regulation of cell communication by electrical coupling (GO:0010649)3.42980608
11positive regulation of fatty acid oxidation (GO:0046321)3.41392495
12gluconeogenesis (GO:0006094)3.36343560
13sarcomere organization (GO:0045214)3.33187170
14actin-mediated cell contraction (GO:0070252)3.31448992
15fructose metabolic process (GO:0006000)3.30323056
16sarcoplasmic reticulum calcium ion transport (GO:0070296)3.30017122
17endothelial cell chemotaxis (GO:0035767)3.29104724
18* response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.27787576
19negative regulation of protein localization to cell surface (GO:2000009)3.26601631
20long-chain fatty acid biosynthetic process (GO:0042759)3.24446241
21hexose biosynthetic process (GO:0019319)3.23702858
22axon ensheathment in central nervous system (GO:0032291)3.22105580
23central nervous system myelination (GO:0022010)3.22105580
24positive regulation of fatty acid beta-oxidation (GO:0032000)3.20744952
25NADH metabolic process (GO:0006734)3.20471051
26presynaptic membrane organization (GO:0097090)3.19694368
27regulation of fatty acid oxidation (GO:0046320)3.18339533
28membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.18049014
29negative regulation of synaptic transmission, GABAergic (GO:0032229)3.12705879
30vocalization behavior (GO:0071625)3.12500412
31regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.11752159
32negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.10855595
33striated muscle contraction (GO:0006941)3.08661609
34regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.06887478
35limb bud formation (GO:0060174)3.06568543
36GDP-mannose metabolic process (GO:0019673)3.03982847
37righting reflex (GO:0060013)3.01052620
38neuronal action potential (GO:0019228)2.99105573
39erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.98683730
40L-phenylalanine catabolic process (GO:0006559)2.98683730
41response to muscle activity (GO:0014850)2.98594782
42postsynaptic membrane organization (GO:0001941)2.97265703
43response to epinephrine (GO:0071871)2.96986107
44glycogen catabolic process (GO:0005980)2.96215809
45plasma membrane repair (GO:0001778)2.96113175
46neuron recognition (GO:0008038)2.95993670
47regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.92907411
48ionotropic glutamate receptor signaling pathway (GO:0035235)2.89989429
49cellular response to epinephrine stimulus (GO:0071872)2.89839066
50skeletal muscle fiber development (GO:0048741)2.87966817
51desmosome organization (GO:0002934)2.87790213
52detection of calcium ion (GO:0005513)2.86575929
53monosaccharide biosynthetic process (GO:0046364)2.85736278
54cerebral cortex radially oriented cell migration (GO:0021799)2.85483361
55regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.85127290
56skeletal muscle adaptation (GO:0043501)2.84800889
57negative regulation of cell size (GO:0045792)2.82896782
58myofibril assembly (GO:0030239)2.82216348
59startle response (GO:0001964)2.80029005
60regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.79821278
61positive regulation of protein kinase C signaling (GO:0090037)2.79472343
62protein localization to synapse (GO:0035418)2.79425920
63neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.78169781
64sympathetic nervous system development (GO:0048485)2.73899277
65regulation of fatty acid beta-oxidation (GO:0031998)2.73819324
66regulation of relaxation of muscle (GO:1901077)2.73089026
67regulation of sequestering of triglyceride (GO:0010889)2.71717544
68positive regulation of vascular permeability (GO:0043117)2.71396223
69photoreceptor cell differentiation (GO:0046530)2.70171240
70eye photoreceptor cell differentiation (GO:0001754)2.70171240
71positive regulation of synapse assembly (GO:0051965)2.69678674
72glutamate receptor signaling pathway (GO:0007215)2.68400275
73cardiac muscle contraction (GO:0060048)2.68175584
74positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.68024667
75peptidyl-proline hydroxylation (GO:0019511)2.67701252
76myotube cell development (GO:0014904)2.66856035
77transmission of nerve impulse (GO:0019226)2.65136426
78glycolytic process (GO:0006096)2.65017819
79calcium-mediated signaling using intracellular calcium source (GO:0035584)2.64693207
80protein hydroxylation (GO:0018126)2.64599544
81regulation of action potential (GO:0098900)2.64488542
82regulation of actin filament-based movement (GO:1903115)2.62947486
83regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.62620643
84membrane depolarization during action potential (GO:0086010)2.61818048
85respiratory electron transport chain (GO:0022904)2.61202546
86regulation of respiratory system process (GO:0044065)2.60259085
87glucan catabolic process (GO:0009251)2.59855391
88cardiac ventricle formation (GO:0003211)2.59529517
89protein carboxylation (GO:0018214)2.57861107
90peptidyl-glutamic acid carboxylation (GO:0017187)2.57861107
91cell migration in hindbrain (GO:0021535)2.56482439
92neuron remodeling (GO:0016322)2.55964328
93regulation of membrane repolarization (GO:0060306)2.55869906
94cardiac chamber formation (GO:0003207)2.55677505
95positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.54553128
96electron transport chain (GO:0022900)2.54536411
97muscle contraction (GO:0006936)2.53810048
982-oxoglutarate metabolic process (GO:0006103)2.53801521
99dendritic spine morphogenesis (GO:0060997)2.52475424
100regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.51858159
101retina layer formation (GO:0010842)2.51502377
102regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.50663299
103positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.49759430
104regulation of cardiac muscle contraction (GO:0055117)2.49599293
105myelin maintenance (GO:0043217)2.48809235
106actomyosin structure organization (GO:0031032)2.48585938
107positive regulation of glycogen biosynthetic process (GO:0045725)2.48424745
108regulation of synapse assembly (GO:0051963)2.48147719
109regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.47574867
110tricarboxylic acid cycle (GO:0006099)2.46667375
111cardiac myofibril assembly (GO:0055003)2.46543094
112oxaloacetate metabolic process (GO:0006107)2.45672828
113regulation of respiratory gaseous exchange (GO:0043576)2.45492462
114muscle cell cellular homeostasis (GO:0046716)2.45296714
115action potential (GO:0001508)2.44746884
116phosphate ion homeostasis (GO:0055062)2.44330518
117trivalent inorganic anion homeostasis (GO:0072506)2.44330518
118regulation of striated muscle contraction (GO:0006942)2.44142238
119proline biosynthetic process (GO:0006561)2.44046216
120regulation of skeletal muscle contraction (GO:0014819)2.43834387
121negative regulation of cardiac muscle hypertrophy (GO:0010614)2.43401467
122axonal fasciculation (GO:0007413)2.42491210
123positive regulation of glycogen metabolic process (GO:0070875)2.42450926
124short-term memory (GO:0007614)2.41602606
125membrane assembly (GO:0071709)2.36615427
126cranial nerve morphogenesis (GO:0021602)2.36596994
127negative regulation of muscle hypertrophy (GO:0014741)2.36484753
128positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.36073951
129regulation of cardiac muscle cell contraction (GO:0086004)2.35911659
130skeletal muscle contraction (GO:0003009)2.35881879
131neuromuscular synaptic transmission (GO:0007274)2.35128620
132spinal cord motor neuron differentiation (GO:0021522)2.35068301
133negative regulation of neurotransmitter transport (GO:0051589)2.34601560
134regulation of glutamate receptor signaling pathway (GO:1900449)2.33976933
135positive regulation of triglyceride biosynthetic process (GO:0010867)2.33763194
136proline metabolic process (GO:0006560)2.33746864
137neuronal ion channel clustering (GO:0045161)2.32191619
138actin-myosin filament sliding (GO:0033275)2.31800117
139muscle filament sliding (GO:0030049)2.31800117
140G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.31752838
141regulation of protein localization to cell surface (GO:2000008)2.31361331
142multicellular organismal signaling (GO:0035637)2.31342090
143negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.30891675
144muscle fiber development (GO:0048747)2.30613471
145positive regulation of potassium ion transmembrane transport (GO:1901381)2.30124993
146synaptic transmission, glutamatergic (GO:0035249)2.30082883
147regulation of triglyceride biosynthetic process (GO:0010866)2.29969338
148glycogen biosynthetic process (GO:0005978)2.29859298
149glucan biosynthetic process (GO:0009250)2.29859298
150cellular polysaccharide catabolic process (GO:0044247)2.29651588
151retinal ganglion cell axon guidance (GO:0031290)2.29530473
152peripheral nervous system neuron development (GO:0048935)2.29356639
153negative regulation of heart rate (GO:0010459)2.29301120
154negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.28729073
155neuron-neuron synaptic transmission (GO:0007270)2.28717857
156positive regulation of synaptic transmission, GABAergic (GO:0032230)2.28329503
157regulation of short-term neuronal synaptic plasticity (GO:0048172)2.28091760
158macroautophagy (GO:0016236)2.27986069
159energy coupled proton transport, down electrochemical gradient (GO:0015985)2.27769124
160ATP synthesis coupled proton transport (GO:0015986)2.27769124
161regulation of vesicle fusion (GO:0031338)2.27324886
162regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.27316818
163response to monoamine (GO:0071867)2.27001930
164response to catecholamine (GO:0071869)2.27001930
165regulation of the force of heart contraction (GO:0002026)2.26677967
166negative regulation of homotypic cell-cell adhesion (GO:0034111)2.26667466
167glucose metabolic process (GO:0006006)2.26555324
168galactose catabolic process (GO:0019388)2.25095288
169muscle system process (GO:0003012)2.22688820
170lung epithelium development (GO:0060428)2.22002304
171actin filament-based movement (GO:0030048)2.20953613
172pyruvate metabolic process (GO:0006090)2.20081483
173nitric oxide biosynthetic process (GO:0006809)2.19841160
174neurotransmitter catabolic process (GO:0042135)2.18795367
175cellular ketone body metabolic process (GO:0046950)2.18448432
176carnitine shuttle (GO:0006853)2.17223034
177response to inactivity (GO:0014854)2.17155839
178metanephric nephron epithelium development (GO:0072243)2.17118075
179negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.16599926
180striated muscle atrophy (GO:0014891)2.15553906
181behavioral response to nicotine (GO:0035095)2.15257501
182protein retention in ER lumen (GO:0006621)2.14370876
183response to misfolded protein (GO:0051788)2.13632196
184regulation of p38MAPK cascade (GO:1900744)2.13075914
185lung vasculature development (GO:0060426)2.12136402
186ubiquinone biosynthetic process (GO:0006744)2.10750758
187positive regulation of fatty acid metabolic process (GO:0045923)2.08448229

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.66053289
2GBX2_23144817_ChIP-Seq_PC3_Human3.62350436
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.49898701
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.48103091
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.32628793
6RARG_19884340_ChIP-ChIP_MEFs_Mouse3.15467691
7ESR2_21235772_ChIP-Seq_MCF-7_Human3.10019618
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.86494861
9* HIF1A_21447827_ChIP-Seq_MCF-7_Human2.75384686
10* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.72510384
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.68540827
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.63306914
13TRIM28_21343339_ChIP-Seq_HEK293_Human2.58365530
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.57924863
15RACK7_27058665_Chip-Seq_MCF-7_Human2.55243796
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.51084911
17ESR1_21235772_ChIP-Seq_MCF-7_Human2.48773065
18* LXR_22292898_ChIP-Seq_THP-1_Human2.48755971
19ZNF263_19887448_ChIP-Seq_K562_Human2.46411316
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.40731739
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.40689403
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.39743815
23EZH2_18974828_ChIP-Seq_MESCs_Mouse2.39680644
24RNF2_18974828_ChIP-Seq_MESCs_Mouse2.39680644
25SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.36077281
26JARID2_20075857_ChIP-Seq_MESCs_Mouse2.35568260
27BMI1_23680149_ChIP-Seq_NPCS_Mouse2.32262873
28ZFP57_27257070_Chip-Seq_ESCs_Mouse2.29075809
29TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.22689342
30TAF15_26573619_Chip-Seq_HEK293_Human2.20361910
31CBX2_27304074_Chip-Seq_ESCs_Mouse2.17642028
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.13948032
33EZH2_27294783_Chip-Seq_ESCs_Mouse2.13213629
34TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.09397985
35TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.08410182
36* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.03928428
37ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.03351805
38RXR_22158963_ChIP-Seq_LIVER_Mouse2.02424483
39SUZ12_27294783_Chip-Seq_ESCs_Mouse1.99625382
40P68_20966046_ChIP-Seq_HELA_Human1.97705459
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.97652237
42PPARA_22158963_ChIP-Seq_LIVER_Mouse1.96289205
43* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.95202666
44RNF2_27304074_Chip-Seq_ESCs_Mouse1.92146612
45CDX2_19796622_ChIP-Seq_MESCs_Mouse1.87861323
46CTCF_27219007_Chip-Seq_Bcells_Human1.85759109
47VDR_22108803_ChIP-Seq_LS180_Human1.85545377
48TET1_21451524_ChIP-Seq_MESCs_Mouse1.83804551
49TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.81161747
50* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.79414615
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.78342768
52ESR1_20079471_ChIP-ChIP_T-47D_Human1.78069120
53CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.77933875
54ERG_21242973_ChIP-ChIP_JURKAT_Human1.77171067
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.75555471
56GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.73777335
57AR_21572438_ChIP-Seq_LNCaP_Human1.72513581
58CTBP1_25329375_ChIP-Seq_LNCAP_Human1.69444260
59IGF1R_20145208_ChIP-Seq_DFB_Human1.68083518
60POU3F2_20337985_ChIP-ChIP_501MEL_Human1.66913087
61SMC4_20622854_ChIP-Seq_HELA_Human1.66565297
62P300_19829295_ChIP-Seq_ESCs_Human1.66286285
63CTBP2_25329375_ChIP-Seq_LNCAP_Human1.64782772
64ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.64758514
65PCGF2_27294783_Chip-Seq_ESCs_Mouse1.63026288
66RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.60881493
67ELK3_25401928_ChIP-Seq_HUVEC_Human1.56750958
68* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.56681134
69RNF2_27304074_Chip-Seq_NSC_Mouse1.55089226
70DROSHA_22980978_ChIP-Seq_HELA_Human1.54580319
71NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.54099556
72REST_21632747_ChIP-Seq_MESCs_Mouse1.52752371
73SMAD4_21799915_ChIP-Seq_A2780_Human1.52622047
74CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.51935301
75FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.50570717
76DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.50423160
77* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.49885189
78EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48366881
79ATF3_27146783_Chip-Seq_COLON_Human1.47794197
80CTCF_27219007_Chip-Seq_ERYTHROID_Human1.47405988
81FLI1_27457419_Chip-Seq_LIVER_Mouse1.46952140
82DNAJC2_21179169_ChIP-ChIP_NT2_Human1.44287330
83PIAS1_25552417_ChIP-Seq_VCAP_Human1.43639627
84UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.43160120
85* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.42707372
86SMAD3_21741376_ChIP-Seq_EPCs_Human1.42232894
87TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40835054
88RUNX1_27514584_Chip-Seq_MCF-7_Human1.40461810
89SUZ12_27294783_Chip-Seq_NPCs_Mouse1.40252643
90SA1_27219007_Chip-Seq_ERYTHROID_Human1.39726322
91* CREB1_26743006_Chip-Seq_LNCaP_Human1.39306542
92SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36850838
93UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.35031380
94PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33922214
95TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.33612265
96NANOG_18555785_Chip-Seq_ESCs_Mouse1.33508933
97ER_23166858_ChIP-Seq_MCF-7_Human1.33460525
98CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.32474311
99EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.32165209
100TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.31937009
101ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.30620311
102KDM2B_26808549_Chip-Seq_K562_Human1.29501170
103SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28969575
104OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28440272
105MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.28234633
106P63_26484246_Chip-Seq_KERATINOCYTES_Human1.27656506
107SMAD_19615063_ChIP-ChIP_OVARY_Human1.27627088
108BCL6_27268052_Chip-Seq_Bcells_Human1.27013061
109BCOR_27268052_Chip-Seq_Bcells_Human1.26409185
110E2F1_18555785_Chip-Seq_ESCs_Mouse1.24316457
111SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.24042352
112TP63_22573176_ChIP-Seq_HFKS_Human1.23422864
113RARB_24833708_ChIP-Seq_LIVER_Mouse1.23323238
114SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22751383
115NFE2_27457419_Chip-Seq_LIVER_Mouse1.22091213
116MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.21468136
117FUS_26573619_Chip-Seq_HEK293_Human1.21391649
118P53_22387025_ChIP-Seq_ESCs_Mouse1.21156615
119SMC3_22415368_ChIP-Seq_MEFs_Mouse1.21124760
120E2F1_20622854_ChIP-Seq_HELA_Human1.20270037
121SUZ12_18555785_Chip-Seq_ESCs_Mouse1.19399323
122TBX20_22328084_ChIP-Seq_HEART_Mouse1.19329649
123TBX20_22080862_ChIP-Seq_HEART_Mouse1.19329649
124* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.18904056
125TET1_21490601_ChIP-Seq_MESCs_Mouse1.18376717
126CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.18299144
127SA1_27219007_Chip-Seq_Bcells_Human1.17518785
128TP53_18474530_ChIP-ChIP_U2OS_Human1.15975461
129CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15763560
130TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14774674
131EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.14661686
132RAD21_21589869_ChIP-Seq_MESCs_Mouse1.14495517
133ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.13817092
134SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.13720021
135CMYC_18555785_Chip-Seq_ESCs_Mouse1.13716935
136SRY_22984422_ChIP-ChIP_TESTIS_Rat1.13378273
137PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.13069334
138TP53_22127205_ChIP-Seq_IMR90_Human1.12372667
139EZH2_27294783_Chip-Seq_NPCs_Mouse1.12233565
140AR_25329375_ChIP-Seq_VCAP_Human1.11806751
141CTCF_20526341_ChIP-Seq_ESCs_Human1.11554910
142RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.11489156
143ELF1_20517297_ChIP-Seq_JURKAT_Human1.11464229
144STAT3_23295773_ChIP-Seq_U87_Human1.10604948
145STAT3_18555785_Chip-Seq_ESCs_Mouse1.10557059
146P300_18555785_Chip-Seq_ESCs_Mouse1.09885758
147STAT6_21828071_ChIP-Seq_BEAS2B_Human1.09458622
148RING1B_27294783_Chip-Seq_ESCs_Mouse1.09314731
149MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.09239158
150KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09058577
151EP300_21415370_ChIP-Seq_HL-1_Mouse1.08897351
152* FOXP1_21924763_ChIP-Seq_HESCs_Human1.08634829
153CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.07861182
154RARA_24833708_ChIP-Seq_LIVER_Mouse1.07664468
155NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07299581
156CLOCK_20551151_ChIP-Seq_293T_Human1.06984763
157PHF8_20622854_ChIP-Seq_HELA_Human1.06948633
158AHR_22903824_ChIP-Seq_MCF-7_Human1.06741110
159RUNX2_22187159_ChIP-Seq_PCA_Human1.06545135
160REST_18959480_ChIP-ChIP_MESCs_Mouse1.05726235
161TP53_20018659_ChIP-ChIP_R1E_Mouse1.05384737
162TAL1_26923725_Chip-Seq_HPCs_Mouse1.05086511
163TP53_23651856_ChIP-Seq_MEFs_Mouse1.05045281
164NMYC_18555785_Chip-Seq_ESCs_Mouse1.04669691
165TCF4_23295773_ChIP-Seq_U87_Human1.04578782
166POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04349934
167TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04349934
168RUNX1_27457419_Chip-Seq_LIVER_Mouse1.03997275
169LXR_22158963_ChIP-Seq_LIVER_Mouse1.03973673
170MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03852892
171TBX5_21415370_ChIP-Seq_HL-1_Mouse1.03256428
172ARNT_22903824_ChIP-Seq_MCF-7_Human1.02718454
173BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02711716
174* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.02219922
175SOX2_18555785_Chip-Seq_ESCs_Mouse1.02208916
176CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.02020356
177P300_27058665_Chip-Seq_ZR-75-30cells_Human1.01596711
178KDM2B_26808549_Chip-Seq_REH_Human1.01503112
179CTCF_21964334_Chip-Seq_Bcells_Human1.01081182
180NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.01072847
181AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01071568
182IKZF1_21737484_ChIP-ChIP_HCT116_Human1.00662152
183PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.00508549
184TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00206061
185P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99803768
186SRF_21415370_ChIP-Seq_HL-1_Mouse0.99513282
187KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.99161226
188NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98461589
189PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.98331743
190BCAT_22108803_ChIP-Seq_LS180_Human0.97882037
191RING1B_27294783_Chip-Seq_NPCs_Mouse0.96981954
192PRDM14_20953172_ChIP-Seq_ESCs_Human0.96728983
193STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.96580838
194NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.96374783
195SOX2_21211035_ChIP-Seq_LN229_Gbm0.95971343
196NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.95536137
197CTCF_26484167_Chip-Seq_Bcells_Mouse0.94353787
198* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.93699013
199RXRA_24833708_ChIP-Seq_LIVER_Mouse0.93422885

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.72817087
2MP0006276_abnormal_autonomic_nervous2.80147210
3MP0002735_abnormal_chemical_nociception2.79496216
4MP0004270_analgesia2.79238522
5MP0009780_abnormal_chondrocyte_physiolo2.79004080
6MP0002837_dystrophic_cardiac_calcinosis2.72621222
7MP0001968_abnormal_touch/_nociception2.70914251
8MP0003136_yellow_coat_color2.61167823
9MP0000750_abnormal_muscle_regeneration2.60046941
10MP0000751_myopathy2.59366200
11MP0001188_hyperpigmentation2.56971966
12MP0010234_abnormal_vibrissa_follicle2.48816417
13MP0005670_abnormal_white_adipose2.48691894
14MP0005423_abnormal_somatic_nervous2.36155270
15MP0004233_abnormal_muscle_weight2.29212928
16MP0002736_abnormal_nociception_after2.22748724
17MP0001486_abnormal_startle_reflex2.18860832
18MP0002734_abnormal_mechanical_nocicepti2.18795822
19MP0000013_abnormal_adipose_tissue2.17734465
20MP0001986_abnormal_taste_sensitivity2.17291927
21MP0004145_abnormal_muscle_electrophysio2.09224062
22MP0009745_abnormal_behavioral_response2.08773553
23MP0004087_abnormal_muscle_fiber2.08296091
24MP0000003_abnormal_adipose_tissue2.07417341
25MP0003646_muscle_fatigue2.06453717
26MP0005409_darkened_coat_color2.04273628
27MP0002272_abnormal_nervous_system2.03310620
28MP0004859_abnormal_synaptic_plasticity2.02782616
29MP0003635_abnormal_synaptic_transmissio2.01951015
30MP0004130_abnormal_muscle_cell2.01892926
31MP0000749_muscle_degeneration1.99105653
32MP0003123_paternal_imprinting1.98206103
33MP0005083_abnormal_biliary_tract1.97859652
34MP0002572_abnormal_emotion/affect_behav1.77602070
35MP0004742_abnormal_vestibular_system1.76170472
36MP0002064_seizures1.73891727
37MP0009046_muscle_twitch1.72364055
38MP0001970_abnormal_pain_threshold1.72085890
39MP0001905_abnormal_dopamine_level1.71718602
40MP0002269_muscular_atrophy1.71614904
41MP0008875_abnormal_xenobiotic_pharmacok1.71251119
42MP0004215_abnormal_myocardial_fiber1.71196116
43MP0002067_abnormal_sensory_capabilities1.71051877
44MP0002102_abnormal_ear_morphology1.70478494
45MP0005375_adipose_tissue_phenotype1.69056425
46MP0002733_abnormal_thermal_nociception1.64042456
47MP0001440_abnormal_grooming_behavior1.61713958
48MP0002638_abnormal_pupillary_reflex1.61058114
49MP0002063_abnormal_learning/memory/cond1.60564972
50MP0004142_abnormal_muscle_tone1.58297208
51MP0000778_abnormal_nervous_system1.55778754
52MP0003879_abnormal_hair_cell1.53406047
53MP0002184_abnormal_innervation1.53150719
54MP0001529_abnormal_vocalization1.50752923
55MP0003137_abnormal_impulse_conducting1.49591499
56MP0005666_abnormal_adipose_tissue1.48486496
57MP0003705_abnormal_hypodermis_morpholog1.47687429
58MP0005365_abnormal_bile_salt1.47603584
59MP0006292_abnormal_olfactory_placode1.46479972
60MP0010386_abnormal_urinary_bladder1.42898440
61MP0001661_extended_life_span1.40353910
62MP0005645_abnormal_hypothalamus_physiol1.38961265
63MP0005332_abnormal_amino_acid1.38500653
64MP0001501_abnormal_sleep_pattern1.37334905
65MP0009840_abnormal_foam_cell1.37283147
66MP0005058_abnormal_lysosome_morphology1.37262441
67MP0005171_absent_coat_pigmentation1.37259250
68MP0002557_abnormal_social/conspecific_i1.33880120
69MP0006036_abnormal_mitochondrial_physio1.32620597
70MP0002909_abnormal_adrenal_gland1.31513508
71MP0001984_abnormal_olfaction1.30403042
72MP0004381_abnormal_hair_follicle1.29827158
73MP0004043_abnormal_pH_regulation1.29366480
74MP0004484_altered_response_of1.29000950
75MP0000566_synostosis1.28585460
76MP0004036_abnormal_muscle_relaxation1.27773522
77MP0002822_catalepsy1.26783895
78MP0000920_abnormal_myelination1.23051620
79MP0004510_myositis1.20537562
80* MP0005620_abnormal_muscle_contractility1.20362341
81MP0004085_abnormal_heartbeat1.19279746
82MP0000026_abnormal_inner_ear1.16674321
83MP0005551_abnormal_eye_electrophysiolog1.15833065
84MP0003950_abnormal_plasma_membrane1.15396738
85MP0002752_abnormal_somatic_nervous1.14264073
86MP0005386_behavior/neurological_phenoty1.12092437
87MP0004924_abnormal_behavior1.12092437
88MP0001756_abnormal_urination1.11982676
89MP0004185_abnormal_adipocyte_glucose1.11563228
90MP0002882_abnormal_neuron_morphology1.10480002
91MP0001485_abnormal_pinna_reflex1.07261021
92MP0002108_abnormal_muscle_morphology1.06841090
93MP0005257_abnormal_intraocular_pressure1.06172108
94MP0001963_abnormal_hearing_physiology1.06165185
95MP0001502_abnormal_circadian_rhythm1.05987156
96MP0005646_abnormal_pituitary_gland1.05630984
97MP0002106_abnormal_muscle_physiology1.05137105
98MP0000678_abnormal_parathyroid_gland1.04757318
99MP0010030_abnormal_orbit_morphology1.04618871
100MP0005360_urolithiasis1.03320120
101MP0002971_abnormal_brown_adipose1.02806647
102MP0002751_abnormal_autonomic_nervous1.02435467
103MP0009250_abnormal_appendicular_skeleto1.02275510
104* MP0002972_abnormal_cardiac_muscle1.02095350
105MP0006072_abnormal_retinal_apoptosis1.00924004
106MP0010329_abnormal_lipoprotein_level1.00586438
107MP0002277_abnormal_respiratory_mucosa0.99405664
108MP0000733_abnormal_muscle_development0.98791861
109MP0005369_muscle_phenotype0.98614159
110MP0008569_lethality_at_weaning0.98391884
111MP0006138_congestive_heart_failure0.98260807
112MP0000955_abnormal_spinal_cord0.97751144
113MP0003938_abnormal_ear_development0.97692780
114MP0005379_endocrine/exocrine_gland_phen0.97358918
115MP0002066_abnormal_motor_capabilities/c0.97324956
116MP0003011_delayed_dark_adaptation0.93164100
117MP0000762_abnormal_tongue_morphology0.92839959
118MP0003787_abnormal_imprinting0.91767531
119MP0005330_cardiomyopathy0.91224150
120MP0004858_abnormal_nervous_system0.90481502
121MP0000759_abnormal_skeletal_muscle0.90381503
122MP0002118_abnormal_lipid_homeostasis0.88286121
123MP0004019_abnormal_vitamin_homeostasis0.87865814
124MP0002796_impaired_skin_barrier0.87009011
125MP0002139_abnormal_hepatobiliary_system0.83702192
126MP0000538_abnormal_urinary_bladder0.82985103
127MP0002078_abnormal_glucose_homeostasis0.82885060
128MP0003941_abnormal_skin_development0.82760497
129MP0002229_neurodegeneration0.81821882
130MP0001542_abnormal_bone_strength0.81612439
131MP0005253_abnormal_eye_physiology0.81440384
132MP0004084_abnormal_cardiac_muscle0.81390449
133MP0002877_abnormal_melanocyte_morpholog0.81358244
134MP0008260_abnormal_autophagy0.80455878
135MP0008775_abnormal_heart_ventricle0.80195017
136MP0000372_irregular_coat_pigmentation0.80019418
137MP0004272_abnormal_basement_membrane0.79887940
138MP0000631_abnormal_neuroendocrine_gland0.79537222
139MP0002249_abnormal_larynx_morphology0.79338971
140MP0005266_abnormal_metabolism0.79047970
141MP0010630_abnormal_cardiac_muscle0.78728374
142MP0002876_abnormal_thyroid_physiology0.77473583
143MP0001346_abnormal_lacrimal_gland0.77007885
144MP0005385_cardiovascular_system_phenoty0.76993037
145MP0001544_abnormal_cardiovascular_syste0.76993037
146MP0002089_abnormal_postnatal_growth/wei0.76217086
147MP0003453_abnormal_keratinocyte_physiol0.74098235
148MP0005501_abnormal_skin_physiology0.73700226
149MP0005167_abnormal_blood-brain_barrier0.73534818
150MP0005451_abnormal_body_composition0.73516183
151MP0000747_muscle_weakness0.73227604
152MP0002332_abnormal_exercise_endurance0.72421671
153MP0009643_abnormal_urine_homeostasis0.72166906
154MP0001765_abnormal_ion_homeostasis0.71900962
155MP0000049_abnormal_middle_ear0.71643102
156MP0005623_abnormal_meninges_morphology0.71311496
157MP0001664_abnormal_digestion0.70947817
158MP0002896_abnormal_bone_mineralization0.69428917
159MP0001944_abnormal_pancreas_morphology0.67189148
160MP0005584_abnormal_enzyme/coenzyme_acti0.66309041
161MP0005535_abnormal_body_temperature0.65003994
162MP0000467_abnormal_esophagus_morphology0.64325771
163MP0005448_abnormal_energy_balance0.61908165
164MP0008438_abnormal_cutaneous_collagen0.61588546
165MP0000579_abnormal_nail_morphology0.60892821
166MP0003953_abnormal_hormone_level0.59501865
167MP0001958_emphysema0.59258607

Predicted human phenotypes

RankGene SetZ-score
1Type 1 muscle fiber predominance (HP:0003803)4.34582233
2Exercise-induced muscle cramps (HP:0003710)4.24805076
3Muscle hypertrophy of the lower extremities (HP:0008968)4.09526377
4Myopathic facies (HP:0002058)4.04665196
5Focal motor seizures (HP:0011153)4.04587163
6Calf muscle hypertrophy (HP:0008981)3.88974069
7Myoglobinuria (HP:0002913)3.77884073
8Febrile seizures (HP:0002373)3.66290850
9Rhabdomyolysis (HP:0003201)3.46852792
10Asymmetric septal hypertrophy (HP:0001670)3.26466905
11Testicular atrophy (HP:0000029)3.14694409
12Abnormal ciliary motility (HP:0012262)3.12091627
13Nuclear cataract (HP:0100018)3.10841537
14Sudden death (HP:0001699)3.10065392
15Exercise-induced myalgia (HP:0003738)3.05904900
16Ulnar deviation of the wrist (HP:0003049)3.05554874
17Abnormality of the calf musculature (HP:0001430)3.05109123
18Increased connective tissue (HP:0009025)2.94018671
19Absent/shortened dynein arms (HP:0200106)2.92331256
20Dynein arm defect of respiratory motile cilia (HP:0012255)2.92331256
21Ulnar claw (HP:0001178)2.87192944
22Bundle branch block (HP:0011710)2.82469382
23Acute necrotizing encephalopathy (HP:0006965)2.80309214
24Abnormality of aromatic amino acid family metabolism (HP:0004338)2.78587362
25Vascular calcification (HP:0004934)2.78452593
26Atrial fibrillation (HP:0005110)2.77007430
27Prolonged QT interval (HP:0001657)2.76649523
28Muscle fiber splitting (HP:0003555)2.75719094
29Neck muscle weakness (HP:0000467)2.70661536
30Abnormal atrioventricular conduction (HP:0005150)2.69494451
31Hypothermia (HP:0002045)2.69402803
32Round ear (HP:0100830)2.68732510
33Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.67327321
34Septo-optic dysplasia (HP:0100842)2.65924448
35Mildly elevated creatine phosphokinase (HP:0008180)2.64934086
36Primary atrial arrhythmia (HP:0001692)2.63612276
37Abnormal respiratory motile cilium physiology (HP:0012261)2.61657263
38Abnormality of glycolysis (HP:0004366)2.55705784
39Hyporeflexia of lower limbs (HP:0002600)2.54345949
40Atonic seizures (HP:0010819)2.53363769
41Steppage gait (HP:0003376)2.50884952
42Supraventricular tachycardia (HP:0004755)2.46785881
43Cardiovascular calcification (HP:0011915)2.44113373
44Progressive macrocephaly (HP:0004481)2.43787056
45Heart block (HP:0012722)2.43685401
46Increased muscle lipid content (HP:0009058)2.42433016
47Retinal dysplasia (HP:0007973)2.40991719
48Myokymia (HP:0002411)2.40672435
49Increased intramyocellular lipid droplets (HP:0012240)2.36897417
50Supraventricular arrhythmia (HP:0005115)2.36874894
51J-shaped sella turcica (HP:0002680)2.35987093
52Stridor (HP:0010307)2.33982066
53Focal seizures (HP:0007359)2.33177254
54Muscle fiber inclusion bodies (HP:0100299)2.32907581
55Mitochondrial inheritance (HP:0001427)2.32352459
56Distal arthrogryposis (HP:0005684)2.32218021
57Syncope (HP:0001279)2.31016425
58Epileptic encephalopathy (HP:0200134)2.30667481
59Hepatic necrosis (HP:0002605)2.30072183
60Distal lower limb muscle weakness (HP:0009053)2.29735491
61Absent septum pellucidum (HP:0001331)2.28501089
62Abnormal mitochondria in muscle tissue (HP:0008316)2.27754950
63Optic disc pallor (HP:0000543)2.24980341
64Ventricular tachycardia (HP:0004756)2.24545292
65Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.22775738
66Broad-based gait (HP:0002136)2.21397985
67Abnormal respiratory motile cilium morphology (HP:0005938)2.20822584
68Abnormal respiratory epithelium morphology (HP:0012253)2.20822584
69Fetal akinesia sequence (HP:0001989)2.20175814
70Parakeratosis (HP:0001036)2.19324568
71Generalized tonic-clonic seizures (HP:0002069)2.18283778
72Increased serum pyruvate (HP:0003542)2.18075778
73Popliteal pterygium (HP:0009756)2.18007449
74Abnormal EKG (HP:0003115)2.17294973
75EMG: myopathic abnormalities (HP:0003458)2.16829836
76Bradycardia (HP:0001662)2.16348559
77Degeneration of the lateral corticospinal tracts (HP:0002314)2.16004070
78Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.16004070
79Exercise intolerance (HP:0003546)2.15734084
80Myotonia (HP:0002486)2.14512368
81Hyperventilation (HP:0002883)2.14043637
82Decreased central vision (HP:0007663)2.12208923
83Abnormality of skeletal muscle fiber size (HP:0012084)2.11554772
84Bulbar palsy (HP:0001283)2.10059916
85Limb dystonia (HP:0002451)2.09746093
86Difficulty climbing stairs (HP:0003551)2.08127189
87Ketoacidosis (HP:0001993)2.06560810
88Nemaline bodies (HP:0003798)2.06141948
89Aplasia cutis congenita (HP:0001057)2.05777217
90Cholecystitis (HP:0001082)2.05711896
91Abnormal gallbladder physiology (HP:0012438)2.05711896
92Increased variability in muscle fiber diameter (HP:0003557)2.04710208
93Delayed CNS myelination (HP:0002188)2.04689153
94Abnormality of the septum pellucidum (HP:0007375)2.04586451
95Upper limb muscle weakness (HP:0003484)2.02386921
96Ragged-red muscle fibers (HP:0003200)2.01446723
97Atelectasis (HP:0100750)2.01107453
98Distal lower limb amyotrophy (HP:0008944)1.99959342
99Duplicated collecting system (HP:0000081)1.98709970
100Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.97865224
101Progressive cerebellar ataxia (HP:0002073)1.96320627
102Centrally nucleated skeletal muscle fibers (HP:0003687)1.96180408
103Optic nerve hypoplasia (HP:0000609)1.94231328
104Dilated cardiomyopathy (HP:0001644)1.93933896
105Abnormal hair whorl (HP:0010721)1.90989020
106Pheochromocytoma (HP:0002666)1.89877935
107Congenital malformation of the right heart (HP:0011723)1.89752725
108Double outlet right ventricle (HP:0001719)1.89752725
109Acute encephalopathy (HP:0006846)1.89556465
110Keratoconus (HP:0000563)1.89230872
111Increased corneal curvature (HP:0100692)1.89230872
112Congenital sensorineural hearing impairment (HP:0008527)1.89092093
113Generalized muscle weakness (HP:0003324)1.88458875
114Muscle stiffness (HP:0003552)1.87635366
115Foot dorsiflexor weakness (HP:0009027)1.87380501
116EMG: neuropathic changes (HP:0003445)1.84883103
117Increased hepatocellular lipid droplets (HP:0006565)1.84166781
118Hypoplastic heart (HP:0001961)1.84042526
119Right ventricular cardiomyopathy (HP:0011663)1.83766413
120Gowers sign (HP:0003391)1.83364682
121Fatigable weakness (HP:0003473)1.82546484
122Abnormality of the neuromuscular junction (HP:0003398)1.82546484
123Abnormality of fatty-acid metabolism (HP:0004359)1.82519646
124Renal Fanconi syndrome (HP:0001994)1.81620172
125Atrioventricular block (HP:0001678)1.81576246
126White forelock (HP:0002211)1.81065509
127Upper limb amyotrophy (HP:0009129)1.80698015
128Distal upper limb amyotrophy (HP:0007149)1.80698015
129Ventricular arrhythmia (HP:0004308)1.80577289
130Lipoatrophy (HP:0100578)1.79499473
131Malignant hyperthermia (HP:0002047)1.78542649
132Hyperkalemia (HP:0002153)1.78400123
133Hypoplastic left heart (HP:0004383)1.77574218
134Akinesia (HP:0002304)1.77452005
135Ketosis (HP:0001946)1.76527365
136Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.75571602
137Rimmed vacuoles (HP:0003805)1.75202508
138Congenital stationary night blindness (HP:0007642)1.74939567
139Increased CSF lactate (HP:0002490)1.74530088
140Abnormality of the foot musculature (HP:0001436)1.74503466
141Abnormality of the renal collecting system (HP:0004742)1.74428035
142Zonular cataract (HP:0010920)1.74401439
143Axonal loss (HP:0003447)1.74298717
144Spinal rigidity (HP:0003306)1.74072162
145Hepatocellular necrosis (HP:0001404)1.73800636
146Absent speech (HP:0001344)1.73783079
147Abnormality of the left ventricular outflow tract (HP:0011103)1.73419887
148Subaortic stenosis (HP:0001682)1.73419887
149Neuroendocrine neoplasm (HP:0100634)1.73409120
150Lower limb amyotrophy (HP:0007210)1.72787937
151Sensory axonal neuropathy (HP:0003390)1.72672558
152Oligomenorrhea (HP:0000876)1.71221694
153Hyperphosphatemia (HP:0002905)1.70185885
154Patchy hypopigmentation of hair (HP:0011365)1.69982917
155Abnormality of calcium-phosphate metabolism (HP:0100530)1.69973091
156Absence seizures (HP:0002121)1.69697136
157Nonprogressive disorder (HP:0003680)1.69151594
158Dialeptic seizures (HP:0011146)1.68402540
159Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.68165175
160Achilles tendon contracture (HP:0001771)1.67896282
161Absent phalangeal crease (HP:0006109)1.67566443
162Nasolacrimal duct obstruction (HP:0000579)1.67123628
163Left ventricular hypertrophy (HP:0001712)1.66934566
164Abnormality of the axillary hair (HP:0100134)1.66751647
165Abnormality of the Achilles tendon (HP:0005109)1.64730036
166Acanthosis nigricans (HP:0000956)1.64104513
167Frequent falls (HP:0002359)1.62252819
168Abnormality of polysaccharide metabolism (HP:0011012)1.61864850
169Abnormality of glycosaminoglycan metabolism (HP:0004371)1.61864850
170Abnormality of mucopolysaccharide metabolism (HP:0011020)1.61864850
171Urinary glycosaminoglycan excretion (HP:0003541)1.59747568
172Mucopolysacchariduria (HP:0008155)1.59747568

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.19954074
2TRIB33.69234050
3MAPKAPK33.59023246
4TNIK2.98554757
5EPHA22.85860044
6INSRR2.79058631
7MUSK2.61474373
8PHKG12.45052649
9PHKG22.45052649
10NTRK32.39093039
11SIK12.34364148
12MST1R2.28280455
13OBSCN2.19493583
14MAP2K62.18738583
15MAP2K72.01660401
16TESK12.01150571
17STK391.98533523
18PNCK1.95488531
19MAPK131.95348977
20GRK71.90562760
21EEF2K1.89372234
22PKN21.89093382
23PKN11.87923881
24STK161.77945972
25MARK11.72086919
26NME21.71262030
27PINK11.68137299
28EPHA41.65562873
29ERN11.63644279
30ADRBK21.59778510
31BCKDK1.58368762
32NME11.55743349
33IRAK21.53132327
34PRKD31.50174490
35OXSR11.38212162
36ARAF1.37325541
37MAP3K41.25184772
38GRK51.23467364
39WNK11.21548725
40BMPR1B1.19831117
41MET1.19359818
42WNK41.18066813
43PTK21.17657217
44GRK11.16124787
45PRKCE1.15339257
46ICK1.14898731
47LMTK21.13864051
48BLK1.13492894
49CAMK2A1.13162487
50MAP3K121.12385363
51MOS1.08872240
52NTRK11.08854845
53UHMK11.07307345
54IRAK11.07086205
55NTRK21.05388021
56CAMK2D1.04697323
57PRKD21.04683799
58MKNK21.04122227
59BCR1.00310228
60SIK20.99391970
61ABL20.96686198
62BMPR20.94869523
63MYLK0.93016816
64NEK60.92005334
65ZAK0.91185332
66PIM20.90897832
67PRPF4B0.90424786
68MAP3K60.89943344
69PIK3CA0.89924343
70DMPK0.88857067
71CAMK2B0.88825344
72MAP2K40.88510103
73RPS6KB20.87040844
74MINK10.86577882
75PDK20.85270400
76CDK30.84384870
77RIPK10.83151401
78SGK2230.82958664
79SGK4940.82958664
80MAP3K70.80217153
81DYRK20.79960474
82AKT20.79686927
83FGR0.79647506
84TRPM70.79371619
85TIE10.78616166
86TLK10.78542340
87MAPKAPK50.75523572
88SIK30.75283899
89RPS6KA20.74762662
90CAMK10.73955363
91PDPK10.73422010
92PLK20.72827167
93PRKAA10.71658550
94MTOR0.71279649
95YES10.71081094
96ADRBK10.70929816
97RIPK40.70532290
98IRAK40.70027222
99CAMK1G0.69915395
100ILK0.69673407
101MAP3K30.69310849
102EIF2AK20.69046444
103MAP3K90.68951493
104CAMK2G0.68655506
105PRKD10.67797016
106PRKACA0.66937876
107ROCK20.66893925
108FRK0.66587612
109PAK30.66262594
110MAPK110.65489024
111PRKCI0.65016398
112MAP2K10.64873282
113CDK50.64529592
114FES0.63921476
115EPHB20.63263234
116PRKCG0.62662109
117DAPK20.61874933
118IRAK30.61488386
119PAK60.61375351
120PRKG10.60656312
121CDK80.57111340
122MAP2K30.56109288
123PTK60.55229317
124ROCK10.54635937
125MARK20.54385049
126AKT30.54294393
127LATS20.54128364
128TTN0.53625531
129MAPK120.53080980
130MAPK150.53019500
131MAP3K110.52515311
132SGK20.52495393
133TNK20.52471705
134DYRK1A0.52060864
135CCNB10.51654941
136SGK10.51544165
137CDC42BPA0.50556301
138STK240.49117562
139CLK10.48586649
140PIK3CG0.47430454
141PRKAA20.45878397
142FER0.45212905
143VRK20.42385595
144CDK190.40965785
145TAOK20.40407095
146LIMK10.39564813
147STK380.39395361
148HIPK20.38952676
149STK38L0.37361208
150CSNK1G20.37102641
151CSNK1G30.36286186
152BRAF0.36105437
153PRKACB0.34630728
154PAK40.32031531
155SMG10.31872789
156MAPK40.31028464
157MAP2K20.30510611
158TBK10.29711692
159RPS6KC10.28191849
160RPS6KL10.28191849

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.29687199
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.17199461
3Nicotine addiction_Homo sapiens_hsa050333.17068462
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.98378158
5Fructose and mannose metabolism_Homo sapiens_hsa000512.92920820
6Cardiac muscle contraction_Homo sapiens_hsa042602.79408802
7Parkinsons disease_Homo sapiens_hsa050122.65133542
8Phenylalanine metabolism_Homo sapiens_hsa003602.45907154
9Alzheimers disease_Homo sapiens_hsa050102.38287821
10Sulfur relay system_Homo sapiens_hsa041222.33287593
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.27627500
12Phototransduction_Homo sapiens_hsa047442.20862703
13Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.16624631
14Taste transduction_Homo sapiens_hsa047422.16549969
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.16128869
16Serotonergic synapse_Homo sapiens_hsa047262.11835627
17Arginine biosynthesis_Homo sapiens_hsa002202.11437178
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.08228163
19Morphine addiction_Homo sapiens_hsa050321.98174058
20Glutamatergic synapse_Homo sapiens_hsa047241.96010070
21Huntingtons disease_Homo sapiens_hsa050161.83816231
22Biosynthesis of amino acids_Homo sapiens_hsa012301.83070096
23Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.74980132
24Dilated cardiomyopathy_Homo sapiens_hsa054141.74929488
25Pyruvate metabolism_Homo sapiens_hsa006201.73499336
26GABAergic synapse_Homo sapiens_hsa047271.73496654
27Circadian entrainment_Homo sapiens_hsa047131.70664303
28Olfactory transduction_Homo sapiens_hsa047401.67046916
29Fatty acid elongation_Homo sapiens_hsa000621.66565167
30Calcium signaling pathway_Homo sapiens_hsa040201.65562815
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.65232383
32Carbon metabolism_Homo sapiens_hsa012001.62790932
33Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.58072067
34Cyanoamino acid metabolism_Homo sapiens_hsa004601.56675523
35Axon guidance_Homo sapiens_hsa043601.55256355
36Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.52656907
37Tyrosine metabolism_Homo sapiens_hsa003501.52618014
38Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.50974733
39Synaptic vesicle cycle_Homo sapiens_hsa047211.49042064
40Salivary secretion_Homo sapiens_hsa049701.43997839
41Insulin secretion_Homo sapiens_hsa049111.43856333
42Fatty acid degradation_Homo sapiens_hsa000711.41219097
43Galactose metabolism_Homo sapiens_hsa000521.40038565
44Renin secretion_Homo sapiens_hsa049241.37651293
45Ether lipid metabolism_Homo sapiens_hsa005651.37230171
46Cholinergic synapse_Homo sapiens_hsa047251.36463681
47Glycosaminoglycan degradation_Homo sapiens_hsa005311.35982508
48Collecting duct acid secretion_Homo sapiens_hsa049661.35778562
49beta-Alanine metabolism_Homo sapiens_hsa004101.33289238
50Amphetamine addiction_Homo sapiens_hsa050311.31776691
51Histidine metabolism_Homo sapiens_hsa003401.30426727
52Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.29924485
53Long-term depression_Homo sapiens_hsa047301.29551412
54Glucagon signaling pathway_Homo sapiens_hsa049221.28733077
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.28543278
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.27014569
57Cocaine addiction_Homo sapiens_hsa050301.26821612
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.26075590
59Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.25471968
60Dopaminergic synapse_Homo sapiens_hsa047281.25155320
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.24733854
62Sphingolipid metabolism_Homo sapiens_hsa006001.23883031
63Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.22403932
64PPAR signaling pathway_Homo sapiens_hsa033201.21503869
65Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.20180114
66Oxytocin signaling pathway_Homo sapiens_hsa049211.19899342
67Vitamin B6 metabolism_Homo sapiens_hsa007501.18937827
68Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.18060238
69Sulfur metabolism_Homo sapiens_hsa009201.15037307
70Pentose phosphate pathway_Homo sapiens_hsa000301.14227553
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.13972287
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.13318502
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.11725226
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.10956574
75Fatty acid metabolism_Homo sapiens_hsa012121.09600818
76Vascular smooth muscle contraction_Homo sapiens_hsa042701.07481478
77Gastric acid secretion_Homo sapiens_hsa049711.05969784
78AMPK signaling pathway_Homo sapiens_hsa041521.05466600
79Insulin resistance_Homo sapiens_hsa049311.04806002
80Butanoate metabolism_Homo sapiens_hsa006501.04582409
81Tryptophan metabolism_Homo sapiens_hsa003801.02283003
82cAMP signaling pathway_Homo sapiens_hsa040241.01891694
83Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.97941418
84Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.96272009
85Insulin signaling pathway_Homo sapiens_hsa049100.95887018
86Starch and sucrose metabolism_Homo sapiens_hsa005000.94785067
87Arachidonic acid metabolism_Homo sapiens_hsa005900.93595050
88Long-term potentiation_Homo sapiens_hsa047200.93233068
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.91710226
90cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90833506
91Bile secretion_Homo sapiens_hsa049760.90550149
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.89171427
93Linoleic acid metabolism_Homo sapiens_hsa005910.87834150
94Nitrogen metabolism_Homo sapiens_hsa009100.87197132
95GnRH signaling pathway_Homo sapiens_hsa049120.87095646
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.86012482
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.85088689
98Aldosterone synthesis and secretion_Homo sapiens_hsa049250.84087706
99Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83100497
100Rheumatoid arthritis_Homo sapiens_hsa053230.81576707
101Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.81357149
102Other glycan degradation_Homo sapiens_hsa005110.79868015
103Peroxisome_Homo sapiens_hsa041460.79135809
104Ras signaling pathway_Homo sapiens_hsa040140.78789464
105Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.78501769
106Ovarian steroidogenesis_Homo sapiens_hsa049130.78025382
107Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77479481
108Melanogenesis_Homo sapiens_hsa049160.77412387
109Autoimmune thyroid disease_Homo sapiens_hsa053200.77211599
110alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.75376902
111Gap junction_Homo sapiens_hsa045400.74982641
112Folate biosynthesis_Homo sapiens_hsa007900.72943573
113Dorso-ventral axis formation_Homo sapiens_hsa043200.72088584
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71972310
115Lysine degradation_Homo sapiens_hsa003100.71511020
116Pancreatic secretion_Homo sapiens_hsa049720.70873052
117Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.69868181
118Chemical carcinogenesis_Homo sapiens_hsa052040.66804144
119Complement and coagulation cascades_Homo sapiens_hsa046100.65944918
120Pentose and glucuronate interconversions_Homo sapiens_hsa000400.65615696
121ABC transporters_Homo sapiens_hsa020100.64273067
122Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64062556
123Glutathione metabolism_Homo sapiens_hsa004800.64005025
124Circadian rhythm_Homo sapiens_hsa047100.63938545
125Metabolic pathways_Homo sapiens_hsa011000.63588839
126Vibrio cholerae infection_Homo sapiens_hsa051100.62884033
127MAPK signaling pathway_Homo sapiens_hsa040100.61042826
128ErbB signaling pathway_Homo sapiens_hsa040120.60242475
129Melanoma_Homo sapiens_hsa052180.59954320
130Phospholipase D signaling pathway_Homo sapiens_hsa040720.56791899
131Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.54693314
132Primary bile acid biosynthesis_Homo sapiens_hsa001200.53642950
133Steroid hormone biosynthesis_Homo sapiens_hsa001400.52565935
134Steroid biosynthesis_Homo sapiens_hsa001000.52282001
135Wnt signaling pathway_Homo sapiens_hsa043100.52177582
136Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49607911
137Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48620487
138Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48548138
139Central carbon metabolism in cancer_Homo sapiens_hsa052300.48070350
140Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47735258
141Lysosome_Homo sapiens_hsa041420.47372564
142Hedgehog signaling pathway_Homo sapiens_hsa043400.45845016
143Choline metabolism in cancer_Homo sapiens_hsa052310.45464294
144Phagosome_Homo sapiens_hsa041450.44537997
145Cysteine and methionine metabolism_Homo sapiens_hsa002700.44323831
146mTOR signaling pathway_Homo sapiens_hsa041500.43638121
147Protein export_Homo sapiens_hsa030600.42855688
148Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42706028
149Sphingolipid signaling pathway_Homo sapiens_hsa040710.41072150
150Prion diseases_Homo sapiens_hsa050200.39826628
151Type II diabetes mellitus_Homo sapiens_hsa049300.37937522
152Regulation of autophagy_Homo sapiens_hsa041400.37399751
153African trypanosomiasis_Homo sapiens_hsa051430.35992523
154Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35577919
155Rap1 signaling pathway_Homo sapiens_hsa040150.33968017
156Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.33815179
157Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33730219
158ECM-receptor interaction_Homo sapiens_hsa045120.33069484
159Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32773692
160Arginine and proline metabolism_Homo sapiens_hsa003300.32478985
161Glycerophospholipid metabolism_Homo sapiens_hsa005640.30647426
162Asthma_Homo sapiens_hsa053100.30019387
163Basal cell carcinoma_Homo sapiens_hsa052170.29380742
164Mineral absorption_Homo sapiens_hsa049780.29315829
165Propanoate metabolism_Homo sapiens_hsa006400.29017122
166Graft-versus-host disease_Homo sapiens_hsa053320.28964191
167Tight junction_Homo sapiens_hsa045300.27876282
168Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27833726

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