NOC2L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histone modification by histone acetyltransferases (HAT) and histone deacetylases (HDAC) can control major aspects of transcriptional regulation. NOC2L represents a novel HDAC-independent inhibitor of histone acetyltransferase (INHAT) (Hublitz et al., 2005 [PubMed 16322561]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.45232085
2folic acid-containing compound biosynthetic process (GO:0009396)5.22686532
3proline biosynthetic process (GO:0006561)4.98028307
4COPI coating of Golgi vesicle (GO:0048205)4.81829666
5Golgi transport vesicle coating (GO:0048200)4.81829666
6DNA strand elongation involved in DNA replication (GO:0006271)4.66686158
7nuclear pore organization (GO:0006999)4.65161211
8protein localization to kinetochore (GO:0034501)4.56271206
9IMP biosynthetic process (GO:0006188)4.54963360
10formation of translation preinitiation complex (GO:0001731)4.51737630
11nuclear pore complex assembly (GO:0051292)4.49854046
12nucleobase biosynthetic process (GO:0046112)4.41747766
13DNA strand elongation (GO:0022616)4.39958237
14DNA replication initiation (GO:0006270)4.29830822
15mitotic nuclear envelope disassembly (GO:0007077)4.20775091
16telomere maintenance via semi-conservative replication (GO:0032201)4.18784470
17pre-miRNA processing (GO:0031054)4.16459755
18ribosomal small subunit assembly (GO:0000028)4.06565725
19maturation of SSU-rRNA (GO:0030490)4.06070512
20regulation of translational fidelity (GO:0006450)3.99296968
21IMP metabolic process (GO:0046040)3.97046302
22viral transcription (GO:0019083)3.95092648
23membrane disassembly (GO:0030397)3.91481672
24nuclear envelope disassembly (GO:0051081)3.91481672
25regulation of translational termination (GO:0006449)3.84056322
26DNA duplex unwinding (GO:0032508)3.83614737
27alternative mRNA splicing, via spliceosome (GO:0000380)3.81806845
28DNA geometric change (GO:0032392)3.79836421
29negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.78368629
30protein complex localization (GO:0031503)3.76862708
31DNA replication-dependent nucleosome assembly (GO:0006335)3.75310177
32DNA replication-dependent nucleosome organization (GO:0034723)3.75310177
33translational termination (GO:0006415)3.74423480
34protein localization to chromosome, centromeric region (GO:0071459)3.67752022
35telomere maintenance via recombination (GO:0000722)3.62567481
36purine nucleobase biosynthetic process (GO:0009113)3.57839979
37heterochromatin organization (GO:0070828)3.51674174
38peptidyl-arginine omega-N-methylation (GO:0035247)3.50410388
39translational initiation (GO:0006413)3.49285915
40nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.49180864
41ribosome biogenesis (GO:0042254)3.48824516
42mitotic recombination (GO:0006312)3.48323372
43cellular protein complex localization (GO:0034629)3.48291103
44negative regulation of RNA splicing (GO:0033119)3.47193382
45translational elongation (GO:0006414)3.44521700
46regulation of mammary gland epithelial cell proliferation (GO:0033599)3.43982646
47pore complex assembly (GO:0046931)3.43823362
48ribosome assembly (GO:0042255)3.43517807
49DNA replication checkpoint (GO:0000076)3.38333609
50nucleobase-containing small molecule interconversion (GO:0015949)3.37957661
51nucleotide-excision repair, DNA gap filling (GO:0006297)3.37194132
52retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.34361002
53DNA deamination (GO:0045006)3.32675463
54mitotic chromosome condensation (GO:0007076)3.30821103
55ribonucleoprotein complex biogenesis (GO:0022613)3.30751847
56regulation of histone H3-K9 methylation (GO:0051570)3.27512140
57proline metabolic process (GO:0006560)3.24900970
58regulation of translational elongation (GO:0006448)3.24109292
59mitotic nuclear envelope reassembly (GO:0007084)3.24038582
60nuclear envelope reassembly (GO:0031468)3.24038582
61negative regulation of histone methylation (GO:0031061)3.23881318
62DNA topological change (GO:0006265)3.22851216
63telomere maintenance via telomere lengthening (GO:0010833)3.22463963
64ribosomal large subunit biogenesis (GO:0042273)3.21701154
65ribosomal small subunit biogenesis (GO:0042274)3.21503338
66mitotic sister chromatid segregation (GO:0000070)3.21152711
67establishment of integrated proviral latency (GO:0075713)3.21109186
68dosage compensation (GO:0007549)3.20461802
69negative regulation of mRNA processing (GO:0050686)3.20055811
70rRNA transcription (GO:0009303)3.19030665
71regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.18137799
723-UTR-mediated mRNA stabilization (GO:0070935)3.16739446
73tRNA aminoacylation for protein translation (GO:0006418)3.15949083
74protein-DNA complex disassembly (GO:0032986)3.15866386
75nucleosome disassembly (GO:0006337)3.15866386
76sister chromatid segregation (GO:0000819)3.12601023
77viral mRNA export from host cell nucleus (GO:0046784)3.12461379
78positive regulation of chromosome segregation (GO:0051984)3.12039966
79nuclear envelope organization (GO:0006998)3.11459715
80mitotic metaphase plate congression (GO:0007080)3.11025803
81pentose-phosphate shunt (GO:0006098)3.10363758
82protein export from nucleus (GO:0006611)3.07157860
83translesion synthesis (GO:0019985)3.06546412
84chromosome condensation (GO:0030261)3.06497665
85nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.05925998
86rRNA processing (GO:0006364)3.05742064
87protein maturation by protein folding (GO:0022417)3.04811438
88tRNA aminoacylation (GO:0043039)3.04177110
89amino acid activation (GO:0043038)3.04177110
90regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.02418932
91* chromatin assembly (GO:0031497)3.02177586
92snRNA metabolic process (GO:0016073)3.00817800
93L-serine metabolic process (GO:0006563)3.00722768
94regulation of spindle organization (GO:0090224)3.00293580
95negative regulation of mRNA metabolic process (GO:1903312)3.00135912
96peptidyl-arginine N-methylation (GO:0035246)2.99297013
97peptidyl-arginine methylation (GO:0018216)2.99297013
98regulation of gene silencing by RNA (GO:0060966)2.99091400
99regulation of posttranscriptional gene silencing (GO:0060147)2.99091400
100regulation of gene silencing by miRNA (GO:0060964)2.99091400
101RNA stabilization (GO:0043489)2.98778967
102mRNA stabilization (GO:0048255)2.98778967
103DNA conformation change (GO:0071103)2.98586646
104RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.97995911
105mRNA splicing, via spliceosome (GO:0000398)2.97995911
106regulation of RNA export from nucleus (GO:0046831)2.97665812
107cellular protein complex disassembly (GO:0043624)2.96499556
108rRNA metabolic process (GO:0016072)2.96086932
109mitotic sister chromatid cohesion (GO:0007064)2.95557598
110RNA splicing, via transesterification reactions (GO:0000375)2.95398488
111folic acid metabolic process (GO:0046655)2.92581670
112SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.91404271
113negative regulation of cell size (GO:0045792)2.90042536
114positive regulation of DNA-dependent DNA replication (GO:2000105)2.89699481
115regulation of podosome assembly (GO:0071801)2.89553523
116tetrahydrofolate metabolic process (GO:0046653)2.88726665
117nuclear-transcribed mRNA catabolic process (GO:0000956)2.88403135
118spliceosomal tri-snRNP complex assembly (GO:0000244)2.88389273
119protein complex disassembly (GO:0043241)2.88335723
120histone arginine methylation (GO:0034969)2.86508214
121viral life cycle (GO:0019058)2.84908553
122maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.84234180
123mitochondrial DNA metabolic process (GO:0032042)2.84155482
124pteridine-containing compound biosynthetic process (GO:0042559)2.83967505
125RNA catabolic process (GO:0006401)2.83891856
126mRNA transport (GO:0051028)2.83822575
127mitotic G1 DNA damage checkpoint (GO:0031571)2.83763715
128tRNA methylation (GO:0030488)2.83491910
129* chromatin assembly or disassembly (GO:0006333)2.83321948
130protein targeting to ER (GO:0045047)2.82152229
131NADPH regeneration (GO:0006740)2.81323206
132activation of Rac GTPase activity (GO:0032863)2.79782382
133mitochondrial fusion (GO:0008053)2.79130113
134protein retention in ER lumen (GO:0006621)2.78344240
135cotranslational protein targeting to membrane (GO:0006613)2.78123382
136pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.77808129
137regulation of mitotic spindle organization (GO:0060236)2.77672191
138pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.73670259
139GDP-mannose metabolic process (GO:0019673)2.71355351
140snRNA processing (GO:0016180)2.70808662
141glucose catabolic process (GO:0006007)2.69069036
142pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.65980475
143DNA synthesis involved in DNA repair (GO:0000731)2.65915853
144apoptotic process involved in morphogenesis (GO:0060561)2.64437293
145DNA packaging (GO:0006323)2.62894881
146mitochondrial RNA metabolic process (GO:0000959)2.62509000

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.14351248
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.05188678
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.02190092
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.74035663
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.41546470
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.28699378
7MYC_22102868_ChIP-Seq_BL_Human3.01192119
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.92089122
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.58322915
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.46102766
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.25339710
12* XRN2_22483619_ChIP-Seq_HELA_Human2.16104774
13E2F1_21310950_ChIP-Seq_MCF-7_Human1.99497083
14NELFA_20434984_ChIP-Seq_ESCs_Mouse1.97541188
15AR_21909140_ChIP-Seq_LNCAP_Human1.95257182
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.92778902
17ETS1_20019798_ChIP-Seq_JURKAT_Human1.88203818
18POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.87059460
19VDR_21846776_ChIP-Seq_THP-1_Human1.86994594
20TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.85074849
21CIITA_25753668_ChIP-Seq_RAJI_Human1.79256379
22TP63_17297297_ChIP-ChIP_HaCaT_Human1.73988030
23ESR1_15608294_ChIP-ChIP_MCF-7_Human1.72934042
24KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.72888911
25EST1_17652178_ChIP-ChIP_JURKAT_Human1.71474844
26CREB1_15753290_ChIP-ChIP_HEK293T_Human1.67020362
27LXR_22292898_ChIP-Seq_THP-1_Human1.66624626
28MYCN_18555785_ChIP-Seq_MESCs_Mouse1.65704641
29TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.63124228
30PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.60809786
31NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.60398495
32VDR_23849224_ChIP-Seq_CD4+_Human1.59268595
33HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.59140072
34* KDM5A_27292631_Chip-Seq_BREAST_Human1.58846658
35SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.58326971
36RACK7_27058665_Chip-Seq_MCF-7_Human1.53801783
37MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.52760748
38STAT3_1855785_ChIP-Seq_MESCs_Mouse1.52287093
39NANOG_18555785_ChIP-Seq_MESCs_Mouse1.51491879
40JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.49384026
41ZFX_18555785_ChIP-Seq_MESCs_Mouse1.48858732
42ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.48407244
43DCP1A_22483619_ChIP-Seq_HELA_Human1.47899293
44FOXP3_21729870_ChIP-Seq_TREG_Human1.47254236
45GABP_17652178_ChIP-ChIP_JURKAT_Human1.42232241
46MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.41642473
47E2F1_18555785_ChIP-Seq_MESCs_Mouse1.40617625
48* TTF2_22483619_ChIP-Seq_HELA_Human1.40126827
49CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.38627333
50* GABP_19822575_ChIP-Seq_HepG2_Human1.35679956
51KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.35404005
52TCF7_22412390_ChIP-Seq_EML_Mouse1.35113532
53HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.34161924
54TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32948045
55SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.30293991
56* MAF_26560356_Chip-Seq_TH1_Human1.30279226
57TET1_21451524_ChIP-Seq_MESCs_Mouse1.30078125
58PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29848237
59NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.29801217
60KLF4_18555785_ChIP-Seq_MESCs_Mouse1.27534062
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.26356382
62* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.25801486
63DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.25492186
64CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.24623285
65* P68_20966046_ChIP-Seq_HELA_Human1.24030317
66SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23710549
67CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.22802341
68YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22385881
69UTX_26944678_Chip-Seq_JUKART_Human1.22185740
70POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.21452760
71KDM2B_26808549_Chip-Seq_DND41_Human1.20666086
72RARG_19884340_ChIP-ChIP_MEFs_Mouse1.18615468
73THAP11_20581084_ChIP-Seq_MESCs_Mouse1.18286692
74SRY_22984422_ChIP-ChIP_TESTIS_Rat1.17006120
75* ELK3_25401928_ChIP-Seq_HUVEC_Human1.16585729
76TFEB_21752829_ChIP-Seq_HELA_Human1.15894687
77KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.15475469
78SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.14199704
79EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14007243
80SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.13738779
81SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.12888073
82TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10838528
83MYB_21317192_ChIP-Seq_ERMYB_Mouse1.08619778
84* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07435179
85PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.06653895
86MYB_26560356_Chip-Seq_TH1_Human1.06631703
87CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.06401370
88SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.06202044
89ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.05765317
90UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.03691364
91TBX5_21415370_ChIP-Seq_HL-1_Mouse1.02783343
92KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02703368
93* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.02533290
94SPI1_23547873_ChIP-Seq_NB4_Human1.02505731
95ZNF263_19887448_ChIP-Seq_K562_Human1.01413456
96* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.01202776
97HOXB4_20404135_ChIP-ChIP_EML_Mouse1.00742674
98TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00570604
99ERG_20887958_ChIP-Seq_HPC-7_Mouse1.00155572
100ELF1_20517297_ChIP-Seq_JURKAT_Human0.99149702
101VDR_24763502_ChIP-Seq_THP-1_Human0.99112538
102* SA1_27219007_Chip-Seq_ERYTHROID_Human0.98997582
103CLOCK_20551151_ChIP-Seq_293T_Human0.98599550
104ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.98139829
105MYB_26560356_Chip-Seq_TH2_Human0.98117280
106FOXP1_21924763_ChIP-Seq_HESCs_Human0.97652822
107STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.97599109
108CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97212087
109YY1_21170310_ChIP-Seq_MESCs_Mouse0.96493013
110BRD4_27068464_Chip-Seq_AML-cells_Mouse0.95331003
111RUNX1_22412390_ChIP-Seq_EML_Mouse0.95260377
112FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.94293151
113MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.93777490
114SCL_19346495_ChIP-Seq_HPC-7_Human0.93449406
115ELK1_19687146_ChIP-ChIP_HELA_Human0.93325546
116ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.93292490
117FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.92734117
118* MAF_26560356_Chip-Seq_TH2_Human0.92609746
119ELF1_17652178_ChIP-ChIP_JURKAT_Human0.92565456
120CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.92340560
121CHD1_26751641_Chip-Seq_LNCaP_Human0.92039568
122ATF3_27146783_Chip-Seq_COLON_Human0.90589101
123GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.90558174
124TP63_19390658_ChIP-ChIP_HaCaT_Human0.88927004
125KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.87967961
126* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.87173975
127BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.84772346
128NCOR1_26117541_ChIP-Seq_K562_Human0.84523286

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.77342542
2MP0004957_abnormal_blastocyst_morpholog4.39766333
3MP0010094_abnormal_chromosome_stability3.98743711
4MP0003111_abnormal_nucleus_morphology3.92927493
5MP0008057_abnormal_DNA_replication3.50615630
6MP0003077_abnormal_cell_cycle3.36814584
7MP0008007_abnormal_cellular_replicative3.17965933
8MP0002396_abnormal_hematopoietic_system3.12151702
9MP0010352_gastrointestinal_tract_polyps3.11992779
10MP0005451_abnormal_body_composition2.95716221
11MP0004233_abnormal_muscle_weight2.50977171
12MP0001730_embryonic_growth_arrest2.48850526
13MP0000350_abnormal_cell_proliferation2.40540090
14MP0010307_abnormal_tumor_latency2.40539687
15MP0004808_abnormal_hematopoietic_stem2.15047915
16MP0003123_paternal_imprinting2.09607669
17MP0008058_abnormal_DNA_repair2.05754381
18MP0003705_abnormal_hypodermis_morpholog1.95765627
19MP0000678_abnormal_parathyroid_gland1.95482518
20MP0005076_abnormal_cell_differentiation1.95442326
21MP0001661_extended_life_span1.92787346
22MP0001672_abnormal_embryogenesis/_devel1.86624288
23MP0005380_embryogenesis_phenotype1.86624288
24MP0008932_abnormal_embryonic_tissue1.86544155
25MP0000490_abnormal_crypts_of1.85221088
26MP0001697_abnormal_embryo_size1.81710057
27MP0003984_embryonic_growth_retardation1.81499576
28MP0002086_abnormal_extraembryonic_tissu1.79860429
29MP0003763_abnormal_thymus_physiology1.79091321
30MP0002088_abnormal_embryonic_growth/wei1.78595184
31MP0002080_prenatal_lethality1.76675172
32MP0001545_abnormal_hematopoietic_system1.74581154
33MP0005397_hematopoietic_system_phenotyp1.74581154
34MP0005501_abnormal_skin_physiology1.73246995
35MP0002398_abnormal_bone_marrow1.62317034
36MP0002084_abnormal_developmental_patter1.61793690
37MP0004197_abnormal_fetal_growth/weight/1.60342313
38MP0002796_impaired_skin_barrier1.59119070
39MP0003303_peritoneal_inflammation1.58197018
40MP0000703_abnormal_thymus_morphology1.57704154
41MP0004858_abnormal_nervous_system1.56803953
42MP0002085_abnormal_embryonic_tissue1.55459584
43MP0009278_abnormal_bone_marrow1.54037297
44MP0009333_abnormal_splenocyte_physiolog1.53182815
45MP0009672_abnormal_birth_weight1.53073348
46MP0002019_abnormal_tumor_incidence1.46842034
47MP0001348_abnormal_lacrimal_gland1.44232114
48MP0002722_abnormal_immune_system1.43086367
49MP0000313_abnormal_cell_death1.40310446
50MP0003786_premature_aging1.40096457
51MP0003566_abnormal_cell_adhesion1.38362720
52MP0000689_abnormal_spleen_morphology1.36210900
53MP0003300_gastrointestinal_ulcer1.27226536
54MP0003453_abnormal_keratinocyte_physiol1.26587100
55MP0008260_abnormal_autophagy1.24635860
56MP0000003_abnormal_adipose_tissue1.23658404
57MP0002429_abnormal_blood_cell1.23488764
58MP0008438_abnormal_cutaneous_collagen1.22147035
59MP0005623_abnormal_meninges_morphology1.21789141
60MP0000685_abnormal_immune_system1.19669601
61MP0005058_abnormal_lysosome_morphology1.19538302
62MP0003567_abnormal_fetal_cardiomyocyte1.19004363
63MP0005023_abnormal_wound_healing1.18103703
64MP0002060_abnormal_skin_morphology1.15971880
65MP0001800_abnormal_humoral_immune1.15780075
66MP0003315_abnormal_perineum_morphology1.14868682
67MP0008877_abnormal_DNA_methylation1.14674228
68MP0000716_abnormal_immune_system1.14493977
69MP0006035_abnormal_mitochondrial_morpho1.13994450
70MP0000747_muscle_weakness1.09460663
71MP0010234_abnormal_vibrissa_follicle1.08290711
72MP0002249_abnormal_larynx_morphology1.07812156
73MP0005666_abnormal_adipose_tissue1.05595802
74MP0003806_abnormal_nucleotide_metabolis1.04686790
75MP0003943_abnormal_hepatobiliary_system1.03196827
76MP0009703_decreased_birth_body1.02319651
77MP0000858_altered_metastatic_potential0.99904465
78MP0002452_abnormal_antigen_presenting0.99792128
79MP0003890_abnormal_embryonic-extraembry0.97908290
80MP0002089_abnormal_postnatal_growth/wei0.96870733
81MP0002420_abnormal_adaptive_immunity0.96665359
82MP0003385_abnormal_body_wall0.96389283
83MP0009053_abnormal_anal_canal0.95128862
84MP0001819_abnormal_immune_cell0.94785609
85MP0001216_abnormal_epidermal_layer0.93996375
86MP0000579_abnormal_nail_morphology0.93727843
87MP0005174_abnormal_tail_pigmentation0.93714627
88MP0005257_abnormal_intraocular_pressure0.93606301
89MP0003121_genomic_imprinting0.92441497
90MP0001915_intracranial_hemorrhage0.91998933
91MP0005464_abnormal_platelet_physiology0.91978339
92MP0005375_adipose_tissue_phenotype0.91911793
93MP0002723_abnormal_immune_serum0.91863720
94MP0003436_decreased_susceptibility_to0.91182867
95MP0000759_abnormal_skeletal_muscle0.91002550
96MP0002405_respiratory_system_inflammati0.89675667
97MP0001849_ear_inflammation0.89196091
98MP0004272_abnormal_basement_membrane0.89177922
99MP0010030_abnormal_orbit_morphology0.88645336
100MP0010155_abnormal_intestine_physiology0.87578197
101MP0000751_myopathy0.87548783
102MP0000467_abnormal_esophagus_morphology0.87462137
103MP0009697_abnormal_copulation0.85710386
104MP0005330_cardiomyopathy0.85233848
105MP0000477_abnormal_intestine_morphology0.84901218
106MP0000733_abnormal_muscle_development0.84405731
107MP0003221_abnormal_cardiomyocyte_apopto0.83899008
108MP0002877_abnormal_melanocyte_morpholog0.82972184
109MP0005621_abnormal_cell_physiology0.82703203
110MP0002269_muscular_atrophy0.81439449
111MP0000566_synostosis0.81095757
112MP0002075_abnormal_coat/hair_pigmentati0.79645527
113MP0000465_gastrointestinal_hemorrhage0.79457713
114MP0000537_abnormal_urethra_morphology0.79354291
115MP0002697_abnormal_eye_size0.79069373
116MP0003942_abnormal_urinary_system0.78914444
117MP0004782_abnormal_surfactant_physiolog0.78637609
118MP0001835_abnormal_antigen_presentation0.78496819
119MP0000750_abnormal_muscle_regeneration0.77477120
120MP0001346_abnormal_lacrimal_gland0.77425534
121MP0008770_decreased_survivor_rate0.77355638
122MP0006054_spinal_hemorrhage0.77132880
123MP0001727_abnormal_embryo_implantation0.76851087
124MP0001293_anophthalmia0.76020390
125MP0004087_abnormal_muscle_fiber0.75769023
126MP0001853_heart_inflammation0.75737815
127MP0005387_immune_system_phenotype0.75255073
128MP0001790_abnormal_immune_system0.75255073
129MP0005384_cellular_phenotype0.75050407
130MP0010630_abnormal_cardiac_muscle0.74456208
131MP0009931_abnormal_skin_appearance0.74012862
132MP0002166_altered_tumor_susceptibility0.72766749
133MP0003866_abnormal_defecation0.72542315
134MP0002970_abnormal_white_adipose0.72269668
135MP0002111_abnormal_tail_morphology0.71758451
136MP0004264_abnormal_extraembryonic_tissu0.71583543
137MP0005171_absent_coat_pigmentation0.70730081
138MP0009840_abnormal_foam_cell0.70424313
139MP0000371_diluted_coat_color0.70149811
140MP0000377_abnormal_hair_follicle0.69663336
141MP0004185_abnormal_adipocyte_glucose0.69604835
142MP0000598_abnormal_liver_morphology0.68106226
143MP0005025_abnormal_response_to0.67941458
144MP0005000_abnormal_immune_tolerance0.67796226
145MP0001873_stomach_inflammation0.67092441
146MP0000358_abnormal_cell_content/0.66505728

Predicted human phenotypes

RankGene SetZ-score
1Neoplasm of the adrenal cortex (HP:0100641)5.94412388
2Diastasis recti (HP:0001540)5.31319239
3Hepatoblastoma (HP:0002884)5.07942187
4Long foot (HP:0001833)4.62814273
5Abnormal pancreas size (HP:0012094)4.35579486
6Neonatal hypoglycemia (HP:0001998)4.28065271
7High anterior hairline (HP:0009890)4.11145185
8Cholecystitis (HP:0001082)3.68097629
9Abnormal gallbladder physiology (HP:0012438)3.68097629
10Reticulocytopenia (HP:0001896)3.58424435
11Progressive muscle weakness (HP:0003323)3.34333342
12Acute myeloid leukemia (HP:0004808)3.34266101
13Insomnia (HP:0100785)3.20900184
14Ependymoma (HP:0002888)3.20057391
15Deep philtrum (HP:0002002)3.18261465
16Birth length less than 3rd percentile (HP:0003561)3.00836458
17Abnormality of cells of the erythroid lineage (HP:0012130)3.00218911
18Ragged-red muscle fibers (HP:0003200)2.98690056
19Microvesicular hepatic steatosis (HP:0001414)2.96001545
20Achilles tendon contracture (HP:0001771)2.92907501
21Partial agenesis of the corpus callosum (HP:0001338)2.85519352
22Abnormal number of erythroid precursors (HP:0012131)2.82635634
23Thrombocytosis (HP:0001894)2.74836493
24Distal lower limb amyotrophy (HP:0008944)2.68907413
25Carpal bone hypoplasia (HP:0001498)2.68378992
26Basal cell carcinoma (HP:0002671)2.68021345
27Selective tooth agenesis (HP:0001592)2.67486183
28Rhabdomyosarcoma (HP:0002859)2.64338380
29Germ cell neoplasia (HP:0100728)2.64106800
30Reticulocytosis (HP:0001923)2.63523389
31Broad distal phalanx of finger (HP:0009836)2.58368017
32Abnormality of glycolysis (HP:0004366)2.56178549
33Premature rupture of membranes (HP:0001788)2.54904601
34Dysmetric saccades (HP:0000641)2.54493107
35Long palpebral fissure (HP:0000637)2.53443468
3611 pairs of ribs (HP:0000878)2.51091628
37Colon cancer (HP:0003003)2.50213592
38Abnormality of the Achilles tendon (HP:0005109)2.49788372
39Progressive external ophthalmoplegia (HP:0000590)2.48353399
40Nephroblastoma (Wilms tumor) (HP:0002667)2.47490876
41Neoplasm of the adrenal gland (HP:0100631)2.45079969
42Truncus arteriosus (HP:0001660)2.44548497
43Increased connective tissue (HP:0009025)2.38298111
44Spinal muscular atrophy (HP:0007269)2.38065171
45Medulloblastoma (HP:0002885)2.36051843
46Sandal gap (HP:0001852)2.35504758
47Large hands (HP:0001176)2.31370078
48Overgrowth (HP:0001548)2.31091473
49Missing ribs (HP:0000921)2.29833022
50Agnosia (HP:0010524)2.28310203
51Centrally nucleated skeletal muscle fibers (HP:0003687)2.27783660
52Ankyloglossia (HP:0010296)2.26354946
53Embryonal renal neoplasm (HP:0011794)2.25314529
54Hand muscle atrophy (HP:0009130)2.24957619
55Sparse lateral eyebrow (HP:0005338)2.22730878
56Chromsome breakage (HP:0040012)2.22422249
57Abnormality of the umbilical cord (HP:0010881)2.21000385
58Overriding aorta (HP:0002623)2.20550790
59Disproportionate tall stature (HP:0001519)2.19640224
60Premature skin wrinkling (HP:0100678)2.18839190
61Neoplasm of striated muscle (HP:0009728)2.16787310
62Breast hypoplasia (HP:0003187)2.15729900
63Deviation of the thumb (HP:0009603)2.15170727
64Myopathic facies (HP:0002058)2.15151362
65Rough bone trabeculation (HP:0100670)2.14793424
66Pointed chin (HP:0000307)2.13644365
67Myelodysplasia (HP:0002863)2.13614863
68Increased density of long bones (HP:0006392)2.13432720
69Astrocytoma (HP:0009592)2.11304930
70Abnormality of the astrocytes (HP:0100707)2.11304930
71Pallor (HP:0000980)2.11057598
72Absent thumb (HP:0009777)2.10964817
73Orthostatic hypotension (HP:0001278)2.08963414
74Patellar dislocation (HP:0002999)2.07221537
75Elfin facies (HP:0004428)2.06416371
76Proximal placement of thumb (HP:0009623)2.05623633
77Abnormality of reticulocytes (HP:0004312)2.05423142
78Hyperacusis (HP:0010780)2.05173925
79Cholelithiasis (HP:0001081)2.04811428
80Chromosomal breakage induced by crosslinking agents (HP:0003221)2.04714236
81Prominent nose (HP:0000448)2.04532001
82High pitched voice (HP:0001620)2.04115373
83Squamous cell carcinoma (HP:0002860)2.03990156
84Abnormality of oral frenula (HP:0000190)2.03291800
85Septate vagina (HP:0001153)2.03122059
86Degeneration of anterior horn cells (HP:0002398)2.01453987
87Abnormality of the anterior horn cell (HP:0006802)2.01453987
88Oral leukoplakia (HP:0002745)1.96929661
89Upper limb muscle weakness (HP:0003484)1.96537166
90Testicular atrophy (HP:0000029)1.95943254
91Renal duplication (HP:0000075)1.95360899
92Abnormality of the fingertips (HP:0001211)1.94558130
93Aplastic anemia (HP:0001915)1.94156853
94Cutaneous melanoma (HP:0012056)1.93071939
95Upper limb amyotrophy (HP:0009129)1.92014481
96Distal upper limb amyotrophy (HP:0007149)1.92014481
97Vertebral compression fractures (HP:0002953)1.91573828
98Macrocytic anemia (HP:0001972)1.91429424
99Hypoplasia of the capital femoral epiphysis (HP:0003090)1.90724373
100Abnormality of the calcaneus (HP:0008364)1.89847423
101Patellar aplasia (HP:0006443)1.89844318
102Nonimmune hydrops fetalis (HP:0001790)1.89450055
103Narrow palate (HP:0000189)1.88935643
104Short nail (HP:0001799)1.88925535
105Genu varum (HP:0002970)1.88695692
106Abnormality of the distal phalanges of the toes (HP:0010182)1.88668617
107Abnormality of the tricuspid valve (HP:0001702)1.88139779
108Amaurosis fugax (HP:0100576)1.87568780
109Lower limb amyotrophy (HP:0007210)1.87117496
110IgM deficiency (HP:0002850)1.87035692
111Elbow flexion contracture (HP:0002987)1.86120111
112Abnormal glucose tolerance (HP:0001952)1.84783304
113Broad face (HP:0000283)1.84478985
114Multiple enchondromatosis (HP:0005701)1.83929078
115Increased nuchal translucency (HP:0010880)1.82408629
116Asymmetry of the thorax (HP:0001555)1.82328728
117Hyperthyroidism (HP:0000836)1.81474663
118Back pain (HP:0003418)1.81384250
119Poikiloderma (HP:0001029)1.81207158
120Abnormality of the gallbladder (HP:0005264)1.81012925
121Trismus (HP:0000211)1.80906303
122Premature ovarian failure (HP:0008209)1.80522738
123Difficulty climbing stairs (HP:0003551)1.79391474
124Increased serum pyruvate (HP:0003542)1.78363891
125Hypoplastic toenails (HP:0001800)1.78162999
126Abnormality of the labia minora (HP:0012880)1.77909527
127Skin tags (HP:0010609)1.77775997
128Progressive hearing impairment (HP:0001730)1.77230889
129Aplasia/Hypoplasia of the patella (HP:0006498)1.76593000
130Unilateral renal agenesis (HP:0000122)1.76086330
131Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.75339370
132Stridor (HP:0010307)1.73981408
133Abnormal large intestine physiology (HP:0012700)1.73977570
134Bowel incontinence (HP:0002607)1.73472930
135Limb-girdle muscle atrophy (HP:0003797)1.71966012
136Glioma (HP:0009733)1.70704534
137Recurrent viral infections (HP:0004429)1.69866541
138Hypertensive crisis (HP:0100735)1.69667221
139Cafe-au-lait spot (HP:0000957)1.69460843
140Aplasia/Hypoplasia of the sacrum (HP:0008517)1.68999388
141Flat cornea (HP:0007720)1.68804321
142Abnormal gallbladder morphology (HP:0012437)1.68763138
143Distal lower limb muscle weakness (HP:0009053)1.68326954
144Preauricular skin tag (HP:0000384)1.67681421
145Neoplasm of the oral cavity (HP:0100649)1.67454820
146Abnormality of chromosome stability (HP:0003220)1.67444997
147Abnormal number of incisors (HP:0011064)1.67414240
148Single umbilical artery (HP:0001195)1.67237847
149Abnormality of the fetal cardiovascular system (HP:0010948)1.67237847
150Abnormal umbilical cord blood vessels (HP:0011403)1.67237847
151Spastic diplegia (HP:0001264)1.66964732
152Hypoparathyroidism (HP:0000829)1.66393400
153Self-mutilation (HP:0000742)1.66250173
154Abnormality of cochlea (HP:0000375)1.65972258
155Aplasia/Hypoplasia of the sternum (HP:0006714)1.65834096
156Overlapping toe (HP:0001845)1.65534492
157Asymmetric growth (HP:0100555)1.64698683
158Advanced eruption of teeth (HP:0006288)1.64406622
159Generalized amyotrophy (HP:0003700)1.64376375
160Spinal rigidity (HP:0003306)1.64231490
161Abnormality of pyrimidine metabolism (HP:0004353)1.64118051
162Insidious onset (HP:0003587)1.63697208
163Termporal pattern (HP:0011008)1.63697208
164Abnormalities of placenta or umbilical cord (HP:0001194)1.63245487
165Flat acetabular roof (HP:0003180)1.63112687
166Ulnar bowing (HP:0003031)1.62935748
167Entropion (HP:0000621)1.62859713
168Lymphoma (HP:0002665)1.61234702
169Urethral obstruction (HP:0000796)1.60650968
170Adenoma sebaceum (HP:0009720)1.60234444
171Angiofibromas (HP:0010615)1.60234444

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG13.99410847
2EEF2K3.98257663
3CDC73.87025391
4IRAK33.17535768
5WEE13.14832249
6CDK122.91602657
7PKN22.85832176
8STK162.77326895
9TSSK62.58595291
10NEK22.55174051
11MKNK22.42731584
12TRIB32.37228967
13MAP3K102.31955486
14MAP4K12.28972592
15PRKG22.18304683
16ALK2.08423318
17MKNK12.01741483
18RPS6KB21.97527371
19MST1R1.94715333
20BUB11.82232454
21STK101.81610883
22CDK41.76694614
23RIPK11.71475946
24PASK1.68380858
25PBK1.66274754
26BRSK21.65512780
27NEK11.65153321
28PRPF4B1.65038163
29TTK1.56560604
30NME21.53929697
31MAP3K81.43926386
32SCYL21.41313390
33CDK71.37196668
34PAK41.34446123
35ATR1.29935210
36LRRK21.27640123
37MAP2K31.22421724
38VRK21.20011776
39SIK21.19136012
40JAK31.17182691
41CHEK11.15038016
42GRK61.14128951
43EIF2AK11.13233464
44AURKB1.11204931
45PLK11.10987001
46RPS6KA41.08882727
47FLT31.08208494
48SRPK11.06435121
49PRKD31.05530267
50LATS21.04201362
51TGFBR10.98562040
52ZAP700.95259384
53PIM10.95199235
54CDK60.94227391
55BRD40.91438640
56BRSK10.91272024
57BRAF0.91193863
58ARAF0.89575378
59KSR20.89487951
60MET0.87331886
61EPHA20.82404133
62MTOR0.82134678
63BTK0.81471996
64CDK20.81024024
65TTN0.78536190
66MAP3K30.77131501
67PTK20.77081804
68ATM0.75465162
69PTK60.75192801
70CHEK20.74712777
71PLK30.72997163
72TESK20.72725683
73LMTK20.71236479
74NME10.70547119
75PDGFRA0.68299111
76CAMK1D0.66324499
77STK40.64071995
78MAP3K110.63074378
79CDK90.62910509
80PAK20.62787190
81DAPK10.61588108
82IRAK20.61210731
83TESK10.60127517
84PIM20.59559949
85TLK10.58192759
86ACVR1B0.57629512
87TAOK10.57434571
88CDK80.55920357
89AURKA0.55310816
90NTRK10.53947089
91CSNK1E0.53379723
92KDR0.53082459
93CLK10.52174052
94PRKCI0.51374341
95CSNK2A20.51206947
96CDK10.50478184
97CSF1R0.49960846
98HIPK20.49764499
99DYRK30.48039896
100EIF2AK30.44615093
101BMX0.43233248
102FGFR40.42494101
103CDK11A0.41448240
104STK30.41277511
105ERBB40.40489849
106MAP3K90.40034834
107PDK20.40031633
108MAPKAPK30.39940261
109MAPK110.39855160
110CCNB10.39715456
111ILK0.38794534
112AKT20.38113740
113PAK10.38093338
114TYK20.37992223
115PRKDC0.37863533
116MAP2K20.37443509
117RAF10.36377609
118MAPK140.36206554
119CDK150.36201756
120SIK10.35859131
121CHUK0.35633563
122PDPK10.34134601
123MAP3K130.33991218
124TAOK20.33546245
125RPS6KA10.32536505
126HCK0.32409219
127LCK0.32199876
128CDK180.31979069
129ICK0.31858429
130SYK0.31133927
131ITK0.31065692
132ERN10.30742492
133RPS6KA20.29575218

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.86157689
2Mismatch repair_Homo sapiens_hsa034304.08868474
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.39616884
4One carbon pool by folate_Homo sapiens_hsa006703.21928476
5RNA transport_Homo sapiens_hsa030133.13115265
6Spliceosome_Homo sapiens_hsa030403.09565705
7Ribosome_Homo sapiens_hsa030102.61298935
8Base excision repair_Homo sapiens_hsa034102.60256836
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.55588267
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.48351954
11Cell cycle_Homo sapiens_hsa041102.46280126
12Nucleotide excision repair_Homo sapiens_hsa034202.40466164
13mRNA surveillance pathway_Homo sapiens_hsa030151.97932248
14Homologous recombination_Homo sapiens_hsa034401.91817027
15RNA polymerase_Homo sapiens_hsa030201.90531513
16Fructose and mannose metabolism_Homo sapiens_hsa000511.81914826
17RNA degradation_Homo sapiens_hsa030181.72156980
18Pyrimidine metabolism_Homo sapiens_hsa002401.62354441
19Cyanoamino acid metabolism_Homo sapiens_hsa004601.59788064
20Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.59726391
21Vitamin B6 metabolism_Homo sapiens_hsa007501.57025098
22Non-homologous end-joining_Homo sapiens_hsa034501.46085721
23Proteasome_Homo sapiens_hsa030501.42967662
24Lysine degradation_Homo sapiens_hsa003101.41512102
25Viral carcinogenesis_Homo sapiens_hsa052031.37709859
26p53 signaling pathway_Homo sapiens_hsa041151.32375443
27Antigen processing and presentation_Homo sapiens_hsa046121.31561349
28Fanconi anemia pathway_Homo sapiens_hsa034601.26611824
29Herpes simplex infection_Homo sapiens_hsa051681.25888197
30N-Glycan biosynthesis_Homo sapiens_hsa005101.18957238
31Epstein-Barr virus infection_Homo sapiens_hsa051691.18327527
32Galactose metabolism_Homo sapiens_hsa000521.16109589
33Chronic myeloid leukemia_Homo sapiens_hsa052201.10432563
34Pyruvate metabolism_Homo sapiens_hsa006201.08701519
35Thyroid cancer_Homo sapiens_hsa052161.08247327
36Primary immunodeficiency_Homo sapiens_hsa053401.06627067
37Selenocompound metabolism_Homo sapiens_hsa004501.06398503
38Biosynthesis of amino acids_Homo sapiens_hsa012301.05357391
39HTLV-I infection_Homo sapiens_hsa051661.05094998
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00666098
41MicroRNAs in cancer_Homo sapiens_hsa052060.96417860
42Other glycan degradation_Homo sapiens_hsa005110.95755541
43Measles_Homo sapiens_hsa051620.92765958
44Acute myeloid leukemia_Homo sapiens_hsa052210.92197763
45Small cell lung cancer_Homo sapiens_hsa052220.92072523
46Systemic lupus erythematosus_Homo sapiens_hsa053220.89345519
47Pentose phosphate pathway_Homo sapiens_hsa000300.86692413
48B cell receptor signaling pathway_Homo sapiens_hsa046620.86510992
49Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.85689573
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.84249765
51mTOR signaling pathway_Homo sapiens_hsa041500.83989349
52Non-small cell lung cancer_Homo sapiens_hsa052230.81668706
53Transcriptional misregulation in cancer_Homo sapiens_hsa052020.80551794
54Basal transcription factors_Homo sapiens_hsa030220.80089604
55NF-kappa B signaling pathway_Homo sapiens_hsa040640.77951424
56Arginine biosynthesis_Homo sapiens_hsa002200.76943257
57Central carbon metabolism in cancer_Homo sapiens_hsa052300.76874227
58Hepatitis B_Homo sapiens_hsa051610.75540934
59Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75375464
60Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.74027294
61Insulin signaling pathway_Homo sapiens_hsa049100.74022399
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.72704329
63Legionellosis_Homo sapiens_hsa051340.72593744
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.71646600
65Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.70988327
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.70536982
67Apoptosis_Homo sapiens_hsa042100.69962237
68Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.69552094
69Prion diseases_Homo sapiens_hsa050200.68743042
70Glioma_Homo sapiens_hsa052140.67653350
71Oocyte meiosis_Homo sapiens_hsa041140.67252370
72AMPK signaling pathway_Homo sapiens_hsa041520.66833954
73Notch signaling pathway_Homo sapiens_hsa043300.65505009
74Colorectal cancer_Homo sapiens_hsa052100.63808797
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63506311
76Arginine and proline metabolism_Homo sapiens_hsa003300.62999230
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62957033
78Influenza A_Homo sapiens_hsa051640.61976253
79Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60358204
80African trypanosomiasis_Homo sapiens_hsa051430.60270629
81Platelet activation_Homo sapiens_hsa046110.59354924
82Folate biosynthesis_Homo sapiens_hsa007900.59046775
83Purine metabolism_Homo sapiens_hsa002300.57936085
84Leishmaniasis_Homo sapiens_hsa051400.57900949
85T cell receptor signaling pathway_Homo sapiens_hsa046600.57204572
86ErbB signaling pathway_Homo sapiens_hsa040120.56730890
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.55594978
88Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54960101
89HIF-1 signaling pathway_Homo sapiens_hsa040660.54610348
90Bladder cancer_Homo sapiens_hsa052190.53873269
91Alcoholism_Homo sapiens_hsa050340.53402567
92Prostate cancer_Homo sapiens_hsa052150.53256935
93Osteoclast differentiation_Homo sapiens_hsa043800.52963441
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.52520767
95Viral myocarditis_Homo sapiens_hsa054160.52025834
96Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.51467656
97Jak-STAT signaling pathway_Homo sapiens_hsa046300.49232161
982-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48411343
99Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.48105742
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47358237
101Vibrio cholerae infection_Homo sapiens_hsa051100.46913628
102Neurotrophin signaling pathway_Homo sapiens_hsa047220.46033131
103Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.43993524
104Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43380820
105Shigellosis_Homo sapiens_hsa051310.43316662
106Proteoglycans in cancer_Homo sapiens_hsa052050.42396998
107Pancreatic cancer_Homo sapiens_hsa052120.42051177
108Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.41629951
109Renal cell carcinoma_Homo sapiens_hsa052110.40810460
110Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.39873744
111Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39405793
112Toxoplasmosis_Homo sapiens_hsa051450.38508553
113Leukocyte transendothelial migration_Homo sapiens_hsa046700.37854651
114Inositol phosphate metabolism_Homo sapiens_hsa005620.37812192
115Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37242938
116Adherens junction_Homo sapiens_hsa045200.36655250
117Pathways in cancer_Homo sapiens_hsa052000.35949992
118Estrogen signaling pathway_Homo sapiens_hsa049150.35848669
119Phenylalanine metabolism_Homo sapiens_hsa003600.34574435
120Carbon metabolism_Homo sapiens_hsa012000.34349554
121RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.34341324
122Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.33641682
123Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.32866612
124Fatty acid elongation_Homo sapiens_hsa000620.32765035
125Steroid biosynthesis_Homo sapiens_hsa001000.32588945
126NOD-like receptor signaling pathway_Homo sapiens_hsa046210.31003649
127Glucagon signaling pathway_Homo sapiens_hsa049220.30360909
128Endometrial cancer_Homo sapiens_hsa052130.29374612
129Hippo signaling pathway_Homo sapiens_hsa043900.29170882
130Sulfur relay system_Homo sapiens_hsa041220.28892870
131Hepatitis C_Homo sapiens_hsa051600.28791322
132VEGF signaling pathway_Homo sapiens_hsa043700.28472355
133Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27784530
134Intestinal immune network for IgA production_Homo sapiens_hsa046720.27492189

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