NMT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of two N-myristoyltransferase proteins. N-terminal myristoylation is a lipid modification that is involved in regulating the function and localization of signaling proteins. The encoded protein catalyzes the addition of a myristoyl group to the N-terminal glycine residue of many signaling proteins, including the human immunodeficiency virus type 1 (HIV-1) proteins, Gag and Nef. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cullin deneddylation (GO:0010388)5.56094823
2behavioral response to nicotine (GO:0035095)5.20488075
3protein deneddylation (GO:0000338)5.01165915
4negative regulation of dendrite morphogenesis (GO:0050774)4.77556872
5piRNA metabolic process (GO:0034587)4.73037318
6presynaptic membrane assembly (GO:0097105)4.48878218
7DNA methylation involved in gamete generation (GO:0043046)4.20700859
8synaptic vesicle docking involved in exocytosis (GO:0016081)4.17338058
9fucose catabolic process (GO:0019317)4.02497860
10L-fucose metabolic process (GO:0042354)4.02497860
11L-fucose catabolic process (GO:0042355)4.02497860
12positive regulation of mitochondrial fission (GO:0090141)3.93283834
13presynaptic membrane organization (GO:0097090)3.79689812
14postsynaptic membrane organization (GO:0001941)3.74543973
15neurotransmitter-gated ion channel clustering (GO:0072578)3.73311312
16inositol phosphate catabolic process (GO:0071545)3.69448263
17DNA double-strand break processing (GO:0000729)3.67240663
18regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.61275811
19platelet dense granule organization (GO:0060155)3.60362902
20intraciliary transport (GO:0042073)3.59738353
21response to pheromone (GO:0019236)3.53765493
22negative regulation of dendrite development (GO:2000171)3.47830054
23sulfation (GO:0051923)3.44253872
24detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.39497693
25somite development (GO:0061053)3.34661304
26gamma-aminobutyric acid transport (GO:0015812)3.25877803
27replication fork processing (GO:0031297)3.25430345
28neuron cell-cell adhesion (GO:0007158)3.22123249
29startle response (GO:0001964)3.21634955
30tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.17983097
31RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.17983097
32regulation of meiosis I (GO:0060631)3.14181449
33regulation of fibroblast apoptotic process (GO:2000269)3.13221360
34meiotic chromosome segregation (GO:0045132)3.11781835
35protein polyglutamylation (GO:0018095)3.11666227
36cilium morphogenesis (GO:0060271)3.09563117
37cellular ketone body metabolic process (GO:0046950)3.02828114
38protein neddylation (GO:0045116)3.00394639
39positive regulation of prostaglandin secretion (GO:0032308)2.97484880
40ER overload response (GO:0006983)2.96450827
41purine nucleobase biosynthetic process (GO:0009113)2.95021690
42protein K11-linked deubiquitination (GO:0035871)2.94940197
43transferrin transport (GO:0033572)2.92368971
44head development (GO:0060322)2.92110554
45poly(A)+ mRNA export from nucleus (GO:0016973)2.90515133
46signal peptide processing (GO:0006465)2.90111051
477-methylguanosine mRNA capping (GO:0006370)2.88627413
48nonmotile primary cilium assembly (GO:0035058)2.88417980
49C4-dicarboxylate transport (GO:0015740)2.88252488
50regulation of synaptic vesicle exocytosis (GO:2000300)2.87716476
51DNA synthesis involved in DNA repair (GO:0000731)2.87637164
52positive regulation of protein homodimerization activity (GO:0090073)2.86241595
53pyrimidine nucleobase catabolic process (GO:0006208)2.85915672
547-methylguanosine RNA capping (GO:0009452)2.84576965
55RNA capping (GO:0036260)2.84576965
56regulation of hexokinase activity (GO:1903299)2.83887713
57regulation of glucokinase activity (GO:0033131)2.83887713
58regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.82039873
59regulation of mitotic spindle checkpoint (GO:1903504)2.82039873
60positive regulation of fatty acid transport (GO:2000193)2.81679157
61synaptonemal complex organization (GO:0070193)2.81671830
62negative regulation of synaptic transmission, GABAergic (GO:0032229)2.79651829
63positive regulation of meiosis (GO:0045836)2.79237118
64preassembly of GPI anchor in ER membrane (GO:0016254)2.78857790
65negative regulation of mast cell activation (GO:0033004)2.78548149
66synaptonemal complex assembly (GO:0007130)2.77468341
67lymphangiogenesis (GO:0001946)2.76781299
68epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.75485247
69protein K6-linked ubiquitination (GO:0085020)2.75475062
70* protein-cofactor linkage (GO:0018065)2.75327575
71cytochrome complex assembly (GO:0017004)2.75056063
72male meiosis (GO:0007140)2.74617638
73DNA strand renaturation (GO:0000733)2.71863094
74inositol phosphate dephosphorylation (GO:0046855)2.70680124
75phosphorylated carbohydrate dephosphorylation (GO:0046838)2.70680124
76protein complex biogenesis (GO:0070271)2.69650598
77trivalent inorganic cation transport (GO:0072512)2.69310061
78ferric iron transport (GO:0015682)2.69310061
79ketone body metabolic process (GO:1902224)2.68847352
80cAMP catabolic process (GO:0006198)2.68833250
81lactate metabolic process (GO:0006089)2.68210196
82inner ear receptor stereocilium organization (GO:0060122)2.67874795
83negative regulation of fibroblast apoptotic process (GO:2000270)2.67872561
84histone H2A acetylation (GO:0043968)2.67758240
85drug catabolic process (GO:0042737)2.67406942
86negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.67200514
87microtubule depolymerization (GO:0007019)2.66807066
88cerebral cortex radially oriented cell migration (GO:0021799)2.66071737
89tongue development (GO:0043586)2.64458804
90behavioral response to ethanol (GO:0048149)2.64034415
91mannosylation (GO:0097502)2.63164204
92regulation of synaptic vesicle transport (GO:1902803)2.62715344
93protein localization to cilium (GO:0061512)2.61342848
94regulation of memory T cell differentiation (GO:0043380)2.61067509
95urinary tract smooth muscle contraction (GO:0014848)2.59919445
96negative regulation of meiosis (GO:0045835)2.59255293
97positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.57638791
98endoderm formation (GO:0001706)2.57395036
99reflex (GO:0060004)2.57196634
100nephron tubule morphogenesis (GO:0072078)2.56931250
101nephron epithelium morphogenesis (GO:0072088)2.56931250
102negative regulation of systemic arterial blood pressure (GO:0003085)2.56294679
103exogenous drug catabolic process (GO:0042738)2.55147737
104limb bud formation (GO:0060174)2.54713965
105anterograde synaptic vesicle transport (GO:0048490)2.54628987
106regulation of mitochondrial fission (GO:0090140)2.54041465
107regulation of sequestering of triglyceride (GO:0010889)2.53375577
108GPI anchor metabolic process (GO:0006505)2.52308848
109regulation of hippo signaling (GO:0035330)2.51690302
110regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.51272411
111meiotic nuclear division (GO:0007126)2.51002020
112axoneme assembly (GO:0035082)2.50222969
113reciprocal DNA recombination (GO:0035825)2.49924095
114reciprocal meiotic recombination (GO:0007131)2.49924095
115regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.49860913
116kinetochore assembly (GO:0051382)2.49576324
117chromatin remodeling at centromere (GO:0031055)2.49557206
118adult feeding behavior (GO:0008343)2.49192010
119positive regulation of icosanoid secretion (GO:0032305)2.49013103
120positive regulation of meiotic cell cycle (GO:0051446)2.48814495
1212-deoxyribonucleotide biosynthetic process (GO:0009265)2.48744075
122deoxyribose phosphate biosynthetic process (GO:0046385)2.48744075
123anterograde axon cargo transport (GO:0008089)2.48730288
124serotonin receptor signaling pathway (GO:0007210)2.48331307
125kinetochore organization (GO:0051383)2.48254199
126protein localization to microtubule cytoskeleton (GO:0072698)2.47903082
127vocalization behavior (GO:0071625)2.47652001
128cyclic nucleotide catabolic process (GO:0009214)2.47611644
129respiratory chain complex IV assembly (GO:0008535)2.46913269
130mitochondrial respiratory chain complex I assembly (GO:0032981)2.46822460
131NADH dehydrogenase complex assembly (GO:0010257)2.46822460
132mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.46822460
133negative regulation of glycogen biosynthetic process (GO:0045719)2.45958561
134germ cell migration (GO:0008354)2.44970194
135regulation of cilium movement (GO:0003352)2.44917427
136DNA catabolic process, exonucleolytic (GO:0000738)2.43753823
137protein K11-linked ubiquitination (GO:0070979)2.43470142
138photoreceptor cell development (GO:0042461)2.42992632
139nucleobase biosynthetic process (GO:0046112)2.42387742
140phospholipid homeostasis (GO:0055091)2.41266820
141cilium organization (GO:0044782)2.41187230
142negative regulation of telomere maintenance (GO:0032205)2.40513071
143deoxyribonucleotide biosynthetic process (GO:0009263)2.38874750
144inner ear receptor cell development (GO:0060119)2.38460424
145positive regulation of amino acid transport (GO:0051957)2.38393131
146maturation of 5.8S rRNA (GO:0000460)2.38207372
147CENP-A containing nucleosome assembly (GO:0034080)2.37255681
148neural tube formation (GO:0001841)2.37111311
149cilium assembly (GO:0042384)2.37060922
150regulation of synapse maturation (GO:0090128)2.36896427
151regulation of prostaglandin secretion (GO:0032306)2.36827318
152mitochondrial respiratory chain complex assembly (GO:0033108)2.36332271
153regulation of mitochondrial translation (GO:0070129)2.36075004
154somatic hypermutation of immunoglobulin genes (GO:0016446)2.35480452
155somatic diversification of immune receptors via somatic mutation (GO:0002566)2.35480452
156adenosine metabolic process (GO:0046085)2.34071277
157chromosome organization involved in meiosis (GO:0070192)2.34058538
158regulation of lipoprotein metabolic process (GO:0050746)2.33943878
159regulation of non-canonical Wnt signaling pathway (GO:2000050)2.33908069
160protein localization to cytoskeleton (GO:0044380)2.33404012
161cornea development in camera-type eye (GO:0061303)2.32761041
162positive regulation of response to oxidative stress (GO:1902884)2.32536476
163positive regulation of cellular response to oxidative stress (GO:1900409)2.32536476
164protein K63-linked deubiquitination (GO:0070536)2.32421871
165protein localization to microtubule (GO:0035372)2.32164819
166water-soluble vitamin biosynthetic process (GO:0042364)2.31970196
167positive regulation of cardiac muscle cell differentiation (GO:2000727)2.31588338
168DNA replication checkpoint (GO:0000076)2.31502603
169peptidyl-histidine modification (GO:0018202)2.31501060
170sister chromatid cohesion (GO:0007062)2.31129234
171deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.30994032
172tryptophan catabolic process (GO:0006569)2.30177056
173indole-containing compound catabolic process (GO:0042436)2.30177056
174indolalkylamine catabolic process (GO:0046218)2.30177056
175nucleobase catabolic process (GO:0046113)2.30104941
176ubiquinone biosynthetic process (GO:0006744)2.29736605
177ubiquinone metabolic process (GO:0006743)2.29423192
178synaptic transmission, cholinergic (GO:0007271)2.28914114
179protein K48-linked deubiquitination (GO:0071108)2.28811001
180synaptic vesicle exocytosis (GO:0016079)2.28758682
181photoreceptor cell maintenance (GO:0045494)2.28757823
182dentate gyrus development (GO:0021542)2.28585086
183positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.28453039
184negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.26347888
185regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.26098561
186branched-chain amino acid catabolic process (GO:0009083)2.23089405
187indolalkylamine metabolic process (GO:0006586)2.22998528
188smoothened signaling pathway (GO:0007224)2.22850884

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse4.31645530
2ZNF274_21170338_ChIP-Seq_K562_Hela4.04102092
3GBX2_23144817_ChIP-Seq_PC3_Human3.71314883
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.12403693
5E2F7_22180533_ChIP-Seq_HELA_Human2.98097276
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.55060435
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.47433527
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.43967804
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.36567506
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.27071263
11EZH2_22144423_ChIP-Seq_EOC_Human2.23155228
12TAF15_26573619_Chip-Seq_HEK293_Human2.22301584
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.20983818
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.16218069
15SALL1_21062744_ChIP-ChIP_HESCs_Human2.08186137
16FUS_26573619_Chip-Seq_HEK293_Human2.03496316
17EST1_17652178_ChIP-ChIP_JURKAT_Human1.96688335
18RNF2_27304074_Chip-Seq_NSC_Mouse1.95023662
19EWS_26573619_Chip-Seq_HEK293_Human1.91207641
20PCGF2_27294783_Chip-Seq_ESCs_Mouse1.90226990
21* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.89960754
22PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.88517211
23PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.86866720
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.86025463
25P300_19829295_ChIP-Seq_ESCs_Human1.84910409
26PIAS1_25552417_ChIP-Seq_VCAP_Human1.84844415
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.83731249
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.83217410
29KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.83214396
30GABP_17652178_ChIP-ChIP_JURKAT_Human1.78383201
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.77088146
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.76066739
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.75073467
34BCAT_22108803_ChIP-Seq_LS180_Human1.74374786
35THAP11_20581084_ChIP-Seq_MESCs_Mouse1.74342647
36HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.72832067
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.71852207
38CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.68357903
39NOTCH1_21737748_ChIP-Seq_TLL_Human1.59506689
40IGF1R_20145208_ChIP-Seq_DFB_Human1.59418807
41MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.57824265
42EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.57766145
43NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.56888824
44IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.55413594
45CBP_20019798_ChIP-Seq_JUKART_Human1.55413594
46CREB1_15753290_ChIP-ChIP_HEK293T_Human1.54665259
47UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.53580154
48SMAD4_21799915_ChIP-Seq_A2780_Human1.52974143
49ELK1_19687146_ChIP-ChIP_HELA_Human1.50760650
50SRF_21415370_ChIP-Seq_HL-1_Mouse1.50520222
51FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.48873436
52BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.45761216
53NR3C1_21868756_ChIP-Seq_MCF10A_Human1.45614010
54VDR_22108803_ChIP-Seq_LS180_Human1.45580422
55POU5F1_16153702_ChIP-ChIP_HESCs_Human1.45186751
56* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.44315689
57PADI4_21655091_ChIP-ChIP_MCF-7_Human1.42463485
58PCGF2_27294783_Chip-Seq_NPCs_Mouse1.39434413
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38933812
60* NANOG_18555785_Chip-Seq_ESCs_Mouse1.38257340
61* E2F1_18555785_Chip-Seq_ESCs_Mouse1.37961475
62KLF5_20875108_ChIP-Seq_MESCs_Mouse1.35939317
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.35465485
64AR_21572438_ChIP-Seq_LNCaP_Human1.33154772
65* STAT3_18555785_Chip-Seq_ESCs_Mouse1.31459552
66* P53_22387025_ChIP-Seq_ESCs_Mouse1.31421215
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31174656
68CBX2_27304074_Chip-Seq_ESCs_Mouse1.30957531
69TP53_22573176_ChIP-Seq_HFKS_Human1.30870084
70SOX9_26525672_Chip-Seq_HEART_Mouse1.30714164
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29322187
72SMAD_19615063_ChIP-ChIP_OVARY_Human1.29070994
73MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29044109
74* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.29024879
75ER_23166858_ChIP-Seq_MCF-7_Human1.28715005
76PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28532678
77* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.28156556
78E2F4_17652178_ChIP-ChIP_JURKAT_Human1.28018921
79YY1_21170310_ChIP-Seq_MESCs_Mouse1.27318564
80TCF4_22108803_ChIP-Seq_LS180_Human1.26877764
81* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.24886677
82NFE2_27457419_Chip-Seq_LIVER_Mouse1.24795530
83RUNX2_22187159_ChIP-Seq_PCA_Human1.24675192
84IRF1_19129219_ChIP-ChIP_H3396_Human1.24419379
85* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.23599810
86* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22777011
87TCF4_23295773_ChIP-Seq_U87_Human1.22691471
88* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.22177026
89* FOXA1_25329375_ChIP-Seq_VCAP_Human1.22177026
90CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.21672949
91HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.21103414
92JUN_21703547_ChIP-Seq_K562_Human1.20508485
93TP63_19390658_ChIP-ChIP_HaCaT_Human1.20058384
94CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.18868078
95NANOG_19829295_ChIP-Seq_ESCs_Human1.18835257
96SOX2_19829295_ChIP-Seq_ESCs_Human1.18835257
97EED_16625203_ChIP-ChIP_MESCs_Mouse1.18548285
98RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17165055
99VDR_23849224_ChIP-Seq_CD4+_Human1.16315547
100CMYC_18555785_Chip-Seq_ESCs_Mouse1.15802827
101STAT3_23295773_ChIP-Seq_U87_Human1.14626742
102AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14582596
103RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.13569173
104P300_18555785_Chip-Seq_ESCs_Mouse1.13521018
105* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.13355646
106FLI1_21867929_ChIP-Seq_TH2_Mouse1.13344615
107SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.13331192
108CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12354633
109* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11482733
110MYC_18940864_ChIP-ChIP_HL60_Human1.11278677
111* SOX2_18555785_Chip-Seq_ESCs_Mouse1.10917545
112CJUN_26792858_Chip-Seq_BT549_Human1.10839580
113* NMYC_18555785_Chip-Seq_ESCs_Mouse1.09487568
114SMAD3_21741376_ChIP-Seq_EPCs_Human1.08788083
115AR_20517297_ChIP-Seq_VCAP_Human1.08060024
116KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.07650433
117KDM2B_26808549_Chip-Seq_REH_Human1.07399607
118PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.06640414
119POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06394907
120TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06394907
121* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.06236492
122CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06142562
123PRDM14_20953172_ChIP-Seq_ESCs_Human1.05631295
124SMAD4_21741376_ChIP-Seq_EPCs_Human1.05174234
125SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.04590492
126CRX_20693478_ChIP-Seq_RETINA_Mouse1.04577902
127ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.04225836
128EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03991494
129HOXB4_20404135_ChIP-ChIP_EML_Mouse1.03937301
130* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02929057
131POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.02571758
132ETV2_25802403_ChIP-Seq_MESCs_Mouse1.02528973
133SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02355917
134EZH2_27294783_Chip-Seq_NPCs_Mouse1.01516308
135CDX2_22108803_ChIP-Seq_LS180_Human1.01270799
136NELFA_20434984_ChIP-Seq_ESCs_Mouse1.00787345
137AR_25329375_ChIP-Seq_VCAP_Human1.00226952
138MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00095281
139* REST_19997604_ChIP-ChIP_NEURONS_Mouse1.00063404
140FOXP3_21729870_ChIP-Seq_TREG_Human0.99503907
141* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99365448
142MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.99035908
143OCT4_18555785_Chip-Seq_ESCs_Mouse0.98357378
144REST_21632747_ChIP-Seq_MESCs_Mouse0.97278738
145SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.96899019
146P53_22127205_ChIP-Seq_FIBROBLAST_Human0.94949295

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation4.58688854
2MP0003787_abnormal_imprinting3.81339611
3MP0002102_abnormal_ear_morphology3.35368283
4MP0005646_abnormal_pituitary_gland3.02560104
5MP0001188_hyperpigmentation2.85204420
6MP0003880_abnormal_central_pattern2.66899112
7MP0003121_genomic_imprinting2.65758638
8MP0006072_abnormal_retinal_apoptosis2.56954822
9MP0003122_maternal_imprinting2.53694742
10MP0003123_paternal_imprinting2.53181544
11MP0009697_abnormal_copulation2.43944702
12MP0000569_abnormal_digit_pigmentation2.42101825
13MP0005171_absent_coat_pigmentation2.38995736
14MP0008058_abnormal_DNA_repair2.24986468
15MP0001986_abnormal_taste_sensitivity2.24545002
16MP0005551_abnormal_eye_electrophysiolog2.21869574
17MP0003786_premature_aging2.12807901
18MP0002876_abnormal_thyroid_physiology2.12538493
19MP0008875_abnormal_xenobiotic_pharmacok2.10879800
20MP0003011_delayed_dark_adaptation2.07881542
21MP0004885_abnormal_endolymph2.07324137
22MP0006292_abnormal_olfactory_placode2.03649992
23MP0002736_abnormal_nociception_after2.02495432
24MP0010386_abnormal_urinary_bladder2.02212992
25MP0005253_abnormal_eye_physiology1.99554248
26MP0002735_abnormal_chemical_nociception1.99268955
27MP0005084_abnormal_gallbladder_morpholo1.94311322
28MP0002938_white_spotting1.90090311
29MP0001984_abnormal_olfaction1.87434337
30MP0004133_heterotaxia1.87010293
31MP0008995_early_reproductive_senescence1.81176634
32MP0002234_abnormal_pharynx_morphology1.75969207
33MP0009046_muscle_twitch1.72594215
34MP0002160_abnormal_reproductive_system1.71663121
35MP0001968_abnormal_touch/_nociception1.70458607
36MP0008007_abnormal_cellular_replicative1.68305584
37MP0000516_abnormal_urinary_system1.67940872
38MP0005367_renal/urinary_system_phenotyp1.67940872
39MP0009745_abnormal_behavioral_response1.66359039
40MP0001879_abnormal_lymphatic_vessel1.66044528
41MP0010094_abnormal_chromosome_stability1.65879645
42MP0002572_abnormal_emotion/affect_behav1.63413862
43MP0002734_abnormal_mechanical_nocicepti1.61359483
44MP0002063_abnormal_learning/memory/cond1.59071214
45MP0003890_abnormal_embryonic-extraembry1.57210743
46MP0003252_abnormal_bile_duct1.56418403
47MP0000015_abnormal_ear_pigmentation1.55267158
48MP0010368_abnormal_lymphatic_system1.51519932
49MP0003635_abnormal_synaptic_transmissio1.51426677
50MP0002751_abnormal_autonomic_nervous1.50457896
51MP0002210_abnormal_sex_determination1.50046252
52MP0002928_abnormal_bile_duct1.47915574
53MP0001529_abnormal_vocalization1.44608307
54MP0006276_abnormal_autonomic_nervous1.43940775
55MP0000566_synostosis1.43433354
56MP0001177_atelectasis1.38800333
57MP0005499_abnormal_olfactory_system1.38666256
58MP0005394_taste/olfaction_phenotype1.38666256
59MP0005645_abnormal_hypothalamus_physiol1.38194862
60MP0004270_analgesia1.37215198
61MP0002064_seizures1.36152904
62MP0004859_abnormal_synaptic_plasticity1.36112779
63MP0008775_abnormal_heart_ventricle1.35281635
64MP0004147_increased_porphyrin_level1.35141725
65MP0004742_abnormal_vestibular_system1.34309730
66MP0008057_abnormal_DNA_replication1.30632575
67MP0005389_reproductive_system_phenotype1.30211522
68MP0000778_abnormal_nervous_system1.30177727
69MP0008872_abnormal_physiological_respon1.27907214
70MP0001502_abnormal_circadian_rhythm1.26428530
71MP0000647_abnormal_sebaceous_gland1.24037305
72MP0010329_abnormal_lipoprotein_level1.23701211
73MP0008789_abnormal_olfactory_epithelium1.23621464
74MP0002272_abnormal_nervous_system1.22953171
75MP0003950_abnormal_plasma_membrane1.20193997
76MP0000427_abnormal_hair_cycle1.18608697
77MP0002822_catalepsy1.17963451
78MP0005195_abnormal_posterior_eye1.16522565
79MP0001919_abnormal_reproductive_system1.16265926
80MP0002067_abnormal_sensory_capabilities1.16209101
81MP0004130_abnormal_muscle_cell1.16044512
82MP0009780_abnormal_chondrocyte_physiolo1.15033777
83MP0005187_abnormal_penis_morphology1.14439581
84MP0003879_abnormal_hair_cell1.14023868
85MP0003941_abnormal_skin_development1.13685261
86MP0001346_abnormal_lacrimal_gland1.12819995
87MP0002638_abnormal_pupillary_reflex1.12349131
88MP0003183_abnormal_peptide_metabolism1.11386515
89MP0002184_abnormal_innervation1.11339989
90MP0004215_abnormal_myocardial_fiber1.10608148
91MP0002557_abnormal_social/conspecific_i1.10050728
92MP0002733_abnormal_thermal_nociception1.09284935
93MP0001764_abnormal_homeostasis1.07135213
94MP0001929_abnormal_gametogenesis1.07051671
95MP0001293_anophthalmia1.05102603
96MP0000631_abnormal_neuroendocrine_gland1.04665624
97MP0001145_abnormal_male_reproductive1.04310046
98MP0000681_abnormal_thyroid_gland1.03792951
99MP0000372_irregular_coat_pigmentation1.03064811
100MP0001486_abnormal_startle_reflex1.02953269
101MP0000653_abnormal_sex_gland1.02351360
102MP0003698_abnormal_male_reproductive1.02053337
103MP0005391_vision/eye_phenotype1.01864107
104MP0003693_abnormal_embryo_hatching1.01811149
105MP0009384_cardiac_valve_regurgitation1.01169622
106MP0000026_abnormal_inner_ear1.00844799
107MP0005386_behavior/neurological_phenoty1.00622410
108MP0004924_abnormal_behavior1.00622410
109MP0005595_abnormal_vascular_smooth0.99800927
110MP0003315_abnormal_perineum_morphology0.98958884
111MP0001119_abnormal_female_reproductive0.96574517
112MP0001270_distended_abdomen0.95491534
113MP0003937_abnormal_limbs/digits/tail_de0.94925521
114MP0004043_abnormal_pH_regulation0.94096225
115MP0002837_dystrophic_cardiac_calcinosis0.93227868
116MP0009250_abnormal_appendicular_skeleto0.91917607
117MP0008932_abnormal_embryonic_tissue0.91567764
118MP0004782_abnormal_surfactant_physiolog0.91110051
119MP0010030_abnormal_orbit_morphology0.90939060
120MP0003195_calcinosis0.89183464
121MP0003136_yellow_coat_color0.88956473
122MP0001905_abnormal_dopamine_level0.88538285
123MP0003943_abnormal_hepatobiliary_system0.88504814
124MP0003186_abnormal_redox_activity0.88333693
125MP0005174_abnormal_tail_pigmentation0.88068086
126MP0002752_abnormal_somatic_nervous0.86116644
127MP0005365_abnormal_bile_salt0.85472443
128MP0002277_abnormal_respiratory_mucosa0.85332719
129MP0005503_abnormal_tendon_morphology0.85194850
130MP0000678_abnormal_parathyroid_gland0.84779638
131MP0002163_abnormal_gland_morphology0.84453912
132MP0003077_abnormal_cell_cycle0.83569516
133MP0003111_abnormal_nucleus_morphology0.83057690
134MP0001299_abnormal_eye_distance/0.82994733
135MP0003119_abnormal_digestive_system0.82176485
136MP0000049_abnormal_middle_ear0.80991642
137MP0006054_spinal_hemorrhage0.80908519
138MP0004811_abnormal_neuron_physiology0.80352459
139MP0002933_joint_inflammation0.80087501
140MP0000538_abnormal_urinary_bladder0.79386567
141MP0000230_abnormal_systemic_arterial0.78240421
142MP0002233_abnormal_nose_morphology0.77746533
143MP0001501_abnormal_sleep_pattern0.77407322
144MP0004142_abnormal_muscle_tone0.77012251
145MP0001963_abnormal_hearing_physiology0.76245023
146MP0001186_pigmentation_phenotype0.75421670
147MP0001970_abnormal_pain_threshold0.73002608
148MP0003755_abnormal_palate_morphology0.71530887
149MP0004957_abnormal_blastocyst_morpholog0.70993925
150MP0002095_abnormal_skin_pigmentation0.68145774
151MP0003718_maternal_effect0.67382218
152MP0001485_abnormal_pinna_reflex0.66854974
153MP0000749_muscle_degeneration0.66094838
154MP0008260_abnormal_autophagy0.65577362

Predicted human phenotypes

RankGene SetZ-score
1Abnormal hair whorl (HP:0010721)4.82653930
2Molar tooth sign on MRI (HP:0002419)4.03941713
3Abnormality of midbrain morphology (HP:0002418)4.03941713
4Focal motor seizures (HP:0011153)3.80873560
5Febrile seizures (HP:0002373)3.75415248
6Type II lissencephaly (HP:0007260)3.74156209
7Nephrogenic diabetes insipidus (HP:0009806)3.63606336
8Medial flaring of the eyebrow (HP:0010747)3.62698204
9Gait imbalance (HP:0002141)3.62392343
10Congenital primary aphakia (HP:0007707)3.60867646
11Nephronophthisis (HP:0000090)3.59118587
12Abnormality of the renal cortex (HP:0011035)3.54312511
13Poor coordination (HP:0002370)3.41041638
14Hypothermia (HP:0002045)3.37451922
15Retinal dysplasia (HP:0007973)3.35556018
16Hyperventilation (HP:0002883)3.34081069
17Abnormality of the labia minora (HP:0012880)3.31892355
18Epileptic encephalopathy (HP:0200134)3.22278045
19Abnormality of the renal medulla (HP:0100957)3.18040998
20Atonic seizures (HP:0010819)3.16304158
21Renal cortical cysts (HP:0000803)3.09406060
22Pancreatic fibrosis (HP:0100732)2.91412119
23Congenital stationary night blindness (HP:0007642)2.89727542
24Protruding tongue (HP:0010808)2.84400558
25Papillary thyroid carcinoma (HP:0002895)2.81933615
26Acute necrotizing encephalopathy (HP:0006965)2.81495837
27Chromosomal breakage induced by crosslinking agents (HP:0003221)2.80526369
28Increased corneal curvature (HP:0100692)2.77357426
29Keratoconus (HP:0000563)2.77357426
30Abolished electroretinogram (ERG) (HP:0000550)2.76213254
31Cerebellar dysplasia (HP:0007033)2.72981546
32Absent eyebrow (HP:0002223)2.70933116
33Genital tract atresia (HP:0001827)2.69768771
34Chromsome breakage (HP:0040012)2.69006842
35Birth length less than 3rd percentile (HP:0003561)2.67437632
36Chorioretinal atrophy (HP:0000533)2.66370112
37Azoospermia (HP:0000027)2.65405004
38Abnormal spermatogenesis (HP:0008669)2.64273386
39Aplasia/Hypoplasia of the tongue (HP:0010295)2.63411799
40True hermaphroditism (HP:0010459)2.63299817
41Progressive macrocephaly (HP:0004481)2.63019967
42Vaginal atresia (HP:0000148)2.62140316
43Inability to walk (HP:0002540)2.61894371
44Pendular nystagmus (HP:0012043)2.61862990
45Abnormal mitochondria in muscle tissue (HP:0008316)2.61543440
46Lissencephaly (HP:0001339)2.59704691
47Optic nerve hypoplasia (HP:0000609)2.57057682
48Sclerocornea (HP:0000647)2.55033133
49Tubular atrophy (HP:0000092)2.54300638
50Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.49431824
51Prominent supraorbital ridges (HP:0000336)2.49054483
52Toxemia of pregnancy (HP:0100603)2.44380709
53Pachygyria (HP:0001302)2.44129506
54Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.43217547
55Abnormality of alanine metabolism (HP:0010916)2.43217547
56Hyperalaninemia (HP:0003348)2.43217547
57Thyroid carcinoma (HP:0002890)2.41125817
58Attenuation of retinal blood vessels (HP:0007843)2.36561434
59Cystic liver disease (HP:0006706)2.35313322
60Degeneration of anterior horn cells (HP:0002398)2.34030647
61Abnormality of the anterior horn cell (HP:0006802)2.34030647
62Progressive inability to walk (HP:0002505)2.31991972
63Abnormal biliary tract physiology (HP:0012439)2.30794162
64Bile duct proliferation (HP:0001408)2.30794162
65Alveolar cell carcinoma (HP:0006519)2.30366818
66Aplasia/Hypoplasia of the tibia (HP:0005772)2.26430776
67Abnormal drinking behavior (HP:0030082)2.20062542
68Polydipsia (HP:0001959)2.20062542
69Thyroiditis (HP:0100646)2.18748107
70Pheochromocytoma (HP:0002666)2.17789463
71Chronic hepatic failure (HP:0100626)2.17326466
72Preaxial hand polydactyly (HP:0001177)2.14683997
73Abnormality of DNA repair (HP:0003254)2.14363822
74Congenital hepatic fibrosis (HP:0002612)2.13913903
75Conical tooth (HP:0000698)2.11033506
76Congenital, generalized hypertrichosis (HP:0004540)2.10803762
77Neuroendocrine neoplasm (HP:0100634)2.10752744
78Increased CSF lactate (HP:0002490)2.10482103
79Short tibia (HP:0005736)2.10066791
80Thyroid-stimulating hormone excess (HP:0002925)2.09964183
81Abnormality of incisor morphology (HP:0011063)2.09369148
82Facial cleft (HP:0002006)2.08938126
83Mitochondrial inheritance (HP:0001427)2.05809295
84Aplasia/Hypoplasia of the lens (HP:0008063)2.05249349
85Type I transferrin isoform profile (HP:0003642)2.05058440
86Progressive cerebellar ataxia (HP:0002073)2.02364978
87Large for gestational age (HP:0001520)2.02096185
88Failure to thrive in infancy (HP:0001531)2.01990935
89Disproportionate short-trunk short stature (HP:0003521)2.01444200
90Agnosia (HP:0010524)2.00302232
91Limb dystonia (HP:0002451)1.99314781
92Nephroblastoma (Wilms tumor) (HP:0002667)1.98668341
93Embryonal renal neoplasm (HP:0011794)1.97537872
94Polyphagia (HP:0002591)1.97059847
95Meningioma (HP:0002858)1.96233717
96Neoplasm of the adrenal gland (HP:0100631)1.95881267
97Fetal akinesia sequence (HP:0001989)1.95382606
98Broad foot (HP:0001769)1.95079242
99Hypoplasia of the fovea (HP:0007750)1.94642926
100Aplasia/Hypoplasia of the fovea (HP:0008060)1.94642926
101Postaxial foot polydactyly (HP:0001830)1.93978403
102Anencephaly (HP:0002323)1.93598061
103Pancreatic cysts (HP:0001737)1.92143507
104Occipital encephalocele (HP:0002085)1.91602560
105Aganglionic megacolon (HP:0002251)1.91581100
106Hypoproteinemia (HP:0003075)1.90947892
107Type 2 muscle fiber atrophy (HP:0003554)1.90669963
108Neoplasm of the tracheobronchial system (HP:0100552)1.90166527
109Septo-optic dysplasia (HP:0100842)1.89739069
1103-Methylglutaconic aciduria (HP:0003535)1.89397034
111Genetic anticipation (HP:0003743)1.89371182
112Gaze-evoked nystagmus (HP:0000640)1.88605566
113Abnormality of the nasal septum (HP:0000419)1.88427876
114Blue irides (HP:0000635)1.85155602
115Asymmetry of the thorax (HP:0001555)1.84601770
116Volvulus (HP:0002580)1.84199553
117Arthropathy (HP:0003040)1.83188062
118Tongue fasciculations (HP:0001308)1.83140756
119Aplasia/Hypoplasia of the uvula (HP:0010293)1.82286239
120Male pseudohermaphroditism (HP:0000037)1.82049205
121Acute encephalopathy (HP:0006846)1.81621556
122Sleep apnea (HP:0010535)1.80628841
123Severe combined immunodeficiency (HP:0004430)1.80613800
124Postaxial hand polydactyly (HP:0001162)1.80082947
125Aplasia/Hypoplasia of the sternum (HP:0006714)1.80079577
126Microvesicular hepatic steatosis (HP:0001414)1.79608595
127Anterior segment dysgenesis (HP:0007700)1.79523856
128Specific learning disability (HP:0001328)1.79388864
129Polyuria (HP:0000103)1.78094271
130Poor suck (HP:0002033)1.77119532
131Absent speech (HP:0001344)1.76545119
132Long foot (HP:0001833)1.76521148
133Abnormal lung lobation (HP:0002101)1.76147155
134Fair hair (HP:0002286)1.75760215
135Hypoplastic iliac wings (HP:0002866)1.75699775
136Abnormality of macular pigmentation (HP:0008002)1.75350463
137Broad-based gait (HP:0002136)1.74391727
138Stenosis of the external auditory canal (HP:0000402)1.74309190
139Epileptiform EEG discharges (HP:0011182)1.74066404
140Meckel diverticulum (HP:0002245)1.73992799
141Hemiparesis (HP:0001269)1.72865541
142Optic nerve coloboma (HP:0000588)1.72678939
143Ectopic kidney (HP:0000086)1.72412821
144Oligomenorrhea (HP:0000876)1.71779844
145Intestinal atresia (HP:0011100)1.71661670
146Patellar aplasia (HP:0006443)1.70860443
147Abnormality of the preputium (HP:0100587)1.70858624
148Median cleft lip (HP:0000161)1.70792916
149Supernumerary spleens (HP:0009799)1.69903329
150Absent eyelashes (HP:0000561)1.69558361
151Gonadotropin excess (HP:0000837)1.69227465
152Neoplasm of the adrenal cortex (HP:0100641)1.68986494
153Impulsivity (HP:0100710)1.68968595
154Abnormality of the diencephalon (HP:0010662)1.67903019
155Cystic hygroma (HP:0000476)1.67575879
156Astigmatism (HP:0000483)1.66728690
157Osteomalacia (HP:0002749)1.66580641
158Heterochromia iridis (HP:0001100)1.66071504
159Shoulder girdle muscle weakness (HP:0003547)1.65872846
160Severe muscular hypotonia (HP:0006829)1.65724019
161Abnormality of chromosome stability (HP:0003220)1.64980468
162Generalized hypopigmentation of hair (HP:0011358)1.64784622
163Stomach cancer (HP:0012126)1.64782576
164Widely spaced teeth (HP:0000687)1.64661700
165Abnormality of the ileum (HP:0001549)1.64647102
166Colon cancer (HP:0003003)1.64357992
167Dandy-Walker malformation (HP:0001305)1.64327939
168Fibular hypoplasia (HP:0003038)1.62133968
169Hyperglycinemia (HP:0002154)1.61978291
170Adrenal hypoplasia (HP:0000835)1.59497691
171Hyperlipoproteinemia (HP:0010980)1.57498023
172Bony spicule pigmentary retinopathy (HP:0007737)1.57295426
173Oligohydramnios (HP:0001562)1.56636985

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.56723175
2AKT33.82599150
3PRPF4B2.84767252
4MAP2K72.83968190
5SGK22.65694877
6MAP4K22.47857752
7TSSK62.46446689
8SIK32.37000941
9PLK22.34626018
10TLK12.28841169
11CCNB12.23957054
12EPHB22.21602640
13ACVR1B2.12824303
14TIE12.07748551
15MKNK22.06308869
16WNK41.99857522
17ZAK1.94597678
18NUAK11.92972402
19STK38L1.91431857
20GRK11.88900440
21ERBB31.85409140
22MAP3K121.84810642
23MAP3K41.83248808
24STK241.82539542
25BMPR1B1.81505344
26CDK81.76804353
27SGK4941.76118758
28SGK2231.76118758
29BCKDK1.71354018
30TXK1.69933082
31MKNK11.60457537
32MAPK131.59748008
33BMPR21.59148282
34TRIM281.57486362
35SGK31.52331516
36SRPK11.51340160
37YES11.50753388
38CAMKK21.49214885
39PAK31.46744251
40PLK31.44860186
41BRAF1.44305261
42NTRK31.43759665
43PNCK1.42509335
44PLK41.41626404
45DAPK11.39064261
46FRK1.38598734
47LIMK11.31633439
48PHKG21.21963813
49PHKG11.21963813
50TGFBR11.18237538
51STK391.16419065
52BCR1.16265715
53STK161.10102486
54CDK191.08831311
55PKN11.08631023
56EIF2AK11.07935177
57MARK11.06010088
58CDC71.05821484
59TAOK21.04601801
60BRSK21.04315417
61MYLK1.04079775
62VRK11.03963317
63EPHA41.01361790
64DAPK20.98385445
65ADRBK20.94109355
66NEK60.90610976
67EIF2AK30.87928010
68TAOK30.87573490
69BRSK10.87280407
70TGFBR20.86351824
71MAPK150.84973007
72BRD40.83151402
73MAP3K140.81896521
74ERBB20.79805179
75PDK40.78215712
76PDK30.78215712
77NEK10.77562616
78RPS6KB10.77551062
79PIK3CA0.77060922
80MINK10.75741214
81MAP2K40.74021338
82NTRK20.73543939
83CDK30.73536149
84NEK20.72941035
85WNK30.71208061
86FGFR20.67604301
87TAF10.65859154
88PASK0.65273171
89INSRR0.64651372
90PRKCG0.63355659
91PINK10.59916615
92EIF2AK20.57032696
93EPHA30.56991907
94PLK10.56483566
95BUB10.56008468
96PRKCE0.55801953
97RPS6KA20.54883827
98OBSCN0.54681368
99NME10.52463410
100DYRK1A0.51571308
101PAK60.51313472
102DYRK20.50912068
103PRKCQ0.49877037
104TEC0.49861685
105MUSK0.49724942
106ABL20.48659897
107PRKCH0.48286911
108SGK10.47884765
109IGF1R0.47479506
110ATR0.47413315
111ERBB40.47319355
112ITK0.47026405
113WEE10.46081705
114CDC42BPA0.45681802
115CSNK1G20.43970738
116FER0.43109000
117PDK20.42527831
118RPS6KA40.42400780
119ROCK10.42387948
120MAP2K20.42371117
121OXSR10.41460120
122STK110.41388263
123PRKG10.41279942
124RPS6KL10.40961491
125RPS6KC10.40961491
126MET0.40523777
127CSNK1G10.40145507
128TNIK0.39099142
129MAP2K10.38992314
130CAMK2D0.38631317
131ADRBK10.37881276
132ATM0.37585942
133IRAK30.36496133
134CAMK2B0.35615797
135KSR10.35489884
136NEK90.35399563
137RPS6KA60.34802164
138WNK10.34581294
139CHEK20.34504819
140CAMK2A0.34262808
141PRKD30.33858092
142PRKCI0.33436297
143AURKA0.31315110
144TNK20.31094116
145CAMK40.30875992
146GRK50.29142936
147PTK2B0.28825297
148GRK70.28042739
149CHEK10.27865342

Predicted pathways (KEGG)

RankGene SetZ-score
1Collecting duct acid secretion_Homo sapiens_hsa049662.77344317
2Synaptic vesicle cycle_Homo sapiens_hsa047212.74693600
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.69928927
4Proteasome_Homo sapiens_hsa030502.68984308
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.63806587
6Nicotine addiction_Homo sapiens_hsa050332.61022931
7Mismatch repair_Homo sapiens_hsa034302.55344784
8Basal transcription factors_Homo sapiens_hsa030222.54016731
9Protein export_Homo sapiens_hsa030602.34435546
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.26707163
11Homologous recombination_Homo sapiens_hsa034402.23882767
12Linoleic acid metabolism_Homo sapiens_hsa005912.18894510
13RNA polymerase_Homo sapiens_hsa030202.15046489
14Vibrio cholerae infection_Homo sapiens_hsa051102.14024374
15Butanoate metabolism_Homo sapiens_hsa006502.09868796
16Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.07834503
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.02534784
18Nitrogen metabolism_Homo sapiens_hsa009102.02123999
19Fanconi anemia pathway_Homo sapiens_hsa034602.01883688
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.99143162
21Propanoate metabolism_Homo sapiens_hsa006401.98071054
22Primary bile acid biosynthesis_Homo sapiens_hsa001201.97504598
23Oxidative phosphorylation_Homo sapiens_hsa001901.96823379
24Caffeine metabolism_Homo sapiens_hsa002321.93784613
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.93737348
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.93637388
27Nucleotide excision repair_Homo sapiens_hsa034201.86253646
28Taste transduction_Homo sapiens_hsa047421.80966644
29Tryptophan metabolism_Homo sapiens_hsa003801.79839781
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.77026542
31DNA replication_Homo sapiens_hsa030301.75879638
32Selenocompound metabolism_Homo sapiens_hsa004501.71109057
33Olfactory transduction_Homo sapiens_hsa047401.69301166
34RNA degradation_Homo sapiens_hsa030181.68848380
35Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.63577152
36Cell cycle_Homo sapiens_hsa041101.58507990
37Huntingtons disease_Homo sapiens_hsa050161.57633071
38Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.57326033
39Parkinsons disease_Homo sapiens_hsa050121.54787316
40SNARE interactions in vesicular transport_Homo sapiens_hsa041301.52251775
41Base excision repair_Homo sapiens_hsa034101.47556623
42RNA transport_Homo sapiens_hsa030131.47331410
43Morphine addiction_Homo sapiens_hsa050321.46764385
44Spliceosome_Homo sapiens_hsa030401.46636574
45Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.46261124
46mRNA surveillance pathway_Homo sapiens_hsa030151.42819326
47Circadian entrainment_Homo sapiens_hsa047131.41397508
48Non-homologous end-joining_Homo sapiens_hsa034501.37754147
49Peroxisome_Homo sapiens_hsa041461.36689661
50Cyanoamino acid metabolism_Homo sapiens_hsa004601.34785088
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.33669257
52Amphetamine addiction_Homo sapiens_hsa050311.32807433
53Purine metabolism_Homo sapiens_hsa002301.31324516
54Glycerolipid metabolism_Homo sapiens_hsa005611.31069485
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.29395376
56Serotonergic synapse_Homo sapiens_hsa047261.27432834
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.26426552
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.25868711
59Retinol metabolism_Homo sapiens_hsa008301.24700617
60Pyrimidine metabolism_Homo sapiens_hsa002401.23964065
61Steroid hormone biosynthesis_Homo sapiens_hsa001401.23663518
62Sulfur relay system_Homo sapiens_hsa041221.23195481
63Type I diabetes mellitus_Homo sapiens_hsa049401.22592285
64GABAergic synapse_Homo sapiens_hsa047271.20603746
65Long-term potentiation_Homo sapiens_hsa047201.18474598
66Chemical carcinogenesis_Homo sapiens_hsa052041.18305506
67Steroid biosynthesis_Homo sapiens_hsa001001.17965810
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.17599059
69Dopaminergic synapse_Homo sapiens_hsa047281.17329827
70Insulin secretion_Homo sapiens_hsa049111.09432950
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.09002287
72ABC transporters_Homo sapiens_hsa020101.06852133
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.05924731
74Rheumatoid arthritis_Homo sapiens_hsa053231.04452019
75Phototransduction_Homo sapiens_hsa047441.02482538
76Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.00899611
77Fat digestion and absorption_Homo sapiens_hsa049751.00835172
78Alzheimers disease_Homo sapiens_hsa050100.96784327
79Ether lipid metabolism_Homo sapiens_hsa005650.96746853
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.95879066
81Phagosome_Homo sapiens_hsa041450.94338737
82Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.91726356
83One carbon pool by folate_Homo sapiens_hsa006700.91367517
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.89157697
85Regulation of autophagy_Homo sapiens_hsa041400.87366300
86Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.86924305
87beta-Alanine metabolism_Homo sapiens_hsa004100.84198294
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.83853097
89Oocyte meiosis_Homo sapiens_hsa041140.82611042
90Glutamatergic synapse_Homo sapiens_hsa047240.80724235
91Cysteine and methionine metabolism_Homo sapiens_hsa002700.71740527
92Epstein-Barr virus infection_Homo sapiens_hsa051690.71449491
93Hedgehog signaling pathway_Homo sapiens_hsa043400.70957173
94Sulfur metabolism_Homo sapiens_hsa009200.69473289
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67783680
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.67141393
97Calcium signaling pathway_Homo sapiens_hsa040200.66149537
98Melanoma_Homo sapiens_hsa052180.65578224
99Long-term depression_Homo sapiens_hsa047300.65112066
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65056959
101Histidine metabolism_Homo sapiens_hsa003400.65030049
102Endometrial cancer_Homo sapiens_hsa052130.64001309
103Basal cell carcinoma_Homo sapiens_hsa052170.62605466
104Glycosaminoglycan degradation_Homo sapiens_hsa005310.59313298
105Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55990771
106Hippo signaling pathway_Homo sapiens_hsa043900.55630122
107Circadian rhythm_Homo sapiens_hsa047100.55323281
108Salivary secretion_Homo sapiens_hsa049700.54968378
109Cocaine addiction_Homo sapiens_hsa050300.54545168
110Metabolic pathways_Homo sapiens_hsa011000.53547100
111Cholinergic synapse_Homo sapiens_hsa047250.52780804
112PPAR signaling pathway_Homo sapiens_hsa033200.51882234
113Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50814891
114Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.50606172
115N-Glycan biosynthesis_Homo sapiens_hsa005100.50335678
116Thyroid cancer_Homo sapiens_hsa052160.49673016
117Ovarian steroidogenesis_Homo sapiens_hsa049130.46590758
118Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45235904
119ErbB signaling pathway_Homo sapiens_hsa040120.44500017
120Vascular smooth muscle contraction_Homo sapiens_hsa042700.44274319
121Alcoholism_Homo sapiens_hsa050340.43788394
122Renin secretion_Homo sapiens_hsa049240.41122696
123Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40846939
124TGF-beta signaling pathway_Homo sapiens_hsa043500.40636609
125Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40539822
126Arachidonic acid metabolism_Homo sapiens_hsa005900.40341479
127Mineral absorption_Homo sapiens_hsa049780.39552461
128Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.37993807
129Colorectal cancer_Homo sapiens_hsa052100.37643790
130Fatty acid degradation_Homo sapiens_hsa000710.36398321
131Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35899465
132Wnt signaling pathway_Homo sapiens_hsa043100.34067803
133Legionellosis_Homo sapiens_hsa051340.33998699
134cAMP signaling pathway_Homo sapiens_hsa040240.33015716
135Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.32413182
136Fructose and mannose metabolism_Homo sapiens_hsa000510.31582509
137Pyruvate metabolism_Homo sapiens_hsa006200.31572954
138Axon guidance_Homo sapiens_hsa043600.31564255
139Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.29774220
140FoxO signaling pathway_Homo sapiens_hsa040680.29230339
141Autoimmune thyroid disease_Homo sapiens_hsa053200.28652512
142Cardiac muscle contraction_Homo sapiens_hsa042600.28436672
143Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.28336857
144Fatty acid elongation_Homo sapiens_hsa000620.28156341
145Prostate cancer_Homo sapiens_hsa052150.26047380
146Phosphatidylinositol signaling system_Homo sapiens_hsa040700.25100008
147Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.24716256
148Influenza A_Homo sapiens_hsa051640.24338861
149Herpes simplex infection_Homo sapiens_hsa051680.24095636
150cGMP-PKG signaling pathway_Homo sapiens_hsa040220.23758386
151Melanogenesis_Homo sapiens_hsa049160.22894380
152MAPK signaling pathway_Homo sapiens_hsa040100.20196897
153Oxytocin signaling pathway_Homo sapiens_hsa049210.19861461
154Ras signaling pathway_Homo sapiens_hsa040140.19313495

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