NME8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with an N-terminal thioredoxin domain and three C-terminal nucleoside diphosphate kinase (NDK) domains, but the NDK domains are thought to be catalytically inactive. The sea urchin ortholog of this gene encodes a component of sperm outer dynein arms, and the protein is implicated in ciliary function. Mutations in this gene are implicated in primary ciliary dyskinesia type 6. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spermatid development (GO:0007286)9.50901830
2motile cilium assembly (GO:0044458)9.42040242
3reproduction (GO:0000003)9.38187413
4cilium movement (GO:0003341)9.30078614
5piRNA metabolic process (GO:0034587)9.07668684
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.49006130
7regulation of cilium movement (GO:0003352)8.44179806
8male meiosis (GO:0007140)8.19505487
9synaptonemal complex organization (GO:0070193)7.78093695
10single fertilization (GO:0007338)7.72279430
11synaptonemal complex assembly (GO:0007130)7.48168983
12sperm capacitation (GO:0048240)6.81182351
13fertilization (GO:0009566)6.64546999
14negative regulation of inclusion body assembly (GO:0090084)6.45618667
15* spermatogenesis (GO:0007283)6.38347899
16* male gamete generation (GO:0048232)6.36053515
17microtubule depolymerization (GO:0007019)6.00662114
18DNA methylation involved in gamete generation (GO:0043046)5.96688243
19positive regulation of gamma-delta T cell activation (GO:0046645)5.87778634
20* gamete generation (GO:0007276)5.84445041
21ventricular system development (GO:0021591)5.75012090
22neutrophil activation involved in immune response (GO:0002283)5.74922996
23organic cation transport (GO:0015695)5.59157540
24male meiosis I (GO:0007141)5.52041900
25modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.51004919
26positive regulation by organism of defense response of other organism involved in symbiotic interact5.51004919
27modulation by symbiont of host immune response (GO:0052553)5.51004919
28positive regulation by symbiont of host defense response (GO:0052509)5.51004919
29modulation by symbiont of host defense response (GO:0052031)5.51004919
30modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.51004919
31germ cell development (GO:0007281)5.41875217
32cellular process involved in reproduction in multicellular organism (GO:0022412)5.38585995
33regulation of inclusion body assembly (GO:0090083)5.32350793
34chromosome organization involved in meiosis (GO:0070192)5.22407303
35calcium ion-dependent exocytosis (GO:0017156)5.15070496
36response to peptidoglycan (GO:0032494)5.02587016
37macrophage activation involved in immune response (GO:0002281)5.00670842
38regulation of microtubule-based movement (GO:0060632)4.99395846
39detection of molecule of bacterial origin (GO:0032490)4.95806793
40seminiferous tubule development (GO:0072520)4.95087344
41cell recognition (GO:0008037)4.94868705
42detection of other organism (GO:0098543)4.91144549
43negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.87880876
44negative regulation of cell killing (GO:0031342)4.87880876
45antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.84563949
46regulation of B cell receptor signaling pathway (GO:0050855)4.79183749
47meiotic nuclear division (GO:0007126)4.74297929
48microtubule severing (GO:0051013)4.69957855
49microglial cell activation (GO:0001774)4.69115651
50* multicellular organismal reproductive process (GO:0048609)4.60331026
51detection of bacterium (GO:0016045)4.50199178
52meiosis I (GO:0007127)4.46362323
53glycerol ether metabolic process (GO:0006662)4.46157754
54detection of external biotic stimulus (GO:0098581)4.45514392
55immunoglobulin mediated immune response (GO:0016064)4.45039124
56negative regulation of interleukin-12 production (GO:0032695)4.36261024
57spermatid nucleus differentiation (GO:0007289)4.31227258
58antigen processing and presentation of endogenous antigen (GO:0019883)4.29453751
59left/right pattern formation (GO:0060972)4.28371619
60positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.23789902
61myeloid cell activation involved in immune response (GO:0002275)4.18595353
62response to host immune response (GO:0052572)4.17917055
63response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.17917055
64neutrophil activation (GO:0042119)4.16001026
65macrophage activation (GO:0042116)4.15098382
66ether metabolic process (GO:0018904)4.14026429
67positive regulation of mast cell activation (GO:0033005)4.14004035
68meiotic cell cycle (GO:0051321)4.12092854
69regulation of gamma-delta T cell activation (GO:0046643)4.10909810
70cellular extravasation (GO:0045123)4.10293873
71antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.08099360
72axoneme assembly (GO:0035082)4.04209393
73genitalia morphogenesis (GO:0035112)4.03370530
74monoubiquitinated protein deubiquitination (GO:0035520)4.01338405
75chaperone-mediated protein complex assembly (GO:0051131)4.00473788
76chromosome condensation (GO:0030261)3.99060609
77detection of biotic stimulus (GO:0009595)3.94303434
78positive regulation of B cell differentiation (GO:0045579)3.90764669
79positive regulation of mast cell degranulation (GO:0043306)3.90468950
80positive regulation of mast cell activation involved in immune response (GO:0033008)3.90468950
81granulocyte activation (GO:0036230)3.88088469
82protein localization to cilium (GO:0061512)3.87093650
83positive regulation of antigen processing and presentation (GO:0002579)3.84403918
84leukocyte aggregation (GO:0070486)3.84173650
85DNA packaging (GO:0006323)3.79049785
86regulation of mast cell degranulation (GO:0043304)3.78430234
87regulation of interferon-beta biosynthetic process (GO:0045357)3.77373570
88positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.72311500
89response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.71319586
90response to host (GO:0075136)3.71319586
91response to host defenses (GO:0052200)3.71319586
92* multicellular organismal development (GO:0007275)3.69229901
93regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.68250349
94protein polyglutamylation (GO:0018095)3.68061607
95regulation of mast cell activation (GO:0033003)3.65522938
96defense response to protozoan (GO:0042832)3.62427558
97respiratory burst (GO:0045730)3.62135023
98antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.61112213
99regulation of mast cell activation involved in immune response (GO:0033006)3.58837320
100regulation of antigen processing and presentation (GO:0002577)3.56802702
101negative regulation of lymphocyte mediated immunity (GO:0002707)3.51445997
102interferon-gamma-mediated signaling pathway (GO:0060333)3.50833210
103B cell mediated immunity (GO:0019724)3.48055564
104leukocyte migration involved in inflammatory response (GO:0002523)3.44994223
105intraciliary transport (GO:0042073)3.42548459
106T-helper 1 type immune response (GO:0042088)3.42018518
107regulation of B cell differentiation (GO:0045577)3.41744665
108negative regulation of T cell mediated immunity (GO:0002710)3.41742661
109regulation of gamma-delta T cell differentiation (GO:0045586)3.36643158
110positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.33901998
111neutrophil mediated immunity (GO:0002446)3.31697420
112microtubule-based movement (GO:0007018)3.31323276
113response to protozoan (GO:0001562)3.31094498
114sequestering of actin monomers (GO:0042989)3.30018440
115lactate metabolic process (GO:0006089)3.29705952
116regulation of myeloid leukocyte mediated immunity (GO:0002886)3.26369496
117gene silencing by RNA (GO:0031047)3.24585231
118positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.24452263
119positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.24023905
120alditol metabolic process (GO:0019400)3.22509197
121B cell receptor signaling pathway (GO:0050853)3.21745331
122protein K11-linked deubiquitination (GO:0035871)3.21607319
123positive regulation of interleukin-1 beta secretion (GO:0050718)3.21341404
124response to type I interferon (GO:0034340)3.19354759
125cilium organization (GO:0044782)3.18195796
126production of molecular mediator involved in inflammatory response (GO:0002532)3.18160120
127cellular response to type I interferon (GO:0071357)3.17557982
128type I interferon signaling pathway (GO:0060337)3.17557982
129polyol catabolic process (GO:0046174)3.16780402
130antigen processing and presentation via MHC class Ib (GO:0002475)3.14882045
131synapsis (GO:0007129)3.13737950
132glycolytic process (GO:0006096)3.12780101
133myeloid leukocyte activation (GO:0002274)3.12214231
134negative regulation of leukocyte mediated immunity (GO:0002704)3.12195059
135meiotic cell cycle process (GO:1903046)3.11047465
136protein refolding (GO:0042026)3.10864424
137negative regulation of organelle assembly (GO:1902116)3.09668968
138microtubule polymerization or depolymerization (GO:0031109)3.08742859
139regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.08626127
140regulation of leukocyte degranulation (GO:0043300)3.06967258
141regulation of spindle checkpoint (GO:0090231)3.06878765
142negative regulation of erythrocyte differentiation (GO:0045647)3.06629786
143lipopolysaccharide-mediated signaling pathway (GO:0031663)3.06477840
144regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.06438921
145regulation of dendritic cell antigen processing and presentation (GO:0002604)3.06233807
146leukocyte degranulation (GO:0043299)3.05762895
147carnitine transport (GO:0015879)3.04733437
148amino-acid betaine transport (GO:0015838)3.04733437
149response to muramyl dipeptide (GO:0032495)3.04221380
150mitotic sister chromatid cohesion (GO:0007064)3.03779697
151regulation of tolerance induction (GO:0002643)3.02547167
152cellular component assembly involved in morphogenesis (GO:0010927)3.02393250
153cilium assembly (GO:0042384)3.01222918
154positive thymic T cell selection (GO:0045059)3.01052190
155cilium morphogenesis (GO:0060271)3.00804313
156single strand break repair (GO:0000012)3.00547367
157positive regulation of interleukin-1 secretion (GO:0050716)3.00006407
158regulation of alpha-beta T cell proliferation (GO:0046640)2.99319029
159regulation of interleukin-1 beta secretion (GO:0050706)2.97581303
160carnitine transmembrane transport (GO:1902603)2.95324942
161histamine secretion (GO:0001821)2.95079704
162negative regulation of cytokine production involved in immune response (GO:0002719)2.94853332
163positive regulation of interleukin-10 production (GO:0032733)2.93644579
164positive regulation of interferon-alpha production (GO:0032727)2.93541239
165pinocytosis (GO:0006907)2.92293934
166sexual reproduction (GO:0019953)2.90743113
167regulation of interferon-alpha production (GO:0032647)2.89880542
168regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.89867722
169regulation of T cell tolerance induction (GO:0002664)2.89783340
170regulation of T-helper 2 cell differentiation (GO:0045628)2.89429883
171positive regulation of type 2 immune response (GO:0002830)2.87029374
172myeloid leukocyte mediated immunity (GO:0002444)2.85865886
173negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.84711944
174nucleus organization (GO:0006997)2.80108168
175glycerol metabolic process (GO:0006071)2.78867497
176regulation of meiosis I (GO:0060631)2.76431106
177regulation of centriole replication (GO:0046599)2.69560727
178centriole assembly (GO:0098534)2.60046950
179nuclear pore complex assembly (GO:0051292)2.57829113
180regulation of protein polyubiquitination (GO:1902914)2.52318909
181gene silencing (GO:0016458)2.52058437
182* nucleoside diphosphate phosphorylation (GO:0006165)2.52026153
183left/right axis specification (GO:0070986)2.47436759
184peptidyl-glutamic acid modification (GO:0018200)2.46897980
185interferon-gamma secretion (GO:0072643)2.45606878
186centriole replication (GO:0007099)2.40580448
187fusion of sperm to egg plasma membrane (GO:0007342)14.0550061
188sperm motility (GO:0030317)13.3914209
189cilium or flagellum-dependent cell motility (GO:0001539)12.5352158
190acrosome assembly (GO:0001675)11.9984667
191sperm-egg recognition (GO:0035036)11.4019621
192multicellular organism reproduction (GO:0032504)11.2317149
193acrosome reaction (GO:0007340)11.1854649
194axonemal dynein complex assembly (GO:0070286)10.8959197
195cell wall macromolecule metabolic process (GO:0044036)10.8609209
196cell wall macromolecule catabolic process (GO:0016998)10.8609209
197plasma membrane fusion (GO:0045026)10.7044558
198epithelial cilium movement (GO:0003351)10.6118152
199binding of sperm to zona pellucida (GO:0007339)10.5581714
200cell-cell recognition (GO:0009988)10.1949515

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.69923606
2EZH2_22144423_ChIP-Seq_EOC_Human5.19398990
3IRF8_21731497_ChIP-ChIP_J774_Mouse5.09765939
4BP1_19119308_ChIP-ChIP_Hs578T_Human5.05577199
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.48835573
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.82632386
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.67570302
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.65726722
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.58017124
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.40412459
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.35101728
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.33372217
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.18863247
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.98086736
15SCL_19346495_ChIP-Seq_HPC-7_Human2.92839346
16SPI1_23547873_ChIP-Seq_NB4_Human2.92402912
17NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.87158581
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.82586305
19PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.75633851
20RUNX_20019798_ChIP-Seq_JUKART_Human2.69724741
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.62293299
22MYB_26560356_Chip-Seq_TH2_Human2.57710926
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.55205995
24SPI1_23127762_ChIP-Seq_K562_Human2.50760117
25VDR_24763502_ChIP-Seq_THP-1_Human2.41518188
26FLI1_27457419_Chip-Seq_LIVER_Mouse2.38142418
27RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.32988368
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.29067101
29CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.21293816
30Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.20911338
31ZNF274_21170338_ChIP-Seq_K562_Hela2.16193620
32VDR_21846776_ChIP-Seq_THP-1_Human2.14284024
33VDR_24787735_ChIP-Seq_THP-1_Human2.14229657
34EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.10860513
35STAT6_21828071_ChIP-Seq_BEAS2B_Human2.10727591
36STAT4_19710469_ChIP-ChIP_TH1__Mouse2.09212383
37LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.08394855
38VDR_22108803_ChIP-Seq_LS180_Human2.07221521
39MYB_26560356_Chip-Seq_TH1_Human2.02468136
40SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.02176012
41CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.01519201
42MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.1905035
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.95913651
44MAF_26560356_Chip-Seq_TH1_Human1.93534985
45FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.93467116
46BRD4_27068464_Chip-Seq_AML-cells_Mouse1.91935199
47GATA1_26923725_Chip-Seq_HPCs_Mouse1.91081723
48RUNX1_22412390_ChIP-Seq_EML_Mouse1.90134216
49NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.83836346
50LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.82070119
51E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.79853502
52GATA3_27048872_Chip-Seq_THYMUS_Human1.78453802
53RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.75215508
54KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.74835704
55SMAD_19615063_ChIP-ChIP_OVARY_Human1.73022842
56ELK4_26923725_Chip-Seq_MESODERM_Mouse1.70717728
57TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.70563172
58GATA3_26560356_Chip-Seq_TH2_Human1.69957671
59STAT1_17558387_ChIP-Seq_HELA_Human1.65098237
60VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.64425189
61RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.64136618
62MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.62513261
63UTX_26944678_Chip-Seq_JUKART_Human1.56290224
64CBX2_27304074_Chip-Seq_ESCs_Mouse1.56032182
65GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.53905458
66ELF1_17652178_ChIP-ChIP_JURKAT_Human1.53743626
67WDR5_24793694_ChIP-Seq_LNCAP_Human1.53339293
68FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.51713065
69SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.51468693
70PCGF2_27294783_Chip-Seq_NPCs_Mouse1.51414098
71MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.50703734
72GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49374751
73NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.49013338
74FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47103680
75SOX2_22085726_ChIP-Seq_NPCs_Mouse1.46622166
76CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.45805081
77TAL1_26923725_Chip-Seq_HPCs_Mouse1.45482704
78NFE2_27457419_Chip-Seq_LIVER_Mouse1.43053249
79KDM2B_26808549_Chip-Seq_REH_Human1.42530960
80CBP_20019798_ChIP-Seq_JUKART_Human1.40903930
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40903930
82KAP1_22055183_ChIP-Seq_ESCs_Mouse1.39965178
83GATA1_19941827_ChIP-Seq_MEL_Mouse1.37763848
84PU_27001747_Chip-Seq_BMDM_Mouse1.35433094
85SUZ12_27294783_Chip-Seq_NPCs_Mouse1.35122797
86GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.34427016
87GATA3_21867929_ChIP-Seq_CD8_Mouse1.33838772
88ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.32378412
89GATA2_22383799_ChIP-Seq_G1ME_Mouse1.32152995
90VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.32127158
91ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.31701365
92TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30988571
93REST_21632747_ChIP-Seq_MESCs_Mouse1.29185137
94GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28329391
95SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27227129
96STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.25679172
97FLI1_21867929_ChIP-Seq_TH2_Mouse1.25370032
98MAF_26560356_Chip-Seq_TH2_Human1.24973686
99GATA2_21666600_ChIP-Seq_HMVEC_Human1.24954964
100LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.24129216
101GATA3_21867929_ChIP-Seq_TH1_Mouse1.23370762
102CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22179290
103POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22067388
104TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22067388
105PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21603887
106P53_21459846_ChIP-Seq_SAOS-2_Human1.21069052
107CTBP2_25329375_ChIP-Seq_LNCAP_Human1.19819527
108CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19270424
109SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.19213304
110STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.19000238
111PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.17719197
112TAF15_26573619_Chip-Seq_HEK293_Human1.16663468
113CRX_20693478_ChIP-Seq_RETINA_Mouse1.16076570
114TCF7_22412390_ChIP-Seq_EML_Mouse1.15870523
115TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.14688985
116RNF2_27304074_Chip-Seq_NSC_Mouse1.14198900
117EGR1_19374776_ChIP-ChIP_THP-1_Human1.13862126
118FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.13620639
119NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.13572132
120NANOG_18555785_Chip-Seq_ESCs_Mouse1.13066021
121SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.12662678
122EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.11269093
123RAD21_21589869_ChIP-Seq_MESCs_Mouse1.10722390
124TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10632336
125GF1_26923725_Chip-Seq_HPCs_Mouse1.09692000
126CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09532821
127CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08291711
128PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.06104225
129MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.06033233
130OCT4_18555785_Chip-Seq_ESCs_Mouse1.05786826
131EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05213237
132MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03904182
133GATA1_19941826_ChIP-Seq_K562_Human1.03796701
134PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03660546
135ZFP57_27257070_Chip-Seq_ESCs_Mouse1.03063918
136ERG_20517297_ChIP-Seq_VCAP_Human1.02436724
137PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01054705
138P53_22387025_ChIP-Seq_ESCs_Mouse1.00830845
139EZH2_27294783_Chip-Seq_NPCs_Mouse0.99346059
140SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98535578
141CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98481748
142SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98454957
143MYC_22102868_ChIP-Seq_BL_Human0.98119658
144CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97032742
145OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96927319
146SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96820921
147GATA1_22383799_ChIP-Seq_G1ME_Mouse0.96715225
148RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.96280315
149PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.96238092
150P300_18555785_Chip-Seq_ESCs_Mouse0.95793192
151SPI1_26923725_Chip-Seq_HPCs_Mouse0.95728444
152RUNX1_26923725_Chip-Seq_HPCs_Mouse0.95071418
153CMYC_18555785_Chip-Seq_ESCs_Mouse0.94151514
154EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.93834386
155EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.92786969
156MYC_27129775_Chip-Seq_CORNEA_Mouse0.92524622
157PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92155010
158KLF4_18555785_Chip-Seq_ESCs_Mouse0.92019772
159ESRRB_18555785_Chip-Seq_ESCs_Mouse0.91116246
160SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91095658
161ESET_19884257_ChIP-Seq_ESCs_Mouse0.91020704
162CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.90499639
163RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.90486649
164IKZF1_21737484_ChIP-ChIP_HCT116_Human0.90179420
165SMAD4_21741376_ChIP-Seq_EPCs_Human0.89785865
166GATA1_22025678_ChIP-Seq_K562_Human0.89629728
167SOX9_26525672_Chip-Seq_HEART_Mouse0.89124738
168GF1B_26923725_Chip-Seq_HPCs_Mouse0.88104237
169KDM2B_26808549_Chip-Seq_SUP-B15_Human0.87937145
170NFYB_21822215_ChIP-Seq_K562_Human0.87453128
171GATA2_19941826_ChIP-Seq_K562_Human0.87218075
172YY1_22570637_ChIP-Seq_MALME-3M_Human0.86907128
173KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.86613752
174KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.86613752
175KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.86613752
176STAT3_18555785_Chip-Seq_ESCs_Mouse0.85993205
177SUZ12_18555785_Chip-Seq_ESCs_Mouse0.85921148
178STAT1_20625510_ChIP-Seq_HELA_Human0.85508792
179GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85190242
180RXRA_24833708_ChIP-Seq_LIVER_Mouse0.84856052
181PU1_27457419_Chip-Seq_LIVER_Mouse0.83947691
182LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.83841737
183SMRT_27268052_Chip-Seq_Bcells_Human0.83840649
184RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78772023
185SPI1_20517297_ChIP-Seq_HL60_Human0.78302008
186BCL6_27268052_Chip-Seq_Bcells_Human0.77960287
187KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.76244861
188GATA1_19941827_ChIP-Seq_MEL86_Mouse0.75601069
189GATA3_26560356_Chip-Seq_TH1_Human0.75349433
190PU.1_20513432_ChIP-Seq_Bcells_Mouse0.74712777
191KDM2B_26808549_Chip-Seq_DND41_Human0.74255567
192KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.73499059
193BCOR_27268052_Chip-Seq_Bcells_Human0.72968279
194RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.72013683
195CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.69089546
196RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.68731889

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.09372082
2MP0001929_abnormal_gametogenesis5.57938482
3MP0003724_increased_susceptibility_to5.06394567
4MP0008877_abnormal_DNA_methylation5.05130418
5MP0001835_abnormal_antigen_presentation4.29901694
6MP0003303_peritoneal_inflammation3.91134250
7MP0003436_decreased_susceptibility_to3.80294823
8MP0002210_abnormal_sex_determination3.61383432
9MP0002161_abnormal_fertility/fecundity3.29292134
10MP0002419_abnormal_innate_immunity3.21297161
11MP0006082_CNS_inflammation3.10740398
12MP0005671_abnormal_response_to3.09739200
13MP0001145_abnormal_male_reproductive3.02991233
14MP0009785_altered_susceptibility_to2.93104475
15MP0002148_abnormal_hypersensitivity_rea2.89959840
16MP0005000_abnormal_immune_tolerance2.86784184
17MP0005025_abnormal_response_to2.83297819
18MP0001800_abnormal_humoral_immune2.82693013
19MP0002653_abnormal_ependyma_morphology2.75533705
20MP0000653_abnormal_sex_gland2.62844583
21MP0002723_abnormal_immune_serum2.61245051
22MP0002452_abnormal_antigen_presenting2.59708684
23MP0003172_abnormal_lysosome_physiology2.55862002
24MP0005670_abnormal_white_adipose2.52236368
25MP0005387_immune_system_phenotype2.50038047
26MP0001790_abnormal_immune_system2.50038047
27MP0005464_abnormal_platelet_physiology2.47648800
28MP0001819_abnormal_immune_cell2.45194620
29MP0002420_abnormal_adaptive_immunity2.43612008
30MP0003183_abnormal_peptide_metabolism2.34250597
31MP0000685_abnormal_immune_system2.32979599
32MP0005623_abnormal_meninges_morphology2.13458395
33MP0001533_abnormal_skeleton_physiology2.12507283
34MP0005410_abnormal_fertilization15.8609366
35MP0003191_abnormal_cellular_cholesterol1.93952468
36MP0003300_gastrointestinal_ulcer1.92977394
37MP0002160_abnormal_reproductive_system1.87900781
38MP0001845_abnormal_inflammatory_respons1.85085585
39MP0009764_decreased_sensitivity_to1.81764280
40MP0008260_abnormal_autophagy1.81667131
41MP0000716_abnormal_immune_system1.79547723
42MP0002398_abnormal_bone_marrow1.76219788
43MP0010155_abnormal_intestine_physiology1.73047023
44MP0003763_abnormal_thymus_physiology1.70388043
45MP0003828_pulmonary_edema1.64365175
46MP0002132_abnormal_respiratory_system1.64223309
47MP0003075_altered_response_to1.59475080
48MP0008469_abnormal_protein_level1.57122062
49MP0005451_abnormal_body_composition1.56257864
50MP0008004_abnormal_stomach_pH1.56104821
51MP0000689_abnormal_spleen_morphology1.54205951
52MP0002396_abnormal_hematopoietic_system1.45653784
53MP0002722_abnormal_immune_system1.45478475
54MP0000465_gastrointestinal_hemorrhage1.43322545
55MP0002282_abnormal_trachea_morphology1.42897893
56MP0002429_abnormal_blood_cell1.41565461
57MP0005058_abnormal_lysosome_morphology1.41478213
58MP0006054_spinal_hemorrhage1.36890949
59MP0000858_altered_metastatic_potential1.31760664
60MP0002277_abnormal_respiratory_mucosa1.30892409
61MP0009333_abnormal_splenocyte_physiolog1.28111865
62MP0003646_muscle_fatigue1.26741421
63MP0004947_skin_inflammation1.25430240
64MP0002998_abnormal_bone_remodeling1.20129575
65MP0008995_early_reproductive_senescence1.18614309
66MP0008057_abnormal_DNA_replication1.15502447
67MP0001765_abnormal_ion_homeostasis1.15261538
68MP0005647_abnormal_sex_gland1.15028085
69MP0003866_abnormal_defecation1.13836410
70MP0004883_abnormal_blood_vessel1.12636555
71MP0000343_altered_response_to1.11263363
72MP0002166_altered_tumor_susceptibility1.09813400
73MP0005166_decreased_susceptibility_to1.07622456
74MP0000703_abnormal_thymus_morphology1.07538094
75MP0001853_heart_inflammation1.07154836
76MP0003690_abnormal_glial_cell1.06590894
77MP0005310_abnormal_salivary_gland1.04408286
78MP0001984_abnormal_olfaction1.02863336
79MP0004510_myositis1.02366068
80MP0009046_muscle_twitch1.01822049
81MP0008058_abnormal_DNA_repair1.01619244
82MP0002138_abnormal_hepatobiliary_system1.00597425
83MP0003806_abnormal_nucleotide_metabolis0.99439588
84MP0004233_abnormal_muscle_weight0.99069286
85MP0009840_abnormal_foam_cell0.98665601
86MP0005164_abnormal_response_to0.97566380
87MP0005075_abnormal_melanosome_morpholog0.96593138
88MP0001663_abnormal_digestive_system0.95413545
89MP0005389_reproductive_system_phenotype0.93653875
90MP0009763_increased_sensitivity_to0.93580524
91MP0003448_altered_tumor_morphology0.90164267
92MP0004381_abnormal_hair_follicle0.87287025
93MP0005390_skeleton_phenotype0.84546370
94MP0003011_delayed_dark_adaptation0.83637976
95MP0002933_joint_inflammation0.78936934
96MP0009765_abnormal_xenobiotic_induced0.75558548
97MP0000015_abnormal_ear_pigmentation0.71261299
98MP0010094_abnormal_chromosome_stability0.71060503
99MP0002006_tumorigenesis0.70769001
100MP0005319_abnormal_enzyme/_coenzyme0.69579600
101MP0003786_premature_aging0.66903221
102MP0003656_abnormal_erythrocyte_physiolo0.65560340
103MP0002234_abnormal_pharynx_morphology0.65272593
104MP0000249_abnormal_blood_vessel0.63273830
105MP0001873_stomach_inflammation0.62903868
106MP0003878_abnormal_ear_physiology0.62447129
107MP0005377_hearing/vestibular/ear_phenot0.62447129
108MP0005535_abnormal_body_temperature0.61294316
109MP0005084_abnormal_gallbladder_morpholo0.60956083
110MP0003115_abnormal_respiratory_system0.60707451
111MP0003795_abnormal_bone_structure0.60622360
112MP0005174_abnormal_tail_pigmentation0.60024981
113MP0003195_calcinosis0.58629498
114MP0005636_abnormal_mineral_homeostasis0.58358434
115MP0005666_abnormal_adipose_tissue0.56916152
116MP0005083_abnormal_biliary_tract0.56808532
117MP0005167_abnormal_blood-brain_barrier0.55327574
118MP0000569_abnormal_digit_pigmentation0.54143902
119MP0005397_hematopoietic_system_phenotyp0.54142389
120MP0001545_abnormal_hematopoietic_system0.54142389
121MP0002009_preneoplasia0.53291945
122MP0008007_abnormal_cellular_replicative0.50937977
123MP0000358_abnormal_cell_content/0.49650199
124MP0004036_abnormal_muscle_relaxation0.49622777
125MP0005551_abnormal_eye_electrophysiolog0.48392595
126MP0009278_abnormal_bone_marrow0.47950753
127MP0005253_abnormal_eye_physiology0.47828617
128MP0003329_amyloid_beta_deposits0.47700593
129MP0005381_digestive/alimentary_phenotyp0.47023964
130MP0008873_increased_physiological_sensi0.46428184
131MP0000920_abnormal_myelination0.46272102
132MP0002928_abnormal_bile_duct0.45160466
133MP0002019_abnormal_tumor_incidence0.44773318
134MP0003950_abnormal_plasma_membrane0.44595086
135MP0003699_abnormal_female_reproductive0.44446340
136MP0001324_abnormal_eye_pigmentation0.44205430
137MP0005423_abnormal_somatic_nervous0.43518985
138MP0001727_abnormal_embryo_implantation0.43419641
139MP0002269_muscular_atrophy0.41076444
140MP0001986_abnormal_taste_sensitivity0.39259989
141MP0004134_abnormal_chest_morphology0.39042298
142MP0002971_abnormal_brown_adipose0.38848996
143MP0001293_anophthalmia0.38465627
144MP0009115_abnormal_fat_cell0.37965580
145MP0005391_vision/eye_phenotype0.36234364
146MP0003111_abnormal_nucleus_morphology0.35441766
147MP0001764_abnormal_homeostasis0.32819667
148MP0003879_abnormal_hair_cell0.32444233
149MP0004808_abnormal_hematopoietic_stem0.31939875
150MP0004019_abnormal_vitamin_homeostasis0.30883819
151MP0001119_abnormal_female_reproductive0.30796882
152MP0004811_abnormal_neuron_physiology0.29249409
153MP0006036_abnormal_mitochondrial_physio0.28300756
154MP0003633_abnormal_nervous_system0.28180852
155MP0003861_abnormal_nervous_system0.27365724
156MP0000534_abnormal_ureter_morphology0.25962178
157MP0001440_abnormal_grooming_behavior0.25865239
158MP0000751_myopathy0.25822664
159MP0001849_ear_inflammation0.25544702
160MP0002152_abnormal_brain_morphology0.25226030
161MP0010307_abnormal_tumor_latency0.25099204
162MP0002736_abnormal_nociception_after0.24216641
163MP0006072_abnormal_retinal_apoptosis0.23844642
164MP0008961_abnormal_basal_metabolism0.21417876
165MP0003631_nervous_system_phenotype0.21392987
166MP0001730_embryonic_growth_arrest0.20961964
167MP0004133_heterotaxia0.20418833
168MP0004270_analgesia0.20190395
169MP0002102_abnormal_ear_morphology0.20142980
170MP0003948_abnormal_gas_homeostasis0.19977061
171MP0002229_neurodegeneration0.19734684
172MP0003942_abnormal_urinary_system0.19134056
173MP0002092_abnormal_eye_morphology0.18785176
174MP0003045_fibrosis0.17831854
175MP0000604_amyloidosis0.17802953
176MP0002169_no_abnormal_phenotype0.17686818
177MP0002873_normal_phenotype0.17467709
178MP0004742_abnormal_vestibular_system0.17283687
179MP0002139_abnormal_hepatobiliary_system0.16989590
180MP0001851_eye_inflammation0.16472223
181MP0005375_adipose_tissue_phenotype0.16278204
182MP0006035_abnormal_mitochondrial_morpho0.16195813
183MP0000313_abnormal_cell_death0.16088119
184MP0002295_abnormal_pulmonary_circulatio0.14869669
185MP0002405_respiratory_system_inflammati0.14407274
186MP0002572_abnormal_emotion/affect_behav0.14239648
187MP0002133_abnormal_respiratory_system0.13497604
188MP0005388_respiratory_system_phenotype0.13497604
189MP0005195_abnormal_posterior_eye0.13334586
190MP0002970_abnormal_white_adipose0.13121263

Predicted human phenotypes

RankGene SetZ-score
1* Abnormal respiratory motile cilium physiology (HP:0012261)9.43995943
2Rhinitis (HP:0012384)8.77202036
3* Abnormal respiratory epithelium morphology (HP:0012253)8.27560201
4* Abnormal respiratory motile cilium morphology (HP:0005938)8.27560201
5Chronic bronchitis (HP:0004469)8.08125738
6* Abnormal ciliary motility (HP:0012262)7.04360191
7Infertility (HP:0000789)7.01989694
8Nasal polyposis (HP:0100582)6.82625736
9Recurrent bacterial skin infections (HP:0005406)6.23240715
10Recurrent abscess formation (HP:0002722)6.09323541
11Myositis (HP:0100614)5.68101950
12Abnormality of the nasal mucosa (HP:0000433)5.60734389
13Eczematoid dermatitis (HP:0000976)5.39534938
14Orchitis (HP:0100796)5.08641845
15Bronchiectasis (HP:0002110)5.03816214
16Retrobulbar optic neuritis (HP:0100654)4.97722210
17Optic neuritis (HP:0100653)4.97722210
18Abnormality of macrophages (HP:0004311)4.93582172
19Bronchitis (HP:0012387)4.87987136
20Nephronophthisis (HP:0000090)4.77939829
21Chronic obstructive pulmonary disease (HP:0006510)4.71639759
22Obstructive lung disease (HP:0006536)4.71639759
23Stomatitis (HP:0010280)4.53654815
24Elevated erythrocyte sedimentation rate (HP:0003565)4.29603717
25Male infertility (HP:0003251)4.24120761
26Recurrent gram-negative bacterial infections (HP:0005420)4.13202526
27Meningitis (HP:0001287)4.06748396
28Recurrent fungal infections (HP:0002841)4.03217604
29Gastrointestinal infarctions (HP:0005244)4.01612000
30Keratoconjunctivitis sicca (HP:0001097)4.00324950
31Recurrent skin infections (HP:0001581)3.96305243
32Mediastinal lymphadenopathy (HP:0100721)3.96221221
33Encephalitis (HP:0002383)3.78702782
34Hemoptysis (HP:0002105)3.73240438
35Keratoconjunctivitis (HP:0001096)3.68825748
36Vasculitis (HP:0002633)3.64419287
37Abnormality of the renal medulla (HP:0100957)3.63906322
38Recurrent otitis media (HP:0000403)3.60319026
39Chest pain (HP:0100749)3.53854398
40Recurrent cutaneous fungal infections (HP:0011370)3.40643062
41Chronic mucocutaneous candidiasis (HP:0002728)3.40643062
42Abnormal delayed hypersensitivity skin test (HP:0002963)3.39372950
43Spontaneous hematomas (HP:0007420)3.37799858
44Abnormal spermatogenesis (HP:0008669)3.35294515
45Arterial thrombosis (HP:0004420)3.28486952
46Prolonged bleeding time (HP:0003010)3.24467520
47Gingival bleeding (HP:0000225)3.20508231
48Pulmonary infiltrates (HP:0002113)3.19601167
49Gingivitis (HP:0000230)3.18809616
50Tubulointerstitial nephritis (HP:0001970)3.13675251
51Panhypogammaglobulinemia (HP:0003139)3.04663990
52Urticaria (HP:0001025)3.04511916
53Epistaxis (HP:0000421)3.01707517
54Recurrent viral infections (HP:0004429)2.95117808
55T lymphocytopenia (HP:0005403)2.90088354
56Gonadotropin excess (HP:0000837)2.88433037
57Increased cerebral lipofuscin (HP:0011813)2.88065560
58Tubular atrophy (HP:0000092)2.87546594
59Anorexia (HP:0002039)2.83239721
60Abnormality of T cell number (HP:0011839)2.82289065
61Abnormality of midbrain morphology (HP:0002418)2.80174536
62Molar tooth sign on MRI (HP:0002419)2.80174536
63Pulmonary embolism (HP:0002204)2.79589480
64Abnormality of the pleura (HP:0002103)2.78531948
65Loss of speech (HP:0002371)2.77614267
66Gangrene (HP:0100758)2.76373872
67Abnormality of the prostate (HP:0008775)2.74979929
68Recurrent bronchitis (HP:0002837)2.74561401
69Absent rod-and cone-mediated responses on ERG (HP:0007688)2.73698581
70Amyloidosis (HP:0011034)2.72836989
71Increased IgE level (HP:0003212)2.68151816
72Leukocytosis (HP:0001974)2.65231326
73Abnormality of the lower motor neuron (HP:0002366)2.64677460
74Glomerulopathy (HP:0100820)2.63359765
75Tubulointerstitial abnormality (HP:0001969)2.62592727
76Abnormality of glycolipid metabolism (HP:0010969)2.60220837
77Abnormality of liposaccharide metabolism (HP:0010968)2.60220837
78Abnormality of glycosphingolipid metabolism (HP:0004343)2.60220837
79Increased neuronal autofluorescent lipopigment (HP:0002074)2.55730736
80Cellulitis (HP:0100658)2.55707779
81Medial flaring of the eyebrow (HP:0010747)2.54038274
82Petechiae (HP:0000967)2.51443494
83Hypochromic microcytic anemia (HP:0004840)2.51298256
84Chronic otitis media (HP:0000389)2.50610678
85Pustule (HP:0200039)2.47394952
86Abnormality of T cells (HP:0002843)2.42873570
87Inflammation of the large intestine (HP:0002037)2.41980576
88* Recurrent sinusitis (HP:0011108)2.40948425
89Autoimmune thrombocytopenia (HP:0001973)2.40214449
90Vertigo (HP:0002321)2.39706168
91Episodic fever (HP:0001954)2.37178980
92Peritonitis (HP:0002586)2.36942007
93Impulsivity (HP:0100710)2.36370778
94Amaurosis fugax (HP:0100576)2.31907882
95Gastrointestinal inflammation (HP:0004386)2.30556408
96Hypochromic anemia (HP:0001931)2.27189644
97Granulocytopenia (HP:0001913)2.24323685
98Fibular hypoplasia (HP:0003038)2.22094264
99Osteomyelitis (HP:0002754)2.21498771
100Thrombophlebitis (HP:0004418)2.21036372
101Azoospermia (HP:0000027)2.19381544
102Keratitis (HP:0000491)2.16910526
103Postaxial foot polydactyly (HP:0001830)2.16099160
104Stage 5 chronic kidney disease (HP:0003774)2.14000555
105Amyotrophic lateral sclerosis (HP:0007354)2.13815803
106Colitis (HP:0002583)2.12418701
107Purpura (HP:0000979)2.11627877
108Abnormality of the renal cortex (HP:0011035)2.11387759
109Polyneuropathy (HP:0001271)2.11152913
110Joint swelling (HP:0001386)2.09658380
111Skin rash (HP:0000988)2.09603999
112Abnormality of the peritoneum (HP:0002585)2.09512331
113Dysostosis multiplex (HP:0000943)2.09084506
114Disinhibition (HP:0000734)2.08388312
115Abnormality of T cell physiology (HP:0011840)2.07381965
116Tubulointerstitial fibrosis (HP:0005576)2.06895267
117Agammaglobulinemia (HP:0004432)2.06672751
118Increased IgM level (HP:0003496)2.05736352
119Abnormality of the pericardium (HP:0001697)2.04192796
120Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.00708019
121Respiratory insufficiency due to defective ciliary clearance (HP:0200073)14.7891418
122* Dynein arm defect of respiratory motile cilia (HP:0012255)11.5342574
123* Absent/shortened dynein arms (HP:0200106)11.5342574
124IgM deficiency (HP:0002850)1.99352136
125Autoimmune hemolytic anemia (HP:0001890)1.99332558
126Eosinophilia (HP:0001880)1.98573541
127Sepsis (HP:0100806)1.98562746
128Abnormal gallbladder physiology (HP:0012438)1.96998329
129Cholecystitis (HP:0001082)1.96998329
130Viral hepatitis (HP:0006562)1.96470739
131Congenital hepatic fibrosis (HP:0002612)1.95416474
132Restrictive lung disease (HP:0002091)1.93985342
133Polydipsia (HP:0001959)1.89932162
134Abnormal drinking behavior (HP:0030082)1.89932162
135Recurrent pneumonia (HP:0006532)1.89276784
136Hypoplasia of the capital femoral epiphysis (HP:0003090)1.88213566
137Microcytic anemia (HP:0001935)1.87774756
138Vacuolated lymphocytes (HP:0001922)1.86361949
139Abnormality of the dental root (HP:0006486)1.86079296
140Taurodontia (HP:0000679)1.86079296
141Abnormality of permanent molar morphology (HP:0011071)1.86079296
142Skin ulcer (HP:0200042)1.85939487
143Paresthesia (HP:0003401)1.84041357
144Systemic lupus erythematosus (HP:0002725)1.83689300
145Spastic tetraparesis (HP:0001285)1.80615421
146Oculomotor apraxia (HP:0000657)1.80433503
147Short ribs (HP:0000773)1.78664539
148Abnormality of dentin (HP:0010299)1.78469449
149Absent frontal sinuses (HP:0002688)1.78350978
150Dyschromatopsia (HP:0007641)1.77077376
151Abnormality of renal excretion (HP:0011036)1.72817202
152Abnormality of molar morphology (HP:0011070)1.72492125
153Abnormality of molar (HP:0011077)1.72492125
154Abnormality of the dental pulp (HP:0006479)1.71388562
155Impaired proprioception (HP:0010831)1.66624775
156Cystic liver disease (HP:0006706)1.65361277
157J-shaped sella turcica (HP:0002680)1.64739612
158Chronic sinusitis (HP:0011109)1.63486552
159Facial cleft (HP:0002006)1.63041637
160Pancreatic fibrosis (HP:0100732)1.62333088
161Abnormal biliary tract physiology (HP:0012439)1.61799491
162Bile duct proliferation (HP:0001408)1.61799491
163Postaxial hand polydactyly (HP:0001162)1.61551072
164Microglossia (HP:0000171)1.61452645
165Renal dysplasia (HP:0000110)1.60536729
166Heterotopia (HP:0002282)1.58350728
167Decreased central vision (HP:0007663)1.54603672
168Choroideremia (HP:0001139)1.54104995
169Bell-shaped thorax (HP:0001591)1.53224751
170Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.51431550
171Aplasia/Hypoplasia of the tongue (HP:0010295)1.51372701
172Supernumerary spleens (HP:0009799)1.48188986
173Absent epiphyses (HP:0010577)1.47929214
174Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.47929214
175True hermaphroditism (HP:0010459)1.45296993
176Gait imbalance (HP:0002141)1.43073380
177Congenital primary aphakia (HP:0007707)1.42889074
178Upper motor neuron abnormality (HP:0002127)1.41081773
179Aplasia/Hypoplasia of the lens (HP:0008063)1.40238408
180Deformed sella turcica (HP:0002681)1.38644679
181Short thorax (HP:0010306)1.36954084
182Abnormal urine output (HP:0012590)1.36644118
183Aplasia/Hypoplasia of the fibula (HP:0006492)1.35698378
184Median cleft lip (HP:0000161)1.34185816
185Broad distal phalanx of finger (HP:0009836)1.31057733
186Nephropathy (HP:0000112)1.28636279
187Hemorrhage of the eye (HP:0011885)1.25322775
188Asymmetric septal hypertrophy (HP:0001670)1.24394434
189Neurofibrillary tangles (HP:0002185)1.23278795
190Bundle branch block (HP:0011710)1.23249572
191Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.21441085
192Polyuria (HP:0000103)1.19186609
193Nephrogenic diabetes insipidus (HP:0009806)1.18908401
194Abnormality of ocular smooth pursuit (HP:0000617)1.18085191
195Breast carcinoma (HP:0003002)1.17199962
196Vascular calcification (HP:0004934)1.16412282
197Constricted visual fields (HP:0001133)1.14003740
19811 pairs of ribs (HP:0000878)1.13113234

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.99973409
2PDK48.99973409
3PDK25.82138040
4TESK14.88437528
5PRKD34.20666884
6ICK3.60580850
7BLK3.21449127
8MAP4K13.19362391
9IRAK43.01192800
10MAP2K33.00522355
11TYK22.58563675
12PNCK2.47318571
13PTK2B2.38209751
14JAK32.36470827
15FES2.29578137
16ZAP702.23794238
17WNK42.22362430
18BTK2.20164227
19TXK2.19172356
20STK392.17089199
21TEC2.06667347
22ACVR1B2.02384886
23SYK2.01971561
24MAP3K142.00955397
25KIT1.99642854
26TAOK31.94804848
27CDK191.93487038
28ERN11.87734811
29TNK21.83638408
30TBK11.79077613
31IKBKE1.77342980
32FGR1.69761180
33GRK61.68373179
34BMPR21.66289499
35MATK1.63082714
36NEK21.62803406
37HCK1.59792192
38MAP3K31.58464648
39ITK1.58352423
40LYN1.55453805
41MAP3K131.53351836
42IKBKB1.43590420
43JAK21.42412530
44STK381.41019709
45JAK11.25717966
46LCK1.22496276
47MAP3K111.20594215
48DYRK1B1.17392444
49EPHB11.13244086
50PIK3CG1.12826676
51TGFBR21.11782430
52MAP3K11.11308998
53GRK71.06029650
54MAP3K61.04313374
55TAOK11.03366276
56PRPF4B1.01622872
57PDK11.01456831
58MAPK150.99559999
59KSR20.99103927
60SIK30.95784108
61WNK10.95379403
62FRK0.94307003
63DYRK30.93712588
64MAP3K20.89665614
65TYRO30.87736365
66HIPK20.76755417
67TAOK20.75773245
68IRAK10.75355394
69TTK0.74771027
70MAP3K50.73278600
71PASK0.73132087
72DAPK20.72075455
73CCNB10.71447849
74STK30.70019605
75CAMK1G0.62678156
76MAP2K20.62119802
77RAF10.62090623
78PINK10.60188811
79YES10.55859163
80MAP2K40.51035249
81CHEK20.50093904
82PIM10.49960902
83FYN0.49804028
84TESK20.49433388
85PDPK10.47883786
86CDC70.46530520
87OXSR10.46523073
88MAP2K60.46365833
89WEE10.45644191
90CHEK10.43529487
91RPS6KC10.43387951
92RPS6KL10.43387951
93MAPK70.42928271
94LMTK20.42715616
95IRAK20.41894938
96ABL10.41857633
97CDK40.41589722
98RPS6KA60.40451540
99MOS0.38637288
100PAK20.35535023
101EPHA30.35508663
102RIPK10.35263247
103NLK0.35260855
104ATR0.34452460
105CAMKK20.34270313
106EEF2K0.33229103
107FGFR30.32326175
108KSR10.32243894
109NTRK20.32166492
110PRKCD0.31937800
111ATM0.31569380
112PAK10.31402954
113MAP3K70.30562916
114RIPK40.30507485
115LRRK20.29907071
116SIK20.27988309
117PRKCG0.27269088
118MUSK0.26781724
119MTOR0.25692347
120CDC42BPA0.24930774
121PTK60.24831383
122MAPKAPK20.24172956
123TLK10.22606134
124CAMKK10.22313927
125CHUK0.22239122
126STK38L0.22032271
127MAPK120.21792060
128MARK20.21782018
129PRKAA10.21263790
130MAPK30.20764279
131PLK10.20371212
132PLK40.20017527
133IGF1R0.19719131
134MAPKAPK50.19703664
135NEK60.16168114
136CDK120.15769979
137BMPR1B0.15350681
138RPS6KB10.15041678
139MAP3K100.14066325
140PAK40.13207684
141BRSK20.13081464
142BRAF0.10936096
143CDK150.10537687
144PRKCQ0.09287268
145CSNK1D0.08805502
146PRKG10.08409283
147CDK180.08052690
148CDK11A0.07607425
149PRKACG0.06762041
150WNK30.06705297
151PRKCZ0.06197199
152PRKG20.06118996
153PKN10.05781416
154CSNK2A10.05774054
155CDK10.05401276
156GSK3B0.05187953
157CDK140.05166084
158STK110.04863917
159MARK30.04841602
160BRSK10.03218013
161PRKDC0.02856010
162MAPK80.02643556
163CDK20.02576170
164CAMK2A0.02488046
165MAP3K40.02245411
166RPS6KA10.02241057
167CLK10.01994036
168CSNK2A20.01461296
169PRKACB0.01004582
170CDK30.00938990
171PRKCB0.00816289
172MAP2K7-0.0343194
173CSNK1E-0.0307833
174PAK6-0.0273004
175CSK-0.0260747
176CSF1R-0.0213883
177AURKA-0.0196354
178CDK6-0.0183676
179EGFR-0.0165394
180STK10-0.0164658
181PRKACA-0.0151898
182PRKCA-0.0055201
183RPS6KA3-0.0011001

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.19154808
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.40068267
3Pyruvate metabolism_Homo sapiens_hsa006204.09069881
4Fatty acid biosynthesis_Homo sapiens_hsa000613.81393447
5Leishmaniasis_Homo sapiens_hsa051403.47882276
6Staphylococcus aureus infection_Homo sapiens_hsa051503.45176328
7Allograft rejection_Homo sapiens_hsa053303.45084815
8Propanoate metabolism_Homo sapiens_hsa006403.36045616
9Graft-versus-host disease_Homo sapiens_hsa053323.33440790
10Asthma_Homo sapiens_hsa053103.16273749
11Autoimmune thyroid disease_Homo sapiens_hsa053203.11768440
12Glucagon signaling pathway_Homo sapiens_hsa049222.84815501
13Osteoclast differentiation_Homo sapiens_hsa043802.71026067
14Type I diabetes mellitus_Homo sapiens_hsa049402.55556749
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.55334189
16Intestinal immune network for IgA production_Homo sapiens_hsa046722.53472547
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.48625719
18Linoleic acid metabolism_Homo sapiens_hsa005912.48021463
19Tuberculosis_Homo sapiens_hsa051522.32348068
20Basal transcription factors_Homo sapiens_hsa030222.32105632
21NOD-like receptor signaling pathway_Homo sapiens_hsa046212.31426332
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.17514708
23Dorso-ventral axis formation_Homo sapiens_hsa043202.11351804
24Selenocompound metabolism_Homo sapiens_hsa004502.08407811
25Carbohydrate digestion and absorption_Homo sapiens_hsa049732.03032243
26Toll-like receptor signaling pathway_Homo sapiens_hsa046202.02429679
27Glycerolipid metabolism_Homo sapiens_hsa005611.94009461
28Pentose phosphate pathway_Homo sapiens_hsa000301.92919853
29Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.89501169
30Oocyte meiosis_Homo sapiens_hsa041141.88208588
31Rheumatoid arthritis_Homo sapiens_hsa053231.88145565
32Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.83155681
33Viral myocarditis_Homo sapiens_hsa054161.81022079
34PPAR signaling pathway_Homo sapiens_hsa033201.79588137
35Hematopoietic cell lineage_Homo sapiens_hsa046401.75350053
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.74259381
37Glycosaminoglycan degradation_Homo sapiens_hsa005311.72560856
38Primary immunodeficiency_Homo sapiens_hsa053401.72224183
39Malaria_Homo sapiens_hsa051441.70150598
40Influenza A_Homo sapiens_hsa051641.68730341
41Amphetamine addiction_Homo sapiens_hsa050311.67652286
42Fanconi anemia pathway_Homo sapiens_hsa034601.67070252
43NF-kappa B signaling pathway_Homo sapiens_hsa040641.63545353
44Toxoplasmosis_Homo sapiens_hsa051451.62790906
45Huntingtons disease_Homo sapiens_hsa050161.58591203
46Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.56066910
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.51590503
48Fructose and mannose metabolism_Homo sapiens_hsa000511.46984644
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.43103103
50RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.42525233
51Phagosome_Homo sapiens_hsa041451.42414549
52Cardiac muscle contraction_Homo sapiens_hsa042601.40506038
53Other glycan degradation_Homo sapiens_hsa005111.40047630
54Herpes simplex infection_Homo sapiens_hsa051681.38387643
55Measles_Homo sapiens_hsa051621.37759598
56Renin secretion_Homo sapiens_hsa049241.37548717
57Carbon metabolism_Homo sapiens_hsa012001.35269289
58Pertussis_Homo sapiens_hsa051331.34580238
59Glycerophospholipid metabolism_Homo sapiens_hsa005641.34446347
60Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.33967406
61Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.32260215
62Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.30896159
63Chemokine signaling pathway_Homo sapiens_hsa040621.28581321
64Jak-STAT signaling pathway_Homo sapiens_hsa046301.27201562
65African trypanosomiasis_Homo sapiens_hsa051431.24277888
66TNF signaling pathway_Homo sapiens_hsa046681.19560222
67Ether lipid metabolism_Homo sapiens_hsa005651.19166307
68Acute myeloid leukemia_Homo sapiens_hsa052211.18773992
69SNARE interactions in vesicular transport_Homo sapiens_hsa041301.16841708
70Mineral absorption_Homo sapiens_hsa049781.15894339
71T cell receptor signaling pathway_Homo sapiens_hsa046601.15685836
72Platelet activation_Homo sapiens_hsa046111.15290304
73Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.14990976
74Salmonella infection_Homo sapiens_hsa051321.12152349
75Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.11662202
76Lysosome_Homo sapiens_hsa041421.11114114
77Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.07712285
78Fatty acid metabolism_Homo sapiens_hsa012121.07151118
79Purine metabolism_Homo sapiens_hsa002301.03749869
80Fat digestion and absorption_Homo sapiens_hsa049751.03351613
81Fatty acid degradation_Homo sapiens_hsa000711.01856747
82mRNA surveillance pathway_Homo sapiens_hsa030151.01471479
83Antigen processing and presentation_Homo sapiens_hsa046120.98104025
84RNA transport_Homo sapiens_hsa030130.95199769
85Long-term potentiation_Homo sapiens_hsa047200.95011501
86Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.94177425
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91547491
88Collecting duct acid secretion_Homo sapiens_hsa049660.89483935
89Biosynthesis of amino acids_Homo sapiens_hsa012300.87194861
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.84768566
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.83468945
92Shigellosis_Homo sapiens_hsa051310.82749451
93Glutathione metabolism_Homo sapiens_hsa004800.81721193
94Hepatitis C_Homo sapiens_hsa051600.79197492
95Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.78595766
96Hepatitis B_Homo sapiens_hsa051610.78105712
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.74928644
98Insulin secretion_Homo sapiens_hsa049110.74148557
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.74100101
100Estrogen signaling pathway_Homo sapiens_hsa049150.73006909
101Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72856827
102Leukocyte transendothelial migration_Homo sapiens_hsa046700.72750762
103Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.68568048
104Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.68211971
105Chemical carcinogenesis_Homo sapiens_hsa052040.68192814
106ABC transporters_Homo sapiens_hsa020100.67318223
107Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67266528
108Calcium signaling pathway_Homo sapiens_hsa040200.67103823
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66303285
110Bile secretion_Homo sapiens_hsa049760.64191387
111Thyroid hormone synthesis_Homo sapiens_hsa049180.63776463
112Arachidonic acid metabolism_Homo sapiens_hsa005900.61230050
113Hedgehog signaling pathway_Homo sapiens_hsa043400.60870097
114Prolactin signaling pathway_Homo sapiens_hsa049170.60768616
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.60635120
116Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59391975
117Apoptosis_Homo sapiens_hsa042100.58696202
118Adipocytokine signaling pathway_Homo sapiens_hsa049200.58501260
119Epstein-Barr virus infection_Homo sapiens_hsa051690.58167444
120Regulation of autophagy_Homo sapiens_hsa041400.56493526
121Non-small cell lung cancer_Homo sapiens_hsa052230.55460327
122Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53473482
123Taste transduction_Homo sapiens_hsa047420.53293651
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.51579583
125Amoebiasis_Homo sapiens_hsa051460.50899857
126VEGF signaling pathway_Homo sapiens_hsa043700.47687612
127Salivary secretion_Homo sapiens_hsa049700.43445688
128Pancreatic cancer_Homo sapiens_hsa052120.42367016
129Circadian entrainment_Homo sapiens_hsa047130.41643296
130AMPK signaling pathway_Homo sapiens_hsa041520.40225315
131Pancreatic secretion_Homo sapiens_hsa049720.39676099
132Synaptic vesicle cycle_Homo sapiens_hsa047210.37950799
133Metabolic pathways_Homo sapiens_hsa011000.37566836
134Vascular smooth muscle contraction_Homo sapiens_hsa042700.37557679
135HTLV-I infection_Homo sapiens_hsa051660.37168766
136Gastric acid secretion_Homo sapiens_hsa049710.36753959
137Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36002178
138FoxO signaling pathway_Homo sapiens_hsa040680.35943000
139cAMP signaling pathway_Homo sapiens_hsa040240.35618781
140AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.34912714
141Legionellosis_Homo sapiens_hsa051340.34438487
142Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.33711746
143Endocytosis_Homo sapiens_hsa041440.33705809
144Neurotrophin signaling pathway_Homo sapiens_hsa047220.32950160
145Inositol phosphate metabolism_Homo sapiens_hsa005620.32780742
146Protein digestion and absorption_Homo sapiens_hsa049740.32353777
147Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31365849
148Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.31051432
149Chronic myeloid leukemia_Homo sapiens_hsa052200.29271304
150Type II diabetes mellitus_Homo sapiens_hsa049300.28810861
151Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26393745
152Glutamatergic synapse_Homo sapiens_hsa047240.26122683
153Renin-angiotensin system_Homo sapiens_hsa046140.25817389
154Pyrimidine metabolism_Homo sapiens_hsa002400.25007554
155Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.23938164
156Thyroid hormone signaling pathway_Homo sapiens_hsa049190.23663711
157Viral carcinogenesis_Homo sapiens_hsa052030.22579838
158GnRH signaling pathway_Homo sapiens_hsa049120.22141185
159Complement and coagulation cascades_Homo sapiens_hsa046100.21874708
160Systemic lupus erythematosus_Homo sapiens_hsa053220.21367068
161Insulin resistance_Homo sapiens_hsa049310.20842585
162Phospholipase D signaling pathway_Homo sapiens_hsa040720.20426280
163HIF-1 signaling pathway_Homo sapiens_hsa040660.20188116
164Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.20079451
165Sulfur metabolism_Homo sapiens_hsa009200.20073044
166Choline metabolism in cancer_Homo sapiens_hsa052310.19941122
167Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.19926031
168MAPK signaling pathway_Homo sapiens_hsa040100.19739598
169B cell receptor signaling pathway_Homo sapiens_hsa046620.19296946
170Cocaine addiction_Homo sapiens_hsa050300.18763862
171Wnt signaling pathway_Homo sapiens_hsa043100.18595496
172Notch signaling pathway_Homo sapiens_hsa043300.17214758
173Olfactory transduction_Homo sapiens_hsa047400.15050070
174Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.14694886
175Alcoholism_Homo sapiens_hsa050340.11815335
176mTOR signaling pathway_Homo sapiens_hsa041500.11386293
177N-Glycan biosynthesis_Homo sapiens_hsa005100.10394905
178Retinol metabolism_Homo sapiens_hsa008300.07920452
179Oxytocin signaling pathway_Homo sapiens_hsa049210.07771088
180Steroid hormone biosynthesis_Homo sapiens_hsa001400.07705397

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