NME7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the non-metastatic expressed family of nucleoside diphosphate kinases. Members of this family are enzymes that catalyzes phosphate transfer from nucleoside triphosphates to nucleoside diphosphates. This protein contains two kinase domains, one of which is involved in autophosphorylation and the other may be inactive. This protein localizes to the centrosome and functions as a component of the gamma-tubulin ring complex which plays a role in microtubule organization. Mutations in this gene may be associated with venous thromboembolism. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.51707407
2mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.02859362
3neuron cell-cell adhesion (GO:0007158)5.00609341
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.98475159
5ATP synthesis coupled proton transport (GO:0015986)4.69928950
6energy coupled proton transport, down electrochemical gradient (GO:0015985)4.69928950
7gamma-aminobutyric acid signaling pathway (GO:0007214)4.35226423
8presynaptic membrane assembly (GO:0097105)4.25708627
9neuronal action potential propagation (GO:0019227)4.24283037
10ionotropic glutamate receptor signaling pathway (GO:0035235)4.20787790
11glutamate receptor signaling pathway (GO:0007215)4.17223866
12respiratory electron transport chain (GO:0022904)4.16840302
13negative regulation of synaptic transmission, GABAergic (GO:0032229)4.14062956
14protein localization to synapse (GO:0035418)4.10701043
15electron transport chain (GO:0022900)4.08519872
16vocalization behavior (GO:0071625)3.96651444
17neuron recognition (GO:0008038)3.89795189
18neurofilament cytoskeleton organization (GO:0060052)3.88189949
19behavioral response to ethanol (GO:0048149)3.87544956
20presynaptic membrane organization (GO:0097090)3.81988466
21establishment of protein localization to mitochondrial membrane (GO:0090151)3.74661770
22substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.73543680
23substrate-independent telencephalic tangential migration (GO:0021826)3.73543680
24negative regulation of cytosolic calcium ion concentration (GO:0051481)3.67814482
25startle response (GO:0001964)3.65992764
26transmission of nerve impulse (GO:0019226)3.63375537
27pyrimidine nucleobase catabolic process (GO:0006208)3.62251553
28protein complex biogenesis (GO:0070271)3.59825527
29neuron-neuron synaptic transmission (GO:0007270)3.58359068
30protein polyglutamylation (GO:0018095)3.53492237
31auditory behavior (GO:0031223)3.48876150
32synaptic transmission, glutamatergic (GO:0035249)3.48515912
33positive regulation of synapse assembly (GO:0051965)3.48053226
34postsynaptic membrane organization (GO:0001941)3.46400670
35mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.43183959
36mitochondrial respiratory chain complex I assembly (GO:0032981)3.43183959
37NADH dehydrogenase complex assembly (GO:0010257)3.43183959
38serotonin receptor signaling pathway (GO:0007210)3.42792432
39regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.39008814
40regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.35377081
41mechanosensory behavior (GO:0007638)3.33292404
42* cilium movement (GO:0003341)3.32225561
43axonal fasciculation (GO:0007413)3.31478817
44cornea development in camera-type eye (GO:0061303)3.26713031
45regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.25925296
46G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.24872636
47* epithelial cilium movement (GO:0003351)3.23323178
48mitochondrial respiratory chain complex assembly (GO:0033108)3.23022268
49chaperone-mediated protein transport (GO:0072321)3.22985471
50serotonin metabolic process (GO:0042428)3.22939748
51response to histamine (GO:0034776)3.20452728
52nonmotile primary cilium assembly (GO:0035058)3.19361018
53detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.18292401
54synaptic vesicle exocytosis (GO:0016079)3.15901148
55negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.12446521
56nucleobase catabolic process (GO:0046113)3.09678635
57protein localization to cilium (GO:0061512)3.09235425
58regulation of short-term neuronal synaptic plasticity (GO:0048172)3.07914014
59dopamine transport (GO:0015872)3.06149557
60axonemal dynein complex assembly (GO:0070286)3.02794842
61epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.01421005
62regulation of vesicle fusion (GO:0031338)3.01381910
63regulation of glutamate receptor signaling pathway (GO:1900449)2.99768817
64gamma-aminobutyric acid transport (GO:0015812)2.98452412
65hydrogen ion transmembrane transport (GO:1902600)2.97775181
66synaptic transmission, cholinergic (GO:0007271)2.97126949
67dendritic spine morphogenesis (GO:0060997)2.96765084
68dopamine biosynthetic process (GO:0042416)2.95992879
69righting reflex (GO:0060013)2.94148212
70female mating behavior (GO:0060180)2.93776652
71response to pheromone (GO:0019236)2.93244427
72positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.92773394
73cilium morphogenesis (GO:0060271)2.92433954
74regulation of protein kinase A signaling (GO:0010738)2.92199375
75positive regulation of cellular response to oxidative stress (GO:1900409)2.92068248
76positive regulation of response to oxidative stress (GO:1902884)2.92068248
77regulation of mitochondrial translation (GO:0070129)2.91476662
78negative regulation of telomere maintenance (GO:0032205)2.91129098
79regulation of glutamate secretion (GO:0014048)2.87410950
80detection of light stimulus involved in sensory perception (GO:0050962)2.85231555
81detection of light stimulus involved in visual perception (GO:0050908)2.85231555
82positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.84363066
83prepulse inhibition (GO:0060134)2.83952247
84axoneme assembly (GO:0035082)2.82603400
85regulation of synapse assembly (GO:0051963)2.82306894
86cilium organization (GO:0044782)2.81325974
87cilium assembly (GO:0042384)2.80115152
88synaptic transmission, dopaminergic (GO:0001963)2.79916469
89ATP hydrolysis coupled proton transport (GO:0015991)2.79143735
90energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.79143735
91respiratory chain complex IV assembly (GO:0008535)2.79043074
92primary amino compound metabolic process (GO:1901160)2.76433414
93long-term memory (GO:0007616)2.75908015
94inner mitochondrial membrane organization (GO:0007007)2.75757277
95protein-cofactor linkage (GO:0018065)2.75564690
96cochlea development (GO:0090102)2.73704937
97membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.73090395
98regulation of catecholamine metabolic process (GO:0042069)2.72657254
99regulation of dopamine metabolic process (GO:0042053)2.72657254
100retinal ganglion cell axon guidance (GO:0031290)2.72224622
101positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.70304572
102* intraciliary transport (GO:0042073)2.69306923
103peristalsis (GO:0030432)2.69206606
104adult walking behavior (GO:0007628)2.68879631
105response to cocaine (GO:0042220)2.68662307
106positive regulation of growth hormone secretion (GO:0060124)2.68135992
107protein neddylation (GO:0045116)2.68128912
108fear response (GO:0042596)2.67805465
109regulation of cilium movement (GO:0003352)2.67542722
110neural tube formation (GO:0001841)2.65605919
111neuron remodeling (GO:0016322)2.65439733
112proton transport (GO:0015992)2.64471503
113DNA double-strand break processing (GO:0000729)2.63868897
114detection of calcium ion (GO:0005513)2.62859363
115regulation of postsynaptic membrane potential (GO:0060078)2.62800174
116synapse assembly (GO:0007416)2.62557762
117response to auditory stimulus (GO:0010996)2.62540786
118regulation of telomere maintenance (GO:0032204)2.61975723
119photoreceptor cell maintenance (GO:0045494)2.61656207
120regulation of neurotransmitter uptake (GO:0051580)2.61540092
121establishment of integrated proviral latency (GO:0075713)2.61439511
122cilium or flagellum-dependent cell motility (GO:0001539)2.61403519
123regulation of long-term neuronal synaptic plasticity (GO:0048169)2.61363014
124positive regulation of action potential (GO:0045760)2.60838497
125regulation of excitatory postsynaptic membrane potential (GO:0060079)2.60597394
126short-term memory (GO:0007614)2.59348080
127hydrogen transport (GO:0006818)2.59220436
128behavioral defense response (GO:0002209)2.59172913
129behavioral fear response (GO:0001662)2.59172913
130regulation of synapse structural plasticity (GO:0051823)2.57784409
131long-term synaptic potentiation (GO:0060291)2.57534591
132regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.57374746
133regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.57374746
134positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.56619681
135glycerophospholipid catabolic process (GO:0046475)2.55658764
136negative regulation of transcription regulatory region DNA binding (GO:2000678)2.55252790
137neurotransmitter transport (GO:0006836)2.53568981
138dendrite development (GO:0016358)2.53219627
139learning (GO:0007612)2.51962783
140neurotransmitter secretion (GO:0007269)2.51902066
141regulation of dopamine secretion (GO:0014059)2.51792464
142behavioral response to cocaine (GO:0048148)2.51544492
143limb bud formation (GO:0060174)2.50488320
144water-soluble vitamin biosynthetic process (GO:0042364)2.50319264
145neuromuscular synaptic transmission (GO:0007274)2.49754101
146regulation of respiratory system process (GO:0044065)2.49638374
147glutamate secretion (GO:0014047)2.49402656
148ganglion development (GO:0061548)2.48328170
149adaptation of signaling pathway (GO:0023058)2.47620279
150motile cilium assembly (GO:0044458)2.46961808
151synaptic vesicle maturation (GO:0016188)2.44401412
152magnesium ion transport (GO:0015693)2.42457817
153regulation of microtubule-based movement (GO:0060632)2.42158088
154cytochrome complex assembly (GO:0017004)2.41807353
155replication fork processing (GO:0031297)2.37199373
156brain morphogenesis (GO:0048854)2.36847507
157striatum development (GO:0021756)2.36559299
158positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.36133064
159olfactory bulb development (GO:0021772)2.34759944
160retina layer formation (GO:0010842)2.34141125
161platelet dense granule organization (GO:0060155)2.31170060
162response to amphetamine (GO:0001975)2.30304103
163regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.29573626
164cell proliferation in forebrain (GO:0021846)2.29376038
165preassembly of GPI anchor in ER membrane (GO:0016254)2.29169869
166indolalkylamine metabolic process (GO:0006586)2.28211444
167hindbrain development (GO:0030902)2.27410772
168photoreceptor cell development (GO:0042461)2.27284935
169retinal cone cell development (GO:0046549)2.26814836

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.33299865
2GBX2_23144817_ChIP-Seq_PC3_Human3.92079892
3TAF15_26573619_Chip-Seq_HEK293_Human3.08052160
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.70716907
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.55418256
6FUS_26573619_Chip-Seq_HEK293_Human2.50781546
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.48502229
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.44593892
9VDR_22108803_ChIP-Seq_LS180_Human2.40001458
10BMI1_23680149_ChIP-Seq_NPCS_Mouse2.39159442
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.39005880
12CTBP1_25329375_ChIP-Seq_LNCAP_Human2.37347848
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.22889658
14CTBP2_25329375_ChIP-Seq_LNCAP_Human2.21429909
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.13263362
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.09423371
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.05137623
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.04629779
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.03023514
20P300_19829295_ChIP-Seq_ESCs_Human2.00262361
21EED_16625203_ChIP-ChIP_MESCs_Mouse1.94611997
22CBX2_27304074_Chip-Seq_ESCs_Mouse1.93234876
23JARID2_20075857_ChIP-Seq_MESCs_Mouse1.87572506
24* REST_21632747_ChIP-Seq_MESCs_Mouse1.87235024
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.86593012
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.81675112
27SALL1_21062744_ChIP-ChIP_HESCs_Human1.77102310
28IGF1R_20145208_ChIP-Seq_DFB_Human1.76574883
29SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.76380276
30CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.75655423
31FLI1_27457419_Chip-Seq_LIVER_Mouse1.72150342
32EZH2_18974828_ChIP-Seq_MESCs_Mouse1.68233337
33RNF2_18974828_ChIP-Seq_MESCs_Mouse1.68233337
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.67174644
35RNF2_27304074_Chip-Seq_NSC_Mouse1.67111114
36SMAD4_21799915_ChIP-Seq_A2780_Human1.63652179
37CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.62386321
38TOP2B_26459242_ChIP-Seq_MCF-7_Human1.60181871
39RBPJ_22232070_ChIP-Seq_NCS_Mouse1.56363696
40MTF2_20144788_ChIP-Seq_MESCs_Mouse1.53534062
41SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.52103849
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50218697
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.49021670
44ER_23166858_ChIP-Seq_MCF-7_Human1.47464590
45KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.47082872
46* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.45973160
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.45493445
48CBP_20019798_ChIP-Seq_JUKART_Human1.44702723
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44702723
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.43724956
51* NANOG_18555785_Chip-Seq_ESCs_Mouse1.42950731
52FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.42843419
53MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40446802
54NR3C1_21868756_ChIP-Seq_MCF10A_Human1.40225743
55EZH2_27294783_Chip-Seq_ESCs_Mouse1.39578465
56EWS_26573619_Chip-Seq_HEK293_Human1.38509081
57SUZ12_27294783_Chip-Seq_ESCs_Mouse1.38197878
58EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.37866835
59ZNF274_21170338_ChIP-Seq_K562_Hela1.37654546
60RNF2_27304074_Chip-Seq_ESCs_Mouse1.37143106
61* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35274935
62* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.34498795
63OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34437735
64NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.32749476
65GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.32577804
66JUN_21703547_ChIP-Seq_K562_Human1.32376443
67KLF5_20875108_ChIP-Seq_MESCs_Mouse1.30298158
68IKZF1_21737484_ChIP-ChIP_HCT116_Human1.28867800
69PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.28684617
70CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26335764
71REST_18959480_ChIP-ChIP_MESCs_Mouse1.25227390
72* P53_22387025_ChIP-Seq_ESCs_Mouse1.25210514
73* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25092705
74* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24880839
75ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.24738777
76AR_25329375_ChIP-Seq_VCAP_Human1.24379605
77KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.22700176
78TCF4_22108803_ChIP-Seq_LS180_Human1.22543274
79* E2F1_18555785_Chip-Seq_ESCs_Mouse1.22542005
80* GABP_17652178_ChIP-ChIP_JURKAT_Human1.21081917
81TP53_22573176_ChIP-Seq_HFKS_Human1.19901962
82RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19480369
83* EZH2_27294783_Chip-Seq_NPCs_Mouse1.18635945
84IRF1_19129219_ChIP-ChIP_H3396_Human1.17881661
85* NFE2_27457419_Chip-Seq_LIVER_Mouse1.16918342
86* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.16792112
87* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.15514147
88SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15133549
89AR_21572438_ChIP-Seq_LNCaP_Human1.14534606
90RUNX2_22187159_ChIP-Seq_PCA_Human1.13914424
91FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.13833872
92CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.12638088
93FLI1_21867929_ChIP-Seq_TH2_Mouse1.12208057
94TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12154466
95CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.12118349
96* P300_18555785_Chip-Seq_ESCs_Mouse1.12081858
97* CMYC_18555785_Chip-Seq_ESCs_Mouse1.11794423
98NANOG_19829295_ChIP-Seq_ESCs_Human1.11259047
99SOX2_19829295_ChIP-Seq_ESCs_Human1.11259047
100BCAT_22108803_ChIP-Seq_LS180_Human1.11133545
101MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10845418
102* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.10055628
103* SOX2_18555785_Chip-Seq_ESCs_Mouse1.09094165
104POU5F1_16153702_ChIP-ChIP_HESCs_Human1.08490916
105STAT3_23295773_ChIP-Seq_U87_Human1.08431482
106MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07921740
107TAL1_26923725_Chip-Seq_HPCs_Mouse1.07333111
108POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06868001
109TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06868001
110* STAT3_18555785_Chip-Seq_ESCs_Mouse1.06337846
111HTT_18923047_ChIP-ChIP_STHdh_Human1.05805293
112HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.05271987
113TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05026327
114PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04844792
115ETV2_25802403_ChIP-Seq_MESCs_Mouse1.04063772
116PRDM14_20953172_ChIP-Seq_ESCs_Human1.03995086
117TCF4_23295773_ChIP-Seq_U87_Human1.03491155
118MYC_18940864_ChIP-ChIP_HL60_Human1.01866010
119KDM2B_26808549_Chip-Seq_REH_Human1.00992958
120* SOX2_21211035_ChIP-Seq_LN229_Gbm1.00864262
121NCOR_22424771_ChIP-Seq_293T_Human1.00844915
122* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.00796145
123* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00355975
124* EST1_17652178_ChIP-ChIP_JURKAT_Human0.97895703
125EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.97674714

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.97815160
2MP0006276_abnormal_autonomic_nervous3.14594999
3MP0009379_abnormal_foot_pigmentation3.01718410
4MP0004859_abnormal_synaptic_plasticity2.99186103
5MP0001188_hyperpigmentation2.96114629
6MP0009745_abnormal_behavioral_response2.89438229
7MP0003635_abnormal_synaptic_transmissio2.86430738
8MP0002736_abnormal_nociception_after2.85781594
9MP0001968_abnormal_touch/_nociception2.84106778
10MP0001529_abnormal_vocalization2.63356272
11MP0009046_muscle_twitch2.50306722
12MP0002064_seizures2.46040559
13MP0002272_abnormal_nervous_system2.44268959
14MP0001501_abnormal_sleep_pattern2.42097057
15MP0002572_abnormal_emotion/affect_behav2.36143512
16MP0002735_abnormal_chemical_nociception2.29751868
17MP0002063_abnormal_learning/memory/cond2.27240920
18MP0004270_analgesia2.26699139
19MP0010386_abnormal_urinary_bladder2.22956321
20MP0001440_abnormal_grooming_behavior2.21758021
21MP0002734_abnormal_mechanical_nocicepti2.15534538
22MP0000569_abnormal_digit_pigmentation2.09752467
23MP0001486_abnormal_startle_reflex2.06191575
24MP0006292_abnormal_olfactory_placode2.01125905
25MP0001905_abnormal_dopamine_level1.97749978
26MP0002067_abnormal_sensory_capabilities1.84221594
27MP0002733_abnormal_thermal_nociception1.81841152
28MP0002638_abnormal_pupillary_reflex1.81591175
29MP0005423_abnormal_somatic_nervous1.79605501
30MP0004142_abnormal_muscle_tone1.76278200
31MP0003787_abnormal_imprinting1.70569629
32MP0001970_abnormal_pain_threshold1.68784630
33MP0001984_abnormal_olfaction1.67439291
34MP0002184_abnormal_innervation1.67320767
35MP0002557_abnormal_social/conspecific_i1.62146375
36MP0000778_abnormal_nervous_system1.61281816
37MP0005409_darkened_coat_color1.60898557
38MP0002876_abnormal_thyroid_physiology1.51617118
39MP0003136_yellow_coat_color1.50857701
40MP0005410_abnormal_fertilization1.47423156
41MP0005084_abnormal_gallbladder_morpholo1.45193015
42MP0004924_abnormal_behavior1.44225187
43MP0005386_behavior/neurological_phenoty1.44225187
44MP0003890_abnormal_embryonic-extraembry1.41360090
45MP0002909_abnormal_adrenal_gland1.40587329
46MP0003122_maternal_imprinting1.38142864
47MP0001485_abnormal_pinna_reflex1.37324365
48MP0002938_white_spotting1.35512248
49MP0004742_abnormal_vestibular_system1.34487982
50MP0003195_calcinosis1.34065896
51MP0002653_abnormal_ependyma_morphology1.33234738
52MP0002822_catalepsy1.32811966
53MP0005645_abnormal_hypothalamus_physiol1.32712611
54MP0002163_abnormal_gland_morphology1.31037686
55MP0005379_endocrine/exocrine_gland_phen1.30512079
56MP0005646_abnormal_pituitary_gland1.29185161
57MP0001986_abnormal_taste_sensitivity1.28243339
58MP0005171_absent_coat_pigmentation1.27869230
59MP0006072_abnormal_retinal_apoptosis1.26491867
60MP0003123_paternal_imprinting1.26228645
61MP0005551_abnormal_eye_electrophysiolog1.25492388
62MP0001963_abnormal_hearing_physiology1.25386469
63MP0008877_abnormal_DNA_methylation1.24346642
64MP0002102_abnormal_ear_morphology1.23954251
65MP0002928_abnormal_bile_duct1.23554792
66MP0002277_abnormal_respiratory_mucosa1.22766704
67MP0000026_abnormal_inner_ear1.21928008
68MP0000566_synostosis1.19539146
69MP0003011_delayed_dark_adaptation1.19186888
70MP0008872_abnormal_physiological_respon1.19178889
71MP0003121_genomic_imprinting1.14753491
72MP0004147_increased_porphyrin_level1.13868495
73MP0002882_abnormal_neuron_morphology1.10971836
74MP0002066_abnormal_motor_capabilities/c1.10244744
75MP0004811_abnormal_neuron_physiology1.06355186
76MP0002837_dystrophic_cardiac_calcinosis1.04368994
77MP0003329_amyloid_beta_deposits1.03609455
78MP0003879_abnormal_hair_cell1.03282437
79MP0002234_abnormal_pharynx_morphology1.02786123
80MP0001664_abnormal_digestion1.02622920
81MP0001502_abnormal_circadian_rhythm1.02009922
82MP0003938_abnormal_ear_development1.01763633
83MP0000631_abnormal_neuroendocrine_gland1.01238879
84MP0002752_abnormal_somatic_nervous1.00092297
85MP0005499_abnormal_olfactory_system0.99985444
86MP0005394_taste/olfaction_phenotype0.99985444
87MP0000427_abnormal_hair_cycle0.99774927
88MP0005195_abnormal_posterior_eye0.99586333
89MP0004145_abnormal_muscle_electrophysio0.99307074
90MP0000955_abnormal_spinal_cord0.94268990
91MP0003315_abnormal_perineum_morphology0.93863796
92MP0003646_muscle_fatigue0.90524829
93MP0005670_abnormal_white_adipose0.88284280
94MP0003698_abnormal_male_reproductive0.86553758
95MP0008569_lethality_at_weaning0.86172944
96MP0009697_abnormal_copulation0.85903658
97MP0008995_early_reproductive_senescence0.85675907
98MP0002751_abnormal_autonomic_nervous0.85657708
99MP0008875_abnormal_xenobiotic_pharmacok0.85086135
100MP0000538_abnormal_urinary_bladder0.84890710
101MP0001177_atelectasis0.83228243
102MP0002152_abnormal_brain_morphology0.82603466
103MP0004133_heterotaxia0.82079642
104MP0002229_neurodegeneration0.81314156
105MP0008789_abnormal_olfactory_epithelium0.80954639
106MP0003941_abnormal_skin_development0.78434372
107MP0002233_abnormal_nose_morphology0.77595627
108MP0000049_abnormal_middle_ear0.77570511
109MP0001324_abnormal_eye_pigmentation0.77345820
110MP0000015_abnormal_ear_pigmentation0.76323390
111MP0003718_maternal_effect0.76034814
112MP0004043_abnormal_pH_regulation0.75816942
113MP0005389_reproductive_system_phenotype0.75612255
114MP0002090_abnormal_vision0.75596407
115MP0004085_abnormal_heartbeat0.75556817
116MP0005253_abnormal_eye_physiology0.74876298
117MP0001293_anophthalmia0.74457309
118MP0004484_altered_response_of0.74335727
119MP0003633_abnormal_nervous_system0.73028498
120MP0002160_abnormal_reproductive_system0.71029635
121MP0006035_abnormal_mitochondrial_morpho0.70968540
122MP0000462_abnormal_digestive_system0.67491255
123MP0000678_abnormal_parathyroid_gland0.63982381
124MP0004885_abnormal_endolymph0.63973791
125MP0000372_irregular_coat_pigmentation0.60665802

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.48407361
2Dynein arm defect of respiratory motile cilia (HP:0012255)4.21464594
3Absent/shortened dynein arms (HP:0200106)4.21464594
4Acute necrotizing encephalopathy (HP:0006965)4.11631012
5Abnormal ciliary motility (HP:0012262)4.01076876
6Mitochondrial inheritance (HP:0001427)3.87463011
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.78561689
8Atonic seizures (HP:0010819)3.76765124
9Abnormal respiratory motile cilium physiology (HP:0012261)3.68219647
10Abnormal respiratory epithelium morphology (HP:0012253)3.66312000
11Abnormal respiratory motile cilium morphology (HP:0005938)3.66312000
12Increased hepatocellular lipid droplets (HP:0006565)3.59464207
13Progressive macrocephaly (HP:0004481)3.58119654
14Abnormal mitochondria in muscle tissue (HP:0008316)3.56707738
15Epileptic encephalopathy (HP:0200134)3.46886055
16Febrile seizures (HP:0002373)3.35170216
17Hyperventilation (HP:0002883)3.33358732
18Increased CSF lactate (HP:0002490)3.19961646
19Renal Fanconi syndrome (HP:0001994)3.15923504
20Acute encephalopathy (HP:0006846)3.15339657
21Medial flaring of the eyebrow (HP:0010747)3.07228165
22Focal seizures (HP:0007359)3.01819686
23Hepatocellular necrosis (HP:0001404)2.91854752
24Hypothermia (HP:0002045)2.90806344
25Lipid accumulation in hepatocytes (HP:0006561)2.88184676
26Absence seizures (HP:0002121)2.83659400
27Congenital stationary night blindness (HP:0007642)2.83403166
28Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.80323526
29Chronic hepatic failure (HP:0100626)2.74996560
30Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.72369924
31Gait imbalance (HP:0002141)2.68478890
32Dialeptic seizures (HP:0011146)2.62116511
33Nephrogenic diabetes insipidus (HP:0009806)2.60667034
34Congenital primary aphakia (HP:0007707)2.58680858
35Rhinitis (HP:0012384)2.58385137
36Optic disc pallor (HP:0000543)2.49691812
37Abnormality of renal resorption (HP:0011038)2.48086146
38Genital tract atresia (HP:0001827)2.45611090
39Cystic liver disease (HP:0006706)2.45523387
40Agitation (HP:0000713)2.43801000
41Tubulointerstitial nephritis (HP:0001970)2.43597832
42Intestinal atresia (HP:0011100)2.42947399
43Vaginal atresia (HP:0000148)2.41461177
44Aplasia/Hypoplasia of the tongue (HP:0010295)2.39503564
45Nephronophthisis (HP:0000090)2.37301244
46Sclerocornea (HP:0000647)2.35837363
47Tubular atrophy (HP:0000092)2.34974555
48Abnormality of the renal cortex (HP:0011035)2.34827317
49Abolished electroretinogram (ERG) (HP:0000550)2.34758976
50Abnormal rod and cone electroretinograms (HP:0008323)2.34076942
51Abnormal hair whorl (HP:0010721)2.31458175
52Limb dystonia (HP:0002451)2.31221674
53Broad-based gait (HP:0002136)2.28426330
54Progressive cerebellar ataxia (HP:0002073)2.25875787
55Gaze-evoked nystagmus (HP:0000640)2.23809152
56Retinal dysplasia (HP:0007973)2.23542671
57Polyphagia (HP:0002591)2.23328215
58Postaxial hand polydactyly (HP:0001162)2.23229058
59Molar tooth sign on MRI (HP:0002419)2.22370984
60Abnormality of midbrain morphology (HP:0002418)2.22370984
61Generalized tonic-clonic seizures (HP:0002069)2.21477571
62Absent speech (HP:0001344)2.15401184
63Exercise intolerance (HP:0003546)2.15258387
64Postaxial foot polydactyly (HP:0001830)2.12241459
65Pancreatic fibrosis (HP:0100732)2.12041130
66Hyperglycinemia (HP:0002154)2.10678129
67Anencephaly (HP:0002323)2.10653601
68Neoplasm of the adrenal cortex (HP:0100641)2.10438964
69Abnormality of the renal medulla (HP:0100957)2.09557094
70Aplasia/Hypoplasia of the tibia (HP:0005772)2.09073809
71Increased intramyocellular lipid droplets (HP:0012240)2.07736019
72Fair hair (HP:0002286)2.07300401
73Protruding tongue (HP:0010808)2.07028311
74Visual hallucinations (HP:0002367)2.06926178
75Specific learning disability (HP:0001328)2.06665571
76Methylmalonic acidemia (HP:0002912)2.06003319
77Lissencephaly (HP:0001339)2.04801468
78Narrow forehead (HP:0000341)2.04438603
79Chronic bronchitis (HP:0004469)2.03900898
80Exertional dyspnea (HP:0002875)2.02766190
81Abnormality of the labia minora (HP:0012880)2.02508647
82Myokymia (HP:0002411)2.01676060
83Hepatoblastoma (HP:0002884)2.01528746
84Adrenal hypoplasia (HP:0000835)2.01470621
85Hepatic necrosis (HP:0002605)2.01115829
86Congenital hepatic fibrosis (HP:0002612)2.00585098
87Bony spicule pigmentary retinopathy (HP:0007737)1.97345808
88Absent rod-and cone-mediated responses on ERG (HP:0007688)1.96311144
89Pachygyria (HP:0001302)1.96133312
90Amblyopia (HP:0000646)1.93664041
91Increased serum lactate (HP:0002151)1.93145615
92Type II lissencephaly (HP:0007260)1.92604730
93Inability to walk (HP:0002540)1.91464200
94Abnormality of the lacrimal duct (HP:0011481)1.91060095
95Respiratory failure (HP:0002878)1.90830506
96Retinitis pigmentosa (HP:0000510)1.90807223
97Male pseudohermaphroditism (HP:0000037)1.90015476
98Broad foot (HP:0001769)1.88498351
99Metaphyseal dysplasia (HP:0100255)1.88170467
100Preaxial hand polydactyly (HP:0001177)1.87607645
101Microvesicular hepatic steatosis (HP:0001414)1.86902497
102Poor coordination (HP:0002370)1.86523195
103Furrowed tongue (HP:0000221)1.84866195
104Hyperthyroidism (HP:0000836)1.84473085
105Renal cortical cysts (HP:0000803)1.84239253
106Respiratory difficulties (HP:0002880)1.84015940
107Abnormal drinking behavior (HP:0030082)1.83383394
108Polydipsia (HP:0001959)1.83383394
109Volvulus (HP:0002580)1.82225494
110Lactic acidosis (HP:0003128)1.81186420
111Prominent nasal bridge (HP:0000426)1.80893292
112Congenital sensorineural hearing impairment (HP:0008527)1.80149782
113Oligodactyly (hands) (HP:0001180)1.79553617
114Optic nerve hypoplasia (HP:0000609)1.79451350
115Cupped ear (HP:0000378)1.79070614
116Gastrointestinal atresia (HP:0002589)1.79029919
117Pancreatic cysts (HP:0001737)1.78880488
118Dandy-Walker malformation (HP:0001305)1.78357256
119Occipital encephalocele (HP:0002085)1.78352085
120Genetic anticipation (HP:0003743)1.78244914
121Thyroid-stimulating hormone excess (HP:0002925)1.77609032
122True hermaphroditism (HP:0010459)1.77171879
123Excessive salivation (HP:0003781)1.77169574
124Drooling (HP:0002307)1.77169574
125Aplasia/Hypoplasia of the lens (HP:0008063)1.77118010
126Decreased circulating renin level (HP:0003351)1.76047496
127Hemiparesis (HP:0001269)1.75620111
128Progressive external ophthalmoplegia (HP:0000590)1.75454490
1293-Methylglutaconic aciduria (HP:0003535)1.74942031
130Abnormality of the nasolacrimal system (HP:0000614)1.74122456
131Cerebral edema (HP:0002181)1.73837203
132Hyperphosphaturia (HP:0003109)1.73698879
133Poor suck (HP:0002033)1.72877485
134Nasolacrimal duct obstruction (HP:0000579)1.71956588
135Median cleft lip (HP:0000161)1.71598521
136Leukodystrophy (HP:0002415)1.70657772
137Atelectasis (HP:0100750)1.70521582
138Abnormality of the axillary hair (HP:0100134)1.68597430
139Abnormality of secondary sexual hair (HP:0009888)1.68597430
140Congenital malformation of the right heart (HP:0011723)1.67051158
141Double outlet right ventricle (HP:0001719)1.67051158
142Progressive inability to walk (HP:0002505)1.64988500
143X-linked dominant inheritance (HP:0001423)1.64355350
144Absent eyebrow (HP:0002223)1.64028905
145Delusions (HP:0000746)1.63160614
146Esotropia (HP:0000565)1.62428612
147Aganglionic megacolon (HP:0002251)1.62325673
148Metabolic alkalosis (HP:0200114)1.62096700
149Supernumerary spleens (HP:0009799)1.59432039

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.78753075
2CASK4.36462779
3PNCK3.55103655
4NTRK33.41103813
5EPHA43.24236483
6MAP3K122.59346968
7STK162.51947569
8MAP2K72.47633144
9MAP4K22.39515983
10PINK12.22864626
11NME12.18763696
12TNIK2.00545732
13MAP3K41.99004240
14TLK11.96467441
15RIPK41.96267683
16BMPR21.91104852
17STK391.88388685
18PLK21.69776420
19ACVR1B1.62238353
20AKT31.55882501
21MINK11.53462251
22MKNK21.52216230
23OXSR11.51109905
24LMTK21.46875169
25BRAF1.43318207
26GRK71.40729599
27DYRK21.38082934
28CAMK2A1.32765784
29ARAF1.28467134
30VRK11.25978877
31BMPR1B1.25923207
32CAMK2B1.25914804
33TRIM281.25723781
34WNK41.24863412
35BCR1.21209457
36MAP2K41.19093858
37MAPK131.19032580
38MARK11.17583976
39TAOK31.16491279
40MST41.16294714
41GRK51.13968831
42INSRR1.12600020
43MUSK1.12042014
44ADRBK21.08134066
45BUB11.06725993
46SRPK11.06145240
47FGR1.02488348
48PRKCG0.99746780
49NTRK10.96711929
50WNK30.96168218
51ERBB30.94882594
52PRPF4B0.94086029
53PBK0.92128136
54PHKG20.91503327
55PHKG10.91503327
56NTRK20.88249566
57PRKCE0.88022975
58SIK20.86701816
59FES0.86580941
60YES10.84713023
61CAMK2D0.84262811
62MAP3K90.83661945
63PTK2B0.82130416
64NEK60.82025292
65CDK190.81840512
66CSNK1A1L0.80633629
67MKNK10.76787354
68CDK50.76282149
69CDK80.74094560
70CAMK1G0.72497805
71PLK30.72224909
72PIK3CA0.70892420
73MAPKAPK50.70857754
74CSNK1G20.69190198
75DYRK1A0.69012508
76CAMKK20.68619011
77STK30.67946774
78CSNK1G30.67752727
79CAMK2G0.67143953
80IRAK10.66599272
81FER0.66593551
82CCNB10.65514503
83CDK30.63291867
84WEE10.63193467
85SGK20.61370034
86PLK40.60846119
87MAP2K60.60656963
88FGFR20.58890796
89DAPK10.58403822
90STK38L0.58346096
91TSSK60.56672602
92ADRBK10.56449305
93UHMK10.55736116
94AURKA0.54133963
95CDC70.53479345
96SGK4940.53062812
97SGK2230.53062812
98PRKCI0.52552902
99PRKACA0.52377211
100PDK40.51627322
101PDK30.51627322
102ROCK20.51112109
103STK380.50668894
104KSR10.50190636
105TNK20.50170121
106NUAK10.48761203
107MAPK150.48411438
108BCKDK0.48259981
109IRAK20.48207862
110CDK140.47874170
111MAP3K130.47138516
112CSNK1E0.45809008
113CAMK10.45275220
114CSNK1A10.44948470
115TTK0.43682109
116DAPK20.43008935
117DYRK30.41648656
118CDK180.41557061
119PLK10.40998070
120EIF2AK30.40694412
121CSNK1G10.40025918
122PAK30.39577408
123PRKCZ0.39233334
124EPHB20.38463243
125WNK10.38143709
126CDK150.37427609
127SGK10.37096777
128PRKG10.36517348
129ZAK0.36407467
130PKN10.35812144
131GRK10.35808420
132TIE10.35090150
133BRSK20.34878378
134STK110.33228263
135LIMK10.32230263
136CAMK1D0.31758724
137PRKD30.30145890
138RPS6KA50.28331245
139CSNK1D0.28323149
140PRKAA10.27958375
141TXK0.27255373
142PRKCQ0.27082853
143TGFBR10.26660365

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.65083773
2Oxidative phosphorylation_Homo sapiens_hsa001904.45508772
3Parkinsons disease_Homo sapiens_hsa050123.46729632
4Alzheimers disease_Homo sapiens_hsa050103.02693816
5Huntingtons disease_Homo sapiens_hsa050162.86317038
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.62430394
7Taste transduction_Homo sapiens_hsa047422.57504884
8Collecting duct acid secretion_Homo sapiens_hsa049662.39856248
9Amphetamine addiction_Homo sapiens_hsa050312.25176209
10Synaptic vesicle cycle_Homo sapiens_hsa047212.18749371
11Serotonergic synapse_Homo sapiens_hsa047262.18556654
12Butanoate metabolism_Homo sapiens_hsa006502.11523957
13GABAergic synapse_Homo sapiens_hsa047272.09610766
14Cardiac muscle contraction_Homo sapiens_hsa042602.08619831
15Morphine addiction_Homo sapiens_hsa050322.04522416
16Glutamatergic synapse_Homo sapiens_hsa047241.99542769
17Long-term potentiation_Homo sapiens_hsa047201.98718296
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.95657149
19Propanoate metabolism_Homo sapiens_hsa006401.84173293
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.78353173
21Protein export_Homo sapiens_hsa030601.75144349
22Circadian entrainment_Homo sapiens_hsa047131.73595245
23Ribosome_Homo sapiens_hsa030101.70914863
24Primary bile acid biosynthesis_Homo sapiens_hsa001201.68920950
25Dopaminergic synapse_Homo sapiens_hsa047281.66667988
26Long-term depression_Homo sapiens_hsa047301.61132228
27RNA polymerase_Homo sapiens_hsa030201.61107671
28Vibrio cholerae infection_Homo sapiens_hsa051101.59383063
29Salivary secretion_Homo sapiens_hsa049701.57286097
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.53999072
31Cocaine addiction_Homo sapiens_hsa050301.47981288
32Calcium signaling pathway_Homo sapiens_hsa040201.44771883
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.43380719
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.39806792
35Steroid biosynthesis_Homo sapiens_hsa001001.37872272
36Renin secretion_Homo sapiens_hsa049241.27236891
37Phototransduction_Homo sapiens_hsa047441.26923533
38Nitrogen metabolism_Homo sapiens_hsa009101.25947687
39Insulin secretion_Homo sapiens_hsa049111.25590654
40Olfactory transduction_Homo sapiens_hsa047401.25060794
41Selenocompound metabolism_Homo sapiens_hsa004501.20658847
42Tryptophan metabolism_Homo sapiens_hsa003801.17753328
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.16542792
44Regulation of autophagy_Homo sapiens_hsa041401.16046429
45Proteasome_Homo sapiens_hsa030501.15657093
46Gastric acid secretion_Homo sapiens_hsa049711.10260602
47Cholinergic synapse_Homo sapiens_hsa047251.09995574
48Steroid hormone biosynthesis_Homo sapiens_hsa001401.03173225
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.97301382
50Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.97115529
51Peroxisome_Homo sapiens_hsa041460.96540325
52Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.95342085
53beta-Alanine metabolism_Homo sapiens_hsa004100.95319083
54Fanconi anemia pathway_Homo sapiens_hsa034600.93461586
55Caffeine metabolism_Homo sapiens_hsa002320.91456984
56Homologous recombination_Homo sapiens_hsa034400.90849920
57Retinol metabolism_Homo sapiens_hsa008300.90816129
58Chemical carcinogenesis_Homo sapiens_hsa052040.86939245
59Oxytocin signaling pathway_Homo sapiens_hsa049210.82677947
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82641259
61Oocyte meiosis_Homo sapiens_hsa041140.82289121
62Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.82262958
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.81219931
64Axon guidance_Homo sapiens_hsa043600.79904992
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.78665643
66Basal transcription factors_Homo sapiens_hsa030220.78561060
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77914618
68cAMP signaling pathway_Homo sapiens_hsa040240.76178035
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.76099932
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.73209664
71Gap junction_Homo sapiens_hsa045400.73143672
72Fatty acid elongation_Homo sapiens_hsa000620.72445928
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.72151984
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69054812
75Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.68851555
76GnRH signaling pathway_Homo sapiens_hsa049120.67594218
77Glycerolipid metabolism_Homo sapiens_hsa005610.67241380
78* Purine metabolism_Homo sapiens_hsa002300.67152921
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.66920595
80Aldosterone synthesis and secretion_Homo sapiens_hsa049250.66916855
81Pancreatic secretion_Homo sapiens_hsa049720.66632241
82Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.66370271
83Melanogenesis_Homo sapiens_hsa049160.66143509
84Dorso-ventral axis formation_Homo sapiens_hsa043200.65132346
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.64226365
86Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.64130758
87Hedgehog signaling pathway_Homo sapiens_hsa043400.62837274
88Alcoholism_Homo sapiens_hsa050340.62059048
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61635779
90Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.61336354
91Non-homologous end-joining_Homo sapiens_hsa034500.61007409
92Rheumatoid arthritis_Homo sapiens_hsa053230.60610493
93Nucleotide excision repair_Homo sapiens_hsa034200.59996229
94Sphingolipid metabolism_Homo sapiens_hsa006000.58109211
95* Pyrimidine metabolism_Homo sapiens_hsa002400.56569319
96Ether lipid metabolism_Homo sapiens_hsa005650.55628857
97Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.55610906
98Cysteine and methionine metabolism_Homo sapiens_hsa002700.54559978
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54343631
100Mineral absorption_Homo sapiens_hsa049780.53964442
101Vascular smooth muscle contraction_Homo sapiens_hsa042700.51658608
102Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51348400
103RNA degradation_Homo sapiens_hsa030180.49652302
104Pyruvate metabolism_Homo sapiens_hsa006200.49121097
105cGMP-PKG signaling pathway_Homo sapiens_hsa040220.48543198
106Ovarian steroidogenesis_Homo sapiens_hsa049130.47875411
107Fatty acid metabolism_Homo sapiens_hsa012120.46828489
108African trypanosomiasis_Homo sapiens_hsa051430.46826205
109ABC transporters_Homo sapiens_hsa020100.44542646
110Fatty acid degradation_Homo sapiens_hsa000710.44465902
111Estrogen signaling pathway_Homo sapiens_hsa049150.44282945
112Wnt signaling pathway_Homo sapiens_hsa043100.44270907
113Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42863818
114Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41496050
115Spliceosome_Homo sapiens_hsa030400.41406329
116Mismatch repair_Homo sapiens_hsa034300.41115173
117* Metabolic pathways_Homo sapiens_hsa011000.41002181
118Thyroid hormone synthesis_Homo sapiens_hsa049180.40627233
119Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40347450
120Folate biosynthesis_Homo sapiens_hsa007900.38889225
121Hippo signaling pathway_Homo sapiens_hsa043900.37486406
122Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.37360148
123Arachidonic acid metabolism_Homo sapiens_hsa005900.37029906
124Histidine metabolism_Homo sapiens_hsa003400.36973262
125Type I diabetes mellitus_Homo sapiens_hsa049400.35601857
126Sulfur metabolism_Homo sapiens_hsa009200.34873484
127Phosphatidylinositol signaling system_Homo sapiens_hsa040700.34426413
128Choline metabolism in cancer_Homo sapiens_hsa052310.32458522
129Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.31449804
130Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.27255683
131Ras signaling pathway_Homo sapiens_hsa040140.24434903
132Tyrosine metabolism_Homo sapiens_hsa003500.20655140
133Melanoma_Homo sapiens_hsa052180.19107746
134MAPK signaling pathway_Homo sapiens_hsa040100.19072104
135Linoleic acid metabolism_Homo sapiens_hsa005910.18195075
136ErbB signaling pathway_Homo sapiens_hsa040120.17909541
137Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.16558966
138Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.15749914
139Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.15139964
140mRNA surveillance pathway_Homo sapiens_hsa030150.14838779
141RNA transport_Homo sapiens_hsa030130.14285039

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