NME6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Nucleoside diphosphate (NDP) kinases (EC 2.7.4.6), such as NME6, are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates (Mehus et al., 1999 [PubMed 10453732]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.81204891
2DNA deamination (GO:0045006)5.24226453
3maturation of SSU-rRNA (GO:0030490)5.10300324
4mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.09639688
5mitochondrial respiratory chain complex I assembly (GO:0032981)5.09639688
6NADH dehydrogenase complex assembly (GO:0010257)5.09639688
7protein complex biogenesis (GO:0070271)5.02650075
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.96527010
9ATP synthesis coupled proton transport (GO:0015986)4.75370068
10energy coupled proton transport, down electrochemical gradient (GO:0015985)4.75370068
11mitochondrial respiratory chain complex assembly (GO:0033108)4.72928246
12proteasome assembly (GO:0043248)4.70153314
13ribosomal large subunit biogenesis (GO:0042273)4.61448996
14viral transcription (GO:0019083)4.57121368
15translational termination (GO:0006415)4.48737027
16telomere maintenance via semi-conservative replication (GO:0032201)4.44452187
17DNA strand elongation involved in DNA replication (GO:0006271)4.43647488
18ribosomal small subunit biogenesis (GO:0042274)4.40291652
19behavioral response to nicotine (GO:0035095)4.35422755
20mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.31863297
21DNA strand elongation (GO:0022616)4.25072902
22formation of translation preinitiation complex (GO:0001731)4.24564764
23translational elongation (GO:0006414)4.10126434
24establishment of protein localization to mitochondrial membrane (GO:0090151)4.07718145
25DNA replication initiation (GO:0006270)4.02566050
26ribonucleoprotein complex biogenesis (GO:0022613)3.97458489
27DNA replication checkpoint (GO:0000076)3.97292957
28negative regulation of telomere maintenance (GO:0032205)3.97122817
29SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.96943670
30telomere maintenance via recombination (GO:0000722)3.93677287
31platelet dense granule organization (GO:0060155)3.93310058
32translational initiation (GO:0006413)3.88722368
33respiratory chain complex IV assembly (GO:0008535)3.88236074
34cotranslational protein targeting to membrane (GO:0006613)3.87785870
35nucleobase biosynthetic process (GO:0046112)3.85198550
36protein targeting to ER (GO:0045047)3.84502416
37negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.82320028
38CENP-A containing nucleosome assembly (GO:0034080)3.81373644
39chaperone-mediated protein transport (GO:0072321)3.80555167
40electron transport chain (GO:0022900)3.79703913
41purine nucleobase biosynthetic process (GO:0009113)3.79452023
42respiratory electron transport chain (GO:0022904)3.78154057
43deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.77762146
44protein-cofactor linkage (GO:0018065)3.70224349
45chromatin remodeling at centromere (GO:0031055)3.70123957
46protein localization to endoplasmic reticulum (GO:0070972)3.69578809
47spliceosomal snRNP assembly (GO:0000387)3.68835935
48regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.66944712
49viral mRNA export from host cell nucleus (GO:0046784)3.65626369
50rRNA processing (GO:0006364)3.65609486
51positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.65392791
52rRNA modification (GO:0000154)3.64530585
53mitotic recombination (GO:0006312)3.64378387
54ribosome biogenesis (GO:0042254)3.63546340
55establishment of protein localization to endoplasmic reticulum (GO:0072599)3.62333178
56water-soluble vitamin biosynthetic process (GO:0042364)3.61927012
57cytochrome complex assembly (GO:0017004)3.60546498
58anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.60217758
59nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.60086792
60translation (GO:0006412)3.57521935
61telomere maintenance via telomere lengthening (GO:0010833)3.55828394
62rRNA metabolic process (GO:0016072)3.54584616
63mitotic metaphase plate congression (GO:0007080)3.54552440
64preassembly of GPI anchor in ER membrane (GO:0016254)3.53369438
65cellular protein complex disassembly (GO:0043624)3.52623166
66pseudouridine synthesis (GO:0001522)3.47427603
67viral life cycle (GO:0019058)3.46933381
68negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.46752902
69negative regulation of ligase activity (GO:0051352)3.46752902
70mannosylation (GO:0097502)3.45781911
71sequestering of actin monomers (GO:0042989)3.43431657
72exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.42805019
73transcription elongation from RNA polymerase III promoter (GO:0006385)3.41898203
74termination of RNA polymerase III transcription (GO:0006386)3.41898203
75ubiquinone biosynthetic process (GO:0006744)3.35609012
76tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.35352002
77RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.35352002
78transcription-coupled nucleotide-excision repair (GO:0006283)3.34359048
79DNA replication-independent nucleosome organization (GO:0034724)3.32285609
80DNA replication-independent nucleosome assembly (GO:0006336)3.32285609
81regulation of cellular amino acid metabolic process (GO:0006521)3.31490901
82ribosome assembly (GO:0042255)3.31152451
83cellular component biogenesis (GO:0044085)3.31097643
84nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.28974422
85kinetochore organization (GO:0051383)3.28736457
86nucleotide-excision repair, DNA gap filling (GO:0006297)3.27459434
87protein neddylation (GO:0045116)3.26834656
88DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.26357096
89DNA unwinding involved in DNA replication (GO:0006268)3.25647677
90IMP biosynthetic process (GO:0006188)3.22778282
91kinetochore assembly (GO:0051382)3.22590851
927-methylguanosine mRNA capping (GO:0006370)3.21908185
93intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.21314979
94signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.21314979
95positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.20722566
96signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.20623305
97signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.20623305
98signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.20623305
99epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.19077064
100protein K6-linked ubiquitination (GO:0085020)3.19042614
101DNA damage response, detection of DNA damage (GO:0042769)3.18815739
102L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.18057572
103regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.17249659
104RNA capping (GO:0036260)3.15648298
1057-methylguanosine RNA capping (GO:0009452)3.15648298
106fucose catabolic process (GO:0019317)3.15409184
107L-fucose metabolic process (GO:0042354)3.15409184
108L-fucose catabolic process (GO:0042355)3.15409184
109signal transduction involved in DNA damage checkpoint (GO:0072422)3.15126005
110signal transduction involved in DNA integrity checkpoint (GO:0072401)3.15126005
111protein complex disassembly (GO:0043241)3.14961034
112cullin deneddylation (GO:0010388)3.14004825
113spliceosomal complex assembly (GO:0000245)3.13957599
114folic acid-containing compound biosynthetic process (GO:0009396)3.13695924
115epithelial cilium movement (GO:0003351)3.13254931
116ubiquinone metabolic process (GO:0006743)3.12697204
117protein localization to kinetochore (GO:0034501)3.11366287
118signal transduction involved in cell cycle checkpoint (GO:0072395)3.10863309
119attachment of spindle microtubules to kinetochore (GO:0008608)3.10035671
120positive regulation of ligase activity (GO:0051351)3.09595179
121metaphase plate congression (GO:0051310)3.09045543
122protein deneddylation (GO:0000338)3.08951376
123deoxyribonucleotide biosynthetic process (GO:0009263)3.08429891
124regulation of double-strand break repair via homologous recombination (GO:0010569)3.07759912
125antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.07314034
126histone exchange (GO:0043486)3.07295833
127G1/S transition of mitotic cell cycle (GO:0000082)3.05317413
128cell cycle G1/S phase transition (GO:0044843)3.05317413
129GPI anchor metabolic process (GO:0006505)3.04735848
130nuclear-transcribed mRNA catabolic process (GO:0000956)3.03820436
131macromolecular complex disassembly (GO:0032984)3.03617575
132protein localization to chromosome, centromeric region (GO:0071459)3.01199947
133intracellular protein transmembrane import (GO:0044743)3.00413280
134detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.98084095
135maturation of 5.8S rRNA (GO:0000460)2.94888700
136establishment of integrated proviral latency (GO:0075713)2.93437708
137replication fork processing (GO:0031297)2.91385146
138cellular ketone body metabolic process (GO:0046950)2.90203190
139mRNA catabolic process (GO:0006402)2.88394780
140hydrogen ion transmembrane transport (GO:1902600)2.82961715
141proton transport (GO:0015992)2.81503529
142nucleotide transmembrane transport (GO:1901679)2.78749873
143nonmotile primary cilium assembly (GO:0035058)2.78521790
144peptidyl-histidine modification (GO:0018202)2.78248414
145GPI anchor biosynthetic process (GO:0006506)2.78117346
146regulation of cilium movement (GO:0003352)2.75576061
147indolalkylamine metabolic process (GO:0006586)2.75321481
148hydrogen transport (GO:0006818)2.74001807
149ATP biosynthetic process (GO:0006754)2.73856288
150tRNA processing (GO:0008033)2.73818706
151kynurenine metabolic process (GO:0070189)2.66918146
152C-terminal protein lipidation (GO:0006501)2.65871316
153* purine nucleoside triphosphate biosynthetic process (GO:0009145)2.65820596
154ketone body metabolic process (GO:1902224)2.65475046
155intraciliary transport (GO:0042073)2.63653233
156inner mitochondrial membrane organization (GO:0007007)2.62414051
157response to pheromone (GO:0019236)2.61394268
158* purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.61110219
159regulation of mitochondrial translation (GO:0070129)2.60769568
160protein polyglutamylation (GO:0018095)2.59712139
161recombinational repair (GO:0000725)2.59283143
162base-excision repair, AP site formation (GO:0006285)2.57610324
163reciprocal meiotic recombination (GO:0007131)2.57581975
164reciprocal DNA recombination (GO:0035825)2.57581975
165quinone biosynthetic process (GO:1901663)2.57227561
166indole-containing compound catabolic process (GO:0042436)2.56744685
167indolalkylamine catabolic process (GO:0046218)2.56744685
168tryptophan catabolic process (GO:0006569)2.56744685
169double-strand break repair via homologous recombination (GO:0000724)2.55696786
170negative regulation of transcription regulatory region DNA binding (GO:2000678)2.54962681
171regulation of glucokinase activity (GO:0033131)2.53692196
172regulation of hexokinase activity (GO:1903299)2.53692196
173C-terminal protein amino acid modification (GO:0018410)2.53157277
174centriole replication (GO:0007099)2.52995767
175negative regulation of DNA-dependent DNA replication (GO:2000104)2.48812921
176metallo-sulfur cluster assembly (GO:0031163)2.47125632
177iron-sulfur cluster assembly (GO:0016226)2.47125632
178RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.46793524
179L-methionine salvage (GO:0071267)2.45961603
180L-methionine biosynthetic process (GO:0071265)2.45961603
181amino acid salvage (GO:0043102)2.45961603

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.72627399
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.39420043
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.90006976
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.79638961
5ZNF274_21170338_ChIP-Seq_K562_Hela3.67804547
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.51346275
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.47519184
8* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.47038520
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.23939494
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.10556204
11E2F4_17652178_ChIP-ChIP_JURKAT_Human3.04389420
12CREB1_15753290_ChIP-ChIP_HEK293T_Human3.00761415
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.89124254
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.88903761
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.85019131
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.82477657
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.76070356
18VDR_22108803_ChIP-Seq_LS180_Human2.72697770
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.61237395
20FOXM1_23109430_ChIP-Seq_U2OS_Human2.57271423
21VDR_23849224_ChIP-Seq_CD4+_Human2.46525421
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.45423760
23XRN2_22483619_ChIP-Seq_HELA_Human2.45180282
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.43820389
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.41468126
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.39425756
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.33557383
28* DCP1A_22483619_ChIP-Seq_HELA_Human2.27190426
29* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.22336878
30FOXP3_21729870_ChIP-Seq_TREG_Human2.19938219
31E2F1_18555785_ChIP-Seq_MESCs_Mouse2.18113639
32EWS_26573619_Chip-Seq_HEK293_Human2.10449827
33THAP11_20581084_ChIP-Seq_MESCs_Mouse2.04720116
34SRF_21415370_ChIP-Seq_HL-1_Mouse2.04547294
35GABP_19822575_ChIP-Seq_HepG2_Human2.01792561
36HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.95407942
37TTF2_22483619_ChIP-Seq_HELA_Human1.94823883
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.92174274
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.91999813
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.90379743
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88746479
42FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.88703423
43IRF1_19129219_ChIP-ChIP_H3396_Human1.82763343
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.82139762
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.80561260
46MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.80150222
47TAF15_26573619_Chip-Seq_HEK293_Human1.79745885
48AR_21909140_ChIP-Seq_LNCAP_Human1.79335854
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.75383427
50EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.75352346
51IGF1R_20145208_ChIP-Seq_DFB_Human1.74932270
52FUS_26573619_Chip-Seq_HEK293_Human1.74922788
53EZH2_22144423_ChIP-Seq_EOC_Human1.74056078
54MYCN_18555785_ChIP-Seq_MESCs_Mouse1.72944551
55GBX2_23144817_ChIP-Seq_PC3_Human1.72564134
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.71092281
57POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.69714080
58* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.67709495
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.66649948
60ELK1_19687146_ChIP-ChIP_HELA_Human1.66298514
61POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65871636
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.65541772
63MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.65477330
64NANOG_18555785_ChIP-Seq_MESCs_Mouse1.64784136
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.61222642
66CTBP2_25329375_ChIP-Seq_LNCAP_Human1.60591133
67* E2F1_21310950_ChIP-Seq_MCF-7_Human1.59810490
68TP53_22573176_ChIP-Seq_HFKS_Human1.59768882
69FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.59544670
70P300_19829295_ChIP-Seq_ESCs_Human1.52651429
71SALL1_21062744_ChIP-ChIP_HESCs_Human1.49272739
72RBPJ_22232070_ChIP-Seq_NCS_Mouse1.49071803
73* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.48284288
74ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47858881
75YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46850582
76TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46634010
77PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.44939846
78CIITA_25753668_ChIP-Seq_RAJI_Human1.40162187
79ERG_20887958_ChIP-Seq_HPC-7_Mouse1.40146589
80ER_23166858_ChIP-Seq_MCF-7_Human1.39602860
81* GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.31918465
82* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.31677774
83PCGF2_27294783_Chip-Seq_ESCs_Mouse1.31540909
84FOXA1_25329375_ChIP-Seq_VCAP_Human1.30029596
85FOXA1_27270436_Chip-Seq_PROSTATE_Human1.30029596
86KDM5A_27292631_Chip-Seq_BREAST_Human1.27793122
87NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.25491227
88POU5F1_16153702_ChIP-ChIP_HESCs_Human1.24591508
89POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.24159981
90CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.23117983
91GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.22395597
92CBX2_27304074_Chip-Seq_ESCs_Mouse1.22038472
93CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.21806204
94CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21115115
95CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.19195825
96CBP_20019798_ChIP-Seq_JUKART_Human1.18883324
97IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18883324
98AR_20517297_ChIP-Seq_VCAP_Human1.18851744
99NOTCH1_21737748_ChIP-Seq_TLL_Human1.18287713
100BMI1_23680149_ChIP-Seq_NPCS_Mouse1.16721178
101MYC_18940864_ChIP-ChIP_HL60_Human1.14120928
102GATA3_21878914_ChIP-Seq_MCF-7_Human1.12397016
103SOX2_19829295_ChIP-Seq_ESCs_Human1.12175893
104NANOG_19829295_ChIP-Seq_ESCs_Human1.12175893
105ETV2_25802403_ChIP-Seq_MESCs_Mouse1.11662233
106BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.10285612
107PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09305270
108TP63_19390658_ChIP-ChIP_HaCaT_Human1.09240550
109E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08685231
110SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.07214479
111* NCOR_22424771_ChIP-Seq_293T_Human1.06510357
112TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.05280657
113ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.05244124
114ELK1_22589737_ChIP-Seq_MCF10A_Human1.03975536
115KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.00781101
116GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.00128665
117CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.99903984
118SOX2_18555785_ChIP-Seq_MESCs_Mouse0.99887953
119UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99787352
120KLF4_18555785_ChIP-Seq_MESCs_Mouse0.99631389
121STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98739142
122KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.97323153
123BCAT_22108803_ChIP-Seq_LS180_Human0.96512626
124SOX2_16153702_ChIP-ChIP_HESCs_Human0.96183642
125RNF2_27304074_Chip-Seq_NSC_Mouse0.94455202
126FOXA1_21572438_ChIP-Seq_LNCaP_Human0.94117459
127DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.93827121
128ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.93572590
129CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.93494931
130SPI1_23547873_ChIP-Seq_NB4_Human0.92981369
131PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92482014
132PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.92250835
133NFE2_27457419_Chip-Seq_LIVER_Mouse0.91491199
134HOXB7_26014856_ChIP-Seq_BT474_Human0.91335978
135AR_25329375_ChIP-Seq_VCAP_Human0.90718242
136SUZ12_27294783_Chip-Seq_NPCs_Mouse0.90544131
137HTT_18923047_ChIP-ChIP_STHdh_Human0.90426368
138TCF4_22108803_ChIP-Seq_LS180_Human0.89958818
139KLF5_20875108_ChIP-Seq_MESCs_Mouse0.88617044
140HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.88349115
141AUTS2_25519132_ChIP-Seq_293T-REX_Human0.88026735
142CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87214352
143TFEB_21752829_ChIP-Seq_HELA_Human0.87117534
144TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87041393
145POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.87041393
146POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.86978218
147MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.86952591
148SRY_22984422_ChIP-ChIP_TESTIS_Rat0.81303519
149* CTCF_18555785_ChIP-Seq_MESCs_Mouse0.79613141
150SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.79542116
151DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.79259609
152CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.78051850
153HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.76824815
154SOX17_20123909_ChIP-Seq_XEN_Mouse0.75454882
155KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.73442068
156FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73011324
157TBX5_21415370_ChIP-Seq_HL-1_Mouse0.72992643
158YY1_22570637_ChIP-Seq_MALME-3M_Human0.71633112
159MYC_22102868_ChIP-Seq_BL_Human0.69735414

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.19065769
2MP0010094_abnormal_chromosome_stability4.31159747
3MP0004957_abnormal_blastocyst_morpholog4.08856539
4MP0003111_abnormal_nucleus_morphology3.96250509
5MP0003077_abnormal_cell_cycle3.66734771
6MP0008057_abnormal_DNA_replication3.55718815
7MP0008058_abnormal_DNA_repair3.37942212
8MP0009379_abnormal_foot_pigmentation3.18543532
9MP0008007_abnormal_cellular_replicative2.92362961
10MP0003806_abnormal_nucleotide_metabolis2.82477669
11MP0002396_abnormal_hematopoietic_system2.63777008
12MP0006072_abnormal_retinal_apoptosis2.33048802
13MP0008932_abnormal_embryonic_tissue2.29095893
14MP0003195_calcinosis2.28305698
15MP0009697_abnormal_copulation2.25300981
16MP0003786_premature_aging2.25174016
17MP0002837_dystrophic_cardiac_calcinosis2.21493569
18MP0003186_abnormal_redox_activity2.19782364
19MP0003718_maternal_effect2.05852094
20MP0003136_yellow_coat_color2.02937470
21MP0005084_abnormal_gallbladder_morpholo2.02515139
22MP0000569_abnormal_digit_pigmentation1.99961605
23MP0001986_abnormal_taste_sensitivity1.98090808
24MP0004142_abnormal_muscle_tone1.96850116
25MP0008877_abnormal_DNA_methylation1.95528397
26MP0002653_abnormal_ependyma_morphology1.95052510
27MP0003123_paternal_imprinting1.90451230
28MP0005551_abnormal_eye_electrophysiolog1.89554139
29MP0002736_abnormal_nociception_after1.80396548
30MP0000490_abnormal_crypts_of1.79457658
31MP0001730_embryonic_growth_arrest1.77913892
32MP0002638_abnormal_pupillary_reflex1.73869132
33MP0004147_increased_porphyrin_level1.70664822
34MP0002132_abnormal_respiratory_system1.68212810
35MP0002277_abnormal_respiratory_mucosa1.67906472
36MP0005646_abnormal_pituitary_gland1.66544900
37MP0005253_abnormal_eye_physiology1.66107302
38MP0006036_abnormal_mitochondrial_physio1.65403588
39MP0001764_abnormal_homeostasis1.64383778
40MP0001968_abnormal_touch/_nociception1.64170397
41MP0002234_abnormal_pharynx_morphology1.63354300
42MP0003880_abnormal_central_pattern1.61563660
43MP0000350_abnormal_cell_proliferation1.60969729
44MP0008789_abnormal_olfactory_epithelium1.60859716
45MP0008875_abnormal_xenobiotic_pharmacok1.58670574
46MP0008872_abnormal_physiological_respon1.56240502
47MP0006292_abnormal_olfactory_placode1.54124475
48MP0010030_abnormal_orbit_morphology1.49696740
49MP0000631_abnormal_neuroendocrine_gland1.49448740
50MP0001485_abnormal_pinna_reflex1.48981444
51MP0002876_abnormal_thyroid_physiology1.45610737
52MP0005645_abnormal_hypothalamus_physiol1.44513211
53MP0008995_early_reproductive_senescence1.44510750
54MP0003315_abnormal_perineum_morphology1.41831656
55MP0003567_abnormal_fetal_cardiomyocyte1.41526355
56MP0006276_abnormal_autonomic_nervous1.41108902
57MP0001545_abnormal_hematopoietic_system1.39960544
58MP0005397_hematopoietic_system_phenotyp1.39960544
59MP0002210_abnormal_sex_determination1.38921980
60MP0004885_abnormal_endolymph1.38226446
61MP0000313_abnormal_cell_death1.37525869
62MP0002163_abnormal_gland_morphology1.34318376
63MP0003656_abnormal_erythrocyte_physiolo1.34051331
64MP0003646_muscle_fatigue1.32546536
65MP0002102_abnormal_ear_morphology1.28475552
66MP0001697_abnormal_embryo_size1.28425775
67MP0001929_abnormal_gametogenesis1.28160852
68MP0003283_abnormal_digestive_organ1.27918307
69MP0004808_abnormal_hematopoietic_stem1.26512191
70MP0009046_muscle_twitch1.25946801
71MP0005075_abnormal_melanosome_morpholog1.25785118
72MP0001905_abnormal_dopamine_level1.22555941
73MP0003787_abnormal_imprinting1.21588218
74MP0002080_prenatal_lethality1.21561173
75MP0002751_abnormal_autonomic_nervous1.21464972
76MP0002019_abnormal_tumor_incidence1.21233499
77MP0001145_abnormal_male_reproductive1.19620222
78MP0005380_embryogenesis_phenotype1.18571121
79MP0001672_abnormal_embryogenesis/_devel1.18571121
80MP0001293_anophthalmia1.18133595
81MP0002160_abnormal_reproductive_system1.17146913
82MP0009333_abnormal_splenocyte_physiolog1.16865269
83MP0009745_abnormal_behavioral_response1.15928775
84MP0000049_abnormal_middle_ear1.13493285
85MP0001984_abnormal_olfaction1.12340988
86MP0006035_abnormal_mitochondrial_morpho1.11122325
87MP0004043_abnormal_pH_regulation1.10764325
88MP0003984_embryonic_growth_retardation1.07062378
89MP0000427_abnormal_hair_cycle1.06528806
90MP0000653_abnormal_sex_gland1.06199091
91MP0005195_abnormal_posterior_eye1.05023410
92MP0002088_abnormal_embryonic_growth/wei1.04640579
93MP0002928_abnormal_bile_duct1.03503363
94MP0002272_abnormal_nervous_system1.03280182
95MP0004145_abnormal_muscle_electrophysio1.03215657
96MP0001853_heart_inflammation1.03075891
97MP0002095_abnormal_skin_pigmentation1.01320791
98MP0005499_abnormal_olfactory_system1.00919400
99MP0005394_taste/olfaction_phenotype1.00919400
100MP0002282_abnormal_trachea_morphology0.98430780
101MP0001119_abnormal_female_reproductive0.97893470
102MP0005389_reproductive_system_phenotype0.97884567
103MP0005379_endocrine/exocrine_gland_phen0.97180720
104MP0010352_gastrointestinal_tract_polyps0.96604991
105MP0000358_abnormal_cell_content/0.94493478
106MP0004742_abnormal_vestibular_system0.92353924
107MP0002722_abnormal_immune_system0.92034034
108MP0000689_abnormal_spleen_morphology0.91282472
109MP0002398_abnormal_bone_marrow0.91141410
110MP0005174_abnormal_tail_pigmentation0.91003011
111MP0002085_abnormal_embryonic_tissue0.89722652
112MP0003221_abnormal_cardiomyocyte_apopto0.89108546
113MP0000015_abnormal_ear_pigmentation0.88487896
114MP0000026_abnormal_inner_ear0.87420287
115MP0002557_abnormal_social/conspecific_i0.86663827
116MP0002086_abnormal_extraembryonic_tissu0.84327349
117MP0005408_hypopigmentation0.83606451
118MP0005410_abnormal_fertilization0.83036600
119MP0003937_abnormal_limbs/digits/tail_de0.82456694
120MP0000465_gastrointestinal_hemorrhage0.81858494
121MP0002752_abnormal_somatic_nervous0.81446732
122MP0002429_abnormal_blood_cell0.81161723
123MP0005266_abnormal_metabolism0.80897268
124MP0002938_white_spotting0.79916674
125MP0000858_altered_metastatic_potential0.79331515
126MP0003938_abnormal_ear_development0.78969281
127MP0005332_abnormal_amino_acid0.78801733
128MP0000778_abnormal_nervous_system0.78764167
129MP0003890_abnormal_embryonic-extraembry0.78586008
130MP0004197_abnormal_fetal_growth/weight/0.78437381
131MP0001324_abnormal_eye_pigmentation0.78410097
132MP0005391_vision/eye_phenotype0.77510568
133MP0000703_abnormal_thymus_morphology0.77426691
134MP0000647_abnormal_sebaceous_gland0.76255913
135MP0003763_abnormal_thymus_physiology0.75502875
136MP0006054_spinal_hemorrhage0.75430621
137MP0003698_abnormal_male_reproductive0.74734836
138MP0002572_abnormal_emotion/affect_behav0.73612163
139MP0004924_abnormal_behavior0.72986087
140MP0005386_behavior/neurological_phenoty0.72986087
141MP0003011_delayed_dark_adaptation0.72420761
142MP0002822_catalepsy0.72002868
143MP0001529_abnormal_vocalization0.70353257
144MP0009785_altered_susceptibility_to0.67880141
145MP0002084_abnormal_developmental_patter0.67610397
146MP0000566_synostosis0.66728729
147MP0005085_abnormal_gallbladder_physiolo0.66585597
148MP0010307_abnormal_tumor_latency0.66008969
149MP0003121_genomic_imprinting0.65676077
150MP0005360_urolithiasis0.65416087
151MP0000598_abnormal_liver_morphology0.64831246
152MP0005376_homeostasis/metabolism_phenot0.61855710
153MP0000716_abnormal_immune_system0.61696018
154MP0009672_abnormal_birth_weight0.59119183
155MP0002139_abnormal_hepatobiliary_system0.57318967
156MP0002161_abnormal_fertility/fecundity0.56918696
157MP0004133_heterotaxia0.56725953
158MP0002111_abnormal_tail_morphology0.56204334
159MP0000372_irregular_coat_pigmentation0.54217999
160MP0001919_abnormal_reproductive_system0.53773851
161MP0005636_abnormal_mineral_homeostasis0.53435378
162MP0001835_abnormal_antigen_presentation0.51967355
163MP0003436_decreased_susceptibility_to0.51173972

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.12261401
2Abnormality of cells of the erythroid lineage (HP:0012130)5.11702705
3Abnormal number of erythroid precursors (HP:0012131)4.81267625
4Birth length less than 3rd percentile (HP:0003561)4.55214229
5Aplastic anemia (HP:0001915)4.16063930
6Pancreatic cysts (HP:0001737)4.12830507
7Oral leukoplakia (HP:0002745)3.99125702
8Abnormality of midbrain morphology (HP:0002418)3.78456795
9Molar tooth sign on MRI (HP:0002419)3.78456795
10Pancreatic fibrosis (HP:0100732)3.75990975
11True hermaphroditism (HP:0010459)3.65042244
12Macrocytic anemia (HP:0001972)3.57627616
13Decreased activity of mitochondrial respiratory chain (HP:0008972)3.57050777
14Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.57050777
15Pallor (HP:0000980)3.46956101
16Rough bone trabeculation (HP:0100670)3.25903070
17Nephronophthisis (HP:0000090)3.25134047
18Breast hypoplasia (HP:0003187)3.22315146
19Hepatocellular necrosis (HP:0001404)3.21775800
20Microvesicular hepatic steatosis (HP:0001414)3.19144912
21Hepatic necrosis (HP:0002605)3.14395077
22Cerebral hypomyelination (HP:0006808)3.11860734
23Increased serum lactate (HP:0002151)3.06058455
24Colon cancer (HP:0003003)3.04704552
25Mitochondrial inheritance (HP:0001427)3.01682746
26Abnormality of the preputium (HP:0100587)2.99324411
27Aplasia/Hypoplasia of the sacrum (HP:0008517)2.98775931
28Chromsome breakage (HP:0040012)2.95452333
29Medial flaring of the eyebrow (HP:0010747)2.95103791
30Acute necrotizing encephalopathy (HP:0006965)2.93865847
31Increased serum pyruvate (HP:0003542)2.93518992
32Abnormality of glycolysis (HP:0004366)2.93518992
33Increased CSF lactate (HP:0002490)2.91091968
34Congenital stationary night blindness (HP:0007642)2.84427700
35Congenital, generalized hypertrichosis (HP:0004540)2.84311476
36Pancytopenia (HP:0001876)2.82755414
37Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.81265877
3811 pairs of ribs (HP:0000878)2.80151852
393-Methylglutaconic aciduria (HP:0003535)2.78569470
40Abnormal mitochondria in muscle tissue (HP:0008316)2.78532478
41Absent thumb (HP:0009777)2.77533238
42Meckel diverticulum (HP:0002245)2.76253447
43Chromosomal breakage induced by crosslinking agents (HP:0003221)2.75780684
44Abnormality of the renal medulla (HP:0100957)2.71064629
45Bone marrow hypocellularity (HP:0005528)2.70922253
46Increased hepatocellular lipid droplets (HP:0006565)2.68713804
47Abnormality of the heme biosynthetic pathway (HP:0010472)2.65954661
48Abnormality of the ileum (HP:0001549)2.65918898
49Premature graying of hair (HP:0002216)2.59091487
50Acute encephalopathy (HP:0006846)2.54675301
51Patellar aplasia (HP:0006443)2.53223668
52Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.53130080
53Lipid accumulation in hepatocytes (HP:0006561)2.52983257
54Type I transferrin isoform profile (HP:0003642)2.52772927
55Thrombocytosis (HP:0001894)2.51409931
56Abnormality of the renal cortex (HP:0011035)2.50701991
57Abnormality of the anterior horn cell (HP:0006802)2.48650155
58Degeneration of anterior horn cells (HP:0002398)2.48650155
59Aplasia/Hypoplasia of the patella (HP:0006498)2.47068912
60Carpal bone hypoplasia (HP:0001498)2.45037536
61Abnormality of chromosome stability (HP:0003220)2.44636494
62Type II lissencephaly (HP:0007260)2.44157233
63Hypothermia (HP:0002045)2.44019924
64Aplasia/Hypoplasia of the uvula (HP:0010293)2.43708186
65Sclerocornea (HP:0000647)2.43287505
66Secondary amenorrhea (HP:0000869)2.41612268
67Concave nail (HP:0001598)2.40948473
68Myelodysplasia (HP:0002863)2.39923438
69Methylmalonic acidemia (HP:0002912)2.36125810
70Progressive macrocephaly (HP:0004481)2.34731057
71Exercise intolerance (HP:0003546)2.33380186
72Abnormality of pyrimidine metabolism (HP:0004353)2.32305972
73Abnormal trabecular bone morphology (HP:0100671)2.29737614
74Optic disc pallor (HP:0000543)2.29097435
75Lactic acidosis (HP:0003128)2.28935862
76Abolished electroretinogram (ERG) (HP:0000550)2.27151972
77Horseshoe kidney (HP:0000085)2.26577686
78Gait imbalance (HP:0002141)2.26352915
79Cystic liver disease (HP:0006706)2.26104537
80Cellular immunodeficiency (HP:0005374)2.25725113
81Impulsivity (HP:0100710)2.25322129
82Congenital primary aphakia (HP:0007707)2.24456096
83Methylmalonic aciduria (HP:0012120)2.24153552
84Exertional dyspnea (HP:0002875)2.23496085
85Selective tooth agenesis (HP:0001592)2.23114762
86Triphalangeal thumb (HP:0001199)2.19048633
87Abnormality of reticulocytes (HP:0004312)2.19016264
88Aplasia/Hypoplasia of the tibia (HP:0005772)2.18515157
89Multiple enchondromatosis (HP:0005701)2.18514067
90Nephrogenic diabetes insipidus (HP:0009806)2.17920605
91Respiratory difficulties (HP:0002880)2.16619592
92Cleft eyelid (HP:0000625)2.16588712
93Pendular nystagmus (HP:0012043)2.16011008
94Aplasia/Hypoplasia of the tongue (HP:0010295)2.13672766
95Renal Fanconi syndrome (HP:0001994)2.13300920
96Nausea (HP:0002018)2.12774471
97Duodenal stenosis (HP:0100867)2.12494918
98Small intestinal stenosis (HP:0012848)2.12494918
99Sparse eyelashes (HP:0000653)2.12136023
100Reduced antithrombin III activity (HP:0001976)2.11253905
101Microretrognathia (HP:0000308)2.10089071
102CNS demyelination (HP:0007305)2.09643004
103Abnormal drinking behavior (HP:0030082)2.08473482
104Polydipsia (HP:0001959)2.08473482
105Muscle fiber atrophy (HP:0100295)2.07806463
106Cerebral edema (HP:0002181)2.05177477
107Anencephaly (HP:0002323)2.03151577
108Abnormal spermatogenesis (HP:0008669)2.02555104
109Short tibia (HP:0005736)2.01875282
110Inability to walk (HP:0002540)2.01207972
111Trismus (HP:0000211)2.00556506
112Lethargy (HP:0001254)1.99817955
113Neoplasm of the pancreas (HP:0002894)1.99193587
114Increased intramyocellular lipid droplets (HP:0012240)1.98950910
115Abnormal rod and cone electroretinograms (HP:0008323)1.97852376
116Tubular atrophy (HP:0000092)1.97445821
117Chronic hepatic failure (HP:0100626)1.96971990
118Abnormal protein glycosylation (HP:0012346)1.96724939
119Abnormal glycosylation (HP:0012345)1.96724939
120Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.96724939
121Abnormal protein N-linked glycosylation (HP:0012347)1.96724939
122Type 2 muscle fiber atrophy (HP:0003554)1.95916707
123Duplicated collecting system (HP:0000081)1.95400138
124Abnormality of the labia minora (HP:0012880)1.95141020
125Congenital hepatic fibrosis (HP:0002612)1.94941444
126Lissencephaly (HP:0001339)1.94641469
127Hypoplasia of the radius (HP:0002984)1.94014224
128Premature ovarian failure (HP:0008209)1.93682414
129Hyperventilation (HP:0002883)1.93527254
130Respiratory failure (HP:0002878)1.92791978
131Abnormal biliary tract physiology (HP:0012439)1.91971015
132Bile duct proliferation (HP:0001408)1.91971015
133Abnormality of the pons (HP:0007361)1.90201481
134Abnormal respiratory epithelium morphology (HP:0012253)1.89439775
135Abnormal respiratory motile cilium morphology (HP:0005938)1.89439775
136Hypoplasia of the pons (HP:0012110)1.88886790
137Severe muscular hypotonia (HP:0006829)1.88488805
138Abnormal lung lobation (HP:0002101)1.87697766
139Megaloblastic anemia (HP:0001889)1.87417197
140Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.87344815
141Abnormality of alanine metabolism (HP:0010916)1.87344815
142Hyperalaninemia (HP:0003348)1.87344815
143Postaxial foot polydactyly (HP:0001830)1.86047139
144Hyperglycinemia (HP:0002154)1.85873710
145Renal cortical cysts (HP:0000803)1.85685511
146Bilateral microphthalmos (HP:0007633)1.85672597
147Attenuation of retinal blood vessels (HP:0007843)1.85158247
148Male pseudohermaphroditism (HP:0000037)1.84624498
149Decreased electroretinogram (ERG) amplitude (HP:0000654)1.84141995
150Tracheoesophageal fistula (HP:0002575)1.83491909
151Furrowed tongue (HP:0000221)1.83153338
152Clubbing of toes (HP:0100760)1.83133366
153Aplasia/hypoplasia of the uterus (HP:0008684)1.82877358
154Abnormality of the renal collecting system (HP:0004742)1.80971873
155Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.80256400
156Medulloblastoma (HP:0002885)1.79856635
157Abnormality of urine glucose concentration (HP:0011016)1.79304478
158Glycosuria (HP:0003076)1.79304478
159Agnosia (HP:0010524)1.78410660
160Progressive muscle weakness (HP:0003323)1.78029681
161Amniotic constriction ring (HP:0009775)1.77355202
162Preaxial hand polydactyly (HP:0001177)1.77239138
163Absent/shortened dynein arms (HP:0200106)1.77215127
164Dynein arm defect of respiratory motile cilia (HP:0012255)1.77215127
165Polyuria (HP:0000103)1.75054505
166Large for gestational age (HP:0001520)1.73112950
167Genital tract atresia (HP:0001827)1.72994134
168Anophthalmia (HP:0000528)1.72081611

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.98666019
2WEE13.96241034
3EIF2AK13.90061145
4STK163.77311154
5FRK3.54165453
6VRK23.09463307
7NUAK12.83819211
8NME22.78213540
9WNK32.72548469
10CDC72.70234560
11MAP4K22.67090388
12ADRBK22.65228822
13SRPK12.58769168
14EIF2AK32.54145388
15VRK12.49637488
16ACVR1B2.43744673
17PLK42.34894762
18BRSK22.32955962
19TLK12.14503989
20TAOK32.13739136
21NEK21.95501603
22BCKDK1.93095884
23TTK1.78069492
24PLK11.75886823
25GRK11.75194880
26TSSK61.72958859
27WNK41.69558049
28MAPK131.63632621
29DYRK31.62032704
30MKNK11.60264626
31STK38L1.59003691
32BRSK11.54185111
33SCYL21.54149145
34PIM21.50331316
35NEK11.47190734
36ZAK1.46276872
37CCNB11.45378359
38AURKB1.44139439
39TESK21.40883839
40TRIM281.40365203
41PLK31.38433395
42ATR1.37505344
43TXK1.37148381
44MAP3K41.34332084
45OXSR11.25130130
46AURKA1.24219495
47CASK1.20589068
48CHEK21.17537276
49RPS6KB21.17398374
50TNIK1.16612860
51CDK71.15344122
52INSRR1.13178299
53PASK1.10771635
54EIF2AK21.06324236
55MAP3K111.04749593
56CSNK1G31.02828314
57MAP2K71.02709081
58TGFBR11.02345030
59IRAK31.02163703
60TESK10.99488980
61CSNK1G20.99382401
62EPHA20.99171658
63MKNK20.98957015
64CSNK1G10.98910961
65KDR0.98144963
66RPS6KA40.95941708
67TAF10.94865398
68PBK0.92221106
69CDK40.90736106
70DAPK20.90676181
71ADRBK10.89469052
72MAPKAPK30.89288751
73CDK80.88562804
74MAP2K30.88479232
75PAK30.87468051
76DYRK20.86441609
77STK390.84620661
78PIM10.83475522
79PDK40.82969574
80PDK30.82969574
81MST40.82475950
82MAP3K80.82120618
83NME10.80417685
84CSNK2A10.79935217
85CHEK10.79128288
86CSNK1A1L0.78767076
87IRAK40.78668647
88PRKCG0.76341995
89MAP3K30.74889836
90MAP2K60.73991238
91TAOK20.73135720
92CSNK2A20.71506782
93PHKG10.71227569
94PHKG20.71227569
95BRAF0.70999447
96PAK40.70998933
97PIK3CA0.69342157
98ABL20.68679370
99PKN10.66427407
100PNCK0.64041605
101TIE10.62594590
102MAPKAPK50.61622115
103MAPK150.61258471
104STK40.61234482
105PRKCE0.61199775
106MARK10.59604840
107BTK0.59265716
108MAP4K10.58637469
109PAK10.56574924
110ATM0.56398788
111PLK20.56398343
112STK100.55861032
113ILK0.55757118
114OBSCN0.54008037
115TEC0.52827499
116CDK20.52712107
117CAMKK20.50360318
118CSNK1A10.48151318
119BLK0.47101368
120YES10.47077456
121RPS6KA50.46579262
122PRKCQ0.45538853
123FLT30.44287663
124BCR0.41673986
125PDK20.41098441
126PRKACA0.40603919
127FGFR20.40293533
128STK240.39245434
129ERBB30.39126886
130GRK70.38918016
131MAP3K120.38131912
132NEK90.37629971
133PRKCI0.36941859
134CDK10.35981956
135PINK10.35421479
136MAPK40.34978545
137EPHA40.34900382
138LIMK10.34451494
139AKT20.31797055
140MYLK0.28548806
141LRRK20.27644979
142LYN0.26788339
143IKBKB0.26739167
144MUSK0.26596991
145RPS6KA60.26593383
146CLK10.25755101
147RPS6KC10.25356312
148RPS6KL10.25356312
149BMPR1B0.22312481
150KIT0.21621976

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.47729980
2Ribosome_Homo sapiens_hsa030104.38451762
3Proteasome_Homo sapiens_hsa030504.05273633
4Mismatch repair_Homo sapiens_hsa034303.64740152
5RNA polymerase_Homo sapiens_hsa030203.44341669
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.18763523
7Spliceosome_Homo sapiens_hsa030402.94198410
8Homologous recombination_Homo sapiens_hsa034402.71393739
9* Pyrimidine metabolism_Homo sapiens_hsa002402.66407487
10Nucleotide excision repair_Homo sapiens_hsa034202.48465334
11Base excision repair_Homo sapiens_hsa034102.46513189
12RNA transport_Homo sapiens_hsa030132.44928326
13One carbon pool by folate_Homo sapiens_hsa006702.32917813
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.18793483
15Basal transcription factors_Homo sapiens_hsa030222.04009340
16Fanconi anemia pathway_Homo sapiens_hsa034602.02850761
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.95420940
18Cell cycle_Homo sapiens_hsa041101.93475452
19Non-homologous end-joining_Homo sapiens_hsa034501.88359703
20RNA degradation_Homo sapiens_hsa030181.79891626
21Phototransduction_Homo sapiens_hsa047441.78313131
22Butanoate metabolism_Homo sapiens_hsa006501.75256554
23Folate biosynthesis_Homo sapiens_hsa007901.72524067
24Cardiac muscle contraction_Homo sapiens_hsa042601.61986841
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.58490537
26Nitrogen metabolism_Homo sapiens_hsa009101.57954263
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.53807774
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.51575240
29Parkinsons disease_Homo sapiens_hsa050121.49692437
30* Purine metabolism_Homo sapiens_hsa002301.45093503
31Sulfur relay system_Homo sapiens_hsa041221.38360764
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.35492885
33Protein export_Homo sapiens_hsa030601.35369872
34Oxidative phosphorylation_Homo sapiens_hsa001901.34895871
35Huntingtons disease_Homo sapiens_hsa050161.33025803
36Tryptophan metabolism_Homo sapiens_hsa003801.28216701
37Vitamin B6 metabolism_Homo sapiens_hsa007501.27396650
38Pentose phosphate pathway_Homo sapiens_hsa000301.24754961
39Sulfur metabolism_Homo sapiens_hsa009201.24178225
40Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.23009051
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.22512505
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.20720521
43Glutathione metabolism_Homo sapiens_hsa004801.19877662
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.17986575
45Drug metabolism - other enzymes_Homo sapiens_hsa009831.14431706
46Caffeine metabolism_Homo sapiens_hsa002321.13818312
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08801064
48p53 signaling pathway_Homo sapiens_hsa041151.08758017
49Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.02528961
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.01511128
51Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.98723467
52mRNA surveillance pathway_Homo sapiens_hsa030150.97945813
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.97720303
54Epstein-Barr virus infection_Homo sapiens_hsa051690.96599403
55Biosynthesis of amino acids_Homo sapiens_hsa012300.95671407
56Ether lipid metabolism_Homo sapiens_hsa005650.93773493
57Selenocompound metabolism_Homo sapiens_hsa004500.93544260
58Cyanoamino acid metabolism_Homo sapiens_hsa004600.91850332
59Steroid biosynthesis_Homo sapiens_hsa001000.90814823
60Nicotine addiction_Homo sapiens_hsa050330.87682350
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83901434
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.83186316
63Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.81467220
64Carbon metabolism_Homo sapiens_hsa012000.80251097
65Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.79909918
66Systemic lupus erythematosus_Homo sapiens_hsa053220.77877848
67Collecting duct acid secretion_Homo sapiens_hsa049660.77217606
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76801424
69Primary immunodeficiency_Homo sapiens_hsa053400.74710188
70Herpes simplex infection_Homo sapiens_hsa051680.73144512
71Alzheimers disease_Homo sapiens_hsa050100.67409489
72Intestinal immune network for IgA production_Homo sapiens_hsa046720.66505323
73Olfactory transduction_Homo sapiens_hsa047400.65975226
74Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.61682709
75Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.60817249
76* Metabolic pathways_Homo sapiens_hsa011000.60316129
77Legionellosis_Homo sapiens_hsa051340.59752167
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57091168
79Fructose and mannose metabolism_Homo sapiens_hsa000510.56880750
80N-Glycan biosynthesis_Homo sapiens_hsa005100.53288861
81Asthma_Homo sapiens_hsa053100.50129468
822-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.49751948
83Taste transduction_Homo sapiens_hsa047420.49635584
84Fat digestion and absorption_Homo sapiens_hsa049750.48293675
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47168492
86Arachidonic acid metabolism_Homo sapiens_hsa005900.46843079
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46419307
88Galactose metabolism_Homo sapiens_hsa000520.44404517
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41544419
90Propanoate metabolism_Homo sapiens_hsa006400.39440400
91Glycerolipid metabolism_Homo sapiens_hsa005610.39385800
92Viral carcinogenesis_Homo sapiens_hsa052030.39196381
93Fatty acid elongation_Homo sapiens_hsa000620.38833880
94Peroxisome_Homo sapiens_hsa041460.38806103
95Oocyte meiosis_Homo sapiens_hsa041140.38192779
96Pyruvate metabolism_Homo sapiens_hsa006200.37814755
97Antigen processing and presentation_Homo sapiens_hsa046120.36289715
98Fatty acid metabolism_Homo sapiens_hsa012120.35699686
99Arginine and proline metabolism_Homo sapiens_hsa003300.34799842
100Basal cell carcinoma_Homo sapiens_hsa052170.34611213
101Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.33698537
102Chemical carcinogenesis_Homo sapiens_hsa052040.33447711
103Hedgehog signaling pathway_Homo sapiens_hsa043400.33210765
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32960301
105beta-Alanine metabolism_Homo sapiens_hsa004100.32837474
106Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.32680664
107Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.32007428
108Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.28459986
109Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.28073374
110HTLV-I infection_Homo sapiens_hsa051660.27902205
111ABC transporters_Homo sapiens_hsa020100.27398627
112Morphine addiction_Homo sapiens_hsa050320.25731552
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.25450939
114Mineral absorption_Homo sapiens_hsa049780.24654613
115Regulation of autophagy_Homo sapiens_hsa041400.21339337
116Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.21219498
117Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.20430334
118Retinol metabolism_Homo sapiens_hsa008300.19655116
119Vitamin digestion and absorption_Homo sapiens_hsa049770.19153548
120Steroid hormone biosynthesis_Homo sapiens_hsa001400.18450480
121Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.17468558
122RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.17072476
123Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.16223353
124Tyrosine metabolism_Homo sapiens_hsa003500.15988328
125Fatty acid degradation_Homo sapiens_hsa000710.15922696
126Phenylalanine metabolism_Homo sapiens_hsa003600.14830023
127Linoleic acid metabolism_Homo sapiens_hsa005910.14485828
128Thyroid cancer_Homo sapiens_hsa052160.14408367
129Measles_Homo sapiens_hsa051620.11829122
130Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.11801179
131Primary bile acid biosynthesis_Homo sapiens_hsa001200.11691152
132Influenza A_Homo sapiens_hsa051640.09503142
133NOD-like receptor signaling pathway_Homo sapiens_hsa046210.09403833
134SNARE interactions in vesicular transport_Homo sapiens_hsa041300.08181413
135Shigellosis_Homo sapiens_hsa051310.07754718

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