NME2P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)7.12842154
2chaperone-mediated protein transport (GO:0072321)5.92837464
3mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.59757662
4mitochondrial respiratory chain complex I assembly (GO:0032981)5.59757662
5NADH dehydrogenase complex assembly (GO:0010257)5.59757662
6ribosomal small subunit biogenesis (GO:0042274)5.52853230
7pyrimidine deoxyribonucleotide catabolic process (GO:0009223)5.24038777
8ATP synthesis coupled proton transport (GO:0015986)5.19345483
9energy coupled proton transport, down electrochemical gradient (GO:0015985)5.19345483
10protein complex biogenesis (GO:0070271)5.12266829
11RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)5.08580736
12tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)5.08580736
13mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.98493261
14behavioral response to nicotine (GO:0035095)4.78209081
15mitochondrial respiratory chain complex assembly (GO:0033108)4.77912225
16establishment of protein localization to mitochondrial membrane (GO:0090151)4.75037102
17mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.73451990
18rRNA modification (GO:0000154)4.69101911
19DNA deamination (GO:0045006)4.68352449
20viral transcription (GO:0019083)4.63689168
21ribosome biogenesis (GO:0042254)4.58618948
22ribosomal small subunit assembly (GO:0000028)4.45376242
23ribonucleoprotein complex biogenesis (GO:0022613)4.41591666
24translational termination (GO:0006415)4.39968520
25cellular component biogenesis (GO:0044085)4.37403362
26pyrimidine nucleotide catabolic process (GO:0006244)4.37327833
27respiratory electron transport chain (GO:0022904)4.26592341
28electron transport chain (GO:0022900)4.20406136
29folic acid-containing compound biosynthetic process (GO:0009396)4.18130434
30epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)4.09619506
31homocysteine metabolic process (GO:0050667)4.00494192
32base-excision repair, AP site formation (GO:0006285)3.95254333
33SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.94911124
34pseudouridine synthesis (GO:0001522)3.90704101
35protein targeting to ER (GO:0045047)3.89365479
36cotranslational protein targeting to membrane (GO:0006613)3.88760983
37translational elongation (GO:0006414)3.88352873
38water-soluble vitamin biosynthetic process (GO:0042364)3.88136948
39purine nucleotide salvage (GO:0032261)3.86892825
40protein neddylation (GO:0045116)3.79178847
41protein-cofactor linkage (GO:0018065)3.77709836
42protein targeting to mitochondrion (GO:0006626)3.75934154
43maturation of SSU-rRNA (GO:0030490)3.71799432
44establishment of protein localization to endoplasmic reticulum (GO:0072599)3.70463369
45rRNA processing (GO:0006364)3.69551771
46protein localization to endoplasmic reticulum (GO:0070972)3.68861722
47mitochondrial RNA metabolic process (GO:0000959)3.66167609
48rRNA methylation (GO:0031167)3.64850047
49peptidyl-histidine modification (GO:0018202)3.61097598
50establishment of protein localization to mitochondrion (GO:0072655)3.57904280
51rRNA metabolic process (GO:0016072)3.55904006
52* GTP biosynthetic process (GO:0006183)3.46901412
53translation (GO:0006412)3.46643817
54* UTP metabolic process (GO:0046051)3.45543155
55DNA damage response, detection of DNA damage (GO:0042769)3.44776935
56termination of RNA polymerase III transcription (GO:0006386)3.44771737
57transcription elongation from RNA polymerase III promoter (GO:0006385)3.44771737
58chromatin remodeling at centromere (GO:0031055)3.42905709
59pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.42673279
60pteridine-containing compound biosynthetic process (GO:0042559)3.40653418
61negative regulation of DNA biosynthetic process (GO:2000279)3.37551708
62translational initiation (GO:0006413)3.32211802
63* purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.30863226
64tRNA processing (GO:0008033)3.30789990
65negative regulation of telomerase activity (GO:0051974)3.30755222
66* purine nucleoside triphosphate biosynthetic process (GO:0009145)3.30571307
67exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.27610927
68ATP biosynthetic process (GO:0006754)3.26220593
69protein localization to mitochondrion (GO:0070585)3.25866439
70cellular protein complex disassembly (GO:0043624)3.25030180
71ribosomal large subunit biogenesis (GO:0042273)3.24672302
72nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.24314079
73hydrogen ion transmembrane transport (GO:1902600)3.22135698
74viral life cycle (GO:0019058)3.21870954
75CENP-A containing nucleosome assembly (GO:0034080)3.19947211
76respiratory chain complex IV assembly (GO:0008535)3.16471260
77nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.15720395
78RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)3.15554532
79tRNA modification (GO:0006400)3.14991290
80maturation of 5.8S rRNA (GO:0000460)3.14908326
81* UTP biosynthetic process (GO:0006228)3.14686422
82ubiquinone biosynthetic process (GO:0006744)3.11692061
83cytochrome complex assembly (GO:0017004)3.10658182
84estrogen biosynthetic process (GO:0006703)3.10526613
85serine family amino acid biosynthetic process (GO:0009070)3.07078618
86* ribonucleoside triphosphate biosynthetic process (GO:0009201)3.00703589
87L-serine metabolic process (GO:0006563)3.00558797
88ncRNA processing (GO:0034470)2.99372065
89intracellular protein transmembrane import (GO:0044743)2.98158949
90L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.92173402
91positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.91034713
92regulation of telomerase activity (GO:0051972)2.89921572
93* pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.87396284
94proton transport (GO:0015992)2.81229204
95ubiquinone metabolic process (GO:0006743)2.80498487
96polyamine metabolic process (GO:0006595)2.80395745
97sulfur amino acid catabolic process (GO:0000098)2.78645455
98protein polyglutamylation (GO:0018095)2.77948004
99cysteine metabolic process (GO:0006534)2.76199389
100* guanosine-containing compound biosynthetic process (GO:1901070)2.75436731

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.04480138
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.89149970
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.80494619
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.59480815
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.36458211
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.24397302
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.10834090
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.06242489
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.80295219
10VDR_22108803_ChIP-Seq_LS180_Human2.72004592
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.23842024
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.14002977
13FOXP3_21729870_ChIP-Seq_TREG_Human2.07984948
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.07875100
15VDR_23849224_ChIP-Seq_CD4+_Human2.01269501
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse10.0662727
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.97106726
18GABP_19822575_ChIP-Seq_HepG2_Human1.90684752
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.89170917
20XRN2_22483619_ChIP-Seq_HELA_Human1.87711157
21SRF_21415370_ChIP-Seq_HL-1_Mouse1.86448644
22ELF1_17652178_ChIP-ChIP_JURKAT_Human1.82911376
23NOTCH1_21737748_ChIP-Seq_TLL_Human1.79949515
24THAP11_20581084_ChIP-Seq_MESCs_Mouse1.77014863
25CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.69192831
26TTF2_22483619_ChIP-Seq_HELA_Human1.65737876
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.62747335
28CREB1_15753290_ChIP-ChIP_HEK293T_Human1.59838835
29PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.59394522
30EZH2_22144423_ChIP-Seq_EOC_Human1.54950157
31ZNF274_21170338_ChIP-Seq_K562_Hela1.53704031
32DCP1A_22483619_ChIP-Seq_HELA_Human1.51612341
33EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.51429711
34MYC_19030024_ChIP-ChIP_MESCs_Mouse1.50990309
35CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.49884012
36EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31608916
37EWS_26573619_Chip-Seq_HEK293_Human1.30882622
38CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.30258884
39MYC_19079543_ChIP-ChIP_MESCs_Mouse1.29925932
40TP53_22573176_ChIP-Seq_HFKS_Human1.28667763
41E2F1_18555785_ChIP-Seq_MESCs_Mouse1.22143407
42NANOG_20526341_ChIP-Seq_ESCs_Human1.21725682
43* TAF2_19829295_ChIP-Seq_ESCs_Human1.21448621
44* YY1_22570637_ChIP-Seq_MALME-3M_Human1.19314444
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.18919693
46ERA_21632823_ChIP-Seq_H3396_Human1.18806491
47BMI1_23680149_ChIP-Seq_NPCS_Mouse1.18662989
48ELK1_19687146_ChIP-ChIP_HELA_Human1.17400442
49IRF1_19129219_ChIP-ChIP_H3396_Human1.17271611
50* NCOR_22424771_ChIP-Seq_293T_Human1.13803053
51MYC_18940864_ChIP-ChIP_HL60_Human1.13780344
52PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.11016843
53RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.07397215
54EED_16625203_ChIP-ChIP_MESCs_Mouse1.06098235
55SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.05298453
56EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.04391724
57CBX2_27304074_Chip-Seq_ESCs_Mouse1.01487852
58CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.01273075
59KDM5A_27292631_Chip-Seq_BREAST_Human1.01125356
60BP1_19119308_ChIP-ChIP_Hs578T_Human1.00685722
61FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.98700265
62GATA3_21878914_ChIP-Seq_MCF-7_Human0.95963844
63P53_21459846_ChIP-Seq_SAOS-2_Human0.95439947
64MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.94146826
65LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92761195
66CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.92701529
67ETV2_25802403_ChIP-Seq_MESCs_Mouse0.92496108
68GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92434590
69E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.90979213
70SRY_22984422_ChIP-ChIP_TESTIS_Rat0.87831837
71PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87501777
72* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.86461367
73* FOXA1_25329375_ChIP-Seq_VCAP_Human0.86461367
74E2F1_20622854_ChIP-Seq_HELA_Human0.85316570
75HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.85000055
76TP63_19390658_ChIP-ChIP_HaCaT_Human0.84853789
77TET1_21451524_ChIP-Seq_MESCs_Mouse0.84685263
78* CTCF_20526341_ChIP-Seq_ESCs_Human0.83384622
79HOXB4_20404135_ChIP-ChIP_EML_Mouse0.83183274
80* P300_27268052_Chip-Seq_Bcells_Human0.82639832
81EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.82487714
82HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.82308857
83JARID2_20064375_ChIP-Seq_MESCs_Mouse0.81636116
84TP53_20018659_ChIP-ChIP_R1E_Mouse0.81632947
85ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.81597282
86HOXB7_26014856_ChIP-Seq_BT474_Human0.81323279
87EZH2_27304074_Chip-Seq_ESCs_Mouse0.81119495
88PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.81095326
89FOXP1_21924763_ChIP-Seq_HESCs_Human0.80965333
90GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80932137
91* P68_20966046_ChIP-Seq_HELA_Human0.79926036
92ERG_20517297_ChIP-Seq_VCAP_Human0.79086870
93* FUS_26573619_Chip-Seq_HEK293_Human0.78321705
94KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.78000917
95FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.77877029
96MYC_19829295_ChIP-Seq_ESCs_Human0.77246414
97AUTS2_25519132_ChIP-Seq_293T-REX_Human0.76232855
98ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.75805501
99* FOXH1_21741376_ChIP-Seq_ESCs_Human0.75737921
100SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.73672716

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002736_abnormal_nociception_after3.46445982
2MP0002837_dystrophic_cardiac_calcinosis3.33139458
3MP0009379_abnormal_foot_pigmentation3.16334049
4MP0005646_abnormal_pituitary_gland3.03001217
5MP0006292_abnormal_olfactory_placode3.00864508
6MP0004885_abnormal_endolymph2.95209415
7MP0001968_abnormal_touch/_nociception2.79957795
8MP0003806_abnormal_nucleotide_metabolis2.50683451
9MP0004147_increased_porphyrin_level2.40543931
10MP0005360_urolithiasis2.34260337
11MP0002160_abnormal_reproductive_system2.24938929
12MP0008872_abnormal_physiological_respon2.23176703
13MP0001661_extended_life_span2.21351219
14MP0008058_abnormal_DNA_repair2.12489938
15MP0002938_white_spotting2.08784073
16MP0005670_abnormal_white_adipose2.00622271
17MP0002132_abnormal_respiratory_system2.00120883
18MP0000049_abnormal_middle_ear1.99596102
19MP0003646_muscle_fatigue1.97463172
20MP0002163_abnormal_gland_morphology1.83026533
21MP0006036_abnormal_mitochondrial_physio1.78548376
22MP0005389_reproductive_system_phenotype1.78282987
23MP0003186_abnormal_redox_activity1.76636902
24MP0002102_abnormal_ear_morphology1.68483072
25MP0008875_abnormal_xenobiotic_pharmacok1.67551089
26MP0005551_abnormal_eye_electrophysiolog1.66415561
27MP0002876_abnormal_thyroid_physiology1.66199262
28MP0006072_abnormal_retinal_apoptosis1.64212071
29MP0003693_abnormal_embryo_hatching1.60530841
30MP0004145_abnormal_muscle_electrophysio1.51638683
31MP0008789_abnormal_olfactory_epithelium1.49378754
32MP0002735_abnormal_chemical_nociception1.46195672
33MP0001919_abnormal_reproductive_system1.42168342
34MP0008995_early_reproductive_senescence1.40480392
35MP0000678_abnormal_parathyroid_gland1.35674083
36MP0000749_muscle_degeneration1.33787777
37MP0005253_abnormal_eye_physiology1.29700051
38MP0005332_abnormal_amino_acid1.28594345
39MP0001905_abnormal_dopamine_level1.27235215
40MP0005394_taste/olfaction_phenotype1.26033347
41MP0005499_abnormal_olfactory_system1.26033347
42MP0003786_premature_aging1.25420321
43MP0001529_abnormal_vocalization1.24291395
44MP0006276_abnormal_autonomic_nervous1.23266304
45MP0005636_abnormal_mineral_homeostasis1.23066754
46MP0002234_abnormal_pharynx_morphology1.22216378
47MP0003567_abnormal_fetal_cardiomyocyte1.21655702
48MP0000026_abnormal_inner_ear1.19461700
49MP0001764_abnormal_homeostasis1.18441582
50MP0002138_abnormal_hepatobiliary_system1.18273343
51MP0003011_delayed_dark_adaptation1.14026591
52MP0005379_endocrine/exocrine_gland_phen1.13233213
53MP0000372_irregular_coat_pigmentation1.12233259
54MP0009250_abnormal_appendicular_skeleto1.11694907
55MP0004142_abnormal_muscle_tone1.11691222
56MP0009745_abnormal_behavioral_response1.11617053
57MP0003718_maternal_effect1.09855373
58MP0000631_abnormal_neuroendocrine_gland1.09325086
59MP0004133_heterotaxia1.08330580
60MP0002272_abnormal_nervous_system1.06151733
61MP0002733_abnormal_thermal_nociception1.05303661
62MP0004043_abnormal_pH_regulation1.03039811
63MP0002184_abnormal_innervation1.01104686
64MP0001963_abnormal_hearing_physiology1.01088973
65MP0008877_abnormal_DNA_methylation1.00122502
66MP0009333_abnormal_splenocyte_physiolog0.99631012
67MP0001440_abnormal_grooming_behavior0.94645785
68MP0004130_abnormal_muscle_cell0.93960181
69MP0004742_abnormal_vestibular_system0.93609624
70MP0002229_neurodegeneration0.89995736
71MP0000566_synostosis0.89669766
72MP0002638_abnormal_pupillary_reflex0.89105136
73MP0004233_abnormal_muscle_weight0.86909962
74MP0002210_abnormal_sex_determination0.86772264
75MP0008775_abnormal_heart_ventricle0.85905269
76MP0002653_abnormal_ependyma_morphology0.85749144
77MP0001502_abnormal_circadian_rhythm0.82867664
78MP0002095_abnormal_skin_pigmentation0.82569184
79MP0005084_abnormal_gallbladder_morpholo0.82134388
80MP0003936_abnormal_reproductive_system0.81451010
81MP0003315_abnormal_perineum_morphology0.79471697
82MP0002752_abnormal_somatic_nervous0.79070130
83MP0003880_abnormal_central_pattern0.76617588
84MP0002277_abnormal_respiratory_mucosa0.76497881
85MP0001348_abnormal_lacrimal_gland0.76375858
86MP0003942_abnormal_urinary_system0.75955220
87MP0000538_abnormal_urinary_bladder0.73951279
88MP0000653_abnormal_sex_gland0.73117606
89MP0002127_abnormal_cardiovascular_syste0.72900170
90MP0005195_abnormal_posterior_eye0.72690141
91MP0000013_abnormal_adipose_tissue0.71008557
92MP0001145_abnormal_male_reproductive0.70965005
93MP0003183_abnormal_peptide_metabolism0.70448709
94MP0001270_distended_abdomen0.66193543
95MP0001970_abnormal_pain_threshold0.65321682
96MP0001485_abnormal_pinna_reflex0.63131493
97MP0001765_abnormal_ion_homeostasis0.63009757
98MP0002734_abnormal_mechanical_nocicepti0.62090895
99MP0003938_abnormal_ear_development0.60718225
100MP0010386_abnormal_urinary_bladder0.60197579

Predicted human phenotypes

RankGene SetZ-score
1Hyperalaninemia (HP:0003348)5.46581447
2Abnormality of pyruvate family amino acid metabolism (HP:0010915)5.46581447
3Abnormality of alanine metabolism (HP:0010916)5.46581447
4Acute necrotizing encephalopathy (HP:0006965)5.28382610
5Abnormal mitochondria in muscle tissue (HP:0008316)4.60941740
6Acute encephalopathy (HP:0006846)4.43567860
7Progressive macrocephaly (HP:0004481)4.31657466
8Mitochondrial inheritance (HP:0001427)4.20848131
9Increased CSF lactate (HP:0002490)3.97331356
10Constricted visual fields (HP:0001133)3.93044616
11Hepatocellular necrosis (HP:0001404)3.74514571
12Cerebral edema (HP:0002181)3.36607566
133-Methylglutaconic aciduria (HP:0003535)3.31793852
14Hepatic necrosis (HP:0002605)3.28991375
15Congenital sensorineural hearing impairment (HP:0008527)3.22757202
16Congenital stationary night blindness (HP:0007642)3.07908720
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.07304125
18Decreased activity of mitochondrial respiratory chain (HP:0008972)3.07304125
19Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.06995977
20Increased serum lactate (HP:0002151)3.00667095
21Birth length less than 3rd percentile (HP:0003561)3.00164747
22Decreased electroretinogram (ERG) amplitude (HP:0000654)2.99260795
23Absent rod-and cone-mediated responses on ERG (HP:0007688)2.95855209
24Lactic acidosis (HP:0003128)2.89003110
25Optic disc pallor (HP:0000543)2.88416046
26Abnormal rod and cone electroretinograms (HP:0008323)2.72011078
27Microretrognathia (HP:0000308)2.67535069
28Reticulocytopenia (HP:0001896)2.53405659
29Generalized aminoaciduria (HP:0002909)2.49062348
30Macrocytic anemia (HP:0001972)2.48593485
31Increased hepatocellular lipid droplets (HP:0006565)2.47599660
32Exercise intolerance (HP:0003546)2.46335608
33Renal Fanconi syndrome (HP:0001994)2.45602590
34Hyperglycinemia (HP:0002154)2.44564975
35Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.43845535
36Lipid accumulation in hepatocytes (HP:0006561)2.43202600
37Abnormality of cells of the erythroid lineage (HP:0012130)2.42497964
38Abnormal umbilical cord blood vessels (HP:0011403)2.41946097
39Single umbilical artery (HP:0001195)2.41946097
40Abnormality of the fetal cardiovascular system (HP:0010948)2.41946097
41Leukodystrophy (HP:0002415)2.37815196
42Abnormal respiratory epithelium morphology (HP:0012253)2.37253363
43Abnormal respiratory motile cilium morphology (HP:0005938)2.37253363
44Short middle phalanx of the 5th finger (HP:0004220)2.34072905
45Abnormal number of erythroid precursors (HP:0012131)2.32887539
46Conjunctival hamartoma (HP:0100780)2.30614472
47Respiratory failure (HP:0002878)2.30083874
48Lethargy (HP:0001254)2.26627001
49Oligomenorrhea (HP:0000876)2.26234012
50Abnormality of serum amino acid levels (HP:0003112)2.25580388
51Absent thumb (HP:0009777)2.24856375
52Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.21885099
53Abnormality of midbrain morphology (HP:0002418)2.21006387
54Molar tooth sign on MRI (HP:0002419)2.21006387
55Stomatitis (HP:0010280)2.16114220
56Abnormality of urine glucose concentration (HP:0011016)2.11952937
57Glycosuria (HP:0003076)2.11952937
58Pallor (HP:0000980)2.10057323
59Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.08790748
60Abnormality of the phalanges of the 5th finger (HP:0004213)2.08144188
61Patchy hypopigmentation of hair (HP:0011365)2.06639596
62Unsteady gait (HP:0002317)2.04857757
63Pendular nystagmus (HP:0012043)2.03378399
64Abnormality of the labia minora (HP:0012880)2.00022134
65Reduced antithrombin III activity (HP:0001976)1.99414126
66Exertional dyspnea (HP:0002875)1.93870407
67Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.93850881
68Ectopic kidney (HP:0000086)1.91516746
69CNS demyelination (HP:0007305)1.86595679
70Hyperphosphaturia (HP:0003109)1.85302923
71Anorexia (HP:0002039)1.84890081
72Abolished electroretinogram (ERG) (HP:0000550)1.83849715
73Cerebral hypomyelination (HP:0006808)1.83052786
74Testicular atrophy (HP:0000029)1.82781561
75Increased intramyocellular lipid droplets (HP:0012240)1.81947290
76Nausea (HP:0002018)1.81941793
77Hypoplasia of the radius (HP:0002984)1.81526135
78Pancreatic cysts (HP:0001737)1.81406320
79Cavernous hemangioma (HP:0001048)1.77988230
80Paralysis (HP:0003470)1.77263302
81Pancytopenia (HP:0001876)1.76314616
82White forelock (HP:0002211)1.74601536
83Dynein arm defect of respiratory motile cilia (HP:0012255)1.73107250
84Absent/shortened dynein arms (HP:0200106)1.73107250
85Sensory axonal neuropathy (HP:0003390)1.72861053
86Concave nail (HP:0001598)1.72057996
87Increased serum pyruvate (HP:0003542)1.70690512
88Aplasia/Hypoplasia of the sacrum (HP:0008517)1.67218346
89Abnormality of the renal collecting system (HP:0004742)1.63602060
90Double outlet right ventricle (HP:0001719)1.62662764
91Congenital malformation of the right heart (HP:0011723)1.62662764
92Supernumerary spleens (HP:0009799)1.62113829
93Abnormal drinking behavior (HP:0030082)1.62088149
94Polydipsia (HP:0001959)1.62088149
95Nephronophthisis (HP:0000090)1.62040223
96Facial hemangioma (HP:0000329)1.59644465
97Abnormality of renal resorption (HP:0011038)1.58993922
98Anencephaly (HP:0002323)1.58872137
99Increased muscle lipid content (HP:0009058)1.57958192
100Sclerocornea (HP:0000647)1.57390081

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME26.16877469
2PINK13.68270577
3WNK43.34878239
4TLK12.85994165
5VRK22.56100898
6DAPK22.31569514
7DYRK22.19710207
8OBSCN2.08882057
9ADRBK22.04852793
10BCKDK1.93882299
11PDK21.91547027
12GRK11.82222975
13NUAK11.78220812
14TIE11.72098094
15CCNB11.70930753
16MAP3K111.69846908
17PIK3CA1.60638382
18BMPR1B1.54190099
19NTRK21.49289540
20ACVR1B1.46580369
21STK161.40186828
22FRK1.37613690
23WNK31.34062935
24TXK1.34005792
25BUB11.30987992
26STK391.26646171
27NME11.19919132
28SGK4941.14717668
29SGK2231.14717668
30CDK91.13864121
31PHKG21.12518606
32PHKG11.12518606
33ADRBK11.06070200
34DAPK31.02623584
35VRK11.00120804
36RPS6KA40.99987688
37CAMK10.98018867
38MAP2K60.94354699
39PRKCG0.93871464
40ATR0.93672148
41AURKA0.92207127
42DYRK30.89238621
43RPS6KB20.85374276
44CSNK1G30.83728545
45DAPK10.83557349
46NEK20.80276847
47TAF10.80204824
48OXSR10.71942618
49GRK50.70948471
50ABL20.70409837
51MST40.69705602
52TNIK0.66210607
53CSNK1A10.65410618
54CAMK2D0.64864444
55MAP2K70.64476987
56HIPK20.64249315
57PLK10.64131926
58CSNK2A20.63487855
59MYLK0.63166937
60SGK20.61634381
61JAK30.60362538
62PRKCI0.60346018
63CDK80.60289382
64EPHB20.59364278
65RPS6KA60.59263153
66CSNK2A10.59040892
67CSNK1G20.58841968
68CAMKK20.58487291
69ILK0.58131937
70CSNK1A1L0.55971612
71CAMK1D0.54291948
72PRKG20.53870112
73ZAK0.53069783
74STK40.52767558
75RPS6KB10.52494085
76WNK10.50741678
77PBK0.49728414
78PRKCQ0.48499678
79RPS6KA50.48410763
80AURKB0.48376499
81RPS6KA10.48139316
82PLK30.47732358
83TGFBR10.47629782
84PRKACA0.46873382
85MAPKAPK50.44598078
86CHEK20.44270140
87RPS6KC10.43602199
88RPS6KL10.43602199
89FGR0.43196275
90CSNK1G10.42256841
91NEK10.40798228
92INSRR0.39726091
93CAMK2G0.39387013
94LRRK20.39337006
95MAP3K30.38969732
96BRSK10.38759622
97GRK70.37908927
98ATM0.37588580
99MUSK0.37418475
100PLK40.36725873

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.61161385
2Oxidative phosphorylation_Homo sapiens_hsa001904.14341908
3Parkinsons disease_Homo sapiens_hsa050123.37296405
4One carbon pool by folate_Homo sapiens_hsa006702.95892115
5RNA polymerase_Homo sapiens_hsa030202.77701470
6Huntingtons disease_Homo sapiens_hsa050162.40165595
7Proteasome_Homo sapiens_hsa030502.39921767
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.34773215
9Sulfur relay system_Homo sapiens_hsa041222.34738049
10Alzheimers disease_Homo sapiens_hsa050102.29192035
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.13626954
12Vitamin B6 metabolism_Homo sapiens_hsa007502.09510143
13Protein export_Homo sapiens_hsa030602.06722599
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.99015874
15Pyrimidine metabolism_Homo sapiens_hsa002401.87855423
16Cardiac muscle contraction_Homo sapiens_hsa042601.68452562
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.59182650
18Sulfur metabolism_Homo sapiens_hsa009201.57955422
19Selenocompound metabolism_Homo sapiens_hsa004501.57065659
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.55747883
21Folate biosynthesis_Homo sapiens_hsa007901.54335754
22Cysteine and methionine metabolism_Homo sapiens_hsa002701.53668254
23DNA replication_Homo sapiens_hsa030301.52201142
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.45747144
25RNA degradation_Homo sapiens_hsa030181.45406112
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.43455372
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.34017175
28Asthma_Homo sapiens_hsa053101.32955832
29Homologous recombination_Homo sapiens_hsa034401.27974426
30Fanconi anemia pathway_Homo sapiens_hsa034601.27821211
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.22784407
32Nucleotide excision repair_Homo sapiens_hsa034201.22045072
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.21031127
34Linoleic acid metabolism_Homo sapiens_hsa005911.19340834
35Collecting duct acid secretion_Homo sapiens_hsa049661.18131478
36Base excision repair_Homo sapiens_hsa034101.14164507
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.11299932
38Purine metabolism_Homo sapiens_hsa002301.10768212
39Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.04503136
40Propanoate metabolism_Homo sapiens_hsa006401.03221715
41Arginine biosynthesis_Homo sapiens_hsa002201.01351356
42Basal transcription factors_Homo sapiens_hsa030221.01219276
43Nitrogen metabolism_Homo sapiens_hsa009100.98057217
44Phototransduction_Homo sapiens_hsa047440.97838990
45Spliceosome_Homo sapiens_hsa030400.97451119
46Metabolic pathways_Homo sapiens_hsa011000.95011090
47RNA transport_Homo sapiens_hsa030130.93564315
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.93428736
49Steroid hormone biosynthesis_Homo sapiens_hsa001400.85854058
50Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.82796609
51Nicotine addiction_Homo sapiens_hsa050330.80526743
52Ether lipid metabolism_Homo sapiens_hsa005650.78135383
53Fat digestion and absorption_Homo sapiens_hsa049750.75834629
54Arginine and proline metabolism_Homo sapiens_hsa003300.75681449
55Tryptophan metabolism_Homo sapiens_hsa003800.74622615
56Peroxisome_Homo sapiens_hsa041460.72529176
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.70948600
58Intestinal immune network for IgA production_Homo sapiens_hsa046720.69658385
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.69117389
60Arachidonic acid metabolism_Homo sapiens_hsa005900.67470585
61Mismatch repair_Homo sapiens_hsa034300.66714460
62Autoimmune thyroid disease_Homo sapiens_hsa053200.66148920
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.65987554
64Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.65607001
65GABAergic synapse_Homo sapiens_hsa047270.65066046
66Pyruvate metabolism_Homo sapiens_hsa006200.64875901
67Olfactory transduction_Homo sapiens_hsa047400.64730565
68Morphine addiction_Homo sapiens_hsa050320.63688401
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.62225002
70Allograft rejection_Homo sapiens_hsa053300.61943632
71Chemical carcinogenesis_Homo sapiens_hsa052040.61841931
72Regulation of autophagy_Homo sapiens_hsa041400.60870859
73Retinol metabolism_Homo sapiens_hsa008300.60459350
74Butanoate metabolism_Homo sapiens_hsa006500.59536026
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56812742
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55644089
77Non-homologous end-joining_Homo sapiens_hsa034500.55294212
78Ovarian steroidogenesis_Homo sapiens_hsa049130.53498174
79Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.53393908
80Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52296373
81Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.49859574
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48064610
83Fatty acid biosynthesis_Homo sapiens_hsa000610.46100361
84Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43597243
85Glutathione metabolism_Homo sapiens_hsa004800.42262389
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41437480
87beta-Alanine metabolism_Homo sapiens_hsa004100.41432562
88Serotonergic synapse_Homo sapiens_hsa047260.40808065
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.39684608
90Glutamatergic synapse_Homo sapiens_hsa047240.37469534
91Steroid biosynthesis_Homo sapiens_hsa001000.37047867
92Circadian entrainment_Homo sapiens_hsa047130.33968715
93Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.32458981
94Taste transduction_Homo sapiens_hsa047420.31156680
95Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.28778785
96Mineral absorption_Homo sapiens_hsa049780.28410833
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28180264
98Starch and sucrose metabolism_Homo sapiens_hsa005000.27922513
99Rheumatoid arthritis_Homo sapiens_hsa053230.27726717
100Carbon metabolism_Homo sapiens_hsa012000.25489812

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