NLRP9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the NALP protein family. Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). This protein may play a regulatory role in the innate immune system as similar family members belong to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1multicellular organism reproduction (GO:0032504)8.76002456
2piRNA metabolic process (GO:0034587)8.61695408
3oocyte development (GO:0048599)8.50882887
4meiotic cell cycle (GO:0051321)7.97764794
5regulation of meiosis I (GO:0060631)7.92601158
6protein kinase C signaling (GO:0070528)7.37021795
7DNA methylation involved in gamete generation (GO:0043046)6.96150378
8negative regulation of reproductive process (GO:2000242)6.87049484
9positive regulation of humoral immune response (GO:0002922)6.85326103
10female gamete generation (GO:0007292)6.60994140
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)6.55618346
12regulation of histone H3-K9 methylation (GO:0051570)6.42903887
13retinal cone cell development (GO:0046549)6.41420895
14positive regulation of histone H3-K4 methylation (GO:0051571)6.40432656
15reproduction (GO:0000003)5.86188602
16regulation of steroid hormone secretion (GO:2000831)5.64262800
17negative regulation of histone methylation (GO:0031061)5.42766143
18mitotic chromosome condensation (GO:0007076)5.42231802
19binding of sperm to zona pellucida (GO:0007339)5.20029710
20gene silencing by RNA (GO:0031047)5.16791214
21positive regulation of mitotic sister chromatid separation (GO:1901970)5.13533571
22positive regulation of mitotic metaphase/anaphase transition (GO:0045842)5.13533571
23positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)5.13533571
24regulation of cell maturation (GO:1903429)5.08263275
25citrulline biosynthetic process (GO:0019240)5.00804449
26glycine transport (GO:0015816)4.87226832
27protein localization to kinetochore (GO:0034501)4.81669228
28protein localization to chromosome, centromeric region (GO:0071459)4.75056792
29fertilization (GO:0009566)4.54384481
30positive regulation of chromosome segregation (GO:0051984)4.53575168
31positive regulation of gastrulation (GO:2000543)4.43775618
32synapsis (GO:0007129)4.42287042
33positive regulation of reproductive process (GO:2000243)4.40913463
34mitotic metaphase plate congression (GO:0007080)4.34204597
35centriole replication (GO:0007099)4.32009280
36single fertilization (GO:0007338)4.28947967
37regulation of meiosis (GO:0040020)4.16274937
38establishment of chromosome localization (GO:0051303)4.08873621
39primitive streak formation (GO:0090009)4.07743170
40regulation of hypersensitivity (GO:0002883)4.07532610
41regulation of calcium ion-dependent exocytosis (GO:0017158)4.04247320
42positive regulation of histone methylation (GO:0031062)4.02278264
43sperm-egg recognition (GO:0035036)4.00753564
44DNA methylation (GO:0006306)3.97708253
45DNA alkylation (GO:0006305)3.97708253
46attachment of spindle microtubules to kinetochore (GO:0008608)3.96135901
47synaptonemal complex assembly (GO:0007130)3.94186947
48regulation of reproductive process (GO:2000241)3.87745719
49regulation of steroid hormone biosynthetic process (GO:0090030)3.86734731
50regulation of histone H3-K4 methylation (GO:0051569)3.86360139
51chromosome organization involved in meiosis (GO:0070192)3.75877459
52oogenesis (GO:0048477)3.73177818
53male meiosis I (GO:0007141)3.71197581
54regulation of phospholipid biosynthetic process (GO:0071071)3.71152498
55male meiosis (GO:0007140)3.65748384
56protein localization to chromosome (GO:0034502)3.60361001
57regulation of histone methylation (GO:0031060)3.57396104
58regulation of spindle organization (GO:0090224)3.55942103
59gene silencing (GO:0016458)3.53539606
60metaphase plate congression (GO:0051310)3.52628346
61synaptonemal complex organization (GO:0070193)3.49619032
62DNA replication checkpoint (GO:0000076)3.47979100
63N-terminal protein amino acid acetylation (GO:0006474)3.47873104
64phosphorelay signal transduction system (GO:0000160)3.46617944
65CENP-A containing nucleosome assembly (GO:0034080)3.46446972
66regulation of chromatin silencing (GO:0031935)3.45945292
67regulation of meiotic cell cycle (GO:0051445)3.44212694
68histone H3-K9 demethylation (GO:0033169)3.43965516
69negative regulation of histone modification (GO:0031057)3.37332356
70L-amino acid import (GO:0043092)3.35136920
71interkinetic nuclear migration (GO:0022027)3.33396190
72positive regulation of meiosis (GO:0045836)3.32208554
73meiotic nuclear division (GO:0007126)3.30442663
74labyrinthine layer development (GO:0060711)3.28545893
75regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.28071013
76meiotic cell cycle process (GO:1903046)3.25855977
77phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.25517966
78negative regulation of hormone biosynthetic process (GO:0032353)3.25510690
79regulation of corticosteroid hormone secretion (GO:2000846)3.22547643
80cell-cell recognition (GO:0009988)3.21141801
81DNA replication-dependent nucleosome organization (GO:0034723)3.20360956
82DNA replication-dependent nucleosome assembly (GO:0006335)3.20360956
83positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.16932329
84chromatin remodeling at centromere (GO:0031055)3.14472749
85meiosis I (GO:0007127)3.14069772
86regulation of G2/M transition of mitotic cell cycle (GO:0010389)3.10802702
87positive regulation of meiotic cell cycle (GO:0051446)3.09476558
88negative regulation of hormone metabolic process (GO:0032351)3.08980937
89phosphatidylinositol dephosphorylation (GO:0046856)3.08348353
90DNA damage induced protein phosphorylation (GO:0006975)3.06563925
91nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.06545480
92translesion synthesis (GO:0019985)3.06533273
93stress granule assembly (GO:0034063)3.06144402
94positive regulation of uterine smooth muscle contraction (GO:0070474)3.05533874
95regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.04141381
96negative regulation of cAMP-mediated signaling (GO:0043951)3.00916297
97negative regulation of chromatin modification (GO:1903309)2.99764009
98regulation of female gonad development (GO:2000194)11.3429879
99regulation of acrosome reaction (GO:0060046)11.2929071
100regulation of DNA methylation (GO:0044030)10.3528760

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.32922714
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.23834024
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.03558397
4E2F7_22180533_ChIP-Seq_HELA_Human3.95367599
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.96444209
6KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.96444209
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.96444209
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.81627470
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.66167003
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.50757367
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.27484205
12NOTCH1_21737748_ChIP-Seq_TLL_Human2.24933265
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.21889748
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.21486527
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.20282683
16EZH2_22144423_ChIP-Seq_EOC_Human16.1157555
17HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.94973130
18GBX2_23144817_ChIP-Seq_PC3_Human1.74104831
19GATA1_26923725_Chip-Seq_HPCs_Mouse1.72645864
20TP63_19390658_ChIP-ChIP_HaCaT_Human1.72576613
21E2F4_17652178_ChIP-ChIP_JURKAT_Human1.66739822
22AR_21909140_ChIP-Seq_LNCAP_Human1.59537400
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54349851
24SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47750316
25RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45878195
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40852692
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.33101838
28EP300_21415370_ChIP-Seq_HL-1_Mouse1.32034590
29BP1_19119308_ChIP-ChIP_Hs578T_Human1.31405584
30TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15076553
31TCF4_23295773_ChIP-Seq_U87_Human1.13325457
32UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12853641
33CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11807246
34CBP_20019798_ChIP-Seq_JUKART_Human1.09377741
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.09377741
36CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.08998544
37PRDM14_20953172_ChIP-Seq_ESCs_Human1.08012694
38IRF1_19129219_ChIP-ChIP_H3396_Human1.04607365
39SMAD4_21741376_ChIP-Seq_EPCs_Human1.01127584
40LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00090081
41TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.98202142
42CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.96237970
43SMAD4_21799915_ChIP-Seq_A2780_Human0.95446626
44GF1_26923725_Chip-Seq_HPCs_Mouse0.95391668
45NANOG_20526341_ChIP-Seq_ESCs_Human0.92461684
46RUNX2_22187159_ChIP-Seq_PCA_Human0.91927489
47POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91256880
48TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91256880
49FOXM1_26456572_ChIP-Seq_MCF-7_Human0.91243695
50GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.90800020
51FOXH1_21741376_ChIP-Seq_EPCs_Human0.89955953
52KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.88904541
53SALL1_21062744_ChIP-ChIP_HESCs_Human0.87640303
54GATA1_19941827_ChIP-Seq_MEL86_Mouse0.87431250
55STAT3_23295773_ChIP-Seq_U87_Human0.87259964
56* AR_25329375_ChIP-Seq_VCAP_Human0.86816404
57CBP_21632823_ChIP-Seq_H3396_Human0.86810618
58LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83631116
59PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82827737
60HTT_18923047_ChIP-ChIP_STHdh_Human0.79211550
61EWS_26573619_Chip-Seq_HEK293_Human0.78256308
62AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.78056918
63TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.77913620
64SMAD3_21741376_ChIP-Seq_EPCs_Human0.76172353
65EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.75877523
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.75435685
67KLF4_19829295_ChIP-Seq_ESCs_Human0.74751947
68PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.73239936
69SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.72964884
70SMRT_27268052_Chip-Seq_Bcells_Human0.72131648
71PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.71738343
72TAL1_26923725_Chip-Seq_HPCs_Mouse0.70629629
73SALL4_22934838_ChIP-ChIP_CD34+_Human0.70412382
74NR3C1_23031785_ChIP-Seq_PC12_Mouse0.70305833
75PKCTHETA_26484144_Chip-Seq_BREAST_Human0.69438652
76CREB1_15753290_ChIP-ChIP_HEK293T_Human0.69174397
77KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.67934271
78AHR_22903824_ChIP-Seq_MCF-7_Human0.66209821
79TP53_22573176_ChIP-Seq_HFKS_Human0.65933474
80P300_19829295_ChIP-Seq_ESCs_Human0.65248821
81MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.64915898
82BMI1_23680149_ChIP-Seq_NPCS_Mouse0.63891175
83STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.62709521
84STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.62530519
85KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.62431163
86NANOG_18555785_ChIP-Seq_MESCs_Mouse0.62239328
87ZNF274_21170338_ChIP-Seq_K562_Hela0.62127303
88ESR1_15608294_ChIP-ChIP_MCF-7_Human0.61683922
89TP53_16413492_ChIP-PET_HCT116_Human0.60990912
90SMAD3_21741376_ChIP-Seq_ESCs_Human0.60968879
91BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.59823629
92FOXP3_21729870_ChIP-Seq_TREG_Human0.59241160
93CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.58527229
94TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.58187278
95SOX2_21211035_ChIP-Seq_LN229_Gbm0.57497684
96REST_21632747_ChIP-Seq_MESCs_Mouse0.56856742
97VDR_22108803_ChIP-Seq_LS180_Human0.56568994
98AUTS2_25519132_ChIP-Seq_293T-REX_Human0.56392552
99GATA3_26560356_Chip-Seq_TH1_Human0.55906436
100FOXO3_23340844_ChIP-Seq_DLD1_Human0.55351472

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect8.84200714
2MP0008877_abnormal_DNA_methylation4.58119759
3MP0006292_abnormal_olfactory_placode4.40295603
4MP0008789_abnormal_olfactory_epithelium3.94082019
5MP0005499_abnormal_olfactory_system3.51820431
6MP0005394_taste/olfaction_phenotype3.51820431
7MP0005395_other_phenotype3.50980981
8MP0002139_abnormal_hepatobiliary_system3.12801981
9MP0008057_abnormal_DNA_replication3.09595393
10MP0003890_abnormal_embryonic-extraembry2.99775270
11MP0003693_abnormal_embryo_hatching2.91910380
12MP0003699_abnormal_female_reproductive2.80072820
13MP0002138_abnormal_hepatobiliary_system2.68313623
14MP0001929_abnormal_gametogenesis2.49288542
15MP0005360_urolithiasis2.41631038
16MP0010234_abnormal_vibrissa_follicle2.39102251
17MP0010030_abnormal_orbit_morphology2.33609019
18MP0002210_abnormal_sex_determination2.23652690
19MP0003879_abnormal_hair_cell2.20135013
20MP0008058_abnormal_DNA_repair2.19511803
21MP0003077_abnormal_cell_cycle2.11642429
22MP0002234_abnormal_pharynx_morphology2.05722145
23MP0003183_abnormal_peptide_metabolism2.05050967
24MP0010094_abnormal_chromosome_stability2.02944886
25MP0003950_abnormal_plasma_membrane2.00059685
26MP0000653_abnormal_sex_gland1.87424455
27MP0002161_abnormal_fertility/fecundity1.79400772
28MP0010368_abnormal_lymphatic_system1.74219179
29MP0003111_abnormal_nucleus_morphology1.68760616
30MP0000566_synostosis1.66146517
31MP0005410_abnormal_fertilization1.64468230
32MP0001119_abnormal_female_reproductive1.64293255
33MP0010307_abnormal_tumor_latency1.58630131
34MP0001730_embryonic_growth_arrest1.51858704
35MP0002160_abnormal_reproductive_system1.40228614
36MP0009840_abnormal_foam_cell1.37794442
37MP0001145_abnormal_male_reproductive1.33778054
38MP0008932_abnormal_embryonic_tissue1.31613741
39MP0003121_genomic_imprinting1.29944740
40MP0005389_reproductive_system_phenotype1.24656368
41MP0001293_anophthalmia1.20150846
42MP0003252_abnormal_bile_duct1.19529452
43MP0000631_abnormal_neuroendocrine_gland1.19421989
44MP0005647_abnormal_sex_gland1.17560337
45MP0003698_abnormal_male_reproductive1.13898876
46MP0000762_abnormal_tongue_morphology1.12208278
47MP0005646_abnormal_pituitary_gland1.11475416
48MP0002233_abnormal_nose_morphology1.10859331
49MP0005380_embryogenesis_phenotype1.06024596
50MP0001672_abnormal_embryogenesis/_devel1.06024596
51MP0000427_abnormal_hair_cycle1.00122812
52MP0010678_abnormal_skin_adnexa0.99026741
53MP0001984_abnormal_olfaction0.98556352
54MP0000350_abnormal_cell_proliferation0.92409692
55MP0003119_abnormal_digestive_system0.91758960
56MP0001664_abnormal_digestion0.89378584
57MP0002272_abnormal_nervous_system0.86878986
58MP0004142_abnormal_muscle_tone0.85755102
59MP0001666_abnormal_nutrient_absorption0.83962771
60MP0000678_abnormal_parathyroid_gland0.81657821
61MP0004957_abnormal_blastocyst_morpholog0.81334341
62MP0001986_abnormal_taste_sensitivity0.81120585
63MP0005551_abnormal_eye_electrophysiolog0.75398049
64MP0003868_abnormal_feces_composition0.74101594
65MP0005085_abnormal_gallbladder_physiolo0.72954280
66MP0006276_abnormal_autonomic_nervous0.69647818
67MP0001919_abnormal_reproductive_system0.68001271
68MP0001324_abnormal_eye_pigmentation0.67528974
69MP0000049_abnormal_middle_ear0.66652492
70MP0003136_yellow_coat_color0.66616489
71MP0002089_abnormal_postnatal_growth/wei0.66498982
72MP0002084_abnormal_developmental_patter0.64439253
73MP0002796_impaired_skin_barrier0.64379811
74MP0009379_abnormal_foot_pigmentation0.63798949
75MP0003959_abnormal_lean_body0.62401968
76MP0005075_abnormal_melanosome_morpholog0.54553729
77MP0005501_abnormal_skin_physiology0.54471964
78MP0001963_abnormal_hearing_physiology0.54215132
79MP0000015_abnormal_ear_pigmentation0.53357635
80MP0005076_abnormal_cell_differentiation0.52413483
81MP0002928_abnormal_bile_duct0.51601531
82MP0001502_abnormal_circadian_rhythm0.50512821
83MP0005409_darkened_coat_color0.50441203
84MP0002085_abnormal_embryonic_tissue0.49984419
85MP0002127_abnormal_cardiovascular_syste0.49942863
86MP0003941_abnormal_skin_development0.47968851
87MP0003935_abnormal_craniofacial_develop0.47337507
88MP0000383_abnormal_hair_follicle0.46916913
89MP0001697_abnormal_embryo_size0.43604476
90MP0002396_abnormal_hematopoietic_system0.43518847
91MP0000733_abnormal_muscle_development0.43168154
92MP0003984_embryonic_growth_retardation0.41717301
93MP0005319_abnormal_enzyme/_coenzyme0.38614921
94MP0002088_abnormal_embryonic_growth/wei0.38499920
95MP0002873_normal_phenotype0.37344775
96MP0002169_no_abnormal_phenotype0.36712260
97MP0000313_abnormal_cell_death0.36667655
98MP0002163_abnormal_gland_morphology0.35519726
99MP0003755_abnormal_palate_morphology0.34787605
100MP0002735_abnormal_chemical_nociception0.34412273

Predicted human phenotypes

RankGene SetZ-score
1Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)5.48616087
2Supernumerary spleens (HP:0009799)5.39575974
3Osteomalacia (HP:0002749)5.29267084
4Aplasia/Hypoplasia of the fovea (HP:0008060)5.27695583
5Hypoplasia of the fovea (HP:0007750)5.27695583
6Abnormality of abdominal situs (HP:0011620)5.13644842
7Abdominal situs inversus (HP:0003363)5.13644842
8Anterior segment dysgenesis (HP:0007700)5.01115817
9Male infertility (HP:0003251)4.82380460
10Impulsivity (HP:0100710)4.76129459
11Lip pit (HP:0100267)4.75394434
12Facial hemangioma (HP:0000329)4.75041858
13Hypophosphatemic rickets (HP:0004912)4.48487242
14Papillary thyroid carcinoma (HP:0002895)4.46108762
15Abnormality of the fovea (HP:0000493)4.45854768
16Abnormal gallbladder physiology (HP:0012438)4.43264132
17Cholecystitis (HP:0001082)4.43264132
18Infertility (HP:0000789)4.11238435
19Chromsome breakage (HP:0040012)4.06084046
20Oligodactyly (hands) (HP:0001180)4.00379863
21Chromosomal breakage induced by crosslinking agents (HP:0003221)3.97166728
22Septo-optic dysplasia (HP:0100842)3.86050317
23Azoospermia (HP:0000027)3.78155542
24Premature ovarian failure (HP:0008209)3.58094520
25Median cleft lip (HP:0000161)3.46519205
26Gonadotropin excess (HP:0000837)3.34336201
27Aplasia/Hypoplasia of the macula (HP:0008059)3.33059501
28Malnutrition (HP:0004395)3.20092938
29Apathy (HP:0000741)3.18842888
30Absent septum pellucidum (HP:0001331)3.11367865
31Abnormality of the labia minora (HP:0012880)3.09225871
32Diminished motivation (HP:0000745)3.07681177
33Aplasia/Hypoplasia affecting the retina (HP:0008061)3.04696043
34Capillary hemangiomas (HP:0005306)2.99576406
35Short tibia (HP:0005736)2.95621091
36Hypokinesia (HP:0002375)2.94542481
37Oligodactyly (HP:0012165)2.89903505
38Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.89707967
39Abnormal spermatogenesis (HP:0008669)2.87055831
40Truncal obesity (HP:0001956)2.73760200
41Hypergonadotropic hypogonadism (HP:0000815)2.66725655
42Metaphyseal irregularity (HP:0003025)2.64111360
43Abnormality of the septum pellucidum (HP:0007375)2.61594599
44Aplasia/Hypoplasia of the tibia (HP:0005772)2.59726752
45Wrist flexion contracture (HP:0001239)2.58267388
46Enlarged penis (HP:0000040)2.57946718
47Spinal cord compression (HP:0002176)2.56240841
48Urethral obstruction (HP:0000796)2.47264594
49Conjunctival telangiectasia (HP:0000524)2.45043583
50Fair hair (HP:0002286)2.44925388
51Aplasia of the musculature (HP:0100854)2.43700272
52Thyroid carcinoma (HP:0002890)2.41256782
53Lower limb hyperreflexia (HP:0002395)2.39181376
54Loss of speech (HP:0002371)2.37943365
55Myokymia (HP:0002411)2.31326305
56Generalized aminoaciduria (HP:0002909)2.30105757
57Secondary amenorrhea (HP:0000869)2.28262180
58Skin pits (HP:0100276)2.27340173
59Proximal tubulopathy (HP:0000114)2.18463113
60Aplasia/Hypoplasia of the tongue (HP:0010295)2.14664021
61Intrahepatic cholestasis (HP:0001406)2.14358127
62Anhidrosis (HP:0000970)2.13188899
63Striae distensae (HP:0001065)2.13004958
64Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.12581453
65Stillbirth (HP:0003826)2.11171115
66Maternal diabetes (HP:0009800)2.10055394
67Bundle branch block (HP:0011710)2.09449566
68Dysdiadochokinesis (HP:0002075)2.09333585
69Abnormality of the anterior chamber (HP:0000593)2.08682097
70Congenital sensorineural hearing impairment (HP:0008527)2.06071874
71Abnormal lung lobation (HP:0002101)2.05369846
72Aplasia/Hypoplasia of the uvula (HP:0010293)2.04912102
73Posterior subcapsular cataract (HP:0007787)2.04722636
74Muscle stiffness (HP:0003552)2.04644416
75Nephroblastoma (Wilms tumor) (HP:0002667)2.04066692
76Abnormality of chromosome stability (HP:0003220)2.03569682
77Heterotopia (HP:0002282)2.03305080
78Abnormality of the phalanges of the hallux (HP:0010057)1.99815037
79Rickets (HP:0002748)1.97231362
80Small intestinal stenosis (HP:0012848)1.96886642
81Duodenal stenosis (HP:0100867)1.96886642
82Abnormal ciliary motility (HP:0012262)1.96429888
83Ankle contracture (HP:0006466)1.94175869
84Abnormality of calcium-phosphate metabolism (HP:0100530)1.92403099
85Embryonal renal neoplasm (HP:0011794)1.91764404
86Bile duct proliferation (HP:0001408)1.88694362
87Abnormal biliary tract physiology (HP:0012439)1.88694362
88Meckel diverticulum (HP:0002245)1.87098044
89Subcapsular cataract (HP:0000523)1.86807469
90Abnormality of the vasculature of the conjunctiva (HP:0008054)1.85511239
91Microglossia (HP:0000171)1.85192358
92Increased circulating renin level (HP:0000848)1.84175221
93Abnormality of the preputium (HP:0100587)1.83804086
94Limb hypertonia (HP:0002509)1.82805672
95Abnormality of chromosome segregation (HP:0002916)1.81541447
96Hypercortisolism (HP:0001578)1.80934221
97Hip contracture (HP:0003273)1.80843711
98Abnormality of the ileum (HP:0001549)1.77063680
99Neoplasm of the oral cavity (HP:0100649)1.76154685
100Hydroureter (HP:0000072)1.74099902

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K96.24470351
2MAP3K135.59264801
3ARAF5.58962316
4CDK123.53203410
5TTK3.25129344
6STK243.10062508
7NEK63.06541257
8BRAF2.98840417
9TAOK32.92215016
10AURKA2.45274132
11MOS2.42412721
12CDK92.33006330
13MET2.32218392
14CDC72.06010249
15KSR21.97176126
16RAF11.81550765
17NTRK21.79106127
18PRKCI1.54313583
19MELK1.48035343
20CDK71.45556961
21PLK11.40418299
22STK31.35613862
23EIF2AK31.29984135
24TRIM281.29592368
25TNIK1.23071235
26BRSK11.18778393
27KSR11.17860741
28BUB11.06572288
29CHEK10.98237841
30MAP3K80.98130930
31WNK10.96662985
32ZAK0.96566439
33PTK20.93843766
34PIM10.93547330
35CDK190.89524304
36MST40.89466120
37ACVR1B0.86994660
38CDK80.84878914
39NEK20.84182553
40NEK90.82772795
41CHEK20.77882438
42NUAK10.76842709
43CDK20.76424881
44TGFBR10.75452523
45CAMK1D0.73174488
46AURKB0.72973591
47STK390.70828177
48TIE10.69666630
49CSNK1G10.69247386
50ATM0.67730775
51TNK20.63766673
52MARK30.63613828
53PLK30.62398076
54BMPR1B0.59787593
55DMPK0.59159180
56MTOR0.57392360
57CSNK1D0.56056547
58CDK10.54873712
59BRSK20.54691891
60NTRK30.54296891
61PAK10.52869998
62PRKG10.51201939
63CAMK1G0.49733122
64BRD40.49464269
65MAPKAPK30.48448887
66LMTK20.48076927
67EEF2K0.47039486
68ATR0.46516504
69PLK40.44295031
70PRKCZ0.44011180
71CSNK1G30.41989406
72PKN10.41566086
73CSNK1E0.37523171
74MAPK130.36625438
75PBK0.35887497
76TYRO30.33820466
77FLT30.32486515
78CDK50.31973094
79GSK3B0.29993549
80PRKACB0.29888728
81CSNK1G20.29144598
82CAMK2A0.28789006
83VRK10.28616920
84MAPK10.28529474
85LRRK20.27677047
86PRKACA0.26585721
87PDK10.24941996
88CHUK0.24670140
89SRPK10.23965727
90MAP3K50.23863016
91CSNK1A1L0.23560274
92CLK10.20629215
93MAPK100.20097734
94EPHA40.19853512
95AKT20.18533286
96TLK10.18500939
97MAPK110.17950369
98MAP3K70.17816424
99MARK20.14682980
100CAMK40.14548305

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030225.04519002
2Cell cycle_Homo sapiens_hsa041104.49613086
3Mismatch repair_Homo sapiens_hsa034304.01803068
4Ovarian steroidogenesis_Homo sapiens_hsa049133.90507168
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.47454970
6Oocyte meiosis_Homo sapiens_hsa041143.35792236
7Dorso-ventral axis formation_Homo sapiens_hsa043202.88938383
8Base excision repair_Homo sapiens_hsa034102.88794815
9RNA degradation_Homo sapiens_hsa030182.69091573
10DNA replication_Homo sapiens_hsa030302.65302406
11Caffeine metabolism_Homo sapiens_hsa002322.64741361
12Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.61736716
13Nucleotide excision repair_Homo sapiens_hsa034202.35274914
14Fanconi anemia pathway_Homo sapiens_hsa034602.34002756
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.28407278
16Homologous recombination_Homo sapiens_hsa034402.15072267
17RNA transport_Homo sapiens_hsa030131.95916342
18Cysteine and methionine metabolism_Homo sapiens_hsa002701.93883245
19Circadian rhythm_Homo sapiens_hsa047101.84091036
20Olfactory transduction_Homo sapiens_hsa047401.79351696
21p53 signaling pathway_Homo sapiens_hsa041151.72326574
22Gap junction_Homo sapiens_hsa045401.72015189
23Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.68249327
24Folate biosynthesis_Homo sapiens_hsa007901.56243536
25Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.54995610
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.43214885
27Thyroid cancer_Homo sapiens_hsa052161.32685561
28Phototransduction_Homo sapiens_hsa047441.26985112
29Inositol phosphate metabolism_Homo sapiens_hsa005621.23923175
30mRNA surveillance pathway_Homo sapiens_hsa030151.22782895
31RNA polymerase_Homo sapiens_hsa030201.05046622
32ABC transporters_Homo sapiens_hsa020101.03677425
33Phosphatidylinositol signaling system_Homo sapiens_hsa040700.98803628
34Nicotine addiction_Homo sapiens_hsa050330.94277559
35TGF-beta signaling pathway_Homo sapiens_hsa043500.92939800
36mTOR signaling pathway_Homo sapiens_hsa041500.92053385
37SNARE interactions in vesicular transport_Homo sapiens_hsa041300.89013242
38Bile secretion_Homo sapiens_hsa049760.87203239
39GABAergic synapse_Homo sapiens_hsa047270.77357833
40Morphine addiction_Homo sapiens_hsa050320.73823072
41Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66852116
42FoxO signaling pathway_Homo sapiens_hsa040680.62500993
43MicroRNAs in cancer_Homo sapiens_hsa052060.60143016
44Long-term depression_Homo sapiens_hsa047300.60097390
45Synaptic vesicle cycle_Homo sapiens_hsa047210.59983498
46Taste transduction_Homo sapiens_hsa047420.59290686
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58815661
48Fatty acid elongation_Homo sapiens_hsa000620.53260235
49Purine metabolism_Homo sapiens_hsa002300.52082098
50Adherens junction_Homo sapiens_hsa045200.51204700
51Serotonergic synapse_Homo sapiens_hsa047260.45403399
52Regulation of autophagy_Homo sapiens_hsa041400.44824137
53Herpes simplex infection_Homo sapiens_hsa051680.41686747
54Non-homologous end-joining_Homo sapiens_hsa034500.41445546
55Viral carcinogenesis_Homo sapiens_hsa052030.40547351
56Aldosterone synthesis and secretion_Homo sapiens_hsa049250.39981356
57Notch signaling pathway_Homo sapiens_hsa043300.38156762
58Vitamin digestion and absorption_Homo sapiens_hsa049770.37284416
59Wnt signaling pathway_Homo sapiens_hsa043100.37231422
60Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.36328770
61Glycosaminoglycan degradation_Homo sapiens_hsa005310.36183721
62ErbB signaling pathway_Homo sapiens_hsa040120.34927893
63Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33434401
64Hippo signaling pathway_Homo sapiens_hsa043900.32843940
65HTLV-I infection_Homo sapiens_hsa051660.32837757
66Small cell lung cancer_Homo sapiens_hsa052220.31872207
67Ras signaling pathway_Homo sapiens_hsa040140.29832102
68Lysine degradation_Homo sapiens_hsa003100.29585899
69Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.29460398
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.28275780
71cGMP-PKG signaling pathway_Homo sapiens_hsa040220.22185994
72cAMP signaling pathway_Homo sapiens_hsa040240.20728125
73Phagosome_Homo sapiens_hsa041450.17563617
74Protein digestion and absorption_Homo sapiens_hsa049740.17244647
75Oxytocin signaling pathway_Homo sapiens_hsa049210.17171771
76Renal cell carcinoma_Homo sapiens_hsa052110.16773304
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.16716052
78Endometrial cancer_Homo sapiens_hsa052130.16703391
79Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.15540902
80Huntingtons disease_Homo sapiens_hsa050160.15129272
81Long-term potentiation_Homo sapiens_hsa047200.14951387
82Vitamin B6 metabolism_Homo sapiens_hsa007500.14501502
83Arginine biosynthesis_Homo sapiens_hsa002200.13932647
84Cholinergic synapse_Homo sapiens_hsa047250.13490354
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.12969883
86Maturity onset diabetes of the young_Homo sapiens_hsa049500.11482044
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.11277957
88HIF-1 signaling pathway_Homo sapiens_hsa040660.10825889
89Pyrimidine metabolism_Homo sapiens_hsa002400.10631150
90Circadian entrainment_Homo sapiens_hsa047130.09161968
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.09100470
92Prostate cancer_Homo sapiens_hsa052150.09061002
93PI3K-Akt signaling pathway_Homo sapiens_hsa041510.07847423
94MAPK signaling pathway_Homo sapiens_hsa040100.07751670
95Spliceosome_Homo sapiens_hsa030400.06977474
96Melanogenesis_Homo sapiens_hsa049160.06852130
97Insulin signaling pathway_Homo sapiens_hsa049100.06701319
98Arginine and proline metabolism_Homo sapiens_hsa003300.06075878
99Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.05587633
100Pathways in cancer_Homo sapiens_hsa052000.05398545

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