NLRP6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene binds arginine-vasopressin and may be involved in the arginine-vasopressin-mediated regulation of renal salt-water balance. The encoded protein also mediates inflammatory responses in the colon to allow recovery from intestinal epithelial damage and protects against tumorigenesis and the development of colitis. Finally, this protein can increase activation of NF-kappa-B, activation of CASP1 through interaction with ASC, and cAMP accumulation. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.37970987
2L-phenylalanine catabolic process (GO:0006559)7.37970987
3L-phenylalanine metabolic process (GO:0006558)7.11188947
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.11188947
5aromatic amino acid family catabolic process (GO:0009074)6.65918336
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.16545964
7tryptophan catabolic process (GO:0006569)6.09956885
8indole-containing compound catabolic process (GO:0042436)6.09956885
9indolalkylamine catabolic process (GO:0046218)6.09956885
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.04344455
11positive regulation of gamma-delta T cell activation (GO:0046645)5.93546092
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.92773120
13angiotensin maturation (GO:0002003)5.91624219
14kynurenine metabolic process (GO:0070189)5.89301970
15tryptophan metabolic process (GO:0006568)5.72856001
16glyoxylate metabolic process (GO:0046487)5.69712574
17antigen processing and presentation of endogenous antigen (GO:0019883)5.68570793
18bile acid biosynthetic process (GO:0006699)5.62804539
19negative regulation of cell killing (GO:0031342)5.58797461
20negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.58797461
21antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.58404898
22urea cycle (GO:0000050)5.54903770
23urea metabolic process (GO:0019627)5.54903770
24cysteine metabolic process (GO:0006534)5.41738020
25alpha-linolenic acid metabolic process (GO:0036109)5.34545430
26sulfur amino acid catabolic process (GO:0000098)5.28751712
27high-density lipoprotein particle remodeling (GO:0034375)5.26450701
28nitrogen cycle metabolic process (GO:0071941)5.09791407
29negative regulation of fibrinolysis (GO:0051918)5.03607901
30serine family amino acid catabolic process (GO:0009071)5.01238909
31homocysteine metabolic process (GO:0050667)5.00973219
32tolerance induction (GO:0002507)4.96691212
33bile acid metabolic process (GO:0008206)4.93523791
34protein carboxylation (GO:0018214)4.92380415
35peptidyl-glutamic acid carboxylation (GO:0017187)4.92380415
36fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.91614354
37regulation of fibrinolysis (GO:0051917)4.88576273
38regulation of protein activation cascade (GO:2000257)4.86156377
39aromatic amino acid family metabolic process (GO:0009072)4.85393187
40regulation of gamma-delta T cell differentiation (GO:0045586)4.84805152
41regulation of triglyceride catabolic process (GO:0010896)4.84465385
42complement activation, alternative pathway (GO:0006957)4.84084328
43lysine metabolic process (GO:0006553)4.78566353
44lysine catabolic process (GO:0006554)4.78566353
45regulation of cholesterol esterification (GO:0010872)4.76420640
46regulation of gamma-delta T cell activation (GO:0046643)4.67219868
47positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.63863760
48drug catabolic process (GO:0042737)4.63730240
49cellular ketone body metabolic process (GO:0046950)4.63587543
50reverse cholesterol transport (GO:0043691)4.63429403
51negative regulation of sterol transport (GO:0032372)4.61896288
52negative regulation of cholesterol transport (GO:0032375)4.61896288
53acylglycerol homeostasis (GO:0055090)4.60233416
54triglyceride homeostasis (GO:0070328)4.60233416
55amino-acid betaine metabolic process (GO:0006577)4.58997498
56protein-lipid complex remodeling (GO:0034368)4.54955997
57macromolecular complex remodeling (GO:0034367)4.54955997
58plasma lipoprotein particle remodeling (GO:0034369)4.54955997
59alpha-amino acid catabolic process (GO:1901606)4.53369416
60regulation of complement activation (GO:0030449)4.53080493
61phospholipid efflux (GO:0033700)4.52671701
62bile acid and bile salt transport (GO:0015721)4.52597762
63tyrosine metabolic process (GO:0006570)4.50884341
64regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.42540696
65cellular glucuronidation (GO:0052695)4.37111386
66indolalkylamine metabolic process (GO:0006586)4.31942310
67regulation of cellular extravasation (GO:0002691)4.28838726
68glutamate metabolic process (GO:0006536)4.27310108
69regulation of bile acid biosynthetic process (GO:0070857)4.27235814
70positive regulation by symbiont of host defense response (GO:0052509)4.24224250
71modulation by symbiont of host defense response (GO:0052031)4.24224250
72modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.24224250
73modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.24224250
74positive regulation by organism of defense response of other organism involved in symbiotic interact4.24224250
75modulation by symbiont of host immune response (GO:0052553)4.24224250
76cellular biogenic amine catabolic process (GO:0042402)4.22022376
77amine catabolic process (GO:0009310)4.22022376
78cellular amino acid catabolic process (GO:0009063)4.21033930
79coenzyme catabolic process (GO:0009109)4.20346114
80glycine metabolic process (GO:0006544)4.20229110
81imidazole-containing compound metabolic process (GO:0052803)4.15014189
82cholesterol efflux (GO:0033344)4.14423107
83serine family amino acid metabolic process (GO:0009069)4.13227726
84intestinal cholesterol absorption (GO:0030299)4.12763791
85cellular modified amino acid catabolic process (GO:0042219)4.12747052
86detection of other organism (GO:0098543)4.12713920
87benzene-containing compound metabolic process (GO:0042537)4.09506318
88flavonoid metabolic process (GO:0009812)4.07413321
89plasma lipoprotein particle clearance (GO:0034381)4.06711042
90plasma lipoprotein particle assembly (GO:0034377)4.03209802
91detection of bacterium (GO:0016045)4.03145902
92ethanol oxidation (GO:0006069)4.01890699
93ketone body metabolic process (GO:1902224)4.00828165
94regulation of cholesterol homeostasis (GO:2000188)4.00035337
95serine family amino acid biosynthetic process (GO:0009070)3.99057872
96antigen processing and presentation via MHC class Ib (GO:0002475)3.98112624
97drug transmembrane transport (GO:0006855)3.96633908
98exogenous drug catabolic process (GO:0042738)3.94196831
99glucuronate metabolic process (GO:0019585)3.91565522
100uronic acid metabolic process (GO:0006063)3.91565522
101regulation of guanylate cyclase activity (GO:0031282)3.90203336
102arginine metabolic process (GO:0006525)3.90088092
103fat-soluble vitamin biosynthetic process (GO:0042362)3.88984944
104positive regulation of triglyceride lipase activity (GO:0061365)3.86288079
105positive regulation of lipoprotein lipase activity (GO:0051006)3.86288079
106short-chain fatty acid metabolic process (GO:0046459)3.85334035
107aldehyde catabolic process (GO:0046185)3.84831567
108cholesterol homeostasis (GO:0042632)3.84297124
109very-low-density lipoprotein particle assembly (GO:0034379)3.82648556
110urate metabolic process (GO:0046415)3.81275429
111dicarboxylic acid biosynthetic process (GO:0043650)3.80644797
112sterol homeostasis (GO:0055092)3.79431570
113phospholipid homeostasis (GO:0055091)3.73682387
114organic acid catabolic process (GO:0016054)3.70798230
115carboxylic acid catabolic process (GO:0046395)3.70798230
116immunoglobulin mediated immune response (GO:0016064)3.70100709
117low-density lipoprotein particle remodeling (GO:0034374)3.69484429
118drug metabolic process (GO:0017144)3.63821332
119acetyl-CoA metabolic process (GO:0006084)3.63649276
120positive regulation of lipid catabolic process (GO:0050996)3.62944522
121fibrinolysis (GO:0042730)3.62109161
122protein-lipid complex assembly (GO:0065005)3.61864559
123cofactor catabolic process (GO:0051187)3.56961060
124response to interleukin-15 (GO:0070672)3.56622238
125plasma lipoprotein particle organization (GO:0071827)3.53443856
126lipoprotein metabolic process (GO:0042157)3.53413193
127macrophage activation involved in immune response (GO:0002281)3.51875789
128response to nitrosative stress (GO:0051409)3.50993009
129lipoprotein transport (GO:0042953)3.46354796
130regulation of B cell receptor signaling pathway (GO:0050855)3.44463087
131neutrophil activation involved in immune response (GO:0002283)3.39199837
132regulation of dendritic cell antigen processing and presentation (GO:0002604)3.38745964
133regulation of interferon-beta biosynthetic process (GO:0045357)3.38524807
134detection of external biotic stimulus (GO:0098581)3.36313055
135negative regulation of lymphocyte mediated immunity (GO:0002707)3.33894351
136cellular response to interleukin-15 (GO:0071350)3.24474945
137defense response to protozoan (GO:0042832)3.16262562
138dendritic cell chemotaxis (GO:0002407)3.13908832
139cellular extravasation (GO:0045123)3.12569218
140type I interferon signaling pathway (GO:0060337)3.10239595
141cellular response to type I interferon (GO:0071357)3.10239595
142response to type I interferon (GO:0034340)3.10127603
143B cell receptor signaling pathway (GO:0050853)3.09327880
144leukocyte aggregation (GO:0070486)3.09258144
145diacylglycerol metabolic process (GO:0046339)3.09124249
146positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.07836774
147hormone catabolic process (GO:0042447)3.05089460
148respiratory burst (GO:0045730)3.04537732
149maintenance of gastrointestinal epithelium (GO:0030277)3.01789624
150actin filament depolymerization (GO:0030042)3.01510599
151dendritic cell migration (GO:0036336)2.98864004
152neutrophil activation (GO:0042119)2.97586029
153NADH metabolic process (GO:0006734)2.97389459
154intestinal absorption (GO:0050892)2.95083440
155negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.94915967
156interferon-gamma-mediated signaling pathway (GO:0060333)2.92430527
157negative regulation of leukocyte mediated immunity (GO:0002704)2.90989358
158negative regulation of interleukin-12 production (GO:0032695)2.89872459
159positive regulation of Cdc42 GTPase activity (GO:0043089)2.88916311
160regulation of T cell mediated cytotoxicity (GO:0001914)2.88642154
161detection of biotic stimulus (GO:0009595)2.84487910
162epoxygenase P450 pathway (GO:0019373)2.84252386
163regulation of T cell tolerance induction (GO:0002664)2.83421018
164negative T cell selection (GO:0043383)2.81822812
165positive regulation of T cell mediated cytotoxicity (GO:0001916)2.81773814
166negative thymic T cell selection (GO:0045060)2.81562525
167NIK/NF-kappaB signaling (GO:0038061)2.81533456
168detection of molecule of bacterial origin (GO:0032490)2.81498987
169cellular response to reactive nitrogen species (GO:1902170)2.81382042
170leukotriene metabolic process (GO:0006691)2.79968835
171peptide catabolic process (GO:0043171)2.77945976
172positive regulation of T cell differentiation in thymus (GO:0033089)2.77234590
173B cell mediated immunity (GO:0019724)2.76776140
174positive regulation of guanylate cyclase activity (GO:0031284)2.76494469
175positive regulation of antigen processing and presentation (GO:0002579)2.76485378
176fructose metabolic process (GO:0006000)2.76192760
177positive thymic T cell selection (GO:0045059)2.75266316
178germinal center formation (GO:0002467)2.73414677
179negative regulation of glycoprotein biosynthetic process (GO:0010561)2.73357964
180regulation of systemic arterial blood pressure by hormone (GO:0001990)2.73161659
181regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.73161659
182endocrine process (GO:0050886)2.73161659
183response to host immune response (GO:0052572)2.70265685
184response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.70265685
185regulation of natural killer cell mediated immunity (GO:0002715)2.65295428
186regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.65295428
187regulation of antigen processing and presentation (GO:0002577)2.64945395
188response to protozoan (GO:0001562)2.64201812
189cytidine metabolic process (GO:0046087)2.63562015
190cytidine catabolic process (GO:0006216)2.63562015
191cytidine deamination (GO:0009972)2.63562015
192regulation of leukocyte mediated cytotoxicity (GO:0001910)2.63487994
193granulocyte activation (GO:0036230)2.61957558
194positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.61117471
195T cell costimulation (GO:0031295)2.60544942
196regulation of regulatory T cell differentiation (GO:0045589)2.59858090
197lymphocyte costimulation (GO:0031294)2.59374199
198pyrimidine ribonucleoside catabolic process (GO:0046133)2.59305110
199negative regulation of T cell mediated immunity (GO:0002710)2.57904179

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.25037409
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.20053020
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.75584235
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.40899778
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.09724776
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.85971309
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.83235937
8BP1_19119308_ChIP-ChIP_Hs578T_Human4.09009747
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.95250178
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.77515189
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.51019454
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.39900092
13IRF8_21731497_ChIP-ChIP_J774_Mouse3.39586969
14* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.72915287
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.51837132
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.50123712
17VDR_21846776_ChIP-Seq_THP-1_Human2.45007611
18HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.44694033
19IRF8_27001747_Chip-Seq_BMDM_Mouse2.40667572
20VDR_24763502_ChIP-Seq_THP-1_Human2.37998205
21RUNX_20019798_ChIP-Seq_JUKART_Human2.35922056
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.16547729
23E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.15417741
24RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.11820210
25VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.11231699
26* MYB_26560356_Chip-Seq_TH2_Human2.11099685
27MAF_26560356_Chip-Seq_TH1_Human2.09673872
28IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.06820693
29TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.05896461
30UTX_26944678_Chip-Seq_JUKART_Human2.01287743
31ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.6407359
32STAT4_19710469_ChIP-ChIP_TH1__Mouse1.95901687
33SPI1_23547873_ChIP-Seq_NB4_Human1.94334959
34RUNX1_22412390_ChIP-Seq_EML_Mouse1.94064532
35TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91435883
36FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.88863288
37MYB_21317192_ChIP-Seq_ERMYB_Mouse1.86068730
38SPI1_23127762_ChIP-Seq_K562_Human1.85175704
39* MYB_26560356_Chip-Seq_TH1_Human1.80143180
40TCF7_22412390_ChIP-Seq_EML_Mouse1.74588484
41MYC_22102868_ChIP-Seq_BL_Human1.72581261
42KDM2B_26808549_Chip-Seq_SUP-B15_Human1.72087610
43SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.70719129
44SCL_19346495_ChIP-Seq_HPC-7_Human1.67230096
45BRD4_27068464_Chip-Seq_AML-cells_Mouse1.65186015
46FOXA2_19822575_ChIP-Seq_HepG2_Human1.64350432
47CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.55733694
48HNF4A_19822575_ChIP-Seq_HepG2_Human1.54634931
49KDM2B_26808549_Chip-Seq_DND41_Human1.52810191
50VDR_24787735_ChIP-Seq_THP-1_Human1.50276754
51CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.47465224
52CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.45876094
53ELK3_25401928_ChIP-Seq_HUVEC_Human1.44965933
54STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.44828058
55GATA2_22383799_ChIP-Seq_G1ME_Mouse1.44709269
56* MAF_26560356_Chip-Seq_TH2_Human1.43925404
57SOX2_27498859_Chip-Seq_STOMACH_Mouse1.41913886
58CLOCK_20551151_ChIP-Seq_293T_Human1.41314784
59GATA3_27048872_Chip-Seq_THYMUS_Human1.40741513
60HTT_18923047_ChIP-ChIP_STHdh_Human1.40662272
61KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.39691970
62NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.37372795
63KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.37254626
64BCL6_27268052_Chip-Seq_Bcells_Human1.34334977
65GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.33554951
66TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.33340694
67GATA1_22025678_ChIP-Seq_K562_Human1.32894161
68CDX2_20551321_ChIP-Seq_CACO-2_Human1.31811442
69BCOR_27268052_Chip-Seq_Bcells_Human1.30213401
70GATA1_22383799_ChIP-Seq_G1ME_Mouse1.28642704
71THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.26967282
72MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.24512194
73GATA4_25053715_ChIP-Seq_YYC3_Human1.24153144
74* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.23191909
75ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.21318307
76PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20893084
77RXRA_24833708_ChIP-Seq_LIVER_Mouse1.16586900
78IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.16483009
79TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.15789530
80PU.1_20513432_ChIP-Seq_Bcells_Mouse1.14533316
81SMAD_19615063_ChIP-ChIP_OVARY_Human1.12635099
82LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10834837
83GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08877966
84PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08616341
85GATA3_26560356_Chip-Seq_TH2_Human1.08443827
86CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08178276
87PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07420221
88STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.07242485
89GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06723216
90SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05853437
91* SA1_27219007_Chip-Seq_Bcells_Human1.03195565
92CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03030838
93SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.01806662
94KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01360871
95GATA2_21666600_ChIP-Seq_HMVEC_Human1.00424132
96PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99496999
97* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.99432747
98TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96675918
99VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.95890427
100NCOR1_26117541_ChIP-Seq_K562_Human0.95063081
101* SA1_27219007_Chip-Seq_ERYTHROID_Human0.93761467
102ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.91892385
103ESR1_15608294_ChIP-ChIP_MCF-7_Human0.87817487
104RARG_19884340_ChIP-ChIP_MEFs_Mouse0.87435074
105KAP1_22055183_ChIP-Seq_ESCs_Mouse0.86999956
106ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.86204213
107PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.85232132
108NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.83371214
109GATA6_25053715_ChIP-Seq_YYC3_Human0.82661439
110IRF8_22096565_ChIP-ChIP_GC-B_Human0.82201781
111AUTS2_25519132_ChIP-Seq_293T-REX_Human0.80309067
112ESR2_21235772_ChIP-Seq_MCF-7_Human0.78865519
113RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.78590263
114BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.77130187
115SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.76843140
116RARA_24833708_ChIP-Seq_LIVER_Mouse0.75919942
117AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.75643351
118BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.72958423
119ZNF263_19887448_ChIP-Seq_K562_Human0.72675866
120TP63_17297297_ChIP-ChIP_HaCaT_Human0.70991765
121SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.69443203
122RAD21_21589869_ChIP-Seq_MESCs_Mouse0.68747376
123SALL4_18804426_ChIP-ChIP_XEN_Mouse0.68447365
124ESR1_21235772_ChIP-Seq_MCF-7_Human0.65728041
125Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.65534040
126SOX2_20726797_ChIP-Seq_SW620_Human0.64635985
127CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.64632801
128CEBPB_22108803_ChIP-Seq_LS180_Human0.62247382
129STAT3_1855785_ChIP-Seq_MESCs_Mouse0.62157703
130RARB_24833708_ChIP-Seq_LIVER_Mouse0.62048660
131LXR_22292898_ChIP-Seq_THP-1_Human0.60047437
132FOXO3_23340844_ChIP-Seq_DLD1_Human0.59712504
133FOXA1_25552417_ChIP-Seq_VCAP_Human0.59419930
134* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.58777969
135MYC_19915707_ChIP-ChIP_AK7_Human0.57635327
136AR_20517297_ChIP-Seq_VCAP_Human0.57549700
137FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.56403458
138NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.56390820
139FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.56299276
140PPAR_26484153_Chip-Seq_NCI-H1993_Human0.56095897
141EGR1_19032775_ChIP-ChIP_M12_Human0.55252617
142NRF2_20460467_ChIP-Seq_MEFs_Mouse0.55030669
143NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.55030669
144FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.54311127
145STAT1_17558387_ChIP-Seq_HELA_Human0.54011742
146PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.53990843
147PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.52632585
148ESET_19884257_ChIP-Seq_ESCs_Mouse0.49966119
149P53_21459846_ChIP-Seq_SAOS-2_Human0.49193793
150* CBP_21632823_ChIP-Seq_H3396_Human0.47225334
151GATA2_19941826_ChIP-Seq_K562_Human0.47193712
152SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.46598831
153FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.46177228
154* TAF2_19829295_ChIP-Seq_ESCs_Human0.46102623
155ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.45437285
156EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.44308031
157CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.44244976
158BCAT_22108803_ChIP-Seq_LS180_Human0.43329785
159ESR1_20079471_ChIP-ChIP_T-47D_Human0.43171980
160CDX2_22108803_ChIP-Seq_LS180_Human0.42162767
161PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.42133510
162SRY_22984422_ChIP-ChIP_TESTIS_Rat0.42082076
163GATA1_19941827_ChIP-Seq_MEL_Mouse0.41937233
164GATA3_24758297_ChIP-Seq_MCF-7_Human0.40705405
165* RACK7_27058665_Chip-Seq_MCF-7_Human0.40350526
166GATA1_19941826_ChIP-Seq_K562_Human0.39729700
167SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.39601504
168CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.39003427
169* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.38694417
170NCOR_22424771_ChIP-Seq_293T_Human0.37728244
171MYC_27129775_Chip-Seq_CORNEA_Mouse0.37540098
172E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.37467486

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.14375136
2MP0005360_urolithiasis8.05095505
3MP0005085_abnormal_gallbladder_physiolo6.33905626
4MP0005365_abnormal_bile_salt5.85761980
5MP0008875_abnormal_xenobiotic_pharmacok5.16743737
6MP0003252_abnormal_bile_duct4.01755604
7MP0003806_abnormal_nucleotide_metabolis4.01520101
8MP0010329_abnormal_lipoprotein_level3.48191126
9MP0003183_abnormal_peptide_metabolism3.22457039
10MP0009840_abnormal_foam_cell3.15471830
11MP0001666_abnormal_nutrient_absorption3.04000530
12MP0005332_abnormal_amino_acid2.86261000
13MP0001835_abnormal_antigen_presentation2.84522628
14MP0005083_abnormal_biliary_tract2.82407225
15MP0003195_calcinosis2.73041088
16MP0003303_peritoneal_inflammation2.71363715
17MP0003866_abnormal_defecation2.46873418
18MP0004019_abnormal_vitamin_homeostasis2.46472357
19MP0003763_abnormal_thymus_physiology2.41380470
20MP0005671_abnormal_response_to2.40308646
21MP0005025_abnormal_response_to2.40222072
22MP0001800_abnormal_humoral_immune2.39400448
23MP0005387_immune_system_phenotype2.36239324
24MP0001790_abnormal_immune_system2.36239324
25MP0005000_abnormal_immune_tolerance2.27760874
26MP0002419_abnormal_innate_immunity2.24379106
27MP0009785_altered_susceptibility_to2.20068546
28MP0003191_abnormal_cellular_cholesterol2.17562072
29MP0000685_abnormal_immune_system2.08047477
30MP0000609_abnormal_liver_physiology2.06457436
31MP0002138_abnormal_hepatobiliary_system2.04921309
32MP0002723_abnormal_immune_serum2.03427330
33MP0002118_abnormal_lipid_homeostasis2.01737842
34MP0001819_abnormal_immune_cell1.98764617
35MP0002420_abnormal_adaptive_immunity1.98476624
36MP0002452_abnormal_antigen_presenting1.96977818
37MP0001873_stomach_inflammation1.94732767
38MP0006082_CNS_inflammation1.90491279
39MP0005319_abnormal_enzyme/_coenzyme1.80029196
40MP0003868_abnormal_feces_composition1.78922697
41MP0002148_abnormal_hypersensitivity_rea1.71207822
42MP0001533_abnormal_skeleton_physiology1.68729203
43MP0005075_abnormal_melanosome_morpholog1.68487778
44MP0001764_abnormal_homeostasis1.65928206
45MP0009333_abnormal_splenocyte_physiolog1.65371844
46MP0000490_abnormal_crypts_of1.58721273
47MP0002396_abnormal_hematopoietic_system1.56353399
48MP0005584_abnormal_enzyme/coenzyme_acti1.53659507
49MP0004947_skin_inflammation1.53067265
50MP0005451_abnormal_body_composition1.52196162
51MP0000716_abnormal_immune_system1.50834739
52MP0009697_abnormal_copulation1.47981562
53MP0009643_abnormal_urine_homeostasis1.47856818
54MP0000465_gastrointestinal_hemorrhage1.45131762
55MP0002398_abnormal_bone_marrow1.42559639
56MP0008260_abnormal_autophagy1.40466574
57MP0005310_abnormal_salivary_gland1.34557518
58MP0002405_respiratory_system_inflammati1.34546387
59MP0003172_abnormal_lysosome_physiology1.27955107
60MP0002166_altered_tumor_susceptibility1.27563164
61MP0004858_abnormal_nervous_system1.27441655
62MP0000015_abnormal_ear_pigmentation1.25927426
63MP0002722_abnormal_immune_system1.23019001
64MP0003011_delayed_dark_adaptation1.21138630
65MP0003186_abnormal_redox_activity1.18749033
66MP0003705_abnormal_hypodermis_morpholog1.14721157
67MP0002429_abnormal_blood_cell1.14486412
68MP0005636_abnormal_mineral_homeostasis1.13169023
69MP0000703_abnormal_thymus_morphology1.12171262
70MP0000689_abnormal_spleen_morphology1.11065548
71MP0003656_abnormal_erythrocyte_physiolo1.10069519
72MP0000598_abnormal_liver_morphology1.09951076
73MP0001664_abnormal_digestion1.09824522
74MP0002277_abnormal_respiratory_mucosa1.09496683
75MP0005174_abnormal_tail_pigmentation1.09395863
76MP0000477_abnormal_intestine_morphology1.05560783
77MP0005409_darkened_coat_color1.03971087
78MP0009764_decreased_sensitivity_to1.02305511
79MP0002254_reproductive_system_inflammat1.01407648
80MP0005084_abnormal_gallbladder_morpholo1.00692498
81MP0005647_abnormal_sex_gland0.97823961
82MP0004147_increased_porphyrin_level0.96848106
83MP0002998_abnormal_bone_remodeling0.96531289
84MP0000858_altered_metastatic_potential0.91228593
85MP0000678_abnormal_parathyroid_gland0.90974445
86MP0009763_increased_sensitivity_to0.90920632
87MP0003828_pulmonary_edema0.89928224
88MP0000604_amyloidosis0.89214716
89MP0009642_abnormal_blood_homeostasis0.87313575
90MP0009278_abnormal_bone_marrow0.85814626
91MP0006036_abnormal_mitochondrial_physio0.85574452
92MP0008469_abnormal_protein_level0.85476137
93MP0010352_gastrointestinal_tract_polyps0.84947331
94MP0004510_myositis0.84914716
95MP0002876_abnormal_thyroid_physiology0.83882445
96MP0008004_abnormal_stomach_pH0.81542205
97MP0003448_altered_tumor_morphology0.81299539
98MP0002006_tumorigenesis0.80292440
99MP0005408_hypopigmentation0.78387526
100MP0001756_abnormal_urination0.77892710
101MP0004381_abnormal_hair_follicle0.77793622
102MP0009765_abnormal_xenobiotic_induced0.77077912
103MP0002822_catalepsy0.76587059
104MP0005376_homeostasis/metabolism_phenot0.76206597
105MP0010368_abnormal_lymphatic_system0.75847658
106MP0004264_abnormal_extraembryonic_tissu0.74650166
107MP0004883_abnormal_blood_vessel0.74518827
108MP0002078_abnormal_glucose_homeostasis0.73370110
109MP0005220_abnormal_exocrine_pancreas0.71657617
110MP0002971_abnormal_brown_adipose0.68165568
111MP0002136_abnormal_kidney_physiology0.66012270
112MP0004043_abnormal_pH_regulation0.64569437
113MP0005670_abnormal_white_adipose0.63971040
114MP0005266_abnormal_metabolism0.63527011
115MP0005334_abnormal_fat_pad0.63124009
116MP0005448_abnormal_energy_balance0.62373081
117MP0006035_abnormal_mitochondrial_morpho0.61461260
118MP0005535_abnormal_body_temperature0.61076521
119MP0009053_abnormal_anal_canal0.61062421
120MP0008872_abnormal_physiological_respon0.59280039
121MP0010234_abnormal_vibrissa_follicle0.55726250
122MP0002928_abnormal_bile_duct0.53729897
123MP0003300_gastrointestinal_ulcer0.53574473
124MP0003718_maternal_effect0.53267035
125MP0001661_extended_life_span0.52951529
126MP0009379_abnormal_foot_pigmentation0.50604840
127MP0004130_abnormal_muscle_cell0.50025539
128MP0003638_abnormal_response/metabolism_0.49631886
129MP0001765_abnormal_ion_homeostasis0.48970127
130MP0005395_other_phenotype0.47221697
131MP0002796_impaired_skin_barrier0.47181044
132MP0003690_abnormal_glial_cell0.47000850
133MP0004782_abnormal_surfactant_physiolog0.46991186
134MP0005166_decreased_susceptibility_to0.46639290
135MP0003329_amyloid_beta_deposits0.45841408
136MP0003724_increased_susceptibility_to0.45088222
137MP0008873_increased_physiological_sensi0.42926258
138MP0005464_abnormal_platelet_physiology0.42571137
139MP0000639_abnormal_adrenal_gland0.42562384
140MP0003953_abnormal_hormone_level0.42556452
141MP0001663_abnormal_digestive_system0.40318182
142MP0000538_abnormal_urinary_bladder0.39996736
143MP0000230_abnormal_systemic_arterial0.39096798
144MP0009384_cardiac_valve_regurgitation0.38580984
145MP0008874_decreased_physiological_sensi0.38470613
146MP0002132_abnormal_respiratory_system0.38347792
147MP0003436_decreased_susceptibility_to0.36475546
148MP0005666_abnormal_adipose_tissue0.36300239
149MP0000462_abnormal_digestive_system0.36096030
150MP0000579_abnormal_nail_morphology0.34841398
151MP0005381_digestive/alimentary_phenotyp0.34511018
152MP0010155_abnormal_intestine_physiology0.33781682
153MP0005248_abnormal_Harderian_gland0.32857261
154MP0001845_abnormal_inflammatory_respons0.31681470
155MP0009115_abnormal_fat_cell0.31477710
156MP0003075_altered_response_to0.31477140
157MP0005167_abnormal_blood-brain_barrier0.29456967
158MP0000249_abnormal_blood_vessel0.27489256
159MP0001881_abnormal_mammary_gland0.26737263

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.11466005
2Intrahepatic cholestasis (HP:0001406)7.06491259
3Deep venous thrombosis (HP:0002625)6.64115134
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.44734748
5Hypobetalipoproteinemia (HP:0003563)6.33256181
6Eczematoid dermatitis (HP:0000976)6.25309446
7Xanthomatosis (HP:0000991)5.95964177
8Prolonged partial thromboplastin time (HP:0003645)5.95846563
9Hyperlipoproteinemia (HP:0010980)4.90778272
10Abnormality of glutamine family amino acid metabolism (HP:0010902)4.74433896
11Complement deficiency (HP:0004431)4.73388208
12Hyperammonemia (HP:0001987)4.65732756
13Hypolipoproteinemia (HP:0010981)4.59205810
14Elevated erythrocyte sedimentation rate (HP:0003565)4.58561780
15Hyperglycinemia (HP:0002154)4.43293829
16Myositis (HP:0100614)4.37968390
17Hyperglycinuria (HP:0003108)4.32684699
18Joint hemorrhage (HP:0005261)4.31012709
19Ketosis (HP:0001946)4.28619798
20IgM deficiency (HP:0002850)4.27073923
21Epidermoid cyst (HP:0200040)4.25875493
22Orchitis (HP:0100796)4.24127182
23Fat malabsorption (HP:0002630)4.19436458
24Abnormality of sulfur amino acid metabolism (HP:0004339)4.18883606
25Abnormality of serine family amino acid metabolism (HP:0010894)4.17247901
26Abnormality of glycine metabolism (HP:0010895)4.17247901
27Abnormality of aspartate family amino acid metabolism (HP:0010899)4.13629113
28Chronic diarrhea (HP:0002028)4.12537007
29Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.11865443
30Conjugated hyperbilirubinemia (HP:0002908)4.07672368
31Abnormality of the common coagulation pathway (HP:0010990)4.04455256
32Recurrent abscess formation (HP:0002722)4.03340792
33Abnormality of B cell number (HP:0010975)4.02932221
34Stomatitis (HP:0010280)3.99548032
35Recurrent bacterial skin infections (HP:0005406)3.99468240
36Hypoglycemic coma (HP:0001325)3.84629744
37Abnormality of methionine metabolism (HP:0010901)3.84534024
38Abnormality of macrophages (HP:0004311)3.83506528
39Hypoalphalipoproteinemia (HP:0003233)3.81963203
40Abnormal delayed hypersensitivity skin test (HP:0002963)3.79754871
41Mediastinal lymphadenopathy (HP:0100721)3.78708980
42Increased IgE level (HP:0003212)3.70567350
43B lymphocytopenia (HP:0010976)3.67938886
44Abnormality of pyrimidine metabolism (HP:0004353)3.66541439
45Optic neuritis (HP:0100653)3.63559148
46Retrobulbar optic neuritis (HP:0100654)3.63559148
47Widely patent fontanelles and sutures (HP:0004492)3.59567946
48Gastrointestinal infarctions (HP:0005244)3.51873027
49Recurrent fungal infections (HP:0002841)3.50195684
50Hypercholesterolemia (HP:0003124)3.46079656
51Abnormality of fatty-acid metabolism (HP:0004359)3.45156078
52Abnormality of complement system (HP:0005339)3.44928433
53Gingivitis (HP:0000230)3.43654336
54Abnormality of the intrinsic pathway (HP:0010989)3.42997825
55Vasculitis (HP:0002633)3.39943740
56Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.32518539
57Pustule (HP:0200039)3.30563801
58Hyperbilirubinemia (HP:0002904)3.30412093
59Thin bony cortex (HP:0002753)3.27707975
60Abnormality of nucleobase metabolism (HP:0010932)3.26440709
61Ketoacidosis (HP:0001993)3.20701288
62Encephalitis (HP:0002383)3.17903795
63Abnormality of T cell physiology (HP:0011840)3.17880075
64Meningitis (HP:0001287)3.09106058
65Gastrointestinal stroma tumor (HP:0100723)3.06593940
66Abnormality of purine metabolism (HP:0004352)3.06390344
67Delayed CNS myelination (HP:0002188)3.04548330
68Obstructive lung disease (HP:0006536)2.99846776
69Chronic obstructive pulmonary disease (HP:0006510)2.99846776
70Metabolic acidosis (HP:0001942)2.99267340
71Abnormality of serum amino acid levels (HP:0003112)2.95644481
72Inflammation of the large intestine (HP:0002037)2.95616201
73Malnutrition (HP:0004395)2.94140610
74Steatorrhea (HP:0002570)2.93079325
75Abnormality of T cells (HP:0002843)2.91209968
76Gout (HP:0001997)2.90538989
77Hepatocellular carcinoma (HP:0001402)2.90277207
78Acanthocytosis (HP:0001927)2.83862380
79Gastrointestinal inflammation (HP:0004386)2.83707304
80Spontaneous abortion (HP:0005268)2.82503187
81Recurrent bronchitis (HP:0002837)2.81580755
82Vascular calcification (HP:0004934)2.78873904
83Abnormality of dicarboxylic acid metabolism (HP:0010995)2.78836568
84Dicarboxylic aciduria (HP:0003215)2.78836568
85Myocardial infarction (HP:0001658)2.76948278
86Lethargy (HP:0001254)2.73184830
87Spontaneous hematomas (HP:0007420)2.71517954
88Lymphopenia (HP:0001888)2.69796498
89Recurrent skin infections (HP:0001581)2.69596861
90Keratoconjunctivitis sicca (HP:0001097)2.65309904
91Abnormality of the peritoneum (HP:0002585)2.63441139
92Hypochromic microcytic anemia (HP:0004840)2.62594875
93Urticaria (HP:0001025)2.61856467
94Abnormality of cells of the lymphoid lineage (HP:0012140)2.59730781
95Skin nodule (HP:0200036)2.56119380
96Pulmonary infiltrates (HP:0002113)2.55745702
97Abnormality of T cell number (HP:0011839)2.54093747
98Systemic lupus erythematosus (HP:0002725)2.52728237
99Chest pain (HP:0100749)2.50893813
100Keratoconjunctivitis (HP:0001096)2.50480621
101Hypochromic anemia (HP:0001931)2.49933550
102Cellulitis (HP:0100658)2.48255356
103Cardiovascular calcification (HP:0011915)2.45936344
104Recurrent sinusitis (HP:0011108)2.44998620
105Autoimmune thrombocytopenia (HP:0001973)2.44134051
106Hypoglycemic seizures (HP:0002173)2.43266903
107Segmental peripheral demyelination/remyelination (HP:0003481)2.41726695
108Leukocytosis (HP:0001974)2.41569850
109Cerebral edema (HP:0002181)2.41549368
110Hemoptysis (HP:0002105)2.41037919
111Granulocytopenia (HP:0001913)2.40771097
112Chronic mucocutaneous candidiasis (HP:0002728)2.39909750
113Recurrent cutaneous fungal infections (HP:0011370)2.39909750
114T lymphocytopenia (HP:0005403)2.36740780
115Hydroxyprolinuria (HP:0003080)2.36717970
116Abnormality of proline metabolism (HP:0010907)2.36717970
117Recurrent pneumonia (HP:0006532)2.35941719
118Irritability (HP:0000737)2.35231556
119Prolonged bleeding time (HP:0003010)2.34718391
120Late onset (HP:0003584)2.34239633
121Spastic diplegia (HP:0001264)2.33897703
122Abnormality of the costochondral junction (HP:0000919)2.33119521
123Generalized aminoaciduria (HP:0002909)2.32774431
124Posterior subcapsular cataract (HP:0007787)2.32301176
125Abnormal gallbladder morphology (HP:0012437)2.31810489
126Wide cranial sutures (HP:0010537)2.29369411
127Cholelithiasis (HP:0001081)2.27292133
128IgG deficiency (HP:0004315)2.26406079
129Alkalosis (HP:0001948)2.25828712
130Glycosuria (HP:0003076)2.25066829
131Abnormality of urine glucose concentration (HP:0011016)2.25066829
132Proximal tubulopathy (HP:0000114)2.24695203
133Vomiting (HP:0002013)2.23810173
134Abnormality of the vitamin B12 metabolism (HP:0004341)2.23182570
135Ileus (HP:0002595)2.22883559
136Glomerulonephritis (HP:0000099)2.22812715
137Neonatal onset (HP:0003623)2.21705203
138Sensorimotor neuropathy (HP:0007141)2.21205087
139Pancreatitis (HP:0001733)2.21176904
140Increased IgM level (HP:0003496)2.20671396
141Emphysema (HP:0002097)2.19768910
142Cholecystitis (HP:0001082)2.19669151
143Abnormal gallbladder physiology (HP:0012438)2.19669151
144Petechiae (HP:0000967)2.19491771
145Peritonitis (HP:0002586)2.18205558
146Pigmentary retinal degeneration (HP:0001146)2.18054872
147Eosinophilia (HP:0001880)2.17948840
148Rickets (HP:0002748)2.17268738
149Poikilocytosis (HP:0004447)2.15990214
150Mitral stenosis (HP:0001718)2.15314105
151Esophageal varix (HP:0002040)2.15014799
152Enlarged kidneys (HP:0000105)2.14883461
153Recurrent viral infections (HP:0004429)2.14596434
154Skin rash (HP:0000988)2.13592587
155Amyloidosis (HP:0011034)2.10784189
156Osteomyelitis (HP:0002754)2.10056721
157Enlarged epiphyses (HP:0010580)2.09486873
158Hypophosphatemia (HP:0002148)2.09300095
159Autoimmune hemolytic anemia (HP:0001890)2.08648413
160IgA deficiency (HP:0002720)2.08622986
161Increased purine levels (HP:0004368)2.07683774
162Hyperuricemia (HP:0002149)2.07683774
163Brushfield spots (HP:0001088)2.06536504
164Anorexia (HP:0002039)2.05719552
165Restrictive lung disease (HP:0002091)2.04398203
166Abnormality of vitamin B metabolism (HP:0004340)2.04029684
167Menorrhagia (HP:0000132)2.03670332
168Hypergammaglobulinemia (HP:0010702)2.03346165
169Gingival bleeding (HP:0000225)2.02961735
170Episodic fever (HP:0001954)2.02959285
171Panhypogammaglobulinemia (HP:0003139)2.01253144
172Opisthotonus (HP:0002179)2.00200904
173Premature loss of primary teeth (HP:0006323)1.99076115
174Abnormal cartilage morphology (HP:0002763)1.96851663
175Abnormality of vitamin metabolism (HP:0100508)1.95790077
176Hyperinsulinemic hypoglycemia (HP:0000825)1.95550525
177Abnormality of the pleura (HP:0002103)1.95466340
178Colitis (HP:0002583)1.95064195
179Recurrent gram-negative bacterial infections (HP:0005420)1.94986460
180Hemorrhage of the eye (HP:0011885)1.94624812
181Abnormality of the gallbladder (HP:0005264)1.94299899
182Hypophosphatemic rickets (HP:0004912)1.93705026
183Abnormal enzyme/coenzyme activity (HP:0012379)1.92614297
184Pulmonary embolism (HP:0002204)1.91608546
185Thrombophlebitis (HP:0004418)1.90490647
186Symptomatic seizures (HP:0011145)1.87927919

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.48272669
2FGFR44.25407683
3ERN14.24634329
4SIK13.89937046
5RIPK43.53136985
6MAP4K13.45598122
7TAOK33.25633233
8MST1R3.24527639
9FRK2.86522796
10INSRR2.75160414
11ERBB42.66407154
12ACVR1B2.60329912
13IRAK42.58928526
14NLK2.21947368
15PRPF4B2.09063411
16MAP3K132.05609623
17KSR22.04708823
18MAPK111.94578242
19BLK1.88604301
20PKN21.86603036
21MAP2K41.81983958
22ZAP701.79636254
23JAK31.79188359
24PTK61.78033492
25PIK3CG1.74935403
26LMTK21.71889606
27TAOK11.68273433
28BTK1.66858956
29TNK21.66589212
30LATS11.65257701
31TXK1.61671605
32TYK21.59951140
33GRK61.57405307
34HCK1.52774572
35IRAK11.52755905
36SYK1.50791317
37FLT31.43829898
38FES1.41952543
39STK38L1.40110127
40MAP3K71.39467688
41ITK1.38736857
42DAPK21.35411743
43MAP2K61.31234946
44ABL21.30874258
45ERBB21.30709586
46NUAK11.28421185
47TRIB31.28345229
48PRKAA21.28121768
49SIK31.24836030
50NEK91.23471637
51TESK21.18051280
52MAP3K101.16756039
53LCK1.15530872
54IRAK31.13524474
55MAP3K111.08891639
56TBK11.07308959
57MET1.06755680
58JAK21.06688948
59WNK41.06009190
60KDR1.03083287
61LYN1.03064294
62MAPK151.01877670
63MAP2K20.98891965
64PRKG20.98208567
65RIPK10.96324930
66TEC0.89612310
67MAP3K140.88536577
68FGFR20.87376157
69PBK0.86637550
70JAK10.85814746
71SMG10.85735650
72MATK0.85700493
73PRKCZ0.84924470
74MAPK40.84600374
75FGR0.82852395
76MAP3K30.81103486
77YES10.78639397
78PRKD20.76907064
79MAP2K30.76388711
80PRKAA10.76290453
81EPHB10.76042787
82DYRK1B0.73688356
83PRKACG0.73556771
84CDC42BPA0.72540680
85PTK20.71693376
86OXSR10.71353263
87PINK10.71071320
88PIK3CA0.70784794
89KIT0.70079520
90KSR10.70030080
91CAMK2G0.69031522
92IRAK20.68499021
93CSK0.67705139
94GSK3A0.67655323
95FYN0.64972375
96CDK60.63430375
97MARK20.63146364
98WNK30.61501618
99RET0.58292374
100ARAF0.58118409
101GRK10.57767489
102EPHB20.57684872
103IKBKE0.56645225
104SGK30.56176834
105PDPK10.56047464
106TIE10.55533844
107RAF10.54664716
108IKBKB0.54166493
109PIM10.52925638
110MARK30.52832565
111PRKCI0.52143457
112SIK20.52129060
113HIPK20.51947447
114PRKCQ0.47985897
115MAP2K10.47043050
116MAPK120.46108278
117PDK30.45984292
118PDK40.45984292
119MYLK0.44766017
120BMPR20.44257557
121MAP3K10.43933762
122CDK190.43812582
123MAP3K20.42839224
124AKT30.42632940
125MAP3K90.40221940
126CAMKK10.39282310
127CAMK1D0.36146416
128CDK40.35883537
129EPHA30.35181733
130PTK2B0.35109088
131PRKCA0.35026357
132TGFBR20.34832520
133SGK20.34807831
134STK110.33678364
135CSNK1G10.32365920
136PDK10.31622150
137MAP3K80.31104627
138SGK4940.31078235
139SGK2230.31078235
140MAP3K60.30484783
141IGF1R0.30395812
142FGFR30.28387047
143EPHA20.28335137
144MAPK70.28164280
145STK390.24157692
146BMX0.22635356
147CSF1R0.22557079
148ICK0.21436654
149EPHA40.21323753
150TAOK20.21231854
151MTOR0.21149217
152NME10.19224933
153CAMK40.18978906

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.15519582
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.51396844
3Nitrogen metabolism_Homo sapiens_hsa009103.42545397
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.04914472
5Arginine biosynthesis_Homo sapiens_hsa002202.91330428
6Tryptophan metabolism_Homo sapiens_hsa003802.76845072
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.64555520
8Primary immunodeficiency_Homo sapiens_hsa053402.61112620
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.54057890
10Fatty acid degradation_Homo sapiens_hsa000712.52546589
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.43412430
12Complement and coagulation cascades_Homo sapiens_hsa046102.42611223
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.41971598
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.41336195
15Butanoate metabolism_Homo sapiens_hsa006502.26487908
16Allograft rejection_Homo sapiens_hsa053302.23628252
17Leishmaniasis_Homo sapiens_hsa051402.16810213
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.12647773
19Autoimmune thyroid disease_Homo sapiens_hsa053202.10995214
20Graft-versus-host disease_Homo sapiens_hsa053322.09275504
21Peroxisome_Homo sapiens_hsa041462.07236141
22Histidine metabolism_Homo sapiens_hsa003402.03614549
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.99378247
24Osteoclast differentiation_Homo sapiens_hsa043801.94533516
25Propanoate metabolism_Homo sapiens_hsa006401.93261238
26Chemical carcinogenesis_Homo sapiens_hsa052041.89573626
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.87725696
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.87225929
29PPAR signaling pathway_Homo sapiens_hsa033201.84802850
30Caffeine metabolism_Homo sapiens_hsa002321.79075774
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.77360586
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.76333473
33Fatty acid metabolism_Homo sapiens_hsa012121.74763328
34beta-Alanine metabolism_Homo sapiens_hsa004101.72994975
35Retinol metabolism_Homo sapiens_hsa008301.69132823
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.65708943
37Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.65364720
38Bile secretion_Homo sapiens_hsa049761.63713525
39Sulfur metabolism_Homo sapiens_hsa009201.63152457
40T cell receptor signaling pathway_Homo sapiens_hsa046601.62999719
41B cell receptor signaling pathway_Homo sapiens_hsa046621.59226793
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.58315159
43Selenocompound metabolism_Homo sapiens_hsa004501.56874274
44Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.56763615
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.55732443
46Staphylococcus aureus infection_Homo sapiens_hsa051501.52380160
47Type I diabetes mellitus_Homo sapiens_hsa049401.50034551
48Fat digestion and absorption_Homo sapiens_hsa049751.49653235
49Pyruvate metabolism_Homo sapiens_hsa006201.47497936
50Asthma_Homo sapiens_hsa053101.45524928
51Tuberculosis_Homo sapiens_hsa051521.45306144
52Phenylalanine metabolism_Homo sapiens_hsa003601.44122680
53Starch and sucrose metabolism_Homo sapiens_hsa005001.42227537
54Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.37156532
55Folate biosynthesis_Homo sapiens_hsa007901.37100702
56NF-kappa B signaling pathway_Homo sapiens_hsa040641.36511870
57Hematopoietic cell lineage_Homo sapiens_hsa046401.35439321
58Tyrosine metabolism_Homo sapiens_hsa003501.33435580
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30614701
60Chemokine signaling pathway_Homo sapiens_hsa040621.26716618
61Maturity onset diabetes of the young_Homo sapiens_hsa049501.25965429
62Cyanoamino acid metabolism_Homo sapiens_hsa004601.25524583
63Antigen processing and presentation_Homo sapiens_hsa046121.24581683
64ABC transporters_Homo sapiens_hsa020101.21724352
65Fatty acid elongation_Homo sapiens_hsa000621.21313484
66Acute myeloid leukemia_Homo sapiens_hsa052211.20995582
67Cysteine and methionine metabolism_Homo sapiens_hsa002701.20606935
68Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.20447758
69Carbon metabolism_Homo sapiens_hsa012001.19123740
70Toll-like receptor signaling pathway_Homo sapiens_hsa046201.17487133
71Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.16055077
72Biosynthesis of amino acids_Homo sapiens_hsa012301.14121760
73Vitamin digestion and absorption_Homo sapiens_hsa049771.13796986
74Steroid biosynthesis_Homo sapiens_hsa001001.13345024
75Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.11456276
76Toxoplasmosis_Homo sapiens_hsa051451.11430728
77Viral myocarditis_Homo sapiens_hsa054161.09615325
78Arginine and proline metabolism_Homo sapiens_hsa003301.07560935
79Measles_Homo sapiens_hsa051621.06244442
80Influenza A_Homo sapiens_hsa051641.04202707
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02813617
82NOD-like receptor signaling pathway_Homo sapiens_hsa046210.98159429
83Sulfur relay system_Homo sapiens_hsa041220.97071583
84TNF signaling pathway_Homo sapiens_hsa046680.96647201
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.96191520
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.92244657
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.90460040
88Jak-STAT signaling pathway_Homo sapiens_hsa046300.89798683
89Herpes simplex infection_Homo sapiens_hsa051680.88380320
90Lysine degradation_Homo sapiens_hsa003100.85081733
91Vitamin B6 metabolism_Homo sapiens_hsa007500.81711147
92Pertussis_Homo sapiens_hsa051330.81417264
93Glutathione metabolism_Homo sapiens_hsa004800.80173578
94RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.79490740
95Hepatitis B_Homo sapiens_hsa051610.79151963
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78568178
97Glycerolipid metabolism_Homo sapiens_hsa005610.77926902
98Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.77617050
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74157674
100Other glycan degradation_Homo sapiens_hsa005110.71909355
101One carbon pool by folate_Homo sapiens_hsa006700.70481941
102Malaria_Homo sapiens_hsa051440.70106871
103Ether lipid metabolism_Homo sapiens_hsa005650.69365022
104Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.64932452
105Pentose phosphate pathway_Homo sapiens_hsa000300.64115549
106Non-small cell lung cancer_Homo sapiens_hsa052230.60902509
107Prolactin signaling pathway_Homo sapiens_hsa049170.58552168
108Phagosome_Homo sapiens_hsa041450.58518405
109VEGF signaling pathway_Homo sapiens_hsa043700.55598081
110Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54541658
111Apoptosis_Homo sapiens_hsa042100.52436698
112FoxO signaling pathway_Homo sapiens_hsa040680.52285541
113Metabolic pathways_Homo sapiens_hsa011000.50578954
114GnRH signaling pathway_Homo sapiens_hsa049120.49868158
115Platelet activation_Homo sapiens_hsa046110.49307991
116Galactose metabolism_Homo sapiens_hsa000520.48866912
117Fructose and mannose metabolism_Homo sapiens_hsa000510.48186977
118Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47342916
119Legionellosis_Homo sapiens_hsa051340.46640649
120Choline metabolism in cancer_Homo sapiens_hsa052310.45891922
121Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44779626
122Pancreatic cancer_Homo sapiens_hsa052120.43972254
123Salmonella infection_Homo sapiens_hsa051320.43629134
124AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.43346786
125Fatty acid biosynthesis_Homo sapiens_hsa000610.39984450
126Sphingolipid signaling pathway_Homo sapiens_hsa040710.35813366
127Chronic myeloid leukemia_Homo sapiens_hsa052200.35800018
128Dorso-ventral axis formation_Homo sapiens_hsa043200.35136226
129Neurotrophin signaling pathway_Homo sapiens_hsa047220.34695490
130Phospholipase D signaling pathway_Homo sapiens_hsa040720.34644083
131Endocytosis_Homo sapiens_hsa041440.33743778
132Pancreatic secretion_Homo sapiens_hsa049720.33607992
133Shigellosis_Homo sapiens_hsa051310.33278301
134Rheumatoid arthritis_Homo sapiens_hsa053230.32478404
135alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32166625
136Linoleic acid metabolism_Homo sapiens_hsa005910.23428442
137Insulin resistance_Homo sapiens_hsa049310.19837010
138Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.17948186
139Glycerophospholipid metabolism_Homo sapiens_hsa005640.17899917
140Prion diseases_Homo sapiens_hsa050200.17324006
141Renin-angiotensin system_Homo sapiens_hsa046140.15563584
142Adipocytokine signaling pathway_Homo sapiens_hsa049200.14044346
143Mineral absorption_Homo sapiens_hsa049780.11791495
144Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.08708175
145Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.08437527
146Glucagon signaling pathway_Homo sapiens_hsa049220.03420257
147Carbohydrate digestion and absorption_Homo sapiens_hsa049730.02328039
148Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.2338232
149Regulation of autophagy_Homo sapiens_hsa04140-0.2316398
150Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.2298175
151Oxidative phosphorylation_Homo sapiens_hsa00190-0.2278150
152Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.2122017
153Systemic lupus erythematosus_Homo sapiens_hsa05322-0.2062421
154Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1877363
155Bladder cancer_Homo sapiens_hsa05219-0.1812507
156Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1647426
157African trypanosomiasis_Homo sapiens_hsa05143-0.1533793
158Insulin signaling pathway_Homo sapiens_hsa04910-0.1461167
159Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1199227
160Hepatitis C_Homo sapiens_hsa05160-0.1158263
161Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1144270
162Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0638924
163Protein digestion and absorption_Homo sapiens_hsa04974-0.0265556
164AMPK signaling pathway_Homo sapiens_hsa04152-0.0093541

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