NLRP14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the NALP protein family. Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). This protein may play a regulatory role in the innate immune system as similar family members belong to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)9.91565254
2multicellular organism reproduction (GO:0032504)9.66241244
3regulation of hypersensitivity (GO:0002883)7.59421341
4reproduction (GO:0000003)7.46656717
5protein K11-linked deubiquitination (GO:0035871)7.27512165
6DNA methylation involved in gamete generation (GO:0043046)7.25461038
7presynaptic membrane assembly (GO:0097105)6.77313124
8female gamete generation (GO:0007292)6.29423912
9cAMP catabolic process (GO:0006198)6.20603664
10citrulline biosynthetic process (GO:0019240)6.09791526
11positive regulation of humoral immune response (GO:0002922)5.98906211
12binding of sperm to zona pellucida (GO:0007339)5.98343246
13L-amino acid import (GO:0043092)5.97512161
14mitotic chromosome condensation (GO:0007076)5.88052004
15negative regulation of reproductive process (GO:2000242)5.80198580
16positive regulation of inflammatory response to antigenic stimulus (GO:0002863)5.78360624
17C4-dicarboxylate transport (GO:0015740)5.71638831
18protein localization to kinetochore (GO:0034501)5.67392866
19nonmotile primary cilium assembly (GO:0035058)5.66112518
20mitotic metaphase plate congression (GO:0007080)5.59178090
21regulation of meiosis (GO:0040020)5.50591248
22cyclic nucleotide catabolic process (GO:0009214)5.50242928
23male meiosis (GO:0007140)5.48712332
24regulation of phospholipid biosynthetic process (GO:0071071)5.46989400
25single fertilization (GO:0007338)5.42371912
26fertilization (GO:0009566)5.42180876
27regulation of exit from mitosis (GO:0007096)5.40877261
28presynaptic membrane organization (GO:0097090)5.40139679
29meiotic cell cycle (GO:0051321)5.34899728
30oocyte development (GO:0048599)5.33664230
31auditory behavior (GO:0031223)5.31306613
32protein localization to chromosome, centromeric region (GO:0071459)5.17016118
33negative regulation of translation, ncRNA-mediated (GO:0040033)5.14037639
34regulation of translation, ncRNA-mediated (GO:0045974)5.14037639
35negative regulation of translation involved in gene silencing by miRNA (GO:0035278)5.14037639
36righting reflex (GO:0060013)5.12456028
37regulation of acute inflammatory response to antigenic stimulus (GO:0002864)5.07006111
38protein kinase C signaling (GO:0070528)5.04713749
39sperm-egg recognition (GO:0035036)5.02077426
40negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.95383985
41mitotic sister chromatid segregation (GO:0000070)4.85386283
42amino acid import (GO:0043090)4.75827428
43metaphase plate congression (GO:0051310)4.73830937
44immunoglobulin mediated immune response (GO:0016064)4.68479170
45regulation of meiosis I (GO:0060631)4.64835499
46oocyte maturation (GO:0001556)4.61603433
47translesion synthesis (GO:0019985)4.61601970
48epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.60033126
49negative regulation of meiosis (GO:0045835)4.56935167
50DNA alkylation (GO:0006305)4.51103821
51DNA methylation (GO:0006306)4.51103821
52negative regulation of synaptic transmission, GABAergic (GO:0032229)4.44790405
53establishment of chromosome localization (GO:0051303)4.40127850
54microtubule severing (GO:0051013)4.38726244
55cell-cell recognition (GO:0009988)4.38679666
56regulation of meiotic cell cycle (GO:0051445)4.33117287
57regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.30687042
58positive regulation of megakaryocyte differentiation (GO:0045654)4.26445820
59mechanosensory behavior (GO:0007638)4.23858873
60gene silencing by RNA (GO:0031047)4.21115917
61protein localization to chromosome (GO:0034502)4.15772201
62auditory receptor cell stereocilium organization (GO:0060088)4.13470618
63oogenesis (GO:0048477)4.12139617
64histone H2A monoubiquitination (GO:0035518)4.11708383
65postsynaptic membrane organization (GO:0001941)4.07151300
66centriole replication (GO:0007099)4.06973570
67regulation of sister chromatid cohesion (GO:0007063)4.04985210
68response to auditory stimulus (GO:0010996)4.04069511
69positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.01472108
70attachment of spindle microtubules to kinetochore (GO:0008608)4.00944319
71synapsis (GO:0007129)4.00483174
72cell morphogenesis involved in neuron differentiation (GO:0048667)3.99422892
73sister chromatid segregation (GO:0000819)3.95831104
74neuron fate determination (GO:0048664)3.95387172
75startle response (GO:0001964)3.94954929
76histone H2A ubiquitination (GO:0033522)3.94689402
77synaptonemal complex assembly (GO:0007130)3.93342509
78retinal cone cell development (GO:0046549)3.89450023
79regulation of retinoic acid receptor signaling pathway (GO:0048385)3.86023612
80positive regulation of chromosome segregation (GO:0051984)3.85667620
81establishment of nucleus localization (GO:0040023)3.84477115
82postreplication repair (GO:0006301)3.83358974
83glycerophospholipid catabolic process (GO:0046475)3.82228678
84protein K6-linked ubiquitination (GO:0085020)3.75660260
85detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.74598216
86regulation of histone H3-K9 methylation (GO:0051570)3.74544464
87negative regulation of histone methylation (GO:0031061)3.74158309
88positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.74118706
89brain morphogenesis (GO:0048854)3.73713740
90positive regulation of mitotic sister chromatid separation (GO:1901970)3.72778145
91positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.72778145
92positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.72778145
93notochord development (GO:0030903)3.72180682
94chromosome organization involved in meiosis (GO:0070192)3.71444770
95spindle checkpoint (GO:0031577)3.70883773
96negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.69617847
97regulation of calcium ion-dependent exocytosis (GO:0017158)3.67097280
98regulation of spindle organization (GO:0090224)3.66156648
99citrulline metabolic process (GO:0000052)3.65184511
100synaptonemal complex organization (GO:0070193)3.65181002
101interkinetic nuclear migration (GO:0022027)3.64888282
102male meiosis I (GO:0007141)3.61369544
103regulation of chromosome segregation (GO:0051983)3.60579818
104positive regulation of action potential (GO:0045760)3.60549783
105negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.58566636
106negative regulation of DNA-templated transcription, elongation (GO:0032785)3.58566636
107meiotic chromosome segregation (GO:0045132)3.56053529
108tachykinin receptor signaling pathway (GO:0007217)3.54064810
109regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.51535834
110regulation of DNA methylation (GO:0044030)3.49231844
111DNA damage induced protein phosphorylation (GO:0006975)3.43919813
112regulation of reproductive process (GO:2000241)3.42321769
113histone H2A acetylation (GO:0043968)3.42235126
114negative regulation of chromosome segregation (GO:0051985)3.41789780
115regulation of mitotic spindle organization (GO:0060236)3.41073770
116nucleus localization (GO:0051647)3.40403224
117axoneme assembly (GO:0035082)3.40398146
118chromosome segregation (GO:0007059)3.40138420
119peptidyl-arginine modification (GO:0018195)3.39662376
120positive regulation of meiosis (GO:0045836)3.38248600
121negative regulation of meiotic cell cycle (GO:0051447)3.37855146
122negative regulation of mitotic sister chromatid separation (GO:2000816)3.36633156
123negative regulation of mitotic sister chromatid segregation (GO:0033048)3.36633156
124negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.36633156
125negative regulation of sister chromatid segregation (GO:0033046)3.36633156
126B cell mediated immunity (GO:0019724)3.35968963
127negative regulation of smooth muscle cell differentiation (GO:0051151)3.35917371
128response to folic acid (GO:0051593)3.35067525
129meiotic nuclear division (GO:0007126)3.34949066
130mitotic spindle checkpoint (GO:0071174)3.33690492
131membrane assembly (GO:0071709)3.32761548
132sister chromatid cohesion (GO:0007062)3.32111427
133neurotransmitter catabolic process (GO:0042135)3.31534792
134female gonad development (GO:0008585)3.30353110
135maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.29295237
136negative regulation of amino acid transport (GO:0051956)3.28286380
137mitotic spindle assembly checkpoint (GO:0007094)3.27514797
138DNA methylation or demethylation (GO:0044728)3.26929542
139regulation of mitotic metaphase/anaphase transition (GO:0030071)3.25801490
140monoubiquitinated protein deubiquitination (GO:0035520)3.25665883
141base-excision repair, AP site formation (GO:0006285)3.25209029
142DNA double-strand break processing (GO:0000729)3.24495272
143positive regulation of meiotic cell cycle (GO:0051446)3.23687144
144regulation of mitotic sister chromatid separation (GO:0010965)3.21642699
145regulation of mitotic sister chromatid segregation (GO:0033047)3.21642699
146regulation of sister chromatid segregation (GO:0033045)3.21642699
147photoreceptor cell maintenance (GO:0045494)3.20418148
148ether lipid metabolic process (GO:0046485)3.17023643
149tongue development (GO:0043586)3.09154489
150histone H3-K9 demethylation (GO:0033169)3.08831954
151epithelial cilium movement (GO:0003351)3.07565149
152nucleotide-excision repair, DNA gap filling (GO:0006297)3.02548737
153regulation of megakaryocyte differentiation (GO:0045652)3.01780678
154meiotic cell cycle process (GO:1903046)2.98871328
155gene silencing (GO:0016458)2.97552367
156centriole assembly (GO:0098534)2.89779712
157meiosis I (GO:0007127)2.89422501
158artery smooth muscle contraction (GO:0014824)2.88823699
159anterior/posterior axis specification, embryo (GO:0008595)2.87589845
160inner ear receptor stereocilium organization (GO:0060122)2.86648513
161telencephalon development (GO:0021537)2.83393323
162negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.82508290
163resolution of meiotic recombination intermediates (GO:0000712)2.81467757
164mitotic cytokinesis (GO:0000281)2.80615172
165ionotropic glutamate receptor signaling pathway (GO:0035235)2.79800280
166cilium or flagellum-dependent cell motility (GO:0001539)2.77902401
167regulation of uterine smooth muscle contraction (GO:0070472)2.77795409
168genitalia morphogenesis (GO:0035112)2.77191435
169radial glial cell differentiation (GO:0060019)2.76769884
170cilium movement (GO:0003341)2.76066275
171oligodendrocyte differentiation (GO:0048709)2.72632416
172regulation of female gonad development (GO:2000194)12.5461763
173regulation of acrosome reaction (GO:0060046)10.3973720

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.61711103
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.95913465
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.96709419
4AR_21909140_ChIP-Seq_LNCAP_Human3.79906388
5E2F7_22180533_ChIP-Seq_HELA_Human3.70561716
6GBX2_23144817_ChIP-Seq_PC3_Human3.63902936
7KAP1_22055183_ChIP-Seq_ESCs_Mouse3.51960018
8SALL1_21062744_ChIP-ChIP_HESCs_Human3.41134672
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.26811191
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.92176593
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.74775117
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.48639117
13GATA1_26923725_Chip-Seq_HPCs_Mouse2.21656972
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.19378673
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.12060147
16SMAD_19615063_ChIP-ChIP_OVARY_Human2.03759286
17CTBP1_25329375_ChIP-Seq_LNCAP_Human2.03566417
18UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.96393565
19CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.96348233
20MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.88680907
21FLI1_27457419_Chip-Seq_LIVER_Mouse1.86646485
22VDR_22108803_ChIP-Seq_LS180_Human1.86260413
23BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.84162100
24TOP2B_26459242_ChIP-Seq_MCF-7_Human1.81315899
25PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.78051210
26SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.77652345
27NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.72971073
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.72729577
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.71461531
30FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.71261357
31ZNF274_21170338_ChIP-Seq_K562_Hela1.68959893
32RNF2_27304074_Chip-Seq_NSC_Mouse1.62554739
33P300_19829295_ChIP-Seq_ESCs_Human1.62333511
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.59974523
35BCAT_22108803_ChIP-Seq_LS180_Human1.54438269
36NR3C1_21868756_ChIP-Seq_MCF10A_Human1.54397909
37CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.53873938
38TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.53688464
39CDX2_22108803_ChIP-Seq_LS180_Human1.53270276
40MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.52573006
41TCF4_23295773_ChIP-Seq_U87_Human1.52299603
42IGF1R_20145208_ChIP-Seq_DFB_Human1.50560945
43AR_21572438_ChIP-Seq_LNCaP_Human1.50374830
44SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.49583818
45GATA3_21867929_ChIP-Seq_TH1_Mouse1.49439264
46MYC_18940864_ChIP-ChIP_HL60_Human1.49020745
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.48291650
48CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47835227
49TAF15_26573619_Chip-Seq_HEK293_Human1.47817399
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.47152394
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.46373497
52WT1_19549856_ChIP-ChIP_CCG9911_Human1.45528737
53AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.45380776
54PRDM14_20953172_ChIP-Seq_ESCs_Human1.44768562
55SMAD4_21799915_ChIP-Seq_A2780_Human1.43563170
56RUNX1_26923725_Chip-Seq_HPCs_Mouse1.42098570
57AR_25329375_ChIP-Seq_VCAP_Human1.41880594
58KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.40107745
59OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38016879
60TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38007449
61POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.38007449
62REST_21632747_ChIP-Seq_MESCs_Mouse1.35510144
63E2F1_21310950_ChIP-Seq_MCF-7_Human1.35322879
64STAT1_17558387_ChIP-Seq_HELA_Human1.34900525
65SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34492523
66HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.31680994
67TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29006830
68SOX9_26525672_Chip-Seq_HEART_Mouse1.28885311
69TBX3_20139965_ChIP-Seq_ESCs_Mouse1.26273028
70KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.25852652
71TBX3_20139965_ChIP-Seq_MESCs_Mouse1.25572816
72JUN_21703547_ChIP-Seq_K562_Human1.24729677
73FLI1_21867929_ChIP-Seq_TH2_Mouse1.23138593
74RUNX2_22187159_ChIP-Seq_PCA_Human1.22514467
75RXR_22108803_ChIP-Seq_LS180_Human1.22317473
76CBX2_27304074_Chip-Seq_ESCs_Mouse1.22278805
77ESET_19884257_ChIP-Seq_ESCs_Mouse1.21367527
78SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20644370
79LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17539303
80NFYA_21822215_ChIP-Seq_K562_Human1.17171270
81TP53_22573176_ChIP-Seq_HFKS_Human1.15999843
82NFE2_27457419_Chip-Seq_LIVER_Mouse1.15486217
83AUTS2_25519132_ChIP-Seq_293T-REX_Human1.14397243
84CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.14251178
85SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.14123693
86KDM2B_26808549_Chip-Seq_REH_Human1.13980932
87TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12370430
88PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12356892
89LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11997832
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11964143
91MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11942944
92GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11837603
93STAT3_23295773_ChIP-Seq_U87_Human1.11747100
94CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11725594
95FOXM1_26456572_ChIP-Seq_MCF-7_Human1.10995500
96CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.10386466
97POU3F2_20337985_ChIP-ChIP_501MEL_Human1.10231393
98FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10021784
99ELK4_26923725_Chip-Seq_MESODERM_Mouse1.09870572
100NANOG_18555785_Chip-Seq_ESCs_Mouse1.09823164
101ER_23166858_ChIP-Seq_MCF-7_Human1.08360532
102TP53_16413492_ChIP-PET_HCT116_Human1.08231944
103NANOG_21062744_ChIP-ChIP_HESCs_Human1.06557937
104STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.06306541
105CBP_21632823_ChIP-Seq_H3396_Human1.06125945
106TBL1_22424771_ChIP-Seq_293T_Human1.06113327
107POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05422855
108HTT_18923047_ChIP-ChIP_STHdh_Human1.04111251
109EZH2_27304074_Chip-Seq_ESCs_Mouse1.03645088
110PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.03545009
111FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02722178
112STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.02277754
113EZH2_27294783_Chip-Seq_NPCs_Mouse1.01971128
114EP300_21415370_ChIP-Seq_HL-1_Mouse1.01841827
115ERG_20517297_ChIP-Seq_VCAP_Human1.00823026
116RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00693116
117STAT3_18555785_Chip-Seq_ESCs_Mouse1.00336570
118CTCF_18555785_Chip-Seq_ESCs_Mouse1.00299136
119ETV1_20927104_ChIP-Seq_GIST48_Human0.99473019
120KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99246493
121EWS_26573619_Chip-Seq_HEK293_Human0.98726451
122EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.98694300
123KLF4_18555785_Chip-Seq_ESCs_Mouse0.97701990
124FUS_26573619_Chip-Seq_HEK293_Human0.97517331
125SMAD3_21741376_ChIP-Seq_ESCs_Human0.97236456
126RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.97190786
127MYCN_18555785_ChIP-Seq_MESCs_Mouse0.97186117
128TAL1_26923725_Chip-Seq_HPCs_Mouse0.97151159
129TCF4_22108803_ChIP-Seq_LS180_Human0.96931093
130SMAD4_21741376_ChIP-Seq_EPCs_Human0.96877237
131ESRRB_18555785_Chip-Seq_ESCs_Mouse0.96603165
132GF1B_26923725_Chip-Seq_HPCs_Mouse0.96341532
133PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95293028
134HNFA_21074721_ChIP-Seq_CACO-2_Human0.95141793
135MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.94281035
136NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.94166323
137NMYC_18555785_Chip-Seq_ESCs_Mouse0.92833845
138EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92521251
139NANOG_20526341_ChIP-Seq_ESCs_Human0.92098467
140YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91473595
141E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.91407503
142TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.90982652
143CBX2_22325352_ChIP-Seq_293T-Rex_Human0.89968693
144OCT4_18555785_Chip-Seq_ESCs_Mouse0.89870780
145ZFX_18555785_Chip-Seq_ESCs_Mouse0.89350104
146PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88845671
147SOX2_18555785_Chip-Seq_ESCs_Mouse0.88126599
148FOXH1_21741376_ChIP-Seq_EPCs_Human0.87834433
149GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.87548386
150ARNT_22903824_ChIP-Seq_MCF-7_Human0.87044436
151SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.86720693
152OCT4_21477851_ChIP-Seq_ESCs_Mouse0.86675252
153CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.86331533
154NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.84716982
155CTBP2_25329375_ChIP-Seq_LNCAP_Human0.84511276
156* SPI1_26923725_Chip-Seq_HPCs_Mouse0.84222244
157RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.84043992
158FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.83687854
159EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.83626308
160NFYB_21822215_ChIP-Seq_K562_Human0.83594413
161TP63_19390658_ChIP-ChIP_HaCaT_Human0.80618514
162* GATA3_26560356_Chip-Seq_TH1_Human0.80260619
163GF1_26923725_Chip-Seq_HPCs_Mouse0.80054122

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect8.05704812
2MP0008877_abnormal_DNA_methylation5.11447823
3MP0003646_muscle_fatigue4.76855224
4MP0005451_abnormal_body_composition3.86995675
5MP0010094_abnormal_chromosome_stability3.73636361
6MP0003699_abnormal_female_reproductive3.55413138
7MP0003693_abnormal_embryo_hatching3.51609021
8MP0005395_other_phenotype3.51002266
9MP0001929_abnormal_gametogenesis3.47952408
10MP0001119_abnormal_female_reproductive3.33475300
11MP0002736_abnormal_nociception_after3.14439274
12MP0002102_abnormal_ear_morphology3.12582607
13MP0000653_abnormal_sex_gland2.78713009
14MP0003077_abnormal_cell_cycle2.77169198
15MP0003121_genomic_imprinting2.63731637
16MP0003111_abnormal_nucleus_morphology2.60993275
17MP0008789_abnormal_olfactory_epithelium2.59483981
18MP0002210_abnormal_sex_determination2.59264766
19MP0000566_synostosis2.54813419
20MP0001968_abnormal_touch/_nociception2.41615161
21MP0004957_abnormal_blastocyst_morpholog2.38441052
22MP0000383_abnormal_hair_follicle2.37686194
23MP0004742_abnormal_vestibular_system2.34137882
24MP0003136_yellow_coat_color2.30032266
25MP0005394_taste/olfaction_phenotype2.29732310
26MP0005499_abnormal_olfactory_system2.29732310
27MP0003880_abnormal_central_pattern2.28719535
28MP0002161_abnormal_fertility/fecundity2.26776071
29MP0010030_abnormal_orbit_morphology2.09357878
30MP0000579_abnormal_nail_morphology2.08923589
31MP0002638_abnormal_pupillary_reflex2.08609433
32MP0001984_abnormal_olfaction2.07311663
33MP0001919_abnormal_reproductive_system2.03045369
34MP0003787_abnormal_imprinting1.99486596
35MP0002653_abnormal_ependyma_morphology1.91521852
36MP0003123_paternal_imprinting1.87030276
37MP0002295_abnormal_pulmonary_circulatio1.85466983
38MP0000631_abnormal_neuroendocrine_gland1.82776650
39MP0001145_abnormal_male_reproductive1.73916228
40MP0002249_abnormal_larynx_morphology1.63981776
41MP0005389_reproductive_system_phenotype1.62930916
42MP0000569_abnormal_digit_pigmentation1.62200398
43MP0008932_abnormal_embryonic_tissue1.61027868
44MP0001905_abnormal_dopamine_level1.59862955
45MP0003698_abnormal_male_reproductive1.54490245
46MP0006072_abnormal_retinal_apoptosis1.52756346
47MP0005551_abnormal_eye_electrophysiolog1.50742279
48MP0003890_abnormal_embryonic-extraembry1.50220306
49MP0002272_abnormal_nervous_system1.47748669
50MP0003315_abnormal_perineum_morphology1.45756785
51MP0005423_abnormal_somatic_nervous1.44137782
52MP0005408_hypopigmentation1.43217743
53MP0001486_abnormal_startle_reflex1.42643861
54MP0001730_embryonic_growth_arrest1.40638240
55MP0000026_abnormal_inner_ear1.40271984
56MP0005410_abnormal_fertilization1.39664256
57MP0001293_anophthalmia1.38889926
58MP0003635_abnormal_synaptic_transmissio1.35719200
59MP0003937_abnormal_limbs/digits/tail_de1.35389524
60MP0005646_abnormal_pituitary_gland1.34730790
61MP0004264_abnormal_extraembryonic_tissu1.28523034
62MP0003329_amyloid_beta_deposits1.27909391
63MP0006276_abnormal_autonomic_nervous1.27710325
64MP0005174_abnormal_tail_pigmentation1.25087711
65MP0001986_abnormal_taste_sensitivity1.24651211
66MP0003950_abnormal_plasma_membrane1.19992109
67MP0002234_abnormal_pharynx_morphology1.18790351
68MP0002095_abnormal_skin_pigmentation1.18607681
69MP0000350_abnormal_cell_proliferation1.18604017
70MP0006292_abnormal_olfactory_placode1.17066674
71MP0005380_embryogenesis_phenotype1.15628196
72MP0001672_abnormal_embryogenesis/_devel1.15628196
73MP0009384_cardiac_valve_regurgitation1.14214711
74MP0009379_abnormal_foot_pigmentation1.11059765
75MP0002085_abnormal_embryonic_tissue1.10401482
76MP0002735_abnormal_chemical_nociception1.10143638
77MP0000647_abnormal_sebaceous_gland1.09670580
78MP0000462_abnormal_digestive_system1.06840637
79MP0008057_abnormal_DNA_replication1.06014171
80MP0002067_abnormal_sensory_capabilities1.05147595
81MP0001529_abnormal_vocalization1.04689043
82MP0001915_intracranial_hemorrhage1.04505239
83MP0001963_abnormal_hearing_physiology1.04199808
84MP0004859_abnormal_synaptic_plasticity1.02960807
85MP0003119_abnormal_digestive_system1.02739537
86MP0002233_abnormal_nose_morphology1.02141715
87MP0002932_abnormal_joint_morphology1.01690582
88MP0008007_abnormal_cellular_replicative1.01675280
89MP0001697_abnormal_embryo_size0.96097410
90MP0005360_urolithiasis0.93849255
91MP0009697_abnormal_copulation0.93185124
92MP0001502_abnormal_circadian_rhythm0.92961671
93MP0002064_seizures0.92347159
94MP0005248_abnormal_Harderian_gland0.92099018
95MP0001879_abnormal_lymphatic_vessel0.91924573
96MP0000015_abnormal_ear_pigmentation0.91592164
97MP0002734_abnormal_mechanical_nocicepti0.91312143
98MP0002229_neurodegeneration0.90955983
99MP0002752_abnormal_somatic_nervous0.90286664
100MP0003656_abnormal_erythrocyte_physiolo0.90039091
101MP0001177_atelectasis0.89544352
102MP0002019_abnormal_tumor_incidence0.89368003
103MP0002557_abnormal_social/conspecific_i0.89307595
104MP0002084_abnormal_developmental_patter0.89099548
105MP0003786_premature_aging0.87607369
106MP0005187_abnormal_penis_morphology0.85971544
107MP0005195_abnormal_posterior_eye0.84238530
108MP0003567_abnormal_fetal_cardiomyocyte0.83904699
109MP0008875_abnormal_xenobiotic_pharmacok0.83549761
110MP0002282_abnormal_trachea_morphology0.83039545
111MP0009745_abnormal_behavioral_response0.82706833
112MP0008058_abnormal_DNA_repair0.82169285
113MP0000778_abnormal_nervous_system0.81284455
114MP0001664_abnormal_digestion0.78465593
115MP0000955_abnormal_spinal_cord0.78226238
116MP0000750_abnormal_muscle_regeneration0.78008966
117MP0002089_abnormal_postnatal_growth/wei0.77729288
118MP0002882_abnormal_neuron_morphology0.77280288
119MP0005647_abnormal_sex_gland0.77031939
120MP0002063_abnormal_learning/memory/cond0.76966092
121MP0002152_abnormal_brain_morphology0.76427199
122MP0010368_abnormal_lymphatic_system0.76372647
123MP0003935_abnormal_craniofacial_develop0.75274282
124MP0000733_abnormal_muscle_development0.72992617
125MP0000639_abnormal_adrenal_gland0.72852237
126MP0003879_abnormal_hair_cell0.71023362
127MP0009046_muscle_twitch0.70783174
128MP0005253_abnormal_eye_physiology0.70383001
129MP0003868_abnormal_feces_composition0.70186017
130MP0000678_abnormal_parathyroid_gland0.69987682
131MP0008004_abnormal_stomach_pH0.69332739
132MP0000762_abnormal_tongue_morphology0.67320647
133MP0002177_abnormal_outer_ear0.67079590
134MP0001485_abnormal_pinna_reflex0.66970485
135MP0000465_gastrointestinal_hemorrhage0.66684686
136MP0003453_abnormal_keratinocyte_physiol0.66188170
137MP0002877_abnormal_melanocyte_morpholog0.63307729
138MP0004185_abnormal_adipocyte_glucose0.60120136
139MP0005197_abnormal_uvea_morphology0.59902407
140MP0000604_amyloidosis0.58683788
141MP0003763_abnormal_thymus_physiology0.58272202
142MP0005621_abnormal_cell_physiology0.57699626
143MP0005310_abnormal_salivary_gland0.57405552
144MP0000313_abnormal_cell_death0.55949334
145MP0005023_abnormal_wound_healing0.55455951
146MP0004145_abnormal_muscle_electrophysio0.54911472
147MP0003755_abnormal_palate_morphology0.54769222
148MP0008260_abnormal_autophagy0.53471020
149MP0002080_prenatal_lethality0.51662770
150MP0000427_abnormal_hair_cycle0.51182290
151MP0003984_embryonic_growth_retardation0.50741656
152MP0010386_abnormal_urinary_bladder0.50488227
153MP0004270_analgesia0.50335183
154MP0005384_cellular_phenotype0.49986142
155MP0002269_muscular_atrophy0.49746319
156MP0003861_abnormal_nervous_system0.48353669
157MP0004510_myositis0.47640572
158MP0002088_abnormal_embryonic_growth/wei0.46732809
159MP0002160_abnormal_reproductive_system0.44656465
160MP0005257_abnormal_intraocular_pressure0.42972247
161MP0010234_abnormal_vibrissa_follicle0.41567920
162MP0004036_abnormal_muscle_relaxation0.38450944
163MP0002086_abnormal_extraembryonic_tissu0.38042237
164MP0002837_dystrophic_cardiac_calcinosis0.37757649
165MP0010678_abnormal_skin_adnexa0.37500060

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)6.34558285
2Megalencephaly (HP:0001355)6.13567836
3Premature ovarian failure (HP:0008209)6.05777345
4Male infertility (HP:0003251)6.04834107
5Infertility (HP:0000789)5.74649393
6Congenital sensorineural hearing impairment (HP:0008527)5.60240982
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.47019133
8Cortical dysplasia (HP:0002539)5.21338684
9Deep venous thrombosis (HP:0002625)4.86263865
10Chromsome breakage (HP:0040012)4.76111114
11Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)4.73549684
12Stomach cancer (HP:0012126)4.65272190
13Impulsivity (HP:0100710)4.36682436
14Chromosomal breakage induced by crosslinking agents (HP:0003221)4.33097841
15Secondary amenorrhea (HP:0000869)4.19767293
16Papillary thyroid carcinoma (HP:0002895)4.04531994
17Hypergonadotropic hypogonadism (HP:0000815)3.84726081
18Abnormality of the labia minora (HP:0012880)3.82850626
19Flat capital femoral epiphysis (HP:0003370)3.82591299
20Facial hemangioma (HP:0000329)3.72887192
21Cholecystitis (HP:0001082)3.69971145
22Abnormal gallbladder physiology (HP:0012438)3.69971145
23Abnormality of chromosome segregation (HP:0002916)3.66199177
24Chronic bronchitis (HP:0004469)3.62359515
25Pendular nystagmus (HP:0012043)3.60877296
26Birth length less than 3rd percentile (HP:0003561)3.56602002
27Osteomalacia (HP:0002749)3.53483153
28Rhabdomyosarcoma (HP:0002859)3.49638907
29Horizontal nystagmus (HP:0000666)3.45793198
30Pulmonary fibrosis (HP:0002206)3.39872912
31Hemiplegia (HP:0002301)3.35183542
32Breast hypoplasia (HP:0003187)3.29841471
33Patellar aplasia (HP:0006443)3.23957276
34Malnutrition (HP:0004395)3.19260571
35Hemiparesis (HP:0001269)3.06322934
36Adrenal hypoplasia (HP:0000835)3.05866086
37Shawl scrotum (HP:0000049)3.03447715
38Abnormal respiratory motile cilium physiology (HP:0012261)2.98759490
39Aplasia/Hypoplasia of the patella (HP:0006498)2.96227686
40Medial flaring of the eyebrow (HP:0010747)2.95158415
41Central scotoma (HP:0000603)2.93674017
42Supernumerary spleens (HP:0009799)2.92498261
43Upper motor neuron abnormality (HP:0002127)2.87935956
44Gastroesophageal reflux (HP:0002020)2.85247430
45Aplasia/Hypoplasia of the sternum (HP:0006714)2.84678249
46Abnormal ciliary motility (HP:0012262)2.83040658
47Tented upper lip vermilion (HP:0010804)2.80437749
48Abnormality of the proximal phalanges of the hand (HP:0009834)2.79766345
49Insulin-resistant diabetes mellitus (HP:0000831)2.75806005
503-Methylglutaconic aciduria (HP:0003535)2.74983513
51Arterial tortuosity (HP:0005116)2.72876686
52Acute myeloid leukemia (HP:0004808)2.71239127
53Thickened helices (HP:0000391)2.71208136
54Cupped ear (HP:0000378)2.70436557
55Carpal bone hypoplasia (HP:0001498)2.70417726
56Oligodactyly (hands) (HP:0001180)2.67452243
57Nephroblastoma (Wilms tumor) (HP:0002667)2.64699676
58Combined immunodeficiency (HP:0005387)2.64499654
59Duodenal stenosis (HP:0100867)2.64272958
60Small intestinal stenosis (HP:0012848)2.64272958
61Apathy (HP:0000741)2.60179219
62Capillary hemangiomas (HP:0005306)2.59682122
63Ectopic kidney (HP:0000086)2.56692055
64Aplasia/Hypoplasia of the tongue (HP:0010295)2.55408705
65Sandal gap (HP:0001852)2.54731620
66Absent speech (HP:0001344)2.53172010
67Abnormality of small intestinal villus morphology (HP:0011472)2.53133726
68Villous atrophy (HP:0011473)2.53133726
69Neoplasm of striated muscle (HP:0009728)2.48640291
70Abnormality of secondary sexual hair (HP:0009888)2.48358952
71Abnormality of the axillary hair (HP:0100134)2.48358952
72Abnormality of the septum pellucidum (HP:0007375)2.48334191
73Severe visual impairment (HP:0001141)2.47769849
74Abnormality of chromosome stability (HP:0003220)2.47616793
75Atelectasis (HP:0100750)2.47608811
76Embryonal renal neoplasm (HP:0011794)2.45734123
77Truncal obesity (HP:0001956)2.44239867
78Abnormal lung lobation (HP:0002101)2.44045786
79Progressive cerebellar ataxia (HP:0002073)2.43632792
80Primary amenorrhea (HP:0000786)2.42944429
81Abnormality of macular pigmentation (HP:0008002)2.42814057
82Sloping forehead (HP:0000340)2.42011860
83Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.38800175
84Short 1st metacarpal (HP:0010034)2.38800175
85Congenital primary aphakia (HP:0007707)2.37730292
86Rhinitis (HP:0012384)2.36354764
87Aplasia/Hypoplasia of the uvula (HP:0010293)2.35339801
88Gait imbalance (HP:0002141)2.34107637
89Fetal akinesia sequence (HP:0001989)2.33980542
90Vascular tortuosity (HP:0004948)2.33351856
91Diminished motivation (HP:0000745)2.33025033
92Aplasia/Hypoplasia involving the musculature (HP:0001460)2.32211723
93Wrist flexion contracture (HP:0001239)2.30981943
94Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.29750911
95Aplasia/Hypoplasia of the breasts (HP:0010311)2.27200632
96Abnormal respiratory motile cilium morphology (HP:0005938)2.17986544
97Abnormal respiratory epithelium morphology (HP:0012253)2.17986544
98Breast aplasia (HP:0100783)2.17736592
99Abnormality of the epiphysis of the femoral head (HP:0010574)2.17213226
100Amniotic constriction ring (HP:0009775)2.15323273
101Abnormality of placental membranes (HP:0011409)2.15323273
102Bronchiectasis (HP:0002110)2.14613102
103Shoulder girdle muscle weakness (HP:0003547)2.14535496
104Colon cancer (HP:0003003)2.14306575
105Abnormality of the preputium (HP:0100587)2.12617567
106Oligodactyly (HP:0012165)2.11671377
107Microglossia (HP:0000171)2.10460741
108Aplasia/Hypoplasia of the earlobes (HP:0009906)2.09607870
109True hermaphroditism (HP:0010459)2.09273709
110Abnormality of midbrain morphology (HP:0002418)2.08976301
111Molar tooth sign on MRI (HP:0002419)2.08976301
112Spondylolisthesis (HP:0003302)2.08863755
113Tetraparesis (HP:0002273)2.08696796
114Septo-optic dysplasia (HP:0100842)2.08398792
115Absent radius (HP:0003974)2.07861940
116Generalized aminoaciduria (HP:0002909)2.07818402
117Nephrogenic diabetes insipidus (HP:0009806)2.07794860
118Astigmatism (HP:0000483)2.06956972
119Abnormality of the 1st metacarpal (HP:0010009)2.06465175
120Hypoplasia of the capital femoral epiphysis (HP:0003090)2.06164886
121Anterior segment dysgenesis (HP:0007700)2.05327669
122Abnormality of the fovea (HP:0000493)2.05245275
123Lip pit (HP:0100267)2.04615469
124Meckel diverticulum (HP:0002245)2.04614045
125Pancreatic fibrosis (HP:0100732)2.03070446
126Pancreatic cysts (HP:0001737)2.02689109
127Chronic hepatic failure (HP:0100626)1.99842983
128Aplasia involving forearm bones (HP:0009822)1.99359279
129Absent forearm bone (HP:0003953)1.99359279
130Nephronophthisis (HP:0000090)1.98810111
131Abnormality of the femoral head (HP:0003368)1.97521838
132Abnormality of the duodenum (HP:0002246)1.97497401
133Hypoplasia of the fovea (HP:0007750)1.96447094
134Aplasia/Hypoplasia of the fovea (HP:0008060)1.96447094
135Widely spaced teeth (HP:0000687)1.95745757
136Abnormality of femoral epiphyses (HP:0006499)1.95315968
137Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.95315968
138Subacute progressive viral hepatitis (HP:0006572)1.94759583
139Long clavicles (HP:0000890)1.94406086
140Short thumb (HP:0009778)1.94181895
141Thyroid carcinoma (HP:0002890)1.93189891
142Genital tract atresia (HP:0001827)1.92391610
143Myelodysplasia (HP:0002863)1.91962495
144Large earlobe (HP:0009748)1.91542129
145Absence seizures (HP:0002121)1.91493488
146Occipital encephalocele (HP:0002085)1.90736350
147Abnormality of cochlea (HP:0000375)1.90636851
148Dynein arm defect of respiratory motile cilia (HP:0012255)1.90545966
149Absent/shortened dynein arms (HP:0200106)1.90545966
150Tubulointerstitial fibrosis (HP:0005576)1.90432383
151Abnormal sex determination (HP:0012244)1.90406207
152Sex reversal (HP:0012245)1.90406207
153Irregular epiphyses (HP:0010582)1.90285704
154Abnormality of the ileum (HP:0001549)1.88086276
155Rib fusion (HP:0000902)1.87765411
156Postaxial hand polydactyly (HP:0001162)1.86672127
157Leiomyosarcoma (HP:0100243)1.85634156
158Uterine leiomyosarcoma (HP:0002891)1.85634156
159Volvulus (HP:0002580)1.85242599
160Action tremor (HP:0002345)1.84381698
161Abdominal situs inversus (HP:0003363)1.83922692
162Abnormality of abdominal situs (HP:0011620)1.83922692
163Cystic liver disease (HP:0006706)1.83302444
164Cafe-au-lait spot (HP:0000957)1.82114106
165Tubulointerstitial abnormality (HP:0001969)1.82085926
166Dyskinesia (HP:0100660)1.81774146
167Overgrowth (HP:0001548)1.81745565
168Hypoplasia of the brainstem (HP:0002365)1.80856791
169Aplasia/Hypoplasia of the brainstem (HP:0007362)1.80856791
170Aplasia involving bones of the upper limbs (HP:0009823)1.80840522
171Aplasia of the phalanges of the hand (HP:0009802)1.80840522
172Aplasia involving bones of the extremities (HP:0009825)1.80840522
173Absent septum pellucidum (HP:0001331)1.79024143
174Poor coordination (HP:0002370)1.78034003

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK6.23922123
2TTK4.67212058
3MAP3K64.26879800
4TAOK34.07590274
5EEF2K3.98711318
6MAP4K23.81048586
7BRAF3.76904800
8PLK43.52026291
9CASK3.51976267
10MET3.50043941
11MUSK3.33494612
12STK103.11860847
13KSR22.76660281
14MAP3K92.70403237
15FGFR12.68122186
16ERBB42.61552788
17TNIK2.52362493
18MOS2.49444570
19MAPKAPK32.43340669
20LATS22.26525987
21MAP3K132.17937828
22CHEK22.04962935
23CDC72.01143071
24PRKD31.96030367
25LATS11.94071115
26PRKCZ1.90303158
27ARAF1.85015914
28TAOK11.82655808
29FGR1.82561009
30MAPKAPK51.77221081
31MELK1.75570233
32BMPR21.70796075
33MAP3K101.64377420
34NEK21.62089596
35PLK11.59140660
36RAF11.59095059
37INSRR1.56961155
38PTK2B1.52011546
39STK38L1.45577880
40TSSK61.45516239
41WEE11.45019735
42PASK1.44127208
43CAMK1G1.41727779
44MAP3K81.41313818
45STK31.31123087
46PDK31.30347761
47PDK41.30347761
48CDK81.28065954
49MINK11.26968570
50PAK61.25986476
51ZAK1.23392279
52MAPK131.18200987
53PRKCI1.17352684
54AURKA1.07064426
55BCR1.07021603
56MAP3K41.06706904
57CDK91.05506681
58TRPM71.01637523
59KSR10.98500132
60BMPR1B0.95094948
61TGFBR10.95024104
62TLK10.94926143
63NEK60.90440867
64CLK10.90250334
65AURKB0.86707696
66RPS6KB20.84206041
67VRK10.84134495
68STK160.82213636
69EIF2AK10.81584841
70PINK10.80693689
71MAP2K70.80446838
72BMX0.79145399
73DYRK1A0.77647604
74PRKAA20.76549927
75PRKAA10.76309061
76PIM10.74312313
77BUB10.74273254
78SGK10.73385725
79BRD40.72738758
80MARK30.72589459
81ACVR1B0.71790536
82PRKD20.69669819
83RET0.69132210
84WNK30.69062781
85MKNK20.66351386
86IRAK10.65703214
87DYRK20.64077646
88CSNK1G10.62829956
89CSF1R0.62429813
90TYRO30.60228137
91PDGFRB0.59318500
92NTRK20.58865546
93FRK0.58628476
94GRK10.58465391
95LRRK20.57794975
96PRKCG0.55886747
97PDK20.55779512
98CHEK10.54911788
99OXSR10.54201403
100PRKCE0.52754800
101CAMK2G0.52056866
102ATM0.49737575
103STK240.49409737
104PLK30.48885616
105MAPK150.48199923
106EPHA30.45685566
107EPHB10.45535311
108STK390.45048374
109MAP2K40.44981310
110PRKACB0.44263482
111MARK20.44024157
112PLK20.43951921
113STK40.43480226
114PTK20.42701943
115CSNK1G30.40724208
116CSNK1G20.40079968
117MAP3K50.39870817
118STK380.39541259
119RPS6KA50.39089068
120ADRBK10.38905510
121MAPK110.36949875
122EGFR0.36842633
123NLK0.36479611
124GSK3B0.36264555
125CDK10.35995594
126STK110.34750860
127NEK90.32444892
128CDK40.31971793
129CDK30.30926158
130DMPK0.30109474
131BRSK10.29906979
132CSNK1D0.29079671
133ABL20.28898391
134BRSK20.28415977
135NEK10.27664480
136CDK20.25648730
137MAP3K10.24303225
138ABL10.22264345
139PAK10.22091682
140CSNK1A1L0.21918068
141EPHA40.21428211
142CDK70.19612886
143CAMK2A0.19593386
144ROCK10.16092544
145AKT10.14396698
146ATR0.14365735
147MTOR0.13919348
148SGK20.12626979
149RPS6KA40.12275260
150SGK4940.11156277
151SGK2230.11156277
152MAPK10.10784223
153CSNK1E0.10384095
154MAP2K10.09661816

Predicted pathways (KEGG)

RankGene SetZ-score
1Ovarian steroidogenesis_Homo sapiens_hsa049134.73852308
2Vitamin B6 metabolism_Homo sapiens_hsa007504.15662701
3Cell cycle_Homo sapiens_hsa041104.10889336
4Nicotine addiction_Homo sapiens_hsa050333.92681752
5RNA degradation_Homo sapiens_hsa030183.51243676
6Basal transcription factors_Homo sapiens_hsa030223.18749566
7Morphine addiction_Homo sapiens_hsa050322.98325820
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.75219755
9Linoleic acid metabolism_Homo sapiens_hsa005912.65087089
10Oocyte meiosis_Homo sapiens_hsa041142.62268792
11Homologous recombination_Homo sapiens_hsa034402.55940352
12Fanconi anemia pathway_Homo sapiens_hsa034602.54406351
13Circadian rhythm_Homo sapiens_hsa047102.52655036
14Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.44648441
15Ether lipid metabolism_Homo sapiens_hsa005652.29311543
16Spliceosome_Homo sapiens_hsa030402.28055120
17Dorso-ventral axis formation_Homo sapiens_hsa043202.17053157
18Cysteine and methionine metabolism_Homo sapiens_hsa002702.03100079
19Non-homologous end-joining_Homo sapiens_hsa034502.00343123
20Pancreatic cancer_Homo sapiens_hsa052121.93300407
21p53 signaling pathway_Homo sapiens_hsa041151.90657105
22RNA transport_Homo sapiens_hsa030131.82139566
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.80646214
24Caffeine metabolism_Homo sapiens_hsa002321.76465658
25Base excision repair_Homo sapiens_hsa034101.65415504
26Butanoate metabolism_Homo sapiens_hsa006501.62804065
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.60958119
28MicroRNAs in cancer_Homo sapiens_hsa052061.54245728
29GnRH signaling pathway_Homo sapiens_hsa049121.47041941
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.43148932
31GABAergic synapse_Homo sapiens_hsa047271.43098882
32Mismatch repair_Homo sapiens_hsa034301.28405480
33TGF-beta signaling pathway_Homo sapiens_hsa043501.27713965
34Glycerophospholipid metabolism_Homo sapiens_hsa005641.26347658
35DNA replication_Homo sapiens_hsa030301.23861452
36Cyanoamino acid metabolism_Homo sapiens_hsa004601.23395847
37Choline metabolism in cancer_Homo sapiens_hsa052311.22591571
38Olfactory transduction_Homo sapiens_hsa047401.17985975
39Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.17755682
40Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.17143824
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.15222594
42Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.14764173
43VEGF signaling pathway_Homo sapiens_hsa043701.12041992
44RNA polymerase_Homo sapiens_hsa030201.09633786
45Colorectal cancer_Homo sapiens_hsa052101.08823884
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.06446347
47Prolactin signaling pathway_Homo sapiens_hsa049171.03082329
48Pyruvate metabolism_Homo sapiens_hsa006201.00613881
49Nucleotide excision repair_Homo sapiens_hsa034200.99090295
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.97765856
51mTOR signaling pathway_Homo sapiens_hsa041500.94243093
52mRNA surveillance pathway_Homo sapiens_hsa030150.93521682
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90780029
54Protein export_Homo sapiens_hsa030600.89400891
55Basal cell carcinoma_Homo sapiens_hsa052170.89049484
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83282523
57Renal cell carcinoma_Homo sapiens_hsa052110.81346937
58Fatty acid elongation_Homo sapiens_hsa000620.80454584
59Inositol phosphate metabolism_Homo sapiens_hsa005620.78461529
60Histidine metabolism_Homo sapiens_hsa003400.78061223
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.76851334
62Long-term depression_Homo sapiens_hsa047300.75203043
63Taste transduction_Homo sapiens_hsa047420.74040422
64FoxO signaling pathway_Homo sapiens_hsa040680.73516091
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.72623297
66beta-Alanine metabolism_Homo sapiens_hsa004100.71644735
67Purine metabolism_Homo sapiens_hsa002300.70822728
68Collecting duct acid secretion_Homo sapiens_hsa049660.70774605
69Cholinergic synapse_Homo sapiens_hsa047250.70720646
70Dopaminergic synapse_Homo sapiens_hsa047280.70392533
71Hippo signaling pathway_Homo sapiens_hsa043900.67356639
72Phototransduction_Homo sapiens_hsa047440.67141715
73Circadian entrainment_Homo sapiens_hsa047130.66692267
74Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64249232
75Adherens junction_Homo sapiens_hsa045200.62290987
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.60962633
77Amphetamine addiction_Homo sapiens_hsa050310.58745761
78Ras signaling pathway_Homo sapiens_hsa040140.58320123
79Arachidonic acid metabolism_Homo sapiens_hsa005900.57784189
80Cocaine addiction_Homo sapiens_hsa050300.54627107
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53798336
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52436564
83Wnt signaling pathway_Homo sapiens_hsa043100.52212882
84Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.52192939
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51782204
86Estrogen signaling pathway_Homo sapiens_hsa049150.51454729
87One carbon pool by folate_Homo sapiens_hsa006700.51378675
88Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50981861
89Steroid biosynthesis_Homo sapiens_hsa001000.50707696
90Arginine biosynthesis_Homo sapiens_hsa002200.50041182
91Endometrial cancer_Homo sapiens_hsa052130.49398959
92Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.48078528
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47363269
94Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47099984
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46371963
96Notch signaling pathway_Homo sapiens_hsa043300.44847313
97Other glycan degradation_Homo sapiens_hsa005110.44762480
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43364986
99HTLV-I infection_Homo sapiens_hsa051660.43030743
100Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42958254
101Huntingtons disease_Homo sapiens_hsa050160.41280031
102Pyrimidine metabolism_Homo sapiens_hsa002400.41194483
103Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.40315286
104Regulation of autophagy_Homo sapiens_hsa041400.38807252
105Folate biosynthesis_Homo sapiens_hsa007900.36487002
106Small cell lung cancer_Homo sapiens_hsa052220.36472649
107Steroid hormone biosynthesis_Homo sapiens_hsa001400.36385441
108Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35500919
109Non-small cell lung cancer_Homo sapiens_hsa052230.34610477
110Complement and coagulation cascades_Homo sapiens_hsa046100.34494294
111Glycerolipid metabolism_Homo sapiens_hsa005610.34094106
112Alcoholism_Homo sapiens_hsa050340.33861220
113ABC transporters_Homo sapiens_hsa020100.33586269
114Chronic myeloid leukemia_Homo sapiens_hsa052200.33350202
115Glutamatergic synapse_Homo sapiens_hsa047240.32976026
116Thyroid cancer_Homo sapiens_hsa052160.32957763
117Synaptic vesicle cycle_Homo sapiens_hsa047210.31759104
118Arginine and proline metabolism_Homo sapiens_hsa003300.30048083
119Hepatitis B_Homo sapiens_hsa051610.30038672
120Propanoate metabolism_Homo sapiens_hsa006400.28945156
121Bladder cancer_Homo sapiens_hsa052190.27448431
122Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.26854553
123Lysine degradation_Homo sapiens_hsa003100.26620316
124Glucagon signaling pathway_Homo sapiens_hsa049220.26373854
125Transcriptional misregulation in cancer_Homo sapiens_hsa052020.23757209
126Serotonergic synapse_Homo sapiens_hsa047260.23375222
127Hedgehog signaling pathway_Homo sapiens_hsa043400.23180122
128Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.22731461
129MAPK signaling pathway_Homo sapiens_hsa040100.21613486
130ErbB signaling pathway_Homo sapiens_hsa040120.21484767
131Glioma_Homo sapiens_hsa052140.20811150
132Sphingolipid signaling pathway_Homo sapiens_hsa040710.19301601
133Gap junction_Homo sapiens_hsa045400.18956097
134Vascular smooth muscle contraction_Homo sapiens_hsa042700.18300270
135AMPK signaling pathway_Homo sapiens_hsa041520.18172397
136cAMP signaling pathway_Homo sapiens_hsa040240.17954565
137Prostate cancer_Homo sapiens_hsa052150.16819058
138Oxytocin signaling pathway_Homo sapiens_hsa049210.16758316
139Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.16709922

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