NLRC5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the caspase recruitment domain-containing NLR family. This gene plays a role in cytokine response and antiviral immunity through its inhibition of NF-kappa-B activation and negative regulation of type I interferon signaling pathways. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)7.77913743
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)7.77913743
3antigen processing and presentation of endogenous antigen (GO:0019883)7.22148886
4positive regulation of gamma-delta T cell activation (GO:0046645)6.63735795
5NIK/NF-kappaB signaling (GO:0038061)5.72417790
6negative thymic T cell selection (GO:0045060)5.58441091
7negative T cell selection (GO:0043383)5.49847935
8negative regulation of cell killing (GO:0031342)5.15002735
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.15002735
10regulation of gamma-delta T cell differentiation (GO:0045586)5.00019893
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.95494444
12T cell migration (GO:0072678)4.90674595
13regulation of gamma-delta T cell activation (GO:0046643)4.81450213
14positive thymic T cell selection (GO:0045059)4.73863606
15regulation of interleukin-12 biosynthetic process (GO:0045075)4.63449619
16thymic T cell selection (GO:0045061)4.57446254
17response to type I interferon (GO:0034340)4.50200204
18type I interferon signaling pathway (GO:0060337)4.44466680
19cellular response to type I interferon (GO:0071357)4.44466680
20modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.37845133
21positive regulation by organism of defense response of other organism involved in symbiotic interact4.37845133
22modulation by symbiont of host immune response (GO:0052553)4.37845133
23positive regulation by symbiont of host defense response (GO:0052509)4.37845133
24modulation by symbiont of host defense response (GO:0052031)4.37845133
25modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.37845133
26positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.36529677
27response to interleukin-15 (GO:0070672)4.36199600
28positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.34741724
29detection of other organism (GO:0098543)4.34201219
30detection of bacterium (GO:0016045)4.32152434
31T cell selection (GO:0045058)4.31249551
32regulation of T cell tolerance induction (GO:0002664)4.20101749
33regulation of isotype switching to IgG isotypes (GO:0048302)4.14935322
34positive regulation of humoral immune response (GO:0002922)4.06895226
35negative regulation of lymphocyte mediated immunity (GO:0002707)4.01986344
36interferon-gamma production (GO:0032609)4.01024270
37regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.00245374
38cellular response to interleukin-15 (GO:0071350)3.98140972
39positive T cell selection (GO:0043368)3.97992738
40regulation of alpha-beta T cell proliferation (GO:0046640)3.96968471
41regulation of B cell receptor signaling pathway (GO:0050855)3.94415256
42interferon-gamma-mediated signaling pathway (GO:0060333)3.86351331
43macrophage activation involved in immune response (GO:0002281)3.82954071
44activated T cell proliferation (GO:0050798)3.80735447
45negative regulation of interleukin-12 production (GO:0032695)3.72351163
46regulation of RIG-I signaling pathway (GO:0039535)3.65183527
47myeloid dendritic cell activation (GO:0001773)3.63900200
48antigen processing and presentation via MHC class Ib (GO:0002475)3.61533883
49cellular extravasation (GO:0045123)3.61206335
50JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.61142484
51negative regulation of leukocyte mediated immunity (GO:0002704)3.59023176
52positive regulation of interleukin-2 production (GO:0032743)3.58448708
53myeloid dendritic cell differentiation (GO:0043011)3.57764465
54neutrophil activation involved in immune response (GO:0002283)3.56387363
55positive regulation of interferon-alpha production (GO:0032727)3.52601613
56regulation of B cell differentiation (GO:0045577)3.47354291
57positive regulation of natural killer cell differentiation (GO:0032825)3.45476446
58detection of external biotic stimulus (GO:0098581)3.45418896
59positive regulation of B cell differentiation (GO:0045579)3.44029923
60regulation of regulatory T cell differentiation (GO:0045589)3.42898598
61response to peptidoglycan (GO:0032494)3.42760565
62positive regulation of antigen processing and presentation (GO:0002579)3.40887510
63* regulation of type I interferon-mediated signaling pathway (GO:0060338)3.39680031
64leukocyte aggregation (GO:0070486)3.38797469
65regulation of interferon-alpha production (GO:0032647)3.35552275
66negative regulation of erythrocyte differentiation (GO:0045647)3.34767695
67positive regulation of isotype switching (GO:0045830)3.34382266
68T cell receptor signaling pathway (GO:0050852)3.33038305
69positive regulation of granulocyte differentiation (GO:0030854)3.29120754
70tolerance induction (GO:0002507)3.28881094
71regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.27317174
72positive regulation of alpha-beta T cell proliferation (GO:0046641)3.26813733
73T cell costimulation (GO:0031295)3.26308801
74cellular response to interferon-beta (GO:0035458)3.25900614
75lymphocyte migration (GO:0072676)3.24327092
76regulation of tolerance induction (GO:0002643)3.22716913
77natural killer cell mediated immunity (GO:0002228)3.21577980
78natural killer cell mediated cytotoxicity (GO:0042267)3.21577980
79response to muramyl dipeptide (GO:0032495)3.21314034
80regulation of interleukin-2 biosynthetic process (GO:0045076)3.20297937
81lymphocyte costimulation (GO:0031294)3.20110635
82germinal center formation (GO:0002467)3.17075640
83antigen receptor-mediated signaling pathway (GO:0050851)3.16409618
84B cell receptor signaling pathway (GO:0050853)3.15629394
85mature B cell differentiation (GO:0002335)3.15238002
86regulation of T cell mediated cytotoxicity (GO:0001914)3.15185712
87negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.13849707
88positive regulation of B cell mediated immunity (GO:0002714)3.13320345
89positive regulation of immunoglobulin mediated immune response (GO:0002891)3.13320345
90T-helper cell differentiation (GO:0042093)3.10068931
91CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.10068931
92regulation of hypersensitivity (GO:0002883)3.09266520
93positive regulation of T cell cytokine production (GO:0002726)3.07576709
94alpha-beta T cell activation (GO:0046631)3.07236841
95response to host immune response (GO:0052572)3.06354158
96response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.06354158
97negative regulation of T cell mediated immunity (GO:0002710)3.06247212
98positive regulation of tolerance induction (GO:0002645)3.06020688
99regulation of T cell receptor signaling pathway (GO:0050856)3.05726138
100natural killer cell activation (GO:0030101)3.05252127
101regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.04663580
102myeloid cell activation involved in immune response (GO:0002275)3.03502772
103detection of biotic stimulus (GO:0009595)3.00941024
104* positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.00268474
105immunoglobulin mediated immune response (GO:0016064)2.97208086
106T cell homeostasis (GO:0043029)2.96810688
107regulation of antigen processing and presentation (GO:0002577)2.96731275
108negative regulation of T-helper cell differentiation (GO:0045623)2.95169239
109negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.95169239
110response to host defenses (GO:0052200)2.95038396
111response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.95038396
112response to host (GO:0075136)2.95038396
113* regulation of response to interferon-gamma (GO:0060330)2.94274728
114regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.93323663
115respiratory burst (GO:0045730)2.93304960
116positive regulation of T cell mediated cytotoxicity (GO:0001916)2.93199042
117negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.91591124
118regulation of necroptotic process (GO:0060544)2.91433358
119regulation of dendritic cell antigen processing and presentation (GO:0002604)2.91065343
120T cell proliferation (GO:0042098)2.91024838
121regulation of natural killer cell mediated immunity (GO:0002715)2.90960019
122regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.90960019
123regulation of interferon-beta biosynthetic process (GO:0045357)2.90638888
124cellular response to interferon-gamma (GO:0071346)2.90602119
125leukocyte cell-cell adhesion (GO:0007159)2.90073045
126neutrophil activation (GO:0042119)2.88773747
127defense response to protozoan (GO:0042832)2.88741260
128detection of molecule of bacterial origin (GO:0032490)2.88507203
129positive regulation of DNA recombination (GO:0045911)2.87393925
130positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.86875741
131natural killer cell differentiation (GO:0001779)2.85338013
132alpha-beta T cell activation involved in immune response (GO:0002287)2.82997629
133T cell differentiation involved in immune response (GO:0002292)2.82997629
134alpha-beta T cell differentiation involved in immune response (GO:0002293)2.82997629
135response to protozoan (GO:0001562)2.82569880
136positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.81699209
137microglial cell activation (GO:0001774)2.81164890
138B cell homeostasis (GO:0001782)2.80141340
139B cell mediated immunity (GO:0019724)2.77997091
140lymphocyte homeostasis (GO:0002260)2.74479716
141granulocyte activation (GO:0036230)2.72085667

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.51597422
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.24351758
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.85198301
4* IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.71471729
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.65061247
6IRF8_21731497_ChIP-ChIP_J774_Mouse4.37771211
7STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.52748109
8STAT4_19710469_ChIP-ChIP_TH1__Mouse3.16069988
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.13985179
10IRF8_27001747_Chip-Seq_BMDM_Mouse3.06638519
11RUNX_20019798_ChIP-Seq_JUKART_Human2.93164460
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.83809169
13FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.81761381
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.78776340
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.75102254
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.73971611
17MYB_26560356_Chip-Seq_TH2_Human2.69134886
18NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.68774010
19MAF_26560356_Chip-Seq_TH1_Human2.60486564
20MYC_22102868_ChIP-Seq_BL_Human2.59635301
21MYB_26560356_Chip-Seq_TH1_Human2.43813595
22MYB_21317192_ChIP-Seq_ERMYB_Mouse2.36992615
23RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.34449707
24VDR_21846776_ChIP-Seq_THP-1_Human2.24520006
25BP1_19119308_ChIP-ChIP_Hs578T_Human2.11677511
26UTX_26944678_Chip-Seq_JUKART_Human2.03788400
27SCL_19346495_ChIP-Seq_HPC-7_Human1.96768488
28E2F7_22180533_ChIP-Seq_HELA_Human1.91249274
29SPI1_23547873_ChIP-Seq_NB4_Human1.89120817
30TCF7_22412390_ChIP-Seq_EML_Mouse1.88375229
31STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.87615629
32BRD4_27068464_Chip-Seq_AML-cells_Mouse1.85345015
33RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.85120921
34VDR_24763502_ChIP-Seq_THP-1_Human1.81679434
35GATA1_22025678_ChIP-Seq_K562_Human1.81268834
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.79661034
37ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.77584601
38E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.77098509
39GATA3_27048872_Chip-Seq_THYMUS_Human1.76495280
40TP63_17297297_ChIP-ChIP_HaCaT_Human1.74694732
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.70954605
42KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.70464775
43* MAF_26560356_Chip-Seq_TH2_Human1.67803931
44NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.64854807
45Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.53205135
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.52408497
47PU_27001747_Chip-Seq_BMDM_Mouse1.47079599
48KDM2B_26808549_Chip-Seq_DND41_Human1.46863075
49SPI1_23127762_ChIP-Seq_K562_Human1.46174337
50KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.43531618
51STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.43337962
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.40331674
53* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.39438273
54KDM2B_26808549_Chip-Seq_SUP-B15_Human1.33415784
55GATA2_22383799_ChIP-Seq_G1ME_Mouse1.31151711
56PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29802841
57GATA3_26560356_Chip-Seq_TH2_Human1.28001965
58FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.27457230
59MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.26498417
60* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23266140
61ELK3_25401928_ChIP-Seq_HUVEC_Human1.23176076
62LXR_22292898_ChIP-Seq_THP-1_Human1.20535855
63CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19361290
64CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18427931
65CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.18035453
66THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.11370612
67VDR_24787735_ChIP-Seq_THP-1_Human1.11052736
68TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.10536690
69STAT6_21828071_ChIP-Seq_BEAS2B_Human1.10312815
70LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.07241259
71NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.06831541
72SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01870978
73VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.00946363
74SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.98674852
75TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.98264939
76PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96798527
77GATA1_22383799_ChIP-Seq_G1ME_Mouse0.96394326
78GATA1_19941827_ChIP-Seq_MEL_Mouse0.93702158
79CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92879521
80RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.92730464
81BCL6_27268052_Chip-Seq_Bcells_Human0.92439041
82SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.91701353
83BCOR_27268052_Chip-Seq_Bcells_Human0.90631134
84KDM2B_26808549_Chip-Seq_JURKAT_Human0.88716515
85PPARA_22158963_ChIP-Seq_LIVER_Mouse0.88510946
86CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87313198
87CTCF_27219007_Chip-Seq_ERYTHROID_Human0.87301981
88GATA2_21666600_ChIP-Seq_HMVEC_Human0.86910695
89GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.85711546
90SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85051322
91PU.1_20513432_ChIP-Seq_Bcells_Mouse0.84490672
92RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83456070
93FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.82572236
94FOXO3_23340844_ChIP-Seq_DLD1_Human0.82069072
95TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81537004
96LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.80989112
97IKZF1_21737484_ChIP-ChIP_HCT116_Human0.80573947
98PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80390500
99BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.78857403
100PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.77770431
101KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.77393800
102GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.76378413
103NCOR1_26117541_ChIP-Seq_K562_Human0.76196968
104ELF1_17652178_ChIP-ChIP_JURKAT_Human0.76020982
105CIITA_25753668_ChIP-Seq_RAJI_Human0.74395480
106* EGR1_23403033_ChIP-Seq_LIVER_Mouse0.73815455
107ERG_20887958_ChIP-Seq_HPC-7_Mouse0.73062603
108TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.72718122
109GATA2_19941826_ChIP-Seq_K562_Human0.72393275
110GATA1_19941826_ChIP-Seq_K562_Human0.69626495
111EGR1_19032775_ChIP-ChIP_M12_Human0.66368082
112GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.65749092
113SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.64995190

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.35933316
2MP0000685_abnormal_immune_system3.77570677
3MP0005671_abnormal_response_to3.54519796
4MP0003763_abnormal_thymus_physiology3.33745909
5MP0005387_immune_system_phenotype3.26231439
6MP0001790_abnormal_immune_system3.26231439
7MP0001800_abnormal_humoral_immune3.21243644
8MP0002166_altered_tumor_susceptibility3.14697686
9MP0009785_altered_susceptibility_to3.02048972
10MP0003436_decreased_susceptibility_to2.98340148
11MP0005000_abnormal_immune_tolerance2.89915569
12MP0002723_abnormal_immune_serum2.73976660
13MP0002452_abnormal_antigen_presenting2.71085948
14MP0002006_tumorigenesis2.63682780
15MP0005025_abnormal_response_to2.63342928
16MP0002420_abnormal_adaptive_immunity2.57182094
17MP0001819_abnormal_immune_cell2.56804344
18MP0004510_myositis2.52536962
19MP0002148_abnormal_hypersensitivity_rea2.42262352
20MP0004947_skin_inflammation2.36509394
21MP0002398_abnormal_bone_marrow2.31393258
22MP0006082_CNS_inflammation2.28055590
23MP0002419_abnormal_innate_immunity2.26407181
24MP0001873_stomach_inflammation2.26362718
25MP0002138_abnormal_hepatobiliary_system2.21569371
26MP0000716_abnormal_immune_system2.14319932
27MP0002254_reproductive_system_inflammat2.08718068
28MP0003303_peritoneal_inflammation2.04140859
29MP0002405_respiratory_system_inflammati2.01812037
30MP0003724_increased_susceptibility_to1.97179488
31MP0002396_abnormal_hematopoietic_system1.96914162
32MP0010155_abnormal_intestine_physiology1.93445712
33MP0003300_gastrointestinal_ulcer1.89707314
34MP0009333_abnormal_splenocyte_physiolog1.87506505
35MP0000689_abnormal_spleen_morphology1.85364292
36MP0005464_abnormal_platelet_physiology1.82529564
37MP0002722_abnormal_immune_system1.81086703
38MP0001853_heart_inflammation1.77117157
39MP0002429_abnormal_blood_cell1.74060256
40MP0001845_abnormal_inflammatory_respons1.70369777
41MP0000703_abnormal_thymus_morphology1.68484253
42MP0008260_abnormal_autophagy1.64598509
43MP0002009_preneoplasia1.58494900
44MP0000569_abnormal_digit_pigmentation1.54445111
45MP0005310_abnormal_salivary_gland1.53078424
46MP0004808_abnormal_hematopoietic_stem1.48884716
47MP0005451_abnormal_body_composition1.44085259
48MP0008469_abnormal_protein_level1.42778284
49MP0003448_altered_tumor_morphology1.39030591
50MP0003866_abnormal_defecation1.38196658
51MP0001533_abnormal_skeleton_physiology1.34491151
52MP0005397_hematopoietic_system_phenotyp1.33739998
53MP0001545_abnormal_hematopoietic_system1.33739998
54MP0003828_pulmonary_edema1.27208128
55MP0009278_abnormal_bone_marrow1.23469572
56MP0000858_altered_metastatic_potential1.21609205
57MP0009764_decreased_sensitivity_to1.15791115
58MP0002933_joint_inflammation1.15258253
59MP0002132_abnormal_respiratory_system1.15251366
60MP0004381_abnormal_hair_follicle1.12629078
61MP0003453_abnormal_keratinocyte_physiol1.12504397
62MP0010352_gastrointestinal_tract_polyps1.09877474
63MP0004883_abnormal_blood_vessel1.09838083
64MP0003191_abnormal_cellular_cholesterol1.09171711
65MP0005174_abnormal_tail_pigmentation1.06662269
66MP0000465_gastrointestinal_hemorrhage1.01780687
67MP0003172_abnormal_lysosome_physiology0.96386354
68MP0002998_abnormal_bone_remodeling0.96169849
69MP0005058_abnormal_lysosome_morphology0.94542099
70MP0001348_abnormal_lacrimal_gland0.93756084
71MP0001663_abnormal_digestive_system0.92677055
72MP0009763_increased_sensitivity_to0.91956710
73MP0000604_amyloidosis0.91918933
74MP0010307_abnormal_tumor_latency0.87407384
75MP0001851_eye_inflammation0.86555669
76MP0009840_abnormal_foam_cell0.86105107
77MP0005166_decreased_susceptibility_to0.85892748
78MP0005164_abnormal_response_to0.83620012
79MP0002877_abnormal_melanocyte_morpholog0.82836361
80MP0005075_abnormal_melanosome_morpholog0.82430844
81MP0003690_abnormal_glial_cell0.82344786
82MP0002277_abnormal_respiratory_mucosa0.81130090
83MP0005076_abnormal_cell_differentiation0.80962381
84MP0002019_abnormal_tumor_incidence0.80949708
85MP0003091_abnormal_cell_migration0.79645568
86MP0000609_abnormal_liver_physiology0.79396058
87MP0003045_fibrosis0.77849515
88MP0005390_skeleton_phenotype0.76626703
89MP0000490_abnormal_crypts_of0.75723416
90MP0001216_abnormal_epidermal_layer0.73583277
91MP0008004_abnormal_stomach_pH0.72587271
92MP0003566_abnormal_cell_adhesion0.72238905
93MP0009765_abnormal_xenobiotic_induced0.69403076
94MP0003075_altered_response_to0.69294703
95MP0005023_abnormal_wound_healing0.68707804
96MP0010234_abnormal_vibrissa_follicle0.68693980
97MP0000371_diluted_coat_color0.67785518
98MP0002136_abnormal_kidney_physiology0.67736101
99MP0001986_abnormal_taste_sensitivity0.66025816
100MP0004130_abnormal_muscle_cell0.65604993
101MP0003795_abnormal_bone_structure0.63470364
102MP0003183_abnormal_peptide_metabolism0.63036240
103MP0003656_abnormal_erythrocyte_physiolo0.62837872
104MP0001191_abnormal_skin_condition0.60875183
105MP0008057_abnormal_DNA_replication0.58664463
106MP0001243_abnormal_dermal_layer0.58117568
107MP0008874_decreased_physiological_sensi0.57321059
108MP0002163_abnormal_gland_morphology0.55927467
109MP0000249_abnormal_blood_vessel0.55497717
110MP0009115_abnormal_fat_cell0.53629246
111MP0005381_digestive/alimentary_phenotyp0.52761891
112MP0001881_abnormal_mammary_gland0.52452897
113MP0000367_abnormal_coat/_hair0.51789780
114MP0003279_aneurysm0.51735080
115MP0000343_altered_response_to0.51150584
116MP0002693_abnormal_pancreas_physiology0.51094569
117MP0002796_impaired_skin_barrier0.50966157
118MP0000598_abnormal_liver_morphology0.50413285
119MP0008961_abnormal_basal_metabolism0.50053119
120MP0009931_abnormal_skin_appearance0.49859088
121MP0002332_abnormal_exercise_endurance0.49683070
122MP0000015_abnormal_ear_pigmentation0.49117320

Predicted human phenotypes

RankGene SetZ-score
1Chronic otitis media (HP:0000389)5.48605713
2Elevated erythrocyte sedimentation rate (HP:0003565)4.90076893
3Recurrent viral infections (HP:0004429)4.81961216
4Nasal polyposis (HP:0100582)4.80444963
5Abnormality of T cell number (HP:0011839)4.63651382
6Recurrent fungal infections (HP:0002841)4.61547698
7T lymphocytopenia (HP:0005403)4.55610283
8Eczematoid dermatitis (HP:0000976)4.48940204
9Recurrent bronchitis (HP:0002837)4.44360463
10Autoimmune thrombocytopenia (HP:0001973)4.25629944
11Recurrent abscess formation (HP:0002722)4.20545529
12Abnormality of the nasal mucosa (HP:0000433)4.19215461
13Myositis (HP:0100614)4.14865283
14Abnormal delayed hypersensitivity skin test (HP:0002963)4.13406558
15Recurrent bacterial skin infections (HP:0005406)4.03547190
16Recurrent cutaneous fungal infections (HP:0011370)3.93874507
17Chronic mucocutaneous candidiasis (HP:0002728)3.93874507
18Increased IgE level (HP:0003212)3.82751078
19Abnormality of the fingertips (HP:0001211)3.70249856
20Abnormality of T cells (HP:0002843)3.68617351
21Vasculitis (HP:0002633)3.63003846
22Mediastinal lymphadenopathy (HP:0100721)3.61720679
23Pustule (HP:0200039)3.54078531
24Panhypogammaglobulinemia (HP:0003139)3.48299826
25Agammaglobulinemia (HP:0004432)3.45796162
26Recurrent skin infections (HP:0001581)3.44456067
27Retrobulbar optic neuritis (HP:0100654)3.37126616
28Optic neuritis (HP:0100653)3.37126616
29Stomatitis (HP:0010280)3.36240588
30Orchitis (HP:0100796)3.33838966
31Inflammation of the large intestine (HP:0002037)3.28170101
32Colitis (HP:0002583)3.27933819
33Gastrointestinal inflammation (HP:0004386)3.17461824
34Meningitis (HP:0001287)3.11832082
35Eosinophilia (HP:0001880)3.08046948
36Chronic sinusitis (HP:0011109)3.05569579
37Autoimmune hemolytic anemia (HP:0001890)3.05233705
38Increased IgM level (HP:0003496)3.03933622
39Pulmonary infiltrates (HP:0002113)3.03731916
40IgM deficiency (HP:0002850)3.03212326
41Hypergammaglobulinemia (HP:0010702)3.02104030
42Periodontitis (HP:0000704)3.02084097
43Gastrointestinal infarctions (HP:0005244)2.99613648
44Thrombocytosis (HP:0001894)2.99464343
45Gingival bleeding (HP:0000225)2.98562317
46Arterial thrombosis (HP:0004420)2.96133876
47Leukocytosis (HP:0001974)2.95761071
48Abnormality of T cell physiology (HP:0011840)2.95548110
49Spontaneous hematomas (HP:0007420)2.89641046
50Joint swelling (HP:0001386)2.87880376
51Granulocytopenia (HP:0001913)2.80688711
52Abnormality of eosinophils (HP:0001879)2.80610777
53IgG deficiency (HP:0004315)2.79772268
54Lymphopenia (HP:0001888)2.78454325
55Abnormality of cells of the lymphoid lineage (HP:0012140)2.77150632
56Severe combined immunodeficiency (HP:0004430)2.75161312
57Abnormality of macrophages (HP:0004311)2.75104422
58Recurrent gram-negative bacterial infections (HP:0005420)2.73770667
59Hemoptysis (HP:0002105)2.73718922
60Chronic diarrhea (HP:0002028)2.72005530
61Cellulitis (HP:0100658)2.70814231
62Combined immunodeficiency (HP:0005387)2.69191038
63Myocardial infarction (HP:0001658)2.65440598
64Urticaria (HP:0001025)2.63902795
65Encephalitis (HP:0002383)2.60685477
66Emphysema (HP:0002097)2.58673786
67Verrucae (HP:0200043)2.57974536
68Papilloma (HP:0012740)2.57974536
69IgA deficiency (HP:0002720)2.52645468
70Epistaxis (HP:0000421)2.51703349
71Papilledema (HP:0001085)2.51433118
72Gingivitis (HP:0000230)2.50424094
73Interstitial pulmonary disease (HP:0006530)2.45989810
74Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.45097811
75Bronchitis (HP:0012387)2.43972977
76Chronic obstructive pulmonary disease (HP:0006510)2.42807830
77Obstructive lung disease (HP:0006536)2.42807830
78Thyroiditis (HP:0100646)2.42748269
79Hypochromic anemia (HP:0001931)2.40930552
80Chest pain (HP:0100749)2.40609703
81Keratoconjunctivitis sicca (HP:0001097)2.39615240
82Gastrointestinal stroma tumor (HP:0100723)2.37067469
83Fatigue (HP:0012378)2.33371300
84Hematochezia (HP:0002573)2.32319459
85Skin ulcer (HP:0200042)2.30506244
86Keratoconjunctivitis (HP:0001096)2.30043439
87Viral hepatitis (HP:0006562)2.29050425
88Anorexia (HP:0002039)2.27170184
89B lymphocytopenia (HP:0010976)2.24867323
90Abnormality of B cell number (HP:0010975)2.24867323
91Prolonged bleeding time (HP:0003010)2.24613768
92Slow saccadic eye movements (HP:0000514)2.24205534
93Abnormality of the pleura (HP:0002103)2.17836749
94Recurrent sinusitis (HP:0011108)2.16989157
95Sepsis (HP:0100806)2.14962745
96Pulmonary embolism (HP:0002204)2.13422157
97Abnormality of the prostate (HP:0008775)2.11826076
98Basal ganglia calcification (HP:0002135)2.08093277
99Restrictive lung disease (HP:0002091)2.05681438
100Osteomyelitis (HP:0002754)2.04548823
101Thick nail (HP:0001805)2.04104888
102Lymphoma (HP:0002665)2.02928154
103Osteolytic defects of the hand bones (HP:0009699)2.01944759
104Osteolytic defects of the phalanges of the hand (HP:0009771)2.01944759
105Hypochromic microcytic anemia (HP:0004840)2.01081008
106Gangrene (HP:0100758)2.00202357
107Abnormal platelet volume (HP:0011876)1.98986723
108Cheilitis (HP:0100825)1.98044674
109Episodic fever (HP:0001954)1.97754682
110Petechiae (HP:0000967)1.94093200
111Glomerulopathy (HP:0100820)1.93482990
112Peritonitis (HP:0002586)1.91982515
113Amaurosis fugax (HP:0100576)1.91869476
114Malnutrition (HP:0004395)1.90955794
115Arthralgia (HP:0002829)1.88971756
116Acute hepatic failure (HP:0006554)1.88457832
117Microcytic anemia (HP:0001935)1.87197687
118Premature loss of primary teeth (HP:0006323)1.86716281
119Abnormality of the peritoneum (HP:0002585)1.85804181

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.35025430
2MAP3K144.02425354
3TYK24.02097891
4JAK33.68856036
5FGFR43.32788332
6IKBKE3.26749214
7PRPF4B3.23286045
8TXK3.13770312
9JAK12.93382165
10MAP3K132.87330641
11TBK12.67928448
12KIT2.24247893
13FGFR32.21164591
14IKBKB2.18004707
15ITK2.12966080
16ZAP701.98899478
17MAP3K101.83731654
18IRAK41.79821473
19STK101.79211697
20CHUK1.64473224
21GRK61.63646778
22BLK1.61610121
23LCK1.56069948
24SYK1.49468691
25EPHB11.45515146
26BTK1.41898758
27CSK1.40713352
28IRAK31.35877475
29HCK1.34268549
30TEC1.33722143
31NLK1.31466476
32CSF1R1.29378742
33SIK21.28922031
34ERN11.28561386
35EEF2K1.27582039
36EPHA31.26731542
37CDC42BPA1.21486117
38FLT31.19306867
39RIPK41.18035882
40JAK21.16414928
41TAOK11.13557269
42PIM11.09291725
43CDK121.05590480
44LRRK21.03490116
45MARK21.02007955
46MAP3K10.96822645
47PRKCQ0.93678598
48RPS6KA40.93064227
49SMG10.92984010
50PKN20.91596131
51MARK30.91146837
52MAP3K110.87294214
53TAOK30.87198943
54MST40.86923029
55MAPK70.84374183
56BMPR20.83288439
57TRIB30.81657794
58TGFBR20.80957176
59TTN0.79498196
60MAPK120.77377709
61PRKD20.77169285
62NEK90.76065483
63LYN0.75359839
64PTK60.74143241
65CAMKK10.71251065
66FES0.70768722
67NME20.70572641
68IRAK10.70407292
69MAP3K70.70070701
70CAMKK20.69980283
71YES10.69460472
72MAP2K30.66561370
73TAOK20.65244336
74STK40.64399148
75SIK10.63320673
76SIK30.62036588
77KSR20.61120987
78PRKAA20.57189448
79MAPK110.57003415
80PDPK10.56773426
81PASK0.55926703
82PRKCH0.54607904
83CDK40.53082200
84PIM20.52935792
85FYN0.52560591
86TRPM70.51193258
87CLK10.50854247
88PIK3CG0.50646183
89HIPK20.49351120
90MATK0.48732390
91KDR0.47269901
92MAP3K60.46965561
93CDK60.46307203
94TGFBR10.44655652
95PKN10.43388332
96GRK70.42600620
97RPS6KA50.42381590
98PDGFRB0.41642078
99STK380.40975777
100RPS6KC10.40520747
101RPS6KL10.40520747
102EGFR0.39660864
103IRAK20.39101890
104PTK2B0.37459706
105ABL10.37427499
106MAP2K60.37125824
107TYRO30.36145694
108STK110.35852962
109PDK10.35437342
110SGK20.35377004
111MAPKAPK20.34624754
112CAMK1D0.34566198
113MAP3K30.33359051
114RIPK10.31657145
115TNK20.30164627
116BMX0.29155351
117RET0.28886690
118CDK90.26903360
119FGFR20.26051902
120RPS6KA60.26001231
121IGF1R0.25515873
122SGK30.25194062
123MAPK40.25042371
124PRKCD0.24802402
125MELK0.24510687
126ALK0.24121482
127MAPK30.23453951
128INSR0.23377231
129NEK20.23029270
130DYRK1B0.22815687
131EIF2AK20.22468443
132FGR0.22461373

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.80725595
2NF-kappa B signaling pathway_Homo sapiens_hsa040643.26402393
3Measles_Homo sapiens_hsa051622.93028035
4Allograft rejection_Homo sapiens_hsa053302.87031286
5Graft-versus-host disease_Homo sapiens_hsa053322.84970655
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.71142479
7Leishmaniasis_Homo sapiens_hsa051402.61261782
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.45382677
9T cell receptor signaling pathway_Homo sapiens_hsa046602.44389744
10RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.39626969
11Osteoclast differentiation_Homo sapiens_hsa043802.34097932
12Antigen processing and presentation_Homo sapiens_hsa046122.28710835
13B cell receptor signaling pathway_Homo sapiens_hsa046622.27202490
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.15579885
15Toll-like receptor signaling pathway_Homo sapiens_hsa046202.14128731
16Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.10194536
17NOD-like receptor signaling pathway_Homo sapiens_hsa046212.02876339
18Herpes simplex infection_Homo sapiens_hsa051681.99643179
19Jak-STAT signaling pathway_Homo sapiens_hsa046301.96646496
20Toxoplasmosis_Homo sapiens_hsa051451.88399310
21Influenza A_Homo sapiens_hsa051641.87853261
22Autoimmune thyroid disease_Homo sapiens_hsa053201.82017699
23TNF signaling pathway_Homo sapiens_hsa046681.81963736
24Staphylococcus aureus infection_Homo sapiens_hsa051501.77590798
25Hematopoietic cell lineage_Homo sapiens_hsa046401.70758992
26Viral myocarditis_Homo sapiens_hsa054161.59084008
27Apoptosis_Homo sapiens_hsa042101.57903926
28Chemokine signaling pathway_Homo sapiens_hsa040621.47599549
29Acute myeloid leukemia_Homo sapiens_hsa052211.44247452
30Hepatitis B_Homo sapiens_hsa051611.38025024
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.37150718
32Hepatitis C_Homo sapiens_hsa051601.35610618
33Type I diabetes mellitus_Homo sapiens_hsa049401.32957437
34Malaria_Homo sapiens_hsa051441.31498766
35Legionellosis_Homo sapiens_hsa051341.31422876
36Tuberculosis_Homo sapiens_hsa051521.29727159
37Pertussis_Homo sapiens_hsa051331.25880382
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.23644759
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.20115981
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.17972281
41Shigellosis_Homo sapiens_hsa051311.13065157
42Chronic myeloid leukemia_Homo sapiens_hsa052201.05840106
43Leukocyte transendothelial migration_Homo sapiens_hsa046701.05484956
44Caffeine metabolism_Homo sapiens_hsa002321.03423405
45Small cell lung cancer_Homo sapiens_hsa052221.02747350
46Asthma_Homo sapiens_hsa053101.02345661
47Prolactin signaling pathway_Homo sapiens_hsa049171.01898780
48Epstein-Barr virus infection_Homo sapiens_hsa051690.95703386
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.95199776
50Pancreatic cancer_Homo sapiens_hsa052120.94642828
51Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.91412874
52Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.90576992
53African trypanosomiasis_Homo sapiens_hsa051430.84648577
54HTLV-I infection_Homo sapiens_hsa051660.84055502
55Platelet activation_Homo sapiens_hsa046110.82020837
56Transcriptional misregulation in cancer_Homo sapiens_hsa052020.81798193
57Phagosome_Homo sapiens_hsa041450.81047660
58Viral carcinogenesis_Homo sapiens_hsa052030.78359256
59Adipocytokine signaling pathway_Homo sapiens_hsa049200.77606147
60Salmonella infection_Homo sapiens_hsa051320.73059537
61Insulin resistance_Homo sapiens_hsa049310.72520967
62Rheumatoid arthritis_Homo sapiens_hsa053230.67968245
63Endometrial cancer_Homo sapiens_hsa052130.67690901
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.65024477
65ABC transporters_Homo sapiens_hsa020100.64492612
66p53 signaling pathway_Homo sapiens_hsa041150.62567470
67VEGF signaling pathway_Homo sapiens_hsa043700.60783287
68GnRH signaling pathway_Homo sapiens_hsa049120.60699721
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58746022
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58671064
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57107567
72Non-small cell lung cancer_Homo sapiens_hsa052230.55114566
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51314524
74Notch signaling pathway_Homo sapiens_hsa043300.45223906
75HIF-1 signaling pathway_Homo sapiens_hsa040660.43840504
76Glycerophospholipid metabolism_Homo sapiens_hsa005640.42059800
77ErbB signaling pathway_Homo sapiens_hsa040120.41159763
78Glycosaminoglycan degradation_Homo sapiens_hsa005310.41120738
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40960455
80FoxO signaling pathway_Homo sapiens_hsa040680.39885457
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39544530
82MicroRNAs in cancer_Homo sapiens_hsa052060.39415232
83Lysine degradation_Homo sapiens_hsa003100.39225872
84Glioma_Homo sapiens_hsa052140.35373357
85Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.35300476
86Complement and coagulation cascades_Homo sapiens_hsa046100.32003423
87Type II diabetes mellitus_Homo sapiens_hsa049300.31918763
88mTOR signaling pathway_Homo sapiens_hsa041500.31745906
89Rap1 signaling pathway_Homo sapiens_hsa040150.31647725
90Long-term potentiation_Homo sapiens_hsa047200.30120042
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29762220
92MAPK signaling pathway_Homo sapiens_hsa040100.29345659
93Inositol phosphate metabolism_Homo sapiens_hsa005620.28795324
94Prostate cancer_Homo sapiens_hsa052150.28596677
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.28547019
96Colorectal cancer_Homo sapiens_hsa052100.28437719
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.28081266
98Amoebiasis_Homo sapiens_hsa051460.27398857
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.26864324
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.25185407
101Proteoglycans in cancer_Homo sapiens_hsa052050.24000668
102Lysosome_Homo sapiens_hsa041420.22962557
103Carbohydrate digestion and absorption_Homo sapiens_hsa049730.22739314
104Dorso-ventral axis formation_Homo sapiens_hsa043200.21595925
105Pathways in cancer_Homo sapiens_hsa052000.19588722
106Other glycan degradation_Homo sapiens_hsa005110.19536823
107Endocytosis_Homo sapiens_hsa041440.17618384
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.16468338
109Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.14101339
110Choline metabolism in cancer_Homo sapiens_hsa052310.13045961
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.12179000
112Renal cell carcinoma_Homo sapiens_hsa052110.11616406
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.10296137

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